Abstract
Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.
MeSH terms
-
Animals
-
Aryl Hydrocarbon Hydroxylases / genetics
-
Aryl Hydrocarbon Hydroxylases / metabolism
-
Dose-Response Relationship, Drug
-
Dose-Response Relationship, Immunologic
-
Female
-
Genes
-
Male
-
Methylcholanthrene*
-
Mice
-
Mice, Inbred Strains / physiology*
-
Sarcoma, Experimental / chemically induced*
-
Sarcoma, Experimental / immunology
Substances
-
Methylcholanthrene
-
Aryl Hydrocarbon Hydroxylases