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  • Chemistry  (91.005)
  • Polymer and Materials Science  (32.112)
  • GEOPHYSICS  (9.365)
  • Analytical Chemistry and Spectroscopy  (6.446)
  • 1980-1984  (39.495)
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  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-09-10
    Beschreibung: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-07-20
    Beschreibung: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-20
    Beschreibung: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-10-19
    Beschreibung: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-31
    Beschreibung: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-10-19
    Beschreibung: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-31
    Beschreibung: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-05-11
    Beschreibung: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-16
    Beschreibung: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-16
    Beschreibung: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-16
    Beschreibung: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-15
    Beschreibung: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-02
    Beschreibung: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-09
    Beschreibung: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-08
    Beschreibung: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-01-04
    Beschreibung: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-16
    Beschreibung: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-15
    Beschreibung: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 23
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 24
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-07-09
    Beschreibung: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 26
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-30
    Beschreibung: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-03-13
    Beschreibung: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-12-10
    Beschreibung: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 29
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-12-03
    Beschreibung: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 30
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 31
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 32
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 33
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-10-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-05-25
    Beschreibung: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Evaluation of thermal radiation at high temperatures (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Emittance measuring apparatus for temperatures up to 4000-deg f
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 36
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    A very rapid 3000 deg f technique for measuring emittance of opaque solid materials (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Total normal emittance measurement technique for opaque solid materials over 1000- to 3000-deg f range
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 37
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    Pitfalls in thermal emission studies (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Pitfalls in thermal emission studies - terminology, experimental procedure, and physical standards
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 38
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    Periodic heat flow in a hollow cylinder rotating in a furnace with a viewing port (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Rotating-specimen furnace for use in determining spectral & total emittance of materials from measurement of radiant flux from specimen surface
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 39
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    The total hemispherical emittance of platinum, columbium-1 percent zirconium, and polished and oxidized inor-8 in the range 100 deg to 1200 deg c (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Temperature dependence of hemispherical emittance of metal and alloy strips in 100- to 1200-deg c range using blackbody vacuum chamber
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 40
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    Measurement of spectral normal emittance of materials under simulated spacecraft powerplant operating conditions (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Spectral normal emittance of materials under simulated space environment
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 41
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    Heated cavity reflectometer modifications (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Heated cavity reflectometer for thermal reflectance measurements of opaque surface
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 42
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    Inspection tool for measurement of the radiation properties of satellite temperature control surfaces (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Apparatus for measuring emittance and absorptivity of satellite temperature control surfaces
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 43
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    An apparatus for measuring total hemispherical emittance between ambient and liquid nitrogen temperatures (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Apparatus for measuring hemispherical emittance of solids in ambient & liquid nitrogen temperature range, with copper & aluminum foil data
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 44
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    Thermocouple and radiation thermometry above 900 deg k (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Thermocouple and radiation thermometry above 900 deg k
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 45
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    Measurement of total hemispherical emittance of structural materials and coatings under simulated spacecraft conditions (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Hemispherical emittance of structural materials & coatings under simulated spacecraft conditions over wide temperature range
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 46
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    The measurement of total normal emittance of three nuclear reactor materials (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Measurement of total normal emittance of nuclear reactor materials - carbon steel, boron steel, & borated graphite
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 47
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    Radiative property measurements of thermal control coatings for spacecraft (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Solar absorptance, emittance, & transmittance of thermal control coating for spacecraft
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 48
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    Spectral emittance measurements from 40 deg c to 200 deg c (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Spectral emittance of opaque and transparent materials from 40- to 200-deg c
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 49
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    Hemispheric spectral reflectance of solids (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Hemispheric spectral reflectance of opaque solids
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 50
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    Calorimetric determination of infrared emittance and the absorptance/emission ratio (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Calorimetric device for determination of solar absorption & infrared emittance ratio of materials at room temperature
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
    Format: text
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  • 51
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    Thermal radiation properties of solids at low temperatures (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: Thermal radiation properties of solids at cryogenic temperatures
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 52
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    Temperature measurements below 1000 deg k 〈an abstract〈 (1963)
    In:  CASI
    Details
    Publikationsdatum: 2009-12-28
    Beschreibung: International practical temperature scale for temperature measurements below 1000-deg k using platinum resistance thermometers
    Schlagwort(e): GEOPHYSICS
    Materialart: Measurement of Thermal Radiation Properties of Solids; NASA-SP-31
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  • 53
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    Total and spectral solar irradiance measured at ground surface (1982)
    In:  Other Sources
    Details
    Publikationsdatum: 2011-08-24
    Beschreibung: This paper presents the results of a series of total and spectral solar irradiance measurements made at ground surface (Table Mountain Facility, Calif., altitude 2.18 km). The spectral irradiance data are presented for the 0.3-3.0-micron spectral region for air mass 1.5.
    Schlagwort(e): GEOPHYSICS
    Materialart: Applied Optics (ISSN 0003-6935); 21; 3, Fe
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  • 54
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    Organic geochemistry of Early Precambrian sediments (1972)
    In:  Other Sources
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    Publikationsdatum: 2011-12-21
    Schlagwort(e): GEOPHYSICS
    Materialart: Life Sci. Publ., Vol. 2; 11 p
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  • 55
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    Preliminary examination of lunar samples (1970)
    In:  Other Sources
    Details
    Publikationsdatum: 2011-12-21
    Beschreibung: Geochemical and minerological analyses of Apollo 12 soil and rock samples
    Schlagwort(e): GEOPHYSICS
    Materialart: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 189-216
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  • 56
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    Preliminary geologic investigation of the Apollo 12 landing site. Part B - Photometric and polarimetric properties of the lunar regolith (1970)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-06
    Beschreibung: Photometric and polarimetric properties of Apollo 12 and Surveyor 3 landing sites
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. MANNED SPACECRAFT CENTER APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 157-161
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  • 57
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    Preliminary geologic investigation of the Apollo 12 landing site. Part C - Mechanical properties of the lunar regolith (1970)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-06
    Beschreibung: Soil mechanics of regolith around Apollo 12 landing site
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA MANNED SPACECRAFT CENTER APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 161-182
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  • 58
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    Preliminary geologic investigation of the Apollo 12 landing site. Part A - Geology of the Apollo 12 landing site (1970)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-06
    Beschreibung: Apollo 12 landing site geology and topography
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. MANNED SPACECRAFT CENTER APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 113-156
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  • 59
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    Passive seismic experiment (1970)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-06
    Beschreibung: Apollo 12 passive seismometer design and signal interpretation
    Schlagwort(e): GEOPHYSICS
    Materialart: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 39-53
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  • 60
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    Lunar surface magnetometer experiment (1970)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-06
    Beschreibung: Apollo 12 magnetometer data and selenomagnetic field determinations
    Schlagwort(e): GEOPHYSICS
    Materialart: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 55-73
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  • 61
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    Preliminary results from Surveyor 3 analysis (1970)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-01
    Beschreibung: Engineering and scientific analysis of Surveyor 3 dust, TV camera, and structural components
    Schlagwort(e): GEOPHYSICS
    Materialart: APOLLO 12- PRELIM. SCI. REPT. 1 JUN. 1970; P 217-223
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  • 62
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    Chemistry of the upper atmosphere and the role of transport processes (1972)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-30
    Beschreibung: The important chemical reaction affecting the neutral composition of the upper stratosphere, mesosphere, and lower thermosphere is discussed. The role of atmospheric transport processes is emphasized and the problem of taking these into account is elucidated.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA, Washington Phys. of the Space Environment; p 147-155
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  • 63
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    Transient heating in the upper atmosphere (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The time-dependent response of the upper atmosphere to transient heat sources is considered. The basic problem is that of heating a compressible, heat-conducting fluid, which is described in the one-dimensional case by an analytic solution. Comparisons with satellite drag data of such first-order solutions are shown to be useful in determining energy requirements and in determining some constraints on the spatial distribution of the heating. Recent OGO-6 mass spectrometer and interferometric temperature measurements show that atmospheric disturbances during geomagnetic storms are much more prominent in the auroral zones. These results suggest that joule dissipation of auroral currents are important contributors to orbital perturbations of satellites.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA, Washington Phys. of the Space Environment; p 3-23
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  • 64
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    Dissipation of electric fields in the ionosphere (1972)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-30
    Beschreibung: The heating and movement of the upper atmosphere at ionospheric levels in response to electric currents are discussed. Joule dissipation, generation of winds, and pressure gradients are significant factors in the energetics of the ionospheric electric currents flowing during magnetic storms and also of the Sq current system.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA, Washington Phys. of the Space Environment; p 25-40
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  • 65
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    Nimbus observation of oceanic upwelling (1972)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-30
    Beschreibung: Observing the development of upwelling on the northeast coast of Africa by measuring ocean surface emission with infrared radiometers on Nimbus satellites is reported. Using the temperature of the ocean as telemetered by the satellite, the biological potential of an area is estimated, and consequently the highest potential for fisheries.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 14-17
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  • 66
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    Microwave emission of Arctic Sea ice (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The feasibility of carrying microwave radiometers on Nimbus E and F missions for sea ice surveys was studied in the arctic using aircraft. It was found that passive microwave signatures of Arctic Sea ice relate specifically to the structure and type of ice. It is concluded that a new tool for conducting ice surveys from aircraft and satellites with remote sensors was discovered.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 18-21
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  • 67
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    Electron impact ionization of H (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The results of theoretical calculations for the reactions between electrons and negative hydrogen atoms are discussed for an electron colliding with a negative hydrogen ion and neutralizing the hydrogen ion by stripping the loosely bound electron from it, and the two free electrons moving away. A semi-quantum description of the process is presented in which the target is described in terms of quantum mechanics, and the projectile electron is described in a classical fashion.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 58-62
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    Geological features in Wyoming from Nimbus 1 (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The identification of ground features in Nimbus photography by comparisons with geology, soils, and vegetation maps is discussed for the Wyoming-Colorado area. It is concluded that in a semiarid region, high topographic relief shows good coassociation with exposed geology and with vegetation and, to a lesser degree, with soils types. In lower, flatter basins, most tonal patterns are related to subtle variations in soil color and vegetation cover. It is thought that maps based on spectral parameters as the proper descriptor of surface features may be required.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 2-7
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  • 69
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    On the heterodyne method of detecting gravitational waves (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: A mathematical model on the heterodyne method of detecting gravitational waves is presented, using a dumbbell consisting of two masses situated in a plane and a plane-fronted gravitational wave traveling perpendicular to the plane. It is concluded that the detector sensitivity is not likely to be improved without employing very complicated and expensive super low temperature techniques.
    Schlagwort(e): GEOPHYSICS
    Materialart: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 45-46
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  • 70
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    Ground truth versus no ground truth (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The area of study was the southeastern Arizona test site and three areas within the site were studied in detail: Safford, Point of Pines, and Fort Apache-White River. These areas have terrain contrast ranging from flat arid regions to high alpine mountains. Data were obtained from the Apollo 9 photographic missions, high altitude aerial photography, and simulated ERTS-A data from high altitude aircraft. Various monoscopic and steroscopic devices were used to analyze the features, and film density variations were studied. No ground-based data were permitted. Thematic maps were prepared for geology, geomorphology, vegetation, hydrology, and soils. Interpreted boundaries were delineated, with no collaborative data used in the interpretation. Ground-based data were gathered during the overflight of high altitude aerial photography. A further study was made using the ground truth, and the data gathered on the ground were compared with original mapping. 80% to 85% of the interpretations in the areas checked were correct. It was proved that it is possible to monitor gross features of the vigor of crop lands and vegetative cover, to type soils and classify geologic features, and to determine hydrologic conditions.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 3 p
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  • 71
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    Preprocessing of multispectral data and simulation of ERTS data channels to make computer terrain maps of a Yellowstone National Park test site (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The possibility of improving the accuracy of terrain classification by preprocessing spectral data was investigated. Terrain maps were made using the following techniques: 1) preprocessing by scan angle function transformation, using the computer-selected best set of three channels; and 2) preprocessing by ratio transformation, using the specified ERTS data channels, simulated by fitting the spectral response of each of the 12 data channels to the ERTS channels by a set of weighting coefficients. By using a simple technique during printout, the maps were produced in color. The normalized scan angle function transformation resulted in the most accurate classification. The best ratio transformation for the Yellowstone Park data was the ratio of each channel to the sum of all channels. A supervised training program involving maximum likelihood decision for selecting the best spectrometer channels and similar techniques for digitizing the data of the analog magnetic tapes were used. Cloud shadows were recognized in addition to eight classes of terrain. Preprocessing of data resulted in more accurate maps, required fewer training areas (hence less preparation and computer time), and enabled much of the area formerly classified as shadow to be reclassified according to actual terrain type.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1.; 25 p
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  • 72
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    Regional land use studies (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Remote sensing technology and data from instrumented satellites and high altitude aircraft are proposed for mapping land use on a current national basis, for monitoring changes and trends, and for creating statistical models which can be manipulated to demonstrate the probable effects of proposed land use and of environmental changes over large areas. Both Apollo spacecraft and aircraft photography were used; the spacecraft pictures delineated the cropland and urban boundaries more clearly. A computer model is also proposed for statistical analysis and for printing out updated maps automatically; this model will include a data bank which can be updated rapidly with changes detected by the computer.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 9 p
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  • 73
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    A cursory examination of the sensitivity of the tropospheric range and Doppler effects to the shape of the refractivity profile (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-27
    Beschreibung: Ray tracing techniques for examination of refractivity profile sensitivity in tropospheric range and Doppler effects on profile shape
    Schlagwort(e): GEOPHYSICS
    Materialart: THE DEEP SPACE NETWORK, VOL. 1 15 FEB. 1971; P 22-30
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  • 74
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    Bearing strength of the lunar soil (1972)
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    Publikationsdatum: 2005-11-30
    Beschreibung: A discussion is presented on the bearing strength and bearing load-penetration relations in lunar soil. These were measured in air as a function of bulk density. It was found that the relation between bulk density and the logarithm of the bearing capacity is about linear. Shapes of the load vs penetration curves were observed to be similar to those obtained with particulate material of terrestrial origin.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA, Washington Analysis of Surveyor 3 Mater. and Phot. Returned by Apollo 12; p 227-232
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  • 75
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    Comparison of probe and radar ionosphere temperatures (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The discrepancy in temperature measurements of ionospheric electrons by Langmuir electrostatic probes, and radar backscatter are discussed. The discrepancy occurs at altitudes from 350 to 800km, and the probe temperatures are consistantly higher than the radar temperatures. It is concluded that the non-Maxwellian energy distribution provides an explanation for the altitude and the lower radar temperatures.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 43-45
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  • 76
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    Microwave measurements of sea state (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Passive microwave measurements were studied for determining sea state. It was found that the brightness temperature increases due to the foam produced by winds, and that the surface wind can be determined by the brightness temperature.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 22-27
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  • 77
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    An Eotvos experiment in earth orbit (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The gravitational interactions of mass energy stored in the weak interaction are being investigated. The magnitude of possible Eotvos anomalies, such as weak interaction, gravitational self-energy, spin-orbit interactions, and electromagnetic radiation reaction, are considered. A sensitive experiment was designed to determine whether weak interaction energy violates the equivalence principle. Factors to be considered in spacecraft design for the experiment are presented.
    Schlagwort(e): GEOPHYSICS
    Materialart: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 228-235
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  • 78
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    Observations of earth eigen vibrations possibly excited by low frequency gravity waves (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: A cryogenic gravity meter made of two parts, a magnetic suspension unit and a detection module, was used to monitor earth eigen vibrations. The magnetic field and field gradient are generated by energizing a set of superconducting coils made of niobium-zirconium alloy wire. The detection module is a double Josephson junction magnetometer. The output is printed on a chart recorder and later digitized using a computer; a Fourier transformation is performed on the accumulated data. The measurements of eigen vibrations are summarized in tabular and graphical representations.
    Schlagwort(e): GEOPHYSICS
    Materialart: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 47-53
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  • 79
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    Experiment M405: Tri-axis flux gate magnetometer (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: A tri-axis flux-gate magnetometer was used on four Gemini spacecraft for determination of the magnitude and direction of the local geomagnetic field with respect to the spacecraft. Conclusions derived from the data are not only important to the proton-electron spectrometer experiment, but also are of significance to any directional charged particle experiments that may be conducted. Even though the Gemini spacecraft was not clean magnetically, the data could be reduced to a form that supplied directional information on the magnetic field in relation to the spacecraft. Stray fields were the result of spacecraft structure, not the result of current flows that were produced within the spacecraft electrical systems. Efforts were made to reduce spacecraft stray fields and to facilitate the acquisition of more accurate data.
    Schlagwort(e): GEOPHYSICS
    Materialart: The Gemini Program: Phys. Sci. Expt. Sum.; p 153-168
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  • 80
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    ESRO study program for a space experiment on gravitation theories (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: ESRO is considering a space experiment which is the definition phase. A more complete utilization of space techniques, leading to highly accurate acceleration measurements in a heliocentric spacecraft, together with an improved laser signal propagation method (using a space-borne atomic clock), could substantially increase the validity of the gravitational time delay test during solar conjunction. Preliminary investigations of the primary required techniques were carried out. These studies included an orbit analysis, investigation of drag-free techniques, and studies of the time measuring instrument. These studies were used to define the framework of a space experiment on gravitation theories. A preliminary feasibility study of the mission is being undertaken.
    Schlagwort(e): GEOPHYSICS
    Materialart: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 236-241
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  • 81
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    Testing general relativity: Progress, problems, and prospects (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The results from ground-based experimental testing are presented. Prospects for improving these experiments are discussed. Radar echo time delays, perihelion advance and solar oblateness, time variation of the gravitational constant, and radio wave deflection are considered. Ground-based and spacecraft techniques are compared on an accuracy vs. cost basis.
    Schlagwort(e): GEOPHYSICS
    Materialart: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 136-147
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  • 82
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    The energy balance of wind waves and the remote sensing problem (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Measurements of wave growth indicate an energy balance of the wave spectrum governed primarily by input from the atmosphere, nonlinear transfer to shorter and longer waves, and advection. The pronounced spectral peak and sharp low frequency cut-off characteristic of fetch-limited spectra are explained as a self-stabilizing feature of the nonlinear wave-wave interactions. The momentum transferred from the atmosphere to the wind waves accounts for a large part of the wind drag. These findings are relevant for remote microwave sensing of the sea surface by backscatter and passive radiometry methods.
    Schlagwort(e): GEOPHYSICS
    Materialart: NOAA Sea Surface Topography from Space, Vol. 2; 55 p
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  • 83
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    Comments on ocean circulation with regard to satellite altimetry (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Basic features of sea surface topography are reviewed, to show those oceanographic results which may be of value to a geodetic satellite program: (1) the shape and magnitude of the large scale features of the mean sea surface, relative to a level surface; (2) the position and magnitude of the slopes across the western boundary currents, from a variety of data; (3) an estimate of the position of the geoid, tied into the U.S. leveling network; and (4) a documented change of 60 to 70 cm in mean sea level, with respect to the geoid, between the U.S. east and west coasts.
    Schlagwort(e): GEOPHYSICS
    Materialart: NOAA Sea Surface Topography from Space, Vol. 2; 17 p
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  • 84
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    The stable auroral red arc of October 31 - November 1, 1968 and its interaction with the neutral atmosphere (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Satellite observations of electron temperature and the topside electron density structure are used to calculate the red arc according to the thermal conduction model. In this model, energy from the magnetosphere flows in the electron gas along geomagnetic field lines into the ionosphere. This energy heats the ambient F-region electrons sufficiently to excite the oxygen atoms to the O I(1D) level by collisional impact giving rise to the 6300 A emission characteristic of the arc. For the 31 October/1 November 1968 red arc, the calculated emission rate, geographical position, and horizontal extent of the red arc are in agreement with the photometric data obtained by airglow observatories. Almost all of the energy conducted into the red arc is ultimately transferred to the neutral gas through elastic and inelastic collisions. This energy drives a large thermal cell and the circulation extends the influence of the arc thousands of kilometers beyond the region of direct heat input. The calculated neutral gas temperature response to electron heating within the arc is small.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA, Washington Phys. of the Space Environment; p 45-69
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  • 85
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    The composition of the upper atmosphere (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Miniature mass spectrometers were developed and were carried on sounding rockets to determine the composition of the upper atmosphere. Techniques have been developed that accurately correct for the velocity and spin of the moving vehicle. Above 120 km N2, O2, and Ar appear to be in diffusive equilibrium. Most He concentration measurements show a more rapid decline with altitude than predicted by diffusive equilibrium. Because of the highly reactive nature of atomic oxygen, measurements of this species by mass spectrometry are low by an unknown factor.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA, Washington Phys. of the Space Environment; p 129-145
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  • 86
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    Hydrology of the Niger River from Nimbus HRIR (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The seasonal changes in aspect of the Niger River in the Republic of Mali, West Africa, as seen in daytime imagery obtained by the high-resolution infrared radiometer on Nimbus 3 are described. The identification of different plants by their reflectance is shown to provide an ecological map that changes with time. It is concluded that Nimbus imagery provides an integrated view of the entire watershed on a daily basis.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 8-13
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  • 87
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    Air-sea interaction in the Pacific Ocean (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Daily Tiros and ESSA satellite television nephanalysis over the Pacific Ocean were collected, and monthly cloud charts drawn to study the interaction of tropical oceans with the atmosphere. The data were correlated with climatological data for rainfall and surface temperatures.
    Schlagwort(e): GEOPHYSICS
    Materialart: Significant Accomplishments in Sci., 1970; p 28-31
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  • 88
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    Reginal Geology of Hadley Rille, part F (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Local geology of Hadley Rille near the landing site of Apollo 15 is described. Orbital photography from the Hasselblad, metric, and panoramic cameras is used to study regional relationships of the rille. The shape of the rille due to various natural causes is examined, along with stratigraphic measurements of mare materials.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center Apollo 15 Prelim. Sci. Rept.; 5 p
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    Surface disturbances at the Apollo 15 landing site, part E (1972)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: High resolution panoramic photographs taken from 110 km orbits of the command service module show the lunar module structure on the moon as evidenced by reflected light and by the shadow. Before and after photographs of the landing site are presented; the increased brightness or halo is attributed to mare surface materials.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center Apollo 15 Prelim. Sci. Rept.; 3 p
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    Linear geologic structure and magic rock discrimination as determined from infrared data (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Color infrared photographs of the Beartooth Mountains, Montana show the distribution of mafic dikes and amphibolite bodies. Lineaments that cross grassy plateaus can be identified as dikes by the marked constrast between the dark rocks and the red vegetation. Some amphibolite bodies in granitic terrain can also be detected by infrared photography and their contacts can be accurately drawn due to enchanced contrast of the two types of rock in the near infrared. Reflectance measurements made in the field for amphibolite and granite show that the granite is 25% to 50% more reflective in the near infrared than in the visible region. Further enhancement is due to less atmospheric scattering than in the visible region. Thermal infrared images of the Mill Creek, Oklahoma test site provided information on geologic faults and fracture systems not obtainable from photographs. Subtle stripes that cross outcrop and intervening soil areas and which probably record water distribution are also shown on infrared photographs.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 12 p
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    Experimental applications of multispectral data to natural resource inventory and survey (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The feasibility of using multispectral, color, color infrared, thermal infrared imagery and related ground data to recognize, identify, determine and monitor the status of mineral ore and metals stockpiles is studied. An attempt was made to identify valid, unique spectral signatures of such materials for possible use under a wide variety of environmental circumstances. Research emphasis was upon the analysis of the multiband imagery from the various film-filter combinations, using density analysis techniques.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 33 p
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    Introductory comments on the USGS geographic applications program (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The third phase of remote sensing technologies and potentials applied to the operations of the U.S. Geological Survey is introduced. Remote sensing data with multidisciplinary spatial data from traditional sources is combined with geographic theory and techniques of environmental modeling. These combined imputs are subject to four sequential activities that involve: (1) thermatic mapping of land use and environmental factors; (2) the dynamics of change detection; (3) environmental surveillance to identify sudden changes and general trends; and (4) preparation of statistical model and analytical reports. Geography program functions, products, clients, and goals are presented in graphical form, along with aircraft photo missions, geography test sites, and FY-70.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 5 p
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    Tests of the equivalence principle and gravitation theory using solar system bodies (1971)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: The M sub g/M sub i ratio (ratio of body acceleration to gravitation field) of celestial bodies was measured. Deep probes of the post-Newtonian structure of gravitational theories are indicated. Kepler's third law is considered for the Sun-Jupiter system.
    Schlagwort(e): GEOPHYSICS
    Materialart: JPL Proc. of the Conf. on Exptl. Tests of Gravitation Theories; p 32-37
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    A review of application studies on Indian lands using NASA aerospace imagery (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Three remote sensing projects are being conducted on three different Indian reservations in eastern Arizona. On the Fort Apache Reservation, a multiband thermal and false color sensing of an Englemann spruce beetle infestation is being investigated on Mount Baldy, adjacent to a U.S. Forest Service proposed wilderness area. On the San Carlos Reservation, there is a joint USGS, EROS, and San Carlos tribe project to examine intensively a circular topographic feature noted on the Apollo 9 imagery. On the Papago Reservation, an EROS-funded contract will provide the Papago tribe with a report showing potential mineral areas, by comparing and correlating space imagery with high resolution imagery and aeromagnetic data.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 6 p
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    Geologic interpretation of Apollo 6 stereophotography from Baja California to west Texas (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Excellent space photography of parts of the southwestern United States and northwestern Mexico was obtained during the unmanned Apollo 6 spaceflight. Two features of this photography made it useful for geologic interpretations: its vertical stereocoverage and its exposure under a relatively low angle of solar illumination through an unusually cloud-free and clear atmosphere. The structural patterns, which were topographically enhanced by the longer shadows, were annotated on the photographs, in order to analyze their trends with respect to the continental tectonic framework, and to attempt to correlate the pattern with known copper or other base metal deposits. The annotated fracture patterns showed the regional trends and their distribution. The area studied was a 100- to 105-mile swath of terrain covering a total land area of approximately 60,000 square statute miles. The coverage began from a point centered on Punta Colnett on the Pacific coast of Baja California and extended to the Sacramento Mountains of New Mexico and west Texas.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 25 p
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    A study of passive microwave techniques applied to geologic problems (1970)
    In:  CASI
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    Publikationsdatum: 2005-11-30
    Beschreibung: Passive microwave techniques were applied to geologic problems, in order to establish the microwave properties of representative rocks and minerals, and to examine the feasibility of using microwave radiometry for geologic mapping problems. A review of microwave pertaining to geology was conducted, coupled with laboratory and field investigations of the microwave emission characteristics of various geologic features. The laboratory studies consisted of dielectric constant measurements of rocks and minerals. A majority of field investigations conducted in the western United States, involved the microwave emission charateristics of rock types, and a portion of the study was concerned with microwave properties of mineralized areas. Experiments were also conducted in the vicinity of a coal seam fire in Colorado and across the San Andreas Fault Zone near the Salton Sea, in Southern California.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 12 p
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    NASA TECHNICAL REPORTS
  • 97
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    Unbekannt
    Geography program, design, structure and operational strategy (1970)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-30
    Beschreibung: The geography program is designed to move systematically toward a capability to increase remote sensing data into operational systems for monitoring land use and related environmental change. The problems of environmental imbalance arising from rapid urbanization and other dramatic changes in land use are considered. These overall problems translate into working level problems of establishing the validity of various sensor-data combinations that will best obtain the regional land use and environmental information. The goal, to better understand, predict, and assist policy makers to regulate urban and regional land use changes resulting from population growth and technological advancement, is put forth.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spececraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 9 p
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 98
    facet.materialart.
    Unbekannt
    Environmental application of remote sensing methods to coastal zone land use and marine resources management (1970)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-30
    Beschreibung: The interrelationships of biophysical environmental systems are investigated. Social decision-making affecting the environments of a coastal megapolis are examined. Remote sensing from high altitude aircraft and satellites afforded a powerful and indepensible tool for inventory and planning for urban development. Repetitive low to medium altitude photography is also used for studying environmental dynamics, and to document the cultural impact of man on his environment.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., vol. 1; 9 p
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 99
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    Unbekannt
    Tides and tsunamis (1972)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-30
    Beschreibung: Although tides and tsunamis are both shallow water waves, it does not follow that they are equally amenable to an observational program using an orbiting altimeter on a satellite. A numerical feasibility investigation using a hypothetical satellite orbit, real tide observations, and sequentially increased levels of white noise has been conducted to study the degradation of the tidal harmonic constants caused by adding noise to the tide data. Tsunami waves, possibly a foot high and one hundred miles long, must be measured in individual orbits, thus requiring high relative resolution.
    Schlagwort(e): GEOPHYSICS
    Materialart: Sea Surface Topography from Space, Vol. 2; 30 p
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
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    Unbekannt
    Cracking of the lunar soil (1972)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-30
    Beschreibung: Rather than a pattern of cracks in an apparently flat surface, the Apollo 12 photographs suggest an irregular surface that consists of clods or fragments. The impression of flat tiles and crusting, obtained by monoscopic viewing, is an illusion. Instead, the lunar soil deforms and cracks in the same manner as homogeneous isotropic terrestrial soils of moderate bulk density, having a small amount of cohesion.
    Schlagwort(e): GEOPHYSICS
    Materialart: NASA, Washington Analysis of Surveyor 3 Mater. and Phot. Returned by Apollo 12; p 233-235
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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