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  • History, 20th Century  (177)
  • Models, Biological  (119)
  • History, Ancient  (96)
  • Nature Publishing Group (NPG)  (373)
  • Irkutsk : Ross. Akad. Nauk, Sibirskoe Otd., Inst. Zemnoj Kory
  • Krefeld : Geologischer Dienst Nordhein-Westfalen
  • 2005-2009  (373)
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  • 1
    Publication Date: 2009-12-23
    Description: Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2-3 weeks), the frequency is low (〈0.1%), and DNA demethylation constitutes a bottleneck. To determine regulatory mechanisms involved in reprogramming, we generated interspecies heterokaryons (fused mouse embryonic stem (ES) cells and human fibroblasts) that induce reprogramming synchronously, frequently and fast. Here we show that reprogramming towards pluripotency in single heterokaryons is initiated without cell division or DNA replication, rapidly (1 day) and efficiently (70%). Short interfering RNA (siRNA)-mediated knockdown showed that activation-induced cytidine deaminase (AID, also known as AICDA) is required for promoter demethylation and induction of OCT4 (also known as POU5F1) and NANOG gene expression. AID protein bound silent methylated OCT4 and NANOG promoters in fibroblasts, but not active demethylated promoters in ES cells. These data provide new evidence that mammalian AID is required for active DNA demethylation and initiation of nuclear reprogramming towards pluripotency in human somatic cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906123/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906123/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhutani, Nidhi -- Brady, Jennifer J -- Damian, Mara -- Sacco, Alessandra -- Corbel, Stephane Y -- Blau, Helen M -- AG009521/AG/NIA NIH HHS/ -- AG024987/AG/NIA NIH HHS/ -- AI007328/AI/NIAID NIH HHS/ -- R01 AG009521/AG/NIA NIH HHS/ -- R01 AG009521-25/AG/NIA NIH HHS/ -- R01 AG024987/AG/NIA NIH HHS/ -- R01 AG024987-05/AG/NIA NIH HHS/ -- T32 AI007328/AI/NIAID NIH HHS/ -- U01 HL100397/HL/NHLBI NIH HHS/ -- England -- Nature. 2010 Feb 25;463(7284):1042-7. doi: 10.1038/nature08752.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5175, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20027182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Fusion ; Cell Line ; Cells, Cultured ; Cellular Reprogramming/genetics/*physiology ; Chromatin Immunoprecipitation ; Cytidine Deaminase/deficiency/genetics/*metabolism ; DNA/chemistry/genetics/metabolism ; *DNA Methylation ; DNA Replication ; Embryonic Stem Cells/cytology/metabolism ; Fibroblasts/cytology/metabolism ; Gene Expression Regulation ; Gene Knockdown Techniques ; Homeodomain Proteins/genetics ; Humans ; Induced Pluripotent Stem Cells/*cytology/enzymology/*metabolism ; Lung/cytology/embryology ; Mice ; Models, Biological ; Octamer Transcription Factor-3/genetics ; Promoter Regions, Genetic/genetics ; Time Factors
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    Electronic ISSN: 1476-4687
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  • 2
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    Nature Publishing Group (NPG)
    Publication Date: 2009-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalton, Rex -- England -- Nature. 2009 Jan 15;457(7227):241. doi: 10.1038/457241a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19148062" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Energy Resources/*trends ; History, 20th Century ; History, 21st Century ; United States ; United States Government Agencies/*organization & administration
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    Nature Publishing Group (NPG)
    Publication Date: 2009-09-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goode, Scott -- England -- Nature. 2009 Sep 10;461(7261):167. doi: 10.1038/461167d.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19741681" target="_blank"〉PubMed〈/a〉
    Keywords: History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; *Religion and Science ; Research Personnel/*history/psychology/standards
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
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    Nature Publishing Group (NPG)
    Publication Date: 2009-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalton, Rex -- Witze, Alexandra -- England -- Nature. 2009 Mar 26;458(7237):396. doi: 10.1038/458396a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19334300" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ecosystem ; *Greenhouse Effect ; History, 20th Century ; History, 21st Century ; Leadership ; Marine Biology ; United States ; United States Government Agencies/*organization & administration
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sunami, Atsushi -- Kurokawa, Kiyoshi -- England -- Nature. 2009 Feb 19;457(7232):960-1. doi: 10.1038/457960a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Graduate Institute for Policy Studies in Tokyo. sunami-atsushi@grips.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225502" target="_blank"〉PubMed〈/a〉
    Keywords: Emigrants and Immigrants ; Financing, Government/history ; Foreign Professional Personnel ; History, 20th Century ; History, 21st Century ; International Cooperation ; Japan ; *Public Policy ; Research/economics/*history/manpower/*trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2009-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kayani, Saheeb Ahmed -- England -- Nature. 2009 Dec 24;462(7276):984. doi: 10.1038/462984b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20033020" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; History, 20th Century ; History, 21st Century ; Humans ; Pakistan ; *Religion and Science ; Science/history
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
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    Nature Publishing Group (NPG)
    Publication Date: 2009-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reiff, Sarah B -- Striepen, Boris -- England -- Nature. 2009 Jun 18;459(7249):918-9. doi: 10.1038/459918a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19536248" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Malaria, Falciparum/drug therapy/*parasitology ; Models, Biological ; Plasmodium falciparum/*metabolism ; Protein Binding ; Protein Transport ; Protozoan Proteins/antagonists & inhibitors/*metabolism ; Vacuoles/metabolism/parasitology
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  • 8
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    Nature Publishing Group (NPG)
    Publication Date: 2009-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swaminathan, M S -- England -- Nature. 2009 Oct 15;461(7266):894. doi: 10.1038/461894a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉M. S. Swaminathan Research Foundation, Third Cross Street, Taramani Institutional Area, Chennai 600 113, India. chairman@mssrf.res.in〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19829366" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*history ; Breeding/history ; Food Supply/history ; History, 20th Century ; History, 21st Century ; Humans ; Plant Diseases/genetics/microbiology ; Triticum/genetics/physiology
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2009-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonnell, Anna -- England -- Nature. 2009 Jun 18;459(7249):909. doi: 10.1038/459909b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19536241" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Fertility ; History, Ancient ; Humans ; Pregnancy ; Sculpture/*history
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  • 10
    Publication Date: 2009-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rensberger, Boyce -- England -- Nature. 2009 Jun 25;459(7250):1055-6. doi: 10.1038/4591055a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Knight Science Journalism Fellowship programme at the Massachusetts Institute of Technology in Cambridge. boycerensberger@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19553977" target="_blank"〉PubMed〈/a〉
    Keywords: History, 19th Century ; History, 20th Century ; History, 21st Century ; Journalism/history/standards/*trends ; Periodicals as Topic ; *Science
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    Electronic ISSN: 1476-4687
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  • 11
    Publication Date: 2009-02-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goudsmit, Jaap -- England -- Nature. 2009 Jan 22;457(7228):394. doi: 10.1038/457394a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jaap Goudsmit is in the Research and Development Department of Crucell Holland, PO Box 2048, Leiden, 2301 CA, the Netherlands, and in the Academic Medical Center of the University of Amsterdam. j.goudsmit@crucell.com.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19158783" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; History, 20th Century ; History, 21st Century ; Humans ; Nobel Prize ; Prion Diseases/*history/transmission ; Prions/chemistry/*history/metabolism
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  • 12
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    Nature Publishing Group (NPG)
    Publication Date: 2009-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gowans, James -- England -- Nature. 2009 May 28;459(7246):506. doi: 10.1038/459506c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478763" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic/history ; Correspondence as Topic/history ; Female ; Great Britain ; History, 20th Century ; Humans ; Periodicals as Topic/*history
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  • 13
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    Nature Publishing Group (NPG)
    Publication Date: 2009-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2009 Mar 26;458(7237):385. doi: 10.1038/458386a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325578" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; *Genes ; *Genetic Testing/economics/legislation & jurisprudence ; History, 20th Century ; History, 21st Century ; Humans ; Patents as Topic/history/*legislation & jurisprudence/*statistics & numerical ; data ; United States
    Print ISSN: 0028-0836
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  • 14
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    Nature Publishing Group (NPG)
    Publication Date: 2009-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kell, Douglas -- England -- Nature. 2009 Apr 16;458(7240):831. doi: 10.1038/458831b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19370012" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; History, 21st Century ; Microbiological Techniques/*history ; Microbiology/*history
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  • 15
    Publication Date: 2009-07-10
    Description: The modern Arctic Ocean is regarded as a barometer of global change and amplifier of global warming and therefore records of past Arctic change are critical for palaeoclimate reconstruction. Little is known of the state of the Arctic Ocean in the greenhouse period of the Late Cretaceous epoch (65-99 million years ago), yet records from such times may yield important clues to Arctic Ocean behaviour in near-future warmer climates. Here we present a seasonally resolved Cretaceous sedimentary record from the Alpha ridge of the Arctic Ocean. This palaeo-sediment trap provides new insight into the workings of the Cretaceous marine biological carbon pump. Seasonal primary production was dominated by diatom algae but was not related to upwelling as was previously hypothesized. Rather, production occurred within a stratified water column, involving specially adapted species in blooms resembling those of the modern North Pacific subtropical gyre, or those indicated for the Mediterranean sapropels. With increased CO(2) levels and warming currently driving increased stratification in the global ocean, this style of production that is adapted to stratification may become more widespread. Our evidence for seasonal diatom production and flux testify to an ice-free summer, but thin accumulations of terrigenous sediment within the diatom ooze are consistent with the presence of intermittent sea ice in the winter, supporting a wide body of evidence for low temperatures in the Late Cretaceous Arctic Ocean, rather than recent suggestions of a 15 degrees C mean annual temperature at this time.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, Andrew -- Kemp, Alan E S -- Pike, Jennifer -- England -- Nature. 2009 Jul 9;460(7252):254-8. doi: 10.1038/nature08141.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Oceanography Centre Southampton, School of Ocean and Earth Science, University of Southampton, Southampton, SO14 3ZH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19587768" target="_blank"〉PubMed〈/a〉
    Keywords: Arctic Regions ; Carbon Dioxide/metabolism ; Diatoms/metabolism ; Fossils ; Geologic Sediments/analysis/microbiology ; *Greenhouse Effect ; History, Ancient ; Ice Cover/chemistry ; Marine Biology ; Oceans and Seas ; *Seasons ; *Seawater ; *Temperature
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  • 16
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    Nature Publishing Group (NPG)
    Publication Date: 2009-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, David -- England -- Nature. 2009 May 14;459(7244):163. doi: 10.1038/459163a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19444189" target="_blank"〉PubMed〈/a〉
    Keywords: *Editorial Policies ; History, 20th Century ; Periodicals as Topic/*history
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  • 17
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    Nature Publishing Group (NPG)
    Publication Date: 2009-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellars, Paul -- England -- Nature. 2009 May 14;459(7244):176-7. doi: 10.1038/459176a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19444200" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; Female ; Germany ; History, Ancient ; Horns/chemistry ; Humans ; Sculpture/*history ; Sex Characteristics ; Symbolism
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  • 18
    Publication Date: 2009-12-18
    Description: An important challenge in systems biology is to quantitatively describe microbial growth using a few measurable parameters that capture the essence of this complex phenomenon. Two key events at the cell membrane-extracellular glucose sensing and uptake-initiate the budding yeast's growth on glucose. However, conventional growth models focus almost exclusively on glucose uptake. Here we present results from growth-rate experiments that cannot be explained by focusing on glucose uptake alone. By imposing a glucose uptake rate independent of the sensed extracellular glucose level, we show that despite increasing both the sensed glucose concentration and uptake rate, the cell's growth rate can decrease or even approach zero. We resolve this puzzle by showing that the interaction between glucose perception and import, not their individual actions, determines the central features of growth, and characterize this interaction using a quantitative model. Disrupting this interaction by knocking out two key glucose sensors significantly changes the cell's growth rate, yet uptake rates are unchanged. This is due to a decrease in burden that glucose perception places on the cells. Our work shows that glucose perception and import are separate and pivotal modules of yeast growth, the interaction of which can be precisely tuned and measured.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796206/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796206/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Youk, Hyun -- van Oudenaarden, Alexander -- DP1 OD003936/OD/NIH HHS/ -- DP1 OD003936-01/OD/NIH HHS/ -- DP1 OD003936-02/OD/NIH HHS/ -- R01 GM068957/GM/NIGMS NIH HHS/ -- R01 GM068957-06/GM/NIGMS NIH HHS/ -- R01 GM068957-07/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Dec 17;462(7275):875-9. doi: 10.1038/nature08653.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20016593" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport/drug effects ; Cell Growth Processes/drug effects ; Cell Membrane/drug effects/metabolism ; Doxycycline/pharmacology ; Glucose/*metabolism/pharmacology ; Kinetics ; Models, Biological ; Saccharomyces cerevisiae/cytology/drug effects/*growth & development/*metabolism
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  • 19
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    Nature Publishing Group (NPG)
    Publication Date: 2009-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gratzer, Walter -- England -- Nature. 2009 Apr 23;458(7241):983-4. doi: 10.1038/458983a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19396135" target="_blank"〉PubMed〈/a〉
    Keywords: *Editorial Policies ; Great Britain ; History, 20th Century ; Periodicals as Topic/*history ; Physics/history ; Science/*history
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  • 20
    Publication Date: 2009-04-28
    Description: Plant photosynthesis tends to increase with irradiance. However, recent theoretical and observational studies have demonstrated that photosynthesis is also more efficient under diffuse light conditions. Changes in cloud cover or atmospheric aerosol loadings, arising from either volcanic or anthropogenic emissions, alter both the total photosynthetically active radiation reaching the surface and the fraction of this radiation that is diffuse, with uncertain overall effects on global plant productivity and the land carbon sink. Here we estimate the impact of variations in diffuse fraction on the land carbon sink using a global model modified to account for the effects of variations in both direct and diffuse radiation on canopy photosynthesis. We estimate that variations in diffuse fraction, associated largely with the 'global dimming' period, enhanced the land carbon sink by approximately one-quarter between 1960 and 1999. However, under a climate mitigation scenario for the twenty-first century in which sulphate aerosols decline before atmospheric CO(2) is stabilized, this 'diffuse-radiation' fertilization effect declines rapidly to near zero by the end of the twenty-first century.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercado, Lina M -- Bellouin, Nicolas -- Sitch, Stephen -- Boucher, Olivier -- Huntingford, Chris -- Wild, Martin -- Cox, Peter M -- England -- Nature. 2009 Apr 23;458(7241):1014-7. doi: 10.1038/nature07949.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Ecology and Hydrology, Wallingford OX10 8BB, UK. lmme@ceh.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19396143" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols/analysis/chemistry ; Atmosphere/*chemistry ; Carbon/*metabolism ; Carbon Dioxide/analysis ; *Darkness ; *Ecosystem ; Greenhouse Effect ; History, 20th Century ; History, 21st Century ; Photosynthesis/*radiation effects ; Plants/metabolism/*radiation effects ; Sulfates/metabolism ; *Sunlight ; Volcanic Eruptions
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  • 21
    Publication Date: 2009-09-11
    Description: It is widely accepted that tissue differentiation and morphogenesis in multicellular organisms are regulated by tightly controlled concentration gradients of morphogens. How exactly these gradients are formed, however, remains unclear. Here we show that Fgf8 morphogen gradients in living zebrafish embryos are established and maintained by two essential factors: fast, free diffusion of single molecules away from the source through extracellular space, and a sink function of the receiving cells, regulated by receptor-mediated endocytosis. Evidence is provided by directly examining single molecules of Fgf8 in living tissue by fluorescence correlation spectroscopy, quantifying their local mobility and concentration with high precision. By changing the degree of uptake of Fgf8 into its target cells, we are able to alter the shape of the Fgf8 gradient. Our results demonstrate that a freely diffusing morphogen can set up concentration gradients in a complex multicellular tissue by a simple source-sink mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, Shuizi Rachel -- Burkhardt, Markus -- Nowak, Matthias -- Ries, Jonas -- Petrasek, Zdenek -- Scholpp, Steffen -- Schwille, Petra -- Brand, Michael -- England -- Nature. 2009 Sep 24;461(7263):533-6. doi: 10.1038/nature08391. Epub 2009 Sep 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47-49, 01307 Dresden, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19741606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diffusion ; Embryo, Nonmammalian/*cytology/embryology/*metabolism ; *Endocytosis ; Extracellular Space/metabolism ; Fibroblast Growth Factors/genetics/*metabolism ; Gastrulation ; Green Fluorescent Proteins/genetics/metabolism ; Models, Biological ; Morphogenesis/*physiology ; Receptors, Fibroblast Growth Factor/metabolism ; Zebrafish/*embryology/*metabolism ; Zebrafish Proteins/genetics/*metabolism
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  • 22
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    Nature Publishing Group (NPG)
    Publication Date: 2009-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchenau, Jurgen -- England -- Nature. 2009 Nov 19;462(7271):284-5. doi: 10.1038/462284a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of History at the University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, North Carolina 28223, USA. jbuchenau@uncc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19924194" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Emigration and Immigration ; Europe ; History, 19th Century ; History, 20th Century ; Humans ; Latin America ; Public Policy/history/*trends
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  • 23
    Publication Date: 2009-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rockstrom, Johan -- Steffen, Will -- Noone, Kevin -- Persson, Asa -- Chapin, F Stuart 3rd -- Lambin, Eric F -- Lenton, Timothy M -- Scheffer, Marten -- Folke, Carl -- Schellnhuber, Hans Joachim -- Nykvist, Bjorn -- de Wit, Cynthia A -- Hughes, Terry -- van der Leeuw, Sander -- Rodhe, Henning -- Sorlin, Sverker -- Snyder, Peter K -- Costanza, Robert -- Svedin, Uno -- Falkenmark, Malin -- Karlberg, Louise -- Corell, Robert W -- Fabry, Victoria J -- Hansen, James -- Walker, Brian -- Liverman, Diana -- Richardson, Katherine -- Crutzen, Paul -- Foley, Jonathan A -- England -- Nature. 2009 Sep 24;461(7263):472-5. doi: 10.1038/461472a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stockholm Resilience Centre, Stockholm University, Kraftriket 2B, 10691 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19779433" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Civilization ; Conservation of Natural Resources/*methods/trends ; *Earth (Planet) ; Ecology/*methods/*trends ; *Ecosystem ; Extinction, Biological ; Fossils ; Green Chemistry Technology/*methods/trends ; Greenhouse Effect ; History, 20th Century ; History, 21st Century ; History, Ancient ; *Human Activities/history ; Humans ; Nitrogen/metabolism ; Phosphorus/metabolism
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  • 24
    Publication Date: 2009-06-19
    Description: Several hundred malaria parasite proteins are exported beyond an encasing vacuole and into the cytosol of the host erythrocyte, a process that is central to the virulence and viability of the causative Plasmodium species. The trafficking machinery responsible for this export is unknown. Here we identify in Plasmodium falciparum a translocon of exported proteins (PTEX), which is located in the vacuole membrane. The PTEX complex is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a novel protein termed PTEX150 and a known parasite protein, exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, a new protein PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components. As a common portal for numerous crucial processes, this translocon offers a new avenue for therapeutic intervention.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725363/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725363/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Koning-Ward, Tania F -- Gilson, Paul R -- Boddey, Justin A -- Rug, Melanie -- Smith, Brian J -- Papenfuss, Anthony T -- Sanders, Paul R -- Lundie, Rachel J -- Maier, Alexander G -- Cowman, Alan F -- Crabb, Brendan S -- R01 AI044008-11/AI/NIAID NIH HHS/ -- R01 AI44008/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2009 Jun 18;459(7249):945-9. doi: 10.1038/nature08104.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Walter & Eliza Hall Institute of Medical Research, Melbourne 3052, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19536257" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Malaria, Falciparum/*parasitology ; Models, Biological ; Multiprotein Complexes/*chemistry/*metabolism ; Plasmodium falciparum/*metabolism ; Protein Binding ; Protein Transport ; Protozoan Proteins/*metabolism
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  • 25
    Publication Date: 2009-07-17
    Description: In recent years, strikingly consistent patterns of biodiversity have been identified over space, time, organism type and geographical region. A neutral theory (assuming no environmental selection or organismal interactions) has been shown to predict many patterns of ecological biodiversity. This theory is based on a mechanism by which new species arise similarly to point mutations in a population without sexual reproduction. Here we report the simulation of populations with sexual reproduction, mutation and dispersal. We found simulated time dependence of speciation rates, species-area relationships and species abundance distributions consistent with the behaviours found in nature. From our results, we predict steady speciation rates, more species in one-dimensional environments than two-dimensional environments, three scaling regimes of species-area relationships and lognormal distributions of species abundance with an excess of rare species and a tail that may be approximated by Fisher's logarithmic series. These are consistent with dependences reported for, among others, global birds and flowering plants, marine invertebrate fossils, ray-finned fishes, British birds and moths, North American songbirds, mammal fossils from Kansas and Panamanian shrubs. Quantitative comparisons of specific cases are remarkably successful. Our biodiversity results provide additional evidence that species diversity arises without specific physical barriers. This is similar to heavy traffic flows, where traffic jams can form even without accidents or barriers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Aguiar, M A M -- Baranger, M -- Baptestini, E M -- Kaufman, L -- Bar-Yam, Y -- England -- Nature. 2009 Jul 16;460(7253):384-7. doi: 10.1038/nature08168.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉New England Complex Systems Institute, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19606148" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Disorders of Sex Development ; Extinction, Biological ; *Genetic Speciation ; Genotype ; Haploidy ; Models, Biological ; Mutation/genetics ; Population Dynamics ; Reproduction/genetics/*physiology ; Sexual Behavior, Animal ; Time Factors
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  • 26
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    Nature Publishing Group (NPG)
    Publication Date: 2009-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zahn, Rainer -- England -- Nature. 2009 Jul 16;460(7253):335-6. doi: 10.1038/460335a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institucio Catalana de Recerca i Estudis Avancats (ICREA), Institut de Ciencia i Tecnologia Ambientals and Departmento de Geologia, Universitat Autonoma de Barcelona, Bellaterra E-08193, Spain. rainer.zahn@uab.cat.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19606136" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; Atlantic Ocean ; Atmosphere/chemistry ; Carbon Dioxide/metabolism ; *Climate ; Geologic Sediments/microbiology ; History, Ancient ; Ice Cover ; Indian Ocean ; Seawater/chemistry ; *Temperature ; *Water Movements
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  • 27
    Publication Date: 2009-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burnap, Don -- England -- Nature. 2009 Jan 29;457(7229):533. doi: 10.1038/457533b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19177110" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Enhancement/history ; Cannabinoids/*history ; *Cognition ; Creativity ; Hallucinogens/*history ; Health ; History, 20th Century ; History, 21st Century ; Humans ; Lysergic Acid Diethylamide/*history
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  • 28
    Publication Date: 2009-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Demain, Arnold L -- England -- Nature. 2009 Feb 26;457(7233):1079. doi: 10.1038/4571079c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19242451" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*history ; Congresses as Topic/history ; Cuba ; History, 20th Century ; *International Cooperation ; Politics ; Research Personnel/*history ; United States
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  • 29
    Publication Date: 2009-05-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rothschild, Lynn J -- England -- Nature. 2009 May 21;459(7245):335-6. doi: 10.1038/459335a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19458704" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; *Earth (Planet) ; History, Ancient ; Hot Temperature ; *Meteoroids ; *Models, Biological ; Moon ; *Origin of Life ; Silicates/analysis ; Sterilization ; Time Factors ; Zirconium/analysis
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  • 30
    Publication Date: 2009-02-06
    Description: The Atlantic meridional overturning circulation (AMOC) transports warm salty surface waters to high latitudes, where they cool, sink and return southwards at depth. Through its attendant meridional heat transport, the AMOC helps maintain a warm northwestern European climate, and acts as a control on the global climate. Past climate fluctuations during the Holocene epoch ( approximately 11,700 years ago to the present) have been linked with changes in North Atlantic Ocean circulation. The behaviour of the surface flowing salty water that helped drive overturning during past climatic changes is, however, not well known. Here we investigate the temperature and salinity changes of a substantial surface inflow to a region of deep-water formation throughout the Holocene. We find that the inflow has undergone millennial-scale variations in temperature and salinity ( approximately 3.5 degrees C and approximately 1.5 practical salinity units, respectively) most probably controlled by subpolar gyre dynamics. The temperature and salinity variations correlate with previously reported periods of rapid climate change. The inflow becomes more saline during enhanced freshwater flux to the subpolar North Atlantic. Model studies predict a weakening of AMOC in response to enhanced Arctic freshwater fluxes, although the inflow can compensate on decadal timescales by becoming more saline. Our data suggest that such a negative feedback mechanism may have operated during past intervals of climate change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornalley, David J R -- Elderfield, Harry -- McCave, I Nick -- England -- Nature. 2009 Feb 5;457(7230):711-4. doi: 10.1038/nature07717.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Godwin Laboratory for Palaeoclimate Research, Department of Earth Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EQ, UK. d.thornalley@cantab.net〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19194447" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Calcium Carbonate/analysis ; Climate ; Feedback ; Fresh Water/analysis/chemistry ; History, Ancient ; Oxygen Isotopes ; Plankton/metabolism ; *Salinity ; Seawater/*chemistry ; *Temperature ; *Water Movements
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  • 31
    Publication Date: 2009-07-10
    Description: Many aspects of the carbon cycle can be assessed from temporal changes in the (13)C/(12)C ratio of oceanic bicarbonate. (13)C/(12)C can temporarily rise when large amounts of (13)C-depleted photosynthetic organic matter are buried at enhanced rates, and can decrease if phytomass is rapidly oxidized or if low (13)C is rapidly released from methane clathrates. Assuming that variations of the marine (13)C/(12)C ratio are directly recorded in carbonate rocks, thousands of carbon isotope analyses of late Precambrian examples have been published to correlate these otherwise undatable strata and to document perturbations to the carbon cycle just before the great expansion of metazoan life. Low (13)C/(12)C in some Neoproterozoic carbonates is considered evidence of carbon cycle perturbations unique to the Precambrian. These include complete oxidation of all organic matter in the ocean and complete productivity collapse such that low-(13)C/(12)C hydrothermal CO(2) becomes the main input of carbon. Here we compile all published oxygen and carbon isotope data for Neoproterozoic marine carbonates, and consider them in terms of processes known to alter the isotopic composition during transformation of the initial precipitate into limestone/dolostone. We show that the combined oxygen and carbon isotope systematics are identical to those of well-understood Phanerozoic examples that lithified in coastal pore fluids, receiving a large groundwater influx of photosynthetic carbon from terrestrial phytomass. Rather than being perturbations to the carbon cycle, widely reported decreases in (13)C/(12)C in Neoproterozoic carbonates are more easily interpreted in the same way as is done for Phanerozoic examples. This influx of terrestrial carbon is not apparent in carbonates older than approximately 850 Myr, so we infer an explosion of photosynthesizing communities on late Precambrian land surfaces. As a result, biotically enhanced weathering generated carbon-bearing soils on a large scale and their detrital sedimentation sequestered carbon. This facilitated a rise in O(2) necessary for the expansion of multicellular life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knauth, L Paul -- Kennedy, Martin J -- England -- Nature. 2009 Aug 6;460(7256):728-32. doi: 10.1038/nature08213. Epub 2009 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Earth and Space Exploration, Arizona State University, Tempe, Arizona 85287-1404, USA. Knauth@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19587681" target="_blank"〉PubMed〈/a〉
    Keywords: Biomass ; Calcium Carbonate/chemistry ; Carbon/chemistry/*metabolism ; Carbon Isotopes ; Carbonates/*analysis/*chemistry ; Earth (Planet) ; Geologic Sediments/*chemistry ; History, Ancient ; Magnesium/chemistry ; Oceans and Seas ; Oxygen/analysis/metabolism ; Oxygen Isotopes ; *Photosynthesis ; Plants/metabolism
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  • 32
    Publication Date: 2009-01-17
    Description: Autonomous and self-sustained oscillator circuits mediating the periodic induction of specific target genes are minimal genetic time-keeping devices found in the central and peripheral circadian clocks. They have attracted significant attention because of their intriguing dynamics and their importance in controlling critical repair, metabolic and signalling pathways. The precise molecular mechanism and expression dynamics of this mammalian circadian clock are still not fully understood. Here we describe a synthetic mammalian oscillator based on an auto-regulated sense-antisense transcription control circuit encoding a positive and a time-delayed negative feedback loop, enabling autonomous, self-sustained and tunable oscillatory gene expression. After detailed systems design with experimental analyses and mathematical modelling, we monitored oscillating concentrations of green fluorescent protein with tunable frequency and amplitude by time-lapse microscopy in real time in individual Chinese hamster ovary cells. The synthetic mammalian clock may provide an insight into the dynamics of natural periodic processes and foster advances in the design of prosthetic networks in future gene and cell therapies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tigges, Marcel -- Marquez-Lago, Tatiana T -- Stelling, Jorg -- Fussenegger, Martin -- England -- Nature. 2009 Jan 15;457(7227):309-12. doi: 10.1038/nature07616.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19148099" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks/*physiology ; CHO Cells ; Circadian Rhythm/*physiology ; Cricetinae ; Cricetulus ; Feedback, Physiological ; Fluorescence ; Gene Expression Regulation/*genetics ; Genes, Synthetic/*genetics ; *Genetic Engineering ; Green Fluorescent Proteins/analysis/genetics/metabolism ; Models, Biological ; Reproducibility of Results ; Time Factors ; Transcription, Genetic
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  • 33
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhdanov, Renad -- England -- Nature. 2009 Feb 19;457(7232):956. doi: 10.1038/457956a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225497" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Research Personnel/*history ; Science/*history ; Turkey ; Universities/trends
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  • 34
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    Nature Publishing Group (NPG)
    Publication Date: 2009-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monastersky, Richard -- England -- Nature. 2009 Jul 16;460(7253):314-5. doi: 10.1038/460314a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19606113" target="_blank"〉PubMed〈/a〉
    Keywords: Astronauts/economics/*history/*trends ; Europe ; History, 20th Century ; History, 21st Century ; *Moon ; Research Personnel/psychology ; Space Flight/economics/*history/*trends ; United States ; United States National Aeronautics and Space ; Administration/economics/*history/*trends
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  • 35
    Publication Date: 2009-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gurney, Kevin Robert -- England -- Nature. 2009 Apr 23;458(7241):977-9. doi: 10.1038/458977a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19396132" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/chemistry ; Carbon/analysis/*metabolism ; Carbon Dioxide/analysis/chemistry/metabolism ; China ; *Ecosystem ; *Fossil Fuels ; History, 20th Century ; History, 21st Century ; Soil/analysis ; Trees/metabolism ; United States
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  • 36
    Publication Date: 2009-03-20
    Description: Ornithischia is one of the two major groups of dinosaurs, with heterodontosauridae as one of its major clades. Heterodontosauridae is characterized by small, gracile bodies and a problematic phylogenetic position. Recent phylogenetic work indicates that it represents the most basal group of all well-known ornithischians. Previous heterodontosaurid records are mainly from the Early Jurassic period (205-190 million years ago) of Africa. Here we report a new heterodontosaurid, Tianyulong confuciusi gen. et sp. nov., from the Early Cretaceous period (144-99 million years ago) of western Liaoning Province, China. Tianyulong extends the geographical distribution of heterodontosaurids to Asia and confirms the clade's previously questionable temporal range extension into the Early Cretaceous period. More surprisingly, Tianyulong bears long, singular and unbranched filamentous integumentary (outer skin) structures. This represents the first confirmed report, to our knowledge, of filamentous integumentary structures in an ornithischian dinosaur.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zheng, Xiao-Ting -- You, Hai-Lu -- Xu, Xing -- Dong, Zhi-Ming -- England -- Nature. 2009 Mar 19;458(7236):333-6. doi: 10.1038/nature07856.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Shandong Tianyu Museum of Nature, Lianhuashan Road West, Pingyi, Shandong, 273300, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19295609" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; China ; Dentition ; Dinosaurs/*anatomy & histology/*classification ; Feathers/anatomy & histology ; Fossils ; History, Ancient ; Integumentary System/*anatomy & histology ; Phylogeny ; Skin/anatomy & histology ; Skull/anatomy & histology
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  • 37
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    Nature Publishing Group (NPG)
    Publication Date: 2009-11-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Todes, Daniel -- England -- Nature. 2009 Nov 5;462(7269):36-7. doi: 10.1038/462036a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of the History of Medicine at Johns Hopkins University, 1900 East Monument Street, Baltimore, Maryland 21205, USA. dtodes@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19890312" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Biological Science Disciplines/*history ; *Competitive Behavior ; Cooperative Behavior ; *Cultural Diversity ; Food Supply ; Great Britain ; History, 19th Century ; History, 20th Century ; Humans ; Literature, Modern/history ; Metaphor ; Models, Biological ; Population Density ; Russia ; Selection, Genetic
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  • 38
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    Nature Publishing Group (NPG)
    Publication Date: 2009-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England -- Nature. 2009 Jan 8;457(7226):129-30. doi: 10.1038/457129b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19129800" target="_blank"〉PubMed〈/a〉
    Keywords: *Conflict (Psychology) ; *Cultural Diversity ; History, 20th Century ; History, 21st Century ; Social Sciences/*history ; United States ; Violence ; Warfare
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  • 39
    Publication Date: 2009-12-18
    Description: With polar temperatures approximately 3-5 degrees C warmer than today, the last interglacial stage (approximately 125 kyr ago) serves as a partial analogue for 1-2 degrees C global warming scenarios. Geological records from several sites indicate that local sea levels during the last interglacial were higher than today, but because local sea levels differ from global sea level, accurately reconstructing past global sea level requires an integrated analysis of globally distributed data sets. Here we present an extensive compilation of local sea level indicators and a statistical approach for estimating global sea level, local sea levels, ice sheet volumes and their associated uncertainties. We find a 95% probability that global sea level peaked at least 6.6 m higher than today during the last interglacial; it is likely (67% probability) to have exceeded 8.0 m but is unlikely (33% probability) to have exceeded 9.4 m. When global sea level was close to its current level (〉or=-10 m), the millennial average rate of global sea level rise is very likely to have exceeded 5.6 m kyr(-1) but is unlikely to have exceeded 9.2 m kyr(-1). Our analysis extends previous last interglacial sea level studies by integrating literature observations within a probabilistic framework that accounts for the physics of sea level change. The results highlight the long-term vulnerability of ice sheets to even relatively low levels of sustained global warming.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kopp, Robert E -- Simons, Frederik J -- Mitrovica, Jerry X -- Maloof, Adam C -- Oppenheimer, Michael -- England -- Nature. 2009 Dec 17;462(7275):863-7. doi: 10.1038/nature08686.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geosciences, Princeton University, Princeton, New Jersey 08544, USA. rkopp@alumni.caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20016591" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Antarctic Regions ; Global Warming/*statistics & numerical data ; Greenhouse Effect ; Greenland ; History, 21st Century ; History, Ancient ; *Ice Cover ; Models, Theoretical ; Oceans and Seas ; *Probability ; Seawater/*analysis ; *Temperature ; Time Factors ; Uncertainty
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  • 40
    Publication Date: 2009-04-17
    Description: During cell division microtubules capture chromosomes by binding to the kinetochore assembled in the centromeric region of chromosomes. In mitosis sister chromatids are captured by microtubules emanating from both spindle poles, a process called bipolar attachment, whereas in meiosis I sisters are attached to microtubules originating from one spindle pole, called monopolar attachment. For determining chromosome orientation, kinetochore geometry or structure might be an important target of regulation. However, the molecular basis of this regulation has remained elusive. Here we show the link between kinetochore orientation and cohesion within the centromere in fission yeast Schizosaccharomyces pombe by strategies developed to visualize the concealed cohesion within the centromere, and to introduce artificial tethers that can influence kinetochore geometry. Our data imply that cohesion at the core centromere induces the mono-orientation of kinetochores whereas cohesion at the peri-centromeric region promotes bi-orientation. Our study may reveal a general mechanism for the geometric regulation of kinetochores, which collaborates with previously defined tension-dependent reorientation machinery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sakuno, Takeshi -- Tada, Kenji -- Watanabe, Yoshinori -- England -- Nature. 2009 Apr 16;458(7240):852-8. doi: 10.1038/nature07876.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19370027" target="_blank"〉PubMed〈/a〉
    Keywords: Centromere/genetics/*metabolism ; Chromosome Segregation ; Kinetochores/*metabolism ; Meiosis ; Microtubules/metabolism ; Mitosis ; Models, Biological ; Schizosaccharomyces/*cytology
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  • 41
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    Publication Date: 2009-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dolgin, Elie -- England -- Nature. 2009 Dec 17;462(7275):843-5. doi: 10.1038/462843a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20016572" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Genome, Human/*genetics ; History, 20th Century ; History, 21st Century ; *Human Genome Project/history ; Humans ; Male ; Reproducibility of Results ; Research Design ; *Research Personnel ; Research Subjects
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  • 42
    Publication Date: 2009-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbondanzieri, Elio A -- Zhuang, Xiaowei -- England -- Nature. 2009 Jan 22;457(7228):392-3. doi: 10.1038/457392a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19158782" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/*chemistry/*metabolism ; Bacillus Phages/*enzymology ; DNA, Viral/chemistry/metabolism ; Hydrolysis ; Models, Biological ; Protein Structure, Quaternary ; Protein Subunits/chemistry/metabolism ; Virus Assembly
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  • 43
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    Publication Date: 2009-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hand, Eric -- England -- Nature. 2009 Dec 24;462(7276):978-83. doi: 10.1038/462978a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20033016" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources ; *Global Warming ; History, 20th Century ; History, 21st Century ; Nobel Prize ; *Physics ; Policy Making ; United States
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  • 44
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    Nature Publishing Group (NPG)
    Publication Date: 2009-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbott, Alison -- England -- Nature. 2009 Oct 8;461(7265):706-7. doi: 10.1038/461706a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19812642" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Aging ; DNA-Directed DNA Polymerase/metabolism ; History, 20th Century ; History, 21st Century ; Humans ; *Nobel Prize ; Saccharomyces cerevisiae/genetics ; Telomerase/genetics/*metabolism ; Telomere/genetics/*metabolism ; Tetrahymena thermophila/genetics ; United States
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  • 45
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    Nature Publishing Group (NPG)
    Publication Date: 2009-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Byam Shaw, Nicholas -- England -- Nature. 2009 Apr 23;458(7241):984-5. doi: 10.1038/458984a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19396136" target="_blank"〉PubMed〈/a〉
    Keywords: History, 19th Century ; History, 20th Century ; Literature, Modern/history ; Periodicals as Topic/history ; Publishing/*history
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  • 46
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller-Landau, Helene C -- England -- Nature. 2009 Feb 19;457(7232):969-70. doi: 10.1038/457969a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225510" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Atmosphere/chemistry ; Biomass ; Carbon/analysis/*metabolism ; Carbon Dioxide/analysis/metabolism ; Models, Biological ; Trees/chemistry/growth & development/*metabolism ; *Tropical Climate ; Wilderness
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  • 47
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tollefson, Jeff -- England -- Nature. 2009 Feb 19;457(7232):942-3. doi: 10.1038/457942b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225485" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Engineering ; *Federal Government ; Fishes ; *Greenhouse Effect ; History, 20th Century ; History, 21st Century ; Hobbies/history ; Marine Biology ; Physics ; *Research Personnel ; United States ; United States Government Agencies/*organization & administration ; Wine
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  • 48
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    Nature Publishing Group (NPG)
    Publication Date: 2009-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campbell, Philip -- England -- Nature. 2009 Apr 23;458(7241):985-6. doi: 10.1038/458985a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19396137" target="_blank"〉PubMed〈/a〉
    Keywords: *Editorial Policies ; Greenhouse Effect ; History, 20th Century ; *Peer Review, Research/methods ; Periodicals as Topic/*history
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  • 49
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    Nature Publishing Group (NPG)
    Publication Date: 2009-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuper, Adam -- England -- Nature. 2009 Dec 17;462(7275):862. doi: 10.1038/462862a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, Yale University, New Haven, Connecticut 06520, USA. adam.kuper@googlemail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20016590" target="_blank"〉PubMed〈/a〉
    Keywords: Anthropology/*history ; Brazil ; France ; History, 20th Century ; Humans ; Indians, South American
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  • 50
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    Nature Publishing Group (NPG)
    Publication Date: 2009-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hand, Eric -- England -- Nature. 2009 Jul 9;460(7252):161. doi: 10.1038/460161a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19587733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Carbon/metabolism ; Cell Respiration ; *Earth (Planet) ; *Ecosystem ; Fossils ; History, Ancient ; Oceans and Seas ; Oxygen/analysis/*metabolism ; Photosynthesis ; Plants/*metabolism ; Seawater/chemistry
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  • 51
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    Nature Publishing Group (NPG)
    Publication Date: 2009-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campbell, Philip -- England -- Nature. 2009 Apr 16;458(7240):807. doi: 10.1038/458807a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19378388" target="_blank"〉PubMed〈/a〉
    Keywords: Editorial Policies ; History, 20th Century ; Journalism/*history ; Peer Review, Research ; Periodicals as Topic/*history
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  • 52
    Publication Date: 2009-08-08
    Description: During the twentieth century, the global population has gone through unprecedented increases in economic and social development that coincided with substantial declines in human fertility and population growth rates. The negative association of fertility with economic and social development has therefore become one of the most solidly established and generally accepted empirical regularities in the social sciences. As a result of this close connection between development and fertility decline, more than half of the global population now lives in regions with below-replacement fertility (less than 2.1 children per woman). In many highly developed countries, the trend towards low fertility has also been deemed irreversible. Rapid population ageing, and in some cases the prospect of significant population decline, have therefore become a central socioeconomic concern and policy challenge. Here we show, using new cross-sectional and longitudinal analyses of the total fertility rate and the human development index (HDI), a fundamental change in the well-established negative relationship between fertility and development as the global population entered the twenty-first century. Although development continues to promote fertility decline at low and medium HDI levels, our analyses show that at advanced HDI levels, further development can reverse the declining trend in fertility. The previously negative development-fertility relationship has become J-shaped, with the HDI being positively associated with fertility among highly developed countries. This reversal of fertility decline as a result of continued economic and social development has the potential to slow the rates of population ageing, thereby ameliorating the social and economic problems that have been associated with the emergence and persistence of very low fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Myrskyla, Mikko -- Kohler, Hans-Peter -- Billari, Francesco C -- England -- Nature. 2009 Aug 6;460(7256):741-3. doi: 10.1038/nature08230.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Population Studies Center, University of Pennsylvania, 3718 Locust Walk, Philadelphia, Pennsylvania 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661915" target="_blank"〉PubMed〈/a〉
    Keywords: Age Distribution ; *Birth Rate/trends ; Cross-Sectional Studies ; Developed Countries/economics/*statistics & numerical data ; Education ; Female ; Fertility/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Income ; Life Expectancy ; Longitudinal Studies ; Male ; Maternal Age ; *Population Growth ; Reproductive Behavior/history/*statistics & numerical data ; Technology/history/statistics & numerical data/trends
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  • 53
    Publication Date: 2009-03-20
    Description: Thirty years after oxygen isotope records from microfossils deposited in ocean sediments confirmed the hypothesis that variations in the Earth's orbital geometry control the ice ages, fundamental questions remain over the response of the Antarctic ice sheets to orbital cycles. Furthermore, an understanding of the behaviour of the marine-based West Antarctic ice sheet (WAIS) during the 'warmer-than-present' early-Pliocene epoch ( approximately 5-3 Myr ago) is needed to better constrain the possible range of ice-sheet behaviour in the context of future global warming. Here we present a marine glacial record from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf by the ANDRILL programme and demonstrate well-dated, approximately 40-kyr cyclic variations in ice-sheet extent linked to cycles in insolation influenced by changes in the Earth's axial tilt (obliquity) during the Pliocene. Our data provide direct evidence for orbitally induced oscillations in the WAIS, which periodically collapsed, resulting in a switch from grounded ice, or ice shelves, to open waters in the Ross embayment when planetary temperatures were up to approximately 3 degrees C warmer than today and atmospheric CO(2) concentration was as high as approximately 400 p.p.m.v. (refs 5, 6). The evidence is consistent with a new ice-sheet/ice-shelf model that simulates fluctuations in Antarctic ice volume of up to +7 m in equivalent sea level associated with the loss of the WAIS and up to +3 m in equivalent sea level from the East Antarctic ice sheet, in response to ocean-induced melting paced by obliquity. During interglacial times, diatomaceous sediments indicate high surface-water productivity, minimal summer sea ice and air temperatures above freezing, suggesting an additional influence of surface melt under conditions of elevated CO(2).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naish, T -- Powell, R -- Levy, R -- Wilson, G -- Scherer, R -- Talarico, F -- Krissek, L -- Niessen, F -- Pompilio, M -- Wilson, T -- Carter, L -- DeConto, R -- Huybers, P -- McKay, R -- Pollard, D -- Ross, J -- Winter, D -- Barrett, P -- Browne, G -- Cody, R -- Cowan, E -- Crampton, J -- Dunbar, G -- Dunbar, N -- Florindo, F -- Gebhardt, C -- Graham, I -- Hannah, M -- Hansaraj, D -- Harwood, D -- Helling, D -- Henrys, S -- Hinnov, L -- Kuhn, G -- Kyle, P -- Laufer, A -- Maffioli, P -- Magens, D -- Mandernack, K -- McIntosh, W -- Millan, C -- Morin, R -- Ohneiser, C -- Paulsen, T -- Persico, D -- Raine, I -- Reed, J -- Riesselman, C -- Sagnotti, L -- Schmitt, D -- Sjunneskog, C -- Strong, P -- Taviani, M -- Vogel, S -- Wilch, T -- Williams, T -- England -- Nature. 2009 Mar 19;458(7236):322-8. doi: 10.1038/nature07867.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Antarctic Research Centre, Victoria University of Wellington, Kelburn Parade, PO Box 600, Wellington 6012, New Zealand. tim.naish@vuw.ac.nz〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19295607" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; Atmosphere/analysis/chemistry ; Calibration ; Carbon Dioxide/analysis ; Diatoms/chemistry/isolation & purification ; Fossils ; History, Ancient ; *Ice Cover ; Oxygen Isotopes ; Temperature
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  • 54
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    Nature Publishing Group (NPG)
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tonzani, Stefano -- England -- Nature. 2009 Feb 19;457(7232):974. doi: 10.1038/457974a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225516" target="_blank"〉PubMed〈/a〉
    Keywords: Colloids/*chemistry ; *Magnetics ; Models, Biological ; Nanostructures/chemistry/ultrastructure ; Particle Size ; Water/chemistry
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  • 55
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    Nature Publishing Group (NPG)
    Publication Date: 2009-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hand, Eric -- England -- Nature. 2009 May 28;459(7246):495. doi: 10.1038/459495a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478752" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; History, 21st Century ; United States ; United States National Aeronautics and Space Administration/*organization & ; administration
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  • 56
    Publication Date: 2009-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kutschera, U -- England -- Nature. 2009 Apr 23;458(7241):967. doi: 10.1038/458967c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19396120" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Competitive Behavior ; Cooperative Behavior ; History, 19th Century ; Models, Biological ; *Selection, Genetic ; *Translating ; *Translations
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    Publication Date: 2009-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abbott, Alison -- England -- Nature. 2009 Apr 2;458(7238):564-7. doi: 10.1038/458564a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19340056" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics/trends ; Anniversaries and Special Events ; History, 20th Century ; History, 21st Century ; Italy ; Nerve Growth Factor/*history ; *Nobel Prize ; Silver Staining/history ; United States ; Women's Rights/history/trends
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    Publication Date: 2009-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eggleston, Angela K -- England -- Nature. 2009 Jan 22;457(7228):395. doi: 10.1038/457395a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19158784" target="_blank"〉PubMed〈/a〉
    Keywords: Gene Knockdown Techniques/history ; History, 20th Century ; History, 21st Century ; Humans ; MicroRNAs/genetics/metabolism ; Nobel Prize ; *RNA Interference
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    Nature Publishing Group (NPG)
    Publication Date: 2009-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nayar, Anjali -- England -- Nature. 2009 Dec 10;462(7274):717-9. doi: 10.1038/462717a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20010663" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cameroon/epidemiology ; Communicable Diseases, Emerging/epidemiology/prevention & ; control/*transmission/*virology ; Disease Outbreaks/prevention & control/veterinary ; History, 20th Century ; History, 21st Century ; Humans ; Population Surveillance/*methods ; Zoonoses/epidemiology/*transmission/*virology
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  • 60
    Publication Date: 2009-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abler, William L -- England -- Nature. 2009 Jan 22;457(7228):379. doi: 10.1038/457379d.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19158768" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bees/physiology ; *Biological Evolution ; History, 20th Century ; Humans
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  • 61
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    Nature Publishing Group (NPG)
    Publication Date: 2009-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trounson, Alan -- England -- Nature. 2009 Mar 12;458(7235):161. doi: 10.1038/458161a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute for Regenerative Medicine, 210 King Street, San Francisco, California 94107, USA. atrounson@cirm.ca.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19279628" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cellular Reprogramming ; China ; Cloning, Organism/*history ; History, 20th Century ; History, 21st Century ; International Cooperation ; Nuclear Transfer Techniques/*history ; United States
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  • 62
    Publication Date: 2009-05-22
    Description: Lunar rocks and impact melts, lunar and asteroidal meteorites, and an ancient martian meteorite record thermal metamorphic events with ages that group around and/or do not exceed 3.9 Gyr. That such a diverse suite of solar system materials share this feature is interpreted to be the result of a post-primary-accretion cataclysmic spike in the number of impacts commonly referred to as the late heavy bombardment (LHB). Despite its obvious significance to the preservation of crust and the survivability of an emergent biosphere, the thermal effects of this bombardment on the young Earth remain poorly constrained. Here we report numerical models constructed to probe the degree of thermal metamorphism in the crust in the effort to recreate the effect of the LHB on the Earth as a whole; outputs were used to assess habitable volumes of crust for a possible near-surface and subsurface primordial microbial biosphere. Our analysis shows that there is no plausible situation in which the habitable zone was fully sterilized on Earth, at least since the termination of primary accretion of the planets and the postulated impact origin of the Moon. Our results explain the root location of hyperthermophilic bacteria in the phylogenetic tree for 16S small-subunit ribosomal RNA, and bode well for the persistence of microbial biospheres even on planetary bodies strongly reworked by impacts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abramov, Oleg -- Mojzsis, Stephen J -- England -- Nature. 2009 May 21;459(7245):419-22. doi: 10.1038/nature08015.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Colorado, Department of Geological Sciences, 2200 Colorado Avenue, UCB 399, Boulder, Colorado 80309-0399, USA. oleg.abramov@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19458721" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/genetics/*isolation & purification ; *Earth (Planet) ; Ecosystem ; History, Ancient ; Hot Temperature ; *Meteoroids ; *Models, Biological ; *Moon ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sterilization ; Time Factors
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  • 63
    Publication Date: 2009-11-10
    Description: Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells can be achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority of donor somatic cells can be reprogrammed to pluripotency. Here we demonstrate that reprogramming by these transcription factors is a continuous stochastic process where almost all mouse donor cells eventually give rise to iPS cells on continued growth and transcription factor expression. Additional inhibition of the p53/p21 pathway or overexpression of Lin28 increased the cell division rate and resulted in an accelerated kinetics of iPS cell formation that was directly proportional to the increase in cell proliferation. In contrast, Nanog overexpression accelerated reprogramming in a predominantly cell-division-rate-independent manner. Quantitative analyses define distinct cell-division-rate-dependent and -independent modes for accelerating the stochastic course of reprogramming, and suggest that the number of cell divisions is a key parameter driving epigenetic reprogramming to pluripotency.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789972/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789972/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanna, Jacob -- Saha, Krishanu -- Pando, Bernardo -- van Zon, Jeroen -- Lengner, Christopher J -- Creyghton, Menno P -- van Oudenaarden, Alexander -- Jaenisch, Rudolf -- R01 CA087869/CA/NCI NIH HHS/ -- R01 CA087869-09/CA/NCI NIH HHS/ -- R01 HD045022/HD/NICHD NIH HHS/ -- R01 HD045022-06/HD/NICHD NIH HHS/ -- R01-CA087869/CA/NCI NIH HHS/ -- R01-HDO45022/PHS HHS/ -- R37 CA084198/CA/NCI NIH HHS/ -- R37 CA084198-09/CA/NCI NIH HHS/ -- R37-CA084198/CA/NCI NIH HHS/ -- U54CA143874/CA/NCI NIH HHS/ -- England -- Nature. 2009 Dec 3;462(7273):595-601. doi: 10.1038/nature08592. Epub 2009 Nov 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA. Hanna@wi.mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19898493" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Differentiation ; Cell Division ; Cell Line ; *Cellular Reprogramming ; Gene Expression Regulation, Developmental ; Mice ; Mice, SCID ; Models, Biological ; Pluripotent Stem Cells/*cytology/*metabolism ; Time Factors ; Transcription Factors/genetics/metabolism
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  • 64
    Publication Date: 2009-04-03
    Description: Explaining the ecological causes of evolutionary diversification is a major focus of biology, but surprisingly little has been said about the effects of evolutionary diversification on ecosystems. The number of species in an ecosystem and their traits are key predictors of many ecosystem-level processes, such as rates of productivity, biomass sequestration and decomposition. Here we demonstrate short-term ecosystem-level effects of adaptive radiation in the threespine stickleback (Gasterosteus aculeatus) over the past 10,000 years. These fish have undergone recent parallel diversification in several lakes in coastal British Columbia, resulting in the formation of two specialized species (benthic and limnetic) from a generalist ancestor. Using a mesocosm experiment, we demonstrate that this diversification has strong effects on ecosystems, affecting prey community structure, total primary production, and the nature of dissolved organic materials that regulate the spectral properties of light transmission in the system. However, these ecosystem effects do not simply increase in their relative strength with increasing specialization and species richness; instead, they reflect the complex and indirect consequences of ecosystem engineering by sticklebacks. It is well known that ecological factors influence adaptive radiation. We demonstrate that adaptive radiation, even over short timescales, can have profound effects on ecosystems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harmon, Luke J -- Matthews, Blake -- Des Roches, Simone -- Chase, Jonathan M -- Shurin, Jonathan B -- Schluter, Dolph -- England -- Nature. 2009 Apr 30;458(7242):1167-70. doi: 10.1038/nature07974. Epub 2009 Apr 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844-3051, USA. lukeh@uidaho.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19339968" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Biological Evolution ; Biomass ; British Columbia ; *Ecosystem ; Fishes/*classification/*physiology ; Food Chain ; Fresh Water ; Genetic Speciation ; Models, Biological ; Population Density ; Predatory Behavior
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  • 65
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    Nature Publishing Group (NPG)
    Publication Date: 2009-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, Daniel S -- England -- Nature. 2009 Aug 6;460(7256):695-6. doi: 10.1038/460695a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661905" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Art/history ; Birds/anatomy & histology ; Bone and Bones ; Culture ; Germany ; History, Ancient ; Music/*history
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  • 66
    Publication Date: 2009-06-19
    Description: A profound global climate shift took place at the Eocene-Oligocene transition ( approximately 33.5 million years ago) when Cretaceous/early Palaeogene greenhouse conditions gave way to icehouse conditions. During this interval, changes in the Earth's orbit and a long-term drop in atmospheric carbon dioxide concentrations resulted in both the growth of Antarctic ice sheets to approximately their modern size and the appearance of Northern Hemisphere glacial ice. However, palaeoclimatic studies of this interval are contradictory: although some analyses indicate no major climatic changes, others imply cooler temperatures, increased seasonality and/or aridity. Climatic conditions in high northern latitudes over this interval are particularly poorly known. Here we present northern high-latitude terrestrial climate estimates for the Eocene to Oligocene interval, based on bioclimatic analysis of terrestrially derived spore and pollen assemblages preserved in marine sediments from the Norwegian-Greenland Sea. Our data indicate a cooling of approximately 5 degrees C in cold-month (winter) mean temperatures to 0-2 degrees C, and a concomitant increased seasonality before the Oi-1 glaciation event. These data indicate that a cooling component is indeed incorporated in the delta(18)O isotope shift across the Eocene-Oligocene transition. However, the relatively warm summer temperatures at that time mean that continental ice on East Greenland was probably restricted to alpine outlet glaciers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eldrett, James S -- Greenwood, David R -- Harding, Ian C -- Huber, Matthew -- England -- Nature. 2009 Jun 18;459(7249):969-73. doi: 10.1038/nature08069.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Shell Exploration and Production UK Ltd, 1 Altens Farm Road, Nigg, Aberdeen, AB12 3FY, UK. james.eldrett@shell.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19536261" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; Geologic Sediments/analysis ; Greenland ; History, Ancient ; Ice Cover ; Norway ; Oceans and Seas ; Pollen ; *Seasons ; Spores ; *Temperature
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  • 67
    Publication Date: 2009-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chakravarti, Aravinda -- England -- Nature. 2009 Sep 24;461(7263):487-8. doi: 10.1038/461487a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19779444" target="_blank"〉PubMed〈/a〉
    Keywords: Asia/ethnology ; Continental Population Groups/genetics/history ; Ethnic Groups/*genetics/history ; Europe/ethnology ; Female ; Founder Effect ; Genetics, Population ; Genome, Human/genetics ; Genomics ; Genotype ; History, 16th Century ; History, 20th Century ; History, Ancient ; Humans ; India ; Language ; Male ; *Phylogeny ; Polymorphism, Single Nucleotide/genetics
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  • 68
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    Nature Publishing Group (NPG)
    Publication Date: 2009-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hartung, Thomas -- England -- Nature. 2009 Jul 9;460(7252):208-12. doi: 10.1038/460208a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Health Sciences at the Johns Hopkins University Bloomberg School of Public Health, USA. thartung@jhsph.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19587762" target="_blank"〉PubMed〈/a〉
    Keywords: Adverse Drug Reaction Reporting Systems ; Animals ; False Positive Reactions ; History, 20th Century ; Humans ; Models, Animal ; Rats ; Reproducibility of Results ; Research Design ; Toxicity Tests ; Toxicology/history/*methods/*trends
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  • 69
    Publication Date: 2009-09-26
    Description: Reconstructions of atmospheric CO(2) concentrations based on Antarctic ice cores reveal significant changes during the Holocene epoch, but the processes responsible for these changes in CO(2) concentrations have not been unambiguously identified. Distinct characteristics in the carbon isotope signatures of the major carbon reservoirs (ocean, biosphere, sediments and atmosphere) constrain variations in the CO(2) fluxes between those reservoirs. Here we present a highly resolved atmospheric delta(13)C record for the past 11,000 years from measurements on atmospheric CO(2) trapped in an Antarctic ice core. From mass-balance inverse model calculations performed with a simplified carbon cycle model, we show that the decrease in atmospheric CO(2) of about 5 parts per million by volume (p.p.m.v.). The increase in delta(13)C of about 0.25 per thousand during the early Holocene is most probably the result of a combination of carbon uptake of about 290 gigatonnes of carbon by the land biosphere and carbon release from the ocean in response to carbonate compensation of the terrestrial uptake during the termination of the last ice age. The 20 p.p.m.v. increase of atmospheric CO(2) and the small decrease in delta(13)C of about 0.05 per thousand during the later Holocene can mostly be explained by contributions from carbonate compensation of earlier land-biosphere uptake and coral reef formation, with only a minor contribution from a small decrease of the land-biosphere carbon inventory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elsig, Joachim -- Schmitt, Jochen -- Leuenberger, Daiana -- Schneider, Robert -- Eyer, Marc -- Leuenberger, Markus -- Joos, Fortunat -- Fischer, Hubertus -- Stocker, Thomas F -- England -- Nature. 2009 Sep 24;461(7263):507-10. doi: 10.1038/nature08393.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Climate and Environmental Physics, Physics Institute, University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19779448" target="_blank"〉PubMed〈/a〉
    Keywords: Air/analysis ; Animals ; Antarctic Regions ; Anthozoa/growth & development/metabolism ; Atmosphere/chemistry ; Carbon/*analysis/*metabolism ; Carbon Dioxide/analysis/*metabolism ; Carbon Isotopes ; Climate ; Ecosystem ; History, Ancient ; Ice Cover/*chemistry ; Time Factors
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  • 70
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    Nature Publishing Group (NPG)
    Publication Date: 2009-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aguzzi, Adriano -- England -- Nature. 2009 Jun 18;459(7249):924-5. doi: 10.1038/459924a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19536253" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid/metabolism ; Animals ; Humans ; Models, Biological ; Peptides/metabolism ; Prion Diseases/*metabolism/pathology/transmission ; Prions/*chemistry/*metabolism ; Protein Denaturation ; tau Proteins/genetics/metabolism
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  • 71
    Publication Date: 2009-07-15
    Description: Recent finds demonstrate that internal fertilization and viviparity (live birth) were more widespread in the Placodermi, an extinct group of armoured fishes, than was previously realized. Placoderms represent the sister group of the crown group jawed vertebrates (Gnathostomata), making their mode(s) of reproduction potentially informative about primitive gnathostome conditions. An ossified pelvic fin basipterygium discovered in the arthrodire Incisoscutum ritchiei was hypothesized to be identical in males and females, with males presumed to have an additional cartilaginous element or series forming a clasper. Here we report the discovery of a completely ossified pelvic clasper in Incisoscutum ritchiei (WAM 03.3.28) which shows that this interpretation was incorrect: the basipterygium described previously is in fact unique to females. The male clasper is a slender rod attached to a square basal plate that articulates directly with the pelvis. It carries a small cap of dermal bone covered in denticles and small hooks that may be homologous with the much larger dermal component of the ptyctodont clasper.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahlberg, Per -- Trinajstic, Kate -- Johanson, Zerina -- Long, John -- England -- Nature. 2009 Aug 13;460(7257):888-9. doi: 10.1038/nature08176. Epub 2009 Jul 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Uppsala University, Norbyvagen 18A, 752 36 Uppsala, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19597477" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Structures/anatomy & histology/*physiology ; Animals ; Female ; Fertilization/*physiology ; Fishes/*anatomy & histology/*physiology ; Fossils ; History, Ancient ; Male ; Pelvis/anatomy & histology ; Viviparity, Nonmammalian/physiology
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  • 72
    Publication Date: 2009-10-02
    Description: Down Syndrome cell adhesion molecule (Dscam) genes encode neuronal cell recognition proteins of the immunoglobulin superfamily. In Drosophila, Dscam1 generates 19,008 different ectodomains by alternative splicing of three exon clusters, each encoding half or a complete variable immunoglobulin domain. Identical isoforms bind to each other, but rarely to isoforms differing at any one of the variable immunoglobulin domains. Binding between isoforms on opposing membranes promotes repulsion. Isoform diversity provides the molecular basis for neurite self-avoidance. Self-avoidance refers to the tendency of branches from the same neuron (self-branches) to selectively avoid one another. To ensure that repulsion is restricted to self-branches, different neurons express different sets of isoforms in a biased stochastic fashion. Genetic studies demonstrated that Dscam1 diversity has a profound role in wiring the fly brain. Here we show how many isoforms are required to provide an identification system that prevents non-self branches from inappropriately recognizing each other. Using homologous recombination, we generated mutant animals encoding 12, 24, 576 and 1,152 potential isoforms. Mutant animals with deletions encoding 4,752 and 14,256 isoforms were also analysed. Branching phenotypes were assessed in three classes of neurons. Branching patterns improved as the potential number of isoforms increased, and this was independent of the identity of the isoforms. Although branching defects in animals with 1,152 potential isoforms remained substantial, animals with 4,752 isoforms were indistinguishable from wild-type controls. Mathematical modelling studies were consistent with the experimental results that thousands of isoforms are necessary to ensure acquisition of unique Dscam1 identities in many neurons. We conclude that thousands of isoforms are essential to provide neurons with a robust discrimination mechanism to distinguish between self and non-self during self-avoidance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836808/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836808/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hattori, Daisuke -- Chen, Yi -- Matthews, Benjamin J -- Salwinski, Lukasz -- Sabatti, Chiara -- Grueber, Wesley B -- Zipursky, S Lawrence -- F31 NS060341/NS/NINDS NIH HHS/ -- R01 DC006485/DC/NIDCD NIH HHS/ -- R01 DC006485-07/DC/NIDCD NIH HHS/ -- R01 HD040279/HD/NICHD NIH HHS/ -- R01 HD040279-05/HD/NICHD NIH HHS/ -- T32 HD007430/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2009 Oct 1;461(7264):644-8. doi: 10.1038/nature08431.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19794492" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Alternative Splicing ; Animals ; Brain/cytology/metabolism ; Cell Adhesion Molecules/*chemistry/genetics/*metabolism ; Drosophila Proteins/*chemistry/genetics/*metabolism ; Drosophila melanogaster/*cytology/genetics/*metabolism ; Female ; Male ; Models, Biological ; Mushroom Bodies/cytology/metabolism ; Neurites/*metabolism ; Protein Isoforms/chemistry/genetics/metabolism ; Sequence Deletion ; Stochastic Processes
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  • 73
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    Nature Publishing Group (NPG)
    Publication Date: 2009-09-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicholls, Henry -- England -- Nature. 2009 Sep 10;461(7261):164-6. doi: 10.1038/461164a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19741680" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Developmental Biology ; Fossils ; Hagfishes/*anatomy & histology/*classification/embryology/genetics ; Head/anatomy & histology ; Humans ; Lampreys/*anatomy & histology/*classification/embryology/genetics ; MicroRNAs/genetics/metabolism ; Models, Biological ; Phylogeny ; Sharks/anatomy & histology/classification/embryology
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  • 74
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    Nature Publishing Group (NPG)
    Publication Date: 2009-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiermeier, Quirin -- England -- Nature. 2009 Oct 1;461(7264):590-1. doi: 10.1038/461590a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19794471" target="_blank"〉PubMed〈/a〉
    Keywords: Europe, Eastern ; History, 20th Century ; History, 21st Century ; Research Personnel/statistics & numerical data ; Science/*economics/history/manpower/standards
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  • 75
    Publication Date: 2009-02-20
    Description: The assembly of complex structures out of simple colloidal building blocks is of practical interest for building materials with unique optical properties (for example photonic crystals and DNA biosensors) and is of fundamental importance in improving our understanding of self-assembly processes occurring on molecular to macroscopic length scales. Here we demonstrate a self-assembly principle that is capable of organizing a diverse set of colloidal particles into highly reproducible, rotationally symmetric arrangements. The structures are assembled using the magnetostatic interaction between effectively diamagnetic and paramagnetic particles within a magnetized ferrofluid. The resulting multipolar geometries resemble electrostatic charge configurations such as axial quadrupoles ('Saturn rings'), axial octupoles ('flowers'), linear quadrupoles (poles) and mixed multipole arrangements ('two tone'), which represent just a few examples of the type of structure that can be built using this technique.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erb, Randall M -- Son, Hui S -- Samanta, Bappaditya -- Rotello, Vincent M -- Yellen, Benjamin B -- England -- Nature. 2009 Feb 19;457(7232):999-1002. doi: 10.1038/nature07766.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke University, Department of Mechanical Engineering and Materials Science, Center for Biologically Inspired Materials and Material Systems, Box 90300, Hudson Hall, Durham, North Carolina 27708, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225522" target="_blank"〉PubMed〈/a〉
    Keywords: Colloids/*chemistry ; *Magnetics ; Microscopy, Electron, Scanning ; Microspheres ; Models, Biological ; Nanostructures/chemistry/ultrastructure ; Particle Size ; Water/chemistry
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  • 76
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    Nature Publishing Group (NPG)
    Publication Date: 2009-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiermeier, Quirin -- England -- Nature. 2009 Oct 1;461(7264):586-9. doi: 10.1038/461586a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19794470" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Berlin ; Communism/history ; Czechoslovakia ; Democracy ; Education, Graduate ; Europe, Eastern ; Financing, Organized ; History, 20th Century ; History, 21st Century ; Humans ; Internationality ; Israel ; Poland ; Politics ; Research Personnel/economics/*education/*history/standards ; Switzerland ; United States
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  • 77
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    Nature Publishing Group (NPG)
    Publication Date: 2009-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charron, Dominique J -- England -- Nature. 2009 Jul 16;460(7253):338. doi: 10.1038/460338a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire Jean Dausset, Hopital Saint-Louis, and the Institut Universitaire d'Hematologie, 75010 Paris, France. dominique.charron@sls.aphp.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19606138" target="_blank"〉PubMed〈/a〉
    Keywords: Allergy and Immunology/*history ; France ; Genetic Predisposition to Disease ; HLA Antigens/genetics/*history/*immunology ; History, 20th Century ; Humans ; Polymorphism, Genetic ; Transplantation Immunology
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  • 78
    Publication Date: 2009-07-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicotera, Pierluigi -- MC_U132664972/Medical Research Council/United Kingdom -- England -- Nature. 2009 Jul 2;460(7251):135. doi: 10.1038/nj7251-135a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19582898" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*history/*organization & administration ; Germany ; History, 20th Century ; History, 21st Century ; Humans ; *Neurodegenerative Diseases/metabolism/pathology
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  • 79
    Publication Date: 2009-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, Nicola J -- Barres, Ben A -- England -- Nature. 2009 Feb 5;457(7230):675-7. doi: 10.1038/457675a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19194443" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/physiology ; Biological Evolution ; Brain/*cytology/embryology/pathology/*physiology ; Cell Communication ; Cell Lineage ; Homeostasis ; Humans ; Models, Biological ; Nerve Net/physiology ; Nervous System Diseases/pathology/physiopathology ; Neural Pathways/physiology ; Neuroglia/classification/cytology/pathology/*physiology ; Neurons/cytology/physiology ; Oligodendroglia/pathology/physiology ; Schwann Cells/pathology/physiology
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  • 80
    Publication Date: 2009-05-02
    Description: Global efforts to mitigate climate change are guided by projections of future temperatures. But the eventual equilibrium global mean temperature associated with a given stabilization level of atmospheric greenhouse gas concentrations remains uncertain, complicating the setting of stabilization targets to avoid potentially dangerous levels of global warming. Similar problems apply to the carbon cycle: observations currently provide only a weak constraint on the response to future emissions. Here we use ensemble simulations of simple climate-carbon-cycle models constrained by observations and projections from more comprehensive models to simulate the temperature response to a broad range of carbon dioxide emission pathways. We find that the peak warming caused by a given cumulative carbon dioxide emission is better constrained than the warming response to a stabilization scenario. Furthermore, the relationship between cumulative emissions and peak warming is remarkably insensitive to the emission pathway (timing of emissions or peak emission rate). Hence policy targets based on limiting cumulative emissions of carbon dioxide are likely to be more robust to scientific uncertainty than emission-rate or concentration targets. Total anthropogenic emissions of one trillion tonnes of carbon (3.67 trillion tonnes of CO(2)), about half of which has already been emitted since industrialization began, results in a most likely peak carbon-dioxide-induced warming of 2 degrees C above pre-industrial temperatures, with a 5-95% confidence interval of 1.3-3.9 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, Myles R -- Frame, David J -- Huntingford, Chris -- Jones, Chris D -- Lowe, Jason A -- Meinshausen, Malte -- Meinshausen, Nicolai -- England -- Nature. 2009 Apr 30;458(7242):1163-6. doi: 10.1038/nature08019.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Oxford, OX1 3PU, UK. myles.allen@physics.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19407800" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/*chemistry ; Benchmarking ; Carbon/*analysis ; Carbon Dioxide/*analysis ; Computer Simulation ; *Greenhouse Effect ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Human Activities/history ; Industry/history ; *Models, Theoretical ; *Temperature ; Time Factors ; Uncertainty
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  • 81
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    Nature Publishing Group (NPG)
    Publication Date: 2009-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Noorden, Richard -- England -- Nature. 2009 Oct 15;461(7266):860. doi: 10.1038/461860a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19829342" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/pharmacology ; *Chemistry/history ; Crystallization/history ; *Crystallography, X-Ray/history ; History, 20th Century ; History, 21st Century ; Humans ; *Nobel Prize ; Ribosomes/*chemistry/drug effects/metabolism
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  • 82
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    Nature Publishing Group (NPG)
    Publication Date: 2009-06-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fara, Patricia -- England -- Nature. 2009 Jun 4;459(7247):642-4. doi: 10.1038/459642a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clare College, University of Cambridge CB2 1TL, UK. pf10006@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19494897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Microscopy/*history/*instrumentation/standards
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  • 83
    Publication Date: 2009-02-06
    Description: The largest extant snakes live in the tropics of South America and southeast Asia where high temperatures facilitate the evolution of large body sizes among air-breathing animals whose body temperatures are dependant on ambient environmental temperatures (poikilothermy). Very little is known about ancient tropical terrestrial ecosystems, limiting our understanding of the evolution of giant snakes and their relationship to climate in the past. Here we describe a boid snake from the oldest known neotropical rainforest fauna from the Cerrejon Formation (58-60 Myr ago) in northeastern Colombia. We estimate a body length of 13 m and a mass of 1,135 kg, making it the largest known snake. The maximum size of poikilothermic animals at a given temperature is limited by metabolic rate, and a snake of this size would require a minimum mean annual temperature of 30-34 degrees C to survive. This estimate is consistent with hypotheses of hot Palaeocene neotropics with high concentrations of atmospheric CO(2) based on climate models. Comparison of palaeotemperature estimates from the equator to those from South American mid-latitudes indicates a relatively steep temperature gradient during the early Palaeogene greenhouse, similar to that of today. Depositional environments and faunal composition of the Cerrejon Formation indicate an anaconda-like ecology for the giant snake, and an earliest Cenozoic origin of neotropical vertebrate faunas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Head, Jason J -- Bloch, Jonathan I -- Hastings, Alexander K -- Bourque, Jason R -- Cadena, Edwin A -- Herrera, Fabiany A -- Polly, P David -- Jaramillo, Carlos A -- England -- Nature. 2009 Feb 5;457(7230):715-7. doi: 10.1038/nature07671.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Toronto, Mississauga, Ontario L5L 1C6, Canada. jason.head@utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19194448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere/chemistry ; Biological Evolution ; *Body Size ; Body Temperature Regulation ; Boidae/*anatomy & histology/metabolism ; Carbon Dioxide/analysis ; Colombia ; Energy Metabolism ; *Fossils ; History, Ancient ; *Temperature ; *Tropical Climate
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  • 84
    Publication Date: 2009-03-28
    Description: Rivers are the dominant source of many elements and isotopes to the ocean. But this input from the continents is not balanced by the loss of the elements and isotopes through hydrothermal and sedimentary exchange with the oceanic crust, or by temporal changes in the marine inventory for elements that are demonstrably not in steady state. To resolve the problem of the observed imbalance in marine geochemical budgets, attention has been focused on uncertainties in the hydrothermal and sedimentary fluxes. In recent Earth history, temporally dynamic chemical weathering fluxes from the continents are an inevitable consequence of periodic glaciations. Chemical weathering rates on modern Earth are likely to remain far from equilibrium owing to the physical production of finely ground material at glacial terminations that acts as a fertile substrate for chemical weathering. Here we explore the implications of temporal changes in the riverine chemical weathering flux for oceanic geochemical budgets. We contend that the riverine flux obtained from observations of modern rivers is broadly accurate, but not representative of timescales appropriate for elements with oceanic residence longer than Quaternary glacial-interglacial cycles. We suggest that the pulse of rapid chemical weathering initiated at the last deglaciation has not yet decayed away and that weathering rates remain about two to three times the average for an entire late Quaternary glacial cycle. Taking into account the effect of the suggested non-steady-state process on the silicate weathering flux helps to reconcile the modelled marine strontium isotope budget with available data. Overall, we conclude that consideration of the temporal variability in riverine fluxes largely ameliorates long-standing problems with chemical and isotopic mass balances in the ocean.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vance, Derek -- Teagle, Damon A H -- Foster, Gavin L -- England -- Nature. 2009 Mar 26;458(7237):493-6. doi: 10.1038/nature07828.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bristol Isotope Group, Department of Earth Sciences, University of Bristol, Wills Memorial Building, Bristol BS8 1RJ, UK. d.vance@bristol.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325631" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/chemistry ; Carbon Dioxide/analysis ; Carbonates/analysis/chemistry ; Geologic Sediments/*chemistry ; History, Ancient ; Ice Cover ; Osmium/analysis ; Rivers/*chemistry ; Seawater/*chemistry ; Strontium/analysis/chemistry ; Strontium Isotopes ; Temperature
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  • 85
    Publication Date: 2009-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heckenberger, Michael -- England -- Nature. 2009 Apr 9;458(7239):683. doi: 10.1038/458683e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Florida, Gainesville, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19360041" target="_blank"〉PubMed〈/a〉
    Keywords: Archaeology ; Civilization/*history ; History, Ancient ; History, Medieval ; Humans ; Peru ; Urbanization/*history
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  • 86
    Publication Date: 2009-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vance, Erik -- England -- Nature. 2009 May 28;459(7246):498-9. doi: 10.1038/459498a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478760" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols/analysis/chemistry ; Agriculture ; Air Pollutants/analysis/chemistry ; Altitude ; Atmosphere/*chemistry ; California ; History, 20th Century ; History, 21st Century ; Ozone/analysis/chemistry ; Trees/chemistry/*metabolism ; Volatile Organic Compounds/*analysis/chemistry
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  • 87
    Publication Date: 2009-09-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vasquez, Valeria -- Perozo, Eduardo -- England -- Nature. 2009 Sep 3;461(7260):47-9. doi: 10.1038/461047a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19727188" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/*chemistry/*metabolism ; Crystallography, X-Ray ; Ion Channel Gating/*physiology ; Ion Channels/*chemistry/*metabolism ; Models, Biological ; Models, Molecular ; Mycobacterium tuberculosis/chemistry ; Pressure ; Protein Structure, Quaternary ; Staphylococcus aureus/*chemistry
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  • 88
    Publication Date: 2009-07-25
    Description: Spatially synchronized fluctuations in system state are common in physical and biological systems ranging from individual atoms to species as diverse as viruses, insects and mammals. Although the causal factors are well known for many synchronized phenomena, several processes concurrently have an impact on spatial synchrony of species, making their separate effects and interactions difficult to quantify. Here we develop a general stochastic model of predator-prey spatial dynamics to predict the outcome of a laboratory microcosm experiment testing for interactions among all known synchronizing factors: (1) dispersal of individuals between populations; (2) spatially synchronous fluctuations in exogenous environmental factors (the Moran effect); and (3) interactions with other species (for example, predators) that are themselves spatially synchronized. The Moran effect synchronized populations of the ciliate protist Tetrahymena pyriformis; however, dispersal only synchronized prey populations in the presence of the predator Euplotes patella. Both model and data indicate that synchrony depends on cyclic dynamics generated by the predator. Dispersal, but not the Moran effect, 'phase-locks' cycles, which otherwise become 'decoherent' and drift out of phase. In the absence of cycles, phase-locking is not possible and the synchronizing effect of dispersal is negligible. Interspecific interactions determine population synchrony, not by providing an additional source of synchronized fluctuations, but by altering population dynamics and thereby enhancing the action of dispersal. Our results are robust to wide variation in model parameters representative of many natural predator-prey or host-pathogen systems. This explains why cyclic systems provide many of the most dramatic examples of spatial synchrony in nature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vasseur, David A -- Fox, Jeremy W -- England -- Nature. 2009 Aug 20;460(7258):1007-10. doi: 10.1038/nature08208. Epub 2009 Jul 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA. david.vasseur@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19626006" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Euplotes/*physiology ; *Food Chain ; Models, Biological ; Population Dynamics ; Predatory Behavior/*physiology ; Stochastic Processes ; Tetrahymena pyriformis/*physiology
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  • 89
    Publication Date: 2009-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arthur, Michael A -- England -- Nature. 2009 Aug 6;460(7256):698-9. doi: 10.1038/460698a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661908" target="_blank"〉PubMed〈/a〉
    Keywords: Calcium Carbonate/chemistry ; Carbon/chemistry/*metabolism ; Carbon Isotopes ; Carbonates/*analysis/*chemistry ; Earth (Planet) ; Geologic Sediments/*chemistry ; History, Ancient ; Oceans and Seas ; Oxygen/analysis ; Oxygen Isotopes ; Photosynthesis ; Plants/metabolism
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  • 90
    Publication Date: 2009-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henebry, Geoffrey M -- England -- Nature. 2009 Feb 26;457(7233):1089-90. doi: 10.1038/4571089a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19242461" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*history ; Carbon/*analysis ; Crops, Agricultural/metabolism ; *Ecosystem ; History, 20th Century ; Poaceae/metabolism ; Republic of Belarus ; Russia ; Soil/*analysis ; Ukraine
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  • 91
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    Nature Publishing Group (NPG)
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hertz, Noreena -- England -- Nature. 2009 Feb 19;457(7232):962-3. doi: 10.1038/457962a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rotterdam School of Management, Erasmus University, the Netherlands. n.hertz@jbs.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225504" target="_blank"〉PubMed〈/a〉
    Keywords: *Capitalism ; Child ; Drug Industry/economics/legislation & jurisprudence ; Food Industry/legislation & jurisprudence ; History, 20th Century ; History, 21st Century ; Humans ; Internationality
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  • 92
    Publication Date: 2009-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemarchand, Damien -- England -- Nature. 2009 Oct 22;461(7267):1065-6. doi: 10.1038/4611065a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19847252" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; Atmosphere/chemistry ; Boron ; Carbon Dioxide/analysis ; *Climate Change ; Foraminifera/chemistry ; Fossils ; History, Ancient ; Hydrogen-Ion Concentration ; *Ice Cover/chemistry ; Isotopes ; Seawater/chemistry ; Temperature
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  • 93
    Publication Date: 2009-06-12
    Description: Natural products containing phosphorus-carbon bonds have found widespread use in medicine and agriculture. One such compound, phosphinothricin tripeptide, contains the unusual amino acid phosphinothricin attached to two alanine residues. Synthetic phosphinothricin (glufosinate) is a component of two top-selling herbicides (Basta and Liberty), and is widely used with resistant transgenic crops including corn, cotton and canola. Recent genetic and biochemical studies showed that during phosphinothricin tripeptide biosynthesis 2-hydroxyethylphosphonate (HEP) is converted to hydroxymethylphosphonate (HMP). Here we report the in vitro reconstitution of this unprecedented C(sp(3))-C(sp(3)) bond cleavage reaction and X-ray crystal structures of the enzyme. The protein is a mononuclear non-haem iron(ii)-dependent dioxygenase that converts HEP to HMP and formate. In contrast to most other members of this family, the oxidative consumption of HEP does not require additional cofactors or the input of exogenous electrons. The current study expands the scope of reactions catalysed by the 2-His-1-carboxylate mononuclear non-haem iron family of enzymes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874955/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874955/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cicchillo, Robert M -- Zhang, Houjin -- Blodgett, Joshua A V -- Whitteck, John T -- Li, Gongyong -- Nair, Satish K -- van der Donk, Wilfred A -- Metcalf, William W -- P01 GM077596/GM/NIGMS NIH HHS/ -- P01 GM077596-03/GM/NIGMS NIH HHS/ -- R01 GM059334/GM/NIGMS NIH HHS/ -- R01 GM059334-09/GM/NIGMS NIH HHS/ -- R01 GM59334/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Jun 11;459(7248):871-4. doi: 10.1038/nature07972.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19516340" target="_blank"〉PubMed〈/a〉
    Keywords: Aminobutyrates/*chemistry/*metabolism ; Biocatalysis ; Crystallography, X-Ray ; Dioxygenases/chemistry/genetics/*metabolism ; Escherichia coli ; Formates/metabolism ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Models, Biological ; Models, Molecular ; Molecular Conformation ; Organophosphonates/metabolism
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  • 94
    Publication Date: 2009-02-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Attenborough, David -- England -- Nature. 2009 Feb 19;457(7232):967. doi: 10.1038/457967a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225509" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Biology/history ; Greenhouse Effect ; History, 19th Century ; History, 20th Century ; Human Activities ; *Television
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  • 95
    Publication Date: 2009-08-14
    Description: Ecological communities characteristically contain a wide diversity of species with important functional, economic and aesthetic value. Ecologists have long questioned how this diversity is maintained. Classic theory shows that stable coexistence requires competitors to differ in their niches; this has motivated numerous investigations of ecological differences presumed to maintain diversity. That niche differences are key to coexistence, however, has recently been challenged by the neutral theory of biodiversity, which explains coexistence with the equivalence of competitors. The ensuing controversy has motivated calls for a better understanding of the collective importance of niche differences for the diversity observed in ecological communities. Here we integrate theory and experimentation to show that niche differences collectively stabilize the dynamics of experimental communities of serpentine annual plants. We used field-parameterized population models to develop a null expectation for community dynamics without the stabilizing effects of niche differences. The population growth rates predicted by this null model varied by several orders of magnitude between species, which is sufficient for rapid competitive exclusion. Moreover, after two generations of community change in the field, Shannon diversity was over 50 per cent greater in communities stabilized by niche differences relative to those exhibiting dynamics predicted by the null model. Finally, in an experiment manipulating species' relative abundances, population growth rates increased when species became rare--the demographic signature of niche differences. Our work thus provides strong evidence that species differences have a critical role in stabilizing species diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, Jonathan M -- HilleRisLambers, Janneke -- England -- Nature. 2009 Sep 10;461(7261):254-7. doi: 10.1038/nature08251. Epub 2009 Aug 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, California 93106, USA. levine@lifesci.ucsb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19675568" target="_blank"〉PubMed〈/a〉
    Keywords: *Biodiversity ; California ; *Ecosystem ; Models, Biological ; Plant Development ; *Plant Physiological Phenomena ; Plants/classification ; Population Dynamics ; Seeds/physiology
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 96
    Publication Date: 2009-09-18
    Description: On entering an era of global warming, the stability of the Greenland ice sheet (GIS) is an important concern, especially in the light of new evidence of rapidly changing flow and melt conditions at the GIS margins. Studying the response of the GIS to past climatic change may help to advance our understanding of GIS dynamics. The previous interpretation of evidence from stable isotopes (delta(18)O) in water from GIS ice cores was that Holocene climate variability on the GIS differed spatially and that a consistent Holocene climate optimum-the unusually warm period from about 9,000 to 6,000 years ago found in many northern-latitude palaeoclimate records-did not exist. Here we extract both the Greenland Holocene temperature history and the evolution of GIS surface elevation at four GIS locations. We achieve this by comparing delta(18)O from GIS ice cores with delta(18)O from ice cores from small marginal icecaps. Contrary to the earlier interpretation of delta(18)O evidence from ice cores, our new temperature history reveals a pronounced Holocene climatic optimum in Greenland coinciding with maximum thinning near the GIS margins. Our delta(18)O-based results are corroborated by the air content of ice cores, a proxy for surface elevation. State-of-the-art ice sheet models are generally found to be underestimating the extent and changes in GIS elevation and area; our findings may help to improve the ability of models to reproduce the GIS response to Holocene climate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vinther, B M -- Buchardt, S L -- Clausen, H B -- Dahl-Jensen, D -- Johnsen, S J -- Fisher, D A -- Koerner, R M -- Raynaud, D -- Lipenkov, V -- Andersen, K K -- Blunier, T -- Rasmussen, S O -- Steffensen, J P -- Svensson, A M -- England -- Nature. 2009 Sep 17;461(7262):385-8. doi: 10.1038/nature08355.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Ice and Climate, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen Oe, Denmark. bo@gfy.ku.dk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19759618" target="_blank"〉PubMed〈/a〉
    Keywords: Altitude ; *Greenhouse Effect ; Greenland ; History, Ancient ; *Ice Cover ; Oxygen/analysis ; Oxygen Isotopes ; Temperature
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 97
    Publication Date: 2009-08-29
    Description: Northern Hemisphere surface temperature reconstructions suggest that the late twentieth century was warmer than any other time during the past 500 years and possibly any time during the past 1,300 years (refs 1, 2). These temperature reconstructions are based largely on terrestrial records from extra-tropical or high-elevation sites; however, global average surface temperature changes closely follow those of the global tropics, which are 75% ocean. In particular, the tropical Indo-Pacific warm pool (IPWP) represents a major heat reservoir that both influences global atmospheric circulation and responds to remote northern high-latitude forcings. Here we present a decadally resolved continuous sea surface temperature (SST) reconstruction from the IPWP that spans the past two millennia and overlaps the instrumental record, enabling both a direct comparison of proxy data to the instrumental record and an evaluation of past changes in the context of twentieth century trends. Our record from the Makassar Strait, Indonesia, exhibits trends that are similar to a recent Northern Hemisphere temperature reconstruction. Reconstructed SST was, however, within error of modern values from about ad 1000 to ad 1250, towards the end of the Medieval Warm Period. SSTs during the Little Ice Age (approximately ad 1550-1850) were variable, and approximately 0.5 to 1 degrees C colder than modern values during the coldest intervals. A companion reconstruction of delta(18)O of sea water-a sea surface salinity and hydrology indicator-indicates a tight coupling with the East Asian monsoon system and remote control of IPWP hydrology on centennial-millennial timescales, rather than a dominant influence from local SST variation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oppo, Delia W -- Rosenthal, Yair -- Linsley, Braddock K -- England -- Nature. 2009 Aug 27;460(7259):1113-6. doi: 10.1038/nature08233.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology and Geophysics, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA. doppo@whoi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19713927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere/analysis ; Calibration ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; History, Medieval ; Ice Cover ; India ; Indonesia ; Oceans and Seas ; Oxygen Isotopes ; Pacific Ocean ; Plankton/metabolism ; Rain ; Records as Topic ; Salinity ; Seasons ; Seawater/*analysis ; *Temperature ; Time Factors ; Tropical Climate ; Weather
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 98
    Publication Date: 2009-09-18
    Description: Adaptive radiations often follow the evolution of key traits, such as the origin of the amniotic egg and the subsequent radiation of terrestrial vertebrates. The mechanism by which a species determines the sex of its offspring has been linked to critical ecological and life-history traits but not to major adaptive radiations, in part because sex-determining mechanisms do not fossilize. Here we establish a previously unknown coevolutionary relationship in 94 amniote species between sex-determining mechanism and whether a species bears live young or lays eggs. We use that relationship to predict the sex-determining mechanism in three independent lineages of extinct Mesozoic marine reptiles (mosasaurs, sauropterygians and ichthyosaurs), each of which is known from fossils to have evolved live birth. Our results indicate that each lineage evolved genotypic sex determination before acquiring live birth. This enabled their pelagic radiations, where the relatively stable temperatures of the open ocean constrain temperature-dependent sex determination in amniote species. Freed from the need to move and nest on land, extreme physical adaptations to a pelagic lifestyle evolved in each group, such as the fluked tails, dorsal fins and wing-shaped limbs of ichthyosaurs. With the inclusion of ichthyosaurs, mosasaurs and sauropterygians, genotypic sex determination is present in all known fully pelagic amniote groups (sea snakes, sirenians and cetaceans), suggesting that this mode of sex determination and the subsequent evolution of live birth are key traits required for marine adaptive radiations in amniote lineages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Organ, Chris L -- Janes, Daniel E -- Meade, Andrew -- Pagel, Mark -- 1 F32 GM075490-01/GM/NIGMS NIH HHS/ -- 5 F32 GM072494/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Sep 17;461(7262):389-92. doi: 10.1038/nature08350.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Museum of Comparative Zoology, Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA. corgan@oeb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19759619" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/genetics/physiology ; Algorithms ; Animals ; Bayes Theorem ; *Biological Evolution ; *Extinction, Biological ; Female ; Fossils ; Genotype ; History, Ancient ; Male ; Marine Biology ; Markov Chains ; Monte Carlo Method ; Oviposition/genetics/physiology ; Phylogeny ; Reptiles/classification/*genetics/*physiology ; Sex Chromosomes/*genetics ; *Sex Determination Processes ; Sex Ratio ; Temperature ; Viviparity, Nonmammalian/genetics/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 2009-02-20
    Description: The response of terrestrial vegetation to a globally changing environment is central to predictions of future levels of atmospheric carbon dioxide. The role of tropical forests is critical because they are carbon-dense and highly productive. Inventory plots across Amazonia show that old-growth forests have increased in carbon storage over recent decades, but the response of one-third of the world's tropical forests in Africa is largely unknown owing to an absence of spatially extensive observation networks. Here we report data from a ten-country network of long-term monitoring plots in African tropical forests. We find that across 79 plots (163 ha) above-ground carbon storage in live trees increased by 0.63 Mg C ha(-1) yr(-1) between 1968 and 2007 (95% confidence interval (CI), 0.22-0.94; mean interval, 1987-96). Extrapolation to unmeasured forest components (live roots, small trees, necromass) and scaling to the continent implies a total increase in carbon storage in African tropical forest trees of 0.34 Pg C yr(-1) (CI, 0.15-0.43). These reported changes in carbon storage are similar to those reported for Amazonian forests per unit area, providing evidence that increasing carbon storage in old-growth forests is a pan-tropical phenomenon. Indeed, combining all standardized inventory data from this study and from tropical America and Asia together yields a comparable figure of 0.49 Mg C ha(-1) yr(-1) (n = 156; 562 ha; CI, 0.29-0.66; mean interval, 1987-97). This indicates a carbon sink of 1.3 Pg C yr(-1) (CI, 0.8-1.6) across all tropical forests during recent decades. Taxon-specific analyses of African inventory and other data suggest that widespread changes in resource availability, such as increasing atmospheric carbon dioxide concentrations, may be the cause of the increase in carbon stocks, as some theory and models predict.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewis, Simon L -- Lopez-Gonzalez, Gabriela -- Sonke, Bonaventure -- Affum-Baffoe, Kofi -- Baker, Timothy R -- Ojo, Lucas O -- Phillips, Oliver L -- Reitsma, Jan M -- White, Lee -- Comiskey, James A -- Djuikouo K, Marie-Noel -- Ewango, Corneille E N -- Feldpausch, Ted R -- Hamilton, Alan C -- Gloor, Manuel -- Hart, Terese -- Hladik, Annette -- Lloyd, Jon -- Lovett, Jon C -- Makana, Jean-Remy -- Malhi, Yadvinder -- Mbago, Frank M -- Ndangalasi, Henry J -- Peacock, Julie -- Peh, Kelvin S-H -- Sheil, Douglas -- Sunderland, Terry -- Swaine, Michael D -- Taplin, James -- Taylor, David -- Thomas, Sean C -- Votere, Raymond -- Woll, Hannsjorg -- England -- Nature. 2009 Feb 19;457(7232):1003-6. doi: 10.1038/nature07771.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Earth and Biosphere Institute, School of Geography, University of Leeds, Leeds LS2 9JT, UK. s.l.lewis@leeds.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225523" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Atmosphere/chemistry ; Biomass ; Carbon/analysis/*metabolism ; Carbon Dioxide/analysis/metabolism ; Models, Biological ; Trees/anatomy & histology/chemistry/growth & development/*metabolism ; *Tropical Climate ; Wilderness ; Wood/analysis/chemistry
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    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2009-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foster, David A -- Darnell, James E Jr -- England -- Nature. 2009 Apr 9;458(7239):718. doi: 10.1038/458718a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19360078" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; History, 21st Century ; Japan ; Neoplasms/history/*virology ; Oncogenes ; Retroviridae ; United States ; Virology/*history
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    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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