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  • Chemistry  (87,124)
  • General Chemistry  (14,762)
  • Organic Chemistry  (12,901)
  • GEOPHYSICS  (9,064)
  • 1980-1984  (36,838)
  • 1970-1974  (33,093)
  • 1955-1959  (13,373)
  • 1950-1954  (9,224)
  • 1945-1949  (3,660)
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  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 3
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 4
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 5
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 7
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 8
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 9
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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  • 10
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 11
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 12
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 13
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 14
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 15
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 16
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 18
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 19
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 20
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 21
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 22
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 23
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 24
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 28
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 29
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 30
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 31
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 32
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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  • 33
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 35
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    Total and spectral solar irradiance measured at ground surface (1982)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: This paper presents the results of a series of total and spectral solar irradiance measurements made at ground surface (Table Mountain Facility, Calif., altitude 2.18 km). The spectral irradiance data are presented for the 0.3-3.0-micron spectral region for air mass 1.5.
    Keywords: GEOPHYSICS
    Type: Applied Optics (ISSN 0003-6935); 21; 3, Fe
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    Organic geochemistry of Early Precambrian sediments (1972)
    In:  Other Sources
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    Publication Date: 2011-12-21
    Keywords: GEOPHYSICS
    Type: Life Sci. Publ., Vol. 2; 11 p
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  • 37
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    Preliminary examination of lunar samples (1970)
    In:  Other Sources
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    Publication Date: 2011-12-21
    Description: Geochemical and minerological analyses of Apollo 12 soil and rock samples
    Keywords: GEOPHYSICS
    Type: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 189-216
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    Preliminary geologic investigation of the Apollo 12 landing site. Part B - Photometric and polarimetric properties of the lunar regolith (1970)
    In:  CASI
    Details
    Publication Date: 2004-12-06
    Description: Photometric and polarimetric properties of Apollo 12 and Surveyor 3 landing sites
    Keywords: GEOPHYSICS
    Type: NASA. MANNED SPACECRAFT CENTER APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 157-161
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    Preliminary geologic investigation of the Apollo 12 landing site. Part C - Mechanical properties of the lunar regolith (1970)
    In:  CASI
    Details
    Publication Date: 2004-12-06
    Description: Soil mechanics of regolith around Apollo 12 landing site
    Keywords: GEOPHYSICS
    Type: NASA MANNED SPACECRAFT CENTER APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 161-182
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  • 40
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    Preliminary geologic investigation of the Apollo 12 landing site. Part A - Geology of the Apollo 12 landing site (1970)
    In:  CASI
    Details
    Publication Date: 2004-12-06
    Description: Apollo 12 landing site geology and topography
    Keywords: GEOPHYSICS
    Type: NASA. MANNED SPACECRAFT CENTER APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 113-156
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  • 41
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    Passive seismic experiment (1970)
    In:  CASI
    Details
    Publication Date: 2004-12-06
    Description: Apollo 12 passive seismometer design and signal interpretation
    Keywords: GEOPHYSICS
    Type: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 39-53
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  • 42
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    Lunar surface magnetometer experiment (1970)
    In:  CASI
    Details
    Publication Date: 2004-12-06
    Description: Apollo 12 magnetometer data and selenomagnetic field determinations
    Keywords: GEOPHYSICS
    Type: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 55-73
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  • 43
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    Preliminary results from Surveyor 3 analysis (1970)
    In:  CASI
    Details
    Publication Date: 2004-12-01
    Description: Engineering and scientific analysis of Surveyor 3 dust, TV camera, and structural components
    Keywords: GEOPHYSICS
    Type: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 217-223
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  • 44
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    Chemistry of the upper atmosphere and the role of transport processes (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The important chemical reaction affecting the neutral composition of the upper stratosphere, mesosphere, and lower thermosphere is discussed. The role of atmospheric transport processes is emphasized and the problem of taking these into account is elucidated.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Phys. of the Space Environment; p 147-155
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  • 45
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    Transient heating in the upper atmosphere (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The time-dependent response of the upper atmosphere to transient heat sources is considered. The basic problem is that of heating a compressible, heat-conducting fluid, which is described in the one-dimensional case by an analytic solution. Comparisons with satellite drag data of such first-order solutions are shown to be useful in determining energy requirements and in determining some constraints on the spatial distribution of the heating. Recent OGO-6 mass spectrometer and interferometric temperature measurements show that atmospheric disturbances during geomagnetic storms are much more prominent in the auroral zones. These results suggest that joule dissipation of auroral currents are important contributors to orbital perturbations of satellites.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Phys. of the Space Environment; p 3-23
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  • 46
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    Dissipation of electric fields in the ionosphere (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The heating and movement of the upper atmosphere at ionospheric levels in response to electric currents are discussed. Joule dissipation, generation of winds, and pressure gradients are significant factors in the energetics of the ionospheric electric currents flowing during magnetic storms and also of the Sq current system.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Phys. of the Space Environment; p 25-40
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  • 47
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    Nimbus observation of oceanic upwelling (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Observing the development of upwelling on the northeast coast of Africa by measuring ocean surface emission with infrared radiometers on Nimbus satellites is reported. Using the temperature of the ocean as telemetered by the satellite, the biological potential of an area is estimated, and consequently the highest potential for fisheries.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 14-17
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  • 48
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    Microwave emission of Arctic Sea ice (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The feasibility of carrying microwave radiometers on Nimbus E and F missions for sea ice surveys was studied in the arctic using aircraft. It was found that passive microwave signatures of Arctic Sea ice relate specifically to the structure and type of ice. It is concluded that a new tool for conducting ice surveys from aircraft and satellites with remote sensors was discovered.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 18-21
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  • 49
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    Electron impact ionization of H (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The results of theoretical calculations for the reactions between electrons and negative hydrogen atoms are discussed for an electron colliding with a negative hydrogen ion and neutralizing the hydrogen ion by stripping the loosely bound electron from it, and the two free electrons moving away. A semi-quantum description of the process is presented in which the target is described in terms of quantum mechanics, and the projectile electron is described in a classical fashion.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 58-62
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  • 50
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    Geological features in Wyoming from Nimbus 1 (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The identification of ground features in Nimbus photography by comparisons with geology, soils, and vegetation maps is discussed for the Wyoming-Colorado area. It is concluded that in a semiarid region, high topographic relief shows good coassociation with exposed geology and with vegetation and, to a lesser degree, with soils types. In lower, flatter basins, most tonal patterns are related to subtle variations in soil color and vegetation cover. It is thought that maps based on spectral parameters as the proper descriptor of surface features may be required.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 2-7
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    On the heterodyne method of detecting gravitational waves (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: A mathematical model on the heterodyne method of detecting gravitational waves is presented, using a dumbbell consisting of two masses situated in a plane and a plane-fronted gravitational wave traveling perpendicular to the plane. It is concluded that the detector sensitivity is not likely to be improved without employing very complicated and expensive super low temperature techniques.
    Keywords: GEOPHYSICS
    Type: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 45-46
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    Ground truth versus no ground truth (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The area of study was the southeastern Arizona test site and three areas within the site were studied in detail: Safford, Point of Pines, and Fort Apache-White River. These areas have terrain contrast ranging from flat arid regions to high alpine mountains. Data were obtained from the Apollo 9 photographic missions, high altitude aerial photography, and simulated ERTS-A data from high altitude aircraft. Various monoscopic and steroscopic devices were used to analyze the features, and film density variations were studied. No ground-based data were permitted. Thematic maps were prepared for geology, geomorphology, vegetation, hydrology, and soils. Interpreted boundaries were delineated, with no collaborative data used in the interpretation. Ground-based data were gathered during the overflight of high altitude aerial photography. A further study was made using the ground truth, and the data gathered on the ground were compared with original mapping. 80% to 85% of the interpretations in the areas checked were correct. It was proved that it is possible to monitor gross features of the vigor of crop lands and vegetative cover, to type soils and classify geologic features, and to determine hydrologic conditions.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 3 p
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    Preprocessing of multispectral data and simulation of ERTS data channels to make computer terrain maps of a Yellowstone National Park test site (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The possibility of improving the accuracy of terrain classification by preprocessing spectral data was investigated. Terrain maps were made using the following techniques: 1) preprocessing by scan angle function transformation, using the computer-selected best set of three channels; and 2) preprocessing by ratio transformation, using the specified ERTS data channels, simulated by fitting the spectral response of each of the 12 data channels to the ERTS channels by a set of weighting coefficients. By using a simple technique during printout, the maps were produced in color. The normalized scan angle function transformation resulted in the most accurate classification. The best ratio transformation for the Yellowstone Park data was the ratio of each channel to the sum of all channels. A supervised training program involving maximum likelihood decision for selecting the best spectrometer channels and similar techniques for digitizing the data of the analog magnetic tapes were used. Cloud shadows were recognized in addition to eight classes of terrain. Preprocessing of data resulted in more accurate maps, required fewer training areas (hence less preparation and computer time), and enabled much of the area formerly classified as shadow to be reclassified according to actual terrain type.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1.; 25 p
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    Regional land use studies (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Remote sensing technology and data from instrumented satellites and high altitude aircraft are proposed for mapping land use on a current national basis, for monitoring changes and trends, and for creating statistical models which can be manipulated to demonstrate the probable effects of proposed land use and of environmental changes over large areas. Both Apollo spacecraft and aircraft photography were used; the spacecraft pictures delineated the cropland and urban boundaries more clearly. A computer model is also proposed for statistical analysis and for printing out updated maps automatically; this model will include a data bank which can be updated rapidly with changes detected by the computer.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 9 p
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    A cursory examination of the sensitivity of the tropospheric range and Doppler effects to the shape of the refractivity profile (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-27
    Description: Ray tracing techniques for examination of refractivity profile sensitivity in tropospheric range and Doppler effects on profile shape
    Keywords: GEOPHYSICS
    Type: THE DEEP SPACE NETWORK, VOL. 1 15 FEB. 1971; P 22-30
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    Bearing strength of the lunar soil (1972)
    In:  CASI
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    Publication Date: 2005-11-30
    Description: A discussion is presented on the bearing strength and bearing load-penetration relations in lunar soil. These were measured in air as a function of bulk density. It was found that the relation between bulk density and the logarithm of the bearing capacity is about linear. Shapes of the load vs penetration curves were observed to be similar to those obtained with particulate material of terrestrial origin.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Analysis of Surveyor 3 Mater. and Phot. Returned by Apollo 12; p 227-232
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    Comparison of probe and radar ionosphere temperatures (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The discrepancy in temperature measurements of ionospheric electrons by Langmuir electrostatic probes, and radar backscatter are discussed. The discrepancy occurs at altitudes from 350 to 800km, and the probe temperatures are consistantly higher than the radar temperatures. It is concluded that the non-Maxwellian energy distribution provides an explanation for the altitude and the lower radar temperatures.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 43-45
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    Microwave measurements of sea state (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Passive microwave measurements were studied for determining sea state. It was found that the brightness temperature increases due to the foam produced by winds, and that the surface wind can be determined by the brightness temperature.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 22-27
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    An Eotvos experiment in earth orbit (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The gravitational interactions of mass energy stored in the weak interaction are being investigated. The magnitude of possible Eotvos anomalies, such as weak interaction, gravitational self-energy, spin-orbit interactions, and electromagnetic radiation reaction, are considered. A sensitive experiment was designed to determine whether weak interaction energy violates the equivalence principle. Factors to be considered in spacecraft design for the experiment are presented.
    Keywords: GEOPHYSICS
    Type: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 228-235
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    Observations of earth eigen vibrations possibly excited by low frequency gravity waves (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: A cryogenic gravity meter made of two parts, a magnetic suspension unit and a detection module, was used to monitor earth eigen vibrations. The magnetic field and field gradient are generated by energizing a set of superconducting coils made of niobium-zirconium alloy wire. The detection module is a double Josephson junction magnetometer. The output is printed on a chart recorder and later digitized using a computer; a Fourier transformation is performed on the accumulated data. The measurements of eigen vibrations are summarized in tabular and graphical representations.
    Keywords: GEOPHYSICS
    Type: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 47-53
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    Experiment M405: Tri-axis flux gate magnetometer (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: A tri-axis flux-gate magnetometer was used on four Gemini spacecraft for determination of the magnitude and direction of the local geomagnetic field with respect to the spacecraft. Conclusions derived from the data are not only important to the proton-electron spectrometer experiment, but also are of significance to any directional charged particle experiments that may be conducted. Even though the Gemini spacecraft was not clean magnetically, the data could be reduced to a form that supplied directional information on the magnetic field in relation to the spacecraft. Stray fields were the result of spacecraft structure, not the result of current flows that were produced within the spacecraft electrical systems. Efforts were made to reduce spacecraft stray fields and to facilitate the acquisition of more accurate data.
    Keywords: GEOPHYSICS
    Type: The Gemini Program: Phys. Sci. Expt. Sum.; p 153-168
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    ESRO study program for a space experiment on gravitation theories (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: ESRO is considering a space experiment which is the definition phase. A more complete utilization of space techniques, leading to highly accurate acceleration measurements in a heliocentric spacecraft, together with an improved laser signal propagation method (using a space-borne atomic clock), could substantially increase the validity of the gravitational time delay test during solar conjunction. Preliminary investigations of the primary required techniques were carried out. These studies included an orbit analysis, investigation of drag-free techniques, and studies of the time measuring instrument. These studies were used to define the framework of a space experiment on gravitation theories. A preliminary feasibility study of the mission is being undertaken.
    Keywords: GEOPHYSICS
    Type: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 236-241
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    Testing general relativity: Progress, problems, and prospects (1971)
    In:  CASI
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    Publication Date: 2005-11-30
    Description: The results from ground-based experimental testing are presented. Prospects for improving these experiments are discussed. Radar echo time delays, perihelion advance and solar oblateness, time variation of the gravitational constant, and radio wave deflection are considered. Ground-based and spacecraft techniques are compared on an accuracy vs. cost basis.
    Keywords: GEOPHYSICS
    Type: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 136-147
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    The energy balance of wind waves and the remote sensing problem (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Measurements of wave growth indicate an energy balance of the wave spectrum governed primarily by input from the atmosphere, nonlinear transfer to shorter and longer waves, and advection. The pronounced spectral peak and sharp low frequency cut-off characteristic of fetch-limited spectra are explained as a self-stabilizing feature of the nonlinear wave-wave interactions. The momentum transferred from the atmosphere to the wind waves accounts for a large part of the wind drag. These findings are relevant for remote microwave sensing of the sea surface by backscatter and passive radiometry methods.
    Keywords: GEOPHYSICS
    Type: NOAA Sea Surface Topography from Space, Vol. 2; 55 p
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    Comments on ocean circulation with regard to satellite altimetry (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Basic features of sea surface topography are reviewed, to show those oceanographic results which may be of value to a geodetic satellite program: (1) the shape and magnitude of the large scale features of the mean sea surface, relative to a level surface; (2) the position and magnitude of the slopes across the western boundary currents, from a variety of data; (3) an estimate of the position of the geoid, tied into the U.S. leveling network; and (4) a documented change of 60 to 70 cm in mean sea level, with respect to the geoid, between the U.S. east and west coasts.
    Keywords: GEOPHYSICS
    Type: NOAA Sea Surface Topography from Space, Vol. 2; 17 p
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    The stable auroral red arc of October 31 - November 1, 1968 and its interaction with the neutral atmosphere (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Satellite observations of electron temperature and the topside electron density structure are used to calculate the red arc according to the thermal conduction model. In this model, energy from the magnetosphere flows in the electron gas along geomagnetic field lines into the ionosphere. This energy heats the ambient F-region electrons sufficiently to excite the oxygen atoms to the O I(1D) level by collisional impact giving rise to the 6300 A emission characteristic of the arc. For the 31 October/1 November 1968 red arc, the calculated emission rate, geographical position, and horizontal extent of the red arc are in agreement with the photometric data obtained by airglow observatories. Almost all of the energy conducted into the red arc is ultimately transferred to the neutral gas through elastic and inelastic collisions. This energy drives a large thermal cell and the circulation extends the influence of the arc thousands of kilometers beyond the region of direct heat input. The calculated neutral gas temperature response to electron heating within the arc is small.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Phys. of the Space Environment; p 45-69
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    The composition of the upper atmosphere (1972)
    In:  CASI
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    Publication Date: 2005-11-30
    Description: Miniature mass spectrometers were developed and were carried on sounding rockets to determine the composition of the upper atmosphere. Techniques have been developed that accurately correct for the velocity and spin of the moving vehicle. Above 120 km N2, O2, and Ar appear to be in diffusive equilibrium. Most He concentration measurements show a more rapid decline with altitude than predicted by diffusive equilibrium. Because of the highly reactive nature of atomic oxygen, measurements of this species by mass spectrometry are low by an unknown factor.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Phys. of the Space Environment; p 129-145
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    Hydrology of the Niger River from Nimbus HRIR (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The seasonal changes in aspect of the Niger River in the Republic of Mali, West Africa, as seen in daytime imagery obtained by the high-resolution infrared radiometer on Nimbus 3 are described. The identification of different plants by their reflectance is shown to provide an ecological map that changes with time. It is concluded that Nimbus imagery provides an integrated view of the entire watershed on a daily basis.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 8-13
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    Air-sea interaction in the Pacific Ocean (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Daily Tiros and ESSA satellite television nephanalysis over the Pacific Ocean were collected, and monthly cloud charts drawn to study the interaction of tropical oceans with the atmosphere. The data were correlated with climatological data for rainfall and surface temperatures.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 28-31
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  • 70
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    Reginal Geology of Hadley Rille, part F (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Local geology of Hadley Rille near the landing site of Apollo 15 is described. Orbital photography from the Hasselblad, metric, and panoramic cameras is used to study regional relationships of the rille. The shape of the rille due to various natural causes is examined, along with stratigraphic measurements of mare materials.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center Apollo 15 Prelim. Sci. Rept.; 5 p
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    Surface disturbances at the Apollo 15 landing site, part E (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: High resolution panoramic photographs taken from 110 km orbits of the command service module show the lunar module structure on the moon as evidenced by reflected light and by the shadow. Before and after photographs of the landing site are presented; the increased brightness or halo is attributed to mare surface materials.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center Apollo 15 Prelim. Sci. Rept.; 3 p
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  • 72
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    Linear geologic structure and magic rock discrimination as determined from infrared data (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Color infrared photographs of the Beartooth Mountains, Montana show the distribution of mafic dikes and amphibolite bodies. Lineaments that cross grassy plateaus can be identified as dikes by the marked constrast between the dark rocks and the red vegetation. Some amphibolite bodies in granitic terrain can also be detected by infrared photography and their contacts can be accurately drawn due to enchanced contrast of the two types of rock in the near infrared. Reflectance measurements made in the field for amphibolite and granite show that the granite is 25% to 50% more reflective in the near infrared than in the visible region. Further enhancement is due to less atmospheric scattering than in the visible region. Thermal infrared images of the Mill Creek, Oklahoma test site provided information on geologic faults and fracture systems not obtainable from photographs. Subtle stripes that cross outcrop and intervening soil areas and which probably record water distribution are also shown on infrared photographs.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 12 p
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    Experimental applications of multispectral data to natural resource inventory and survey (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The feasibility of using multispectral, color, color infrared, thermal infrared imagery and related ground data to recognize, identify, determine and monitor the status of mineral ore and metals stockpiles is studied. An attempt was made to identify valid, unique spectral signatures of such materials for possible use under a wide variety of environmental circumstances. Research emphasis was upon the analysis of the multiband imagery from the various film-filter combinations, using density analysis techniques.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 33 p
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  • 74
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    Introductory comments on the USGS geographic applications program (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The third phase of remote sensing technologies and potentials applied to the operations of the U.S. Geological Survey is introduced. Remote sensing data with multidisciplinary spatial data from traditional sources is combined with geographic theory and techniques of environmental modeling. These combined imputs are subject to four sequential activities that involve: (1) thermatic mapping of land use and environmental factors; (2) the dynamics of change detection; (3) environmental surveillance to identify sudden changes and general trends; and (4) preparation of statistical model and analytical reports. Geography program functions, products, clients, and goals are presented in graphical form, along with aircraft photo missions, geography test sites, and FY-70.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 5 p
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  • 75
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    Tests of the equivalence principle and gravitation theory using solar system bodies (1971)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The M sub g/M sub i ratio (ratio of body acceleration to gravitation field) of celestial bodies was measured. Deep probes of the post-Newtonian structure of gravitational theories are indicated. Kepler's third law is considered for the Sun-Jupiter system.
    Keywords: GEOPHYSICS
    Type: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 32-37
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    A review of application studies on Indian lands using NASA aerospace imagery (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Three remote sensing projects are being conducted on three different Indian reservations in eastern Arizona. On the Fort Apache Reservation, a multiband thermal and false color sensing of an Englemann spruce beetle infestation is being investigated on Mount Baldy, adjacent to a U.S. Forest Service proposed wilderness area. On the San Carlos Reservation, there is a joint USGS, EROS, and San Carlos tribe project to examine intensively a circular topographic feature noted on the Apollo 9 imagery. On the Papago Reservation, an EROS-funded contract will provide the Papago tribe with a report showing potential mineral areas, by comparing and correlating space imagery with high resolution imagery and aeromagnetic data.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 6 p
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  • 77
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    Geologic interpretation of Apollo 6 stereophotography from Baja California to west Texas (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Excellent space photography of parts of the southwestern United States and northwestern Mexico was obtained during the unmanned Apollo 6 spaceflight. Two features of this photography made it useful for geologic interpretations: its vertical stereocoverage and its exposure under a relatively low angle of solar illumination through an unusually cloud-free and clear atmosphere. The structural patterns, which were topographically enhanced by the longer shadows, were annotated on the photographs, in order to analyze their trends with respect to the continental tectonic framework, and to attempt to correlate the pattern with known copper or other base metal deposits. The annotated fracture patterns showed the regional trends and their distribution. The area studied was a 100- to 105-mile swath of terrain covering a total land area of approximately 60,000 square statute miles. The coverage began from a point centered on Punta Colnett on the Pacific coast of Baja California and extended to the Sacramento Mountains of New Mexico and west Texas.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 25 p
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  • 78
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    A study of passive microwave techniques applied to geologic problems (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Passive microwave techniques were applied to geologic problems, in order to establish the microwave properties of representative rocks and minerals, and to examine the feasibility of using microwave radiometry for geologic mapping problems. A review of microwave pertaining to geology was conducted, coupled with laboratory and field investigations of the microwave emission characteristics of various geologic features. The laboratory studies consisted of dielectric constant measurements of rocks and minerals. A majority of field investigations conducted in the western United States, involved the microwave emission charateristics of rock types, and a portion of the study was concerned with microwave properties of mineralized areas. Experiments were also conducted in the vicinity of a coal seam fire in Colorado and across the San Andreas Fault Zone near the Salton Sea, in Southern California.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 12 p
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  • 79
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    Geography program, design, structure and operational strategy (1970)
    In:  CASI
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    Publication Date: 2005-11-30
    Description: The geography program is designed to move systematically toward a capability to increase remote sensing data into operational systems for monitoring land use and related environmental change. The problems of environmental imbalance arising from rapid urbanization and other dramatic changes in land use are considered. These overall problems translate into working level problems of establishing the validity of various sensor-data combinations that will best obtain the regional land use and environmental information. The goal, to better understand, predict, and assist policy makers to regulate urban and regional land use changes resulting from population growth and technological advancement, is put forth.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spececraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 9 p
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    Environmental application of remote sensing methods to coastal zone land use and marine resources management (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The interrelationships of biophysical environmental systems are investigated. Social decision-making affecting the environments of a coastal megapolis are examined. Remote sensing from high altitude aircraft and satellites afforded a powerful and indepensible tool for inventory and planning for urban development. Repetitive low to medium altitude photography is also used for studying environmental dynamics, and to document the cultural impact of man on his environment.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 9 p
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  • 81
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    Tides and tsunamis (1972)
    In:  CASI
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    Publication Date: 2005-11-30
    Description: Although tides and tsunamis are both shallow water waves, it does not follow that they are equally amenable to an observational program using an orbiting altimeter on a satellite. A numerical feasibility investigation using a hypothetical satellite orbit, real tide observations, and sequentially increased levels of white noise has been conducted to study the degradation of the tidal harmonic constants caused by adding noise to the tide data. Tsunami waves, possibly a foot high and one hundred miles long, must be measured in individual orbits, thus requiring high relative resolution.
    Keywords: GEOPHYSICS
    Type: Sea Surface Topography from Space, Vol. 2; 30 p
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  • 82
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    Cracking of the lunar soil (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Rather than a pattern of cracks in an apparently flat surface, the Apollo 12 photographs suggest an irregular surface that consists of clods or fragments. The impression of flat tiles and crusting, obtained by monoscopic viewing, is an illusion. Instead, the lunar soil deforms and cracks in the same manner as homogeneous isotropic terrestrial soils of moderate bulk density, having a small amount of cohesion.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Analysis of Surveyor 3 Mater. and Phot. Returned by Apollo 12; p 233-235
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  • 83
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    Preliminary geologic map of the region around the candidate Proclus Apollo landing site, part J (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The Proclus Crater region was mapped to test the value, for photogeologic mapping purposes, of Apollo 15 metric photographs and to estimate the scientific value of the area as a potential landing site. Adjacent frames of the metric photography were overlapped with the base frame to provide stereographic images. Because of the high quality of the photographs, it was found that the geologic units could be more definitely interpreted and dated than those of earlier maps. The photographs tend to confirm the earlier interpretation of the rugged area as composed of bedrock uplifted when the Crisium basin formed. They also suggest that an earlier predominantly volcanic interpretation of the terra in this area might be replaced by an interpretation in which mass wasting and fracturing play the major roles in producing different terrain types. It was concluded that because of apparent lithologic homogeneity, the terra of the Proclus region is an undesirable objective for an extensive manned lunar landing mission.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center Apollo 15 Prelim. Sci. Rept.; 4 p
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  • 84
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    Magnetospheric boundaries (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The location of the outer boundary of the geomagnetic field, or magnetopause, and the location of the earth's bow shock have been compiled based on data from the first six IMP satellites.
    Keywords: GEOPHYSICS
    Type: Significant Accomplishments in Sci., 1970; p 81-85
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  • 85
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    Relationship between vegetation reflectance spectra and soil geochemistry: New data from Catheart Mountain, Maine (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Spectral reflectance curves for red spruce and balsam fir in the 350- to 1100-nanometer region showed differences between specimens growing over and away from a concealed copper deposit at Catheart Mountain, Maine. A sample group of 15 anomalous spruce, 9 background spruce, 10 anomalous fir, and 10 background fir was studied. Measurements of copper and molybdenum contents in the supporting soil were used to categorize the trees as anomalous or background. Analyses using parametric and nonparametric statistical tests were performed to establish whether significant differences existed between the anomalous and background groups. At the 95% confidence level, significant differences were found to exist for both species, generally in the chlorophyll band centered at about 550 nanometers and in the region from 700 to 900 nanometers.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 9 p
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  • 86
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    Remote sensing in marine geology: Arctic to Caribbean (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The applications of remote sensing to coastal dynamics of both nearshore and offshore waters are discussed. Results of aerial photographic analysis of four areas are presented. The study areas include the Arctic (Beaufort Sea), the Pacific Northwest, San Francisco Bay, and St. John, Virgin Islands (Project Tektite).
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 17 p
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    Multispectral analysis of limestone, dolomite, and granite, Mill Creek, Oklahoma (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Spectral reflectance and thermal emission data were collected at the Mill Creek, Oklahoma test site during NASA missions 132 and 133 in June 1970. The data were collected by three aircraft flown several times during the diurnal cycle at altitudes of 150 to 17,000 m above mean terrain. Reflectance of the main rock types (limestone, dolomite, and granite) was determined from the data collected using a 12-channel multispectral scanner during mission 133 and from thermal infrared images recorded during mission 132 on an RS-7 scanner from 17,000 m above terrain. A preliminary rock recognition map was generated automatically using data collected from 900 m above terrain. The discrimination provided by the map is reasonably accurate. Misidentification occurred in areas of unusually high dolomite reflectivity. High altitude thermal infrared (10 to 12 micrometers) images show regional folds and faults distinguished by the presence of thermally contrasting materials. Linear and curvilinear structural features two to three times smaller than the nominal 17 m resolution could be detected.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 114 p
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    Special projects of the geographic applications program (1970)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Alternative uses were investigated for the Mississippi Test Facility since the phaseout of Saturn 5 engine testing. Using the facility for collecting remotely sensed data is suggested for regional studies. The capabilities of various remote sensing devices to detect, identify, monitor, or determine effects of environmental pollution are summarized. Which pollutants could be monitored from spacecraft, high and low altitude aircraft, and ground based platforms are determined. Examples of special processing and enhancement and analysis techniques used in connection with remote sensing data are provided.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 7 p
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    Climatology of urban regional systems (1970)
    In:  CASI
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    Publication Date: 2005-11-30
    Description: The combining of remote sensing technologies to urban-regional energy climatology is studied. It was found to be three dimensional with a mosaic urban surface, each smaller surface with its own radiant and thermal properties. Urban patterns of radiant exchange were found to be constantly changing during diurnal and annual cycles. Results were derived from Barbados data using remote methods for monitoring and mapping radiation. Isoline maps of terrestrial radiation patterns were made generalizing the minute patterns of the scan image.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 11 p
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  • 90
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    Geologic terrain mapping from earth-satellite and ultra-high aerial photographs (1970)
    In:  CASI
    Details
    Publication Date: 2005-01-18
    Description: A proposal is made for mapping from aerial photographs from the EROS program. Three kinds of maps (geomorphic or landform, soil, and surficial deposit) are being prepared at 1:250,000 scale for an 8000-square-mile area between Tucson and Ajo, Arizona. Nine cameras used on NASA mission 101 provided color, color infrared, and multispectral air photos from about 60,000 feet above the terrain and with photo scales ranging from 1:60,000 to 1:240,000. This area was selected because it provides a good sample of desert terrain and is suited for improving and testing the photointerpretive techniques for mapping geologic terrain features with small-scale photos.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 5 p
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    Classification of volcanoes of the Kane Patera Quadrangle of Io: Proportions of lava flows and pyroclastic flows (1984)
    In:  CASI
    Details
    Publication Date: 2009-11-16
    Description: Voyager 1 images show 14 volcanic centers wholly or partly within the Kane Patera quadrangle of Io, which are divided into four major classes: (1) shield with parallel flows; (2) shield with early radial fan shapd flows; (3) shield with radial fan shaped flows, surfaces of flows textured with longitudinal ridges; and (4) depression surrounded by plateau-forming scarp-bounded, untextured deposits. The interpretation attempted here hinges largely on the ability to distinguish lava flows from pyroclastic flows by remote sensing.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Rept. of Planetary Geol. Program, 1983; p 127-129
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  • 92
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    Infrared scanning radiometer (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The Apollo 17 infrared scanning radiometer (ISR) experiment for mapping lunar surface thermal emission is reported. The instrument, lunar surface coverage, and the data obtained are discussed.
    Keywords: GEOPHYSICS
    Type: Apollo 17 Prelim. Sci. Rept.; 6 p
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  • 93
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    Lunar atmospheric composition experiment (1973)
    In:  CASI
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    Publication Date: 2006-01-11
    Description: On the Apollo 17 mission, a miniature mass spectrometer, called the lunar atmospheric composition experiment (LACE), was carried to the moon as part of the Apollo lunar surface experiments package (ALSEP) to study the composition of and variation in the lunar atmosphere. The instrument was successfully deployed in the Taurus-Littrow valley with its entrance aperture oriented upward to intercept and measure the downward flux of gases at the lunar surface. Initial activation of the LACE instrument occurred on December 27, 1972, approximately 50 hr after sunset, and operation continued throughout the first lunar night. Sunrise brought a high background gas level and necessitated discontinuing operation during lunar daytime except for a brief check near noon. Near sunset, operation was resumed and continued throughout the night. This sequence was repeated for the second and third lunations.
    Keywords: GEOPHYSICS
    Type: NASA. Johnson Space Center Apollo 17 Prelim. Sci. Rept.; 9 p
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    A proposal for observations of upper and middle tropospheric clouds (1982)
    In:  CASI
    Details
    Publication Date: 2008-07-17
    Description: A proposal for a multi-institutional investigation of the processes involved in the growth and maintenance of high level extended clouds is presented. Mapping of variability of the cloud and of its radiative characteristics in terms of the meteorological environment of the cloud; performance of case studies involving observation of the cloud microphysics and radiation characteristics; and investigation of the processes responsible for the generation, maintenance, and dissipation of the cloud system are recommended. Both modeling and monitoring activities are considered. The specific research projects which the author proposes to carry out are described. Suggestions for the administrative organization of the total effort are presented.
    Keywords: GEOPHYSICS
    Type: Initial Studies of Middle and Upper Tropospheric Stratiform Clouds; 56 p
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    A middle and upper tropospheric cloud model (1982)
    In:  CASI
    Details
    Publication Date: 2008-07-17
    Description: The interplay of the various physical processes involved in the formation, maintenance, and decay of middle and upper tropospheric stratiform clouds is discussed. Ice phase fair weather cloud forms are considered. Simulations of cirriform clouds which attempt to incorporate the physical processes in an interactive manner were performed. A two dimensional time dependent Eulerian numerical model, which incorporates all of the important physical processes in a simplified way, is employed to investigate the role of these processes in the evolution of a cloud in an isolated atmospheric layer. Physical parameters considered are the eddy viscosity and the thermal, water vapor, and ice water eddy diffusivities.
    Keywords: GEOPHYSICS
    Type: Initial Studies of Middle and Upper Tropospheric Stratiform Clouds; 189 p
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  • 96
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    Interpretation of planetary stress systems: Determination of tectonic over-printing in Northwest Wyoming (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Structural and tectonic interpretations of planetary surfaces rely strongly on visual determination of regional structural grain. This grain can be very complex and confusing, and sorting out of discrete trends in time and space is of utmost importance. This study is a test of these techniques applied to a well known area having several discrete structural grains. In the Bighorn Basin region of Wyoming, a largely overlooked N10E structural grain has been verified with detailed structural analysis and indicates a significant change in stress orientation at the end of the Laramide orogeny.
    Keywords: GEOPHYSICS
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 307-309
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  • 97
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    Volcanism in the Valles Marineris (1984)
    In:  CASI
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    Publication Date: 2006-04-06
    Description: Tectoism in the Valles Marineris appears to have been accompanied by volcanism. The proposed volcanic features, though probably contemporaneous with the gigantic ones in the Tharsis area, are composed of small, mafic and, possibly, somewhat larger felsic flows. The size of these features is similar to that of volcanic flows on the Earth.
    Keywords: GEOPHYSICS
    Type: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 135-137
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  • 98
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    Experiments on water/melt explosions, nature of products, and models of dispersal (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Experiments were carried out in a steel pressure device using controlled amounts of water and thermite melt to examine the mechanical energy released on explosive mixing following the initial contact of the two materials. An experimental design was used to allow the direct calculation of the mechanical energy by the dynamic lift of the device as recorded both optically and physically. A large number of experiments were run to accurately determine the optimum mixture of water and melt for the conversion of thermal to mechanical energy. The maximum efficiency observed was about 12% at a water/thermite mass ratio of 0.50. These experiments are the basis for the development of models of hydroexplosions and melt fragmentation. Particles collected from the experimental products are similar in size and shape to pyroclasts produced by much larger hydrovolcanic explosions. Melt rupture at optimum ratios produces very fine particles whereas rupture at high or low water/melt ratios produces large melt fragments. Grain surface textures in the experimental products are also related to the water/melt ratio and the mechanism of explosive mixing. It is thus possible to have qualitative information about the nature of the explosion from the sizes and shapes of the fragments produced.
    Keywords: GEOPHYSICS
    Type: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 144-146
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    Atmospheric electricity (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-02
    Description: Atmospheric electricity must be considered in the design, transportation, and operation of aerospace vehicles. The effect of the atmosphere as an insulator and conductor of high voltage electricity, at various atmospheric pressures, must also be considered. The vehicle can be protected as follows: (1) By insuring that all metallic sections are connected by electrical bonding so that the current flow from a lightning stroke is conducted over the skin without any gaps where sparking would occur or current would be carried inside; (2) by protecting buildings and other structures on the ground with a system of lightning rods and wires over the outside to carry the lightning stroke into the ground; (3) by providing a zone of protection for launch complexes; (4) by providing protection devices in critical circuits; (5) by using systems which have no single failure mode; and (6) by appropriate shielding of units sensitive to electromagnetic radiation.
    Keywords: GEOPHYSICS
    Type: Terrest. Environ. (Climatic) Criteria Guidelines for Use in Aerospace Vehicle Develop., 1973 Rev.; 28 p
    Format: text
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    Ionospheric profile inversion using oblique-incidence ionograms (1972)
    In:  CASI
    Details
    Publication Date: 2006-03-12
    Description: Some of the elementary methods used in deriving true-height profiles from oblique-incidence ionograms are reviewed. The two principal methods presented are oblique-to-vertical transformation and direct inversion of the oblique-incidence ionogram. Limitations in oblique-incidence inversion due to magnetic-field effects, horizontal gradients, and absolute time delay are discussed.
    Keywords: GEOPHYSICS
    Type: NASA. Ames Res. Center Math. of Profile Inversion; 12 p
    Format: text
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