The 2023 MDPI Annual Report has
been released!
 
18 pages, 7401 KiB  
Article
Hydrogels and Carbon Nanotubes: Composite Electrode Materials for Long-Term Electrocardiography Monitoring
by Leszek Kolodziej, Olga Iwasińska-Kowalska, Grzegorz Wróblewski, Tomasz Giżewski, Małgorzata Jakubowska and Agnieszka Lekawa-Raus
J. Funct. Biomater. 2024, 15(5), 113; https://doi.org/10.3390/jfb15050113 (registering DOI) - 23 Apr 2024
Abstract
This paper presents methods for developing high-performance interface electrode materials designed to enhance signal collection efficacy during long-term (over 24 h) electrocardiography (ECG) monitoring. The electrode materials are fabricated by integrating commercial ECG liquid hydrogels with carbon nanotubes (CNTs), which are widely utilized [...] Read more.
This paper presents methods for developing high-performance interface electrode materials designed to enhance signal collection efficacy during long-term (over 24 h) electrocardiography (ECG) monitoring. The electrode materials are fabricated by integrating commercial ECG liquid hydrogels with carbon nanotubes (CNTs), which are widely utilized in dry-electrode technologies and extensively discussed in the current scientific literature. The composite materials are either prepared by dispersing CNTs within the commercial liquid hydrogel matrix or by encasing the hydrogels in macroscopic CNT films. Both approaches ensure the optimal wetting of the epidermis via the hydrogels, while the CNTs reduce material impedance and stabilize the drying process. The resulting electrode materials maintain their softness, allowing for micro-conformal skin attachment, and are biocompatible. Empirical testing confirms that the ECG electrodes employing these hybrid hydrogels adhere to relevant standards for durations exceeding 24 h. These innovative hybrid solutions merge the benefits of both wet and dry ECG electrode technologies, potentially facilitating the extended monitoring of ECG signals and thus advancing the diagnosis and treatment of various cardiac conditions. Full article
(This article belongs to the Section Biomaterials and Devices for Healthcare Applications)
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27 pages, 7292 KiB  
Article
Mantle Sources and Geochemical Evolution of the Picture Gorge Basalt, Columbia River Basalt Group
by Emily B. Cahoon, Martin J. Streck, Richard W. Carlson and Ilya N. Bindeman
Minerals 2024, 14(5), 440; https://doi.org/10.3390/min14050440 (registering DOI) - 23 Apr 2024
Abstract
The Columbia River Basalt Group (CRBG) is the youngest continental flood basalt province, proposed to be sourced from the deep-seated plume that currently resides underneath Yellowstone National Park. If so, the earliest erupted basalts from this province, such as those in the Picture [...] Read more.
The Columbia River Basalt Group (CRBG) is the youngest continental flood basalt province, proposed to be sourced from the deep-seated plume that currently resides underneath Yellowstone National Park. If so, the earliest erupted basalts from this province, such as those in the Picture Gorge Basalt (PGB), aid in understanding and modeling plume impingement and the subsequent evolution of basaltic volcanism. Using geochemical and isotopic data, this study explores potential mantle sources and magma evolution of the PGB. Long known geochemical signatures of the PGB include overall large ion lithophile element (LILE) enrichment and relative depletion of high field strength elements (HFSE) typical of other CRBG main-phase units. Basaltic samples of the PGB have 87Sr/86Sr ratios on the low end of the range displayed by other CRBG lavas and mantle-like δ18O values. The relatively strong enrichment of LILE and depletion of HFSE coupled with depleted isotopic signatures suggest a metasomatized upper mantle as the most likely magmatic source for the PGB. Previous geochemical modeling of the PGB utilized the composition of two high-MgO primitive dikes exposed in the northern portion of the Monument Dike swarm as parental melt. However, fractionation of these dike compositions cannot generate the compositional variability illustrated by basaltic lavas and dikes of the PGB. This study identifies a second potential parental PGB composition best represented by basaltic flows in the extended spatial distribution of the PGB. This composition also better reflects the lowest stratigraphic flows identified in the previously mapped extent of the PGB. Age data reveal that PGB lavas erupted first and throughout eruptions of main-phase CRBG units (Steens, Imnaha, Grande Ronde Basalt). Combining geochemical signals with these age data indicates cyclical patterns in the amounts of contributing mantle components. Eruption of PGB material occurred in two pulses, demonstrated by a ~0.4 Ma temporal gap in reported ages, 16.62 to 16.23 Ma. Coupling ages with observed geochemical signals, including relative elemental abundances of LILE, indicates increased influence of a more primitive, potentially plume-like source with time. Full article
(This article belongs to the Special Issue Large Igneous Provinces: Research Frontiers)
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13 pages, 4215 KiB  
Article
The Development of Multi-Resistant Rice Restorer Lines and Hybrid Varieties by Pyramiding Resistance Genes against Blast and Brown Planthopper
by Zhao Deng, Peng Qin, Kaiyu Liu, Nan Jiang, Tianze Yan, Xuanwen Zhang, Chenjian Fu, Guangcun He, Kai Wang and Yuanzhu Yang
Agronomy 2024, 14(5), 878; https://doi.org/10.3390/agronomy14050878 (registering DOI) - 23 Apr 2024
Abstract
Rice blast, caused by the fungus Magnaporthe oryzae, and brown planthopper (BPH) infestation are two of the most destructive problems of rice production in China. The development of multi-resistant varieties is widely recognized as the most efficient and environmentally friendly approach to [...] Read more.
Rice blast, caused by the fungus Magnaporthe oryzae, and brown planthopper (BPH) infestation are two of the most destructive problems of rice production in China. The development of multi-resistant varieties is widely recognized as the most efficient and environmentally friendly approach to controlling crop diseases and pests. Functional molecular markers (FMMs) have been developed from functional variants in the genic region associated with trait variation, greatly enhancing the efficiency of identifying and pyramiding valuable genes in crop breeding. In this study, two FMMs and a multiplex PCR amplification system were developed for two major broad-spectrum BPH resistance genes, Bph6 and Bph9. With the assistance of FMMs in the multi-resistant rice restorer-line development pipeline, two lines (Huahui7713 and Huahui3006) with blast and BPH resistance were developed by pyramiding three resistance genes Pigm, Bph6 and Bph9. Two new hybrid rice varieties, Weiliangyou7713 and Xuanliangyou3006, derived from Huahui7713 and Huahui3006, have been developed and commercialized in China. Weiliangyou7713 and Xuanliangyou3006 exhibit enhanced resistance to both blast and BPH, while maintaining optimal yield and grain quality. The adoption of Weiliangyou7713 continues to expand, now being cultivated on a large scale, which is promising for its future role in reducing the dependence on chemical fungicides and pesticides in rice production. This suggests that the implementation of Huahui7713 and Huahui3006 in targeted breeding programs could be highly beneficial for developing rice varieties with strong resistance to blast and BPH. Full article
(This article belongs to the Section Crop Breeding and Genetics)
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22 pages, 5098 KiB  
Article
Rationalizing Graphene–ZnO Composites for Gas Sensing via Functionalization with Amines
by Maxim K. Rabchinskii, Victor V. Sysoev, Maria Brzhezinskaya, Maksim A. Solomatin, Vladimir S. Gabrelian, Demid A. Kirilenko, Dina Yu. Stolyarova, Sviatoslav D. Saveliev, Alexander V. Shvidchenko, Polina D. Cherviakova, Alexey S. Varezhnikov, Sergey I. Pavlov, Sergei A. Ryzhkov, Boris G. Khalturin, Nikita D. Prasolov and Pavel N. Brunkov
Nanomaterials 2024, 14(9), 735; https://doi.org/10.3390/nano14090735 (registering DOI) - 23 Apr 2024
Abstract
The rational design of composites based on graphene/metal oxides is one of the pillars for advancing their application in various practical fields, particularly gas sensing. In this study, a uniform distribution of ZnO nanoparticles (NPs) through the graphene layer was achieved, taking advantage [...] Read more.
The rational design of composites based on graphene/metal oxides is one of the pillars for advancing their application in various practical fields, particularly gas sensing. In this study, a uniform distribution of ZnO nanoparticles (NPs) through the graphene layer was achieved, taking advantage of amine functionalization. The beneficial effect of amine groups on the arrangement of ZnO NPs and the efficiency of their immobilization was revealed by core-level spectroscopy, pointing out strong ionic bonding between the aminated graphene (AmG) and ZnO. The stability of the resulting Am-ZnO nanocomposite was confirmed by demonstrating that its morphology remains unchanged even after prolonged heating up to 350 °C, as observed by electron microscopy. On-chip multisensor arrays composed of both AmG and Am-ZnO were fabricated and thoroughly tested, showing almost tenfold enhancement of the chemiresistive response upon decorating the AmG layer with ZnO nanoparticles, due to the formation of p-n heterojunctions. Operating at room temperature, the fabricated multisensor chips exhibited high robustness and a detection limit of 3.6 ppm and 5.1 ppm for ammonia and ethanol, respectively. Precise identification of the studied analytes was achieved by employing the pattern recognition technique known as linear discriminant analysis to process the acquired multisensor response. Full article
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16 pages, 4197 KiB  
Article
Genomic Characterization and Molecular Detection of Rehmannia Allexivirus Virus, a Novel Allexivirus Infecting Rehmannia glutinosa
by Yanhong Qin, Shuhao Lu, Yi Wen, Shaojian Li, Suxia Gao, Yuxia Liu, Xuemeng Li, Jin Yang, Fengli Wang, Fei Wang and Chuantao Lu
Microorganisms 2024, 12(5), 844; https://doi.org/10.3390/microorganisms12050844 (registering DOI) - 23 Apr 2024
Abstract
Rehmannia glutinosa is one of the most important medicinal plants in China and is affected by viral diseases. In this study, a new virus tentatively named Rehmannia Allexivirus virus (ReAV) was identified through high-throughput sequencing, reverse-transcription polymerase chain reaction (RT-PCR), and Sanger sequencing. [...] Read more.
Rehmannia glutinosa is one of the most important medicinal plants in China and is affected by viral diseases. In this study, a new virus tentatively named Rehmannia Allexivirus virus (ReAV) was identified through high-throughput sequencing, reverse-transcription polymerase chain reaction (RT-PCR), and Sanger sequencing. The complete genome length was 7297 nt and it contained five open reading frames (ORFs) encoding replicase, triple gene block 1(TGB1), TGB2, TGB3, and coat protein (CP). The replicase and CP presented nucleotide homology ranges of 59.9–65.2% and 47.5–55.5% between the nine ReAV isolates and the other 12 species of the genus Allexivirus. In the nine isolates, ReAV-20 and ReAV-31 isolates showed breakpoints in the replicase and CP regions, respectively. The other isolates shared 87.2–96.5% nt with the whole genome nucleotide identity. The phylogenetic tree showed that seven ReAV isolates based on replicase, CP, and whole genome sequences were clustered in the same branch and were related to the genus Allexivirus. The ReAV detection rates for 60 R. glutinosa samples were 73.3–81.7% through RT-PCR using primers targeting the replicase or CP genes. These results demonstrate that ReAV is the dominant virus in R. glutinosa. This study provides important evidence for understanding viruses infecting R. glutinosa and for establishing efficient strategies to prevent viral spread. Full article
(This article belongs to the Section Microbial Biotechnology)
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25 pages, 5444 KiB  
Article
An Enhanced Mechanism for Fault Tolerance in Agricultural Wireless Sensor Networks
by Mounya Smara and Al-Sakib Khan Pathan
Network 2024, 4(2), 150-174; https://doi.org/10.3390/network4020008 (registering DOI) - 23 Apr 2024
Abstract
Fault tolerance is a critical aspect for any wireless sensor network (WSN), which can be defined in plain terms as the quality of being dependable or performing consistently well. In other words, it may be described as the effectiveness of fault tolerance in [...] Read more.
Fault tolerance is a critical aspect for any wireless sensor network (WSN), which can be defined in plain terms as the quality of being dependable or performing consistently well. In other words, it may be described as the effectiveness of fault tolerance in the event of crucial component failures in the network. As a WSN is composed of sensors with constrained energy resources, network disconnections and faults may occur because of a power failure or exhaustion of the battery. When such a network is used for precision agriculture, which needs periodic and timely readings from the agricultural field, necessary measures are needed to handle the effects of such faults in the network. As climate change is affecting many parts of the globe, WSN-based precision agriculture could provide timely and early warnings to the farmers about unpredictable weather events and they could take the necessary measures to save their crops or to lessen the potential damage. Considering this as a critical application area, in this paper, we propose a fault-tolerant scheme for WSNs deployed for precision agriculture. Along with the description of our mechanism, we provide a theoretical operational model, simulation, analysis, and a formal verification using the UPPAAL model checker. Full article
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17 pages, 6358 KiB  
Article
Potential for Recycling Metakaolin/Slag-Based Geopolymer Concrete of Various Strength Levels in Freeze–Thaw Conditions
by Mengtong Liu, Hui Liu, Minqi Hua, Chunhong Chen, Xinjie Wang, Xiang Guo and Tianyu Ma
Materials 2024, 17(9), 1944; https://doi.org/10.3390/ma17091944 (registering DOI) - 23 Apr 2024
Abstract
Geopolymer concrete (GPC) represents an innovative green and low-carbon construction material, offering a viable alternative to ordinary Portland cement concrete (OPC) in building applications. However, existing studies tend to overlook the recyclability aspect of GPC for future use. Various structural applications necessitate the [...] Read more.
Geopolymer concrete (GPC) represents an innovative green and low-carbon construction material, offering a viable alternative to ordinary Portland cement concrete (OPC) in building applications. However, existing studies tend to overlook the recyclability aspect of GPC for future use. Various structural applications necessitate the use of concrete with distinct strength characteristics. The recyclability of the parent concrete is influenced by these varying strengths. This study examined the recycling potential of GPC across a spectrum of strength grades (40, 60, 80, and 100 MPa, marked as C40, C60, C80, and C100) when subjected to freeze–thaw conditions. Recycling 5–16 mm recycled geopolymer coarse aggregate (RGAs) from GPC prepared from 5 to 16 mm natural coarse aggregates (NAs). The cementitious material comprised 60% metakaolin and 40% slag, with natural gravel serving as the NAs, and the alkali activator consisting of sodium hydroxide solution and sodium silicate solution. The strength of the GPC was modulated by altering the Na/Al ratio. After 350 freeze–thaw cycles, the GPC specimens underwent crushing, washing, and sieving to produce RGAs. Subsequently, their physical properties (apparent density, water absorption, crushing index, and attached mortar content and microstructure (microhardness, SEM, and XRD) were thoroughly examined. The findings indicated that GPC with strength grades of C100, C80, and C60 were capable of enduring 350 freeze–thaw cycles, in contrast to C40, which did not withstand these conditions. RGAs derived from GPC of strength grades C100 and C80 complied with the criteria for Class II recycled aggregates, whereas RGAs produced from GPC of strength grade C60 aligned with the Class III level. A higher-strength grade in the parent concrete correlated with enhanced performance characteristics in the resulting recycled aggregates. Full article
(This article belongs to the Special Issue Research on Alkali-Activated Materials)
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12 pages, 2149 KiB  
Article
Recovery of Apatite from Magnetic Concentration Tailings by Flotation
by Luis Valderrama, Osvaldo Gómez, Osvaldo Pavez and Mario Santander
Minerals 2024, 14(5), 441; https://doi.org/10.3390/min14050441 (registering DOI) - 23 Apr 2024
Abstract
Iron concentration tailings contain many valuable minerals, including apatite, which is not currently being recovered despite its use to make fertilizers and chemicals. This article proposes a flotation circuit to recover apatite from tailings generated by mining in Chile, based on laboratory tests [...] Read more.
Iron concentration tailings contain many valuable minerals, including apatite, which is not currently being recovered despite its use to make fertilizers and chemicals. This article proposes a flotation circuit to recover apatite from tailings generated by mining in Chile, based on laboratory tests and using the “Split Factor” method. The iron tailings were characterized by granulometry, chemical and mineralogical analyses, zeta potential, and contact angle. The effect of the collector, frother, and dispersant dose, along with the number of flotation stages, on both the grade and recovery of P2O5 were studied. The results indicate that it is possible to produce concentrates with a P2O5 grade of 29.1% and 89.6% recovery in a flotation circuit that includes the rougher–scavenger–cleaner stages. To obtain these results, it is only necessary to condition the iron tailings with 400 gt−1 of Atrac-2600, 400 gt−1 of sodium silicate, 10 min of conditioning time, pH adjustment to 10, and a time for the rougher, cleaner, and scavenger stages set at 10, 7.6, and 6.8 min, respectively. A chemical interaction is suggested, where the collector is specifically adsorbed onto the apatite surface. Full article
(This article belongs to the Special Issue Reuse and Recycling of Phosphate Mine Wastes)
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15 pages, 304 KiB  
Article
The Optimal Stopping Problem Under a Random Horizon
by Tahir Choulli and Safa’ Alsheyab
Mathematics 2024, 12(9), 1273; https://doi.org/10.3390/math12091273 (registering DOI) - 23 Apr 2024
Abstract
This paper considers a pair (F,τ), where F is a filtration representing the “public” flow of information that is available to all agents over time, and τ is a random time that might not be an F-stopping [...] Read more.
This paper considers a pair (F,τ), where F is a filtration representing the “public” flow of information that is available to all agents over time, and τ is a random time that might not be an F-stopping time. This setting covers the case of a credit risk framework, where τ models the default time of a firm or client, and the setting of life insurance, where τ is the death time of an agent. It is clear that random times cannot be observed before their occurrence. Thus, the larger filtration, G, which incorporates F and makes τ observable, results from the progressive enlargement of F with τ. For this informational setting, governed by G, we analyze the optimal stopping problem in three main directions. The first direction consists of characterizing the existence of the solution to this problem in terms of F-observable processes. The second direction lies in deriving the mathematical structuresof the value process of this control problem, while the third direction singles out the associated optimal stopping problem under F. These three aspects allow us to deeply quantify how τ impacts the optimal stopping problem and are also vital for studying reflected backward stochastic differential equations that arise naturally from pricing and hedging of vulnerable claims. Full article
(This article belongs to the Section Financial Mathematics)
13 pages, 1061 KiB  
Article
The Changing Detection Rate of Respiratory Syncytial Virus in Adults in Western Australia between 2017 and 2023
by David A. Foley, Cara A. Minney-Smith, Andrew Tjea, Mark P. Nicol, Avram Levy, Hannah C. Moore and Christopher C. Blyth
Viruses 2024, 16(5), 656; https://doi.org/10.3390/v16050656 (registering DOI) - 23 Apr 2024
Abstract
The incidence of respiratory syncytial virus (RSV) in adults is inadequately defined and the impact of SARS-CoV-2-related non-pharmaceutical interventions (NPIs) is underexplored. Using laboratory data, we described the detection rate of RSV in adults ≥16 years in Western Australia (WA) between 2017 and [...] Read more.
The incidence of respiratory syncytial virus (RSV) in adults is inadequately defined and the impact of SARS-CoV-2-related non-pharmaceutical interventions (NPIs) is underexplored. Using laboratory data, we described the detection rate of RSV in adults ≥16 years in Western Australia (WA) between 2017 and 2023. With the exception of 2020, RSV detections rose annually between 2017 and 2023, reaching 50.7 per 100,000 in 2023 (95% confidence interval [CI], 47.9–53.8). RSV testing expanded considerably across the study period, with the testing in 2023 more than five times the 2017 total. The detection rate was highest in adults ≥60 years between 2017 and 2019, particularly those ≥75 years. Following 2020, the detections in all age groups increased, with the highest detection rate in 2023 in those ≥75-years (199.5 per 100,000; 95% CI, 180.5–220). NPIs significantly impacted RSV seasonality; the preceding winter pattern was disrupted, resulting in an absent 2020 winter season and two major summer seasons in 2020/21 and 2021/22. The RSV season began to realign in 2022, reverting to a winter seasonal pattern in 2023 and the largest season in the study period. Ongoing surveillance will be required to understand the stability of these increases and to delineate the impact of new immunisation strategies. Full article
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12 pages, 7880 KiB  
Article
A Proposal for Sediment Control Countermeasures in Non-Flowing Mountain Streams
by Norio Harada, Yoshifumi Satofuka and Takahisa Mizuyama
Water 2024, 16(9), 1197; https://doi.org/10.3390/w16091197 (registering DOI) - 23 Apr 2024
Abstract
In Japan, the heavy rain disaster that occurred in July 2018 revealed that about 70% of the streams affected by debris flows that resulted in human casualties were small, steep mountain streams with a catchment area < 0.05 km2. Generally, many [...] Read more.
In Japan, the heavy rain disaster that occurred in July 2018 revealed that about 70% of the streams affected by debris flows that resulted in human casualties were small, steep mountain streams with a catchment area < 0.05 km2. Generally, many streams that are close to residential houses or roads do not have a constant flow of water and are known to pose a high risk of human fatalities when a debris flow occurs. This study aimed to promote sediment control as debris flow countermeasures in non-flowing mountain streams, utilizing secondary manufactured products (permeable debris flow barriers) with excellent constructability, focusing on the mechanism of sediment outflow from the gaps between a permeable debris flow barrier and mountain stream side banks. The necessity and effectiveness of preventative measures based on preliminary experimental results are presented. When impermeable structures were installed at both ends of the permeable debris flow barrier side, compared to using only a permeable debris flow barrier (covering the entire width with permeable debris flow barriers), we found that the capture function improved significantly, achieving a 200% increase in effectiveness. Full article
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19 pages, 1076 KiB  
Review
Axillary Surgery for Breast Cancer in 2024
by Martin Heidinger and Walter P. Weber
Cancers 2024, 16(9), 1623; https://doi.org/10.3390/cancers16091623 (registering DOI) - 23 Apr 2024
Abstract
Axillary surgery for patients with breast cancer (BC) in 2024 is becoming increasingly specific, moving away from the previous ‘one size fits all’ radical approach. The goal is to spare morbidity whilst maintaining oncologic safety. In the upfront surgery setting, a first landmark [...] Read more.
Axillary surgery for patients with breast cancer (BC) in 2024 is becoming increasingly specific, moving away from the previous ‘one size fits all’ radical approach. The goal is to spare morbidity whilst maintaining oncologic safety. In the upfront surgery setting, a first landmark randomized controlled trial (RCT) on the omission of any surgical axillary staging in patients with unremarkable clinical examination and axillary ultrasound showed non-inferiority to sentinel lymph node (SLN) biopsy (SLNB). The study population consisted of 87.8% postmenopausal patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative BC. Patients with clinically node-negative breast cancer and up to two positive SLNs can safely be spared axillary dissection (ALND) even in the context of mastectomy or extranodal extension. In patients enrolled in the TAXIS trial, adjuvant systemic treatment was shown to be similar with or without ALND despite the loss of staging information. After neoadjuvant chemotherapy (NACT), targeted lymph node removal with or without SLNB showed a lower false-negative rate to determine nodal pathological complete response (pCR) compared to SLNB alone. However, oncologic outcomes do not appear to differ in patients with nodal pCR determined by either one of the two concepts, according to a recently published global, retrospective, real-world study. Real-world studies generally have a lower level of evidence than RCTs, but they are feasible quickly and with a large sample size. Another global real-world study provides evidence that even patients with residual isolated tumor cells can be safely spared from ALND. In general, few indications for ALND remain. Three randomized controlled trials are ongoing for patients with clinically node-positive BC in the upfront surgery setting and residual disease after NACT. Pending the results of these trials, ALND remains indicated in these patients. Full article
(This article belongs to the Special Issue Clinical Research and Progress in the Treatment of Breast Cancer)
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21 pages, 4111 KiB  
Article
Activin A, a Novel Chemokine, Induces Mouse NK Cell Migration via AKT and Calcium Signaling
by Yunfeng Wang, Zhonghui Liu, Yan Qi, Jiandong Wu, Boyang Liu and Xueling Cui
Cells 2024, 13(9), 728; https://doi.org/10.3390/cells13090728 (registering DOI) - 23 Apr 2024
Abstract
Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the migration of NK cells. Activin A, a member of the transforming growth factor β [...] Read more.
Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the migration of NK cells. Activin A, a member of the transforming growth factor β (TGF-β) superfamily, is highly expressed in tumor tissues and involved in tumor development and immune cell activation. In this study, we focus on the effects of activin A on NK cell migration. In vitro, activin A induced NK cell migration and invasion, promoted cell polarization and inhibited cell adhesion. Moreover, activin A increased Ca2+, p-SMAD3 and p-AKT levels in NK cells. An AKT inhibitor and Ca2+ chelator partially blocked activin A-induced NK cell migration. In vivo, exogenous activin A increased tumor-infiltrating NK cells in NS-1 cell solid tumors and inhibited tumor growth, and blocking endogenous activin A with anti-activin A antibody reduced tumor-infiltrating NK cells in 4T-1 cell solid tumors. These results suggest that activin A induces NK cell migration through AKT signaling and calcium signaling and may enhance the antitumor effect of NK cells by increasing tumor-infiltrating NK cells. Full article
(This article belongs to the Section Cellular Immunology)
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18 pages, 4868 KiB  
Article
Unraveling the Interactions between Lithium and Twisted Graphene
by Maximo Ramírez, Giorgio De Luca and Lorenzo Caputi
Materials 2024, 17(9), 1941; https://doi.org/10.3390/ma17091941 (registering DOI) - 23 Apr 2024
Abstract
Graphene is undoubtedly the carbon allotrope that has attracted the attention of a myriad of researchers in the last decades more than any other. The interaction of external or intercalated Li and Li+ with graphene layers has been the subject of particular [...] Read more.
Graphene is undoubtedly the carbon allotrope that has attracted the attention of a myriad of researchers in the last decades more than any other. The interaction of external or intercalated Li and Li+ with graphene layers has been the subject of particular attention for its importance in the applications of graphene layers in Lithium Batteries (LiBs). It is well known that lithium atoms and Li+ can be found inside and/or outside the double layer of graphene, and the graphene layers are often twisted around its parallel plane to obtain twisted graphene with tuneable properties. Thus, in this research, the interactions between Li and Li+ with bilayer graphene and twisted bilayer graphene were investigated by a first-principles density functional theory method, considering the lithium atom and the cation at different symmetry positions and with two different adsorption configurations. Binding energies and equilibrium interlayer distances of filled graphene layers were obtained from the computed potential energy profiles. This work shows that the twisting can regulate the interaction of bilayer graphene with Li and Li+. The binding energies of Li+ systematically increase from bilayer graphene to twisted graphene regardless of twisted angles, while for lithium atoms, the binding energies decrease or remain substantially unchanged depending on the twist angles. This suggests a higher adsorption capacity of twisted graphene towards Li+, which is important for designing twisted graphene-based material for LiB anode coating. Furthermore, when the Li or Li+ is intercalated between two graphene layers, the equilibrium interlayer distances in the twisted layers increase compared to the unrotated bilayer, and the relaxation is more significant for Li+ with respect to Li. This suggests that the twisted graphene can better accommodate the cation in agreement with the above result. The outcomes of this research pave the way for the study of the selective properties of twisted graphene. Full article
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14 pages, 1947 KiB  
Review
Nature-Inspired Micro/Nano-Structured Antibacterial Surfaces
by E Jin, Zhijun Lv, Yinghao Zhu, Hongmei Zhang and He Li
Molecules 2024, 29(9), 1906; https://doi.org/10.3390/molecules29091906 (registering DOI) - 23 Apr 2024
Abstract
The problem of bacterial resistance has become more and more common with improvements in health care. Worryingly, the misuse of antibiotics leads to an increase in bacterial multidrug resistance and the development of new antibiotics has virtually stalled. These challenges have prompted the [...] Read more.
The problem of bacterial resistance has become more and more common with improvements in health care. Worryingly, the misuse of antibiotics leads to an increase in bacterial multidrug resistance and the development of new antibiotics has virtually stalled. These challenges have prompted the need to combat bacterial infections with the use of radically different approaches. Taking lessons from the exciting properties of micro-/nano-natural-patterned surfaces, which can destroy cellular integrity, the construction of artificial surfaces to mimic natural functions provides new opportunities for the innovation and development of biomedicine. Due to the diversity of natural surfaces, functional surfaces inspired by natural surfaces have a wide range of applications in healthcare. Nature-inspired surface structures have emerged as an effective and durable strategy to prevent bacterial infection, opening a new way to alleviate the problem of bacterial drug resistance. The present situation of bactericidal and antifouling surfaces with natural and biomimetic micro-/nano-structures is briefly reviewed. In addition, these innovative nature-inspired methods are used to manufacture a variety of artificial surfaces to achieve extraordinary antibacterial properties. In particular, the physical antibacterial effect of nature-inspired surfaces and the functional mechanisms of chemical groups, small molecules, and ions are discussed, as well as the wide current and future applications of artificial biomimetic micro-/nano-surfaces. Current challenges and future development directions are also discussed at the end. In the future, controlling the use of micro-/nano-structures and their subsequent functions will lead to biomimetic surfaces offering great potential applications in biomedicine. Full article
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14 pages, 360 KiB  
Article
Metalinguistic Commentary on Forms of Address in a Finnish Autobiographical Novel Series
by Hanna Lappalainen and Maija Saviniemi
Languages 2024, 9(5), 153; https://doi.org/10.3390/languages9050153 (registering DOI) - 23 Apr 2024
Abstract
This article examines the metalinguistic commentary on address practices in a Finnish autobiographical novel series, the 26-volume Iijoki-sarja ‘Iijoki Series’ (1971–1998) by Kalle Päätalo. Our aim is to show how the forms of address affect the protagonist and other characters. The study is [...] Read more.
This article examines the metalinguistic commentary on address practices in a Finnish autobiographical novel series, the 26-volume Iijoki-sarja ‘Iijoki Series’ (1971–1998) by Kalle Päätalo. Our aim is to show how the forms of address affect the protagonist and other characters. The study is anchored in previous sociopragmatic research on address and in folk linguistics. The analysis is based on searches in the digital corpus of the whole series by means of keywords related to forms of address. The analysis proceeds chronologically, from Kalle’s childhood and adolescence to his marriage and working life, including his social rise from a poor country boy to a full-time novel writer. Our results show that Kalle, the fictional protagonist of the series, mirrors his own and others’ choices in address practices throughout his life against the norms he has learned in his childhood. These choices are explained by the (relative) age, sex, status and regional background of the interlocutors. Metalinguistic comments reflect the characters’ social relations and changes in them during the protagonist’s linguistic biography. We argue that fiction can open up perceptions and contexts related to address practices that are not easily accessible by other methods or datasets. Full article
(This article belongs to the Special Issue Perception and Processing of Address Terms)
28 pages, 6294 KiB  
Article
A Comparative Study of the Antiemetic Effects of α2-Adrenergic Receptor Agonists Clonidine and Dexmedetomidine against Diverse Emetogens in the Least Shrew (Cryptotis parva) Model of Emesis
by Yina Sun and Nissar A. Darmani
Int. J. Mol. Sci. 2024, 25(9), 4603; https://doi.org/10.3390/ijms25094603 (registering DOI) - 23 Apr 2024
Abstract
In contrast to cats and dogs, here we report that the α2-adrenergic receptor antagonist yohimbine is emetic and corresponding agonists clonidine and dexmedetomidine behave as antiemetics in the least shrew model of vomiting. Yohimbine (0, 0.5, 0.75, 1, 1.5, 2, and [...] Read more.
In contrast to cats and dogs, here we report that the α2-adrenergic receptor antagonist yohimbine is emetic and corresponding agonists clonidine and dexmedetomidine behave as antiemetics in the least shrew model of vomiting. Yohimbine (0, 0.5, 0.75, 1, 1.5, 2, and 3 mg/kg, i.p.) caused vomiting in shrews in a bell-shaped and dose-dependent manner, with a maximum frequency (0.85 ± 0.22) at 1 mg/kg, which was accompanied by a key central contribution as indicated by increased expression of c-fos, serotonin and substance P release in the shrew brainstem emetic nuclei. Our comparative study in shrews demonstrates that clonidine (0, 0.1, 1, 5, and 10 mg/kg, i.p.) and dexmedetomidine (0, 0.01, 0.05, and 0.1 mg/kg, i.p.) not only suppress yohimbine (1 mg/kg, i.p.)-evoked vomiting in a dose-dependent manner, but also display broad-spectrum antiemetic effects against diverse well-known emetogens, including 2-Methyl-5-HT, GR73632, McN-A-343, quinpirole, FPL64176, SR141716A, thapsigargin, rolipram, and ZD7288. The antiemetic inhibitory ID50 values of dexmedetomidine against the evoked emetogens are much lower than those of clonidine. At its antiemetic doses, clonidine decreased shrews’ locomotor activity parameters (distance moved and rearing), whereas dexmedetomidine did not do so. The results suggest that dexmedetomidine represents a better candidate for antiemetic potential with advantages over clonidine. Full article
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17 pages, 7003 KiB  
Article
Stability and Failure of Thin-Walled Composite Plate Elements with Asymmetric Configurations
by Katarzyna Falkowicz
Materials 2024, 17(9), 1943; https://doi.org/10.3390/ma17091943 (registering DOI) - 23 Apr 2024
Abstract
In the present study, the stability and failure phenomena of thin-walled constructions subjected to axial compression, featuring a central cut-out, and constructed from composite materials were explored. These constructions were fabricated from a carbon–epoxy composite using the autoclave method. The research encompassed experimental [...] Read more.
In the present study, the stability and failure phenomena of thin-walled constructions subjected to axial compression, featuring a central cut-out, and constructed from composite materials were explored. These constructions were fabricated from a carbon–epoxy composite using the autoclave method. The research encompassed experimental assessments on actual specimens alongside numerical analyses employing the finite element approach within the ABAQUS® software. The investigation spanned the entire load spectrum up to the point of structural failure, incorporating both practical trials and simulation analysis. During the practical assessments, the study monitored the post-buckling response and captured acoustic emissions to thoroughly evaluate the composite’s failure mechanisms. Additionally, the ARAMIS system’s non-invasive three-dimensional scanning was employed to assess deformations. Theoretical simulations utilized a step-by-step failure analysis, initiating with failure onset as per Hashin’s theory and proceeding to failure progression based on an energy criterion. The simulation outcomes, particularly concerning the critical and post-critical phases, were juxtaposed with empirical data to identify the composite’s vulnerability zones. The comparison underscored a significant concordance between the simulation predictions and the empirical findings. Full article
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10 pages, 208 KiB  
Article
Intellectual Humility and the Argument from Evil: A Reply to Zain Ali
by John Bishop and Ken Perszyk
Religions 2024, 15(5), 522; https://doi.org/10.3390/rel15050522 (registering DOI) - 23 Apr 2024
Abstract
This is a response to Zain Ali’s critique in this journal of our presentation of a ‘right relationship’ normatively relativised ‘logical’ Argument from Evil. Our argument aims to show that the existence of horrendous evils (as defined by Marilyn Adams) is incompatible with [...] Read more.
This is a response to Zain Ali’s critique in this journal of our presentation of a ‘right relationship’ normatively relativised ‘logical’ Argument from Evil. Our argument aims to show that the existence of horrendous evils (as defined by Marilyn Adams) is incompatible with the existence of the personal omniGod (a person or personal being who is all-powerful, all-knowing, and perfectly good), given certain reasonable judgments about what a personal God’s perfect goodness would imply about the way God relates to those caught up in horrendous evils. We reply to Ali’s main criticism that our assumptions about divine goodness are unjustified, and show a lack of intellectual humility. We defend the claim that, if God is a person, then God’s goodness is moral goodness according to our best human theory of what that implies. We accept that God’s situation as creator and sustainer of all that exists may justify ‘divine exceptionalism’: God’s personal moral goodness may be consistent with ways of relating to others that would fall far short of perfection in human-to-human relationships. But in that case, we argue, intellectual humility may be better served by accepting that God is so exceptional that God should not be understood as a person at all, which is the prevailing Muslim view, as Ali himself acknowledges. Full article
(This article belongs to the Special Issue Problems in Contemporary Islamic Philosophy of Religion)
34 pages, 9496 KiB  
Article
Telemetry System to Monitor Elastic Torque on Rolling Stand Spindles
by Stanislav S. Voronin, Boris M. Loginov, Olga A. Gasiyarova, Sergey A. Evdokimov, Alexander S. Karandaev and Vadim R. Khramshin
J. Manuf. Mater. Process. 2024, 8(3), 85; https://doi.org/10.3390/jmmp8030085 (registering DOI) - 23 Apr 2024
Abstract
This article outlines the relevance of building online telemetry systems for online monitoring of the technical conditions of rolling mill equipment. Electromechanical systems of the horizontal stand of the plate Mill 5000 are described, when operating in harsh conditions caused by the shock [...] Read more.
This article outlines the relevance of building online telemetry systems for online monitoring of the technical conditions of rolling mill equipment. Electromechanical systems of the horizontal stand of the plate Mill 5000 are described, when operating in harsh conditions caused by the shock loading when workpieces enter the stand. It is noted that dynamic torque overloads, exceeding the rated motor torque by many-fold, cause the fatigue failure of spindle joints and breakage of rolls. In this regard, the development and implementation of systems for monitoring the elastic torque on spindles are extremely urgent. This issue has long been studied, but the references provide no information on the building principles and hardware composition of such systems. The use of strain gauges connected according to a balanced bridge circuit to measure the elastic torque is justified. This paper’s contribution is the proposed modular principle for building a telemetry monitoring system based on the analysis of known techniques for measuring and transmitting diagnostic data. The developed system structure is provided and the concept of data transfer and processing are explained. This article suggests the inductive power supply of a measuring unit mounted on a shaft without the use of batteries. A hardware structure was developed to be applied in a system for measuring, transmitting, and visualizing signals proportional to the elastic torque, manufactured on the basis of data measuring instruments by leading companies. The specifics of placement and connection of strain gauges are considered. The hardware providing a wireless power supply to the signal encoder and digital data transfer between the transmitter and receiver is described. The results of implementing the system on Mill 5000 are provided. The installation of a telemetry ring and a receiving head for the inductive power supply and data reception is shown. An experimental assessment of the elastic torques occurring when workpieces enter the cage was obtained by implementing a drive control algorithm which provided biting in the drive acceleration mode. The reliability of measuring the elastic torque with an error not exceeding ±5% and the reduction of dynamic loads on the spindle by 1.3–1.5 times due to the elimination of impacts from closing angular gaps in spindle joints was confirmed. This increases the service life of mechanical equipment and reduces the cost of eliminating the accident aftermath. The prospect of modifying the developed system into a cyber-physical system for monitoring the rolling mill’s mechatronic equipment conditions is shown. Full article
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21 pages, 10505 KiB  
Article
Cellular Response of Adapted and Non-Adapted Tetrahymena thermophila Strains to Europium Eu(III) Compounds
by Patricia Alonso, Javier Blas, Francisco Amaro, Patricia de Francisco, Ana Martín-González and Juan Carlos Gutiérrez
Biology 2024, 13(5), 285; https://doi.org/10.3390/biology13050285 (registering DOI) - 23 Apr 2024
Abstract
Europium is one of the most reactive lanthanides and humans use it in many different applications, but we still know little about its potential toxicity and cellular response to its exposure. Two strains of the eukaryotic microorganism model Tetrahymena thermophila were adapted to [...] Read more.
Europium is one of the most reactive lanthanides and humans use it in many different applications, but we still know little about its potential toxicity and cellular response to its exposure. Two strains of the eukaryotic microorganism model Tetrahymena thermophila were adapted to high concentrations of two Eu(III) compounds (EuCl3 or Eu2O3) and compared to a control strain and cultures treated with both compounds. In this ciliate, EuCl3 is more toxic than Eu2O3. LC50 values show that this microorganism is more resistant to these Eu(III) compounds than other microorganisms. Oxidative stress originated mainly by Eu2O3 is minimized by overexpression of genes encoding important antioxidant enzymes. The overexpression of metallothionein genes under treatment with Eu(III) compounds supports the possibility that this lanthanide may interact with the -SH groups of the cysteine residues from metallothioneins and/or displace essential cations of these proteins during their homeostatic function. Both lipid metabolism (lipid droplets fusing with europium-containing vacuoles) and autophagy are involved in the cellular response to europium stress. Bioaccumulation, together with a possible biomineralization to europium phosphate, seems to be the main mechanism of Eu(III) detoxification in these cells. Full article
(This article belongs to the Collection Feature Papers in Microbial Biology)
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11 pages, 528 KiB  
Article
Self-Control, Openness, Personal Need for Structure and Compensatory Control Change: A Serial Mediation Investigation
by Yuan Zhao, Yuying Wang, Liuqing Wei, Yu Ma, Yunyun Chen and Xuemin Zhang
Behav. Sci. 2024, 14(5), 352; https://doi.org/10.3390/bs14050352 (registering DOI) - 23 Apr 2024
Abstract
In the aftermath of the COVID-19 pandemic, numerous studies have indicated that individuals are confronting a diminished sense of control. Compensatory control theory suggests that individuals strive to mitigate this loss by modifying their behavior. The present study aims to investigate the relationship [...] Read more.
In the aftermath of the COVID-19 pandemic, numerous studies have indicated that individuals are confronting a diminished sense of control. Compensatory control theory suggests that individuals strive to mitigate this loss by modifying their behavior. The present study aims to investigate the relationship between self-control and compensatory control change during the COVID-19 pandemic, as well as the mediating effects of openness and the personal need for structure. Participants completed an online questionnaire consisting of Personal Need for Structure Scale, Self-Control Scale, Openness Scale and Compensatory Control Change Scale. The results showed that the compensatory control change increased after the outbreak. Moreover, a serial mediation was found: openness and the personal need for structure partially mediated the relationship between self-control and compensatory control change. The results indicate that the COVID-19 pandemic has led to an increase in compensatory control behaviors, especially among those with pronounced self-control. High self-control individuals are found to exhibit greater openness, reducing their personal need for structure, in effect enhancing their compensatory control change. These findings highlight the critical role of self-control in sustaining a sense of control, which is vital for understanding psychological health management in the context of public health events. Full article
(This article belongs to the Section Social Psychology)
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20 pages, 3610 KiB  
Article
Research on Complex Network Models and Characteristics of Building Material Enterprises Based on Competitive Relationships
by Likun Zhao, Hui Yuan, Mengqian An and Xiaoqing Bao
Buildings 2024, 14(5), 1192; https://doi.org/10.3390/buildings14051192 (registering DOI) - 23 Apr 2024
Abstract
Based on complex network theory, this paper establishes a Boolean competitive relationship network model and a weighted competitive relationship network model for building material enterprises based on big data and performs empirical analyses with construction prefabricated component (PC) enterprises in the Beijing–Tianjin–Hebei region [...] Read more.
Based on complex network theory, this paper establishes a Boolean competitive relationship network model and a weighted competitive relationship network model for building material enterprises based on big data and performs empirical analyses with construction prefabricated component (PC) enterprises in the Beijing–Tianjin–Hebei region as research samples. Results show the competitive relationship network of PC enterprises in the Beijing–Tianjin–Hebei region is characterised by the development of a small-world network, and its cumulative degree and out-degree (in-degree) intensity distributions are single-scale networks with fast-decaying tails. The network has strong network clustering and assortativity, and it can truly reflect the competitive status and dynamics of the enterprises. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
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