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  • 1
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    DNA methylation dynamics in honey bee larvae [Genetics] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-03-28
    Description: In honey bees (Apis mellifera), the development of a larva into either a queen or worker depends on differential feeding with royal jelly and involves epigenomic modifications by DNA methyltransferases. To understand the role of DNA methylation in this process we sequenced the larval methylomes in both queens and workers. We show that the number of differentially methylated genes (DMGs) in larval head is significantly increased relative to adult brain (2,399 vs. 560) with more than 80% of DMGs up-methylated in worker larvae. Several highly conserved metabolic and signaling pathways are enriched in methylated genes, underscoring the connection between dietary intake and metabolic flux. This includes genes related to juvenile hormone and insulin, two hormones shown previously to regulate caste determination. We also tie methylation data to expressional profiling and describe a distinct role for one of the DMGs encoding anaplastic lymphoma kinase (ALK), an important regulator of metabolism. We show that alk is not only differentially methylated and alternatively spliced in Apis, but also seems to be regulated by a cis-acting, anti-sense non–protein-coding transcript. The unusually complex regulation of ALK in Apis suggests that this protein could represent a previously unknown node in a process that activates downstream signaling according to a nutritional context. The correlation between methylation and alternative splicing of alk is consistent with the recently described mechanism involving RNA polymerase II pausing. Our study offers insights into diet-controlled development in Apis.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Influence of gene action across different time scales on behavior (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-27
    Description: Genes can affect natural behavioral variation in different ways. Allelic variation causes alternative behavioral phenotypes, whereas changes in gene expression can influence the initiation of behavior at different ages. We show that the age-related transition by honey bees from hive work to foraging is associated with an increase in the expression of the foraging (for) gene, which encodes a guanosine 3',5'-monophosphate (cGMP)-dependent protein kinase (PKG). cGMP treatment elevated PKG activity and caused foraging behavior. Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ben-Shahar, Y -- Robichon, A -- Sokolowski, M B -- Robinson, G E -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):741-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, Neuroscience Program, University of Illinois at Urbana-Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976457" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; *Alleles ; Animals ; Appetitive Behavior ; Bees/*genetics/*physiology ; *Behavior, Animal ; Brain/metabolism ; Cyclic GMP/*analogs & derivatives/pharmacology ; Cyclic GMP-Dependent Protein Kinases/*genetics/metabolism ; Dose-Response Relationship, Drug ; Drosophila/genetics/physiology ; Feeding Behavior ; Gene Expression Profiling ; *Genes, Insect ; Hierarchy, Social ; In Situ Hybridization ; Mushroom Bodies/metabolism ; Phenotype ; RNA, Messenger/genetics/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Social Behavior ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The Anopheles genome and comparative insect genomics (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-05
    Description: The Anopheles gambiae genome sequence, coupled with the Drosophila melanogaster genome sequence, provides a better understanding of the insects, a group that contains our friends, foes, and competitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaufman, Thomas C -- Severson, David W -- Robinson, Gene E -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):97-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Indiana University, Bloomington, IN 47405, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364783" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/anatomy & histology/genetics/growth & development/physiology ; Animals ; Anopheles/anatomy & histology/*genetics/growth & development/physiology ; Bees/anatomy & histology/genetics/growth & development/physiology ; Beetles/genetics ; Behavior, Animal ; Biological Evolution ; Drosophila/genetics/physiology ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genes, Insect ; *Genome ; *Genomics ; Insect Vectors/anatomy & histology/genetics/growth & development/physiology ; Insects/anatomy & histology/*genetics/growth & development/physiology ; Lepidoptera/genetics ; Sequence Analysis, DNA ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Hormonal and genetic control of behavioral integration in honey bee colonies (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-10-06
    Description: The ability of insect colonies to adjust the division of labor among workers in response to changing environmental and colony conditions, coupled with research showing genetic effects on the division of labor in honey bee colonies, led to an investigation of the role of genetics and the environment in the integration of worker behavior. Measurements of juvenile hormone(JH) titers and allozyme analyses of worker honey bees suggest that two processes are involved in colony-level regulation of division of labor: (i) plasticity in age-dependent behavior is a consequence of modulation of JH titers by extrinsic factors, and (ii) stimuli that can affect JH titers and age-dependent behavior do elicit variable responses among genetically distinct subpopulations of workers within a colony. These results provide a new perspective on the developmental plasticity of insect colonies and support the emerging view that colony genetic structure affects behavioral organization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, G E -- Page, R E Jr -- Strambi, C -- Strambi, A -- New York, N.Y. -- Science. 1989 Oct 6;246(4926):109-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17837770" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    From the genome to the proteome: uncovering peptides in the Apis brain (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-10-28
    Description: Neuropeptides, critical brain peptides that modulate animal behavior by affecting the activity of almost every neuronal circuit, are inherently difficult to predict directly from a nascent genome sequence because of extensive posttranslational processing. The combination of bioinformatics and proteomics allows unprecedented neuropeptide discovery from an unannotated genome. Within the Apis mellifera genome, we have inferred more than 200 neuropeptides and have confirmed the sequences of 100 peptides. This study lays the groundwork for future molecular studies of Apis neuropeptides with the identification of 36 genes, 33 of which were previously unreported.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hummon, Amanda B -- Richmond, Timothy A -- Verleyen, Peter -- Baggerman, Geert -- Huybrechts, Jurgen -- Ewing, Michael A -- Vierstraete, Evy -- Rodriguez-Zas, Sandra L -- Schoofs, Liliane -- Robinson, Gene E -- Sweedler, Jonathan V -- DC006395/DC/NIDCD NIH HHS/ -- GM068946/GM/NIGMS NIH HHS/ -- NS31609/NS/NINDS NIH HHS/ -- P30 DA01830/DA/NIDA NIH HHS/ -- P30 DA018310/DA/NIDA NIH HHS/ -- R01 GM068946/GM/NIGMS NIH HHS/ -- R01 NS031609/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2006 Oct 27;314(5799):647-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Illinois, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17068263" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Bees/*chemistry/*genetics ; Brain Chemistry ; Codon ; Computational Biology ; *Genes, Insect ; Genome, Insect ; Insect Proteins/*chemistry/*genetics ; Mass Spectrometry ; Molecular Sequence Data ; Neuropeptides/*chemistry/*genetics ; Protein Precursors/chemistry/genetics ; Proteome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Wasp gene expression supports an evolutionary link between maternal behavior and eusociality (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-09-29
    Description: The presence of workers that forgo reproduction and care for their siblings is a defining feature of eusociality and a major challenge for evolutionary theory. It has been proposed that worker behavior evolved from maternal care behavior. We explored this idea by studying gene expression in the primitively eusocial wasp Polistes metricus. Because little genomic information existed for this species, we used 454 sequencing to generate 391,157 brain complementary DNA reads, resulting in robust hits to 3017 genes from the honey bee genome, from which we identified and assayed orthologs of 32 honey bee behaviorally related genes. Wasp brain gene expression in workers was more similar to that in foundresses, which show maternal care, than to that in queens and gynes, which do not. Insulin-related genes were among the differentially regulated genes, suggesting that the evolution of eusociality involved major nutritional and reproductive pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toth, Amy L -- Varala, Kranthi -- Newman, Thomas C -- Miguez, Fernando E -- Hutchison, Stephen K -- Willoughby, David A -- Simons, Jan Fredrik -- Egholm, Michael -- Hunt, James H -- Hudson, Matthew E -- Robinson, Gene E -- New York, N.Y. -- Science. 2007 Oct 19;318(5849):441-4. Epub 2007 Sep 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. amytoth@uiuc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17901299" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bees/genetics ; *Biological Evolution ; Brain/metabolism ; Female ; *Gene Expression ; Gene Expression Regulation ; *Genes, Insect ; Insect Proteins/genetics/physiology ; *Maternal Behavior ; Models, Animal ; Reproduction ; *Social Behavior ; Wasps/*genetics/metabolism/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Genes and social behavior (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-11-08
    Description: What genes and regulatory sequences contribute to the organization and functioning of neural circuits and molecular pathways in the brain that support social behavior? How does social experience interact with information in the genome to modulate brain activity? Here, we address these questions by highlighting progress that has been made in identifying and understanding two key "vectors of influence" that link genes, the brain, and social behavior: (i) Social information alters gene expression in the brain to influence behavior, and (ii) genetic variation influences brain function and social behavior. We also discuss how evolutionary changes in genomic elements influence social behavior and outline prospects for a systems biology of social behavior.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052688/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052688/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, Gene E -- Fernald, Russell D -- Clayton, David F -- NS045264/NS/NINDS NIH HHS/ -- NS34950/NS/NINDS NIH HHS/ -- R01 GM073644/GM/NIGMS NIH HHS/ -- R01 GM073644-01A1/GM/NIGMS NIH HHS/ -- R01 NS034950/NS/NINDS NIH HHS/ -- R01 NS034950-16A2/NS/NINDS NIH HHS/ -- R01 NS045264/NS/NINDS NIH HHS/ -- R01 NS045264-01/NS/NINDS NIH HHS/ -- R01 NS051820/NS/NINDS NIH HHS/ -- R01 NS051820-10A1/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2008 Nov 7;322(5903):896-900. doi: 10.1126/science.1159277.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of Illinois at Urbana-Champaign, 505 South Goodwin Avenue, Urbana, IL 61801, USA. generobi@illinois.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18988841" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Brain/*physiology ; Environment ; Epigenesis, Genetic ; Gene Expression ; *Genes ; Genetic Variation ; Genotype ; Humans ; *Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Genomics. Beyond nature and nurture (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, Gene E -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):397-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology and Neuroscience Program, University of Illinois, Urbana, IL 61801, USA. generobi@life.uiuc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15087536" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arvicolinae/genetics/physiology ; *Behavior, Animal ; Brain/*metabolism ; Cyclic GMP-Dependent Protein Kinases/genetics/metabolism ; Drosophila melanogaster/genetics/physiology ; *Environment ; Epigenesis, Genetic ; Feeding Behavior ; Gene Expression ; *Genetics, Behavioral ; Maternal Behavior ; Polymorphism, Genetic ; Rats ; Receptors, Glucocorticoid/genetics/metabolism ; Receptors, Vasopressin/genetics/metabolism ; Sexual Behavior, Animal ; Stress, Physiological/genetics/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Development. Sociogenomics takes flight (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, Gene E -- New York, N.Y. -- Science. 2002 Jul 12;297(5579):204-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology and the Neuroscience Program, University of Illinois, Urbana, IL 61801, USA. generobi@uiuc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12114614" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ants/anatomy & histology/*genetics/*growth & development/physiology ; *Biological Evolution ; Body Patterning ; Female ; *Gene Expression ; Gene Expression Profiling ; *Genes, Insect ; Male ; Phenotype ; Selection, Genetic ; Social Behavior ; Species Specificity ; Wings, Animal/anatomy & histology/*growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Gene expression profiles in the brain predict behavior in individual honey bees (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-10-11
    Description: We show that the age-related transition by adult honey bees from hive work to foraging is associated with changes in messenger RNA abundance in the brain for 39% of approximately 5500 genes tested. This result, discovered using a highly replicated experimental design involving 72 microarrays, demonstrates more extensive genomic plasticity in the adult brain than has yet been shown. Experimental manipulations that uncouple behavior and age revealed that messenger RNA changes were primarily associated with behavior. Individual brain messenger RNA profiles correctly predicted the behavior of 57 out of 60 bees, indicating a robust association between brain gene expression in the individual and naturally occurring behavioral plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whitfield, Charles W -- Cziko, Anne-Marie -- Robinson, Gene E -- New York, N.Y. -- Science. 2003 Oct 10;302(5643):296-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of Illinois at Urbana-Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14551438" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Bees/*genetics/metabolism/physiology ; Behavior, Animal ; Brain/metabolism ; DNA, Complementary ; Drosophila melanogaster/genetics ; Expressed Sequence Tags ; Female ; *Gene Expression ; Gene Expression Profiling ; *Genes, Insect ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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