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  • Rats  (150)
  • Cells, Cultured  (47)
  • American Association for the Advancement of Science (AAAS)  (189)
  • 1995-1999
  • 1980-1984  (189)
  • 1975-1979
  • 1983  (189)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (189)
  • Springer  (1)
Years
  • 1995-1999
  • 1980-1984  (189)
  • 1975-1979
Year
  • 1
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    Homeostasis of the antibody response: immunoregulation by NK cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-11
    Description: When injected into mice, the synthetic double-stranded polynucleotide poly(inosinic) X poly(cytidylic) acid induces high natural killer (NK) cell activity within 4 to 12 hours. Induction of NK activity in mice immunized 2 or 3 days previously, or the addition of NK cells to cultures immunized in vitro 2 or 3 days previously, promotes early termination of the ongoing primary immunoglobulin M antibody response. A target for NK cells is a population of accessory cells that has interacted with antigen and is necessary for sustaining the antibody response. The inference is strong that NK cells induced normally by immunization also terminate the usual antibody response in vivo by elimination of antigen-exposed accessory cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abruzzo, L V -- Rowley, D A -- 5-T32-CA-09267/CA/NCI NIH HHS/ -- R01-10242/PHS HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):581-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6685343" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Formation ; Antibody-Producing Cells/immunology ; Cells, Cultured ; Homeostasis ; Killer Cells, Natural/*immunology/radiation effects ; Lymphocyte Cooperation ; Lymphocytes/*immunology ; Mice ; Poly I-C/immunology ; Spleen/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Burst discharge in mammalian neuroendocrine cells involves an intrinsic regenerative mechanism (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrew, R D -- Dudek, F E -- NS 16877/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1050-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879204" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Electrophysiology ; Evoked Potentials ; Feedback ; Hypothalamus/cytology ; In Vitro Techniques ; Membrane Potentials ; Neurosecretory Systems/cytology/*physiology ; Rats ; Tetrodotoxin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Primary murine bone marrow cultures support continuous growth of infectious human trypanosomes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-22
    Description: The human parasite Trypanosoma brucei gambiense grew continuously at 37 degrees C in primary cultures of murine bone marrow. Cultured parasites remained virulent for mice. Rapid parasite growth coincided with the appearance of adherent adipocyte-epitheloid cell aggregates that also promoted hematopoiesis. This culture system should permit studies of host cell control of trypanosome proliferation, pathogenic effects of trypanosomes on blood cell development, and the relative trypanocidal and marrow suppressive activities of drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balber, A E -- CA 14049/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836284" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow ; Cells, Cultured ; Culture Media ; Humans ; Mice ; Mice, Inbred BALB C ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei gambiense/*growth & development ; Trypanosomiasis, African/parasitology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Regulation of carcinogen metabolism in the rat ovary by the estrous cycle and gonadotropin (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: The activity of 7,12-dimethylbenz[a]anthracene hydroxylase in the rat ovary is several times higher in the proestrous phase of the estrous cycle than in the estrous and metestrous plus diestrous phases. Administration of gonadotropin leads to a similar increase in the capacity of the ovary to metabolize xenobiotics. This variation in the activity of 7,12-dimethylbenz[a]anthracene hydroxylase during the estrous cycle may be related to the marked changes in the incidence of ovarian cancer during menopause and in women taking contraceptive pills.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bengtsson, M -- Rydstrom, J -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681915" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/*metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Epoxide Hydrolases/metabolism ; *Estrus ; Female ; Glutathione Transferase/metabolism ; Gonadotropins, Equine/*pharmacology ; Metestrus ; Ovary/*physiology ; Pregnancy ; Proestrus ; Quinone Reductases/metabolism ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Time course of alpha-flupenthixol action explains "response artifacts" of neuroleptic action on brain stimulation reward (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 16;222(4629):1251-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Flupenthixol/*pharmacology ; Hypothalamus/*drug effects ; Kinetics ; Rats ; *Reward ; Self Stimulation/*drug effects ; Thioxanthenes/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Pimozide blocks establishment but not expression of amphetamine-produced environment-specific conditioning (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-17
    Description: Animals with a history of receiving daily injections of +-amphetamine in a specific environment showed a placebo effect (enhanced activity) when injected with saline and placed there; control animals with similar but dissociated drug histories and experience with the test chamber failed to show the effect. The dopamine receptor blocker pimozide antagonized the establishment of conditioning. However, the same dose of pimozide, when given to previously conditioned animals on the placebo test day, failed to antagonize the expression of conditioned activity. Thus, during conditioning dopaminergic neurons mediated a change that subsequently influenced behavior even when dopaminergic systems were blocked. Although schizophrenia may be related to hyperfunctioning of dopamine, neuroleptic drugs, which block dopamine receptors on their first administration, do not have therapeutic effects for a number of days. The results of the pimozide experiments may resolve this paradox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beninger, R J -- Hahn, B L -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology)/*drug effects/physiology ; Dextroamphetamine/antagonists & inhibitors/*pharmacology ; Humans ; Male ; Pimozide/*pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/physiology ; Reinforcement (Psychology) ; Schizophrenia/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-19
    Description: Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of adjuvant rats treated with 13-cis-retinoic acid also decreased as compared to the amount secreted by cells from vehicle-treated adjuvant rats. Collagenase is important in the joint destruction accompanying rheumatoid arthritis. The successful use of retinoids in the treatment of this proliferative but nonmalignant disorder demonstrates a new application of these compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinckerhoff, C E -- Coffey, J W -- Sullivan, A C -- AM14780/AM/NIADDK NIH HHS/ -- P60 AM20641/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):756-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthritis/*drug therapy ; Arthritis, Experimental/*drug therapy ; Female ; Fibrinogen/blood ; Inflammation/drug therapy ; Male ; Microbial Collagenase/biosynthesis ; Prostaglandins E/biosynthesis ; Rats ; Sex Factors ; Tretinoin/*therapeutic use
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Ventral posterior thalamic neurons differentially responsive to noxious stimulation of the awake monkey (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-12
    Description: Of 76 cutaneously activated neurons recorded from the ventral posterior thalamus of awake, behaving monkeys, nine were weakly excited by innocuous skin stimulation and responded maximally only when noxious mechanical cutaneous stimuli were delivered within small, contralateral receptive fields. These results show that neurons capable of encoding the spatial and temporal features of noxious stimuli are located in the ventral posterior thalamus of the awake primate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casey, K L -- Morrow, T J -- NS 12581/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):675-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Consciousness/physiology ; Electric Stimulation ; Neurons, Afferent/physiology ; Pain/*physiopathology ; Physical Stimulation ; Rats ; Saimiri ; Thalamic Nuclei/physiology ; Thalamus/cytology/*physiology
    Print ISSN: 0036-8075
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  • 9
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    Proglumide: selective antagonism of excitatory effects of cholecystokinin in central nervous system (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: Extracellular single-unit recording techniques were used to test the ability of proglumide to block cholecystokinin-induced excitation of rat midbrain dopaminergic neurons and dopamine-sensitive prefrontal cortex cells. Intravenous and iontophoretic proglumide administration consistently blocked cholecystokinin-induced excitations while having no effect on glutamic acid-induced increases in activity. This selective blockade of central cholecystokinin effects by proglumide suggests that this drug may be valuable for studying the possible role of cholecystokinin as a neurotransmitter or neuromodulator in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiodo, L A -- Bunney, B S -- MH-25642/MH/NIMH NIH HHS/ -- MH-28849/MH/NIMH NIH HHS/ -- NS-07136/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828873" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Cerebral Cortex/physiology ; Cholecystokinin/*pharmacology ; Drug Antagonism ; Glutamine/*analogs & derivatives ; Male ; Mesencephalon/physiology ; Neurons/drug effects/*physiology ; Proglumide/*pharmacology ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Gene splicers contemplate the rat brain (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):828-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6138857" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; DNA, Recombinant ; Gene Expression Regulation ; Nerve Tissue Proteins/*genetics ; Neurotransmitter Agents/*physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Brief deprivation of vision after unilateral lesions of the frontal eye field prevents contralateral inattention (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: Brief deprivation of vision after unilateral lesions of the frontal eye field prevents the appearance of contralateral inattention to visual, auditory, and somatosensory stimuli. The forced circling that accompanies inattention, however, is not affected. An equivalent preoperative period in the dark only partly reduces inattention symptoms. Visual deprivation does not reduce or prevent inattention resulting from lesions of the superior colliculus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crowne, D P -- Richardson, C M -- Ward, G -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):527-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836298" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attention/*physiology ; Darkness ; Frontal Lobe/*physiology ; Male ; Movement ; Rats ; Sensory Deprivation/*physiology ; Superior Colliculi/*physiology ; Visual Perception/*physiology
    Print ISSN: 0036-8075
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  • 12
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    Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: Mammalian atrial extracts possess natriuretic and diuretic activity. In experiments reported here it was found that atrial, but not ventricular, extract also causes relaxation of isolated vascular and nonvascular smooth muscle preparations. The smooth muscle relaxant activity of atrial extract was heat-stable and concentration-dependent and could be destroyed with protease. Rabbit aortic and chick rectum strips were used for the detection of atrial biological activity. The atrial activity was separated by column chromatography into two peaks having apparent molecular weights of 20,000 to 30,000 and less than 10,000. The atrial substance that copurified with the smooth muscle relaxant activity in both peaks caused natriuresis when injected into conscious rats. It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, M G -- Geller, D M -- Cole, B R -- Boylan, J G -- YuSheng, W -- Holmberg, S W -- Needleman, P -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Chickens ; Chromatography, Gel ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Molecular Weight ; Muscle, Smooth/drug effects ; Muscle, Smooth, Vascular/*drug effects ; Natriuresis/drug effects ; Rabbits ; Rats ; Swine ; Vasodilation/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    A polypeptide secreted by transformed cells that modulates human plasminogen activator production (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-08
    Description: A diffusible factor produced and secreted by malignant murine cells was capable of inducing plasminogen activator production by normal diploid human fibroblasts. The factor's ability to induce plasminogen activator was insensitive to treatment with nucleases, but its activity was destroyed by digestion with proteases. It is proposed that such a factor would play a role in malignancy if it would recruit normal cells that were adjacent to transformed cells to produce plasminogen activator which could result in tumor-promoted proteolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, R L -- Rifkin, D B -- Tepper, R -- Miller, A -- Kucherlapati, R -- CA-16239/CA/NCI NIH HHS/ -- CA-35171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Fibroblasts/drug effects/metabolism ; Humans ; Hybrid Cells/metabolism ; Melanoma/metabolism ; Mice ; Neoplasms, Experimental/*metabolism/secretion ; Peptides/pharmacology/*secretion ; Plasminogen Activators/*biosynthesis ; Rats
    Print ISSN: 0036-8075
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  • 14
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    Human cancer research (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dermer, G B -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):318.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; *Neoplasms ; Neoplasms, Experimental ; Rats ; Research
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  • 15
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    Collagen formation by the hepatocyte in primary monolayer culture and in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-18
    Description: Immunohistochemical techniques were used to confirm biochemical evidence that parenchymal cells isolated from adult rat liver and maintained in nonreplicating monolayer culture for 2 days synthesized type IV basement membrane collagen. On continued incubation in serum-free medium, the hepatocytes also synthesized the interstitial collagens, types I and III. Consistent with these results in culture, type IV collagen was localized to the hepatocytes in slices of pathologic rat liver. Hence collagen formation is a previously unrecognized function of the hepatocyte that may be important in the pathogenesis of liver fibrosis or cirrhosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diegelmann, R F -- Guzelian, P S -- Gay, R -- Gay, S -- AM18976/AM/NIADDK NIH HHS/ -- DE02570/DE/NIDCR NIH HHS/ -- HL11310/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1343-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828863" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basement Membrane/metabolism ; Cells, Cultured ; Collagen/*biosynthesis/immunology ; Liver/cytology/*metabolism ; Molecular Weight ; Rats
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  • 16
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    Transformation of Bloom's syndrome fibroblasts by DNA transfection (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-09
    Description: Nonmalignant diploid human fibroblast cells (GM3498B) derived from a skin biopsy of a patient with Bloom's syndrome have been transformed by transfection with DNA from a tumorigenic mouse cell line (Ha-8) carrying a single copy of the Harvey murine sarcoma virus (Ha-MuSV) genome. The transformed cell lines have an extended life-span, form colonies in agarose, and proliferate in nude mice--characteristics of neoplastic transformation. Like the parental cells, they also exhibit a high spontaneous level of sister chromatid exchanges. Finally, the transformed cells contain most, if not all, of the Ha-MuSV genome as well as the human rasH sequence. These experiments show that these diploid nonmalignant human cells can be used as recipients in transfection experiments for studying the genetic control of neoplastic transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doniger, J -- Di Paolo, J A -- Popescu, N C -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1144-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648529" target="_blank"〉PubMed〈/a〉
    Keywords: Bloom Syndrome/*genetics ; Cell Adhesion ; *Cell Transformation, Neoplastic ; Cells, Cultured ; DNA, Neoplasm/*genetics ; Humans ; Oncogenes ; Transfection
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  • 17
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    Direct in vivo monitoring of dopamine released from two striatal compartments in the rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-08
    Description: Microvoltammetric electrodes were used to monitor dopamine released in the caudate nucleus of the rat after electrical stimulation of the medial forebrain bundle. The time resolution of the technique is sufficient to determine in vivo concentration changes on a time scale of seconds. Direct evidence identifying the substance released as dopamine was obtained both voltammetrically and pharmacologically. Administration of alpha-methyl-p-tyrosine terminates the release of dopamine, although tissue stores of dopamine are still present. Thus there appears to be a compartment for dopamine storage that is not available for immediate release. This compartment appears to be mobilized by amfonelic acid, since administration of this agent after alpha-methyl-p-tyrosine returns the concentration of dopamine released by electrical stimulation to 75 percent of the original amount.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ewing, A G -- Bigelow, J C -- Wightman, R M -- KO 4 NS000356/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):169-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857277" target="_blank"〉PubMed〈/a〉
    Keywords: Amphetamine/pharmacology ; Animals ; Caudate Nucleus/drug effects/*metabolism ; Dopamine/*metabolism ; Male ; Methyltyrosines/pharmacology ; Microelectrodes ; Naphthyridines/pharmacology ; Rats ; Rats, Inbred Strains ; alpha-Methyltyrosine
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  • 18
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    Scientist sues over genetically impure mice (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
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  • 19
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    Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-18
    Description: Cerebral glucose metabolism in rats was examined 1 week after the production by ibotenic acid of unilateral striatal lesions. The incorporation of carbon-14-labeled deoxyglucose decreased within the lesion but much less than that of carbon-14-labeled glucose. Barbiturate anesthesia caused a reversal of the asymmetric striatal deoxyglucose labeling, such that the lesioned striatum retained more tracer than the contralateral side. The combined use of barbiturates and radiolabeled deoxyglucose may enhance the identification of recent brain infarction in experimental animals and in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frey, K A -- Agranoff, B W -- 1 T32 GM07863/GM/NIGMS NIH HHS/ -- NS 15655/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):879-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Barbiturates/*pharmacology ; Brain/*drug effects/metabolism ; Brain Diseases/chemically induced/metabolism ; Corpus Striatum/drug effects ; Deoxyglucose ; Glucose/metabolism ; Ibotenic Acid ; Rats
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  • 20
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    Light and propranolol suppress the nocturnal elevation of serotonin in the cerebrospinal fluid of rhesus monkeys (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-29
    Description: Markedly elevated nighttime concentrations of serotonin in rhesus monkey cerebrospinal fluid were reduced to daytime levels by exposing the monkeys to continuous light or to the beta-adrenergic antagonist propranolol. Nighttime elevations of melatonin in cerebrospinal fluid were also suppressed by propranolol and light. Serotonin released in large quantities at night appears to be regulated like melatonin, and may act as a cerebroventricular hormone to influence brain and pituitary function at night.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garrick, N A -- Tamarkin, L -- Taylor, P L -- Markey, S P -- Murphy, D L -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):474-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6683428" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Circadian Rhythm/drug effects ; Humans ; *Light ; Macaca mulatta ; Male ; Melatonin/physiology ; Propranolol/*pharmacology ; Rats ; Serotonin/*cerebrospinal fluid/physiology
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  • 21
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    Mutagenicity of glutathione and cysteine in the Ames test (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-27
    Description: Postmitochondrial supernatant from rat liver and kidney homogenates transformed cysteine into a mutagen that reverted bacteria of the strain Salmonella typhimurium TA100 to histidine independence. Glutathione was also activated by kidney postmitochondrial supernatant but not by liver preparations. Hence, important endogenous compounds of mammals are positive in the most commonly used short-term test for carcinogenicity and mutagenicity. Glutathione is positive in the test even at concentrations found in mammalian tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glatt, H -- Protic-SabljiC, M -- Oesch, F -- New York, N.Y. -- Science. 1983 May 27;220(4600):961-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6342137" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cysteine/*pharmacology ; Glutathione/*pharmacology ; Histidine/metabolism ; Hydrogen Peroxide/metabolism ; Kidney/metabolism ; Liver/metabolism ; *Mutagenicity Tests ; Mutagens/*pharmacology ; Rats ; Salmonella typhimurium/metabolism
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  • 22
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    Cortical dopaminergic involvement in cocaine reinforcement (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-19
    Description: Neuronal systems involved in the initiation of cocaine reinforcement were investigated by identifying brain sites where direct application of the drug was reinforcing. This was accomplished by allowing rats to self-administer picomolar concentrations of cocaine into discrete brain regions. The medial prefrontal cortex supported self-administration, while the nucleus accumbens and ventral tegmental area did not. Self-administration could be attenuated by including equimolar concentrations of the dopaminergic D2-receptor antagonist sulpiride in the microinjection system. These results imply that cocaine reinforcement is mediated in part through a direct action on mesocortical dopaminergic receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goeders, N E -- Smith, J E -- DA-01999-04/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):773-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Cerebral Cortex/*drug effects/physiology ; Cocaine/*pharmacology ; Dopamine/*physiology ; Male ; Nucleus Accumbens/physiology ; Rats ; Self Administration ; Sulpiride/pharmacology
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  • 23
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    Cocaine-induced rotation: sex-dependent differences between left- and right-sided rats (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-19
    Description: Cocaine elicited dose-related rotation (circling) in naive rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results suggest that sex-dependent differences in brain asymmetry may be an important determinant of cocaine sensitivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glick, S D -- Hinds, P A -- Shapiro, R M -- DA 01044/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cocaine/*pharmacology ; Dextroamphetamine/pharmacology ; Female ; Functional Laterality ; Male ; Movement/*drug effects ; Rats ; Rotation ; Sex Factors
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  • 24
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    Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R R -- Kuhar, M J -- Hester, L -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 27;220(4600):967-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302841" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*physiology ; Animals ; Autoradiography ; Axons/*physiology ; Cerebellum/physiology ; Corpus Striatum/physiology ; Hippocampus/physiology ; Mice ; Mice, Neurologic Mutants ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*physiology ; Receptors, Purinergic ; Retinal Ganglion Cells/physiology ; Synaptic Membranes/physiology ; Thalamus/physiology
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  • 25
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    Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-08
    Description: Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused the formation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grafstrom, R C -- Fornace, A J Jr -- Autrup, H -- Lechner, J F -- Harris, C C -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828890" target="_blank"〉PubMed〈/a〉
    Keywords: Bronchi/*cytology/drug effects ; Cells, Cultured ; *DNA/biosynthesis ; DNA Repair/*drug effects ; Epithelium/drug effects ; Fibroblasts/drug effects ; Formaldehyde/*pharmacology ; Humans
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    Expression of a cellular oncogene during liver regeneration (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-02-04
    Description: The number of transcripts of the cellular oncogene ras, which is homologous to the transforming gene of Harvey sarcoma virus, increases during liver regeneration in rats. The increase in these transcripts in liver polysomal polyadenylated RNA occurs at the time of activation of DNA synthesis during the regenerative process induced by partial hepatectomy or carbon tetrachloride injury. The number of ras transcripts returns to basal levels within 72 hours. These observations show that transcription of a cellular oncogene increases in a regulated way in a nonneoplastic growth process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goyette, M -- Petropoulos, C J -- Shank, P R -- Fausto, N -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):510-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Tetrachloride Poisoning ; DNA/biosynthesis ; Hepatectomy ; *Liver Regeneration ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/biosynthesis ; Rats ; Sarcoma Viruses, Murine/genetics ; Time Factors ; *Transcription, Genetic
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  • 27
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    Neuron-glia adhesion is inhibited by antibodies to neural determinants (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-07
    Description: Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grumet, M -- Rutishauser, U -- Edelman, G M -- AI-11378/AI/NIAID NIH HHS/ -- HD-09635/HD/NICHD NIH HHS/ -- HD-16550/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):60-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6194561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal ; Antigen-Antibody Complex ; *Cell Adhesion ; Cell Membrane/immunology ; Cells, Cultured ; Chick Embryo ; Epitopes ; Immunoglobulin Fab Fragments ; Neuroglia/*physiology ; Neurons/immunology/*physiology
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  • 28
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    An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-16
    Description: In vitro binding studies have demonstrated the existence of multiple opiate receptor types. An additional site in the rat brain (termed the lambda site) is distinct from the established types by its selectivity for 4,5-epoxymorphinans (such as naloxone and morphine). While the lambda site displays a high affinity for naloxone in vivo and in vitro in fresh brain membrane homogenates, these sites rapidly convert in vitro to a state of low affinity. The regional distribution of the lambda site in the brain is strikingly different from that of the classic opiate receptor types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grevel, J -- Sadee, W -- AG 031047/AG/NIA NIH HHS/ -- DA 01095/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1198-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310750" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain Chemistry ; Dihydromorphine/metabolism ; Diprenorphine/metabolism ; Morphine/metabolism ; Nalorphine/metabolism ; Naloxone/*metabolism ; Naltrexone/metabolism ; Rats ; Receptors, Opioid/*metabolism ; Sodium/metabolism ; Tissue Distribution
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    Midbrain microinfusions of prolactin increase the estrogen-dependent behavior, lordosis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Microinfusions of rat prolactin into the dorsal midbrain of estrogen-treated, ovariectomized rats increased lordosis behavior. Midbrain microinfusions of antiserum to prolactin into rats displaying maximum lordosis had the opposite effect. The distribution of a prolactin-like substance in the brain was studied immunocytochemically. The results suggest that a hypothalamic neuronal system projecting to the midbrain contains a prolactin-like substance that plays a role in facilitating this behavior and therefore may mediate some of the effects of estrogen on the brain. These data, together with others from studies of the prolactin gene and its regulation, indicate that it may be possible to analyze a sequence of molecular events in the brain that facilitate a behavioral response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harlan, R E -- Shivers, B D -- Pfaff, D W -- HD-05585/HD/NICHD NIH HHS/ -- HD-05737/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828874" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Castration ; Cerebral Cortex/drug effects/*physiology ; Cosyntropin/pharmacology ; Estradiol/pharmacology ; Female ; Growth Hormone/pharmacology ; Immune Sera ; Kinetics ; Mesencephalon/*physiology ; Oxytocin/pharmacology ; Posture ; Prolactin/administration & dosage/*pharmacology ; Rats ; Sexual Behavior, Animal/*drug effects ; Vasopressins/pharmacology
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    Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibody-producing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-specific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas other recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haspel, M V -- Onodera, T -- Prabhakar, B S -- Horita, M -- Suzuki, H -- Notkins, A L -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301002" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology/*microbiology ; Endocrine Glands/*immunology ; Enzyme-Linked Immunosorbent Assay ; Growth Hormone/immunology ; Humans ; Hybridomas/immunology ; Mice ; Pituitary Gland, Anterior/immunology ; Rats ; Reoviridae Infections/*immunology
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    Contiguity to males in utero affects avoidance responding in adult female mice (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-22
    Description: Female mice that had been situated in utero between two female fetuses displayed higher levels of active avoidance responding in adult life than females that had been located between two male fetuses and males for whom uterine position was without effect. Uterine position, therefore, influences acquired as well as species-typical behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hauser, H -- Gandelman, R -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836288" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/physiology ; Animals ; Avoidance Learning/*physiology ; Female ; Fetus/*physiology ; Male ; Mice ; Pregnancy ; Rats ; Sex Factors ; Uterus
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    In vivo one-dimensional imaging of phosphorus metabolites by phosphorus-31 nuclear magnetic resonance (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: A phosphorus-31 nuclear magnetic resonance imaging technique has been used to obtain information on phosphorus metabolites from different spatial regions of tissues in vivo. The technique for selection of planes through the tissue is based on phase-encoding of spin echoes and was used to obtain one-dimensional discrimination of phosphorus-31 spectra from different parts of the tissue simultaneously. Specimens were resolved into 16 distinct slices and a signal-to-noise ratio of about 20 to 1 was obtained in 1/2 hour. Results are presented for phantoms, rat legs, and gerbil heads.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haselgrove, J C -- Subramanian, V H -- Leigh, J S Jr -- Gyulai, L -- Chance, B -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1170-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857240" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Gerbillinae ; Magnetic Resonance Spectroscopy/*methods ; Phosphocreatine/metabolism ; Phosphoric Acids/metabolism ; Phosphorus/*metabolism ; Rats
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  • 33
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    Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: Long-term treatment of rats with atropine induced large increases in the numbers of muscarinic receptors and receptors for vasoactive intestinal polypeptide in the salivary glands. Since receptors for vasoactive intestinal polypeptide coexist with muscarinic receptors on the same neurons in this preparation, the results suggest that a drug that alters the sensitivity of one receptor may also affect the sensitivity of the receptor for a costored transmitter and in this way contribute to the therapeutic or side effects of the drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedlund, B -- Abens, J -- Bartfai, T -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):519-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132446" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/*pharmacology ; Gastrointestinal Hormones/*metabolism ; Male ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*drug effects ; Receptors, Muscarinic/analysis/*drug effects ; Salivary Glands/analysis/innervation ; Vasoactive Intestinal Peptide/analysis/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Lines of T lymphocytes induce or vaccinate against autoimmune arthritis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-07
    Description: The pathophysiology of autoimmune arthritis was studied by selecting and isolating lines of effector T lymphocytes from rats administered an arthritogenic dose of Mycobacterium tuberculosis in complete Freund's adjuvant to induce adjuvant arthritis. Irradiated rats were intravenously inoculated with a cell line characterized by proliferative reactivity to Mycobacterium tuberculosis and, to a lesser degree, to rat collagen type II. This produced arthritis in all the irradiated rats. Nonirradiated recipients failed to develop arthritis. However, such rats, and those recovering from cell-mediated arthritis, were resistant to subsequent attempts to induce adjuvant arthritis. Lines of T lymphocytes selected for responsiveness to other antigens had no effect. Therefore, a line of T lymphocytes responsive to bacteria or to collagen type II could either induce autoimmune arthritis or serve as an agent of vaccination against it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holoshitz, J -- Naparstek, Y -- Ben-Nun, A -- Cohen, I R -- NS 18168/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):56-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6336851" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthritis/*etiology ; Arthritis, Experimental/etiology ; Autoimmune Diseases/*etiology ; Collagen/immunology ; Lymphocyte Activation ; Rats ; T-Lymphocytes/*immunology ; Vaccination ; Whole-Body Irradiation
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    Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Honchar, M P -- Olney, J W -- Sherman, W R -- MH-14677/MH/NIMH NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- NS-05159/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301005" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/pharmacology ; Brain Chemistry/drug effects ; Chlorides/adverse effects ; Drug Interactions ; Humans ; Inositol/analogs & derivatives/analysis ; *Inositol Phosphates ; Lithium/*adverse effects ; Lithium Chloride ; Male ; Parasympathomimetics/*adverse effects ; Physostigmine/adverse effects ; Pilocarpine/adverse effects ; Rats ; Rats, Inbred Strains ; Seizures/*chemically induced ; Substance-Related Disorders/*etiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    A parathyroid hormone inhibitor in vivo: design and biological evaluation of a hormone analog (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-03
    Description: A synthetic analog of bovine parathyroid hormone (bPTH), [tyrosine-34] bPTH-(7-34)NH2, was found to inhibit parathyroid hormone action in vivo. When the analog and parathyroid hormone were infused simultaneously to rats at a molar ratio of 200 to 1, the analog inhibited the excretion of urinary phosphate and adenosine 3',5'-monophosphate. When infused alone at the same dose rate, the analog was devoid of agonist activity. The compound was prepared by following design principles developed for inhibitors of parathyroid hormone, and is believed to be the first antagonist of parathyroid hormone that is effective in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horiuchi, N -- Holick, M F -- Potts, J T Jr -- Rosenblatt, M -- AM11749/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1053-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302844" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cyclic AMP/urine ; Dose-Response Relationship, Drug ; Male ; Parathyroid Hormone/*antagonists & inhibitors/*pharmacology ; Peptide Fragments/*pharmacology ; Phosphates/urine ; Rats
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    Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-22
    Description: Depletion of polyamines in 9L rat brain tumor cells by treatment with alpha-difluoromethylornithine dramatically altered DNA conformation as measured by viscoelastometry. The reduction of intracellular putrescine and spermidine concentrations to less than 5 percent of their concentrations in control cells decreased the sensitivity of 9L cell DNA to x-irradiation and increased the maximum viscoelastic retardation time of the DNA. Both of these phenomena were reversed by addition of exogenous putrescine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hung, D T -- Marton, L J -- Deen, D F -- Shafer, R H -- CA-13525/CA/NCI NIH HHS/ -- CA-19658/CA/NCI NIH HHS/ -- CA-27343/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):368-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Neoplasms/*metabolism ; DNA, Neoplasm/*metabolism ; Eflornithine ; Molecular Conformation ; Ornithine/analogs & derivatives/pharmacology ; Polyamines/*metabolism ; Putrescine/metabolism ; Rats ; Spermidine/metabolism ; Viscosity
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  • 38
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    Protein phosphatases: properties and role in cellular regulation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-22
    Description: Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingebritsen, T S -- Cohen, P -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):331-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cyclic AMP/metabolism ; Glycogen/metabolism ; Liver/enzymology ; Muscles/enzymology ; Phosphoprotein Phosphatases/classification/*physiology ; Phosphoproteins/metabolism ; Phosphorylase Phosphatase/metabolism ; Phosphorylation ; Protein Biosynthesis ; Protein Kinases/physiology ; Rabbits ; Rats
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  • 39
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    Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-23
    Description: Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbing factor with the chemical characteristics of a tumor-derived transforming growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ibbotson, K J -- D'Souza, S M -- Ng, K W -- Osborne, C K -- Niall, M -- Martin, T J -- Mundy, G R -- AM-28149/AM/NIADDK NIH HHS/ -- CA-29537/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1292-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6577602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Resorption ; Calcium ; Cells, Cultured ; Culture Media ; Growth Substances/*physiology ; Hypercalcemia/*etiology ; Leydig Cell Tumor/complications/*physiopathology ; Male ; Neoplasm Proteins/*physiology ; Neoplasms, Experimental/complications/physiopathology ; Peptides/*physiology ; Rats ; Transforming Growth Factors
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  • 40
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    Fragile sites in chromosomes: possible model for the study of spontaneous chromosome breakage (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-01
    Description: The tissue culture condition that is required for the type of chromosome breakage seen at most fragile sites, namely, the absence of folic acid and thymidine in the medium, greatly enhanced micronucleus formation in proliferating lymphocyte cultures from normal individuals. This suggests that chromosome breakage at fragile sites and the apparently spontaneous damage that gives rise to micronuclei are controlled by the same mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacky, P B -- Beek, B -- Sutherland, G R -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):69-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828880" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Cell Nucleus/drug effects/ultrastructure ; Cells, Cultured ; Child ; *Chromosome Aberrations ; Chromosome Fragile Sites ; *Chromosome Fragility ; Culture Media ; Dose-Response Relationship, Drug ; Female ; Folic Acid/pharmacology ; Humans ; Lymphocytes/ultrastructure ; Male ; Middle Aged ; Thymidine/pharmacology
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    Some neurons of the rat central nervous system contain aromatic-L-amino-acid decarboxylase but not monoamines (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-11
    Description: Neurons containing the enzyme aromatic-L-amino-acid decarboxylase (AADC) but lacking either tyrosine hydroxylase or serotonin were found in the spinal cord of neonatal and adult rats by light and electron microscopic immunocytochemistry. The majority of these neurons localized to area X of Rexed contact ependyma. Thus, spinal AADC neurons have the enzymatic capacity to catalyze directly the conversion of the amino acids tyrosine, tryptophan, or phenylalanine to their respective amines tyramine, tryptamine, or phenylethylamine. These amines normally present in the central nervous system may be of potential clinical significance as endogenous psychotomimetics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaeger, C B -- Teitelman, G -- Joh, T H -- Albert, V R -- Park, D H -- Reis, D J -- HL-07379-04/HL/NHLBI NIH HHS/ -- HL-18974/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 11;219(4589):1233-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6131537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aromatic-L-Amino-Acid Decarboxylases/*metabolism ; Biogenic Amines/*metabolism ; Brain/*metabolism ; Neurons/enzymology ; Neurotransmitter Agents/biosynthesis ; Rats ; Spinal Cord/*metabolism
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  • 42
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    Intermolecular interactions in collagen self-assembly as revealed by Fourier transform infrared spectroscopy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-17
    Description: When a solution of collagen molecules, at neutral pH and moderate ionic strength, is warmed from 4 degrees to 30 degrees C, a spontaneous self-assembly process takes place in which native-type collagen fibers are produced. Events occurring during thermally induced fibrillogenesis process can be monitored, in aqueous media and in real time, by Fourier transform infrared spectroscopic techniques. Tentative assignments of observed spectral bands are given.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jakobsen, R J -- Brown, L L -- Hutson, T B -- Fink, D J -- Veis, A -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857249" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Collagen/*metabolism ; Connective Tissue/metabolism ; Rats ; Spectrophotometry, Infrared ; Temperature
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  • 43
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    Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-26
    Description: Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharin solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharin intake may cause increased release and utilization of endogenous opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lieblich, I -- Cohen, E -- Ganchrow, J R -- Blass, E M -- Bergmann, F -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):871-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879185" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drug Tolerance ; Endorphins/physiology ; Morphine/*pharmacology ; Pain/physiopathology ; Rats ; Saccharin/*pharmacology ; Stress, Physiological/*physiopathology
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  • 44
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    Role of surface-active phospholipids in gastric cytoprotection (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-18
    Description: Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lichtenberger, L M -- Graziani, L A -- Dial, E J -- Butler, B D -- Hills, B A -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1327-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828859" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Mucosa/*physiology ; Indomethacin/pharmacology ; Phospholipids/*physiology ; Prostaglandins/physiology ; Rats ; Stomach Ulcer/physiopathology ; Surface-Active Agents
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    Synthesizing the opioid peptides (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):395-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836282" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/physiology ; Endorphins/*biosynthesis/genetics ; Humans ; Mice ; Nervous System Physiological Phenomena ; Pituitary Hormones, Anterior/biosynthesis/genetics ; Pro-Opiomelanocortin ; Protein Precursors/biosynthesis/genetics ; RNA, Messenger/metabolism ; Rats
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  • 46
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    A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-28
    Description: The benzodiazepine receptor antagonist 3-hydroxymethyl-beta-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-beta-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mendelson, W B -- Cain, M -- Cook, J M -- Paul, S M -- Skolnick, P -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):414-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6294835" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbolines/*pharmacology ; Flurazepam/*antagonists & inhibitors ; Indoles/*pharmacology ; Male ; Rats ; Receptors, Cell Surface/*drug effects ; Receptors, GABA-A ; Sleep/*drug effects ; Wakefulness/drug effects
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  • 47
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    Potential role of galactokinase in neonatal carbohydrate assimilation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Glucose given to the newborn human may result in hyperglycemia, suggesting that its utilization is impaired at this developmental stage. Galactose is thought to be a more appropriate carbohydrate source for the newborn. The enzymes involved in hexose phosphorylation may, in part, be responsible for these observations. A key regulatory enzyme of hepatic glucose assimilation, glucokinase, is diminished in newborns compared to adults, whereas galactokinase activity is increased. When newborn dogs were fasted and then fed either glucose or galactose, their plasma insulin responses to glucose were similar, but the pups fed galactose demonstrated an attenuated systemic appearance rate of glucose. Hexose incorporation into hepatic glycogen and net glycogen synthesis was augmented in the galactose-fed dogs. In vitro, liver from neonatal dogs showed enhanced galactokinase activity relative to that for hexokinase or glucokinase. Neonatal hexose assimilation may be independent of insulin action and, instead, be related to the developmental presence of hexose phosphorylating enzymes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kliegman, R M -- Miettinen, E L -- Morton, S -- HD05740/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):302-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836273" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Animals, Newborn/metabolism ; *Carbohydrate Metabolism ; Dogs ; Galactokinase/*physiology ; Galactose/metabolism ; Galactosemias ; Glucose/metabolism ; Humans ; Infant, Newborn ; Liver/enzymology ; Liver Glycogen/biosynthesis ; Phosphorylation ; Rats
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  • 48
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    Oxygen tension regulates the expression of angiogenesis factor by macrophages (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-23
    Description: When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those of well-oxygenated tissue, macrophages did not secrete active angiogenesis factor. Macrophages that secreted the factor at hypoxic conditions stopped secreting it when returned to room air. Thus the control of angiogenesis in wound healing may be the result of macrophages responding to tissue oxygen tension without the necessity of interacting with other cell types or biochemical signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knighton, D R -- Hunt, T K -- Scheuenstuhl, H -- Halliday, B J -- Werb, Z -- Banda, M J -- GM27345/GM/NIGMS NIH HHS/ -- HL26323/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612342" target="_blank"〉PubMed〈/a〉
    Keywords: Angiogenesis Inducing Agents/*biosynthesis ; Animals ; Anoxia/physiopathology ; Cells, Cultured ; Cornea ; Growth Substances/*biosynthesis ; Macrophages/*physiology ; Models, Biological ; Oxygen/*physiology ; Rabbits ; *Wound Healing
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  • 49
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    Drug-induced alterations of cytokeratin organization in cultured epithelial cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-04
    Description: The distribution of keratin intermediate filaments, previously considered static in organization and imperturbable by conventional drugs used to alter the structure and organization of the cytoskeleton, can be altered significantly by treatment with colchicine and cytochalasin D. The loss of microfilaments and microtubules converts the keratin cytoskeleton from a branching, even distribution to a series of starlike structures whose filaments are maintained by multiple membrane attachment sites. These findings provide a means for manipulating cytokeratin organization to investigate the role of keratins in cytoskeletal structure and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knapp, L W -- O'Guin, W M -- Sawyer, R H -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):501-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186022" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Colchicine/*pharmacology ; Cytochalasin D ; Cytochalasins/*pharmacology ; Cytoskeleton/*drug effects ; Epithelium ; *Keratins ; Mice ; Microtubules/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Passive transfer of diabetes in the BB/W rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: Severe diabetes with insulitis was produced in young diabetes-prone BB/W rats by passive transfer of concanavalin A-treated spleen cells from BB/W animals with acute diabetes. Spleen cells alone or in combination with lymph node cells were active in transferring disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koevary, S -- Rossini, A -- Stoller, W -- Chick, W -- Williams, R M -- AM-25306/AM/NIADDK NIH HHS/ -- AM-30846/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):727-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836309" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Concanavalin A/pharmacology ; Diabetes Mellitus/etiology/*immunology ; Hyperglycemia/etiology/immunology ; Immunity, Cellular ; Mice ; Mice, Nude ; Rats ; Spleen/cytology/drug effects/transplantation ; Transplantation, Heterologous ; Transplantation, Homologous
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    Brain-grafting work shows promise (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1277.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612340" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/surgery ; Animals ; Humans ; Memory/physiology ; Nerve Tissue/*transplantation ; Parkinson Disease/*surgery ; Rats
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    Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-25
    Description: Intracisternal injection of ovine corticotropin-releasing factor (CRF) into the pylorus-ligated rat or the rat with gastric fistula resulted in a dose-dependent inhibition of gastric secretion stimulated with pentagastrin or thyrotropin-releasing hormone. When injected into the lateral hypothalamus--but not when injected into the cerebral cortex--CRF suppressed pentagastrin-stimulated acid secretion. The inhibitory effect of CRF was blocked by vagotomy and adrenalectomy but not by hypophysectomy or naloxone treatment. These results indicate that CRF acts within the brain to inhibit gastric acid secretion through vagal and adrenal mechanisms and not through hypophysiotropic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tache, Y -- Goto, Y -- Gunion, M W -- Vale, W -- River, J -- Brown, M -- AM30110/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):935-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6415815" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Brain/*drug effects ; Cerebral Cortex/drug effects ; Corticotropin-Releasing Hormone/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Gastric Acid/*secretion ; Hypophysectomy ; Hypothalamus/drug effects ; Male ; Pentagastrin/antagonists & inhibitors ; Rats ; Rats, Inbred Strains ; Thyrotropin-Releasing Hormone/antagonists & inhibitors ; Vagotomy
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    Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-01
    Description: Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tannenbaum, G S -- Guyda, H J -- Posner, B I -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Weight/*drug effects ; Brain/drug effects/*physiology ; Eating/drug effects ; Growth Hormone/antagonists & inhibitors/blood/*physiology ; Insulin/blood/*pharmacology ; Male ; Peptides/*pharmacology ; Rats ; Rats, Inbred Strains ; Somatomedins/*pharmacology
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    Genetically obese mice: resistance to metastasis of B16 melanoma and enhanced T-lymphocyte mitogenic responses (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: The metastasis of B16 melanoma cells differed significantly in obese (ob/ob) and lean (+/?) female mice of strain C57BL/6J. When the mice were inoculated subcutaneously with melanoma cells at 10 to 11 months of age, the primary tumor grew more slowly in obese than in lean littermates and the frequency of lung metastasis was greatly reduced. When the mice were injected with the cells at 4 to 7 months, the primary tumor grew at the same rate in obese and lean mice, but the obese mice again showed a significantly reduced frequency of lung metastasis. That this effect was related to an enhanced immunocompetence in obese mice was supported by the finding that splenic lymphocytes of ob/ob mice showed three times the proliferative response to the T-cell mitogen concanavalin A compared with the proliferative response of lean control mice. The ob/ob mouse may provide a model for the study of enhanced immunocompetence in obese individuals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, C I -- Kreider, J W -- Black, P L -- Schmidt, T J -- Margules, D L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602379" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Immunity, Innate ; Lung Neoplasms/immunology ; Male ; Melanoma/*immunology ; Mice ; Mice, Inbred C57BL ; *Mice, Obese ; Neoplasm Metastasis ; Neoplasm Transplantation ; Neoplasms, Experimental/immunology ; Rats ; Receptors, Glucocorticoid/physiology ; T-Lymphocytes/*physiology
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    Human endothelial cells: use of heparin in cloning and long-term serial cultivation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-11-11
    Description: Endothelial cells from human blood vessels were cultured in vitro, with doubling times of 17 to 21 hours for 42 to 79 population doublings. Cloned human endothelial cell strains were established for the first time and had similar proliferative capacities. This vigorous cell growth was achieved by addition of heparin to culture medium containing reduced concentrations of endothelial cell growth factor. The routine cloning and long-term culture of human endothelial cells will facilitate studying the human endothelium in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornton, S C -- Mueller, S N -- Levine, E M -- AG-00839/AG/NIA NIH HHS/ -- T32-CA-09171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):623-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635659" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cells, Cultured ; Clone Cells/enzymology ; Endothelium/*cytology ; Growth Substances/pharmacology ; Heparin/*pharmacology ; Humans ; Time Factors
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    Interaction with membrane remnants of target myotubes maintains transmitter sensitivity of cultured neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Parasympathetic neurons, when cultured alone, lose sensitivity to acetylcholine, but if striated muscle is included in the culture, neuronal chemosensitivity is maintained. The membrane remnants of myotubes ruptured by osmotic shock also supported the responsiveness of the cultured neurons to transmitter, whereas muscle-conditioned medium or membrane remnants of nonmuscle embryonic skin cells did not support this responsiveness. The regulation of chemosensitivity by contact of neurons with the target cell membrane may be important in the formation and maintenance of neuronal circuitry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tuttle, J B -- NS-10338/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):977-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6133352" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Animals ; Cell Membrane/physiology ; Cells, Cultured ; Chick Embryo ; Fibroblasts/physiology ; Muscles/*physiology ; Nervous System/growth & development ; Neurons/*physiology ; Neurotransmitter Agents/*physiology ; Synapses/physiology
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    Bone cell differentiation and growth factors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-13
    Description: Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Urist, M R -- DeLange, R J -- Finerman, G A -- DEO2103-17/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):680-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403986" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Development ; Bone Matrix/drug effects/physiology ; Bone Morphogenetic Proteins ; Bone Neoplasms/physiopathology ; Cattle ; Cell Differentiation ; DNA, Neoplasm/metabolism ; Dogs ; Growth Substances/*physiology ; Guinea Pigs ; Haplorhini ; Humans ; Insulin-Like Growth Factor II ; Mice ; *Osteogenesis ; Osteosarcoma/physiopathology ; Proteins/pharmacology/physiology ; Rabbits ; Rats
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    Potent interaction between glucocorticoids and growth hormone-releasing factor in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-05
    Description: Administration of dexamethasone significantly enhanced the pituitary growth hormone response to growth hormone-releasing factor in intact as well as adrenalectomized rats. Thus the inhibitory effects of glucocorticosteroids on somatic growth which involve an interaction of these steroids and growth hormone at a peripheral level may also involve a modification of pathways within the central nervous system that regulate normal growth hormone secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehrenberg, W B -- Baird, A -- Ling, N -- AM-18811/AM/NIADDK NIH HHS/ -- HD 09690/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):556-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408735" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Dexamethasone/pharmacology ; Drug Interactions ; Glucocorticoids/*pharmacology ; Growth Hormone/blood/secretion ; Growth Hormone-Releasing Hormone/*pharmacology ; Male ; Rats ; Rats, Inbred Strains
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    High-frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-10-28
    Description: A protoplast fusion method was developed to stably transfect human cells with pSV2-derived plasmids at frequencies greater than 10(-3). This procedure made it possible to test the biological effect of a hepatitis B virus (HBV) gene independent of the viral structures required for infection. A pSV2gpt+ plasmid constructed to carry a subgenomic fragment of HBV that contained the core antigen gene (HBc gene) was transfected into human cells. A human epithelial cell line was stably transfected with the HBc+ gene by selecting recipient cells for expression of guanine phosphoribosyl transferase expression. With this gpt+/HBc+ cell line it was shown that growth in serum-free medium or treatment with 5'-azacytidine stimulates the production of the HBV core antigen. A hepatocellular carcinoma carrying the entire HBV genome was stimulated to produce the HBc gene product in response to the same factors that stimulated HBcAg production in the gpt+/HBc+ cell line constructed by transfection. The temporal relation between the cytopathologic response and HBc gene expression was similar for both cell types, indicating a primary role for HBc gene expression in the cytopathology of HBV-infected human liver.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoakum, G H -- Korba, B E -- Lechner, J F -- Tokiwa, T -- Gazdar, A F -- Seeley, T -- Siegel, M -- Leeman, L -- Autrup, H -- Harris, C C -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):385-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6194563" target="_blank"〉PubMed〈/a〉
    Keywords: Azacitidine/pharmacology ; Cell Fusion ; *Cell Transformation, Viral ; Cells, Cultured ; Cytopathogenic Effect, Viral ; Gene Expression Regulation/drug effects ; Genes, Viral ; Hepatitis B Core Antigens/*genetics ; Humans ; Transfection
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    Salicylate and mitochondrial injury in Reye's syndrome (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-08
    Description: Electron microscopic and spectrophotometric studies showed that salicylate causes gross swelling of mitochondria in isotonic salt solutions. In overall morphology the salicylate-treated mitochondria resembled those from patients with Reye's syndrome. Salicylate analogs such as m-hydroxybenzoate, p-hydroxybenzoate, and benzoate did not exert this effect. The mitochondria deformed by salicylate tended to return to their original condensed form on removal of the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉You, K -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):163-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857275" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzoates/pharmacology ; Benzoic Acid ; Hydroxybenzoates/pharmacology ; Microscopy, Electron ; Mitochondria, Liver/*drug effects/ultrastructure ; Mitochondrial Swelling/drug effects ; *Parabens ; Rats ; Reye Syndrome/*chemically induced ; Salicylates/*adverse effects/pharmacology
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    Increased brain size and cellular content in infant rats treated with an opiate antagonist (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-16
    Description: From birth to day 21, rat offspring received daily injections of naltrexone at a dosage that blocked morphine-induced analgesia 24 hours a day. At 21 days, body, brain, and cerebellar weights of naltrexone-injected animals were 18, 11, and 5 percent greater than corresponding control weights. In addition, morphometric analysis of the cerebrum revealed a somatosensory cortex that was 18 percent thicker than that of the controls. The cerebellum of naltrexone-treated rats was 41 percent larger in total area and contained at least 70 percent more glial cells and 30 percent more granule neurons. Neurons derived prenatally were unaffected by drug treatment. These results show that naltrexone can stimulate body and brain growth in rats and suggest a role for the endorphin and opiate receptor system in development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zagon, I S -- McLaughlin, P J -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1179-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612331" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Body Weight/drug effects ; Brain/*drug effects/growth & development/ultrastructure ; Cerebellum/drug effects ; Morphine/*antagonists & inhibitors ; Naloxone/*analogs & derivatives ; Naltrexone/*pharmacology ; Neuroglia/drug effects ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; Somatosensory Cortex/drug effects
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    Insulin receptor: evidence that it is a protein kinase (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-21
    Description: Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor. This subunit of the insulin receptor was also labeled with [alpha-32P]8-azidoadenosine 5'-triphosphate, a photoaffinity label for adenosine triphosphate binding sites. The identity of the 95,000-dalton band was confirmed in both cases by precipitation with a monoclonal antibody to the insulin receptor. These results suggest that the insulin receptor is itself a protein kinase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, R A -- Cassell, D J -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849137" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Cell Line ; Cells, Cultured ; Lymphocytes ; Molecular Weight ; Phosphoproteins/physiology ; Protein Kinases/*physiology ; Receptor, Insulin/*physiology
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    Interrelated striated elements in vestibular hair cells of the rat (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Unusual fixation procedures revealed a series of interrelated striated organelles in type I and type II vestibular hair cells of the rat; these organelles seemed to be less well developed in cochlear hair cells. The findings suggest that contractile elements may play a role in sensory transduction in the inner ear, particularly in the vestibular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, M D -- Bourne, C -- New York, N.Y. -- Science. 1983 May 6;220(4597):622-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682246" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/physiology ; Animals ; Cell Membrane/ultrastructure ; Cytoskeleton/ultrastructure ; Hair Cells, Auditory/*ultrastructure ; Microscopy, Electron ; Organoids/ultrastructure ; Rats ; Rats, Inbred Strains
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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    Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-21
    Description: A current hypothesis links the neuroexcitatory properties of certain acidic amino acids to their ability to cause selective neuronal lesions. Intracerebral injection of the neuroexcitatory tryptophan metabolite, quinolinic acid, has behavioral, neurochemical, and neuropathological consequences reminiscent of those of exogenous excitotoxins, such as kainic and ibotenic acids. Its qualities as a neurotoxic agent suggest that quinolinic acid should be considered as a possible pathogenic factor in neurodegenerative disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarcz, R -- Whetsell, W O Jr -- Mangano, R M -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):316-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849138" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/drug effects ; Brain/*drug effects/enzymology ; Corpus Striatum/drug effects/enzymology/ultrastructure ; Hippocampus/drug effects ; Neuroglia/drug effects ; Neurons/drug effects ; Pyridines/*pharmacology ; Quinolinic Acids/*pharmacology ; Rats
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    Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-08
    Description: Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase inhibitor diisopropyl fluorophosphate, binding of tritiated acetylcholine in the cerebral cortex was decreased. However, after repeated administration of nicotine for 10 days, binding of tritiated acetylcholine in the cortex was increased. Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, R D -- Kellar, K J -- 507 RR05360-20/RR/NCRR NIH HHS/ -- GM07443/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):214-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828889" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Animals ; Brain/*physiology ; Brain Chemistry/drug effects ; Cerebral Cortex/analysis/physiology ; Isoflurophate/pharmacology ; Male ; Nicotine/metabolism/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*physiology ; Receptors, Nicotinic/analysis/*physiology
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    Recombination during gene transfer into mouse cells can restore the function of deleted genes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-14
    Description: Two plasmids containing nonoverlapping deletions of the herpes simplex virus thymidine kinase gene were introduced into thymidine kinase-deficient mouse L cells by DNA-mediated gene transfer. Thymidine kinase-producing transformants were generated by a mixture of the two plasmids at a frequency significantly greater than that generated by either plasmid alone. Southern blot analyses demonstrated that functional thymidine kinase genes were generated by homologous recombination between the two deletion mutants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Small, J -- Scangos, G -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6294829" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cells, Cultured ; Chromosome Deletion ; *Genetic Engineering ; Mice ; Mutation ; *Plasmids ; *Recombination, Genetic ; Simplexvirus ; Thymidine Kinase/*genetics
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    Gene transfer by polyoma-like particles assembled in a cell-free system (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: Empty capsids of polyoma virus interact with DNA in a cell-free system to form polyoma-like particles (PLP). The DNA in these particles is protected from the action of pancreatic deoxyribonuclease. Transfer of genetic information by PLP has been accomplished by using a restriction fragment containing the transforming sequences of polyoma DNA as a model gene. Infection of rat F111 cells by PLP containing these sequences results in DNA-mediated cellular transformation. Gene transfer by PLP is 50 to 150 times more efficient than by the calcium phosphate precipitation method.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slilaty, S N -- Aposhian, H V -- New York, N.Y. -- Science. 1983 May 13;220(4598):725-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Viral ; Cell-Free System ; DNA/genetics/*metabolism ; DNA, Viral/genetics/metabolism ; Genes, Viral ; Polyomavirus/*genetics ; Rats
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  • 69
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    Extracts of skeletal muscle increase neurite outgrowth and cholinergic activity of fetal rat spinal motor neurons (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-04
    Description: A soluble extract of rat skeletal muscle increased neurite outgrowth and cholinergic activity of dissociated ventral spinal neurons in culture. The effects were concentration-dependent, saturable, and labile in the presence of heat or trypsin. The morphological enhancement was produced only by skeletal muscle extract and decreased with developmental age, whereas the cholinergic enhancement was produced by extracts of cerebral cortex and cardiac and skeletal muscle and did not change with age. These changes were specific for ventral cord neurons, but no species specificity was observed with respect to the muscle source or the neuronal target.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R G -- Appel, S H -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1079-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823568" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*biosynthesis ; Animals ; Ganglia, Spinal/cytology ; Motor Neurons/*growth & development/metabolism ; Muscles/embryology/*physiology ; Rats
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    Human macrophages armed with murine immunoglobulin G2a antibodies to tumors destroy human cancer cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-26
    Description: Macrophages isolated from tumor-bearing patients as well as cultured human monocytes express Fc receptors that cross-react strongly with murine immunoglobulins of the G2a but only slightly or not at all with the G1, G2b, or G3 subclasses. Such macrophages in the presence of murine immunoglobulin G2a monoclonal antibodies to tumors mediated the killing of tumor cells in vitro. These data suggest that monoclonal antibodies of the G2a subclass may be useful in the immunotherapy of human cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steplewski, Z -- Lubeck, M D -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- CA-25874/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):865-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879183" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Cells, Cultured ; Cytotoxicity, Immunologic ; Humans ; *Immunity, Cellular ; Immunoglobulin G/immunology ; Immunotherapy ; Macrophages/*immunology ; Mice ; Monocytes/immunology ; Neoplasms, Experimental/immunology/therapy ; Receptors, Fc/*immunology ; Species Specificity
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    Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Kammen, D P -- Mann, L S -- Sternberg, D E -- Scheinin, M -- Ninan, P T -- Marder, S R -- van Kammen, W B -- Rieder, R O -- Linnoila, M -- New York, N.Y. -- Science. 1983 May 27;220(4600):974-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6133351" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Animals ; Antipsychotic Agents/adverse effects ; Atrophy ; Brain/metabolism/*pathology ; Dopamine/metabolism ; Dopamine beta-Hydroxylase/*cerebrospinal fluid ; Homovanillic Acid/*cerebrospinal fluid ; Humans ; Middle Aged ; Phenylacetates/*cerebrospinal fluid ; Rats ; Schizophrenia/*cerebrospinal fluid ; Tomography, X-Ray Computed
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    Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-16
    Description: A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil, an inhibitor of aldose reductase. Since the basement membrane thickening was ultrastructurally similar to that typical of diabetic retinopathy, it may indicate changes in vessel permeability and susceptibility to hemorrhage. Galactosemic rats should be useful models for studying basement membrane-related complications of diabetes and for examining the potential biochemical regulation of basement membrane synthesis by aldose reductase inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robison, W G Jr -- Kador, P F -- Kinoshita, J H -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612330" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basement Membrane/*pathology ; Capillaries/pathology ; Diabetic Retinopathy/etiology ; Disease Models, Animal ; Galactosemias/drug therapy/*pathology ; Imidazoles/*therapeutic use ; *Imidazolidines ; Male ; Rats ; Rats, Inbred Strains ; Retinal Vessels/*pathology
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    Hepatitis B virus infection in cultured human lymphoblastoid cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-12
    Description: Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for HBV surface antigen were identified in aspirates of bone marrow cells from people infected with HBV. These cells were used to prepare a lymphoblastoid suspension culture that contains HBV-infected cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romet-Lemonne, J L -- McLane, M F -- Elfassi, E -- Haseltine, W A -- Azocar, J -- Essex, M -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):667-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867736" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Hepatitis B/*microbiology/pathology ; Hepatitis B Surface Antigens/immunology ; Hepatitis B virus/growth & development ; Humans ; Liver/pathology ; Lymphocytes/*microbiology/pathology ; Male ; Middle Aged
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    Circumventing the blood-brain barrier with autonomic ganglion transplants (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-26
    Description: Superior cervical ganglia, whose vessels are fenestrated and permeable to protein tracers such as horseradish peroxidase, were transplanted to undamaged surfaces in the fourth ventricle of rat pup brains. Horseradish peroxidase, infused systemically into the host, was exuded from the graft's vessels into the graft's extracellular stroma within 1 minute. At later times the glycoprotein reached the extracellular clefts of adjacent brain tissue, the vessels of which appeared to retain their impermeability. The blood-brain barrier to horseradish peroxide was thus bypassed where the extracellular compartments of graft and brain became confluent. The graft of autonomic ganglia can serve as a portal through which peptides, hormones, and immunoglobulins may likewise enter the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenstein, J M -- Brightman, M W -- NS-17468/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):879-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood-Brain Barrier ; Cerebral Ventricles/*physiology ; Ganglia, Autonomic/blood supply/physiology/*transplantation ; Horseradish Peroxidase ; Rats
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    Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-02-25
    Description: Weekly transfusions of whole blood from a nondiabetic subline of BB/W rats reduced the incidence of diabetes in susceptible BB/W rats from 39 to 0 percent and the incidence of pancreatic insulitis from 64 to 6 percent. Responsiveness of lymphocytes to concanavalin A was found to be low in rats with diabetes or insulitis. Transfusion restored concanavalin A responsiveness to levels observed in control rats free of diabetes or insulitis. These data suggest that whole blood alters the course of autoimmune BB/W rat diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rossini, A A -- Mordes, J P -- Pelletier, A M -- Like, A A -- AM19155/AM/NIADDK NIH HHS/ -- AM25306/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):975-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823559" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood Transfusion ; Diabetes Mellitus, Experimental/*immunology/*prevention & control ; Macrophages/immunology ; Rats ; Rats, Mutant Strains
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    Immunoreactive dynorphin-(1-8) and corticotropin- releasing factor in subpopulation of hypothalamic neurons (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-14
    Description: Immunoreactive corticotropin-releasing factor (CRF) and dynorphin-(I-8) were visualized in rat hypothalamus by immunohistofluorescence with specific antibodies. In brains from colchicine-treated, adrenalectomized rats, neuronal perikarya with immunoreactive CRF were observed in the paraventricular nucleus of the hypothalamus. The CRF occurred together with the dynorphin-(1-8). However, the CRF immunoreactivity occurred only in a subpopulation of the dynorphin-(1-8) immunoreactive cells. These findings suggest that there may be a functional interrelationship of CRF with dynorphin-related opioid peptides and provide further evidence that neurons may contain more than one bioactive substance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, K A -- Weber, E -- Barchas, J D -- Chang, D -- Chang, J K -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6129700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corticotropin-Releasing Hormone/immunology/*metabolism ; Dynorphins ; Endorphins/immunology/*metabolism ; Fluorescent Antibody Technique ; Hypothalamus/cytology/*metabolism ; Neurons/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; Peptide Fragments/metabolism ; Rats
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    Dimethyl sulfoxide stimulates tyrosine residue phosphorylation of rat liver epidermal growth factor receptor (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-07
    Description: Epidermal growth factor, a potent mitogen, stimulates phosphorylation of its 170,000-dalton plasma membrane receptor. Dimethyl sulfoxide selectively increased phosphorylation of the epidermal growth factor receptor in rat liver microsomal fraction. Maximal stimulation occurred at 15 to 25 percent dimethyl sulfoxide and resembled the effect of epidermal growth factor in magnitude and rapidity. Like epidermal growth factor, dimethyl sulfoxide selectively stimulated tyrosine residue phosphorylation of this protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rubin, R A -- Earp, H S -- 5T32 CA 90156/CA/NCI NIH HHS/ -- AM-30002/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):60-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6294827" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dimethyl Sulfoxide/*pharmacology ; In Vitro Techniques ; Microsomes, Liver/metabolism ; Phosphorylation ; Rats ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*metabolism ; Tyrosine/metabolism
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    Synaptic activity mediates death of hypoxic neurons (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-29
    Description: Cultured hippocampal neurons, when exposed to cyanide or an anoxic atmosphere in the early stages of differentiation, were not visibly affected. However, neurons in the mature cultures died when exposed to cyanide or anoxia. Cell death could be prevented by treatment with magnesium, which eliminates synaptic activity. These observations suggest that damage in hypoxic neurons is mediated by synaptic activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rothman, S M -- 5 K07 N500568-02/PHS HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):536-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836300" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Anoxia/*metabolism/physiopathology ; Cells, Cultured ; Hippocampus/cytology ; Magnesium/pharmacology ; Magnesium Chloride ; Membrane Potentials/drug effects ; Neurons/metabolism/*physiology ; Rats ; Sodium Cyanide/pharmacology ; Synapses/drug effects/*physiology
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    A cancer-associated lactate dehydrogenase is expressed in normal retina (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-15
    Description: An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase k, is found in high concentrations in cultured cells transformed by the Kirsten murine sarcoma virus and in many human cancer tissues. In experiments described here high levels of a lactate dehydrogenase k activity were detected in extracts of normal rodent retina. This activity had the same key properties as the human tumor isozyme, namely, a highly cathodic electrophoretic mobility and inhibition of enzymatic activity by oxygen and 5',5'-dipurinenucleoside tetraphosphates. Expression of this activity in the retina may be related to the high aerobic glycolysis characteristic of the retina, a metabolic feature shared with many tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saavedra, R A -- Anderson, G R -- CA32022/CA/NCI NIH HHS/ -- GM28098/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 15;221(4607):291-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857286" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Transformation, Neoplastic/metabolism ; Chickens ; Electrophoresis ; Glycolysis ; Guinea Pigs ; Humans ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Mice ; Mice, Inbred Strains ; Neoplasms/*enzymology ; Oxygen/pharmacology ; Rats ; Retina/*enzymology
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    Infection of normal human epithelial cells by Epstein-Barr virus (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-11
    Description: Primary cultures of epithelial cells were grown from the tonsils and adenoids of patients with diseases not related to Epstein-Barr virus. The cells could not be infected by Epstein-Barr virus. Fluorescein-labeled Epstein-Barr virus and a cytofluorograph were then used to show that the epithelial cells do not have detectable receptors for the virus. However, implantation with Epstein-Barr virus receptors gave the cells the ability to bind the labeled virus. One to 5 percent of receptor-implanted cells exposed to the transforming B95-8 substrain of the virus expressed Epstein-Barr nuclear antigen. The early and viral capsid Epstein-Barr virus-determined antigens were not detected in the virus-infected cultures. The results show that normal human epithelial cells from the nasopharynx become susceptible to infection by Epstein-Barr virus when the membrane barrier resulting from the lack of viral receptors is overcome by receptor implantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, I M -- Volsky, D J -- 1R01 CA33386-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 11;219(4589):1225-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6298935" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Epithelium/*microbiology ; Herpesviridae Infections/*microbiology ; Herpesvirus 4, Human/growth & development ; Humans ; Receptors, Virus/metabolism ; Virus Replication
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    [123I]Insulin metabolism in normal rats and humans: external detection by a scintillation camera (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-18
    Description: [123I]Insulin was injected intravenously into rats and the distribution and kinetics of radioactivity were analyzed by external detection with a scintillation camera connected to a computer. When injected alone, [123I]insulin was rapidly taken up by the liver and to a smaller extent by the kidneys. After reaching a maximum at 3 to 5 minutes after injection, liver radioactivity rapidly declined and free iodide appeared in the plasma. After previous saturation of the insulin receptor compartment, [123I]insulin was concentrated by the kidneys only and the rate of appearance of free iodide was markedly decreased. The results demonstrate the potential usefulness of this noninvasive technique to visualize insulin interaction with the liver and kidneys and to study the rate of insulin degradation by each organ in vivo. Preliminary experiments in man demonstrate its feasibility and low radiotoxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sodoyez, J C -- Sodoyez-Goffaux, F -- Guillaume, M -- Merchie, G -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):865-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6337399" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Insulin/*metabolism ; Kidney/*metabolism ; Liver/*metabolism ; Metabolic Clearance Rate ; Myocardium/metabolism ; Rats ; Tissue Distribution ; Urinary Bladder/metabolism
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  • 82
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    Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Amiloride inhibited the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium. Measurements of the ouabain-sensitive QO2 in the presence of nystatin, the tissue sodium and potassium contents of the tubules in suspension, and the sodium- and potassium-dependent adenosinetriphosphatase (Na,K-ATPase) activity of lysed tubule membranes indicated that the effect of amiloride was due to a direct inhibition of the Na,K-ATPase activity of the proximal tubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soltoff, S P -- Mandel, L J -- AM26816/AM/NIADDK NIH HHS/ -- GM29256/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):957-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302840" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Ion Channels/drug effects ; Kidney Tubules, Proximal/drug effects/*enzymology ; Nystatin/pharmacology ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Pyrazines/*pharmacology ; Rabbits ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors/metabolism
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  • 83
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    Axonal proteins of presynaptic neurons during synaptogenesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-23
    Description: Changes occur in the synthesis and axonal transport of neuronal proteins in dorsal-root ganglia axons as a result of contact with cells from the spinal cord during synapse formation. Dorsal-root ganglia cells were cultured in a compartmental cel culture system that allows separate access to neuronal cell bodies and their axons. When cells from the ventral spinal cord were cultured with the dorsal-root ganglia axons, synapses were established within a few days. Metabolic labeling and two-dimensional electrophoresis revealed that four of more than 300 axonal proteins had changed in their expression by the time synapses were established. The highly selective nature of these changes suggests that the proteins involved may be important in the processes of axon growth and synapse formation and their regulation by the regional environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sonderegger, P -- Fishman, M C -- Bokoum, M -- Bauer, H C -- Nelson, P G -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1294-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612344" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*metabolism ; Cells, Cultured ; Chick Embryo ; Isoelectric Point ; Molecular Weight ; Nerve Tissue Proteins/*biosynthesis ; Synapses/*metabolism
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  • 84
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    Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-04
    Description: Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica. The effects of these toxins on cultured mouse neuroblastoma and fibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spector, I -- Shochet, N R -- Kashman, Y -- Groweiss, A -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):493-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681676" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; Animals ; *Bicyclo Compounds, Heterocyclic ; Cells, Cultured ; Cytoskeleton/*drug effects ; Fibroblasts/ultrastructure ; Marine Toxins/*pharmacology ; Microscopy, Fluorescence ; Microtubules/drug effects ; Neuroblastoma/ultrastructure ; Thiazoles/*pharmacology ; Thiazolidines
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  • 85
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    Trypsin inhibition by tapeworms: antienzyme secretion or pH adjustment? (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-01
    Description: The tapeworm Hymenolepis diminuta releases proteins that inhibit trypsin activity. These proteins may be either antienzymes or nonspecific macromolecules that interfere with trypsin. Saline solutions with initial pH values ranging from 5.5 to 10.0 were all acidified to pH 5.0 by tapeworms. If the initial pH was lower than 5.0, it was raised. Because trypsin activity is inhibited at pH 5.0, this intestinal parasite can protect itself from digestion by regulating its environmental pH or releasing trypsin inhibitors, or both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Uglem, G L -- Just, J J -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828882" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hydrogen-Ion Concentration ; Hymenolepis/*physiology ; Intestines/parasitology ; Oxygen/metabolism ; Partial Pressure ; Rats ; Trypsin Inhibitors/*metabolism/secretion
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  • 86
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    Hypothalamic gamma-aminobutyric acid neurons project to the neocortex (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-17
    Description: Three groups of gamma-aminobutyric acid--containing neurons were found in the mammillary region of the posterior hypothalamus. The groups correspond to the tuberal, caudal, and postmammillary caudal magnocellular nuclei. Many cells in these nuclei were retrogradely labeled with fast blue after the injection of this fluorescent dye into the neocortex. Immunohistochemical experiments showed that these same neurons also contained the gamma-aminobutyric acid-synthesizing enzyme glutamate decarboxylase. These results provide morphological evidence for a gamma-aminobutyric acid pathway arising in magnocellular neurons of the posterior hypothalamus and innervating the neocortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, S R -- Hokfelt, T -- Skirboll, L R -- Wu, J Y -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857253" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*anatomy & histology/cytology ; Glutamate Decarboxylase/physiology ; Hypothalamus/*anatomy & histology ; Hypothalamus, Posterior/*anatomy & histology/cytology ; Microscopy, Fluorescence ; Neural Pathways/anatomy & histology ; Rats ; gamma-Aminobutyric Acid/*physiology
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  • 87
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    Single-channel fluctuations in bimolecular lipid membranes induced by rat olfactory epithelial homogenates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-13
    Description: Chemosensitive single-channel fluctuations were observed to be induced in essentially solvent-free lipid bimolecular membranes by the addition of sonicated homogenates of rat olfactory epithelium. The chemosensitive channels were not observed when respiratory epithelium homogenates were used instead. Ionic selectivity is consistent with potassium ions as the charge carrier. These channels may be associated with the initial events of chemoreception in the rat olfactory epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vodyanoy, V -- Murphy, R B -- New York, N.Y. -- Science. 1983 May 13;220(4598):717-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Chemoreceptor Cells/physiology ; Epithelium/physiology ; Ion Channels/*drug effects ; Male ; Membranes/drug effects ; Olfactory Mucosa/*physiology ; Rats ; Rats, Inbred Strains ; Smell/physiology
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  • 88
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    Dopamine modulation of the effects of gamma-aminobutyric acid on substantia nigra pars reticulata neurons (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-08
    Description: Studies were conducted to assess whether basal ganglia output neurons originating in the substantia nigra pars reticulata might be affected by dopamine released from dendrites of neighboring substantia nigra pars compacta neurons. Dopamine applied by iontophoresis increased the baseline firing rates of approximately half of the substantia nigra pars reticulata cells tested. The more significant finding, unrelated to the increase in firing, was the ability of dopamine to attenuate the inhibitory responses of these cells to iontophoretically applied gamma-aminobutyric acid. These findings suggest a role for dopamine as a neuromodulator and further suggest that it can act at sites beyond the striatum to modify transmission from the basal ganglia to motor nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waszcak, B L -- Walters, J R -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):218-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828891" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Dopamine/*pharmacology ; Iontophoresis ; Male ; Neurons/*drug effects ; Norepinephrine/pharmacology ; Rats ; Rats, Inbred Strains ; Substantia Nigra/*drug effects ; gamma-Aminobutyric Acid/*pharmacology
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  • 89
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    Effects of tyrosine administration on serum biopterin in normal controls and patients with Parkinson's disease (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-07
    Description: After administration of tyrosine, total concentration of biopterin, the cofactor for tyrosine hydroxylase, was increased in the striatum, adrenal glands, and serum of rats, and in the serum of humans. Serum biopterin is lower in patients with Parkinson's disease than in normal controls. After oral administration of tyrosine, the increase in serum biopterin concentration was smaller in patients with Parkinson's disease (less than twofold) than in healthy controls (three-to sevenfold). These results suggest that tyrosine may have a regulatory role in biopterin biosynthesis and that patients with Parkinson's disease may have some abnormality in the regulation of biopterin biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamaguchi, T -- Nagatsu, T -- Sugimoto, T -- Matsuura, S -- Kondo, T -- Iizuka, R -- Narabayashi, H -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849120" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Adrenal Glands/metabolism ; Alanine/pharmacology ; Animals ; Biopterin/*blood ; Corpus Striatum/metabolism ; Humans ; Injections, Intraperitoneal ; Liver/metabolism ; Male ; Parkinson Disease/*blood ; Pteridines/*blood ; Rats ; Rats, Inbred Strains ; Time Factors ; Tyrosine/administration & dosage/*pharmacology
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  • 90
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    Conditioned cues elicit feeding in sated rats: a role for learning in meal initiation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-22
    Description: Pavlovian conditioning was used to teach rats an association between an arbitrary external cue and food. Presentation of the conditioned cue elicited feeding by sated animals. The meal constituted approximately 20 percent of daily intake, and it was compensated for by a reduction of subsequent intake.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weingarten, H P -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):431-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836286" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conditioning, Classical ; *Eating ; Energy Metabolism ; Feeding Behavior ; Humans ; Male ; Rats ; *Satiation ; Vagotomy
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  • 91
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    Glucose stimulation of the antilipolytic effect of insulin in humans (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-03
    Description: Dose-response studies of the inhibition of lipolysis by insulin in isolated human adipocytes were conducted with the use of a sensitive bioluminescent assay of glycerol release. The addition of glucose to the incubation medium was associated with an increase in insulin sensitivity and an increase in the maximum insulin effect. The results suggest that glucose plays an important role in regulating the antilipolytic action of insulin in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arner, P -- Bolinder, J -- Ostman, J -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1057-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6342138" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/cytology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Synergism ; Glucose/*pharmacology ; Humans ; Insulin/*pharmacology ; Isoproterenol/pharmacology ; Lipolysis/*drug effects
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  • 92
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    Haloperidol-induced plasticity of axon terminals in rat substantia nigra (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-02
    Description: An electron micrographic morphometric analysis of nerve endings in substantia nigra of rats repeatedly treated with haloperidol was performed. Although most parameters showed no difference, drug-treated animals exhibited a significant shift in the distribution of relative numbers of axon terminals, suggesting neuroleptic-induced axon-collateral sprouting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benes, F M -- Paskevich, P A -- Domesick, V B -- 1K01 MH00423-01/MH/NIMH NIH HHS/ -- MH31154-06/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):969-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879197" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/drug effects ; Dendrites/drug effects ; Haloperidol/*pharmacology ; Male ; Microscopy, Electron ; Movement/drug effects ; Neuronal Plasticity/*drug effects ; Rats ; Substantia Nigra/drug effects/*physiology
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  • 93
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    Endogenous inhibitors of monoamine oxidase present in human cerebrospinal fluid (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-29
    Description: Inhibitory activity against the enzyme monoamine oxidase is present in low molecular weight fractions (less than 100,000) of human cerebrospinal fluid. These endogenous substances of different molecular weights (3000 to more than 35,000) act like monoamine oxidase inhibitor drugs to inhibit both type A and type B monoamine oxidase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, R E -- Giambalvo, C -- Fox, R A -- Macho, M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):476-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867724" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebrospinal Fluid/*physiology ; Chromatography, Gel ; Humans ; Molecular Weight ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/*isolation & purification ; Rats
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  • 94
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    The immune response evokes changes in brain noradrenergic neurons (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-05
    Description: A decreased noradrenaline turnover in the hypothalami of rats was observed at the peak of the immune response to sheep red blood cells. The decrease in noradrenergic neuronal activity was mimicked by injection of soluble r mediators released by immunological cells activated in vitro. Noradrenaline also tended to decrease in the brainstem but not in the residual brain. It is suggested that products released from activated immunological cells during the immune response may induce the previously described autonomic and endocrine mechanisms that contribute to immunoregulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Besedovsky, H -- del Rey, A -- Sorkin, E -- Da Prada, M -- Burri, R -- Honegger, C -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):564-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867729" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*immunology/physiology ; Brain Stem/immunology/physiology ; Female ; Hypothalamus/immunology/physiology ; *Immunity ; Norepinephrine/*physiology ; Rats ; Sheep/immunology ; Spleen/immunology/physiology
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  • 95
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    Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: Inhibiting protein synthesis by incubating C6-2B rat astrocytoma cells with cycloheximide or emetine for periods up to 24 hours caused a progressive decrease in the accumulation of adenosine 3',5'-monophosphate (cyclic AMP) when the cells were challenged for 30 minutes with 100 microM forskolin. In contrast, cholera toxin-stimulated (6 nM, 3 hours) cyclic AMP accumulation was not diminished in cycloheximide-treated cells, and cyclic AMP was only minimally diminished in response to a 30-minute challenge with 10 microM (-)-isoproterenol. These experiments suggest the presence of a previously unrecognized cyclase component, which is essential for forskolin-stimulated cyclic AMP accumulation and has a shorter half-life than the beta-adrenergic receptor, the guanine nucleotide regulatory proteins, or the cyclase catalytic component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brooker, G -- Pedone, C -- Barovsky, K -- HL 06330/HL/NHLBI NIH HHS/ -- HL 28940/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1169-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6190226" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytoma/metabolism ; Cell Line ; Cholera Toxin/pharmacology ; Colforsin ; Cyclic AMP/*biosynthesis/physiology ; Cycloheximide/pharmacology ; Dichlororibofuranosylbenzimidazole/pharmacology ; Diterpenes/*pharmacology ; Emetine/pharmacology ; Isoproterenol/pharmacology ; *Protein Biosynthesis ; RNA/biosynthesis ; Rats
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  • 96
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    A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-23
    Description: A peptide that accumulated as the major product during the proteolysis of arginine vasopressin by rat brain synaptic membranes was isolated and its structure was shown to be the hexapeptide pGlu-Asn-Cys(Cys)-Pro-Arg-Gly-NH2. When administered intracerebroventricularly in extremely low doses, this vasopressin fragment and its desglycinamide derivative facilitated memory consolidation in a passive avoidance situation. These vasopressin metabolites, which are devoid of pressor activity, constitute highly potent neuropeptides with selective effects on memory and related processes; they are activated via proteolytic processing of vasopressin by brain peptidases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burbach, J P -- Kovacs, G L -- de Wied, D -- van Nispen, J W -- Greven, H M -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1310-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6351252" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Arginine Vasopressin/*metabolism/physiology ; Avoidance Learning/physiology ; Brain/*metabolism ; Dose-Response Relationship, Drug ; Male ; Memory/*physiology ; Oligopeptides/metabolism ; Peptide Hydrolases/metabolism ; Rats ; Structure-Activity Relationship
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  • 97
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    Ethanol modulation of opiate receptors in cultured neural cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: The mouse neuroblastoma-rat glioma hybrid cell line NG108-15 was used to study the acute and chronic interaction of ethanol with intact neural cells. In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn. High concentrations of ethanol (200 mM) increased opiate binding after 18 to 24 hours, whereas lower concentrations (25 to 50 mM) produced similar changes after 2 weeks. This model system has potential for exploring the cellular and molecular mechanisms underlying ethanol intoxication, tolerance, and withdrawal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charness, M E -- Gordon, A S -- Diamond, I -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316506" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Dose-Response Relationship, Drug ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Ethanol/*pharmacology ; Glioma ; Hybrid Cells ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Rats ; Receptors, Opioid/*drug effects/metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 98
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    Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-25
    Description: Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine receptor supersensitivity after a unilateral lesion of the substantia nigra. The authors report that this effect of transplantation is specific to grafts of substantia nigra. They also report that, in conjunction with the decrease in motor asymmetry, these grafts cause postsynaptic dopaminergic binding sites to return to normal density as measured by tritiated spiroperidol autoradiography. Thus, in animals with brain lesions, grafts of substantia nigra produce a long-term alteration in the functional status of host brain cell receptors that is associated with a reduction in the behavioral deficit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Ko, G N -- Niehoff, D L -- Kuhar, M J -- Hoffer, B J -- Olson, L -- Cannon-Spoor, H E -- Morihisa, J M -- Wyatt, R J -- MH-00289/MH/NIMH NIH HHS/ -- MH-25951/MH/NIMH NIH HHS/ -- NS-09199/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):937-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635666" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Autoradiography ; Denervation ; Dextroamphetamine/pharmacology ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/*metabolism ; Spiperone/metabolism ; Substantia Nigra/*transplantation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-10-28
    Description: The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doolittle, R F -- RR 00757/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6604942" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Angiotensinogen/*genetics ; Angiotensins/*genetics ; Animals ; Antithrombins/genetics ; *Biological Evolution ; Macromolecular Substances ; Ovalbumin/genetics ; Rats ; alpha 1-Antitrypsin/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 100
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    Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: Lipid peroxidation triggered by ascorbate or reduced nicotinamide adenine dinucleotide in rat liver microsomes can initiate the epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene. The stereochemistry of epoxidation is indicative of a peroxide-dependent free radical process. Since the epoxides formed may be the most carcinogenic derivatives of benzo[a]pyrene yet identified, lipid peroxidation can effect the metabolic activation of proximate carcinogens to ultimate carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dix, T A -- Marnett, L J -- GM 23642/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304879" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzo(a)pyrene ; Benzopyrenes/metabolism ; Carcinogens/*metabolism ; *Dihydroxydihydrobenzopyrenes ; Epoxy Compounds/metabolism ; Lipid Peroxides/*metabolism ; Microsomes, Liver/metabolism ; NADP/metabolism ; Oxidation-Reduction ; Polycyclic Compounds/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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