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  • Chemistry  (63,133)
  • Analytical Chemistry and Spectroscopy  (7,572)
  • Organic Chemistry  (6,829)
  • Life and Medical Sciences  (5,275)
  • ASTROPHYSICS  (5,125)
  • 1980-1984  (40,101)
  • 1975-1979  (33,432)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-10-13
    Description: Picosecond spectroscopy is a relatively new field of science that utilizes ultrashort laser pulses to monitor events taking place in the 10(-12) second regime. The continuing development of picosecond spectroscopy has made possible the detection and measurement of the primary events in many physical and tiological processes. This article describes a currently used picosecond spectroscopy system that is capable of reliably recording picosecond events. Two areas of picosecond research are discussed; one concerns the interaction of electrons in fluids, and the second the primary events in vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rentzepis, P M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):174-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694523" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Electrons ; *Kinetics ; Lasers ; Protons ; *Retinal Pigments ; *Rhodopsin ; Spectrum Analysis/*methods ; Temperature ; *Vision, Ocular
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  • 2
    Publication Date: 1979-12-14
    Description: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉
    Keywords: *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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  • 4
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
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  • 12
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 13
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 15
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 17
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 18
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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  • 19
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-03-17
    Description: The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szmant, H H -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1173-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415363" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Cost-Benefit Analysis ; Education ; History, 20th Century ; International Educational Exchange ; Latin America ; *Research Support as Topic ; *Science/history ; United States
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  • 23
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 24
    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 27
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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  • 30
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 33
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 34
    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 35
    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-04-07
    Description: Glucose reacts nonenzymatically with the NH2-terminal amino acid of the beta chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin AIc. Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin AIc in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin AIc is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunn, H F -- Gabbay, K H -- Gallop, P M -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):21-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635569" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Glucose/metabolism ; Chemical Phenomena ; Chemistry ; Diabetes Complications ; Diabetes Mellitus/*blood/diagnosis ; Diphosphoglyceric Acids/blood ; Glycosides/blood ; Glycosuria/etiology ; Hemoglobin A/*metabolism ; Hemoglobins/*analysis/*metabolism ; Humans ; Kinetics ; Oxygen/blood ; Structure-Activity Relationship
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  • 37
    Publication Date: 1979-06-08
    Description: It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanggord, R J -- Tyson, C A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1081-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36659" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetates ; Chemical Phenomena ; Chemistry ; *Chlorine ; Dicarboxylic Acids ; Environmental Pollutants ; Hydrogen-Ion Concentration ; *Imino Acids ; Mutagens ; *Nitrilotriacetic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218287" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen Cyanide ; *Peptides
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 41
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    Publication Date: 2006-08-09
    Description: Observations of cosmic and gamma radiation by SAS-2 satellite are summarized and analyzed to determine processes responsible for producing observed galactic radiation. In addition to the production of gamma rays in discrete galactic objects such as pulsars, there are three main mechanisms by which high-energy (greater than 100 MeV) radiation is produced by high-energy interactions involving cosmic rays in interstellar space. These processes, which produce what may be called diffuse galactic gamma-rays, are: (1) the decay of pi mesons produced by interactions of cosmic ray nucleons with interstellar gas nuclei; (2) the bremsstrahlung radiation produced by cosmic ray electrons interacting in the Coulomb fields of nuclei of interstellar gas atoms; and (3) Compton interactions between cosmic ray electrons and low-energy photons in interstellar space.
    Keywords: ASTROPHYSICS
    Type: The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 315-346
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  • 42
    Publication Date: 2006-08-09
    Description: Gamma ray astronomy is now beginning to provide a new look at the galactic structure and the distribution of cosmic rays, both electrons and nucleons, within the galaxy. The observations are consistent with a galactic spiral-arm model in which the cosmic rays are linearly coupled to the interstellar gas on the scale of the spiral arms. The agreement between the predictions of the model and the observations for regions of the plane where both 21-cm and 2.6-mm CO surveys exist emphasizes the need to extend these observations to include the entire plane. Future gamma-ray observations with more sensitivity and better angular resolutions, combined with these radio surveys, should shed new light on the distribution of cosmic rays, the nature of the galaxy, and the location and intensity of the spiral arms.
    Keywords: ASTROPHYSICS
    Type: The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 301-314
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  • 43
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    In:  CASI
    Publication Date: 2006-08-09
    Description: The density distributions of pulsars in luminosity, period, Z-distance, and galactocentric distance were derived, using a uniform sample of pulsars detected during a 408-MHz pulsar survey at Jodrell Bank. There are indications of a fine-scale structure in the spatial distributions and evidence that there is a general correlation with other galactic populations and the overall spiral structure. The electron layer in our galaxy is shown to be wider than the pulsar layer and uniform on a large scale. The number of pulsars in the galaxy has been estimated and used to derive the pulsar birthrate.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 265-282
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  • 44
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    In:  CASI
    Publication Date: 2006-08-09
    Description: Thermal radiation associated with the explosion of supernovae is investigated. High temperature is required to produce copious gamma radiation of this sort. It appears that type 11 supernovae do not release much of their energy as gamma ray continuum radiation.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 257-264
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  • 45
    Publication Date: 2006-08-09
    Description: The degree of saturation characterizing low altitude emission observations of H(I) and the optical depth corrections to the derived column and volume densities are discussed. The amount of fine-scale velocity and spatial structure diluted by the instrumental limitations of the presently available surveys are described. The general problem of detailed mapping of H(I) in the galaxy is explored. Comparison is made between the distribution of H(I) and that of CO and several other galactic tracers. Atomic hydrogen is unique in its distribution, instead of being typical of many Population I constituents. As defined by atomic hydrogen, the galactic disk has a diameter fully twice as large as that defined by the ionized and molecular states of hydrogen, as well as by other molecules, supernova remnants, pulsars, gamma-radiation, synchroton radiation, and the youngest stars. It is also less confined to the galactic equator than most of the other constituents. The degree of small scale structure apparent in the molecular observations is much greater than that in the H(I) observations.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 163-188
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  • 46
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    In:  CASI
    Publication Date: 2006-08-09
    Description: Data from the SAS-2 high-energy gamma-ray experiment reveal the existence of four pulsars emitting photons above 35 MeV. An attempt is made to explain the gamma-ray emission from these pulsars in terms of an electron-photon cascade that develops in the magnetosphere of the pulsar. Although there is very little material above the surface of the pulsar, the very intense magnetic fields (10 to the 12th power gauss) correspond to many radiation lengths which cause electrons to emit photons by magnetic bremsstrahlung and which cause these photons to pair-produce. The cascade develops until the mean photon energy drops below the pair-production threshold which is in the gamma-ray range; at this stage, the photons break out from the source.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 109-118
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  • 47
    Publication Date: 2006-08-09
    Description: Considerations made in developing a model of pulsars are explored. Observational data seems to support the argument that pulsar magnetospheres may contain large masses of plasma. The cascade process resulting from pair creation enables one to interpret the X-ray emission from the Crab and Vela pulsars as synchrotron radiation. On the other hand, the optical radiation from the Crab pulsar is best understood as coherent curvature radiation. Radio emission is interpreted as curvature radiation produced by charge bunches moving along magnetic-field lines. Certain tests of this model are proposed.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 99-108
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  • 48
    facet.materialart.
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    In:  CASI
    Publication Date: 2006-02-14
    Description: The specific objectives of this experiment are to establish the population and size distribution of meteoroids in the mass range from 10 to the minus 10 power to 10 to the minus 4 power G, to establish the current population of man-made debris in the same mass range, and to obtain data on the physical properties (composition and density) of meteoroids.
    Keywords: ASTROPHYSICS
    Type: Long Duration Exposure Facility (LDEF); p 136-137
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  • 49
    Publication Date: 2006-02-14
    Description: The objective of this experiment is to study interplanetary dust, variously referred to as cosmic dust, cometary dust, zodiacial dust, or meteoric dust particles. Specific objectives are to obtain information regarding particle mass and velocity, and to undertake correlative analyses with other experiments, both on LDEF or near the time of the LDEF flight.
    Keywords: ASTROPHYSICS
    Type: Long Duration Exposure Facility (LDEF); p 134-135
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  • 50
    Publication Date: 2006-02-14
    Description: The primary objective of this experiment is to investigate the feasibility of future missions of multilayer thin-film detectors acting as energy sorter to collect micrometeoroids, if not in their original shape, at least as fragments suitable for chemical analysis. It is expected that this kind of particle collector will help in solving one of the most puzzling topics in cosmic-dust studies: the mineralogical and chemical composition of the particles. This is a matter of great interest in the study of the origin and evolution of the solar system.
    Keywords: ASTROPHYSICS
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 124-126
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  • 51
    facet.materialart.
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    In:  CASI
    Publication Date: 2006-04-18
    Description: Investigation of blue-sensitive photographs of HDE 226868 = Cygnus X-1 reveal no (+ or - 0.06 mag) long-term changes in brightness since the beginning of the century nor any abrupt intensity changes similar to what was observed at X-ray and radio frequencies. From the double sinusoidal fluctuation with 5.6 day period, an attempt is made to derive a more precise value for the orbital period, but problems are encountered and discussed. There exists evidence that the amplitude of the orbital fluctuations is increasing slowly with time.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 513-520
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  • 52
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    In:  CASI
    Publication Date: 2006-04-18
    Description: Spectroscopic observations of Sco X-1 show conclusively that the emission lines vary in radial velocity with a period of .787 sup d + or - .006 and a full range of approximately 120 km/s. The period is identical to that found by Gottleib et al (1975) from photometric data; light minimum occurs when the emission line region is at superior conjunction. The observations indicate that the emission lines originate in an accretion disk surrounding a neutron star which is orbiting about a normal, although somewhat evolved companion. The light variation is due to a heating effect on the non degenerate star, viewed at a small inclination angle.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 683-690
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  • 53
    Publication Date: 2006-04-18
    Description: Data which indicate a periodicity of 17d from Cyg X-3 are reviewed. The data are taken from the Ariel 5 satellite All-Sky Monitor and the Sky Survey Experiment.
    Keywords: ASTROPHYSICS
    Type: X-ray Binaries; p 245-253
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  • 54
    Publication Date: 2006-04-18
    Description: The steep high energy cutoff observed in the spectrum for Her X-1 is analyzed in terms of the severely modified Thomson scattering that dominates the radiative transfer in a highly magnetized plasma near the surface of a neutron star. The data are shown to indicate a field of about 10 to the 13th power G near the magnetic poles and the stopping of accreting matter by nuclear collisions in the neighboring plasma.
    Keywords: ASTROPHYSICS
    Type: X-ray Binaries; p 113-118
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  • 55
    Publication Date: 2006-04-18
    Description: Weak 0.28-keV radiation was observed from Her X-1 5 days before turn-on in the 35 day cycle. The observations were made from an Aerobee rocket. The 0.28-keV intensity is about 1/25 that observed during the on phase. Some evidence for X-rays above 1 keV is also present, and it is possible that the spectrum is different only in intensity from the spectrum in the on phase. The radiation may be X-rays from the vicinity of the neutron star, scattered by ionized material in the inner accretion disk, or may be thermal radiation from the inner accretion disk, or both.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 127-139
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  • 56
    Publication Date: 2006-04-18
    Description: The orbital elements of the 3U 0900-40 binary system were determined by measuring the variations in the arrival times of the 283-second X-ray pulses. The best-fit values of the system parameters and their 95% confidence limits are listed.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 661-667
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  • 57
    Publication Date: 2006-04-18
    Description: From a radial velocity study of lines of He I and the heavier ions of HD 77581 (=Vela X-1), orbital elements for this X-ray binary system are derived. Together with the orbital elements given by Rappaport and McClintock from X-ray pulsar results, this enables determination of masses for both the X-ray and the early type supergiant component.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 643-657
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  • 58
    facet.materialart.
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    Publication Date: 2006-04-18
    Description: There is a standard model for X-ray sources comprising a binary system containing a compact star and powered by mass accretion. It can be argued that the majority and perhaps all the galactic X-ray sources are of this kind. Three kinds of sources which may be qualitatively different from these are discussed: namely, low luminosity sources such as 3U0352 + 30, the sources associated with the globular clusters, and the transient X-ray sources.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 669-676
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  • 59
    facet.materialart.
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    In:  CASI
    Publication Date: 2006-04-18
    Description: It is shown that the broad emission features in the spectrum of HD 153919 are associated with the X-ray secondary and not significantly with the primary star. When the primary is at maximum velocity towards us, the HeI line lambda 4471 develops a blue shifted secondary component with a velocity of -470 km/sec relative to the primary.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 569-574
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  • 60
    Publication Date: 2006-04-18
    Description: Equipotential surfaces incorporating the effect of radiation pressure were computed for the X-ray binaries Cen X-3, Cyg X-1 = HDE 226868, Vela XR-1 = 3U 0900-40 = HD 77581, and 3U 1700-37 = HD 153919. The topology of the equipotential surfaces is significantly affected by radiation pressure. In particular, the so-called critical Roche (Jacobian) lobes, the traditional figure 8's, do not exist. The effects of these results on modeling X-ray binaries are discussed.
    Keywords: ASTROPHYSICS
    Type: X-ray Binaries; p 499-511
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  • 61
    facet.materialart.
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    In:  CASI
    Publication Date: 2006-04-18
    Description: Absorbing material in Cygnus X-1 jitters near the line joining the two stars, out of the orbital plane is described. Three looks with the Copernicus satellite at Cygnus X-1 have produced four examples of absorption dips (decreases in the 2 to 7 keV flux from Cygnus X-1 with an increase of spectral hardness consistent with photoelectric absorption).
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 425-427
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  • 62
    facet.materialart.
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    In:  CASI
    Publication Date: 2006-04-18
    Description: Radio observations of Cyg X-1 (HDE 226868) taken during the period May-June 1975 at 2,695 and 8,085 MHz are presented and discussed in the context of both the previous four years of data at these frequencies and subsequent data for September-October 1975. The data show that the radio event was a transient one with a time scale of the order of a few to several weeks, and that the observed radio decay was qualitatively similar to the observed decay of the enhanced X-ray state.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 495-497
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  • 63
    Publication Date: 2006-01-12
    Description: Observations of the galactic longitude and latitude distributions of gamma = 2.6 mm CO emission are presented. Analysis of this spectral line data yields the large scale distribution of molecular clouds in the galactic disk and their z-distribution out of the disk. Strong maxima in the number of molecular clouds occur in the galactic nucleus and at galactic radii 4-8 kpc. The peak at 4-8 kpc correlates well with a region of enhanced 100 Mev gamma ray emissivity. This correlation strongly supports the conclusion that the gamma rays are produced as a result of cosmic ray interactions in molecular H2 clouds rather than HI. One important implication of this is that the interstellar magnetic field lines to which cosmic rays are confined must therefore not be excluded from these dense clouds. The width of the cloud layer perpendicular to galactic plane between half density points is 105 + or - 15 pc near the 5.5 kpc peak. The total mass of molecular gas in the interior of the galaxy exceeds that of atomic hydrogen.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 163-176
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  • 64
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    In:  CASI
    Publication Date: 2006-01-16
    Description: The use of the Space Telescope in the determination of the distances of galaxies is examined. The Space Telescope can check the local extragalactic distance scale to within 10-15 percent. The determination of relative distances of cosmic standard candles, viz. brightest M-supergiants and SNe I in E galaxies, is discussed. The M-supergiants map the velocity field out to v sub o approx. 3000 km s(-1) thus providing a firm basis for the determination of H sub o (global) from local distances, and the possibility to derive precise distances of all nearby field galaxies from their recession velocities. Photometry of the SNe I out to z = 0.5 leads to a direct determination of q sub o via the Hubble diagram, and the form of their light curves offers a fundamental test on the nature of redshifts. Other calculations are discussed.
    Keywords: ASTROPHYSICS
    Type: NASA. Marshall Space Flight Center Sci. Res. with the Space Telescope; p 263-293
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  • 65
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    Publication Date: 2006-01-12
    Description: Observations of the diffuse far infrared flux from the galactic plane as well as far infrared measurements of the properties of dense molecular clouds, when combined with recent high-energy gamma ray measurements and radio observations of carbon monoxide, can yield new information about the total mass of molecular clouds, the large scale structure of the inner galaxy, and the density of cosmic rays. These observations are discussed.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 222-238
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  • 66
    Publication Date: 2006-01-16
    Description: Physical processes within quiescent as well as disturbed flows of solar wind plasma, energetic particles, and magnetic and electric fields from the Sun are considered. Specifically, travelling interplanetary phenomena to be studied during the years of the solar maximum of solar cycle 21 are covered. It is noted that predictions, while needed for long range, logistical planning, is secondary to the requirements of synoptic real time monitoring over a wide range of particle energies and spectral bandwidths.
    Keywords: ASTROPHYSICS
    Type: NASA. Marshall Space Flight Center Solar-Terrest. Predictions Proc., Vol. 2; p 340-345
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  • 67
    facet.materialart.
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    Publication Date: 2006-02-14
    Description: Results associated with exact solution of the Einstein-Boltzmann and Einstein-Maxwell-Boltzmann equations are presented. The generalization of Ehler's killing vector approach for the distribution function to charged particles is considered.
    Keywords: ASTROPHYSICS
    Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 21 p
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  • 68
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    Publication Date: 2006-01-12
    Description: From satellite measurements of ultraviolet spectra of stars, an average density of approximately 1.1/cu cm for hydrogen atoms, in both atomic and molecular form, is estimated for regions of space along the galactic plane within about 1 kpc of the sun. About 20% of the atoms are bound in molecular form although this figure is uncertain since the ultraviolet measurements avoid the very dense interstellar clouds. Discrete values for this percentage are observed to vary markedly; regions with less than average density seem to have fractional abundances of H2 several orders of magnitude lower than average. A ratio of CO/H is observed for regions in front of stars observed by the Copernicus satellite.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 239-263
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  • 69
    Publication Date: 2006-01-12
    Description: Several current problems concerning the overall distribution of hydrogen in the galaxy are discussed in general terms. These problems include the degree of saturation characterizing low-latitude emission observations of HI, and the optical-depth corrections to the derived column and volume densities; the amount of fine-scale velocity and spatial structure diluted by the instrumental limitations of the presently available surveys; and the general problem of detailed mapping of the HI in the galaxy. Comparison is made between the distribution of HI and that of CO and several other galactic tracers. The galactic disk as defined by atomic hydrogen has a diameter fully twice as large as that defined by the ionized and molecular states of hydrogen, as well as by other molecules, supernova remnants, pulsars, gamma radiation, synchroton radiation, and the youngest stars. It is also less confined to the galactic equator than most of the other constituents. The degree of small-scale structure apparent in the molecular observations is much greater than in the HI observations. Parameters describing the small-scale structure were determined using Monte Carlo techniques to simulate the observations.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 177-205
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  • 70
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    Publication Date: 2006-01-12
    Description: The prospect that density waves and galactic shock waves are present on the large-scale in disk-shaped galaxies has received support in recent years from both theoretical and observational studies. Large-scale galactic shock waves in the interstellar gas are suggested to play an important, governing role in star formation, molecule formation, and the degree of development of spiral structure. Through the dynamics of the interstellar gas and the galactic shock wave phenomenon, a new insight into the physical basis underlying the morphological classification system of galaxies is suggested.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Struct. and Content of the Galaxy and Galactic Gamma Rays; p 128-162
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  • 71
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    Publication Date: 2006-01-16
    Description: Three examples that illustrate the expected role of the Space Telescope in cosmological investigations are described addressing the distribution of globular star clusters, universe expansion, and other classical cosmological problems.
    Keywords: ASTROPHYSICS
    Type: NASA. Marshall Space Flight Center Sci. Res. with the Space Telescope; p 295-312
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  • 72
    Publication Date: 2006-01-16
    Description: Theories describing the central regions of nonthermal extragalactic sources (radio galaxies, Seyfert nuclei, quasars, etc.) are examined in the light of the experimental possibilities afforded by the Space Telescope. In particular, the theory which proposes the accretion of stars or gas onto a black hole as the explanation of the central engine is discussed. Planned observations directed towards the problem of the mass, size, and structure of the central engine, and the phenomenological questions regarding the general environment of the central engine are outlined.
    Keywords: ASTROPHYSICS
    Type: NASA. Marshall Space Flight Center Sci. Res. with the Space Telescope; p 197-214
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  • 73
    Publication Date: 2006-01-16
    Description: The stellar dynamics of globular clusters are addressed in terms of luminosity functions, chemical topics, and dynamical topics
    Keywords: ASTROPHYSICS
    Type: NASA. Marshall Space Flight Center Sci. Res. with the Space Telescope; p 139-150
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  • 74
    Publication Date: 2006-01-12
    Description: The most important properties of the interplanetary medium are its interplanetary plasma (solar wind), magnetic field, galactic and solar cosmic rays, and micrometeorite material. Also considered is electromagnetic radiation from the sun, stars, and the galaxy.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington Found. of Space Biol. and Med., Vol. 1; p 32-111
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  • 75
    Publication Date: 2006-01-12
    Description: The origin of life on earth is seen arising as a natural consequence of a long series of physical and chemical processes taking place in association with evolution of the universe. The present theory is that any premordial earth atmosphere, resulting from accumulation from the primitive solar nebula, was probably swept away by the very intensive T Tauri stage of the solar wind. Subsequently, the present atmosphere and oceans of the earth were outgassed from the interior. Biochemical components of the gases were mainly water vapor and carbon dioxide.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington Found. of Space Biol. and Med., Vol. 1; p 3-31
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  • 76
    Publication Date: 2006-02-14
    Description: The objectives of this experiment are to collect and isotopically analyze interstellar gas atoms around the orbit of the Earth for the purpose of obtaining new data relevant to understanding nucleosynthesis, and to study the dynamics of the interstellar wind inside the heliosphere and the isotopic composition of the interstellar medium outside the heliosphere. The experiment hardware will act as a set of simple cameras with high-purity copper-beryllium collecting foils serving as the film. The experiment housing will mount and thermally control the foils, establish the viewing angles and viewing direction, provide baffling to reject ambient neutral particles, provide a voltage grid to reject ionospheric charged particles, sequence collecting foils, control exposure times, and protect the foils from contamination during the deployment and retrieval of the LDEF. After being returned to Earth, the entrapped atoms can be analyzed by mass spectroscopy to determine the relative abundance of the different isotopes of helium and neon. An attempt will also be made to detect argon.
    Keywords: ASTROPHYSICS
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 98-100
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  • 77
    Publication Date: 2006-04-18
    Description: From observations of Vela X-1 with the MSSL 2.5-7.5 keV detector onboard Copernicus, the behavior of the source can be characterized by three phases: (1) high intensity, (2) low intensity, and (3) eclipse. Combining data from the 1972 Uhuru observations with eclipse observation yields a binary period of 8.963 + or - 0.001 days with zero phase on 1975 Feb. 6.97 + or - 0.04 UT. The low intensity phase is interpreted as being due to increased absorption in an accretion wake traveling across the line of sight (the spectral slope remains relatively constant throughout the cycle). Another period of enhanced absorption immediately after exit from eclipse may be due to a bow shock. Comparison of the two observations suggests that these structures vary from cycle to cycle and, since the orbital period is long, probably during each cycle.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 629-642
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  • 78
    Publication Date: 2006-04-18
    Description: The temporal behavior of three new events of modulated optical emission from Cyg X1, detected in July 1975, is presented. Short time periodicities in the optical band are investigated. Single photon pulses from the photomultiplier are recorded on magnetic tape together with a very accurate 1 kHz reference frequency. During playback of the tape, the reference signal gives a 1 ms timing to a scaler interfaced with a small processor and the number of photon per millisecond is recorded on a digital tape.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 485-492
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  • 79
    Publication Date: 2011-08-16
    Description: Stars in the range of 4 to 8 solar masses are known to develop degenerate carbon-oxygen cores of about 1.4 solar masses. Arguments are presented why, contrary to past assumption, carbon ignition may not lead to the formation of a detonation wave. Rather, an initially subsonic burning front results which subsequently may be brought under control by adiabatic expansion. This dynamic phase leads to a centrally incinerated and expanded core. The loosely bound red-giant envelope is ejected to form an extended nebula. Neutrino cooling of the core finally induces collapse. Provided that sufficient energy is liberated in the dynamic formation of a neutron star, a supernova event will result. The distended nebula is ideally suited for the production of the visible supernova light curves. Thus, carbon nondetonation may give a viable alternative evolution to supernovae that avoids the impasse encountered by the detonation-disrupted models.
    Keywords: ASTROPHYSICS
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  • 80
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    Publication Date: 2011-08-16
    Description: A model for the motion of flare-generated shocks through interplanetary streams is presented which illustrates the effects of a stream-shock interaction on the shock strength and geometry. It is a gasdynamic calculation based on Whitham's (1958) method and on an empirical approximation for the relevant characteristics of streams. The results show that the Mach number of a shock can decrease appreciably to near unity in the interaction region ahead of streams and that the interaction of a spherically symmetric shock with a spiral-shaped corotating stream can cause significant distortions of the initial shock-front geometry. The geometry of a shock discussed by Lepping and Chao (1972) is qualitatively explained by this model.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research; 80; Oct. 1
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  • 81
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    Publication Date: 2011-08-16
    Description: It is shown that application of standard MHD arguments to hydromagnetic waves observed in the Crab Nebula dramatically improves the upper bound on photon rest mass. The standard argument that massive photons are governed by the Phoca field equations is outlined and applied to wisp features (identified as hydromagnetic waves) observed in the Crab. The results imply an upper limit for the photon rest mass of between 3 by 10 to the -54th power and 3 by 10 to the -53rd power gram, which is smaller than the best previous limits by a factor of 10,000 to 100,000. It is noted that although the present limit is probably valid in order of magnitude, some doubt remains since there are inconsistencies in the standard arguments.
    Keywords: ASTROPHYSICS
    Type: Physical Review Letters; 35; Oct. 27
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  • 82
    Publication Date: 2011-08-16
    Description: The eigenvalue method to calculate models for periodically pulsating stars is used to study the stability of the resulting oscillations. This paper discusses results for a series of RR Lyrae models.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center Cepheids Modeling; p 129-135
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  • 83
    Publication Date: 2011-08-16
    Description: Numerical models of variable stars are established, using a nonlinear radiative transfer coupled hydrodynamics code. The variable Eddington method of radiative transfer is used. Comparisons are for models of W Virginis, beta Doradus, and eta Aquilae. From these models it appears that shocks are formed in the atmospheres of classical Cepheids as well as W Virginis stars. In classical Cepheids, with periods from 7 to 10 days, the bumps occurring in the light and velocity curves appear as the result of a compression wave that reflects from the star's center. At the head of the outward going compression wave, shocks form in the atmosphere. Comparisons between the hydrodynamic motions in W Virginis and classical Cepheids are made. The strong shocks in W Virginis do not penetrate into the interior as do the compression waves formed in classical Cepheids. The shocks formed in W Virginis stars cause emission lines, while in classical Cepheids the shocks are weaker.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center Cepheid Modeling; p 71-83
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  • 84
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    Publication Date: 2011-08-16
    Description: Color observations of Cepheids can be interpreted by a color effective temperature relation to give different T sub e values for each kind of mean color. Here, theoretical colors from numerical integrations of Cepheid pulsations are used to determine the proper method of taking the color mean in order to get, by the color T sub e relation, the correct nonpulsating T sub e.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center Cepheid Modeling; p 43-55
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  • 85
    Publication Date: 2011-08-16
    Description: The observed He II line spectrum in zeta Pup is compared with that predicted from model atmospheres in an attempt to establish the parameters (effective temperature, log g) which characterize the model that best represents this star's atmosphere. The study is conducted by compiling equivalent widths of the He II lines in the series (n = 2,3,4,5) and comparing them with predictions from plane-parallel static model atmospheres using a non-LTE theory of line formation. Good agreement between observation and prediction for a model atmosphere with an effective temperature of 50,000 K and log of 4.0 is found for the upper members of the n = 3 and n = 5 series, but discrepancies are found for the two lines of the n = 2 series and the upper members of the n = 4 series. It is shown that the n = 4 level appears to be more overpopulated at moderate atmospheric depths than the non-LTE calculations with plane-parallel layers indicate. It is suggested that this may be due to an overlap of the H and He II lines in the even-even series caused by macroturbulent velocities of the hydrogen and helium atoms.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 200; Sept. 15
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  • 86
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    Publication Date: 2011-08-16
    Description: Solar radiation pressure can cause rotational bursting and eventual elimination from the solar system of asymmetric dust particles by a windmill effect. The life span against this process for metallic particles with radii of 0.00001-0.01 cm ranges from 10 to 10,000 years. The effects of magnetic spin damping have been considered in this estimate. This depletion mechanism works faster than the traditional Poynting-Robertson effect by approximately one order of magnitude for metallic particles and about two-orders of magnitude for nonmetallic particles.
    Keywords: ASTROPHYSICS
    Type: Geophysical Research Letters; 2; Sept
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  • 87
    Publication Date: 2011-08-16
    Description: The heliocentric radial distribution of the flux of hyperbolic cosmic dust particles, as measured by the Pioneer 8 and 9 spacecraft, is closely related to the radial variation of the spatial density of source or parent meteoroids. Within the limits of the experimental and theoretical uncertainties the spatial density of parent meteoroids, as deduced from the hyperbolic cosmic dust data, is found to be increasing with increasing heliocentric distance in the neighborhood of one AU. Other recent experimental evidence confirms this result. The new results also suggest that the ratio of the areal density of submicron-sized craters to the areal density of millimeter-sized craters will be less on the north-south faces of lunar rocks than on the east-west faces of the same rocks. The change in ratio is not as large as previously thought. It is noted that the solar system is not presently contributing significant amounts of dust to the interstellar medium though it may once have done so.
    Keywords: ASTROPHYSICS
    Type: Planetary and Space Science; 23; Oct. 197
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  • 88
    Publication Date: 2011-08-16
    Description: The Second Small Astronomy Satellite (SAS-2) high-energy (in excess of 35 MeV) gamma-ray telescope has detected pulsed gamma-ray emission at the radio period from PSR 0833-45, the Vela pulsar, as well as an unpulsed flux from the Vela region. The pulsed emission consists of two peaks following the single radio peak by about 13 ms and 48 ms. The luminosity of the pulsed emission above 100 MeV from Vela is about 0.1 that of the pulsar NP 0532 in the Crab nebula, whereas the pulsed emission from Vela at optical wavelengths is less than 0.0002 that from the Crab. The relatively high intensity of the pulsed gamma-ray emission, and the double peak structure, compared with the single pulse in the radio emission, suggest that the high-energy gamma-ray pulsar emission may be produced under different conditions from those at lower energies.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 200; Sept. 1
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  • 89
    Publication Date: 2011-08-16
    Description: It is noted that the general intrinsic interpretation of QSO absorption redshifts predicts a high probability of clustering for the expulsion velocities of clouds ejected from a QSO core and that a correlation function has been defined which depends on the probability of clustering of three or more expulsion velocities. A test of this correlation is formulated which utilizes data on pairs of QSOs with similar emission redshifts and at least three well established absorption redshifts with corresponding expulsion velocities greater than 0.02c. It is shown that the correlation should be positive (maximum value +100%) if the absorption systems are intrinsic and correlated, zero if there is no physical connection among these systems, and negative if a strong anticorrelation exists or QSOs tend to eject one or two clouds at well separated characteristic velocities. Data on five QSOs are analyzed, and large positive values are obtained for the correlations.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 200; Sept. 1
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  • 90
    Publication Date: 2011-08-16
    Description: The possibility that the origin of extinct radioactivities depended on their living long enough for grains to form in the expanding nucleosynthetic envelope, rather than on their living long enough for meteorites to form, is examined. As an example, the interpretation of Na-22 as a detectable extinct radioactivity, with a half life of only 2.6 years, is explored and related to Ne-22 occurrence. Similar arguments involving He-4, Ar-40, K-40, K-41, and calcium, titanium, chromium, manganese, iron, nickel, and cobalt isotopes are briefly presented.
    Keywords: ASTROPHYSICS
    Type: Nature; 257; Sept. 4
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  • 91
    Publication Date: 2011-08-16
    Description: A multiple shock system was observed upstream (0.13 AU) of the earth by Pioneer 9 on February 2, 1969. The same system was observed at earth by Ogo 5 and was reported separately in the literature. This paper compares the two sets of observations in still further detail. Both magnetic-field and plasma data are used in a least-squares best-fit method to compute the characteristics of the fast forward shock wave (Pioneer 9 only) and two fast reverse shock waves. Nearly all major features (shock, piston, and tangential discontinuity) retained their characteristics during the transit of the shock ensemble from Pioneer 9 to Ogo 5. The genesis of the ensemble is believed to be due to a complex stream-stream interaction. A substantial density increase (including a large rise of alpha/proton abundance) at Ogo 5, but unobserved at Pioneer 9, is explained by a sudden meridional shift to a flow from below the ecliptic plane while the streams were en route to earth. This study demonstrates a spatial and temporal plasma inhomogeneity which is superimposed on the persistent major features.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research; 80; Aug. 1
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  • 92
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    Publication Date: 2011-08-16
    Description: OAO-2 spectral scans of several early-type main-sequence stars and the shell star zeta Tau are analyzed to derive a representative UV spectrum for B-type supergiants. The absorption lines in the spectra of the B-type supergiants are shown to be stronger than those in main-sequence stars and to have a broad pointed feature at 1720 A that is constant in all such stars. The UV resonance lines of C IV, N V, Si III, and Si IV are found to be displaced toward the shorter wavelengths by velocities of up to 1800 km/s, indicating an escaping atmosphere. For B5 stars, the atmosphere is estimated to be expanding at about 120 km/s. The spectrum of eta CMa (B5Ia) is found to be well represented by the LTE theory of line formation, the presence of a stationary circumstellar shell, and a slowly expanding model atmosphere.
    Keywords: ASTROPHYSICS
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  • 93
    Publication Date: 2011-08-16
    Description: Ten interstellar lines in the vacuum UV spectrum of delta Sco are analyzed which were recorded on rocket spectrograms. Two cloud components are resolved which have Doppler widths of 1.55 km/sec (larger cloud) and 2.16 km/sec (smaller cloud). Column densities are derived for C I, C II, N I, O I, Al II, Si II, and Fe II, and abundances relative to atomic hydrogen are determined from them. Silicon and iron are found to be slightly overabundant relative to the solar abundances, while the other elements are underabundant by factors ranging from 1.8 to 8.6. Mean cloud densities of 250 and 150 per cu cm (for the larger and smaller clouds, respectively) are determined, and the average ratios of electron density to hydrogen-atom density are derived using the column densities of C I and C II. It is shown that the iron abundance can be decreased to less than the solar abundance by doubling the velocity dispersion of the iron ions.
    Keywords: ASTROPHYSICS
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  • 94
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    Publication Date: 2011-08-16
    Description: The validity of imposing a zero chemical potential for neutrinos in hydrodynamic calculations of collapsing supernovae is investigated in the diffusion approximation of neutrino transport. A coupled system of equations is solved for neutrino and energy diffusion fluxes as well as lepton diffusion in a collapsing supernovae ambient medium, and the results indicate a substantial growth in the neutrino chemical potential for densities greater than 10 to the 12th power gm/cu cm. The rate of energy transport is shown to be significantly affected by increases in Fermi integrals and chemical-potential gradients accompanied by decreases in temperature, and the extent of neutrino particle/antiparticle reactions is found also to affect energy diffusion rates. It is concluded that the photon-like behavior usually assumed for neutrinos may be incorrect and that an extension of the Sn transport approximation to include lepton characteristics is necessary for a definitive answer to the question of neutrino transport in supernovae.
    Keywords: ASTROPHYSICS
    Type: Astrophysics and Space Science; 35; June 197
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  • 95
    Publication Date: 2011-08-16
    Description: Data from the all-sky X-ray monitor aboard Ariel V were used to establish that a sudden transition had occurred in emissions from Cyg X-1 on April 22, 1975. Cyg X-1 has been observed almost continuously since around November 1, 1974, and has been relatively constant in apparent magnitude until the reported effect. The results of these observations are discussed.
    Keywords: ASTROPHYSICS
    Type: Nature; 256; July 10
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  • 96
    Publication Date: 2011-08-16
    Description: The equipment, method and results of the measurements performed with soft and hard X-ray detectors of the Space Research Laboratory in Utrecht and the Center for Astrophysics in Cambridge, Mass., are described. Cyg X-1 underwent an upward transition in its intensity, that seems to be the inverse of the downward transition seen by Uhuru in April 1971. The bulk of the increase, as observed by the Astronomical Netherlands Satellite instruments, from May 1 to May 8, 1975, occurs at low energy: between 1 and 2 keV, the intensity increased by a factor of 10 over the November 1974 intensity, while above 8 keV there is no significant change. The data suggest that Cyg X-1 has reverted to its high state.
    Keywords: ASTROPHYSICS
    Type: Nature; 256; July 10
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  • 97
    Publication Date: 2011-08-16
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 198; June 15
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  • 98
    Publication Date: 2011-08-16
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 198; June 15
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  • 99
    Publication Date: 2011-08-16
    Description: High-resolution 21-cm hydrogen line observations at low galactic latitude are analyzed to determine the large-scale distribution of galactic hydrogen. Distribution parameters are found by model fitting, optical depth effects are computed using a two-component gas model suggested by the observations, and calculations are made for a one-component uniform spin-temperature gas model to show the systematic departures between this model and data obtained by incorrect treatment of the optical depth effects. Synthetic 21-cm line profiles are computed from the two-component model, and the large-scale trends of the observed emission profiles are reproduced together with the magnitude of the small-scale emission irregularities. Values are determined for the thickness of the galactic hydrogen disk between half density points, the total observed neutral hydrogen mass of the galaxy, and the central number density of the intercloud hydrogen atoms. It is shown that typical hydrogen clouds must be between 1 and 13 pc in diameter and that optical thinness exists on large-scale despite the presence of optically thin gas.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal; 198; June 1
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  • 100
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    Publication Date: 2011-08-16
    Description: The properties of cometary dust-swarms in almost parabolic long-period orbits are examined. The effect of passage of the solar system through interstellar gas clouds is shown to be capable of affecting substantially the angular momentum of a comet about the sun, thus accounting for the existence of comets with high values of perihelion distance. The same process would enable cometary particles to adsorb interstellar gases and regenerate their gas content.
    Keywords: ASTROPHYSICS
    Type: Astrophysics and Space Science; 34; May 1975
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