Publication Date:
2022-07-15
Description:
© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Horb, M., Abu-Daya, A., Wlizla, M., Noble, A., & Guille, M. “Advances in genome editing tools.” In Xenopus, edited by Abraham Fainsod, Sally A. Moody, 207–221. Boca Raton: CRC Press, 2022, https://doi.org/10.1201/9781003050230-16.
Description:
This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge in cell biology, developmental biology, molecular biology, and neurobiology. In recent years, with the completion of the genome sequence of the main two species and the application of genome editing techniques, Xenopus has emerged as a powerful system to study fundamental disease mechanisms and test treatment possibilities. Xenopus has proven an essential vertebrate model system for understanding fundamental cell and developmental biological mechanisms, for applying fundamental knowledge to pathological processes, for deciphering the function of human disease genes, and for understanding genome evolution.
Key Features
Provides historical context of the contributions of the model system
Includes contributions from an international team of leading scholars
Presents topics spanning cell biology, developmental biology, genomics, and disease model
Describes recent experimental advances
Incorporates richly illustrated diagrams and color images
Description:
The NXR is funded by grants from the National Institutes of Health (P40OD010997, R24OD030008, and R01HD084409). The EXRC is supported by grants from the Wellcome Trust (212942/Z/18/Z) and BBSRC (BB/R014841/1).
Repository Name:
Woods Hole Open Access Server
Type:
Book chapter
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