Publication Date:
1985-06-28
Description:
The functional organization of the mammalian myelinated nerve fiber is complex and elegant. In contrast to nonmyelinated axons, whose membranes have a relatively uniform structure, the mammalian myelinated axon exhibits a high degree of regional specialization that extends to the location of voltage-dependent ion channels within the axon membrane. Sodium and potassium channels are segregated into complementary membrane domains, with a distribution reflecting that of the overlying Schwann or glial cells. This complexity of organization has important implications for physiology and pathophysiology, particularly with respect to the development of myelinated fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waxman, S G -- Ritchie, J M -- NS 08304/NS/NINDS NIH HHS/ -- NS 12327/NS/NINDS NIH HHS/ -- NS 15320/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 28;228(4707):1502-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409596" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/ultrastructure
;
Cell Membrane/ultrastructure
;
Freeze Fracturing
;
Ion Channels/*ultrastructure
;
Microscopy, Electron
;
Nerve Fibers, Myelinated/*ultrastructure
;
Neuroglia/ultrastructure
;
Potassium/metabolism
;
Rabbits
;
Ranvier's Nodes/ultrastructure
;
Regeneration
;
Sodium/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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