Publication Date:
2013-07-28
Description:
Histocompatibility is the basis by which multicellular organisms of the same species distinguish self from nonself. Relatively little is known about the mechanisms underlying histocompatibility reactions in lower organisms. Botryllus schlosseri is a colonial urochordate, a sister group of vertebrates, that exhibits a genetically determined natural transplantation reaction, whereby self-recognition between colonies leads to formation of parabionts with a common vasculature, whereas rejection occurs between incompatible colonies. Using genetically defined lines, whole-transcriptome sequencing, and genomics, we identified a single gene that encodes self-nonself and determines "graft" outcomes in this organism. This gene is significantly up-regulated in colonies poised to undergo fusion and/or rejection, is highly expressed in the vasculature, and is functionally linked to histocompatibility outcomes. These findings establish a platform for advancing the science of allorecognition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810301/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810301/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Voskoboynik, Ayelet -- Newman, Aaron M -- Corey, Daniel M -- Sahoo, Debashis -- Pushkarev, Dmitry -- Neff, Norma F -- Passarelli, Benedetto -- Koh, Winston -- Ishizuka, Katherine J -- Palmeri, Karla J -- Dimov, Ivan K -- Keasar, Chen -- Fan, H Christina -- Mantalas, Gary L -- Sinha, Rahul -- Penland, Lolita -- Quake, Stephen R -- Weissman, Irving L -- 1R01AG037968/AG/NIA NIH HHS/ -- 1R56AI089968/AI/NIAID NIH HHS/ -- K12 HL087746/HL/NHLBI NIH HHS/ -- K99 CA151673/CA/NCI NIH HHS/ -- K99CA151673-01A1/CA/NCI NIH HHS/ -- R01 AG037968/AG/NIA NIH HHS/ -- R01 GM100315/GM/NIGMS NIH HHS/ -- R01GM100315/GM/NIGMS NIH HHS/ -- R56 AI089968/AI/NIAID NIH HHS/ -- T32 CA009302/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Jul 26;341(6144):384-7. doi: 10.1126/science.1238036.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. ayeletv@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23888037" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
*Genes
;
Genome
;
Genotype
;
Histocompatibility/*genetics
;
Immune Tolerance
;
Molecular Sequence Data
;
Sequence Analysis, DNA
;
Transcriptome
;
Up-Regulation
;
Urochordata/*genetics/*immunology/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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