Publication Date:
1981-07-17
Description:
Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine. Denervation and hypophysectomy block the increase in medullary and cortical enzyme activity, respectively, whereas cycloheximide presents the increase in both tissues. These results provide evidence for induction and regulation of guanosine triphosphate cyclohydrolase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Viveros, O H -- Lee, C L -- Abou-Donia, M M -- Nixon, J C -- Nichol, C A -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):349-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017928" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenal Cortex/drug effects/*enzymology
;
Adrenal Glands/innervation
;
Adrenal Medulla/drug effects/*enzymology
;
Aminohydrolases/*metabolism
;
Animals
;
Biopterin/*biosynthesis
;
Cycloheximide/pharmacology
;
Denervation
;
GTP Cyclohydrolase/*metabolism
;
Hypophysectomy
;
Insulin/pharmacology
;
Kinetics
;
Male
;
Organ Specificity
;
Pteridines/*biosynthesis
;
Rats
;
Reserpine/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
