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  • Mice  (112)
  • American Association for the Advancement of Science (AAAS)  (112)
  • American Association of Petroleum Geologists (AAPG)
  • 1975-1979  (112)
  • 1940-1944
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (112)
  • American Association of Petroleum Geologists (AAPG)
  • Springer  (10)
Years
Year
  • 1
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    Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ballou, B -- Levine, G -- Hakala, T R -- Solter, D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):844-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Neoplasm ; Clone Cells/immunology ; Mice ; Neoplasms, Experimental/diagnosis/immunology ; Radionuclide Imaging/*methods ; Teratoma/*diagnosis/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Obesity genes: beneficial effects in heterozygous mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity-diabetes states in homozygotes. These obesity syndromes are characterized by a more efficient conversion of food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, either ob/+ or db/+, survived a prolonged fast significantly longer than normal homozygotes (+/+); this suggests that the heterozygotes exhibited increased metabolic efficiency, a feature normally associated with both homozygous mutants. The existence of this thriftiness trait, if manifested by heterozygous carriers in wild populations, would lend credence to the thrifty gene concept of diabetes. Beneficial effects of normally deleterious genes may have played a role in the development of diabetes-susceptible human populations, as well as having provided the survival advantage that has allowed both the development and successful establishment of species in desert and other less affluent regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coleman, D L -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):663-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760211" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Temperature Regulation ; Diabetes Mellitus, Experimental/*genetics/metabolism ; Fasting ; Glucose/metabolism ; Heterozygote ; Insulin/blood ; Mice ; Mice, Obese/*genetics
    Print ISSN: 0036-8075
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  • 3
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    Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a synergistic effect on the number of cells killed in culture. Methotrexate dose-related increases occur in the concentrations of intracellular 5-fluorouracil ribonucleotides and 5-fluoro-2'-deoxyuridylate and in the incorporation of 5-fluorouracil into RNA. These increases are correlated with increased concentrations of intracellular phosphoribosylpyrophosphate. It is proposed that the enhanced formation of ribonucleotides of 5-fluorouracil and the subsequent incorporation of these compounds into RNA in methotrexate-treated cells may account for synergism between these agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cadman, E -- Heimer, R -- Davis, L -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Drug Administration Schedule ; Drug Synergism ; Fluorouracil/metabolism/*pharmacology ; Leukemia L1210 ; Methotrexate/*pharmacology ; Mice ; Phosphoribosyl Pyrophosphate/metabolism ; RNA, Neoplasm/metabolism ; Ribonucleotides/metabolism ; Thymidylate Synthase/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Seaweed dermatitis: structure of lyngbyatoxin A (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: A highly inflammatory and vesicatory substance, lyngbyatoxin A, has been isolated from the lipid extract of a Hawaiian shallow-water variety of Lyngbya majuscula Gomont; its gross structure was determined from chemical and spectral data. Lyngbyatoxin A is closely related to teleocidin B, a poisonous substance associated with several strains of Streptomyces.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cardellina, J H 2nd -- Marner, F J -- Moore, R E -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107586" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaloids/*toxicity ; Animals ; *Cyanobacteria ; Dermatitis, Contact/*etiology ; *Dermotoxins ; Indoles/toxicity ; *Marine Toxins ; Mice
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Cytidylate cyclase: possible artifacts in the methodology (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaion, R M -- Krishna, G -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):672-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytosine Nucleotides ; Liver/*enzymology ; Lyases/*metabolism ; Mice
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Effect of beta-endorphin on calcium uptake in the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero-Munoz, F -- de Lourdes Guerrero, M -- Way, E L -- Li, C H -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Dose-Response Relationship, Drug ; Drug Tolerance ; Endorphins/antagonists & inhibitors/*pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Neurotransmitter Agents/metabolism ; Rats ; Synaptosomes/*drug effects/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lymphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, L C -- Flier, J -- Itin, A -- Kahn, C R -- Roth, J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):544-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Binding Sites ; Binding Sites, Antibody ; Epitopes ; Female ; Humans ; Liver/analysis ; Lymphocytes/analysis ; Mice ; Placenta/analysis ; Pregnancy ; Radioimmunoassay/methods ; Receptor, Insulin/analysis/*immunology ; Solubility
    Print ISSN: 0036-8075
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  • 8
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    Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: The genetic linkage of the endogenous C3H/HeJ C-type ecotropic virus to phosphoglucomutase-1 (0.28, recombinant fraction) on chromosome 5 was established by means of serological assays of backcrossed mice. With a combination of serological techniques and DNA-DNA hybridization the BALB/c endogenous ecotropic virus was shown to be either closely linked or allelic with the C3H/HeJ locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ihle, J N -- Joseph, D R -- Domotor, J J Jr -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219476" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Genes ; *Genes, Viral ; Genetic Linkage ; Leukemia Virus, Murine/genetics ; Mice ; Mice, Inbred BALB C/*microbiology ; Mice, Inbred C3H/*microbiology ; Mice, Inbred Strains/genetics ; Phenotype ; Phosphoglucomutase/*genetics ; Retroviridae/*genetics
    Print ISSN: 0036-8075
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  • 9
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
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  • 10
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    Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    New drugs and the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):774-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/379998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; France ; History, 20th Century ; Humans ; Mice ; Psychotropic Drugs/*history/metabolism/therapeutic use ; Rats ; Schizophrenia/drug therapy ; United States
    Print ISSN: 0036-8075
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  • 12
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    Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic murine leukemia virus in BALB/c mice, was mapped to chromosome 5, 23 units from the locus for phosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozak, C A -- Rowe, W P -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219475" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Genes, Viral ; Genetic Linkage ; Hybrid Cells/microbiology ; Leukemia Virus, Murine/*genetics ; Mice ; Mice, Inbred BALB C/*microbiology ; Phosphoglucomutase/metabolism ; Virus Replication
    Print ISSN: 0036-8075
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  • 13
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    Angiogenesis in the mouse cornea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: We have developed a method that permits analysis of neovascular responses in the mouse cornea. Using this method we have demonstrated that both allogeneic lymphocytes and a variety of tumors can induce angiogenesis, but that only the latter appear capable of eliciting secondary capillary sprouting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muthukkaruppan, V -- Auerbach, R -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472760" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cornea/*blood supply ; In Vitro Techniques ; Mice ; Mice, Inbred Strains ; Microcirculation ; Neoplasms, Experimental/*blood supply
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  • 14
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    Drug safety: phenacetin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklin, A W -- Welch, R M -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):144, 146, 148.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451584" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; Liver Neoplasms/*chemically induced ; Mice ; Neoplasms, Experimental/chemically induced ; Phenacetin/*adverse effects/standards ; Rats
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  • 15
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    Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Mice with the mutant gene tottering (tg, chromosome 8, autosomal recessive) show, in adolescence, abnormal bursts of bilaterally synchronous spike waves as revealed in electrocorticograms recorded over long periods. The spike waves are accompanied by behavioral "absence" attacks and intermittent focal motor seizures showing somatotopic progression. Cerebral metabolic activity during seizures was assayed by autoradiography of brain sections from mice injected intravenously with 14C-labeled 2-deoxyglucose. Metabolic activity was increased bilaterally in selected brainstem structures. Spontaneous electrocorticographic and clinical seizures of this general pattern were recognized hitherto only in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noebels, J L -- Sidman, R L -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1334-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572084" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Behavior/*physiology ; Brain/growth & development/physiopathology ; Electrocardiography ; Epilepsy/*genetics/physiopathology ; Humans ; Mice ; Mice, Neurologic Mutants/genetics/*physiology ; Neural Pathways/physiopathology ; Seizures/physiopathology ; Stereotyped Behavior/*physiology
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  • 16
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    Methylation of mouse liver DNA studied by means of the restriction enzymes msp I and hpa II (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: The restriction enzymes Hpa II and Msp I both recognize the sequence 5'-CCGG (C, cytosine; G, guanine). However, Hpa II cuts mouse liver DNA to fragments four times larger than does Msp I. The size of DNA cut by Msp I is close to that predicted from base composition and nearest neighbor analysis. The most probable explanation of these results is that in mouse the site 5'-CCGG is highly methylated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singer, J -- Roberts-Ems, J -- Riggs, A D -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1019-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424726" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/*metabolism ; DNA (Cytosine-5-)-Methyltransferase/metabolism ; DNA Restriction Enzymes/metabolism ; Liver/metabolism ; Methylation ; Mice ; Molecular Weight ; Substrate Specificity
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  • 17
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    NCI bioassays yield a trail of blunders (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1287-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay/methods ; *Carcinogens ; Legislation as Topic ; Mice ; *National Institutes of Health (U.S.) ; Research Design/standards ; Research Support as Topic ; United States
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  • 18
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    Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sweeny, G D -- Jones, K G -- Cole, F M -- Basford, D -- Krestynski, F -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):332-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432648" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dioxins/*toxicity ; Enzyme Induction ; Iron/*deficiency ; Liver/pathology ; Mice ; Microsomes, Liver/enzymology ; Mixed Function Oxygenases/metabolism ; Porphyrias/*chemically induced ; Tetrachlorodibenzodioxin/*toxicity ; Uroporphyrinogen Decarboxylase/metabolism
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  • 19
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    Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
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  • 20
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    Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
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  • 21
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    Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatvin, M B -- Clifton, K H -- Dennis, W H -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):195-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451588" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/therapy ; Anesthetics, Local/*therapeutic use ; Animals ; Female ; *Hot Temperature ; Lidocaine/therapeutic use ; Mammary Neoplasms, Experimental/therapy ; Membrane Fluidity/drug effects ; Mice ; Neoplasms, Experimental/*therapy
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  • 22
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    Role of nuclear size in cell growth initiation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Swiss 3T3 cells arrested in B0 (quiescent state) by reducing serum content of the medium all contain the same amount of DNA but vary in nuclear volume over approximately a twofold range. By use of flow microfluorimetry, scatterplots of nuclear volume versus DNA content were obtained in intervals after serum stimulation. The earliest cells to enter DNA synthesis were those with the largest nuclei, whereas cells with the smallest nuclei were among the latest. Regulation of cellular transit from G0 to the S phase was therefore, at least in part, deterministic, since all G0 cells did not have equal probabilities of entry into S at a given moment. All cells having the same nuclear volume did not initiate DNA synthesis at the same moment; therefore, factors other than nuclear volume must also influence this timing. Nuclear volume correlated with the maximum rate at which cells could enter S. The kinetic model of the cell cycle postulating a probabilistic event as solely responsible for entry into S thus appears too simple.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yen, A -- Pardee, A B -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Division ; Cell Nucleus/physiology/*ultrastructure ; Cells, Cultured/*physiology/ultrastructure ; Clone Cells/ultrastructure ; DNA/biosynthesis ; Mice
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  • 23
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    Sporozoite-induced malaria: therapeutic effects of glycolipids in liposomes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (Plasmodium berghei) in mice previously injected with sporozoites. Inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. Inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside GM1. Liposomes containing glycolipids did not inhibit infection transmitted by injecting blood containing erythrocytic stages of malaria. These results may have therapeutic implications in the treatment of malaria. Analysis of the mechanism of interference with the life cycle of malaria by liposomal glycolipids may yield information about the interactions of parasites with cellular membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alving, C R -- Schneider, I -- Swartz, G M Jr -- Steck, E A -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1142-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382358" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ceramides/therapeutic use ; Erythrocytes/parasitology ; Glycolipids/*therapeutic use ; Liposomes/therapeutic use ; Liver/parasitology ; Malaria/parasitology/*therapy ; Mice ; Plasmodium berghei ; Structure-Activity Relationship
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  • 24
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    Chemical carcinogens (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 16;203(4381):602-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens/administration & dosage ; Dose-Response Relationship, Drug ; Mice ; Mutagens ; Neoplasms, Experimental/chemically induced ; Rats ; Vinyl Chloride/*toxicity ; Vinyl Compounds/*toxicity
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  • 25
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    Canine Babesia new to North America (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: A domestic dog residing in New England suffered a fatal febrile illness caused by a Babesia infection. The morphology of these intraerythrocytic protozoa and the range of hosts that could be infected experimentally suggested that the parasite was B. gibsoni. Although this tick-bourne disease is enzootic in wild and domestic Canidae in Africa and Asia, it appears to be new to the Americas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J F -- Magnarelli, L A -- Donner, C S -- Spielman, A -- Piesman, J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1431-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthropod Vectors ; Babesia/classification/cytology ; Babesiosis/epidemiology/*parasitology/transmission ; Cricetinae ; Dog Diseases/*parasitology ; Dogs ; Erythrocytes/parasitology ; Mice ; United States
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  • 26
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    Molecular cloning of polyoma virus DNA in Escherichia coli: lambda phage vector system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: The biological activity of recombinant phage and recombinant phage DNA containing monomeric or dimeric polyoma DNA inserts was examined in mice and cultured mouse cells. Recombinant preparations containing a single copy of viral DNA were invariably noninfectious; molecules containing a dimeric polyoma DNA insert were at least seven orders of magnitude less infectious than polyoma virions after parenteral inoculation. No infection was detected with any recombinant preparation after oral administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, H W -- Israel, M A -- Garon, C F -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):887-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217088" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Coliphages/*genetics ; DNA Restriction Enzymes/metabolism ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; Polyomavirus/*genetics ; Risk ; Tumor Virus Infections/*genetics ; Virus Replication
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  • 27
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    Permeability of the cell-to-cell membrane channels in mammalian cell juncton (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J -- Simpson, I -- Loewenstein, W R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/physiology ; *Cell Membrane Permeability ; Cells, Cultured ; Cricetinae ; Fluorescent Antibody Technique ; Kidney ; Mice ; Mice, Inbred BALB C ; Species Specificity
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  • 28
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    Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Newell, N -- Richards, J -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA, Recombinant ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Liver ; Mice ; Mice, Inbred BALB C ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics ; Transcription, Genetic
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  • 29
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    Phenacetin studies (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaught, J B -- King, C M -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):637, 639.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493967" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Kidney Injury/chemically induced ; Animals ; Biotransformation ; *Carcinogens ; Humans ; Kidney Neoplasms/chemically induced ; Mice ; Mutation ; Phenacetin/*adverse effects/metabolism
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  • 30
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    "Sontaneous" neoplastic transformation in vitro: a form of foreign body (smooth surface) tumorigenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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  • 31
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    Release of luteinizing hormone in male mice during exposure to females: habituation of the response (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coquelin, A -- Bronson, F H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1099-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Diestrus ; Female ; Habituation, Psychophysiologic/*physiology ; Luteinizing Hormone/*metabolism ; Male ; Mice ; Pregnancy ; Sexual Behavior, Animal/physiology
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  • 32
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    A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32--36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This combination of actions is presently unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice; this also is a property of thymopoietin. These results suggest that this readily synthesized pentapeptide corresponds to an active site of thymopoietin and might serve as a therapeutic substitute for thymopoietin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, G -- Scheid, M P -- Boyse, E A -- Schlesinger, D H -- Van Wauwe, J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1309-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451537" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Surface/analysis ; Cell Differentiation/drug effects ; Complement System Proteins ; Isoantigens/analysis ; Lymphocytes/cytology/*immunology ; Mice ; Mice, Nude/immunology ; Oligopeptides/chemical synthesis/*pharmacology ; Receptors, Drug/analysis ; Structure-Activity Relationship ; Thymopoietins/*pharmacology ; Thymus Hormones/*pharmacology
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  • 33
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    Opiate (Enkephalin) receptors of neuroblastoma cells: occurrence in clusters on the cell surface (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: A bioactive, fluorescent derivative of enkephalin, Tyr-D-Ala-Gly-Phe-Leu-Lys-rhodamine, was used to determine the distribution of opiate receptors in living neuroblastoma cells. The receptors appeared in clusters on the cell surface, and no internalization was detected. No specific fluorescence or clusters were observed in the presence of [D-Ala2, Leu5]enkephalin or at 4 degrees C, and the clusters were much reduced under ionic conditions (that is, with 100 millimolars sodium) that specifically decrease the binding of opiate agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Mice ; Microscopy, Fluorescence ; Neoplasms, Experimental/metabolism ; Neuroblastoma/*metabolism ; Receptors, Opioid/*metabolism ; Synaptic Membranes/metabolism
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  • 34
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    Monoclonal antibodies defining distinctive human T cell surface antigens (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kung, P -- Goldstein, G -- Reinherz, E L -- Schlossman, S F -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):347-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/314668" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Antigens, Surface/*analysis ; Cells, Cultured/immunology ; Clone Cells/immunology ; Humans ; Leukemia, Experimental/immunology ; Mice ; Plasmacytoma/immunology ; T-Lymphocytes/*immunology
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    Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcu, K B -- Schibler, U -- Perry, R P -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1087-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; Cell Nucleus/metabolism ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/immunology ; Nucleic Acid Precursors/genetics ; Plasmacytoma/immunology ; Poly A/metabolism ; RNA, Heterogeneous Nuclear/genetics ; *Transcription, Genetic
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    Novel activation mechanism for the promutagenic herbicide diallate (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: The potent bacterial mutagen 2-chloroacrolein is formed from the carcinogenic herbicide S-2,3-dichloroallyl diisopropylthiocarbamate (diallate) on incubation with hepatic microsomal monooxygenases or on reaction with m-chloroperbenzoic acid. A proposed activation mechanism for this promutagen involves sulfoxidation followed by [2,3] sigmatropic rearrangement and 1,2-elimination reactions. A portion of the highly reactive intermediate, diallate sulfoxide (proximate mutagens), is attacked by glutathione in a reaction which competes with its transformation to the ultimate mutagen, 2-chloroacrolein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schuphan, I -- Rosen, J D -- Casida, J E -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1013-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472719" target="_blank"〉PubMed〈/a〉
    Keywords: Acrolein/pharmacology ; Animals ; Biotransformation ; Herbicides/*metabolism/pharmacology ; Mice ; Microsomes, Liver/metabolism ; *Mutagens ; Mutation/drug effects ; Rats ; Thiocarbamates/*metabolism/pharmacology
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    A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paigen, K -- Labarca, C -- Watson, G -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):554-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760204" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Enzyme Induction/drug effects ; Female ; Genes ; *Genes, Regulator ; Genetic Linkage ; Glucuronidase/*genetics ; Hot Temperature ; Kidney/*enzymology ; Mice ; Oocytes/metabolism ; RNA, Messenger/*genetics ; Testosterone/pharmacology ; Xenopus
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    Stress and coping factors influence tumor growth (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-03
    Description: Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated as a result of various stress regimens. A single session of inescapable shock resulted in earlier tumor appearance, exaggeration of tumor size, and decreased survival time in recipient animals. Escapable shock had no such effects. The effects of the inescapable shock were mitigated if mice received long-term shock treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sklar, L S -- Anisman, H -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):513-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electroshock ; Humans ; Male ; Mast-Cell Sarcoma/complications/*physiopathology ; Mice ; Neoplasms, Experimental/complications/physiopathology ; Stress, Psychological/complications/*physiopathology
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  • 39
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    Morphine-naloxone interactions: a role for nonspecific morphine excitatory effects in withdrawal (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: The opiate antagonist naloxone precipitates withdrawal when given either 15 minutes after or 1 minute before a single injection of morphine in drug-naive mice. We propose that withdrawal signs arise from a synergistic mixture of excitatory influences that are direct (agonistic action on nonspecific opiate receptors) and indirect (sensory and affective disorders, stress, hormonal and neurotransmitter dysfunction, and so forth). The predominant effects during precipitated withdrawal are assumed to be direct, whereas during abstinence in tolerant animals they are indirect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stevens, D R -- Klemm, W R -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1379-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224462" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Tolerance ; Female ; Humans ; Mice ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Receptors, Opioid/*drug effects ; Stereotyped Behavior/physiology ; Substance Withdrawal Syndrome/*physiopathology
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    Simultaneous production of Q and R bands after staining with chromomycin A3 or olivomycin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-06
    Description: Human and mouse chromosomes, stained with either chromomycin A3 or olivomycin, which bind preferentially to G - C-rich DNA (where G is guanosine and C is cytosine), exhibit a Q or a reverse banding pattern, depending on the wavelength used for excitation. The two complementary banding patterns can be observed in the same metaphase simply by changing the combination of excitation filters. These data suggest, therefore, that in addition to base composition, other factors are involved in the production of chromosome banding by chromomycin A3 and olivomycin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prantera, G -- Bonaccorsi, S -- Pimpinelli, S -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):79-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cells, Cultured ; Centromere/ultrastructure ; *Chromomycins ; Chromosomes/*ultrastructure ; *Dna ; Fluorescent Dyes ; Humans ; Mice ; *Olivomycins ; Staining and Labeling
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    Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prehn, L M -- Lawler, E M -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):309-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432644" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/genetics/metabolism ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Immunologic ; Female ; Genes ; Male ; *Methylcholanthrene ; Mice ; Mice, Inbred Strains/*physiology ; Sarcoma, Experimental/*chemically induced/immunology
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    Exercise during development induces an increase in Purkinje cell dendritic tree size (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Mice allowed to exercise during the late postnatal period had Purkinje cells with larger dendritic trees and greater numbers of spines than littermates whose physical activity was severly restricted. These changes in Purkinje cells were accompanied by a selective reduction in the thickness of the cerebellar molecular layer. The data provide evidence for cerebellar plasticity during late development and demonstrate that physical activity can modify the development of Purkinje cell dendrites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pysh, J J -- Weiss, G M -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):230-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482938" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Cell Differentiation ; Cerebellar Cortex/growth & development ; Cerebellum/*growth & development ; Dendrites/ultrastructure ; Female ; Male ; Mice ; Motor Activity/physiology ; Physical Exertion ; Purkinje Cells/*cytology
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    Differential competition with cytotoxic agents: an approach to selectivity in cancer chemotherapy (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: An approach to increasing the selectivity of cancer chemotherapeutic agents is presented in which noncytotoxic competitive substrates are used to discern the differences in structural requirements for transport of cytotoxic agents between tumor cells and a sensitive host tissue, the hematopoietic precursor cells of the bone marrow. Examples are given for two such systems, one responsible for the transport of nucleosides and another for the transport of amino acids. Cytidine is twice as effective in reducing the toxicity of showdomycin for murine bone marrow cells in culture as it is for murine L1210 leukemia cella. Conversely, homoleucine is twice as effective in reducing the toxicity of melphalan for L1210 cells as it is for bone marrow cells. These observations can serve as a basis for the development of bone marrow protective agents and for the design of cytotoxic agents that may be preferentially transported into tumor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabinowitz, M -- Uehara, Y -- Vistica, D T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1085-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493993" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibiotics, Antineoplastic/*metabolism ; Biological Transport ; Bone Marrow/drug effects ; Leukemia L1210/drug therapy ; Melphalan/metabolism/therapeutic use ; Mice ; Neoplasms/*drug therapy ; Showdomycin/*metabolism/therapeutic use ; Structure-Activity Relationship
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    6-Hydroxydopamine potentiates acute herpes simplex virus infection of the superior cervical ganglion in mice (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-03
    Description: Treatment of mice with 6-hydroxydopamine increased herpes simplex virus replication in the superior cervical ganglion while it decreased the subsequent prevalence of latent infection. Preganglionic neurectomy failed to block this effect. These observations suggest that intrinsic neural events modify the outcome of viral infections of the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Price, R W -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):518-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221984" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascorbic Acid/pharmacology ; Eye Diseases/immunology ; Female ; Ganglia, Autonomic/drug effects/*microbiology ; Herpes Simplex/immunology ; Hydroxydopamines/*pharmacology ; Immunity ; Mice ; Mice, Inbred BALB C ; Simplexvirus/drug effects/immunology/*pathogenicity
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  • 45
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    ACTH and vasopressin treatments immediately after a defeat increase future submissiveness in male mice (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-22
    Description: Male mice were given a single injection of either adrenocorticotropic hormone (ACTH) or lysine vasopressin immediately after a defeat in an encounter with an aggressive male mouse. The defeated mice were tested for submissiveness at either 24 hours, 48 hours, or 7 days after the initial encounter. Both hormone treatments increased future submissiveness, although the time courses of the effects were different: The effects of ACTH disappeared after 48 hours, whereas those of vasopressin persisted for 7 days. These results suggest that changes in peptide hormone levels following naturally stressful experiences can affect the memory of those experiences, as expressed in future adaptive responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roche, K E -- Leshner, A I -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1343-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221973" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*pharmacology ; Aggression/*drug effects ; Animals ; Behavior, Animal/*drug effects ; Humans ; Lypressin/*pharmacology ; Male ; Mice ; Stress, Psychological/physiopathology
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    Thyroid hormone influence on the susceptibility of mice to audiogenic seizures (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-10
    Description: Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enhanced by treatment with excess thyroxine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seyfried, T N -- Glaser, G H -- Yu, R K -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):598-600.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451624" target="_blank"〉PubMed〈/a〉
    Keywords: *Acoustic Stimulation ; Animals ; Hyperthyroidism/blood ; Hypothyroidism/blood ; Mice ; Mice, Inbred Strains ; Propylthiouracil ; Seizures/*blood ; Thyroxine/*blood/pharmacology
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    Cholecystokinin in the brains of obese and nonobese mice (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-05
    Description: Extracts of the cerebral cortes of genetically obese (ob/ob) mice with hyperphagia contain 0.05 +/- 0.02 microgram (mean +/- standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 +/- 0.01 microgram per gram for their nonobese littermates and 0.20 +/- 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Straus, E -- Yalow, R S -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):68-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758680" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Cholecystokinin/*metabolism ; Mice ; Mice, Obese/*metabolism ; Satiation/physiology
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    Thyroxine increases nerve growth factor concentration in adult mouse brain (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-27
    Description: The effects of thyroxine and propylthiouracil on nerve growth factor concentrations in cerebral cortex, cerebellum, and brainstem of adult male mice were assessed by using a sensitive radioimmunoassay for the beta-subunit of mouse nerve growth factor. Thyroxine administration significantly increased the concentration of nerve growth factor in all three brain areas compared to control values, whereas propylthiouracil was without effect. These results suggest that thyroid hormones stimulate nerve growth factor synthesis in the mature central nervous system, and raise the possibility that the influence of thyroid hormones on central nervous system development might be mediated or influenced by nerve growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, P -- Weichsel, M E Jr -- Fisher, D A -- Guo, S M -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Brain Stem/metabolism ; Cerebellum/metabolism ; Cerebral Cortex/metabolism ; Mice ; Microtubules/metabolism ; Nerve Growth Factors/*metabolism ; Propylthiouracil/pharmacology ; Thyroxine/*pharmacology
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    Carcinogenicity of phenacetin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tomatis, L -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):129-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432634" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Mice ; Neoplasms/*chemically induced ; Phenacetin/*toxicity ; Rats
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  • 50
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    GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-24
    Description: A "recptor unit" for gamma-aminobutyric acid (GABA), which includes brainlike receptor binding sites for tritium-labeled GABA and benzodiazepines (diazepam, clonazepam, and flunitrazepam) and a thermostable endogenous protein (GABA modulin) that inhibits both GABA and benzodiazepine binding, has been demonstrated in membranes prepared from NB2a neuroblastoma and C6 glioma clonal cell lines. In these cells, as in brain, diazepam (1 micromolar) prevents the effect of GABA modulin, and in turn GABA (0.oma and, to a lesser extent, the glioma cells represent a suitable model to study the interactions and the sequence of membrane and intracellular events triggered by the stimulation of benzodiazepine and GABA receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baraldi, M -- Guidotti, A -- Schwartz, J P -- Costa, E -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):821-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Brain/*metabolism ; Cell Line ; Clonazepam/metabolism ; Clone Cells/metabolism ; Diazepam/metabolism/pharmacology ; Flunitrazepam/metabolism ; Membrane Proteins/pharmacology ; Mice ; Nerve Tissue Proteins/pharmacology ; Rats ; Receptors, Drug/*metabolism ; gamma-Aminobutyric Acid/*metabolism
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  • 51
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    How to assess cancer risks (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 May 25;204(4395):811, 813, 815-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Government Agencies ; Humans ; Mice ; Neoplasms/*chemically induced ; Rats ; Risk ; United States
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    Perinatal exposure to cannabinoids alters male reproductive function in mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Oral administration of delta 9-tetrahydrocannabinol or cannabinol to female mice late in pregnancy and during early lactation alters body weight regulation and pituitary-gonadal function and suppresses adult copulatory activity in their male offspring. These findings suggest that both psychoactive and nonpsychoactive constituents of marihuana can affect the development of male reproductive functions in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalterio, S -- Bartke, A -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1420-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472762" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Body Weight/drug effects ; Cannabinoids/*pharmacology ; Cannabinol/*pharmacology ; Copulation/drug effects ; Dronabinol/*pharmacology ; Male ; Mice ; Organ Size/drug effects ; Pituitary Hormones/blood ; Sex Differentiation/*drug effects ; Sexual Behavior, Animal/*drug effects ; Sexual Maturation/drug effects ; Testis/anatomy & histology ; Testosterone/blood
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    Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: A series of recombinant plasmids containing polyoma virus (PY) DNA were constructed, and their biological activity was evaluated in mice and in cultured mouse cells. While all of the recombinants studied contain the complete, potentially infectious viral DNA, in no case was the intact recombinant PY-plasmid DNA, or live Escherichia coli containing the recombinant plasmids, capable of inducing PY infection of mice, either by feeding or by parenteral injection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Israel, M A -- Chan, H W -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):883-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217087" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chromosome Mapping ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; *Plasmids ; Polyomavirus/*genetics ; Transcription, Genetic ; Tumor Virus Infections/*genetics ; Virus Replication
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  • 54
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    Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, G G -- Eisenberg, L R -- Migeon, B R -- New York, N.Y. -- Science. 1979 Jan 12;203(4376):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569362" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Female ; Genetic Linkage ; Humans ; Hybrid Cells/enzymology ; *Hypoxanthine Phosphoribosyltransferase/genetics ; Macromolecular Substances ; Mice ; Molecular Weight ; Protein Conformation ; X Chromosome
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  • 55
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    Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated to 42 degrees C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, J N -- Magin, R L -- Yatvin, M B -- Zaharko, D S -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):188-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432641" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Hot Temperature ; Liposomes/*therapeutic use ; Male ; Metabolic Clearance Rate ; Methotrexate/*administration & dosage/metabolism ; Mice ; Neoplasms, Experimental/*drug therapy ; Phospholipids ; Structure-Activity Relationship
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    Embryonic rodent brain contains estrogen receptors (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Estradiol-binding proteins with the properties of putative estrogen receptors are present in cytosol extracts of embryonic mouse hypothalamus and other brain regions. These embryonic estrogen receptors are adultlike in their high affinity and limited capacity for estradiol, sensitivity to diethylstilbestrol, ability to adhere to DNA, and behavior during DNA-cellulose affinity chromatography. As early as 4 days before birth, mouse hypothalamus has approximately 40 percent of the adult concentration of hypothalamic estrogen receptors with these properties. These observations raise the possibility that embryonic rodent brain has the biochemical potential to respond to sex hormones and that the critical period of brain sexual differentiation could be initiated prenatally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vito, C C -- Fox, T O -- New York, N.Y. -- Science. 1979 May 4;204(4392):517-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432656" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Binding Sites ; Brain/*embryology ; Chromatography, Affinity ; Cytosol/metabolism ; Hypothalamus/embryology ; Mice ; Receptors, Estrogen/*metabolism ; Sexual Maturation
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    Cholinergic vesicles: ability to empty and refill independently of cytoplasmic acetylcholine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: Incubation of minced mouse-forebrain tissues in lithium Krebs solution reduces the acetylcholine content of the vesicular fraction 70 percent without altering that of the cytoplasmic fraction. Depleted vesicular-bound acetylcholine can be restored with newly synthesized acetylcholine (formed from extracellular choline) independently of the cytoplasmic pool. Depletion of vesicular-bound acetylcholine does not facilitate the movement of preformed extracellular acetylcholine into vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carrol, P T -- Nelson, S H -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):85-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Toxicology, University of Rhode Island, Kingston, RI 02881, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569492" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*metabolism ; Animals ; Cholinesterase Inhibitors/pharmacology ; Cytoplasm/*metabolism ; Cytoplasmic Vesicles/drug effects/*metabolism ; Lithium Compounds/pharmacology ; Male ; Mice ; Paraoxon/pharmacology ; Prosencephalon/drug effects/*metabolism/ultrastructure
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    Rabies viruses increase in virulence when propagated in neuroblastoma cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, H F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1072-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628831" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; Mice ; Neuroblastoma/*microbiology ; Neurons/microbiology ; Rabies Vaccines/toxicity ; Rabies virus/genetics/*pathogenicity ; Vaccines, Attenuated/toxicity ; Virus Replication
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    Rejection of male skin grafts by splenectomized female mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: Female mice of the C3H strain normally do not reject skin grafts from males of the same strain; however, 40 percent of splenectomized C3H female mice completely rejected C3H male skin grafts applied 2 weeks later. All splenectomized females showed at least transitory signs of graft rejection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coons, T A -- Goldberg, E H -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/345443" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; *Graft Rejection ; *Histocompatibility Antigens ; Immunosuppression ; Male ; Mice ; Mice, Inbred C3H/immunology ; Skin Transplantation ; Spleen/*immunology ; Transplantation, Homologous ; Y Chromosome
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    Dual actions of substance P on nociception: possible role of endogenous opioids (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higher doses (greater than 50 nanograms per mouse), this activity is lost. At these higher doses, however, substance P produced hyperalgesia when combined with naloxone and analgesia when combined with baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid]. Substance P may have dual actions in brain, releasing endorphins at very low doses and directly exciting neuronal activity in nociceptive pathways at higher doses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frederickson, R C -- Burgis, V -- Harrell, C E -- Edwards, J D -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1359-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204012" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Baclofen/pharmacology ; Dose-Response Relationship, Drug ; Endorphins/*pharmacology ; Enkephalins/antagonists & inhibitors/*pharmacology ; Mice ; Naloxone/pharmacology ; Nociceptors/*drug effects ; Receptors, Opioid/*drug effects ; Structure-Activity Relationship ; Substance P/analogs & derivatives/antagonists & inhibitors/*pharmacology
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    Nicotinamide adenine dinucleotide splitting enzyme: a characteristic of the mouse macrophage (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Murine macrophages are endowed with nicotinamide adenine dinucleotide splitting activity that is markedly higher than that of other cells, tissues, or organs of the mouse. This enzyme therefore can be used as a biochemical marker for distinguishing macrophages from other cells of the lymphoreticular system and from polymorphonuclear leukocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Artman, M -- Seeley, R J -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1293-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214853" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascitic Fluid/enzymology ; B-Lymphocytes/enzymology ; Blood Platelets/enzymology ; Bone Marrow/enzymology ; Humans ; Lymph Nodes/enzymology ; Macrophages/*enzymology ; Mice ; Monocytes/enzymology ; NAD+ Nucleosidase/*metabolism ; Neutrophils/enzymology ; Spleen/enzymology ; T-Lymphocytes/enzymology ; Tissue Distribution
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    Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: Impure and pure samples of saccharin (2 milligrams per milliliter) did not produce oncogenic transformation of C3H/10T1/2, clone 8, mouse embryo fibroblasts. However, after treatment of the cells with a nontransforming initiating dose (0.1 microgram per milliliter) of 3-methylcholanthrene, continuous treatment with either sample of saccharin (100 micrograms per milliliter) led to significant transformation. It is concluded that in this system saccharin is a cocarginogen, probably functioning as a promoting agent that is 1000-fold less active than the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mondal, S -- Brankow, D W -- Heidelberger, C -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1141-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684434" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Cell Line ; Cell Transformation, Neoplastic/*chemically induced ; Cocarcinogenesis ; Embryo, Mammalian ; Methylcholanthrene ; Mice ; Mice, Inbred C3H ; Saccharin/*pharmacology ; Tetradecanoylphorbol Acetate
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    Identification of a C-glucuronide of delta6- tetrahydrocannabinol as a mouse liver conjugate in vivo (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: Delta 6-Tetrahydrocannabinol-C-4-glucuronide was found in the livers of mice that had been administered delta 6-tetrahydrocannabinol. Thus, C-glucuronidation of a compound that contains a free hydroxyl group has been demonstrated in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, S -- Yagen, B -- Mechoulam, R -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663618" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dronabinol/*analogs & derivatives/metabolism ; Glucuronates/metabolism ; Liver/*metabolism ; Mice
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    Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: The inability of nursing pups to survive on milk of mice homozygous for the recessive mutation, lethal milk (lm), is correlated with a reduction in zinc levels of both milk and pup carcass. Administration of zinc to pups nursing on lmlm dams reduces the observed mortality and morbidity. It is suggested that lm alters zinc transport from maternal blood to milk and that its study may provide useful information for understanding the rare human disease, acrodermatitis enteropathica.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piletz, J E -- Ganschow, R E -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; *Lactation ; Mice ; Mice, Inbred C57BL/*genetics ; Milk/*metabolism ; Pregnancy ; Zinc/blood/*deficiency/metabolism
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    Generation of new mouse sarcoma viruses in cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rapp, U R -- Todaro, C -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):821-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210501" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; *Cell Transformation, Neoplastic ; Cell Transformation, Viral ; *Genes, Viral ; Mice ; Retroviridae/genetics/*pathogenicity ; Sarcoma Viruses, Murine/genetics/pathogenicity ; Sarcoma, Experimental/*microbiology
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    Acoustic microscopy: a new window to the world of the small (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1110-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684431" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustics/*instrumentation ; Animals ; Blood Cells/ultrastructure ; Mice ; Microscopy/*instrumentation/methods ; Muscles/ultrastructure ; Myocardium/ultrastructure
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    Prenatal exposure to prednisone in humans and animals retards intrauterine growth (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: Prednisone treatment for infertility and subsequent pregnancy maintenance in humans resulted in a significant decrease in the birth weight of full-term infants and a marked increase in the percentage of newborn infants weighing 2500 grams or less, that is, "light for dates" in comparison to control offspring. A parallel experiment with mice indicated that the reduction of birth weight was caused by exposure to corticosteroids rather than to maternal disease or malfunction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reinisch, J M -- Simon, N G -- Karow, W G -- Gandelman, R -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):436-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705336" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birth Weight/*drug effects ; Female ; Fetus/*drug effects ; Humans ; *Infant, Low Birth Weight ; Infant, Newborn ; Male ; Mice ; Prednisone/*adverse effects ; Pregnancy/*drug effects
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    delta9-tetrahydrocannabinol: antiaggressive effects in mice, rats, and squirrel monkeys (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: delta9-Tetrahydrocannabinol, the most active constituent of marihuana, decreased species-specific attack behavior in mice, rats, and squirrel monkeys at doses (0.25 to 2.0 milligram per kilogram of body weight) that have no effects on other elements of the behavioral repertoire. Aggressive behavior was engendered in all three species by confronting a resident animal with an intruder conspecific. The present results contrast with the widely held belief that marihuana increases aggressive behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miczek, K A -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415367" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*drug effects ; Animals ; Behavior, Animal/*drug effects ; Depression, Chemical ; Dose-Response Relationship, Drug ; Dronabinol/*pharmacology ; Female ; Haplorhini ; Humans ; Male ; Mice ; Motor Activity/drug effects ; Rats ; Saimiri ; Territoriality
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    Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: In weanling mice treated with pharmacologic doses of aminophylline, the concentrations of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in the brain increased 44 and 36 percent, respectively, and the cerebral metabolic rate was three times that in controls. In neonatal mice, therapeutic doses of aminophylline greatly decreased the rate of anoxic survival in vivo and the duration of gasping of the isolated head. The findings suggest caution in the use of this drug and other methylxanthines in hypoxic human newborns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, J H -- Hauhard, R E -- Dirgo, J A -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/209541" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/metabolism ; Aminophylline/*pharmacology/therapeutic use ; Animals ; Anoxia/physiopathology ; Apnea/drug therapy ; Brain/drug effects/*metabolism ; Cheyne-Stokes Respiration/drug therapy ; Cyclic AMP/metabolism ; Energy Metabolism/*drug effects ; Glucose/metabolism ; Glucosephosphates/metabolism ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/drug therapy ; Mice
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
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  • 71
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    Effect of oxygen pressure during culture on survival of mouse thyroid allografts (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: A marked increase in the percentage of mouse thyroids that retained function 20 days after transplantation across a major histocompatibility barrier and the percentage that lacked generalized infiltration was observed when the grafts received hyperbaric oxygen during a 4-day culture period. Perfusion of the donor animal before thyroidotomy and the addition of fetal calf serum to the culture medium did not have a significant effect on graft survival, but the percentage of grafts lacking generalized infiltration was slightly increased by the addition of hydrocortisone to the culture medium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmage, D W -- Dart, G A -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1066-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653355" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood ; Culture Media ; *Graft Survival/drug effects ; Hydrocortisone/pharmacology ; *Hyperbaric Oxygenation ; Mice ; Organ Culture Techniques/*methods ; Thyroid Gland/*transplantation ; Transplantation, Homologous
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  • 72
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    Pierce's disease of grapevines: isolation of the causal bacterium (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: A Gram-negative, rod-shaped bacterium has been consistently isolated from grapevines with Pierce's disease. Grapevines inoculated with the bacterium developed Pierce's disease, and the bacterium was reisolated from the plants. The bacterium was serologically and ultrastructurallv indistinguishable from the one in naturally infected plants, and also indistinguishable from a bacterium isolated from almonds with almond leaf scorch disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M J -- Purcell, A H -- Thomson, S V -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):75-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Pathology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569487" target="_blank"〉PubMed〈/a〉
    Keywords: Agglutination Tests ; Animals ; Cell Wall/ultrastructure ; Gram-Negative Bacteria/cytology/immunology/*isolation & ; purification/pathogenicity ; Hemiptera/microbiology ; Insect Vectors/microbiology ; Male ; Mice ; Plant Diseases/*microbiology ; Prunus/microbiology ; Rabbits ; Vitis/*microbiology
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  • 73
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    (S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: (S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Clercq, E -- Descamps, J -- De Somer, P -- Holy, A -- New York, N.Y. -- Science. 1978 May 5;200(4341):UNKNOWN.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205946" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/*analogs & derivatives/pharmacology ; Animals ; *Antiviral Agents ; Cytopathogenic Effect, Viral/drug effects ; Female ; Measles virus/drug effects ; Mice ; Simplexvirus/drug effects ; Vaccinia virus/drug effects ; Vesicular stomatitis Indiana virus/drug effects ; Virus Replication/*drug effects
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  • 74
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    Ethanol: modifications of acute intoxication by divalent cations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, C K -- Tyler, T D -- Harris, R A -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/343251" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholic Intoxication/*physiopathology ; Animals ; Body Temperature Regulation/drug effects ; Calcimycin/pharmacology ; Calcium/antagonists & inhibitors/*physiology ; Cations, Divalent ; Dose-Response Relationship, Drug ; Drug Synergism ; Female ; Humans ; Lasalocid/pharmacology ; Male ; Mice ; Movement/drug effects ; Rats
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  • 75
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    Sustained release of alcohol: subcutaneous silastic implants in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: A sustained-release device for use in ethanol dependence studies in mice is described. The Silastic device, dubbed SERT (sustained ethanol release tube), holds 0.35 milliliter of 95 percent ethanol (by volume) and is implanted under the skin of the back where it releases ethanol for up to 12 hours, with no observable tissue damage. The device may be adaptable to the release of other volatile liquids or drugs, in other animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, C K -- Koch, K I -- Mehta, C S -- McGinity, J W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564551" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholic Intoxication/etiology ; Alcoholism/*etiology ; Animals ; *Disease Models, Animal ; Drug Administration Schedule ; Drug Implants ; Drug Tolerance ; Ethanol/*administration & dosage ; Humans ; Mice ; Silicone Elastomers
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  • 76
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    Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: HIX virus cloned from Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis of several virus stocks and the examination of virus progeny from individual foci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischinger, P J -- Blevins, C S -- Dunlop, N M -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Genes, Viral ; Glycoproteins/immunology ; Leukemia, Experimental/*microbiology ; Lymphoma/*microbiology ; Mice ; Mice, Inbred BALB C/microbiology ; Mice, Inbred Strains/microbiology ; Moloney murine leukemia virus/classification/*genetics/immunology ; Recombination, Genetic ; Species Specificity ; Viral Proteins/immunology
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  • 77
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    Memory: modification of anisomycin-induced amnesia by stimulants and depressants (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-20
    Description: Mice were trained in a passive (foot shock)avoidance task. When administered after training, the stimulants caffeine or nicotine blocked amnesia for the task that had been produced by injections of the protein synthesis inhibitor anisomycin given prior to training. With foot shock at a higher intensity, anisomycin did not produce amnesia by itself, but the administration of the depressants chloral hydrate or sodium phenobarbital after training did cause amnesia. Stimulants and depressants did not have an appreciable influence on the overall degree of protein synthesis inhibition produced by anisomycin. The results support the hypothesis that arousal after training is an important factor in the conversion of short-term to long-term memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flood, J F -- Bennett, E L -- Orme, A E -- Rosenzweig, M R -- Jarvik, M E -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):324-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619461" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anisomycin/*pharmacology ; Avoidance Learning/*drug effects ; Brain/*drug effects ; Caffeine/pharmacology ; Chloral Hydrate/pharmacology ; Drug Interactions ; Male ; Memory/*drug effects ; Mice ; Nerve Tissue Proteins/biosynthesis ; Nicotine/pharmacology ; Phenobarbital/pharmacology ; Pyrrolidines/*pharmacology
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    A nonpeptide morphine-like compound: immunocytochemical localization in the mouse brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: A nonpeptide morphine-like compound (MLC) which cross reacts with morphine-specific antibodies has been localized with the use of immunocytochemistry. This morphine-like compound is found in neuronal perikarya or processes (or both) in nuclei related to vestibular, cerebellar, and raphe systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gintzler, A R -- Gershon, M D -- Spector, S -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):447-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/339350" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain Chemistry ; Cerebellum/analysis ; Cerebral Aqueduct/analysis ; Cross Reactions ; Immunoenzyme Techniques ; Mice ; Morphine/*immunology ; Raphe Nuclei/analysis ; Vestibular Nuclei/analysis
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  • 79
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    Another flame retardant, tris-(1,3-dichloro-2-propyl)-phosphate, and its expected metabolites are mutagens (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the Salmonella-mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant, 1,3-dichloro-2-propanone, is a potent mutagen in the absence of such activation. A flame retardant with similar structure, tris-(2,3-dibromopropyl)phosphate (tris-BP), was shown previously to be a mutagen, to cause sterility in animals, to be a carcinogen, and to be absorbed through human skin. These and other flame retardants have characteristic nuclear magnetic resonance spectra that can be used to determine which flame retardant is present in commercially purchased sleepwear. Sleepwear treated with tris-BP, Fyrol FR2, and other chemical additives was being sold in late 1977.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, M D -- Blum, A -- Ames, B N -- New York, N.Y. -- Science. 1978 May 19;200(4343):785-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347576" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotransformation ; Flame Retardants/*toxicity ; Hydrocarbons, Chlorinated/toxicity ; Liver/metabolism ; Mice ; *Mutagens ; Organophosphorus Compounds/*toxicity ; Salmonella typhimurium/drug effects ; Structure-Activity Relationship
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  • 80
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    Endosteal marrow: a rich source of hematopoietic stem cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: Hematopoietic cells isolated from the endosteal bone surface, that is,the endosteal marrow cells, were found to consist mainly (60 to 80 percent) of lymphoid and late-stage normoblast-like cells. Unlike the cells they resemble, the endosteal marrow cells showed an affinity for Sudan black, demonstrable nucleoli (Feulgen reaction), and an absence of hemoglobin. Assays showed that over one-half of the endosteal marrow cell population may be the colony-forming units, the CFU-S of Till and McCulloch. Thus, high concentrations of stem cells could be obtained from the endosteal bone surface by means of the present isolation technique.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gong, J K -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1443-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/75570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Cells ; Cell Nucleolus/ultrastructure ; Female ; Hematopoiesis ; Hematopoietic Stem Cells/*cytology ; Lymphocytes/ultrastructure ; Male ; Mice ; Rats ; Spleen/cytology ; Staining and Labeling
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  • 81
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    Retrograde amnesia produced by several treatments: evidence for a common neurobiological mechanism (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the alpha-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, P E -- Sternberg, D B -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208153" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/*etiology ; Amnesia, Retrograde/*etiology/prevention & control ; Amygdala/physiopathology ; Animals ; Avoidance Learning/drug effects ; Cerebral Cortex/physiopathology ; Cycloheximide/antagonists & inhibitors ; Ditiocarb/antagonists & inhibitors ; Electric Stimulation ; Humans ; Memory/*drug effects ; Mice ; Phenoxybenzamine/*pharmacology ; Rats ; Seizures/complications
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  • 82
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    Rod-cone dysplasia in Irish setters: a defect in cyclic GMP metabolism in visual cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: An abnormality in retinal guanosine 3,5-monophosphate (cyclic GMP) metabolism is demonstrated in the inherited rod-cone dysplasis of Irish Setter dogs. Affected visual cells are deficient in cyclic GMP phosphodiesterase activity and have elevated levels of cyclic GMP. The biochemical abnormalities observed in affected retinas of Irish Setters are similar to those in the retinas of mice with inherited retinal degeneration before visual cell degeneration begins. A defect in cyclic GMP metabolism may be characteristic of early-onset degenerative diseases of the retina, possibly including those that affect humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aquirre, G -- Farber, D -- Lolley, R -- Fletcher, R T -- Chader, G J -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1133-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210508" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-GMP Phosphodiesterases/*deficiency ; Animals ; Cell Differentiation ; Chromosome Aberrations/genetics/metabolism/pathology/veterinary ; Chromosome Disorders ; Cyclic GMP/*metabolism ; Dog Diseases/genetics/*metabolism/pathology ; Dogs ; Kinetics ; Mice ; Photoreceptor Cells/metabolism/pathology ; Retina/enzymology/*metabolism/pathology ; Retinal Degeneration/genetics/metabolism/pathology/*veterinary
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  • 83
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Shotgun collections of Charon 3A bacteriophages containing Eco RI fragments of human and mouse DNA were constructed with the use of in vitro packaging. Plaques were screened by hybridization, and globin-specific clones were isolated from both human (Charon 3AHs51.1) and mouse (Charon 3AMm30.5). The fragments cloned were detected in unfractionated genomic DNA by the Southern method of hybridization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blattner, F R -- Blechl, A E -- Denniston-Thompson, K -- Faber, H E -- Richards, J E -- Slightom, J L -- Tucker, P W -- Smithies, O -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1279-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725603" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coliphages/genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Fetal Hemoglobin/genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; Poly A ; Poly T
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  • 84
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    Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurland, J I -- Bockman, R S -- Broxmeyer, H E -- Moore, M A -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/304600" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Colony-Stimulating Factors/*physiology ; Feedback ; Glycoproteins/*physiology ; Granulocytes/*cytology ; *Hematopoiesis ; Humans ; Leukocytes/*cytology ; Macrophages/cytology/*physiology ; Mice ; Models, Biological ; Monocytes/*physiology ; Prostaglandins E/*physiology
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  • 85
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    Enkephalin-containing neurons visualized in spinal cord cell cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Neuronal cells, axons, and terminals containing immunoreactive enkephalin have been visualized in cultures of dissociated fetal spinal cord. These cultures may provide a valuable system in which to explore the effects of chronic drug treatment on the physiology of enkephalin-containing cells and their interactions with other cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neale, J H -- Barker, J L -- Uhl, G R -- Snyder, S H -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):467-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351811" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/metabolism ; Cells, Cultured ; Cytoplasm/metabolism ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Fluorescent Antibody Technique ; Ganglia, Spinal/metabolism ; Mice ; Neurons/*metabolism ; Spinal Cord/cytology/embryology/*metabolism
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  • 86
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    Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Reovirus type 3, passaged in pancreatic beta-cell cultures, produced an insulitis when inoculated into 1- to 2-week-old mice. By means of a double-label antibody technique, in which we used fluorescein-labeled antibody to reovirus and rhodamine-labeled antibody to insulin, reovirus antigens were found in beta cells. By electron microscopy, viral particles in different stages of morphogenesis were observed in insulin-containing beta cells but not glucagon-containing alpha cells. The infection resulted in destruction of beta cells, reduction in the insulin content of the pancreas, and alteration in the host's capacity to respond normally to a glucose tolerance test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onodera, T -- Jenson, A B -- Yoon, J W -- Notkins, A L -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):529-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208156" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/analysis ; Cells, Cultured ; Diabetes Mellitus, Experimental/etiology/metabolism/*microbiology ; Diabetes Mellitus, Type 1/microbiology ; Insulin/metabolism ; Islets of Langerhans/metabolism/*microbiology ; Mammalian orthoreovirus 3/immunology ; Mice ; Reoviridae Infections/*complications ; Virus Replication
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  • 87
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    delta9-Tetrahydrocannabinol and 17beta-estradiol bind to different macromolecules in estrogen target tissues (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: delta9-Tetrahydrocannabinol (delta9-THC), added to the limit of its solubility, did not compete with tritiated 17beta-estradiol for binding to estrogen receptor sites in mouse mammary or uterine cytosols. On sucrose density gradients of low-ionic strength, mammary cytosol labeled with [3H]estradiol exhibited a binding peak near the "8S" region typical of estrogen receptor whereas in cytosol labeled with delta9-[3H]THC binding was limited to the nonspecific 4- to 5S region. Differences in sedimentation properties and reciprocal competition studies strongly refute previous claims that delta-9-THC binds to estrogen receptor and that by so doing it directly acts as an estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okey, A B -- Bondy, G P -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):312-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635586" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Cytosol/metabolism ; Dronabinol/*metabolism ; Estradiol/*metabolism ; Female ; Mammary Glands, Animal/metabolism ; Mice ; Molecular Weight ; Receptors, Drug/*metabolism ; Receptors, Estrogen/isolation & purification/*metabolism ; Uterus/metabolism
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  • 88
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    Visualization of a guinea pig T lymphocyte surface component cross-reactive with immunoglobulin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: Thymus-derived lymphocytes (T cells) show exquisite specificity in recognition of antigens, but the nature of the cell surface receptor is controversial. Although antigen recognition mediated by immunoglobulin variable (V) regions remains the minimal hypothesis, it has been extremely difficult to definitely establish the presence of immunoglobulins on these cells. Chicken antibodies, produced against the (Fab')2fragment of mouse immunoglobulin G (IgG) and purified by binding to and elution from IgG-Sepharose 4B, bind to an endogenously synthesized surface component of guinea pig T cells. The binding occurred via a cross-reaction with murine k chain and a heavy chain determinant localized in the Fd region, and was visualized by immunofluorescence and immunoelectronmicroscopy using both transmission and scanning techniques. These data provide direct evidence for the presence of a surface component related to immunoglobulin on T lymphocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marchalonis, J J -- Bucana, C -- Hoyer, L -- Warr, G W -- Hanna, M G Jr -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):433-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/74094" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cross Reactions ; Epitopes ; Guinea Pigs ; Immunoglobulin Fab Fragments ; Immunoglobulin G ; Immunologic Techniques ; Mice ; Receptors, Antigen, B-Cell/*analysis ; Rosette Formation ; Species Specificity ; T-Lymphocytes/*immunology ; Thymus Gland/immunology
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  • 89
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    beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa) (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margules, D L -- Moisset, B -- Lewis, M J -- Shibuya, H -- Pert, C B -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):988-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Eating/drug effects ; Endorphins/antagonists & inhibitors/blood/*physiology ; Feeding Behavior/*physiology ; Female ; Male ; Mice ; Mice, Obese/*physiology ; Naloxone/pharmacology ; Obesity/genetics/*physiopathology ; Pituitary Gland/physiology ; Rats
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  • 90
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    Ultraviolet radiation--induced chromosomal abnormalities in fetal fibroblasts from New Zealand black mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: Fibroblasts from New Zealand Black mouse fetuses manifest increased frequency of chromosomal breaks and interchanges after exposure to ultraviolet radiation when compared with cells from BABL/c fetuses. This chromosomal instability is similar to what has been reported in cells from patients with xeroderma pigmentosum and may be related to the chromosomally abnormal clones and malignancy previously reported in adult New Zealand Black mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, A L -- Fialkow, P G -- Salo, A -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):920-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; *Chromosome Aberrations ; Chromosomes/*radiation effects ; Disease Models, Animal ; Dose-Response Relationship, Radiation ; Mice ; Mice, Inbred BALB C/physiology ; Mice, Inbred NZB/*physiology ; *Ultraviolet Rays ; Xeroderma Pigmentosum/physiopathology
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  • 91
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    The LDH virus: an interfering biological contaminant (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- Spackman, D H -- Santisteban, G A -- Dalldorf, G -- Hellstrom, I -- Hellstrom, K E -- Lance, E M -- Rowson, K E -- Mahy, B W -- Alexander, P -- Stock, C C -- Sjogren, H O -- Hollander, V P -- Horzinek, M C -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):124-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/263259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Lactate dehydrogenase-elevating virus ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/microbiology ; Virus Diseases/microbiology
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  • 92
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    6-Mercaptopurine treatment of pregnant mice: effects on second and third generations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reimers, T J -- Sluss, P M -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663638" target="_blank"〉PubMed〈/a〉
    Keywords: 6-Mercaptopurine/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Fetal Death/*chemically induced ; Fetus/drug effects ; Germ Cells/*drug effects ; Infertility, Female/*chemically induced ; Litter Size/drug effects ; Mice ; Ovary/cytology/drug effects/embryology ; Pregnancy ; Pregnancy, Animal/*drug effects
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  • 93
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    Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells. Receptor agonists for H1, but not H2, caused this effect which was reduced by H1 but not by H2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H1 receptors in these cultured nerve cells stimulated cyclic GMP formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richelson, E -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/pharmacology ; Carbachol/pharmacology ; Cell Line ; Cyclic GMP/*metabolism ; Histamine/*pharmacology ; Histamine H1 Antagonists/pharmacology ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Receptors, Histamine/*drug effects ; Receptors, Histamine H1/*drug effects
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  • 94
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    Morphological alterations in hippocampus after long-term alcohol consumption in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Golgi methods were used to examine the hippocampus of laboratory mice that received alcohol-containing or control diets for 4 months followed by a 2-month alcohol-free period. Long-term alcohol consumption resulted in a significant loss of dendritic spines on hippocampal pyramidal cells and dentate granule cells. This study provides evidence that long-term alcohol consumption, in the absence of malnutrition, produces morphological damage to the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, J N -- Walker, D W -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):646-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566953" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*pathology ; Animals ; Dendrites/ultrastructure ; *Disease Models, Animal ; Female ; Hippocampus/*pathology ; Humans ; Mice ; Pyramidal Tracts/pathology
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  • 95
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    Membrane potentials of mitochondria (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rottenberg, H -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Energy Metabolism ; *Membrane Potentials/drug effects ; Mice ; Microelectrodes ; Mitochondria/*physiology ; Valinomycin/pharmacology
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  • 96
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    Prevention of death from metastases by immune RNA therapy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: The effect of immune RNA treatment on the incidence of death from pulmonary metastases was studied in C57BL/6J mice after excision of a B16 murine melanoma. Immune RNA was extracted from the lymphoid tissues of guinea pigs immunized with B16 tumor and then incubated in vitro with normal C57BL/6J mouse splenocytes. Mice receiving intraperitoneal injections of these RNA-treated syngeneic splenocytes after the primary B16 isograft was resectioned showed significantly improved long-term survival (42 to 67 percent in three successive experiments) as compared to control mice (0 to 20 percent survival) receiving untreated splenocytes. The effect of RNA treatment was tumor-specific and ribonuclease sensitive. The results suggest that immunotherapy with immune RNA may be of benefit to certain patients after surgery for cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, B S -- Onikul, S R -- Mannick, J A -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):59-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694519" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Immunotherapy/methods ; Lung Neoplasms/prevention & control ; Lymphocytes/*immunology ; Melanoma/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/*prevention & control ; Neoplasms, Experimental/immunology ; RNA/immunology/*therapeutic use ; Spleen/immunology
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  • 97
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    Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: The adenosine 3',5'-monophosphate (cyclic AMP) levels of mouse lymphocytes rose and fell sharply 10 hours after stimulation with concanavalin A. Treatment of the cells with indomethacin reversibly prevented the increase in cyclic AMP and the subsequent onset of DNA synthesis. When the heightened cyclic AMP before S phase was maintained by either inhibiting phosphodiesterase or by adding the 8-bromo derivative of cyclic AMP, DNA synthesis was also blocked. Both the increase and decrease in cyclic AMP appear to be required for progression of lymphocytes into the S phase of growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, T -- Sheppard, J R -- Foker, J E -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208147" target="_blank"〉PubMed〈/a〉
    Keywords: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacology ; Animals ; Cell Cycle/drug effects ; *Cell Division/drug effects ; Concanavalin A/antagonists & inhibitors ; Cyclic AMP/analogs & derivatives/*metabolism/pharmacology ; DNA/*biosynthesis ; Indomethacin/pharmacology ; *Lymphocyte Activation/drug effects ; Lymphocytes/*metabolism ; Mice ; RNA/biosynthesis ; Spleen/cytology
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  • 98
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    Genetic mapping of xenotropic leukemia virus-inducing loci in two mouse strains (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: In genetic studies of C57BL/10 and BALB/c mice, inducibility of xenotropic murine leukemia virus from tissue cultures by treatment with 5-iododeoxyuridine shows single gene segregation ratios. In both strains, the virus-inducing loci are on chromosome 1, linked to the Dip-1/isozyme locus, but the two may not be at allelic sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozak, C -- Rowe, W P -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1448-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Genes ; Genetic Linkage ; Idoxuridine/pharmacology ; Leukemia Virus, Murine/*genetics ; Mice ; Mice, Inbred BALB C/*genetics ; Mice, Inbred C57BL/*genetics ; *Virus Replication/drug effects
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  • 99
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    Binding of benzo[a]pyrene 7,8-diol-9,10-epoxides to DNA, RNA, and protein of mouse skin occurs with high stereoselectivity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: The formation, stereostructure, and cellular reactions of the 7,8-diol-9,10-epoxide metabolites of the carcinogen benzo[a]pyrene have been examined after topical application of benzo[a]pyrene to the skin of mice. In this known target tissue, polymer adducts from diastereomeric diol epoxides, (+)-(7S, 8R, 9R, 10R) and (+)-(7R, 8S, 9R, 10R), were formed stereospecifically from their corresponding 7,8-dihydrodiols. Both diol epoxides bind with proteins, RNA, and DNA in vivo. For the nucleic acids, binding occurs preferentially at the 2-amino group of guanine in cellular RNA and DNA in vivo. Methods for establishing the structure of the cellular adducts as well as the possible biological implications of their formation are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koreeda, M -- Moore, P D -- Wislocki, P G -- Levin, W -- Yagi, H -- Jerina, D M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):778-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622566" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzopyrenes/*metabolism ; Chromatography, High Pressure Liquid ; DNA/*metabolism ; Epoxy Compounds/metabolism ; Female ; Mice ; Mice, Inbred C57BL ; Molecular Conformation ; Proteins/*metabolism ; RNA/*metabolism ; Skin/*metabolism ; Stereoisomerism
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  • 100
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    Chick embryonic skin as a rapid organ culture assay for cellular neoplasia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: We used chick embryonic skin (CES) in organ culture to assess the neoplastic potential of a variety of cultured human and nonhuman cell lines. Cells derived from cancer tissues grew in CES and formed tumors in nude mice while cells derived from normal tissues grew in neither system. The CES proved to be more sensitive than the nude mouse when used to assay SV40 transformed human cells; each of four such lines grew in CES while only one of the four lines grew and formed tumors in nude mice. In addition, the patterns of invasion by inoculated cells can be easily studied in the CES. These results suggest that CES in organ culture offers an inexpensive, rapid, and reliable alternative to the nude mouse as a tumorigenicity test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, P D -- Johnson, J B -- O'Donnell, R -- Petricciani, J C -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):980-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Line ; Cell Survival ; *Cell Transformation, Neoplastic ; *Chick Embryo/metabolism ; Mice ; Mice, Nude ; Mitosis ; Neoplasm Invasiveness ; Neoplasms/*metabolism/pathology ; *Organ Culture Techniques ; Simian virus 40 ; Skin/*embryology/metabolism/pathology
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