Publication Date:
1978-07-28
Description:
This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the alpha-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, P E -- Sternberg, D B -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208153" target="_blank"〉PubMed〈/a〉
Keywords:
Amnesia/*etiology
;
Amnesia, Retrograde/*etiology/prevention & control
;
Amygdala/physiopathology
;
Animals
;
Avoidance Learning/drug effects
;
Cerebral Cortex/physiopathology
;
Cycloheximide/antagonists & inhibitors
;
Ditiocarb/antagonists & inhibitors
;
Electric Stimulation
;
Humans
;
Memory/*drug effects
;
Mice
;
Phenoxybenzamine/*pharmacology
;
Rats
;
Seizures/complications
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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