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  • Kinetics  (136)
  • Rats, Inbred Strains  (103)
  • Genes  (91)
  • Chemistry
  • Physics
  • American Association for the Advancement of Science (AAAS)  (356)
  • 1980-1984  (356)
  • 1925-1929
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  • 1
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    Single-nutrient microbial competition: qualitative agreement between experimental and theoretically forecast outcomes (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: When microbial strains compete for the same limiting nutrient in continuous culture, resource-based competition theory predicts that only one strain will survive and all others will die out. The surviving strain expected from theory will be the one with the smallest subsistence or "break-even" concentration of the limiting resource, a concentration defined by the J parameter. This prediction has been confirmed in the case of auxotrophic bacterial strains competing for limiting tryptophan. Because the value of J can be measured on the strains grown alone, the theory can predict the qualitative outcomes of mixed-growth competition in advance of actual competition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, S R -- Hubbell, S P -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6767274" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/*growth & development ; Culture Media ; Drug Resistance, Microbial ; Escherichia coli/growth & development ; Kinetics ; Models, Theoretical ; Nalidixic Acid/pharmacology ; Nutritional Physiological Phenomena ; Pseudomonas aeruginosa/growth & development ; Tryptophan/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: The patterns of the occurrence of breast cancer in 11 high-risk families were evaluated by segregation and linkage analysis. These patterns were consistent with the hypothesis that increased susceptibility to breast cancer was inherited as an autosomal dominant allele with high penetrance in women. The postulated susceptibility allele in these families may be chromosomally linked to the glutamate-pyruvate transaminase (E.C. 2.6.1.2, alanine aminotransferase) locus. Confirmation of this linkage in other families would establish the existence of a gene increasing susceptibility to breast cancer. Since there is no association in the general population between a woman's glutamate-pyruvate transaminase genotype and her cancer risk, the glutamate-pyruvate transaminase linkage cannot be used as a screening test for breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, M C -- Go, R C -- Elston, R C -- Lynch, H T -- Petrakis, N L -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):406-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367867" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine Transaminase/*genetics ; Alleles ; Breast Neoplasms/*genetics/transmission ; Female ; Genes ; Genetic Linkage ; Humans ; Pedigree ; X Chromosome
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  • 3
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    Tooth induction in chick epithelium: expression of quiescent genes for enamel synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-29
    Description: Intraocular grafts of chick epithelium combined with mouse molar mesenchyme produced a variety of dental structures including perfectly formed crowns with differentiated ameloblasts depositing enamel matrix. The results suggest that the loss of teeth in Aves did not result from a loss of genetic coding for enamel synthesis in the oral epithelium but from an alteration in the tissue interactions requisite for odontogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kollar, E J -- Fisher, C -- New York, N.Y. -- Science. 1980 Feb 29;207(4434):993-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352302" target="_blank"〉PubMed〈/a〉
    Keywords: *Amelogenesis ; Animals ; Chick Embryo/*cytology ; Culture Techniques ; Dental Enamel Proteins/*biosynthesis/genetics ; Embryonic Induction ; Epithelial Cells ; Genes ; Mandible/cytology ; Mesoderm/cytology ; Mice ; *Odontogenesis
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  • 4
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    Immunoglobulin gene rearrangement in immature B cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z/3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes. In the fetal liver hybridomas, which were constructed from fetal liver cells and a tumor cell, no light chain gene rearrangement was observed, whereas in the 70Z/3 cell line a kappa light chain rearrangement probably occurred. The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maki, R -- Kearney, J -- Paige, C -- Tonegawa, S -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1366-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Genes ; Hybrid Cells/immunology ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Leukemia, Experimental/*immunology ; Liver/*embryology ; Mice ; Recombination, Genetic ; Transcription, Genetic
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  • 5
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    The heart is a target organ for androgen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-15
    Description: Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known, the presence of this receptor suggests that sex steroid hormones may affect myocardial function directly and may explain some of the peculiar differences in heart disease between men and women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGill, H C Jr -- Anselmo, V C -- Buchanan, J M -- Sheridan, P J -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766222" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*metabolism ; Animals ; Coronary Disease/*etiology ; Dihydrotestosterone/metabolism ; Estradiol/metabolism ; Female ; Haplorhini ; Kinetics ; Macaca mulatta ; Myocardium/*metabolism ; Papio ; Receptors, Androgen/*metabolism ; Receptors, Steroid/*metabolism ; Sex Factors
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  • 6
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    J genes for heavy chain immunoglobulins of mouse (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-05
    Description: A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of heavy chain variable regions. These genes are located in genomic DNA about eight kilobase pairs to the 5' side of the CHmu gene. The complete nucleotide sequence of a 1120-base pair stretch of DNA that includes the two J genes has been determined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newell, N -- Richards, J E -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1128-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250219" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites, Antibody/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Genes ; Genetic Linkage ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin mu-Chains/*genetics ; Mice
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  • 7
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    Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver sytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C3H.SW/haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2d region of the major histocompatibility complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novak, R -- Bosze, Z -- Matkovics, B -- Fachet, J -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):86-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Genes ; Genes, Regulator ; Genetic Linkage ; H-2 Antigens/*genetics ; Liver/enzymology ; *Major Histocompatibility Complex ; Mice ; Superoxide Dismutase/*genetics
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  • 8
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    Calcium regulation during stimulus-secretion coupling: continuous measurement of intracellular calcium activities (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Accurate measurements of intracellular calcium activities in salivary gland epithelial cells of the insect Phormia regina were obtained with microelectrodes in which N,N'-di(11-ethoxycarbonyl)undecyl-N,N'-4,5-tetramethyl-3,6-dioxaoctane diacid diamide wsa incorporated in a liquid membrane system. When calibrated in solutions approximating the ionic concentration of the cell interior, these microelectrodes gave rapid stable responses that were linear functions of the logarithm of calcium activities and were not affected by potassium, sodium and magnesium. Continuous monitoring of calcium activities during serotonin-induced saliva release provided direct evidence of hormonal influence on transmembrane calcium movement and spontaneous regulation of intracellular calcium by stimulated cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Doherty, J -- Youmans, S J -- Armstrong, W M -- Stark, R J -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):510-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394518" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Diptera/*metabolism ; Epithelium/metabolism ; Kinetics ; Magnesium/pharmacology ; Microelectrodes ; Salivary Glands/drug effects/*metabolism ; Serotonin/pharmacology
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  • 9
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    Altering genotype and phenotype by DNA-mediated gene transfer (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Transformation, or DNA-mediated gene transfer, permits the introduction of new genetic information into a cell and frequently results in a change in phenotype. The transforming DNA is ultimately integrated into a recipient cell chromosome. No unique chromosomal locations are apparent, different lines contain the transforming DNA on different chromosomes. Expression of transformed genes frequently results in the synthesis of new polypeptide products which restore appropriate mutant cells to the wild-type phenotype. Thus transformation provides an in vivo assay for the functional role of DNA sequence organization about specific genes. Transforming genes coding for selectable functions, such as adenine phosphoribosyltransferase or thymidine kinase, have now been isolated by utilizing transformation in concert with molecular cloning. Finally, transformation may provide a general approach to the analysis of complex heritable phenotypes by permitting the distinction between phenotypic changes without concomitant changes in DNA and functional genetic rearrangements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pellicer, A -- Robins, D -- Wold, B -- Sweet, R -- Jackson, J -- Lowy, I -- Roberts, J M -- Sim, G K -- Silverstein, S -- Axel, R -- CA 16346/CA/NCI NIH HHS/ -- CA 17477/CA/NCI NIH HHS/ -- CA 23767/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1414-22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414320" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Phosphoribosyltransferase/*genetics ; Cloning, Molecular/methods ; DNA/*genetics ; *DNA, Recombinant ; Genes ; Genotype ; Mutation ; Pentosyltransferases/*genetics ; Phenotype ; Recombination, Genetic ; Selection, Genetic ; Thymidine Kinase/*genetics ; *Transformation, Genetic
    Print ISSN: 0036-8075
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  • 10
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    Nerve terminals are as metabolically different as the muscle fibers they innervate (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-21
    Description: The rate at which glucose enters nerve terminals in muscle was estimated indirectly by measuring changes in miniature end-plate potential frequency D-Glucose entered nerve terminals in muscles with a fast twitch more rapidly than it entered those with a slow twitch. This suggests that nerve terminals in fast- and slow-twitch muscles differ in their rate of metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickett, J B -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):927-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Diaphragm/innervation ; Glucose/*metabolism ; Kinetics ; Membrane Potentials ; Nerve Endings/*metabolism ; Neuromuscular Junction/*metabolism ; Osmolar Concentration ; Rats
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  • 11
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    Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: The expression of human esterase D was evaluated quantitatively and qualitatively in five persons with partial deletions or duplications of chromosome 13. The results showed that the locus of this enzyme is at band 13q14. Deletion of this same band in other subjects has been found previously to indicate a predisposition to the development of retinoblastoma, which was present in the four individuals in this study who had partial deletions of chromosome 13. Because of this close synteny, esterase D evaluation should aid in the diagnosis and genetic counseling of retinoblastoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sparkes, R S -- Sparkes, M C -- Wilson, M G -- Towner, J W -- Benedict, W -- Murphree, A L -- Yunis, J J -- New York, N.Y. -- Science. 1980 May 30;208(4447):1042-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375916" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Deletion ; Chromosome Mapping ; *Chromosomes, Human, 13-15 ; Esterases/*genetics ; Female ; Genes ; Humans ; Intellectual Disability/enzymology/genetics ; Male ; Retinoblastoma/enzymology/*genetics
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  • 12
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    Directed deletion of a yeast transfer RNA intervening sequence (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Many eukaryotic genes contain intevening sequences, segments of DNA that interrupt the continuity of the gene. They are removed from RNA transcripts of the gene by a process known as splicing. The intervening sequence in a yeast tyrosine transfer RNA (tRNA Tyr) suppressor gene was deleted in order to test its role in the expression of the gene. The altered gene and its parent were introduced into yeast by transformation. Both genes exhibited suppressor function, showing that the intervening sequence is not absolutely essential for the expression of this gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wallace, R B -- Johnson, P F -- Tanaka, S -- Schold, M -- Itakura, K -- Abelson, J -- CA10984/CA/NCI NIH HHS/ -- GM 26391/GM/NIGMS NIH HHS/ -- GM 35658/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1396-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6997991" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chromosome Deletion ; DNA, Recombinant ; Genes ; Mutation ; Nucleic Acid Precursors/genetics ; Plasmids ; RNA, Fungal/*genetics ; RNA, Transfer/*genetics ; Saccharomyces cerevisiae/genetics ; Suppression, Genetic ; Tyrosine
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  • 13
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    Pituitary gonadotropin-releasing hormone receptors during the rat estrous cycle (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-22
    Description: The binding of [6-alanine]gonadotropin-releasing hormone to pituitary plasma membranes increased threefold between metestrus and early proestrus in female rats. Receptor numbers fell rapidly on the afternoon of proestrus coincident with the preovulatory gonadotropin surge. The numbers of receptors for gonadotropin-releasing hormone were positively correlated with concentrations of estradiol in serum; this pattern may be a necessary component of increased pituitary sensitivty to gonadotropin-releasing hormone observed during proestrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savoy-Moore, R T -- Schwartz, N B -- Duncan, J A -- Marshall, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):942-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism ; Estradiol/blood ; *Estrus ; Feedback ; Female ; Follicle Stimulating Hormone/blood ; Gonadotropin-Releasing Hormone/analogs & derivatives/*metabolism ; Kinetics ; Luteinizing Hormone/blood ; Pituitary Gland, Anterior/*metabolism ; Pregnancy ; Progesterone/blood ; Rats ; Receptors, Cell Surface/*metabolism
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  • 14
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    The major histocompatibility complex in man (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dausset, J -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1469-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6792704" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/genetics ; Forecasting ; Genes ; Genes, MHC Class II ; Genetic Linkage ; HLA Antigens/genetics ; Humans ; Immune Tolerance ; Immunity, Cellular ; *Major Histocompatibility Complex ; Polymorphism, Genetic ; Transplantation Immunology
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  • 15
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    Benzodiazepine inhibition of the calcium-calmodulin protein kinase system in brain membrane (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: Benzodiazepines inhibit Ca2+-calmodulin-stimulated membrane protein phosphorylation. The effects of the benzodiazepines on protein phosphorylation are stereospecific and produced by membrane-bound benzodiazepine. The potency of benzodiazepine kinase inhibition is correlated with the ability of the benzodiazepines to inhibit electric shock-induced convulsions. These findings provide evidence that some of the anticonvulsant and neuronal stabilizing effects of benzodiazepines may be modulated by the Ca2+-calmodulin protein kinase system and indicate that this calmodulin-kinase system represents an identifiable benzodiazepine receptor in brain that is distinquishable by several criteria from the previously described high affinity benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeLorenzo, R J -- Burdette, S -- Holderness, J -- NS 1352/NS/NINDS NIH HHS/ -- NSI-EA-1-K04-NS245/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):546-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/metabolism ; Brain/*enzymology ; Calcium/*pharmacology ; Calcium-Binding Proteins/*pharmacology ; Calmodulin/*pharmacology ; Cell Membrane/enzymology ; Chlordiazepoxide/*pharmacology ; Diazepam/*pharmacology ; Enzyme Activation ; Kinetics ; Molecular Weight ; Phosphorylation ; Protein Kinases/*metabolism ; Rats ; Receptors, Drug/metabolism ; Receptors, GABA-A
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  • 16
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    Isolation of biological materials by use of erbium (III)--induced magnetic susceptibilities (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, C H -- Tew, W P -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):653-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256262" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Cations ; *Erbium ; Kinetics ; *Magnetics
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  • 17
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    Increased intracranial self-stimulation in rats after long-term administration of desipramine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: The effects of long- and short-term administration of the tricyclic antidepressant desipramine on intracranial self-stimulation in rats were studied with electrodes in the A10 region of the dopamine-containing cell bodies of the ventromedial tegmentum. Long-term desipramine administration resulted in a significant shift to the left in the ascending portion of the rate--current intensity function, indicating that the activity of the mesolimbic dopamine system was enhanced. These findings point to a possible dopaminergic mechanism of action of antidepressants and support speculations concerning the role of dopamine-containing neurons in the pathophysiology of depression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fibiger, H C -- Phillips, A G -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):683-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7197394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Depression/physiopathology ; Desipramine/*administration & dosage ; Dopamine/*physiology ; Humans ; Limbic System/*physiology ; Male ; Rats ; Rats, Inbred Strains ; Self Stimulation/*drug effects ; Time Factors
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  • 18
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    Vagotomy abolishes cues of satiety produced by gastric distension (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonzalez, M F -- Deutsch, J A -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1283-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Feeding Behavior ; Kinetics ; Male ; Rats ; *Satiation ; *Satiety Response ; Stomach/*physiology ; *Vagotomy
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  • 19
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    Plasmid-assisted molecular breeding: new technique for enhanced biodegradation of persistent toxic chemicals (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: The persistence of synthetic herbicides such as 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and its release in massive amounts as a herbicide (Agent Orange) have created toxicological problems in many countries. In nature, 2,4,5-T is slowly degraded by cooxidation and is not utilized as a sole source of carbon and energy. The technique of plasmid-assisted molecular breeding has led to the development of bacterial strains capable of totally degrading 2,4,5-T by using it as their sole source of carbon at high concentrations (greater than 1 mg/ml). Spectrophotometry and gas chromatography reveal various intermediates during growth of the culture with 2,4,5-T.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kellogg, S T -- Chatterjee, D K -- Chakrabarty, A M -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1133-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302584" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/*metabolism ; Bacteria/*genetics/metabolism ; Biotransformation ; Cell Division ; Kinetics ; Nucleic Acid Hybridization ; *Plasmids
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  • 20
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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  • 21
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    Do jumping genes make evolutionary leaps? (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):634-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256261" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; DNA/*genetics ; Genes ; Recombination, Genetic
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  • 22
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    Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-06-05
    Description: Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorenzo, J A -- Raisz, L G -- AM 07290/AM/NIADDK NIH HHS/ -- AM 18063/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1157-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785885" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology ; Bone Resorption/*drug effects ; Bone and Bones/drug effects/*metabolism ; Calcimycin/*pharmacology ; Calcium/metabolism ; Calcium Radioisotopes ; Cells, Cultured ; DNA/*biosynthesis ; DNA Replication/*drug effects ; Ethers/pharmacology ; Fetus ; Ionomycin ; Ionophores/pharmacology ; Kinetics ; Mice ; Parathyroid Hormone/pharmacology
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  • 23
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    Dietary restriction retards the age-associated loss of rat striatal dopaminergic receptors (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-30
    Description: In male Wistar rats subjected to dietary restriction by alternate days of feeding and fasting the normal age-associated loss of striatal dopamine receptors in the brain was substantially retarded. The mean survival time of the rats on the restricted diet was increased by approximately 40 percent compared to control rats given free access to food. Dopamine receptor concentrations in striata of 24-month-old rats that had been on a restricted diet since weaning were 50 percent higher than those of control animals of the same age, and essentially comparable to 3- and 6-month-old control rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levin, P -- Janda, J K -- Joseph, J A -- Ingram, D K -- Roth, G S -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):561-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291993" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Corpus Striatum/*metabolism ; *Diet ; Fasting ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/*metabolism
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  • 24
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    The AF64a-treated mouse: possible model for central cholinergic hypofunction (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-31
    Description: A loss in the number of functional, sodium ion-dependent, high-affinity choline transport sites was observed in the cortex and hippocampus of mice given an intracerebroventricular injection of 65 nanomoles of AF64A (ethylcholine mustard aziridinium ion) 3 days earlier. Such an effect was not observed in the striatum. This effect of AF64A represents a long-term neurochemical deficit at cholinergic nerve terminals in some brain regions which can lead to a persistent deficiency in central cholinergic transmission. The AF64A-treated animal may thus be a model for certain psychiatric or neurological disorders that appear to involve central cholinergic hypofunction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mantione, C R -- Fisher, A -- Hanin, I -- MH 26320/MH/NIMH NIH HHS/ -- MH/AG 34893/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):579-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6894649" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aziridines/*pharmacology ; Azirines/*pharmacology ; Biological Transport/drug effects ; Brain/drug effects/*metabolism ; Cerebral Cortex/metabolism ; Choline/*analogs & derivatives/*metabolism/pharmacology ; Corpus Striatum/metabolism ; Hippocampus/metabolism ; Kinetics ; Mice ; Sodium/pharmacology ; Synaptosomes/drug effects/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
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    Modulation of parallel fiber excitability by postsynaptically mediated changes in extracellular potassium (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: Field potentials and extracellular potassium concentration ([K+]o) were simultaneously monitored in the molecular layer of the rat cerebellar cortex during stimulation of the parallel fibers. The synaptic field potential elicited by stimulation was reduced by several methods. Reduction of synaptic field potentials was accompanied by a marked increase in the excitability of the parallel fibers. This change in excitability was related to the degree of extracellular K+ accumulation associated with parallel fiber stimulation. These findings support the proposal that increases in [K+]o associated with activity in postsynaptic elements can modulate the excitability of presynaptic afferent fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malenka, R C -- Kocsis, J D -- Ransom, B R -- Waxman, S G -- NS 15589/NS/NINDS NIH HHS/ -- NS-00473/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280695" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/*physiology ; Animals ; Calcium/physiology ; Cerebellar Cortex/*physiology ; Evoked Potentials ; Extracellular Space/physiology ; Male ; Manganese/pharmacology ; Membrane Potentials ; Potassium/*physiology ; Rats ; Rats, Inbred Strains ; Synapses/*physiology
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  • 26
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    Electroconvulsive shock increases tyrosine hydroxylase activity in the brain and adrenal gland of the rat (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-11-06
    Description: A single application of electroconvulsive shock produced a rapid but short-lasting increase in tyrosine hydroxylase activity above control values in the rat adrenal medulla and striatum. After repeated electroconvulsive shock treatment (once per day for 7 days), tyrosine hydroxylase activity increased significantly in the locus ceruleus, nucleus of the tractus solitarius, hippocampus, cerebellum, and frontal cortex and remained elevated for 4 to 8 days. Adrenal tyrosine hydroxylase activity increased 1 day after the termination of repeated electroconvulsive shock treatments and remained elevated for at least 24 days, possibly reflecting the establishment of a new and higher steady-state level of catecholamine biosynthesis in the adrenal. These findings suggest that the persistent changes in tyrosine hydroxylase activity produced by repeated electroconvulsive shock may be a factor contributing to the long-lasting antidepressant effects of this treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masserano, J M -- Takimoto, G S -- Weiner, N -- NS 07927/NS/NINDS NIH HHS/ -- NS 09199/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):662-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117127" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*enzymology ; Animals ; Brain/*enzymology ; Corpus Striatum/enzymology ; *Electroshock ; Enzyme Induction ; Locus Coeruleus/enzymology ; Male ; Rats ; Rats, Inbred Strains ; Time Factors ; Tyrosine 3-Monooxygenase/*metabolism
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  • 27
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    Changes in DNA during meiosis in a repair-deficient mutant (rad 52) of yeast (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-05-01
    Description: The kinetic patterns of DNA synthesis in wild-type (RAD+) and rad 52 mutants of yeast, which exhibit high levels of synchrony during meiosis, are comparable. However, RAD 52 mutants accumulate single-strand breaks in parental DNA during the DNA synthesis period. Thus, the product of the RAD 52 gene has a role in meiotic DNA metabolism, as well as in the repair of DNA damage during mitotic growth. The observed breaks may be unresolved recombination intermediates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Resnick, M A -- Kasimos, J N -- Game, J C -- Braun, R J -- Roth, R M -- 5 R01 GM17317-11/GM/NIGMS NIH HHS/ -- S07-RR07027/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):543-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010606" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA Repair ; DNA, Fungal/genetics ; DNA, Single-Stranded/genetics ; Genes ; *Meiosis ; Molecular Weight ; Mutation ; *Recombination, Genetic ; Saccharomyces cerevisiae/*genetics
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  • 28
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    Early removal of one eye reduces normally occurring cell death in the remaining eye (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-31
    Description: During normal development of the hamster eye, there is a substantial loss of cells from the retinal ganglion cell layer in the first two postnatal weeks. If one eye is lost at birth, this cell death is reduced in the remaining eye. This may account for the increased ipsilateral projection from this eye to the thalamus and midbrain observed in these animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sengelaub, D R -- Finlay, B L -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):573-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244655" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Cell Survival ; Cricetinae ; Kinetics ; Neurons/*physiology ; Rats ; Retina/cytology/*physiology
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    Bee venom enhances guanylate cyclase activity (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-17
    Description: Bee venom and phospholipase A2 extracted from bee venom enhanced guanylate cyclase (E.C. 4.6.1.2) activity two- to threefold in rat liver, lung, heart, kidney, ileum, and cerebellum. Dose-response relationships revealed that bee venom at concentrations as low as 1 microgram per milliliter and phospholipase A2 at 1 microunit per milliliter caused a maximal enhancement of guanylate cyclase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vesely, D L -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):359-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6113689" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bee Venoms/*pharmacology ; Dose-Response Relationship, Drug ; Enzyme Activation ; Guanylate Cyclase/*metabolism ; Kinetics ; Organ Specificity ; Phospholipases/*pharmacology ; Phospholipases A/*pharmacology ; Phospholipases A2 ; Rats
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  • 30
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    Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-17
    Description: Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine. Denervation and hypophysectomy block the increase in medullary and cortical enzyme activity, respectively, whereas cycloheximide presents the increase in both tissues. These results provide evidence for induction and regulation of guanosine triphosphate cyclohydrolase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Viveros, O H -- Lee, C L -- Abou-Donia, M M -- Nixon, J C -- Nichol, C A -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):349-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017928" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/drug effects/*enzymology ; Adrenal Glands/innervation ; Adrenal Medulla/drug effects/*enzymology ; Aminohydrolases/*metabolism ; Animals ; Biopterin/*biosynthesis ; Cycloheximide/pharmacology ; Denervation ; GTP Cyclohydrolase/*metabolism ; Hypophysectomy ; Insulin/pharmacology ; Kinetics ; Male ; Organ Specificity ; Pteridines/*biosynthesis ; Rats ; Reserpine/pharmacology
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  • 31
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    Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-06
    Description: Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface. The putative receptor appears to mediate uptake of albumin-bound fatty acids by the cell and may account for the efficient hepatic extraction of many other substances tightly bound to albumin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisiger, R -- Gollan, J -- Ockner, R -- AM-07007/AM/NIADDK NIH HHS/ -- AM-13328/AM/NIADDK NIH HHS/ -- AM-21899/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1048-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6258226" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Fatty Acids/*metabolism ; Female ; Kinetics ; Liver/*metabolism ; Oleic Acids/metabolism ; Protein Binding ; Rats ; Receptors, Albumin ; Receptors, Cell Surface/*metabolism ; Serum Albumin/*metabolism
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    Two classes of single-stranded regions in DNA from sea urchin embryos (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-02-06
    Description: Native DNA from sea urchin embryos contains single-stranded regions (gaps) of up to 3000 nucleotides. The longer gaps (more than 1400 nucleotides) are nonrandomly distributed and are rich in histone gene sequences, other moderately repetitive sequences, and polypyrimidines. The shorter gaps are associated with DNA replication. A method for isolation of the two classes of single-stranded DNA pieces is reported.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wortzman, M S -- Baker, R F -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):588-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455698" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; *DNA Replication ; DNA, Single-Stranded/*analysis/genetics ; Genes ; Histones/*genetics ; Recombination, Genetic ; Sea Urchins/*genetics
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  • 33
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    Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-24
    Description: Nalidixic acid and novobiocin inhibit the aminoacylation and pyrophosphate exchange activities of glycyl- and leucyl-transfer RNA synthetases from bakers' yeast. Similar types of inhibition are observed for both enzymes, suggesting similar mechanisms. The potency of these inhibitors is comparable to that observed for their inhibition of in vivo DNA synthesis in eukaryotic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, H T -- Nurse, K C -- Goldstein, D J -- GM 07654/GM/NIGMS NIH HHS/ -- GM 23598/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):455-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017932" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acyl-tRNA Synthetases/*antagonists & inhibitors ; Glycine-tRNA Ligase/*antagonists & inhibitors ; Kinetics ; Leucine-tRNA Ligase/*antagonists & inhibitors ; Nalidixic Acid/*pharmacology ; Novobiocin/*pharmacology ; Oxolinic Acid/*pharmacology ; Saccharomyces cerevisiae/*enzymology
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    Mesenchymal cells from the human embryonic palate are highly responsive to epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoneda, T -- Pratt, R M -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):563-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017936" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cell Line ; DNA Replication/drug effects ; Embryo, Mammalian ; Epidermal Growth Factor/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Kinetics ; Organ Specificity ; Ornithine Decarboxylase/metabolism ; Palate/drug effects/*physiology ; Peptides/*pharmacology ; Pregnancy
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    Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Gastric acid secretion has been thought to depend on histamine stimulation of the parietal cell. However, in the 2-week-old rat neither exogenous histamine nor the H-2 receptor agonist impromidine stimulates acid secretion, whereas pentagastrin and the cholinergic agent bethanechol are potent stimuli. At this age, the effect of pentagastrin in acid secretion is not blocked by the H-2 receptor antagonist cimetidine, nor is it potentiated by impromidine. These data suggest that, in the rat pup, the acid secretory response to pentagastrin and cholinergic agents occurs before the histamine-mediated system is functional and operates independently of the actions of histamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ackerman, S H -- K1-MH00077/MH/NIMH NIH HHS/ -- R01-AM-18804/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6211765" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Bethanechol Compounds/pharmacology ; Gastric Juice/drug effects/*secretion ; Gastric Mucosa/growth & development ; Guanidines/pharmacology ; Histamine/pharmacology ; Imidazoles/pharmacology ; Impromidine ; Pentagastrin/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Histamine H2/drug effects
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    Measurement of intracellular free calcium in monkey kidney cells with aequorin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-16
    Description: A method has been developed for the measurement of intracellular free calcium in mammalian cells. The calcium-sensitive photoprotein aequorin can be incorporated into isolated cells by hypo-osmotic treatment without altering the cell viability, permeability, or metabolism. Intracellular calcium activity (Cai2+) was monitored in a perfusion system. In monkey kidney cells (LLC-MK2), Cai2+ is approximately 57 nanomoles per liter. Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+. The method has also been successfully tested in rat hepatocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borle, A B -- Snowdowne, K W -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):252-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806904" target="_blank"〉PubMed〈/a〉
    Keywords: *Aequorin ; Anaerobiosis ; Animals ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Line ; Kidney/drug effects/*metabolism ; Kinetics ; *Luminescent Proteins ; Macaca mulatta
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    Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-11
    Description: Receptors that selectively bind micromolar concentrations of benzodiazepines are present in rat brain membrane. These micromolar receptors exhibit saturable, stereospecific binding, and the potency of benzodiazepine binding to these receptors is correlated with the ability of the benzodiazepines to inhibit maximum electric shock-induced convulsions. Benzodiazepine receptors with nanomolar affinity differ from the micromolar receptors in their binding, kinetic, and pharmacologic characteristics. The micromolar receptors also bind phenytoin, a non-benzodiazepine anticonvulsant. These results provide evidence for a distinct class of clinically relevant benzodiazepine receptors that may regulate neuronal excitability and anticonvulsant activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowling, A C -- DeLorenzo, R J -- NS 1352/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1247-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281893" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism/pharmacology ; Benzodiazepinones/metabolism ; Brain/*metabolism ; Calmodulin/antagonists & inhibitors ; Diazepam/metabolism ; Kinetics ; Ligands ; Protein Kinase Inhibitors ; Rats ; Receptors, Drug/*metabolism ; Receptors, GABA-A ; Structure-Activity Relationship
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    Artificial enzymes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-11-05
    Description: Simple chemical catalysts have been designed to achieve some desirable features of enzymes. These novel catalysts are not proteins, but they may incorporate the typical enzyme catalytic groups and they achieve selectivity in their reactions by use of geometric control, as do enzymes. Catalysts that carry out geometrically controlled chlorinations of aromatic rings and steroids have been constructed. Other catalysts achieve the selective synthesis of amino acids, and still others imitate ribonuclease in detailed mechanism and hydrolyze RNA. Optimization of geometries has led to a rate acceleration of over 10(8) in one instance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, R -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):532-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123255" target="_blank"〉PubMed〈/a〉
    Keywords: Catalysis ; Cyclodextrins ; *Enzymes ; Kinetics ; Models, Chemical ; Ribonucleases ; Structure-Activity Relationship ; Substrate Specificity ; Transaminases
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    Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-08
    Description: (+/-)-N-Allylnormetazocine is a benzomorphan opioid with psychotomimetic effects. The pure stereoisomers of this compound, as well as the racemic mixture, were compared to phencyclidine for their behavioral effects on squirrel monkeys and rats trained to discriminate phencyclidine from saline. Dose-response determinations were made for responses to phencyclidine, to a racemic mixture of N-allylnormetazocine, and to the pure levo and dextro isomers of N-allylnormetazocine. In both rats and monkeys, the dextro isomer and the racemic mixture produced dose-dependent responses appropriate for phencyclidine; the levo isomer did not produce the responses appropriate for phencyclidine at any of the doses tested. In both species, the levo isomer was more potent than the dextro isomer in decreasing the rate of responding. Thus racemic N-allylnormetazocine is a mixture of compounds that produce different behavioral effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brady, K T -- Balster, R L -- May, E L -- DA-00490/DA/NIDA NIH HHS/ -- DA-01442/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274022" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Male ; Naloxone/pharmacology ; Phenazocine/*analogs & derivatives/pharmacology ; Phencyclidine/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Opioid/drug effects ; Saimiri ; Stereoisomerism ; Structure-Activity Relationship
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    Reversal of morphine disruption of maternal behavior by concurrent treatment with the opiate antagonist naloxone (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: Rats whose pregnancies were surgically terminated on day 17 of gestation were injected with morphine, morphine plus naloxone hydrochloride, or saline, and then tested for maternal responsiveness toward foster young. Morphine treatment alone significantly disrupted the rate of onset and quality of maternal responsiveness. Concurrent administration of naloxone to morphine-injected rats reinstated the rapid onset of behavioral responsiveness toward foster young, such that the responsiveness of the rats treated with both morphine and naloxone was indistinguishable from that shown by saline-injected controls. The disruptive effects of morphine did not appear to result from a general reduction in activity levels as measured in an open-field apparatus. These findings suggest that the normal onset and maintenance of maternal behavior in the rat may be regulated by endogenous opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bridges, R S -- Grimm, C T -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Drug Antagonism ; Female ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Pregnancy ; Rats ; Rats, Inbred Strains
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    Long-term synaptic potentiation in the superior cervical ganglion (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-12
    Description: Brief tetanic stimulation of the preganglionic nerves to the superior cervical ganglion enhances the postganglionic response to single preganglionic stimuli for 1 to 3 hours. This long-term potentiation of transmission through the ganglion is apparently not attributable to a persistent muscarinic action of the preganglionic neurotransmitter, acetylcholine, since neither the magnitude nor the time course of the phenomenon is reduced by atropine. The decay of long-term potentiation can be described by a first-order kinetic process with a mean time constant of 80 minutes. We conclude that long-term potentiation, once considered a unique property of the hippocampus, is in fact a more general feature of synaptic function. This form of synaptic memory may significantly influence information processing and control in other regions of the nervous system, including autonomic ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, T H -- McAfee, D A -- 12116/PHS HHS/ -- NS 16576/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ganglia, Sympathetic/*physiology ; Kinetics ; Learning/*physiology ; Neuronal Plasticity ; Rats ; Synapses/*physiology ; *Synaptic Transmission ; Time Factors
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    Ethanol in low doses augments calcium-mediated mechanisms measured intracellularly in hippocampal neurons (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-15
    Description: The electrophysiological effects of ethanol in low doses (5 to 20 millimoles per liter or 23 to 92 milligrams per 100 milliliters) were examined intracellularly in CA1 cells of rat hippocampus in vitro. Inhibitory and excitatory postsynaptic potentials were increased when ethanol was applied to the respective synaptic terminal regions. Postsynaptically, ethanol caused a moderate hyperpolarization with increased membrane conductance, even when synaptic transmission was blocked. Ethanol augmented the hyperpolarization that followed repetitive firing or that followed the eliciting of calcium spikes in the presence of tetrodotoxin, but not the rapid afterhyperpolarization in calcium-free medium. Ethanol appears to augment calcium-mediated mechanisms both pre- and postsynaptically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlen, P L -- Gurevich, N -- Durand, D -- R01 NS16660-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):306-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Electric Conductivity ; Ethanol/*pharmacology ; Hippocampus/*drug effects/physiology ; Male ; Membrane Potentials/drug effects ; Potassium/physiology ; Rats ; Rats, Inbred Strains ; Synaptic Membranes/drug effects ; Tetrodotoxin/pharmacology
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    Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-01
    Description: Studies of isolated islets labeled with radioactive leucine show that glucose at a critical time "marks" islets in such a way as to cause preferential release of newly synthesized insulin. The preferential release of insulin from marked islets is relatively independent of subsequent secretagogues or rates of insulin secretion. Previous kinetic studies have indicated that the critical time at which marking occurs is after proinsulin biosynthesis but before the secretory event. Thus, secretory cells may regulate the diversion of newly synthesized material for immediate release as it is approaching or transiting the Golgi apparatus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, G -- Gishizky, M L -- Grodsky, G M -- AM 01410/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):56-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6181562" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-3-isobutylxanthine/pharmacology ; Animals ; Glucose/*pharmacology ; In Vitro Techniques ; Insulin/biosynthesis/*secretion ; Islets of Langerhans/drug effects/*secretion ; Kinetics ; Leucine ; Potassium/pharmacology ; Tolbutamide/pharmacology
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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    Modulation of striatal dopaminergic function by local injection of 5'-N-ethylcarboxamide adenosine (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-01
    Description: Rats rotated to the left when 5'-N-ethylcarboxamide adenosine (NECA) was injected into the left caudate nucleus and apomorphine was administered subcutaneously. The combination of NECA and apomorphine was more potent than L-(phenylisopropyl)adenosine and apomorphine in eliciting rotation, suggesting the involvement of adenosine receptors of the Ra type. The response was reduced when 2',5'-dideoxyadenosine was injected along with NECA into the caudate nucleus or when theorphylline was given intraperitoneally. Higher doses of apomorphine elicited a self-mutilatory response after the injection of NECA into the caudate nucleus. These results suggest that adenosine may be involved in the modulation of dopaminergic function in the striatum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, R D -- Proudfit, H K -- Yeung, S M -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):58-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123218" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/administration & dosage/*analogs & derivatives/pharmacology ; Adenosine-5'-(N-ethylcarboxamide) ; Animals ; Apomorphine/pharmacology ; Caudate Nucleus/*physiology ; Corpus Striatum/*physiology ; Dopamine/*physiology ; Injections ; Kinetics ; Male ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Rotation ; Vasodilator Agents/*pharmacology
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    Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirsch, I R -- Morton, C C -- Nakahara, K -- Leder, P -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6801764" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocytes/*physiology ; Chromosome Mapping ; Genes ; Humans ; Immunoglobulin Heavy Chains/*genetics ; Leukemia/*genetics ; Recombination, Genetic ; Translocation, Genetic
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    Purinergic regulation of food intake (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Inosine peripherally administered to rats markedly suppressed spontaneous food intake and food intake induced by diazepam, muscimol, insulin, and food deprivation. The purines 2-deoxyguanosine and 2-deoxyinosine also suppressed food deprivation-induced feeding, whereas 7-methylinosine, which does not bind to the benzodiazepine binding site in vitro, had no effect on food intake when compared with controls. These results suggest that purines may represent endogenous substances that regulate food intake through interactions with the benzodiazepine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, A S -- Morley, J E -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/*drug effects ; Deoxyguanosine/pharmacology ; Diazepam/pharmacology ; Eating/*drug effects ; Food Deprivation ; Inosine/analogs & derivatives/pharmacology ; Insulin/pharmacology ; Male ; Muscimol/pharmacology ; Purines/*pharmacology ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship
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    Identification of the constant chromosome regions involved in human hematologic malignant disease (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-14
    Description: Specific consistent chromosome translocations are regularly observed in certain human leukemias and lymphomas. For the myeloid leukemias, the constant recombinants are: the long arm of 9 to chromosome 22 in chronic myeloid leukemia, the long arm of 21 to chromosome 8 in acute myeloblastic leukemia, and the long arm of 17 to chromosome 15 in acute promyelocytic leukemia. Three related translocations are seen in Burkitt lymphoma and B cell acute lymphocytic leukemia; in each one, chromosome 8 is involved with chromosome 2, 14, or 22. Analysis of a complex translocation affecting chromosomes 8 and 14 indicates that the translocation of chromosome 8 to chromosome 14 is the critical constant rearrangement. The analysis of the DNA at the translocation sites of these chromosomes, rather than the reciprocal of each translocation, appears to be the most productive focus for initial study. The various immunoglobulin loci are located in chromosomes 2, 14, and 22, the chromosomes regularly involved in translocations in Burkitt lymphoma and B cell acute lymphocytic leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowley, J D -- CA 16910/CA/NCI NIH HHS/ -- CA 19266/CA/NCI NIH HHS/ -- CA 25568/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 May 14;216(4547):749-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079737" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Aberrations ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 16-18 ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Genes ; Humans ; Immunoglobulins/*genetics ; Leukemia/*genetics ; Lymphoma/*genetics ; Translocation, Genetic
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    Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nekola, M B -- Horvath, A -- Ge, L J -- Coy, D H -- Schally, A V -- HD-0-2831/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):160-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750790" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Female ; Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology ; Luteinizing Hormone/secretion ; Ovulation/*drug effects ; Pregnancy ; Proestrus/drug effects ; Rats ; Rats, Inbred Strains
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    Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: Administration of the hepatic carcinogen aflatoxin B1 to experimental animals results in covalent binding to liver mitochondrial DNA at concentrations three to four times higher than nuclear DNA. The concentration of carcinogen adducts in mitochondrial DNA remains unchanged even after 24 hours, possible because of lack of excision repair. Similarly, mitochondrial transcription and translation remain inhibited up to 24 hours suggesting long-term effects of aflatoxin B1 on the mitochondrial genetic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niranjan, B G -- Bhat, N K -- Avadhani, N G -- CA-22762/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):73-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797067" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxin B1 ; Aflatoxins/*metabolism ; Animals ; DNA, Mitochondrial/*metabolism ; Kinetics ; Liver Neoplasms/*chemically induced/metabolism ; Male ; Mitochondria, Liver/*metabolism ; Neoplasms, Experimental/chemically induced ; Protein Biosynthesis/drug effects ; Rats ; Transcription, Genetic/drug effects
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    Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nieto-Sampedro, M -- Lewis, E R -- Cotman, C W -- Manthorpe, M -- Skaper, S D -- Barbin, G -- Longo, F M -- Varon, S -- AG-00538/AG/NIA NIH HHS/ -- MH-19691/MH/NIMH NIH HHS/ -- NS-16349/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):860-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100931" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/physiology ; Animals ; Brain/*physiology ; Brain Injuries/*physiopathology ; Cell Survival/drug effects ; Cells, Cultured ; Cholinergic Fibers/physiology ; Kinetics ; Nerve Growth Factors/*metabolism/pharmacology ; *Nerve Regeneration ; Rats ; Rats, Inbred Strains ; Wound Healing
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  • 52
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    Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-16
    Description: The size of the gene pool potentially encoding antibodies to p-azophenyl arsonate has been examined. A heavy chain-specific full-length complementary DNA clone has been constructed with the use of messenger RNA from a hybridoma that produces antibodies to the arsonate hapten and bears nearly a full complement of the determinants comprising the cross-reactive idiotype (CRI). The sequences of both the complementary DNA clone and the corresponding immunoglobulin heavy chain have been independently determined. A probe for the variable region gene was prepared from the original heavy chain complementary DNA clone and used to analyze, by Southern filter hybridization, genomic DNA from both A/J (CRI positive) and BALB/c (CRI negative) mice. Approximately 20 to 25 restriction fragments containing "germline" variable region gene segments were detected in both strains, and many are shared by both, Since 35 CRI-positive heavy chains have been partially sequenced thus far and 31 are different, the results of the hybridization analysis suggest that somatic mutation events involving the variable region gene segments of the heavy chain play a role in the origin of the amino acid sequence diversity seen in this system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sims, J -- Rabbitts, T H -- Estess, P -- Slaughter, C -- Tucker, P W -- Capra, J D -- A112127/PHS HHS/ -- AI-06020/AI/NIAID NIH HHS/ -- AI18016/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6801765" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites, Antibody/*genetics ; Genes ; Haptens ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Idiotypes/genetics ; Immunoglobulin Variable Region/*genetics ; Mice ; *Mutation
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  • 53
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    Norethisterone, a major ingredient of contraceptive pills, is a suicide inhibitor of estrogen biosynthesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: Norethisterone (17 alpha-ethynyl-19-nortestosterone) is an effective irreversible inhibitor of estrogen synthetase (aromatase), the enzyme responsible for the conversion of androgens to estrogens, even at a 2 X 10(-6) molar concentration. This irreversible inactivation, which is directed toward the active site of aromatase and requires the cofactor-reduced nicotinamide adenine dinucleotide phosphate, is both time- and concentration-dependent. Ethisterone (17 alpha-ethynyltestosterone), in contrast, is not a suicide inhibitor of aromatase even at concentrations of 10(-4) molar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osawa, Y -- Yarborough, C -- HDO4945/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1249-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058343" target="_blank"〉PubMed〈/a〉
    Keywords: *Aromatase Inhibitors ; Binding Sites/drug effects ; Contraceptives, Oral/*pharmacology ; Estrogens/*biosynthesis ; Female ; Humans ; Kinetics ; Microsomes/enzymology ; Norethindrone/*pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Placenta/enzymology ; Pregnancy
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    Regulation of carcinogen metabolism in the rat ovary by the estrous cycle and gonadotropin (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: The activity of 7,12-dimethylbenz[a]anthracene hydroxylase in the rat ovary is several times higher in the proestrous phase of the estrous cycle than in the estrous and metestrous plus diestrous phases. Administration of gonadotropin leads to a similar increase in the capacity of the ovary to metabolize xenobiotics. This variation in the activity of 7,12-dimethylbenz[a]anthracene hydroxylase during the estrous cycle may be related to the marked changes in the incidence of ovarian cancer during menopause and in women taking contraceptive pills.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bengtsson, M -- Rydstrom, J -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681915" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/*metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Epoxide Hydrolases/metabolism ; *Estrus ; Female ; Glutathione Transferase/metabolism ; Gonadotropins, Equine/*pharmacology ; Metestrus ; Ovary/*physiology ; Pregnancy ; Proestrus ; Quinone Reductases/metabolism ; Rats ; Rats, Inbred Strains
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    Translational efficiency of transfer RNA's: uses of an extended anticodon (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. the anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yarus, M -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):646-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753149" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Escherichia coli/genetics ; Kinetics ; Nucleic Acid Conformation ; *Protein Biosynthesis ; RNA, Transfer/*genetics ; Ribosomes/metabolism ; Structure-Activity Relationship ; Suppression, Genetic
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  • 56
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    Time course of alpha-flupenthixol action explains "response artifacts" of neuroleptic action on brain stimulation reward (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 16;222(4629):1251-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Flupenthixol/*pharmacology ; Hypothalamus/*drug effects ; Kinetics ; Rats ; *Reward ; Self Stimulation/*drug effects ; Thioxanthenes/*pharmacology
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    Pimozide blocks establishment but not expression of amphetamine-produced environment-specific conditioning (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-17
    Description: Animals with a history of receiving daily injections of +-amphetamine in a specific environment showed a placebo effect (enhanced activity) when injected with saline and placed there; control animals with similar but dissociated drug histories and experience with the test chamber failed to show the effect. The dopamine receptor blocker pimozide antagonized the establishment of conditioning. However, the same dose of pimozide, when given to previously conditioned animals on the placebo test day, failed to antagonize the expression of conditioned activity. Thus, during conditioning dopaminergic neurons mediated a change that subsequently influenced behavior even when dopaminergic systems were blocked. Although schizophrenia may be related to hyperfunctioning of dopamine, neuroleptic drugs, which block dopamine receptors on their first administration, do not have therapeutic effects for a number of days. The results of the pimozide experiments may resolve this paradox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beninger, R J -- Hahn, B L -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology)/*drug effects/physiology ; Dextroamphetamine/antagonists & inhibitors/*pharmacology ; Humans ; Male ; Pimozide/*pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/physiology ; Reinforcement (Psychology) ; Schizophrenia/physiopathology
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    Splice junctions: association with variation in protein structure (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: A comparison between eukaryotic gene sequences and protein sequences of homologous enzymes from bacterial and mammalian organisms shows that intron-exon junctions frequently coincide with variable surface loops of the protein structures. The altered surface structures can account for functional differences among the members of a family. Sliding of the intron-exon junctions may constitute one mechanism for generating length polymorphisms and divergent sequences found in protein families. Since intron-exon junctions map to protein surfaces, the alterations mediated by sliding of these junctions can be effected without disrupting the stability of the protein core.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Craik, C S -- Rutter, W J -- Fletterick, R -- AM21344/AM/NIADDK NIH HHS/ -- AM26081/AM/NIADDK NIH HHS/ -- GM28520/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1125-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344214" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Bacterial Proteins ; Base Sequence ; Biological Evolution ; DNA/genetics ; Endopeptidases/genetics ; Eukaryotic Cells/metabolism ; Genes ; Genes, Bacterial ; Protein Conformation ; Proteins/*genetics ; *Serine Endopeptidases ; Tetrahydrofolate Dehydrogenase/genetics
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    Direct in vivo monitoring of dopamine released from two striatal compartments in the rat (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: Microvoltammetric electrodes were used to monitor dopamine released in the caudate nucleus of the rat after electrical stimulation of the medial forebrain bundle. The time resolution of the technique is sufficient to determine in vivo concentration changes on a time scale of seconds. Direct evidence identifying the substance released as dopamine was obtained both voltammetrically and pharmacologically. Administration of alpha-methyl-p-tyrosine terminates the release of dopamine, although tissue stores of dopamine are still present. Thus there appears to be a compartment for dopamine storage that is not available for immediate release. This compartment appears to be mobilized by amfonelic acid, since administration of this agent after alpha-methyl-p-tyrosine returns the concentration of dopamine released by electrical stimulation to 75 percent of the original amount.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ewing, A G -- Bigelow, J C -- Wightman, R M -- KO 4 NS000356/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):169-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857277" target="_blank"〉PubMed〈/a〉
    Keywords: Amphetamine/pharmacology ; Animals ; Caudate Nucleus/drug effects/*metabolism ; Dopamine/*metabolism ; Male ; Methyltyrosines/pharmacology ; Microelectrodes ; Naphthyridines/pharmacology ; Rats ; Rats, Inbred Strains ; alpha-Methyltyrosine
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    Scientist sues over genetically impure mice (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
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    Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R R -- Kuhar, M J -- Hester, L -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 27;220(4600):967-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302841" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*physiology ; Animals ; Autoradiography ; Axons/*physiology ; Cerebellum/physiology ; Corpus Striatum/physiology ; Hippocampus/physiology ; Mice ; Mice, Neurologic Mutants ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*physiology ; Receptors, Purinergic ; Retinal Ganglion Cells/physiology ; Synaptic Membranes/physiology ; Thalamus/physiology
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    Midbrain microinfusions of prolactin increase the estrogen-dependent behavior, lordosis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Microinfusions of rat prolactin into the dorsal midbrain of estrogen-treated, ovariectomized rats increased lordosis behavior. Midbrain microinfusions of antiserum to prolactin into rats displaying maximum lordosis had the opposite effect. The distribution of a prolactin-like substance in the brain was studied immunocytochemically. The results suggest that a hypothalamic neuronal system projecting to the midbrain contains a prolactin-like substance that plays a role in facilitating this behavior and therefore may mediate some of the effects of estrogen on the brain. These data, together with others from studies of the prolactin gene and its regulation, indicate that it may be possible to analyze a sequence of molecular events in the brain that facilitate a behavioral response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harlan, R E -- Shivers, B D -- Pfaff, D W -- HD-05585/HD/NICHD NIH HHS/ -- HD-05737/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828874" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Castration ; Cerebral Cortex/drug effects/*physiology ; Cosyntropin/pharmacology ; Estradiol/pharmacology ; Female ; Growth Hormone/pharmacology ; Immune Sera ; Kinetics ; Mesencephalon/*physiology ; Oxytocin/pharmacology ; Posture ; Prolactin/administration & dosage/*pharmacology ; Rats ; Sexual Behavior, Animal/*drug effects ; Vasopressins/pharmacology
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  • 63
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    The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-12-23
    Description: Endotoxin-free thymosin fraction 5 elevated corticotropin, beta-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides of thymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy of juvenile macaques was associated with decreases in plasma cortisol, corticotropin, and beta-endorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Healy, D L -- Hodgen, G D -- Schulte, H M -- Chrousos, G P -- Loriaux, D L -- Hall, N R -- Goldstein, A L -- CA 24974/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1353-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318312" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*blood ; Animals ; Dose-Response Relationship, Drug ; Endorphins/blood ; Female ; Hydrocortisone/blood ; Kinetics ; Macaca fascicularis ; Thymectomy ; Thymosin/analogs & derivatives/*pharmacology ; Thymus Gland/*physiology ; beta-Endorphin
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    Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: Long-term treatment of rats with atropine induced large increases in the numbers of muscarinic receptors and receptors for vasoactive intestinal polypeptide in the salivary glands. Since receptors for vasoactive intestinal polypeptide coexist with muscarinic receptors on the same neurons in this preparation, the results suggest that a drug that alters the sensitivity of one receptor may also affect the sensitivity of the receptor for a costored transmitter and in this way contribute to the therapeutic or side effects of the drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedlund, B -- Abens, J -- Bartfai, T -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):519-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132446" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/*pharmacology ; Gastrointestinal Hormones/*metabolism ; Male ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*drug effects ; Receptors, Muscarinic/analysis/*drug effects ; Salivary Glands/analysis/innervation ; Vasoactive Intestinal Peptide/analysis/*metabolism
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    Implication of nonlinear kinetics on risk estimation in carcinogenesis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-04
    Description: Efforts in estimating carcinogenic risk in humans from long-term exposure to chemical carcinogens have centered on the problem of low-dose extrapolation. For chemicals with metabolites that interact with DNA, it may be more meaningful to relate tumor response to the concentration of the DNA adducts in the target organ rather than to the applied dose. Many data suggest that the relation between tumor response and concentration of DNA adducts in the target organ may be linear. This implies that the nonlinearities of the dose-response curve for tumor induction may be due to the kinetic processes involved in the formation of carcinogen metabolite--DNA adducts. Of particular importance is the possibility that the kinetic processes may show a nonlinear "hockey-stick" like behavior which results from saturation of detoxification or DNA repair processes. The mathematical models typically used for low-dose extrapolation are shown potentially to overestimate risk by several orders of magnitude when nonlinear kinetics are present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoel, D G -- Kaplan, N L -- Anderson, M W -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1032-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823565" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens/*administration & dosage ; Cell Transformation, Neoplastic/*drug effects ; DNA, Neoplasm/genetics ; Dose-Response Relationship, Drug ; Humans ; Kinetics ; Models, Biological ; Neoplasms/*chemically induced ; Risk
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    Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Honchar, M P -- Olney, J W -- Sherman, W R -- MH-14677/MH/NIMH NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- NS-05159/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301005" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/pharmacology ; Brain Chemistry/drug effects ; Chlorides/adverse effects ; Drug Interactions ; Humans ; Inositol/analogs & derivatives/analysis ; *Inositol Phosphates ; Lithium/*adverse effects ; Lithium Chloride ; Male ; Parasympathomimetics/*adverse effects ; Physostigmine/adverse effects ; Pilocarpine/adverse effects ; Rats ; Rats, Inbred Strains ; Seizures/*chemically induced ; Substance-Related Disorders/*etiology
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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    Myoglobin gene is a big surprise. The first analysis of a myoglobin gene reveals some striking similarities and some unexpected differences from hemoglobin genes (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1312.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828858" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Genes ; Humans ; Myoglobin/*genetics
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    Heme-heme orientation and electron transfer kinetic behavior of multisite oxidation-reduction enzymes (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-11-25
    Description: Analysis of the polarized single-crystal absorption spectra of cytochrome cd1 of Pseudomonas aeruginosa shows that the heme c and heme d1 groups in each subunit are oriented perpendicularly to each other in both oxidized and reduced forms of the enzyme. These results, together with those of previous kinetic studies, indicate that a perpendicular heme-heme orientation may be an important factor in specifying kinetically slow steps in a sequential series of electron transfer reactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makinen, M W -- Schichman, S A -- Hill, S C -- Gray, H B -- 1-T32-HD-07009/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):929-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6415814" target="_blank"〉PubMed〈/a〉
    Keywords: *Cytochromes ; *Electron Transport ; *Heme ; Kinetics ; *Nitrite Reductases ; Pseudomonas aeruginosa/enzymology ; Spectrum Analysis
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    Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-11-25
    Description: Intracisternal injection of ovine corticotropin-releasing factor (CRF) into the pylorus-ligated rat or the rat with gastric fistula resulted in a dose-dependent inhibition of gastric secretion stimulated with pentagastrin or thyrotropin-releasing hormone. When injected into the lateral hypothalamus--but not when injected into the cerebral cortex--CRF suppressed pentagastrin-stimulated acid secretion. The inhibitory effect of CRF was blocked by vagotomy and adrenalectomy but not by hypophysectomy or naloxone treatment. These results indicate that CRF acts within the brain to inhibit gastric acid secretion through vagal and adrenal mechanisms and not through hypophysiotropic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tache, Y -- Goto, Y -- Gunion, M W -- Vale, W -- River, J -- Brown, M -- AM30110/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):935-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6415815" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Brain/*drug effects ; Cerebral Cortex/drug effects ; Corticotropin-Releasing Hormone/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Gastric Acid/*secretion ; Hypophysectomy ; Hypothalamus/drug effects ; Male ; Pentagastrin/antagonists & inhibitors ; Rats ; Rats, Inbred Strains ; Thyrotropin-Releasing Hormone/antagonists & inhibitors ; Vagotomy
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    Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-01
    Description: Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tannenbaum, G S -- Guyda, H J -- Posner, B I -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Weight/*drug effects ; Brain/drug effects/*physiology ; Eating/drug effects ; Growth Hormone/antagonists & inhibitors/blood/*physiology ; Insulin/blood/*pharmacology ; Male ; Peptides/*pharmacology ; Rats ; Rats, Inbred Strains ; Somatomedins/*pharmacology
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    Monoclonal antibodies reveal the structural basis of antibody diversity (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-11-18
    Description: Hybridoma technology has made it possible to introduce into continuous culture normal antibody-forming cells and to obtain large amounts of the immunoglobulin produced by each of these cells. Examination of the structure of a number of monoclonal antibodies that react with a single antigen has provided new information on the structural basis of the specificity and affinity of antibodies. Comparisons of families of monoclonal antibodies derived from a single germ line gene revealed the importance of somatic mutation in generating antibody diversity. Monoclonal antibodies that react with variable regions of other monoclonals allow the further dissection and modulation of the immune response. Finally, the continued somatic instability of immunoglobulin genes in cultured antibody-forming cells makes it possible to determine the rate of somatic mutation and to generate mutant monoclonal antibodies that may be more effective serological reagents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teillaud, J L -- Desaymard, C -- Giusti, A M -- Haseltine, B -- Pollock, R R -- Yelton, D E -- Zack, D J -- Scharff, M D -- 5T32GM7288/GM/NIGMS NIH HHS/ -- AI05231/AI/NIAID NIH HHS/ -- AI10702/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):721-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6356353" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/genetics/*immunology ; *Antibody Diversity ; Antibody Specificity ; Genes ; Hybridomas/immunology ; Immunoglobulin Idiotypes/immunology ; Immunoglobulin Variable Region/genetics ; Mice ; Mutation ; Protein Conformation ; Structure-Activity Relationship
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    Protein engineering (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-02-11
    Description: The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modelling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene synthesis. Such techniques offer the potential for altering protein structure and function in ways not possible by any other method.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ulmer, K M -- New York, N.Y. -- Science. 1983 Feb 11;219(4585):666-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6572017" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Crystallography ; Genes ; *Genetic Engineering ; Models, Molecular ; Molecular Biology/trends ; Protein Conformation ; Proteins/*genetics ; X-Ray Diffraction
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    Potent interaction between glucocorticoids and growth hormone-releasing factor in vivo (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-05
    Description: Administration of dexamethasone significantly enhanced the pituitary growth hormone response to growth hormone-releasing factor in intact as well as adrenalectomized rats. Thus the inhibitory effects of glucocorticosteroids on somatic growth which involve an interaction of these steroids and growth hormone at a peripheral level may also involve a modification of pathways within the central nervous system that regulate normal growth hormone secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehrenberg, W B -- Baird, A -- Ling, N -- AM-18811/AM/NIADDK NIH HHS/ -- HD 09690/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):556-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408735" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Dexamethasone/pharmacology ; Drug Interactions ; Glucocorticoids/*pharmacology ; Growth Hormone/blood/secretion ; Growth Hormone-Releasing Hormone/*pharmacology ; Male ; Rats ; Rats, Inbred Strains
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    Waterlogged molecules (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-12-09
    Description: Measurements of vapor pressures over their aqueous solutions indicate that organic compounds show profound differences in hydrophilic character. These differences are of such magnitude as to suggest an important role for changing solvation in determining free energy changes associated with metabolic transformations in water, and in governing structural equilibria of proteins and other large molecules in water. When two or more functional groups are present within the same solute molecule, their combined effects on its free energy of solvation are commonly additive. Striking departures from additivity, observed in certain cases, indicate the existence of special interactions between different parts of a solute molecule and the water that surrounds it. Similar considerations presumably apply to activated intermediates in the interconversion of biological materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfenden, R -- GM 18325/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1087-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6359416" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Organic ; Enzymes/physiology ; Kinetics ; Metabolism ; Nucleic Acid Conformation ; Nucleic Acids/physiology ; Organic Chemistry Phenomena ; Protein Conformation ; Solvents ; Water/*physiology
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    Noninvasive observations of fluorinated anesthetics in rabbit brain by fluorine-19 nuclear magnetic resonance (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-28
    Description: Fluorinated anesthetics were observed noninvasively in the brain of intact rabbits with fluorine-19 nuclear magnetic resonance spectroscopy. High-resolution fluorine-19 spectra of halothane, methoxyflurane, and isoflurane were obtained with a surface coil centered over the calvarium. Elimination of halothane from the brain was also monitored by this technique. Residual fluorine-19 signals from halothane (or a metabolite) could be detected as long as 98 hours after termination of anesthesia. These observations demonstrate the feasibility of using this technique to study the fate of fluorinated anesthetics in live mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyrwicz, A M -- Pszenny, M H -- Schofield, J C -- Tillman, P C -- Gordon, R E -- Martin, P A -- GM 29520/GM/NIGMS NIH HHS/ -- K04 GM 00503/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):428-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623084" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Halothane/*metabolism ; Isoflurane/*metabolism ; Kinetics ; Magnetic Resonance Spectroscopy ; Methoxyflurane/*metabolism ; Methyl Ethers/*metabolism ; Rabbits
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    Increased brain size and cellular content in infant rats treated with an opiate antagonist (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-16
    Description: From birth to day 21, rat offspring received daily injections of naltrexone at a dosage that blocked morphine-induced analgesia 24 hours a day. At 21 days, body, brain, and cerebellar weights of naltrexone-injected animals were 18, 11, and 5 percent greater than corresponding control weights. In addition, morphometric analysis of the cerebrum revealed a somatosensory cortex that was 18 percent thicker than that of the controls. The cerebellum of naltrexone-treated rats was 41 percent larger in total area and contained at least 70 percent more glial cells and 30 percent more granule neurons. Neurons derived prenatally were unaffected by drug treatment. These results show that naltrexone can stimulate body and brain growth in rats and suggest a role for the endorphin and opiate receptor system in development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zagon, I S -- McLaughlin, P J -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1179-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612331" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Body Weight/drug effects ; Brain/*drug effects/growth & development/ultrastructure ; Cerebellum/drug effects ; Morphine/*antagonists & inhibitors ; Naloxone/*analogs & derivatives ; Naltrexone/*pharmacology ; Neuroglia/drug effects ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; Somatosensory Cortex/drug effects
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    Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-03-23
    Description: Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altura, B M -- Altura, B T -- Gebrewold, A -- Ising, H -- Gunther, T -- HL18015/HL/NHLBI NIH HHS/ -- HL29600/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701524" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arterioles/pathology ; *Blood Pressure ; Capillaries/pathology ; Magnesium/blood ; Magnesium Deficiency/pathology/*physiopathology ; Male ; *Microcirculation ; Rats ; Rats, Inbred Strains ; *Vasoconstriction ; Venules/pathology
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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    Inhibition of aldosterone production by an atrial extract (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: Crude extracts of rat atria reduced the basal amount of aldosterone released from rat zona glomerulosa cells and partially inhibited aldosterone stimulation by adrenocorticotropic hormone and angiotensin II. The destruction of this activity by trypsin suggests that the active factor is a peptide, possibly atrial natriuretic factor. These data suggest that atrial natriuretic factor affects sodium excretion by the kidneys both directly and through the inhibition of aldosterone production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Atarashi, K -- Mulrow, P J -- Franco-Saenz, R -- Snajdar, R -- Rapp, J -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):992-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326267" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/pharmacology ; Aldosterone/*biosynthesis ; Angiotensin II/pharmacology ; Animals ; *Atrial Function ; Dogs ; Female ; Kidney/drug effects/metabolism ; Mineralocorticoid Receptor Antagonists/pharmacology ; Natriuresis/drug effects ; Rats ; Rats, Inbred Strains ; Trypsin/pharmacology
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  • 81
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    Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: A T lymphotropic virus found in patients with the acquired immune deficiency syndrome (AIDS) or lymphadenopathy syndrome has been postulated to be the cause of AIDS. Immunological analysis of this retrovirus and its biological properties suggest that it is a member of the family of human T-lymphotropic retroviruses known as HTLV. Accordingly, it has been named HTLV-III. In the present report it is shown by nucleic acid hybridization that sequences of the genome of HTLV-III are homologous to the structural genes (gag, pol, and env) of both HTLV-I and HTLV-II and to a potential coding region called pX located between the env gene and the long terminal repeating sequence that is unique to the HTLV family of retroviruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arya, S K -- Gallo, R C -- Hahn, B H -- Shaw, G M -- Popovic, M -- Salahuddin, S Z -- Wong-Staal, F -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):927-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089333" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Base Sequence ; Cloning, Molecular ; Dna ; DNA, Viral ; Deltaretrovirus/classification/*genetics ; Genes ; *Genes, Viral ; Humans ; *Nucleic Acid Hybridization ; RNA, Viral ; Repetitive Sequences, Nucleic Acid
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  • 82
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    Fast and slow magnetic phenomena in focal epileptic seizures (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-16
    Description: The magnetic fields associated with penicillin-induced focal epilepsy were measured in laboratory rats. Interictal magnetic spikes were similar to those previously observed in humans with focal seizure disorders. The magnetic fields of the seizure itself displayed both slow and fast phenomena, reversing in direction on opposite sides of the head.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barth, D S -- Sutherling, W -- Beatty, J -- 1-R01-NS20806-01/NS/NINDS NIH HHS/ -- 1K07NS00678-01A1/NS/NINDS NIH HHS/ -- 5-S07 RR07009/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):855-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436979" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electroencephalography ; *Electromagnetic Fields ; *Electromagnetic Phenomena ; Electrophysiology ; Epilepsies, Partial/*physiopathology ; Humans ; Penicillins/pharmacology ; Rats ; Rats, Inbred Strains ; Seizures/physiopathology
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  • 83
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    Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baekkeskov, S -- Dyrberg, T -- Lernmark, A -- AM26190/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1348-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6374896" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantibodies/*immunology ; Diabetes Mellitus, Experimental/*immunology ; Diabetes Mellitus, Type 1/immunology ; Humans ; Islets of Langerhans/*immunology ; Rats ; Rats, Inbred Strains ; Rats, Mutant Strains
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  • 84
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    Interrelated striated elements in vestibular hair cells of the rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Unusual fixation procedures revealed a series of interrelated striated organelles in type I and type II vestibular hair cells of the rat; these organelles seemed to be less well developed in cochlear hair cells. The findings suggest that contractile elements may play a role in sensory transduction in the inner ear, particularly in the vestibular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, M D -- Bourne, C -- New York, N.Y. -- Science. 1983 May 6;220(4597):622-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682246" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/physiology ; Animals ; Cell Membrane/ultrastructure ; Cytoskeleton/ultrastructure ; Hair Cells, Auditory/*ultrastructure ; Microscopy, Electron ; Organoids/ultrastructure ; Rats ; Rats, Inbred Strains
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  • 85
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 86
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    Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-08
    Description: Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase inhibitor diisopropyl fluorophosphate, binding of tritiated acetylcholine in the cerebral cortex was decreased. However, after repeated administration of nicotine for 10 days, binding of tritiated acetylcholine in the cortex was increased. Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, R D -- Kellar, K J -- 507 RR05360-20/RR/NCRR NIH HHS/ -- GM07443/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):214-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828889" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Animals ; Brain/*physiology ; Brain Chemistry/drug effects ; Cerebral Cortex/analysis/physiology ; Isoflurophate/pharmacology ; Male ; Nicotine/metabolism/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*physiology ; Receptors, Nicotinic/analysis/*physiology
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  • 87
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    Optical measurements of extracellular calcium depletion during a single heartbeat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-12
    Description: The impermeant dye antipyrylazo III was used to measure depletion of extracellular calcium and net influx of calcium through the sarcolemma during the cardiac action potential. It was found that calcium entry occurs continuously during the action potential and is under direct control of the membrane potential. The inotropic action of epinephrine is accompanied by increased influx of calcium, while strophanthidin enhances the twitch without altering calcium influx during the action potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cleemann, L -- Pizarro, G -- Morad, M -- HL16152/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):174-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6091269" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Calcium/*metabolism ; Epinephrine/pharmacology ; Extracellular Space/*metabolism ; Ion Channels ; Kinetics ; *Myocardial Contraction/drug effects ; Myocardium/*metabolism ; Naphthalenesulfonates ; Ranidae ; Sarcolemma/*metabolism ; Spectrophotometry ; Stimulation, Chemical ; Strophanthidin/pharmacology
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  • 88
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    Rapid degradation of "new" acetylcholine receptors at neuromuscular junctions (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-10-07
    Description: Acetylcholine receptors at innervated neuromuscular junctions are very stable, with half-lives reported to be 6 to 13 days. Their turnover is described as a first-order process, implying a single population of receptors. In this study, two subpopulations of acetylcholine receptors at normally innervated junctions have been identified. One has a rapid turnover rate with a half-life of 18.7 hours, similar to that of extrajunctional receptors, and the other has a slow turnover rate with a half-life of 12.4 days. The rapidly turned over subpopulation represents approximately 20 percent of the total junctional receptors. This finding may account for the discrepancies in previous reports of turnover rates and may explain the rapid reversibility in vivo of agents that "irreversibly" block acetylcholine receptors. This finding also implies that the synthesis rate of junctional acetylcholine receptors may be higher than previous estimates. The rapidly turned-over subpopulation may represent receptors that were newly inserted into the neuromuscular junction and that were not yet stabilized by an influence of the motor nerve.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, E F -- Drachman, D B -- 5 P01 NS10920/NS/NINDS NIH HHS/ -- 5 R01 HD04817/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623057" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bungarotoxins ; Diaphragm ; Kinetics ; Mice ; Neuromuscular Junction/*metabolism ; Receptors, Cholinergic/biosynthesis/classification/*metabolism ; Synaptic Membranes/metabolism
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  • 89
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    Genes of the major histocompatibility complex in mouse and man (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-11-18
    Description: The genes of the major histocompatibility complex code for cell-surface molecules that play an important role in the generation of the immune response. These genes and molecules have been studied intensively over the last five decades by geneticists, biochemists, and immunologists, but only recently has the isolation of the genes by molecular biologists facilitated their precise characterization. Many surprising findings have been made concerning their structure, multiplicity, organization, function, and evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinmetz, M -- Hood, L -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):727-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6356354" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Chromosome Mapping ; Genes ; H-2 Antigens/*genetics ; HLA Antigens/*genetics ; Histocompatibility Antigens/genetics ; Humans ; *Major Histocompatibility Complex ; Mice ; Polymorphism, Genetic ; Protein Conformation
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  • 90
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    Decreased neuronal inhibition in vitro after long-term administration of ethanol (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-06-22
    Description: The pathophysiology of brain dysfunction was studied with an animal model of chronic alcoholism. Rats were fed a liquid diet with or without ethanol for 20 weeks and then the diet without ethanol for three more weeks. Hippocampal slices were prepared and intracellular recordings were obtained from dentate granule and CA1 cells. Significant depression of orthodromically elicited inhibitory postsynaptic potentials and postspike afterhyperpolarizations was observed in neurons from ethanol-exposed animals. No differences were observed in other active or passive membrane characteristics. These results suggest that a loss of neuronal inhibition could contribute to brain dysfunction in chronic alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Durand, D -- Carlen, P L -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1359-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328654" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Alcoholism/physiopathology ; Animals ; Calcium/physiology ; Ethanol/*pharmacology ; Humans ; Ion Channels/drug effects ; Male ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Rats ; Rats, Inbred Strains
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  • 91
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 92
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    Chemical mutation of enzyme active sites (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-02
    Description: New active sites can be introduced into naturally occurring enzymes by the chemical modification of specific amino acid residues with the use of appropriately designed coenzyme analogs. The resultant semisynthetic enzymes can have catalytic activities very different from those of the corresponding native enzymes. For example, papain has been converted into a highly effective oxidoreductase by covalent modification of the sulfhydryl group of the active site cysteine residue (Cys25) with flavins such as 8-bromoacetyl-10-methylisoalloxazine. Thus, it is now possible to enhance the catalytic versatility of existing enzymes through the process of "chemical mutation" of the active site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Lawrence, D S -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):505-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6238407" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis ; *Binding Sites ; Catalysis ; Chemical Phenomena ; *Chemistry ; Chymotrypsin ; Enzymes/*chemical synthesis ; Flavins ; Kinetics ; NAD/metabolism ; Niacinamide/analogs & derivatives ; Oxidation-Reduction ; Papain ; Stereoisomerism ; Toluene/analogs & derivatives/metabolism
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  • 93
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    Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-08-03
    Description: Apolipoproteins A-1 and A-2 were purified from human plasma. At concentrations present in human bile these proteins prolonged the nucleation time of cholesterol monohydrate crystals when added to model systems of supersaturated bile. In contrast, apolipoprotein C-3 and other serum proteins did not have this effect. Also, when human gallbladder bile was fractionated by gel filtration chromatography, apolipoproteins A-1 and A-2 were among the proteins present in a fraction of bile enriched in potent inhibitors of cholesterol crystal nucleation. These findings suggest that apolipoproteins A-1 and A-2 in supersaturated human gallbladder bile could inhibit the rate of formation of solid cholesterol crystals and thus help to prevent spontaneous cholesterol gallstone formation in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kibe, A -- Holzbach, R T -- LaRusso, N F -- Mao, S J -- AM-17562/AM/NIADDK NIH HHS/ -- AM-24031/AM/NIADDK NIH HHS/ -- HL-32317/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6429856" target="_blank"〉PubMed〈/a〉
    Keywords: Apolipoprotein A-I ; Apolipoprotein A-II ; Apolipoproteins/*blood ; Bile/*physiology ; Cholesterol/*metabolism ; Crystallization ; Gallbladder/physiology ; Humans ; Kinetics ; Lipoproteins, HDL/*blood ; Models, Biological
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  • 94
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    Intrahippocampal septal grafts ameliorate learning impairments in aged rats (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-08-03
    Description: Grafts of fetal septal tissue rich in cholinergic neurons were implanted as a dissociated cell suspension into the depth of the hippocampal formation in aged rats with severe impairments in spatial learning abilities. After 2 1/2 to 3 months, the rats with grafts, but not the controls, had improved their performance in a spatial learning test. Their improvement was due, at least in part, to an increased ability to use spatial cues in the task. In all animals the grafts had produced an extensive acetylcholinesterase-positive terminal network in the surrounding host hippocampal formation. Thus, the action of cholinergic neurons in the graft onto elements in the host hippocampal circuitry may be a necessary, but perhaps not sufficient, prerequisite for the observed functional recovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gage, F H -- Bjorklund, A -- Stenevi, U -- Dunnett, S B -- Kelly, P A -- AG 03766/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):533-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6539949" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Disease Models, Animal ; Female ; Fetus ; Hippocampus/embryology/growth & development/*transplantation ; Humans ; *Learning ; Memory Disorders/*physiopathology ; Rats ; Rats, Inbred Strains
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  • 95
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    Isolation and culture of a tetraploid subpopulation of smooth muscle cells from the normal rat aorta (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: Smooth muscle cells with 4C (double diploid) DNA content have been found in major arteries. The proportion of 4C cells increases with normal aging and with hypertension. These cells may represent a state of arrest at the G2 phase of the cell cycle or may be examples of true tetraploidy. Flow cytometric cell sorting was used to isolate 4C smooth muscle cells from the rat aorta, and the cells were cultured. Flow cytometry, Feulgen microdensitometry, and karyotyping of the progeny of the 4C cells established the presence of true tetraploid cells. These findings demonstrate the presence of reproductively viable tetraploid cells in a normal mammalian tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, I D -- Rosen, E M -- Shapiro, H M -- Zoller, L C -- Myrick, K -- Levenson, S E -- Christenson, L -- 5-P01-CA-12662/CA/NCI NIH HHS/ -- AG00599/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494901" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta, Thoracic/analysis/*cytology ; Cells, Cultured ; DNA/analysis ; Flow Cytometry ; Humans ; Karyotyping ; Muscle, Smooth, Vascular/analysis/*cytology ; *Polyploidy ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 96
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    A major human histone gene cluster on the long arm of chromosome 1 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: A human histone gene cluster was assigned to chromosome 1 by Southern blot analysis of DNA's from a series of mouse-human somatic cell hybrids with 32P-labeled cloned human H4 and H3 histone DNA as probes. Localization of this histone gene cluster on the long arm of chromosome 1 was confirmed by in situ hybridization of this DNA probe to metaphase chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, L -- Van Antwerpen, R -- Stein, J -- Stein, G -- Tripputi, P -- Emanuel, B -- Selden, J -- Croce, C -- GM20138/GM/NIGMS NIH HHS/ -- GM20700/GM/NIGMS NIH HHS/ -- GM32010/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):838-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494913" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosome Mapping ; *Chromosomes, Human, 1-3 ; Chromosomes, Human, 6-12 and X ; DNA/metabolism ; Genes ; Histones/*genetics ; Humans ; Hybrid Cells/metabolism ; Mice ; Nucleic Acid Hybridization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-10
    Description: Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lau, H -- Reemtsma, K -- Hardy, M A -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):607-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6420888" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Survival/radiation effects ; Dose-Response Relationship, Radiation ; Islets of Langerhans/radiation effects ; *Islets of Langerhans Transplantation ; Kinetics ; Rats ; Rats, Inbred Lew ; Transplantation, Homologous ; Transplantation, Isogeneic ; *Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Influence of spaceflight on erythrokinetics in man (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-13
    Description: A significant postflight reduction in the circulating red cell mass has been observed in both the American and Soviet manned programs. The mechanism and etiology of this loss were studied in blood samples from the four payload crewmen of Spacelab 1 taken before, during, and after flight. These samples and samples from control groups on the ground were analyzed for selected hematological and biochemical parameters, which were chosen on the basis of data previously collected, the restraints imposed by the use of human subjects, and the guidelines established for the first Spacelab mission. Twenty-two hours after weightless exposure, there was an increase in hemoglobin and hematocrit. On day 7 in flight, the hemoglobin and hematocrit remained high and there was a slight decrease in reticulocyte number. On landing, red cell mass, plasma volume, hematocrit, and reticulocyte number were decreased. Throughout the 2-week postflight sampling period, hemoglobin, hematocrit, and reticulocyte number remained below the preflight value. Since this crew was not exposed to 100 percent oxygen these results are viewed as evidence that other spaceflight factors cause the measured red cell mass reduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leach, C S -- Johnson, P C -- New York, N.Y. -- Science. 1984 Jul 13;225(4658):216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729477" target="_blank"〉PubMed〈/a〉
    Keywords: Erythrocyte Count ; Erythrocyte Volume ; Erythrocytes/*physiology ; Erythropoiesis ; Erythropoietin/blood ; Hematocrit ; Hemoglobins/analysis ; Humans ; Kinetics ; Reticulocytes ; *Space Flight
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-17
    Description: Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, J D -- Lau, W -- Kwiat, G -- Goetzl, E J -- AM 32634/AM/NIADDK NIH HHS/ -- DE 05369/DE/NIDCR NIH HHS/ -- HL 31809/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):743-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6087456" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics/*pharmacology ; Animals ; Bradykinin/pharmacology ; Dinoprostone ; Indomethacin/pharmacology ; Leukotriene B4/analogs & derivatives/*pharmacology ; Male ; Neutrophils/*drug effects/physiology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandins E/pharmacology ; Rats ; Rats, Inbred Strains ; SRS-A/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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