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  • Mice  (112)
  • Dose-Response Relationship, Drug  (59)
  • Cats  (37)
  • American Association for the Advancement of Science (AAAS)  (197)
  • Nature Publishing Group
  • 1975-1979  (197)
  • 1940-1944
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (197)
  • Nature Publishing Group
  • Springer  (10)
Years
Year
  • 1
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    Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ballou, B -- Levine, G -- Hakala, T R -- Solter, D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):844-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Neoplasm ; Clone Cells/immunology ; Mice ; Neoplasms, Experimental/diagnosis/immunology ; Radionuclide Imaging/*methods ; Teratoma/*diagnosis/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Pituitary-brain vascular relations: a new paradigm (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Vascular casts of the pituitary gland have demonstrated a paucity of veins extending from the adenohypophysis to the systemic circulation and have suggested that some adenohypophyseal venous blood returns to the neurohypophysis. The neurohypophyseal capillary bed may function as a vascular switch and in this article a series of 14 questions are proposed regarding the vascular dynamics of the pituitary. Together these questions raise the larger question, namely, whether pituitary hormones are transported directly to the brain to modify brain function?〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergland, R M -- Page, R B -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriovenous Anastomosis/anatomy & histology ; Capillaries/anatomy & histology ; Cats ; *Cerebrovascular Circulation ; Dogs ; Humans ; Hypothalamo-Hypophyseal System/blood supply ; Pituitary Gland/*blood supply ; Pituitary Gland, Anterior/blood supply ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Obesity genes: beneficial effects in heterozygous mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity-diabetes states in homozygotes. These obesity syndromes are characterized by a more efficient conversion of food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, either ob/+ or db/+, survived a prolonged fast significantly longer than normal homozygotes (+/+); this suggests that the heterozygotes exhibited increased metabolic efficiency, a feature normally associated with both homozygous mutants. The existence of this thriftiness trait, if manifested by heterozygous carriers in wild populations, would lend credence to the thrifty gene concept of diabetes. Beneficial effects of normally deleterious genes may have played a role in the development of diabetes-susceptible human populations, as well as having provided the survival advantage that has allowed both the development and successful establishment of species in desert and other less affluent regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coleman, D L -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):663-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760211" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Temperature Regulation ; Diabetes Mellitus, Experimental/*genetics/metabolism ; Fasting ; Glucose/metabolism ; Heterozygote ; Insulin/blood ; Mice ; Mice, Obese/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 4
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    Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a synergistic effect on the number of cells killed in culture. Methotrexate dose-related increases occur in the concentrations of intracellular 5-fluorouracil ribonucleotides and 5-fluoro-2'-deoxyuridylate and in the incorporation of 5-fluorouracil into RNA. These increases are correlated with increased concentrations of intracellular phosphoribosylpyrophosphate. It is proposed that the enhanced formation of ribonucleotides of 5-fluorouracil and the subsequent incorporation of these compounds into RNA in methotrexate-treated cells may account for synergism between these agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cadman, E -- Heimer, R -- Davis, L -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Drug Administration Schedule ; Drug Synergism ; Fluorouracil/metabolism/*pharmacology ; Leukemia L1210 ; Methotrexate/*pharmacology ; Mice ; Phosphoribosyl Pyrophosphate/metabolism ; RNA, Neoplasm/metabolism ; Ribonucleotides/metabolism ; Thymidylate Synthase/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Seaweed dermatitis: structure of lyngbyatoxin A (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: A highly inflammatory and vesicatory substance, lyngbyatoxin A, has been isolated from the lipid extract of a Hawaiian shallow-water variety of Lyngbya majuscula Gomont; its gross structure was determined from chemical and spectral data. Lyngbyatoxin A is closely related to teleocidin B, a poisonous substance associated with several strains of Streptomyces.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cardellina, J H 2nd -- Marner, F J -- Moore, R E -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107586" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaloids/*toxicity ; Animals ; *Cyanobacteria ; Dermatitis, Contact/*etiology ; *Dermotoxins ; Indoles/toxicity ; *Marine Toxins ; Mice
    Print ISSN: 0036-8075
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  • 6
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    Visual resolution and receptive field size: examination of two kinds of cat retinal ganglion cell (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: Intraocular recordings from brisk-sustained and brisk-transient ganglion cells in the cat's retina revealed a systematic increase in center size and decrease in spatial cut-off frequency with increasing distance from the area centralis. At any one eccentricity sizes of the centers of sustained and transient cells did not overlap, and the variation in cut-off frequency for each class was constrained to about one-half octave.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cleland, B G -- Harding, T H -- Tulunay-Keesey, U -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1015-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472720" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Evoked Potentials ; Ganglia/physiology ; Retina/cytology/*physiology ; Vision, Ocular/*physiology ; *Visual Fields
    Print ISSN: 0036-8075
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  • 7
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    Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Micropipettes containing 2 to 50 biological units of beta growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gundersen, R W -- Barrett, J N -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1079-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/growth & development/*physiology ; Cells, Cultured ; *Chemotaxis/drug effects ; Chick Embryo ; Dose-Response Relationship, Drug ; Ganglia, Spinal/physiology ; Nerve Growth Factors/*pharmacology
    Print ISSN: 0036-8075
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  • 8
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    Structure of physiologically identified X and Y cells in the cat's lateral geniculate nucleus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Horseradish peroxidase injected into 18 single, physiologically identified geniculate X and Y cells permitted a detailed morphological correlate to be determined for the physiological properties of each neuron. Class 1 morphological characteristics were associated with Y cells, class 3 with X cells, and class 2 structural traits were seen in both physiological types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedlander, M J -- Lin, C S -- Sherman, S M -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1114-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451559" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Geniculate Bodies/*cytology/physiology ; Horseradish Peroxidase ; Interneurons/cytology
    Print ISSN: 0036-8075
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  • 9
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    Cortical plasticity in monocularly deprived immobilized kittens depends on eye movement (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: A marked reduction of binocular cells in striate cortex is found if 4-week-old kittens are visually stimulated monocularly while anesthetized and held in a stereotaxic apparatus. If the kittens are paralyzed and artificially respirated, changes are not found unless an eye is moved mechanically. It appears that eye movement and visual stimulation are necessary conditions for deactivation of binocular connections, but neither is sufficient to induce such changes alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freeman, R D -- Bonds, A B -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1093-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Evoked Potentials ; *Eye Movements ; Functional Laterality ; Immobilization ; Paralysis/physiopathology ; Visual Cortex/*growth & development/physiology ; Visual Pathways/*growth & development
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Cytidylate cyclase: possible artifacts in the methodology (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaion, R M -- Krishna, G -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):672-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytosine Nucleotides ; Liver/*enzymology ; Lyases/*metabolism ; Mice
    Print ISSN: 0036-8075
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  • 11
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    Muscle fiber regeneration after transplantation: prediction of structure and physiology from electromyograms (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Digitized electromyographic activity of transplanted extensor digitorum longus (EDL) muscles in cats differs from that of control EDL and anterior tibialis muscles lying adjacent to transplanted EDL muscles. In autotransplanted muscles, the cross-sectional area of the fibers shows a negative correlation with mean spike frequency and a positive correlation with mean amplitude. The mean frequency-amplitude products correlate with isometric tetanic tensions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorniak, G C -- Gans, C -- Faulkner, J A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1085-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451552" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Electrodes ; Electromyography/methods ; Muscles/cytology/physiology/*transplantation ; *Regeneration ; Transplantation, Autologous
    Print ISSN: 0036-8075
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  • 12
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    Alteration of cortical orientation selectivity: importance of asymmetric input (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Rearing cats so that each of the two eyes sees stripes of a different orientation alters the orientation preference of visual cortex cells. This result can be obtained by rearing the cats in striped cylinders or with goggles attached to their faces, but a tighter control of orientation preference is achieved by the goggles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordon, B -- Presson, J -- Packwood, J -- Scheer, R -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1109-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451557" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Functional Laterality ; Orientation/*physiology ; Visual Cortex/cytology/*growth & development/physiology ; Visual Perception/*physiology
    Print ISSN: 0036-8075
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  • 13
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    Effect of beta-endorphin on calcium uptake in the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero-Munoz, F -- de Lourdes Guerrero, M -- Way, E L -- Li, C H -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Dose-Response Relationship, Drug ; Drug Tolerance ; Endorphins/antagonists & inhibitors/*pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Neurotransmitter Agents/metabolism ; Rats ; Synaptosomes/*drug effects/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lymphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, L C -- Flier, J -- Itin, A -- Kahn, C R -- Roth, J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):544-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Binding Sites ; Binding Sites, Antibody ; Epitopes ; Female ; Humans ; Liver/analysis ; Lymphocytes/analysis ; Mice ; Placenta/analysis ; Pregnancy ; Radioimmunoassay/methods ; Receptor, Insulin/analysis/*immunology ; Solubility
    Print ISSN: 0036-8075
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  • 15
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    Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: The genetic linkage of the endogenous C3H/HeJ C-type ecotropic virus to phosphoglucomutase-1 (0.28, recombinant fraction) on chromosome 5 was established by means of serological assays of backcrossed mice. With a combination of serological techniques and DNA-DNA hybridization the BALB/c endogenous ecotropic virus was shown to be either closely linked or allelic with the C3H/HeJ locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ihle, J N -- Joseph, D R -- Domotor, J J Jr -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219476" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Genes ; *Genes, Viral ; Genetic Linkage ; Leukemia Virus, Murine/genetics ; Mice ; Mice, Inbred BALB C/*microbiology ; Mice, Inbred C3H/*microbiology ; Mice, Inbred Strains/genetics ; Phenotype ; Phosphoglucomutase/*genetics ; Retroviridae/*genetics
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  • 16
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    Tissue perfusion rate determined from the decay of oxygen-15 activity after photon activation in situ (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: Rates of cerebral perfusion were obtained from measurements of the disappearance (wash-out) of oxygen-15 after in situ tissue activation with 45-million-volt x-rays. In an anesthetized cat, typical values were 90 milliliters per minute per 100 grams of tissue, with 55 percent wash-out. In a specific radiotherapy patient, the value was 65 milliliters per minute per 100 grams of tissue, with 63 percent wash-out of oxygen-15 through incorporation into tissue water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, W L -- Nussbaum, G H -- Connolly, R -- Emami, B -- Reilly, P -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451567" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Cats ; Humans ; Neoplasms/blood supply ; Oxygen/*blood/radiation effects ; Oxygen Radioisotopes ; *Regional Blood Flow ; X-Rays
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  • 17
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
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  • 18
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    Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
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    New drugs and the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):774-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/379998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; France ; History, 20th Century ; Humans ; Mice ; Psychotropic Drugs/*history/metabolism/therapeutic use ; Rats ; Schizophrenia/drug therapy ; United States
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  • 20
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    Lateral geniculate nucleus in dark-reared cats: loss of Y cells without changes in cell size (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-30
    Description: In cats reared in the dark from birth until 4 months of age, the dorsal lateral geniculate nucleus contained few normal Y cells in either the binocular or monocular segments. Although most of the neurons appeared to be normal X cells unaffected by light deprivation, many cells with abnormal receptive field and response charcteristics were encountered. These effects were permanent, since 1 to 2 years of normal visual experience following initial light deprivation did not lead to any functional recovery. The sizes of cell bodies in cats reared in the dark were similar to those of normal animals, an indication that changes in geniculate cell physiology need not be related to changes in cell size.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kratz, K E -- Sherman, S M -- Kalil, R -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1353-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Darkness ; Functional Laterality ; Geniculate Bodies/*cytology/growth & development ; *Vision, Ocular ; Visual Pathways/cytology/*growth & development
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  • 21
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    Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic murine leukemia virus in BALB/c mice, was mapped to chromosome 5, 23 units from the locus for phosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozak, C A -- Rowe, W P -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219475" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Genes, Viral ; Genetic Linkage ; Hybrid Cells/microbiology ; Leukemia Virus, Murine/*genetics ; Mice ; Mice, Inbred BALB C/*microbiology ; Phosphoglucomutase/metabolism ; Virus Replication
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  • 22
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    Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Crabtree, R E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382359" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Ergolines/*pharmacology/therapeutic use ; Humans ; Informed Consent ; Male ; Middle Aged ; Placebos ; Prolactin/blood ; Receptors, Dopamine/*drug effects ; Time Factors
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  • 23
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    Angiogenesis in the mouse cornea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: We have developed a method that permits analysis of neovascular responses in the mouse cornea. Using this method we have demonstrated that both allogeneic lymphocytes and a variety of tumors can induce angiogenesis, but that only the latter appear capable of eliciting secondary capillary sprouting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muthukkaruppan, V -- Auerbach, R -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472760" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cornea/*blood supply ; In Vitro Techniques ; Mice ; Mice, Inbred Strains ; Microcirculation ; Neoplasms, Experimental/*blood supply
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  • 24
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    Drug safety: phenacetin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklin, A W -- Welch, R M -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):144, 146, 148.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451584" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens ; Liver Neoplasms/*chemically induced ; Mice ; Neoplasms, Experimental/chemically induced ; Phenacetin/*adverse effects/standards ; Rats
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  • 25
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    Reversal potential for noradrenaline-induced hyperpolarization of spinal motoneurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: By using two separate electrodes with tips inside a single feline motoneuron, current-voltage characteristics were studied during extracellular iontophoresis of noradrenaline. The usually observed hyperpolarization was accompanied by an increase in membrane resistance and became larger with polarizing and smaller with depolarizing currents. During large depolarizing current injections, the noradrenaline-induced potential reversed its direction, usually at a membrane potential of about -20 millivolts. These data are compatible with the concept that noradrenaline hyperpolarizes nerve cells by decreasing resting membrane conductances to sodium and potassium ions. The observation could also be explained by a nonspecific decrease in ion permeability that is associated with a hyperpolarization due to sodium pump activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, K C -- Engberg, I -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):422-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451613" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Membrane Potentials/drug effects ; Neurons/drug effects/*physiology ; Norepinephrine/*pharmacology ; Potassium/metabolism ; Sodium/metabolism ; Spinal Cord/drug effects/*physiology
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    Octopamine receptors, adenosine 3',5'-monophosphate, and neural control of firefly flashing (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-05
    Description: An adenylate cyclase activated as much as 25-fold by low concentrations of octopamine has been identified in the firefly lantern. The relative potency of octopamine and various other amines in stimulating this enzyme, and effects of antagonists in blocking octopamine activation, correlate well with the known effects of these agents in affecting light production. In addition to suggesting a role for adenosine 3',5'-monophosphate (or pyrophosphate) in the neural control of firefly flashing, identification of this potent enzyme should facilitate the characterization of phenylethylamine receptors in excitable tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, J A -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):65-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214856" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Beetles/*physiology ; Catecholamines/pharmacology ; Cyclic AMP/*biosynthesis ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Kinetics ; Octopamine/*pharmacology ; Phentolamine/pharmacology ; Propranolol/pharmacology ; Receptors, Cell Surface/*drug effects ; Receptors, Neurotransmitter/*drug effects ; Structure-Activity Relationship
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    Functional organization of lateral geniculate cells following removal of visual cortex in the newborn kitten (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: When the visual cortex of a newborn kitten is removed, most neurons in the dorsal lateral geniculate nucleus degenerate, but a small population of large cells is spared. Electrophysiological recording revealed that detailed visual topography in the nucleus is abnormal and that single cells have unusually large receptive fields. These results suggest that optic axons deprived of their normal synaptic targets rearrange their connections to converge on local surviving neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, E H -- Kalil, R -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):713-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493978" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/anatomy & histology ; Cats ; Functional Laterality ; Geniculate Bodies/*cytology ; Nerve Degeneration ; Visual Cortex/*cytology ; Visual Pathways/*cytology/growth & development
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    Nitrite promotes lymphoma incidence in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-08
    Description: Rats were exposed to sodium nitrite in food or water at concentrations of 0, 250, 1000, and 2000 parts per million. Lymphoma was increased in all groups fed nitrite; the overall combined incidence was 5.4 percent in 573 control rats and 10.2 percent in 1383 treated rats. The mechanism of cancer induction did not appear to be through the formation of nitrosamines but through a more direct effect of nitrite on the lymphocyte.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newberne, P M -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1079-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Lymphocytes/drug effects ; Lymphoma/*chemically induced ; Neoplasms, Experimental/chemically induced ; *Nitrites/pharmacology ; Rats
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  • 29
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    Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Mice with the mutant gene tottering (tg, chromosome 8, autosomal recessive) show, in adolescence, abnormal bursts of bilaterally synchronous spike waves as revealed in electrocorticograms recorded over long periods. The spike waves are accompanied by behavioral "absence" attacks and intermittent focal motor seizures showing somatotopic progression. Cerebral metabolic activity during seizures was assayed by autoradiography of brain sections from mice injected intravenously with 14C-labeled 2-deoxyglucose. Metabolic activity was increased bilaterally in selected brainstem structures. Spontaneous electrocorticographic and clinical seizures of this general pattern were recognized hitherto only in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noebels, J L -- Sidman, R L -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1334-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572084" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Behavior/*physiology ; Brain/growth & development/physiopathology ; Electrocardiography ; Epilepsy/*genetics/physiopathology ; Humans ; Mice ; Mice, Neurologic Mutants/genetics/*physiology ; Neural Pathways/physiopathology ; Seizures/physiopathology ; Stereotyped Behavior/*physiology
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    Methylation of mouse liver DNA studied by means of the restriction enzymes msp I and hpa II (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: The restriction enzymes Hpa II and Msp I both recognize the sequence 5'-CCGG (C, cytosine; G, guanine). However, Hpa II cuts mouse liver DNA to fragments four times larger than does Msp I. The size of DNA cut by Msp I is close to that predicted from base composition and nearest neighbor analysis. The most probable explanation of these results is that in mouse the site 5'-CCGG is highly methylated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singer, J -- Roberts-Ems, J -- Riggs, A D -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1019-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424726" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/*metabolism ; DNA (Cytosine-5-)-Methyltransferase/metabolism ; DNA Restriction Enzymes/metabolism ; Liver/metabolism ; Methylation ; Mice ; Molecular Weight ; Substrate Specificity
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    Drug discrimination training with progressively lowered doses (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-17
    Description: Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Overton, D A -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):720-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlordiazepoxide/pharmacology ; Cyclazocine/pharmacology ; Discrimination Learning/*physiology ; Dose-Response Relationship, Drug ; Fentanyl/pharmacology ; *Pharmacology ; Phenobarbital/pharmacology ; Rats ; Scopolamine Hydrobromide/pharmacology
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    NCI bioassays yield a trail of blunders (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1287-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay/methods ; *Carcinogens ; Legislation as Topic ; Mice ; *National Institutes of Health (U.S.) ; Research Design/standards ; Research Support as Topic ; United States
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  • 33
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    Microwave radiation and chlordiazepoxide: synergistic effects on fixed-interval behavior (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-30
    Description: In the presence of low-intensity pulsed microwave radiation, at an average power density of 1 milliwatt per square centimeter, the response-rate-increasing effects of chlordiazepoxide were potentiated in rats. The behavioral effects of a drug can be modified by brief exposure to a low-level microwave field even when the radiation level alone has no apparent effects on the behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, J R -- Burch, L S -- Yeandle, S S -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1357-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424759" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects/*radiation effects ; Chlordiazepoxide/*pharmacology ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Male ; *Microwaves ; Rats
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  • 34
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    Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-20
    Description: The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sweeny, G D -- Jones, K G -- Cole, F M -- Basford, D -- Krestynski, F -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):332-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432648" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dioxins/*toxicity ; Enzyme Induction ; Iron/*deficiency ; Liver/pathology ; Mice ; Microsomes, Liver/enzymology ; Mixed Function Oxygenases/metabolism ; Porphyrias/*chemically induced ; Tetrachlorodibenzodioxin/*toxicity ; Uroporphyrinogen Decarboxylase/metabolism
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  • 35
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    Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
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  • 36
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    Nickel carbonyl: prenatal exposure (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warner, J S -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1194-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424746" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Ketones/*toxicity ; Nickel/*toxicity ; Occupational Medicine ; Pregnancy ; Rats ; *Teratogens
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    Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The decrease in resting oxygen consumption induced by starvation was found to occur not only in euthyroid rats but also in hypothyroid and even in hypothyroid animals treated with triiodothyronine. Furthermore, the effectiveness of triiodothyronine was decreased when given to hypothyroid animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimpfheimer, C -- Saville, E -- Voirol, M J -- Danforth, E Jr -- Burger, A G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Energy Metabolism/drug effects ; Hypothyroidism/metabolism ; Male ; Oxygen Consumption/*drug effects ; Rats ; Receptors, Cell Surface/drug effects ; Starvation/*metabolism ; Triiodothyronine/*pharmacology
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  • 38
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    Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yotti, L P -- Chang, C C -- Trosko, J E -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493994" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication/*drug effects ; Cell Membrane/drug effects ; Cricetinae ; Dose-Response Relationship, Drug ; Drug Resistance ; Phorbol Esters/*pharmacology ; Phorbols/*pharmacology ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate/pharmacology ; Thioguanine/pharmacology
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  • 39
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    Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
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  • 40
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    Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatvin, M B -- Clifton, K H -- Dennis, W H -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):195-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451588" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/therapy ; Anesthetics, Local/*therapeutic use ; Animals ; Female ; *Hot Temperature ; Lidocaine/therapeutic use ; Mammary Neoplasms, Experimental/therapy ; Membrane Fluidity/drug effects ; Mice ; Neoplasms, Experimental/*therapy
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  • 41
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    Role of nuclear size in cell growth initiation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Swiss 3T3 cells arrested in B0 (quiescent state) by reducing serum content of the medium all contain the same amount of DNA but vary in nuclear volume over approximately a twofold range. By use of flow microfluorimetry, scatterplots of nuclear volume versus DNA content were obtained in intervals after serum stimulation. The earliest cells to enter DNA synthesis were those with the largest nuclei, whereas cells with the smallest nuclei were among the latest. Regulation of cellular transit from G0 to the S phase was therefore, at least in part, deterministic, since all G0 cells did not have equal probabilities of entry into S at a given moment. All cells having the same nuclear volume did not initiate DNA synthesis at the same moment; therefore, factors other than nuclear volume must also influence this timing. Nuclear volume correlated with the maximum rate at which cells could enter S. The kinetic model of the cell cycle postulating a probabilistic event as solely responsible for entry into S thus appears too simple.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yen, A -- Pardee, A B -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Division ; Cell Nucleus/physiology/*ultrastructure ; Cells, Cultured/*physiology/ultrastructure ; Clone Cells/ultrastructure ; DNA/biosynthesis ; Mice
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  • 42
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    Sporozoite-induced malaria: therapeutic effects of glycolipids in liposomes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (Plasmodium berghei) in mice previously injected with sporozoites. Inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. Inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside GM1. Liposomes containing glycolipids did not inhibit infection transmitted by injecting blood containing erythrocytic stages of malaria. These results may have therapeutic implications in the treatment of malaria. Analysis of the mechanism of interference with the life cycle of malaria by liposomal glycolipids may yield information about the interactions of parasites with cellular membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alving, C R -- Schneider, I -- Swartz, G M Jr -- Steck, E A -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1142-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382358" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ceramides/therapeutic use ; Erythrocytes/parasitology ; Glycolipids/*therapeutic use ; Liposomes/therapeutic use ; Liver/parasitology ; Malaria/parasitology/*therapy ; Mice ; Plasmodium berghei ; Structure-Activity Relationship
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    Chemical carcinogens (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 16;203(4381):602-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens/administration & dosage ; Dose-Response Relationship, Drug ; Mice ; Mutagens ; Neoplasms, Experimental/chemically induced ; Rats ; Vinyl Chloride/*toxicity ; Vinyl Compounds/*toxicity
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  • 44
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    Delayed neurotoxicity of phenylphosphonothioate esters (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abou-Donia, M B -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):713-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxia/chemically induced ; Chickens ; Demyelinating Diseases/chemically induced ; Dose-Response Relationship, Drug ; Female ; Insecticides/*toxicity ; Nerve Degeneration ; *Neurotoxins ; *Organothiophosphorus Compounds ; Time Factors
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  • 45
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    Canine Babesia new to North America (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: A domestic dog residing in New England suffered a fatal febrile illness caused by a Babesia infection. The morphology of these intraerythrocytic protozoa and the range of hosts that could be infected experimentally suggested that the parasite was B. gibsoni. Although this tick-bourne disease is enzootic in wild and domestic Canidae in Africa and Asia, it appears to be new to the Americas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J F -- Magnarelli, L A -- Donner, C S -- Spielman, A -- Piesman, J -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1431-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthropod Vectors ; Babesia/classification/cytology ; Babesiosis/epidemiology/*parasitology/transmission ; Cricetinae ; Dog Diseases/*parasitology ; Dogs ; Erythrocytes/parasitology ; Mice ; United States
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  • 46
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    Yearly report on carcinogens could be a potent weapon in the war on cancer (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):525-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760203" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Dose-Response Relationship, Drug ; Government Agencies ; Humans ; Legislation, Drug ; Neoplasms/*prevention & control ; United States
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  • 47
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    Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Chloroxymorphamine, the 6beta-N,N-bis(2-chloroethyl) derivative of oxymorphone, is a potent nonequilibrium narcotic agonist in the longitudinal muscle preparation of guinea pig ileum. The corresponding naltrexone analog,chlornaltrexamine, is a potent nonequilibrium antagonist of morphine. These receptor sitedirected alkylating agents possess considerable potenial as pharmacologic and biochemical probes of apoid receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caruso, T P -- Takemori, A E -- Larson, D L -- Portoghese, P S -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):316-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86208" target="_blank"〉PubMed〈/a〉
    Keywords: *Alkylating Agents ; Animals ; Chlorambucil/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Guinea Pigs ; Hydromorphone/*analogs & derivatives ; In Vitro Techniques ; Morphine/pharmacology ; Naloxone/pharmacology ; Naltrexone/analogs & derivatives/pharmacology ; Nitrogen Mustard Compounds/*pharmacology ; Norepinephrine/pharmacology ; Oxymorphone/*analogs & derivatives/pharmacology ; Phenoxybenzamine/pharmacology ; Receptors, Opioid/*drug effects
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  • 48
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    Molecular cloning of polyoma virus DNA in Escherichia coli: lambda phage vector system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: The biological activity of recombinant phage and recombinant phage DNA containing monomeric or dimeric polyoma DNA inserts was examined in mice and cultured mouse cells. Recombinant preparations containing a single copy of viral DNA were invariably noninfectious; molecules containing a dimeric polyoma DNA insert were at least seven orders of magnitude less infectious than polyoma virions after parenteral inoculation. No infection was detected with any recombinant preparation after oral administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, H W -- Israel, M A -- Garon, C F -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):887-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217088" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Coliphages/*genetics ; DNA Restriction Enzymes/metabolism ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; Polyomavirus/*genetics ; Risk ; Tumor Virus Infections/*genetics ; Virus Replication
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  • 49
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    Chlorpromazine and its metabolites alter polymerization and gelation of actin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Hepatic hydroxylated metabolites of chlorpromazine (10(-5)M to 10(-4)M), a frequently used phenothiazine tranquilizer, produce solid gel formation with filamentous actin, but the less toxic chlorpromazine sulfoxide metabolite does not. At higher concentrations (5 x 10(-4)M) chlorpromazine inhibits actin polymerization. These dose-response relationships parallel the drug's hepatic toxicity in vivo and suggest that interactions between chloropromazine or chlorpromazine metabolites and actin could be an underlying mechanism of cell injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elias, E -- Boyer, J L -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1404-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/574316" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Chlorpromazine/*analogs & derivatives/*pharmacology ; Cytoskeleton/drug effects ; Dose-Response Relationship, Drug ; Gels ; Protein Binding/drug effects ; Rabbits ; Viscosity
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  • 50
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    Toxaphene, a complex mixture of polychloroterpenes and a major insecticide, is mutagenic (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: Toxaphene, the most widely used chlorinated insecticide, is mutagenic in the Salmonella test without requiring liver homogenate for activity. This insecticide is a complex mixture (more than 177 polychloroterpenes) with carcinogenic activity in rodents. Some but not all of the mutagenic components are easily separated from the insecticidal ingredients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hooper, N K -- Ames, B N -- Saleh, M A -- Casida, J E -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):591-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377495" target="_blank"〉PubMed〈/a〉
    Keywords: Dose-Response Relationship, Drug ; Insecticides/*pharmacology ; *Mutagens ; Mutation ; Salmonella typhimurium/drug effects ; Toxaphene/*pharmacology
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    Permeability of the cell-to-cell membrane channels in mammalian cell juncton (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J -- Simpson, I -- Loewenstein, W R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/physiology ; *Cell Membrane Permeability ; Cells, Cultured ; Cricetinae ; Fluorescent Antibody Technique ; Kidney ; Mice ; Mice, Inbred BALB C ; Species Specificity
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  • 52
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    Calcitonin: inhibitory effect on eating in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Perlow, M J -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):850-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects ; Calcitonin/administration & dosage/*pharmacology ; Depression, Chemical ; Diuresis/drug effects ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Injections, Intraventricular ; Rats
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    Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Newell, N -- Richards, J -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA, Recombinant ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Liver ; Mice ; Mice, Inbred BALB C ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics ; Transcription, Genetic
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    Phenacetin studies (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaught, J B -- King, C M -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):637, 639.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493967" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Kidney Injury/chemically induced ; Animals ; Biotransformation ; *Carcinogens ; Humans ; Kidney Neoplasms/chemically induced ; Mice ; Mutation ; Phenacetin/*adverse effects/metabolism
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    "Sontaneous" neoplastic transformation in vitro: a form of foreign body (smooth surface) tumorigenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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    Ethanol embryotoxicity: direct effects on mammalian embryos in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethanol, which causes reduced embryonic cellular proliferation early in gestation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, N A -- Goulding, E H -- Fabro, S -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Ectogenesis/*drug effects ; Embryo, Mammalian/*drug effects ; Ethanol/*toxicity ; Female ; Fetal Growth Retardation/chemically induced ; Pregnancy ; Rats ; *Teratogens
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    Release of luteinizing hormone in male mice during exposure to females: habituation of the response (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coquelin, A -- Bronson, F H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1099-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Diestrus ; Female ; Habituation, Psychophysiologic/*physiology ; Luteinizing Hormone/*metabolism ; Male ; Mice ; Pregnancy ; Sexual Behavior, Animal/physiology
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    Human chorionic gonadotropin: induction of ovulation in the squirrel monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: The minimum dose of human chorionic gonadotropin that would cause ovulation in the squirrel monkey (Saimiri sciureus) was found to be between 100 and 250 international units.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dukelow, W R -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):234-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113874" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Follicle Stimulating Hormone/pharmacology ; Haplorhini/*physiology ; Ovulation/*drug effects ; Saimiri/*physiology
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    A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32--36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This combination of actions is presently unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice; this also is a property of thymopoietin. These results suggest that this readily synthesized pentapeptide corresponds to an active site of thymopoietin and might serve as a therapeutic substitute for thymopoietin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, G -- Scheid, M P -- Boyse, E A -- Schlesinger, D H -- Van Wauwe, J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1309-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451537" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Surface/analysis ; Cell Differentiation/drug effects ; Complement System Proteins ; Isoantigens/analysis ; Lymphocytes/cytology/*immunology ; Mice ; Mice, Nude/immunology ; Oligopeptides/chemical synthesis/*pharmacology ; Receptors, Drug/analysis ; Structure-Activity Relationship ; Thymopoietins/*pharmacology ; Thymus Hormones/*pharmacology
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    Opiate (Enkephalin) receptors of neuroblastoma cells: occurrence in clusters on the cell surface (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: A bioactive, fluorescent derivative of enkephalin, Tyr-D-Ala-Gly-Phe-Leu-Lys-rhodamine, was used to determine the distribution of opiate receptors in living neuroblastoma cells. The receptors appeared in clusters on the cell surface, and no internalization was detected. No specific fluorescence or clusters were observed in the presence of [D-Ala2, Leu5]enkephalin or at 4 degrees C, and the clusters were much reduced under ionic conditions (that is, with 100 millimolars sodium) that specifically decrease the binding of opiate agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Mice ; Microscopy, Fluorescence ; Neoplasms, Experimental/metabolism ; Neuroblastoma/*metabolism ; Receptors, Opioid/*metabolism ; Synaptic Membranes/metabolism
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    beta-Adrenergic regulation of adenosine 3',5'-monophosphate concentration in brain microvessels (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Norepinephrine increases the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in an incubated suspension of brain microvessels. This response can be matched by other drugs that stimulate the beta receptors, but the alpha-adrenergic agonist phenylephrine is without effect; beta-adrenergic blockade abolishes the response while alpha-adrenergic blockade produces no change. The data support the contention that cerebral capillary function is subject to adrenergic neural control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herbst, T J -- Raichle, M E -- Ferrendelli, J A -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/34879" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic beta-Agonists/*pharmacology ; Animals ; Capillaries/innervation/*metabolism ; *Cerebrovascular Circulation ; Cyclic AMP/*metabolism ; Dose-Response Relationship, Drug ; Male ; Norepinephrine/pharmacology ; Rats ; Sympatholytics/pharmacology
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    Monoclonal antibodies defining distinctive human T cell surface antigens (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kung, P -- Goldstein, G -- Reinherz, E L -- Schlossman, S F -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):347-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/314668" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Antigens, Surface/*analysis ; Cells, Cultured/immunology ; Clone Cells/immunology ; Humans ; Leukemia, Experimental/immunology ; Mice ; Plasmacytoma/immunology ; T-Lymphocytes/*immunology
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    Response of cat inferior colliculus neurons to binaural beat stimuli: possible mechanisms for sound localization (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: The interaural phase sensitivity of neurons was studied through the use of binaural beat stimuli. The response of most cells was phase-locked to the beat frequency, which provides a possible neural correlate to the human sensation of binaural beats. In addition, this stimulus allowed the direction and rate of interaural phase change to be varied. Some neurons in our sample responded selectively to manipulations of these two variables, which suggests a sensitivity to direction or speed of movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuwada, S -- Yin, T C -- Wickesberg, R E -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):586-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493964" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Cats ; Evoked Potentials ; Inferior Colliculi/*physiology ; Motion Perception/physiology ; Orientation/*physiology ; Periodicity
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    Beta-adrenergic-sensitive adenylate cyclase in secretory cells of choroid plexus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Biochemical evidence supporting the sympathetic control of cerebrospinal fluid production has been obtained through identification of a specific beta-adrenergic-sensitive adenylate cyclase in the choroid plexus. The enzyme, which is localized in the secretory epithelium, is activated by low concentrations of isoproterenol and norepinephrine and appears separate from beta-adrenergic-sensitive adenylate cyclase present in cerebral blood vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, J A -- New York, N.Y. -- Science. 1979 May 25;204(4395):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/220707" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Cats ; Cattle ; Cerebrospinal Fluid/metabolism ; Cerebrovascular Circulation ; Choroid Plexus/*enzymology/metabolism ; Dogs ; Enzyme Activation/drug effects ; Epithelium/enzymology ; Isoproterenol/pharmacology ; Rabbits ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
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    Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcu, K B -- Schibler, U -- Perry, R P -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1087-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; Cell Nucleus/metabolism ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/immunology ; Nucleic Acid Precursors/genetics ; Plasmacytoma/immunology ; Poly A/metabolism ; RNA, Heterogeneous Nuclear/genetics ; *Transcription, Genetic
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    Genetic effects of impure and pure saccharin in yeast (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-07
    Description: Yeast cells were grown in media containing impure or purified saccharin preparations. Dose-dependent increases in frequencies of cells possessing aberrant cell morphologies were revealed by light microscopy. At each test dose, cells grown in impure saccharin exhibited up to sevenfold higher frequencies of mitotic crossing-over or gene conversion in three of four assays for genetic recombination than cells grown in purified saccharin from the same lot. With one exception, the sweetener produced by the Maumee process caused larger increases in recombination and gene reversion than the sweetener produced by the Remsen-Fahlberg process. The several test markers did not respond equally to any test saccharin. Cells grown in liquid media containing no saccharin or two of three test concentrations of saccharin produced cell titers that were approximately equivalent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, C W -- Schmick, A -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1007-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382356" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Crossing Over, Genetic/drug effects ; Dose-Response Relationship, Drug ; Mitosis/drug effects ; *Mutagens ; Recombination, Genetic/drug effects ; Saccharin/chemical synthesis/*pharmacology ; Saccharomyces cerevisiae/*drug effects ; Structure-Activity Relationship
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    Novel activation mechanism for the promutagenic herbicide diallate (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-07
    Description: The potent bacterial mutagen 2-chloroacrolein is formed from the carcinogenic herbicide S-2,3-dichloroallyl diisopropylthiocarbamate (diallate) on incubation with hepatic microsomal monooxygenases or on reaction with m-chloroperbenzoic acid. A proposed activation mechanism for this promutagen involves sulfoxidation followed by [2,3] sigmatropic rearrangement and 1,2-elimination reactions. A portion of the highly reactive intermediate, diallate sulfoxide (proximate mutagens), is attacked by glutathione in a reaction which competes with its transformation to the ultimate mutagen, 2-chloroacrolein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schuphan, I -- Rosen, J D -- Casida, J E -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1013-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472719" target="_blank"〉PubMed〈/a〉
    Keywords: Acrolein/pharmacology ; Animals ; Biotransformation ; Herbicides/*metabolism/pharmacology ; Mice ; Microsomes, Liver/metabolism ; *Mutagens ; Mutation/drug effects ; Rats ; Thiocarbamates/*metabolism/pharmacology
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    A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paigen, K -- Labarca, C -- Watson, G -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):554-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760204" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Enzyme Induction/drug effects ; Female ; Genes ; *Genes, Regulator ; Genetic Linkage ; Glucuronidase/*genetics ; Hot Temperature ; Kidney/*enzymology ; Mice ; Oocytes/metabolism ; RNA, Messenger/*genetics ; Testosterone/pharmacology ; Xenopus
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    Stress and coping factors influence tumor growth (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-03
    Description: Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated as a result of various stress regimens. A single session of inescapable shock resulted in earlier tumor appearance, exaggeration of tumor size, and decreased survival time in recipient animals. Escapable shock had no such effects. The effects of the inescapable shock were mitigated if mice received long-term shock treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sklar, L S -- Anisman, H -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):513-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electroshock ; Humans ; Male ; Mast-Cell Sarcoma/complications/*physiopathology ; Mice ; Neoplasms, Experimental/complications/physiopathology ; Stress, Psychological/complications/*physiopathology
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    Mediatory role of calcium and guanosine 3', 5'-monophosphate in adrenocorticotropin-induced steroidogenesis by adrenal cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: When incubated in a calcium-free medium, isolated rat fasciculata cells showed neither an increase in the concentration of guanocine 3',5'-monophosphate (cyclic GMP) nor an increase in corticosterone production in response to adrenocorticotropic hormone (ACTH). In response to submaximum and maximum steroidogenic concentrations of ACTH, corticosterone formation was directly proportional to increases in calcium concentration ranging from 0 to 2.5 mM. Higher concentration of calcium, however, inhibited maximal ACTH-induced steroidogenesis. In the absence of ACTH, calcium did not stimulate cyclic GMP accumulation and corticosterone formation. ACTH-induced corticosterone synthesis, preceded by an increase in cyclic GMP, was restored when ACTH and calcium were both present in the medium. Cyclic GMP or dibutryl cyclic GMP-induced steroidogenesis was substantially reduced in the absence of calcium, but in contrast to the ACTH effect a significant amount of corticosterone formation occurred without calcium. It is proposed that at the physiological concentrations of the hormone, calcium regulates the transduction of information between hormone receptors and guanylate cyclase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perchellet, J P -- Sharma, R K -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/34216" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/*drug effects/metabolism ; Adrenal Cortex Hormones/*biosynthesis ; Adrenocorticotropic Hormone/*pharmacology ; Animals ; Calcium/*pharmacology ; Cyclic GMP/*pharmacology ; Dibutyryl Cyclic GMP/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Guanylate Cyclase/metabolism ; In Vitro Techniques ; Models, Biological ; Rats
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  • 71
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    Localization of the neurally mediated arrhythmogenic properties of digitalis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Available evidence suggests that the propensity of digitalis glycosides to produce cardiac arrhythmias is due in part to their neuroexictatory effects. We have performed experiments in cats which support the existence of a neurogenic component in the etiology of digitalis-induced ventricular arrhythmias. Our data further indicate that the locus of this neural effect lies within an area of the medulla 2 millimeters above to 2 millimeters below the obex. These findings, when considered with the effects of polar cardiac glycosides that do not cross the blood-brain barrier, suggest that the area postrema may be the site of neural activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Somberg, J C -- Smith, T W -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):321-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219481" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arrhythmias, Cardiac/*chemically induced ; Brain Stem/*physiology ; Cats ; Digitalis Glycosides/*pharmacology/toxicity ; Dose-Response Relationship, Drug ; Heart/*drug effects/innervation ; Myocardium/*metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Spinal Cord/physiology ; Vagus Nerve/physiology
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  • 72
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    Plasticity: the mirror of experience (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-05
    Description: A simple avoidance training procedure during early development produces massive neural traces in visual and somatic cortices of kittens reared in a normal environment. A preponderance of cells in these areas had response preferences for the stimuli used during training. Furthermore, some of these cells exhibited properties never found in normal animals not receiving such training. It appears that, even in an environment in which many other stimuli are present, some early experiences powerfully affect brain development and the way in which other experiences exert their effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spinelli, D N -- Jensen, F E -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):75-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758683" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/physiology ; Cats ; Environment ; Functional Laterality ; Memory/physiology ; Orientation/physiology ; Somatosensory Cortex/*growth & development/physiology ; Visual Cortex/*growth & development/physiology
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  • 73
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    Morphine-naloxone interactions: a role for nonspecific morphine excitatory effects in withdrawal (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: The opiate antagonist naloxone precipitates withdrawal when given either 15 minutes after or 1 minute before a single injection of morphine in drug-naive mice. We propose that withdrawal signs arise from a synergistic mixture of excitatory influences that are direct (agonistic action on nonspecific opiate receptors) and indirect (sensory and affective disorders, stress, hormonal and neurotransmitter dysfunction, and so forth). The predominant effects during precipitated withdrawal are assumed to be direct, whereas during abstinence in tolerant animals they are indirect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stevens, D R -- Klemm, W R -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1379-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224462" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Tolerance ; Female ; Humans ; Mice ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Receptors, Opioid/*drug effects ; Stereotyped Behavior/physiology ; Substance Withdrawal Syndrome/*physiopathology
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  • 74
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    Simultaneous production of Q and R bands after staining with chromomycin A3 or olivomycin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-06
    Description: Human and mouse chromosomes, stained with either chromomycin A3 or olivomycin, which bind preferentially to G - C-rich DNA (where G is guanosine and C is cytosine), exhibit a Q or a reverse banding pattern, depending on the wavelength used for excitation. The two complementary banding patterns can be observed in the same metaphase simply by changing the combination of excitation filters. These data suggest, therefore, that in addition to base composition, other factors are involved in the production of chromosome banding by chromomycin A3 and olivomycin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prantera, G -- Bonaccorsi, S -- Pimpinelli, S -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):79-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/86207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cells, Cultured ; Centromere/ultrastructure ; *Chromomycins ; Chromosomes/*ultrastructure ; *Dna ; Fluorescent Dyes ; Humans ; Mice ; *Olivomycins ; Staining and Labeling
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  • 75
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    Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prehn, L M -- Lawler, E M -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):309-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432644" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/genetics/metabolism ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Immunologic ; Female ; Genes ; Male ; *Methylcholanthrene ; Mice ; Mice, Inbred Strains/*physiology ; Sarcoma, Experimental/*chemically induced/immunology
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  • 76
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    Exercise during development induces an increase in Purkinje cell dendritic tree size (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-12
    Description: Mice allowed to exercise during the late postnatal period had Purkinje cells with larger dendritic trees and greater numbers of spines than littermates whose physical activity was severly restricted. These changes in Purkinje cells were accompanied by a selective reduction in the thickness of the cerebellar molecular layer. The data provide evidence for cerebellar plasticity during late development and demonstrate that physical activity can modify the development of Purkinje cell dendrites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pysh, J J -- Weiss, G M -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):230-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482938" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Cell Differentiation ; Cerebellar Cortex/growth & development ; Cerebellum/*growth & development ; Dendrites/ultrastructure ; Female ; Male ; Mice ; Motor Activity/physiology ; Physical Exertion ; Purkinje Cells/*cytology
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  • 77
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    Differential competition with cytotoxic agents: an approach to selectivity in cancer chemotherapy (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: An approach to increasing the selectivity of cancer chemotherapeutic agents is presented in which noncytotoxic competitive substrates are used to discern the differences in structural requirements for transport of cytotoxic agents between tumor cells and a sensitive host tissue, the hematopoietic precursor cells of the bone marrow. Examples are given for two such systems, one responsible for the transport of nucleosides and another for the transport of amino acids. Cytidine is twice as effective in reducing the toxicity of showdomycin for murine bone marrow cells in culture as it is for murine L1210 leukemia cella. Conversely, homoleucine is twice as effective in reducing the toxicity of melphalan for L1210 cells as it is for bone marrow cells. These observations can serve as a basis for the development of bone marrow protective agents and for the design of cytotoxic agents that may be preferentially transported into tumor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabinowitz, M -- Uehara, Y -- Vistica, D T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1085-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493993" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibiotics, Antineoplastic/*metabolism ; Biological Transport ; Bone Marrow/drug effects ; Leukemia L1210/drug therapy ; Melphalan/metabolism/therapeutic use ; Mice ; Neoplasms/*drug therapy ; Showdomycin/*metabolism/therapeutic use ; Structure-Activity Relationship
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  • 78
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    6-Hydroxydopamine potentiates acute herpes simplex virus infection of the superior cervical ganglion in mice (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-03
    Description: Treatment of mice with 6-hydroxydopamine increased herpes simplex virus replication in the superior cervical ganglion while it decreased the subsequent prevalence of latent infection. Preganglionic neurectomy failed to block this effect. These observations suggest that intrinsic neural events modify the outcome of viral infections of the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Price, R W -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):518-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221984" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascorbic Acid/pharmacology ; Eye Diseases/immunology ; Female ; Ganglia, Autonomic/drug effects/*microbiology ; Herpes Simplex/immunology ; Hydroxydopamines/*pharmacology ; Immunity ; Mice ; Mice, Inbred BALB C ; Simplexvirus/drug effects/immunology/*pathogenicity
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  • 79
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    ACTH and vasopressin treatments immediately after a defeat increase future submissiveness in male mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Male mice were given a single injection of either adrenocorticotropic hormone (ACTH) or lysine vasopressin immediately after a defeat in an encounter with an aggressive male mouse. The defeated mice were tested for submissiveness at either 24 hours, 48 hours, or 7 days after the initial encounter. Both hormone treatments increased future submissiveness, although the time courses of the effects were different: The effects of ACTH disappeared after 48 hours, whereas those of vasopressin persisted for 7 days. These results suggest that changes in peptide hormone levels following naturally stressful experiences can affect the memory of those experiences, as expressed in future adaptive responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roche, K E -- Leshner, A I -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1343-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221973" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*pharmacology ; Aggression/*drug effects ; Animals ; Behavior, Animal/*drug effects ; Humans ; Lypressin/*pharmacology ; Male ; Mice ; Stress, Psychological/physiopathology
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  • 80
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    Thyroid hormone influence on the susceptibility of mice to audiogenic seizures (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-10
    Description: Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enhanced by treatment with excess thyroxine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seyfried, T N -- Glaser, G H -- Yu, R K -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):598-600.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451624" target="_blank"〉PubMed〈/a〉
    Keywords: *Acoustic Stimulation ; Animals ; Hyperthyroidism/blood ; Hypothyroidism/blood ; Mice ; Mice, Inbred Strains ; Propylthiouracil ; Seizures/*blood ; Thyroxine/*blood/pharmacology
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  • 81
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    Institute of Medicine report recommends complete overhaul of food safety laws (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1221-2, 1224.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424748" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; Dose-Response Relationship, Drug ; Food Additives/*standards ; Saccharin ; United States ; United States Food and Drug Administration
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  • 82
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    Cholecystokinin in the brains of obese and nonobese mice (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-05
    Description: Extracts of the cerebral cortes of genetically obese (ob/ob) mice with hyperphagia contain 0.05 +/- 0.02 microgram (mean +/- standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 +/- 0.01 microgram per gram for their nonobese littermates and 0.20 +/- 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Straus, E -- Yalow, R S -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):68-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758680" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Cholecystokinin/*metabolism ; Mice ; Mice, Obese/*metabolism ; Satiation/physiology
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  • 83
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    Thyroxine increases nerve growth factor concentration in adult mouse brain (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-27
    Description: The effects of thyroxine and propylthiouracil on nerve growth factor concentrations in cerebral cortex, cerebellum, and brainstem of adult male mice were assessed by using a sensitive radioimmunoassay for the beta-subunit of mouse nerve growth factor. Thyroxine administration significantly increased the concentration of nerve growth factor in all three brain areas compared to control values, whereas propylthiouracil was without effect. These results suggest that thyroid hormones stimulate nerve growth factor synthesis in the mature central nervous system, and raise the possibility that the influence of thyroid hormones on central nervous system development might be mediated or influenced by nerve growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, P -- Weichsel, M E Jr -- Fisher, D A -- Guo, S M -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Brain Stem/metabolism ; Cerebellum/metabolism ; Cerebral Cortex/metabolism ; Mice ; Microtubules/metabolism ; Nerve Growth Factors/*metabolism ; Propylthiouracil/pharmacology ; Thyroxine/*pharmacology
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  • 84
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    Carcinogenicity of phenacetin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tomatis, L -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):129-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432634" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Mice ; Neoplasms/*chemically induced ; Phenacetin/*toxicity ; Rats
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  • 85
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    Long-term amphetamine treatment decreases brain serotonin metabolism: implications for theories of schizophrenia (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-21
    Description: Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trulson, M E -- Jacobs, B L -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1295-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Brain/*metabolism ; Brain Chemistry/*drug effects ; Cats ; Dextroamphetamine/*pharmacology ; Disease Models, Animal ; Female ; Humans ; Hydroxyindoleacetic Acid/metabolism ; Schizophrenia/*physiopathology ; Serotonin/*metabolism ; Time Factors
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  • 86
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    GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-24
    Description: A "recptor unit" for gamma-aminobutyric acid (GABA), which includes brainlike receptor binding sites for tritium-labeled GABA and benzodiazepines (diazepam, clonazepam, and flunitrazepam) and a thermostable endogenous protein (GABA modulin) that inhibits both GABA and benzodiazepine binding, has been demonstrated in membranes prepared from NB2a neuroblastoma and C6 glioma clonal cell lines. In these cells, as in brain, diazepam (1 micromolar) prevents the effect of GABA modulin, and in turn GABA (0.oma and, to a lesser extent, the glioma cells represent a suitable model to study the interactions and the sequence of membrane and intracellular events triggered by the stimulation of benzodiazepine and GABA receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baraldi, M -- Guidotti, A -- Schwartz, J P -- Costa, E -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):821-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Brain/*metabolism ; Cell Line ; Clonazepam/metabolism ; Clone Cells/metabolism ; Diazepam/metabolism/pharmacology ; Flunitrazepam/metabolism ; Membrane Proteins/pharmacology ; Mice ; Nerve Tissue Proteins/pharmacology ; Rats ; Receptors, Drug/*metabolism ; gamma-Aminobutyric Acid/*metabolism
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  • 87
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    Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brozoski, T J -- Brown, R M -- Rosvold, H E -- Goldman, P S -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):929-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Behavior, Animal/drug effects/physiology ; Cerebral Cortex/*physiology ; Cognition/drug effects/*physiology ; Dihydroxyphenylalanine/analogs & derivatives/pharmacology ; Dopamine/*physiology ; Dose-Response Relationship, Drug ; Haplorhini ; Levodopa/pharmacology ; Macaca mulatta ; Norepinephrine/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 88
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    How to assess cancer risks (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1979 May 25;204(4395):811, 813, 815-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Government Agencies ; Humans ; Mice ; Neoplasms/*chemically induced ; Rats ; Risk ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    Chemical carcinogenesis: dose-response extrapolation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clayson, D B -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1068-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424732" target="_blank"〉PubMed〈/a〉
    Keywords: Dose-Response Relationship, Drug ; Neoplasms/*chemically induced
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    Perinatal exposure to cannabinoids alters male reproductive function in mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Oral administration of delta 9-tetrahydrocannabinol or cannabinol to female mice late in pregnancy and during early lactation alters body weight regulation and pituitary-gonadal function and suppresses adult copulatory activity in their male offspring. These findings suggest that both psychoactive and nonpsychoactive constituents of marihuana can affect the development of male reproductive functions in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalterio, S -- Bartke, A -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1420-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472762" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Body Weight/drug effects ; Cannabinoids/*pharmacology ; Cannabinol/*pharmacology ; Copulation/drug effects ; Dronabinol/*pharmacology ; Male ; Mice ; Organ Size/drug effects ; Pituitary Hormones/blood ; Sex Differentiation/*drug effects ; Sexual Behavior, Animal/*drug effects ; Sexual Maturation/drug effects ; Testis/anatomy & histology ; Testosterone/blood
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Conditioned inhibition: selective response of single units (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Single cell activity and local field potentials in parastriate cortex of cats and rabbits were studied during a Pavlovian discrimination procedure. Cell activity was selectively modified; conditioned changes occurred in response either to the reinforced stimulus or to the unreinforced one, but not to both. Cells exhibiting conditioned alteration in response to the unreinforced stimulus are thought to participate in specialized circuits mediating conditioned inhibition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Toledo-Morrell, L -- Hoeppner, T J -- Morrell, F -- New York, N.Y. -- Science. 1979 May 4;204(4392):528-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432660" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Cerebral Cortex/physiology ; Conditioning (Psychology)/*physiology ; Neural Inhibition ; Rabbits ; Reinforcement (Psychology) ; Visual Cortex/*physiology ; Visual Perception/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    The central origin of efferent pathways in the carotid sinus nerve of the cat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: The application of horseradish peroxidase to the central cut end of the carotid sinus nerve of the cat produced retrograde labeling of neurons in the ipsilateral medulla in the region of the nucleus ambiguus at anterior-posterior coordinates -8 to -10.5. These data coupled with previous electrophysiological observations suggest that the nucleus ambiguus may be the origin of an efferent inhibitory pathway to the carotid body.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉deGroat, W C -- Nadelhaft, I -- Morgan, C -- Schauble, T -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1017-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carotid Sinus/cytology/*innervation ; Cats ; Efferent Pathways/cytology ; Glossopharyngeal Nerve/cytology ; Horseradish Peroxidase ; Medulla Oblongata/cytology ; Neural Inhibition
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  • 93
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    GABA receptor control of parasympathetic outflow to heart: characterization and brainstem localization (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Blockade of gamma-aminobutyric acid (GABA) receptor function by direct microinjection of the GABA receptor antagonist bicuculline into the nucleus ambiguus of the brainstem produced a marked, dose-related depression of heart rate and blood pressure which was mediated by the vagus nerve. This effect was not obtained in other regions of the brainstem and was reversed by the GABA receptor agonist muscimol. These data indicate that the nucleus ambiguus may be the site of a GABA receptor-mediated inhibition of vagal outflow.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiMicco, J A -- Gale, K -- Hamilton, B -- Gillis, R A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1106-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bicuculline/pharmacology ; Blood Pressure/drug effects ; Brain Stem/*physiology ; Cats ; Heart/*innervation ; Heart Rate/drug effects ; Isoniazid/pharmacology ; Muscimol/pharmacology ; Receptors, Drug/*physiology ; Vagus Nerve/*physiology ; gamma-Aminobutyric Acid/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Eye movements initiate visual-motor development in the cat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Visually naive kittens turn their eyes toward visual targets but lack other visual-motor coordinations. Light-reared animals were able to mediate guided behaviors with an immobilized eye, but animals with the eye immobilized before initial exposure to a lighted environment were not. Eye movement is implied to play an essential role in visual-motor development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hein, A -- Vital-Durand, F -- Salinger, W -- Diamond, R -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/313076" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Cats ; Darkness ; *Eye Movements ; Functional Laterality ; Locomotion ; *Movement ; Vestibule, Labyrinth/physiology ; Visual Pathways/*growth & development ; Visual Perception/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Phase resetting and annihilation of pacemaker activity in cardiac tissue (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: Spontaneous rhythmic activity in isolated cardiac pacemaker cells can be terminated by a brief, subthreshold, depolarizing or hyperpolarizing perturbation of the proper magnitude applied at a specific point in the pacemaker cycle. Evidence is provided in support of a topological theory of the existence of a "singular" point in cardiac oscillators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jalife, J -- Antzelevitch, C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):695-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493975" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Cattle ; Dogs ; Evaluation Studies as Topic ; Heart Conduction System/*physiology ; Membrane Potentials ; *Periodicity ; Purkinje Fibers/*physiology ; Sinoatrial Node/*physiology
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  • 96
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    Prednisone therapy and birth weight (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jefferies, W M -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):96-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482932" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex Hormones/*adverse effects ; Birth Weight/drug effects ; Cortisone/adverse effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydrocortisone/adverse effects ; Prednisone/*adverse effects ; Pregnancy
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  • 97
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    Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: A series of recombinant plasmids containing polyoma virus (PY) DNA were constructed, and their biological activity was evaluated in mice and in cultured mouse cells. While all of the recombinants studied contain the complete, potentially infectious viral DNA, in no case was the intact recombinant PY-plasmid DNA, or live Escherichia coli containing the recombinant plasmids, capable of inducing PY infection of mice, either by feeding or by parenteral injection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Israel, M A -- Chan, H W -- Rowe, W P -- Martin, M A -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):883-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/217087" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chromosome Mapping ; *DNA, Recombinant ; DNA, Viral/genetics ; Escherichia coli/*genetics ; Mice ; *Plasmids ; Polyomavirus/*genetics ; Transcription, Genetic ; Tumor Virus Infections/*genetics ; Virus Replication
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, G G -- Eisenberg, L R -- Migeon, B R -- New York, N.Y. -- Science. 1979 Jan 12;203(4376):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569362" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Female ; Genetic Linkage ; Humans ; Hybrid Cells/enzymology ; *Hypoxanthine Phosphoribosyltransferase/genetics ; Macromolecular Substances ; Mice ; Molecular Weight ; Protein Conformation ; X Chromosome
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  • 99
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    Choline excites cortical neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: In cats under halothane or methoxyflurane, iontophoretic applications of choline are only eight times weaker than applications of acetylcholine in evoking firing of neurons in the sensorimotor region of the cerebral cortex. The action of choline is suppressed by atropine but not by two agents that block choline uptake (hemicholinium-3 and triethylcholine), and is not potentiated by an anticholinesterase (physostigmine). Choline therefore appears to excite cortical neurons by a direct action, which may be a significant component of its beneficial therapeutic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krnjevic, K -- Reinhardt, W -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1321-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515735" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/pharmacology ; Action Potentials/drug effects ; Animals ; Cats ; Cerebral Cortex/*drug effects ; Choline/*pharmacology ; Drug Synergism ; Evoked Potentials ; Glutamates/pharmacology ; Hemicholinium 3/pharmacology ; Motor Cortex/physiology ; Physostigmine/pharmacology ; Receptors, Muscarinic/drug effects ; Stimulation, Chemical
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Killing of fibroblasts by dexamethasone or dibutyryl adenosine 3',5'-monophosphate is not a valid test for cystic fibrosis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Assays based on the counting of total cells and of colony-forming cells were used to demonstrate that neither dexamethasone nor dibutyryl adenosine 3',5'-monophosphate (cyclic AMP) kills human fibroblasts under a variety of conditions. These results contradict those of previous studies showing that dexamethasone and dibutyryl cyclic AMP kill a higher percentage of fibroblasts from normal humans than from individuals with cystic fibrosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurz, J B -- Perkins, J P -- Buchwald, M -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1317-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/229552" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Bucladesine/*pharmacology ; Cell Division/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Child ; Child, Preschool ; Cystic Fibrosis/*diagnosis ; Dexamethasone/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Fibroblasts/*drug effects ; Humans ; Ouabain/pharmacology ; Skin/cytology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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