Publication Date:
1980-07-11
Description:
When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. Evidence is presented that this reflects the lipophilic character of the derivative and the very high ratio of lipid to DNA in mitochondria. These results suggest that mitochondrial DNA may be an important cellular target of chemical carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Backer, J M -- Weinstein, I B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):297-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770466" target="_blank"〉PubMed〈/a〉
Keywords:
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
;
Animals
;
Benzopyrenes/*metabolism
;
Cell Line
;
Cell Nucleus/metabolism
;
DNA Replication/drug effects
;
DNA, Mitochondrial/*metabolism
;
Embryo, Mammalian
;
Embryo, Nonmammalian
;
L Cells (Cell Line)
;
Liposomes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
