Publication Date:
2007-10-20
Description:
A computational analysis of the nuclear genome of a red alga, Cyanidioschyzon merolae, identified 11 transfer RNA (tRNA) genes in which the 3' half of the tRNA lies upstream of the 5' half in the genome. We verified that these genes are expressed and produce mature tRNAs that are aminoacylated. Analysis of tRNA-processing intermediates for these genes indicates an unusual processing pathway in which the termini of the tRNA precursor are ligated, resulting in formation of a characteristic circular RNA intermediate that is then processed at the acceptor stem to generate the correct termini.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soma, Akiko -- Onodera, Akinori -- Sugahara, Junichi -- Kanai, Akio -- Yachie, Nozomu -- Tomita, Masaru -- Kawamura, Fujio -- Sekine, Yasuhiko -- New York, N.Y. -- Science. 2007 Oct 19;318(5849):450-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Life Science, College of Science, Rikkyo (St. Paul's) University, Toshima, Tokyo 171-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17947580" target="_blank"〉PubMed〈/a〉
Keywords:
Base Sequence
;
DNA, Algal/chemistry/genetics
;
*Genes
;
Methionine-tRNA Ligase/metabolism
;
Molecular Sequence Data
;
Nucleic Acid Conformation
;
RNA/chemistry/genetics/*metabolism
;
RNA Processing, Post-Transcriptional
;
RNA, Algal/*genetics/metabolism
;
RNA, Transfer/*genetics/metabolism
;
RNA, Transfer, Amino Acyl/metabolism
;
Rhodophyta/*genetics/metabolism
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
