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  • United States  (113)
  • Tumor Cells, Cultured  (49)
  • American Association for the Advancement of Science (AAAS)  (162)
  • 1995-1999  (162)
  • 1997  (162)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (162)
  • Springer  (5)
Years
  • 1995-1999  (162)
Year
  • 1
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    AIDS research chief bows out (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Oct 10;278(5336):218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9340767" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; History, 20th Century ; National Institutes of Health (U.S.)/*organization & administration ; Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    NCI reverses one expert panel, sides with another (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):27-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122702" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Breast Neoplasms/*prevention & control/radiography ; Consensus Development Conferences, NIH as Topic ; Female ; Humans ; *Mammography ; *Mass Screening ; Middle Aged ; *National Institutes of Health (U.S.) ; Randomized Controlled Trials as Topic ; Risk Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Human genome agreements (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorimer, B G -- New York, N.Y. -- Science. 1997 Jan 31;275(5300):601-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9019811" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Base Sequence ; DNA, Complementary/*genetics ; Databases, Factual ; *Genome, Human ; Humans ; Intellectual Property ; Publishing ; Research Support as Topic ; Sequence Analysis, DNA ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Key player: Kevin Kinsella. The industry's top showman (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):773.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036538" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/history/*organization & administration ; Genetics, Medical/history/*organization & administration ; Genome, Human ; History, 20th Century ; Humans ; Industry/history/organization & administration ; Molecular Biology/history/*organization & administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Evaluating biologics (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rall, J E -- New York, N.Y. -- Science. 1997 May 30;276(5317):1319-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9190671" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Evaluation ; National Institutes of Health (U.S.) ; Professional Competence ; Research Personnel ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Conditional mutator phenotypes in hMSH2-deficient tumor cell lines (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-05
    Description: Two human tumor cell lines that are deficient in the mismatch repair protein hMSH2 show little or no increase in mutation rate relative to that of a mismatch repair-proficient cell line when the cells are maintained in culture conditions allowing rapid growth. However, mutations accumulate at a high rate in these cells when they are maintained at high density. Thus the mutator phenotype of some mismatch repair-deficient cell lines is conditional and strongly depends on growth conditions. These observations have implications for tumor development because they suggest that mutations may accumulate in tumor cells when growth is limited.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richards, B -- Zhang, H -- Phear, G -- Meuth, M -- R01-CA-62244/CA/NCI NIH HHS/ -- T32-CA-09602/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1523-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncological Sciences, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9278518" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Count ; *Cell Division ; *DNA Repair ; DNA Replication ; *DNA-Binding Proteins ; Drug Resistance, Neoplasm ; Female ; Frameshift Mutation ; Humans ; Hypoxanthine Phosphoribosyltransferase/genetics ; Microsatellite Repeats ; MutS Homolog 2 Protein ; *Mutation ; Neoplasms/*genetics/pathology ; Ouabain/pharmacology ; Ovarian Neoplasms/genetics/pathology ; Phenotype ; Proto-Oncogene Proteins/genetics/*physiology ; Tumor Cells, Cultured ; Uterine Neoplasms/genetics/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Mammalian genome debate heats up (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1733.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122675" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animal Husbandry ; Animals ; Animals, Genetically Modified ; *Bioethics ; Cloning, Molecular ; Federal Government ; *Genetic Engineering ; Genetic Research ; Government Regulation ; Humans ; Public Policy ; Risk Assessment ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Sequencers call for faster data release (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 May 23;276(5316):1189-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182326" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Computer Communication Networks ; *Dna ; Europe ; Germany ; Humans ; *Information Dissemination ; Intellectual Property ; *Internationality ; *Patents as Topic ; Time Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Hughes network expands by a big leap (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 May 23;276(5316):1189.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182325" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics/organization & administration ; Financial Management ; Maryland ; Research Personnel ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    NIH plans peer-review overhaul (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 May 9;276(5314):888-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9163031" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; *Peer Review, Research/methods/standards ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 11
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    From science fiction to ethics quandary (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1997 Sep 19;277(5333):1753-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9324757" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Bioethics ; Federal Government ; *Genetic Engineering ; *Genetic Enhancement ; *Genetic Research ; *Genetic Therapy ; *Genetics, Medical ; Government Regulation ; Humans ; National Institutes of Health (U.S.) ; Social Change ; United States ; Wedge Argument
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    NCI plans attack on HIV resistance (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1997 May 2;276(5313):667.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157541" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy/virology ; Anti-HIV Agents/*pharmacology/therapeutic use ; Drug Resistance, Microbial ; HIV/*drug effects ; Humans ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 13
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    Lobbyists seek to reslice NIH's pie (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Apr 18;276(5311):344-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9139352" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; Lobbying ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 14
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    Sequence patents (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cullen, S E -- New York, N.Y. -- Science. 1997 Mar 28;275(5308):1861-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122683" target="_blank"〉PubMed〈/a〉
    Keywords: *Amino Acid Sequence ; *Base Sequence ; *Dna ; National Institutes of Health (U.S.)/*legislation & jurisprudence ; *Patents as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 15
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    U.S., Russia to study radiation effects (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Feb 21;275(5303):1062-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9054005" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Exposure ; Financing, Government ; Humans ; International Cooperation ; *Nuclear Reactors ; Occupational Exposure ; Plutonium/adverse effects ; *Radiation Dosage ; Radiation Effects ; Radiation Injuries/*etiology ; Radioactive Waste/*adverse effects ; Russia ; Strontium Radioisotopes/adverse effects ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 16
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    Gene tests get tested (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):782.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036543" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Centers for Medicare and Medicaid Services (U.S.) ; Confidentiality ; Federal Government ; Genetic Counseling ; Genetic Services ; Genetic Testing/*standards ; *Government ; *Government Regulation ; Humans ; Reproducibility of Results ; *Social Control, Formal ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 17
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    Shot in the arm for AIDS vaccine (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1997 Mar 14;275(5306):1573.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9072823" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Animals ; Humans ; National Institutes of Health (U.S.)/economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 18
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    UCSF case raises questions about grant idea ownership (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1430-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9304209" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Cutaneous ; Biomedical Research ; California ; Federal Government ; Government Regulation ; Heart/physiology ; Humans ; *Intellectual Property ; Nicotine/administration & dosage ; *Plagiarism ; *Research Support as Topic ; Smoking Cessation ; United States ; United States Office of Research Integrity ; *Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 19
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    How much pain for cardiac gain? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1997 May 30;276(5317):1324-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9190672" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Centers for Disease Control and Prevention (U.S.) ; Exercise/*physiology/psychology ; Female ; Guidelines as Topic ; Heart Diseases/epidemiology/*prevention & control ; Humans ; Male ; Middle Aged ; Risk Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 20
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    Furor over company deal roils AMA (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):26.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9340750" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic ; *American Medical Association/economics/organization & administration ; Contracts ; Equipment and Supplies ; *Ethics ; *Ethics, Business ; *Industry ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 21
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    Trafficking of matrix collagens through bone-resorbing osteoclasts (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-11
    Description: An intracellular pathway for proteins liberated from mineralized matrix during resorption was identified in osteoclasts. Analysis by confocal microscopy of sites of active bone resorption showed that released matrix proteins, including degraded type I collagen, were endocytosed along the ruffled border within the resorption compartment and transcytosed through the osteoclast to the basolateral membrane. Intracellular trafficking of degraded collagen, as typified by the resorbing osteoclast, may provide the cell with a regulatory mechanism for the control of tissue degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nesbitt, S A -- Horton, M A -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1997 Apr 11;276(5310):266-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone and Mineral Centre, Department of Medicine, University College London Medical School, University College London, London WIN 8AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9092478" target="_blank"〉PubMed〈/a〉
    Keywords: Bone Matrix/*metabolism ; *Bone Resorption ; Cell Membrane/metabolism/ultrastructure ; Collagen/*metabolism ; Dentin/metabolism ; *Endocytosis ; Humans ; Microscopy, Confocal ; Osteoclasts/*metabolism/ultrastructure ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    France distributes iodine near reactors (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, M -- New York, N.Y. -- Science. 1997 Mar 28;275(5308):1871-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122686" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Drug Utilization ; France ; Humans ; Iodine Radioisotopes/adverse effects ; Neoplasms, Radiation-Induced/etiology/*prevention & control ; Potassium Iodide/*administration & dosage ; *Power Plants ; *Radioactive Hazard Release ; Thyroid Neoplasms/etiology/*prevention & control ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Your complete Web guide to tumors (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrenstein, D -- New York, N.Y. -- Science. 1997 Aug 8;277(5327):762.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9273696" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chromosome Mapping ; *Computer Communication Networks ; *Databases, Factual ; *Genes ; Genome, Human ; Humans ; National Institutes of Health (U.S.) ; National Library of Medicine (U.S.) ; Neoplasms/*genetics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Broader oversight for research on humans? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 1997 Jan 31;275(5300):605.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644893" target="_blank"〉PubMed〈/a〉
    Keywords: Ethics Committees ; Ethics Committees, Research ; Federal Government ; Government ; *Government Regulation ; *Human Experimentation ; Humans ; Informed Consent ; Legislation as Topic ; Private Sector ; Public Sector ; *Social Control, Formal ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Tobacco control: the dramatic choice (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novelli, W D -- New York, N.Y. -- Science. 1997 Oct 10;278(5336):203.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9340761" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Advertising as Topic ; Child ; Health Policy ; Humans ; *Plants, Toxic ; Smoking/legislation & jurisprudence/*prevention & control ; Smoking Cessation ; *Tobacco ; Tobacco Industry/*legislation & jurisprudence ; Tobacco Smoke Pollution/prevention & control ; Tobacco, Smokeless ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-10
    Description: The caspase-3 (CPP32, apopain, YAMA) family of cysteinyl proteases has been implicated as key mediators of apoptosis in mammalian cells. Gelsolin was identified as a substrate for caspase-3 by screening the translation products of small complementary DNA pools for sensitivity to cleavage by caspase-3. Gelsolin was cleaved in vivo in a caspase-dependent manner in cells stimulated by Fas. Caspase-cleaved gelsolin severed actin filaments in vitro in a Ca2+-independent manner. Expression of the gelsolin cleavage product in multiple cell types caused the cells to round up, detach from the plate, and undergo nuclear fragmentation. Neutrophils isolated from mice lacking gelsolin had delayed onset of both blebbing and DNA fragmentation, following apoptosis induction, compared with wild-type neutrophils. Thus, cleaved gelsolin may be one physiological effector of morphologic change during apoptosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kothakota, S -- Azuma, T -- Reinhard, C -- Klippel, A -- Tang, J -- Chu, K -- McGarry, T J -- Kirschner, M W -- Koths, K -- Kwiatkowski, D J -- Williams, L T -- P01 HL48743/HL/NHLBI NIH HHS/ -- R01 HL54188/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 Oct 10;278(5336):294-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chiron Corporation, Emeryville, CA 94608, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9323209" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Antigens, CD95/physiology ; *Apoptosis ; Caspase 3 ; *Caspases ; Cell Line ; *Cell Size ; Cycloheximide/pharmacology ; Cysteine Endopeptidases/*metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Cytoskeleton/metabolism ; DNA Fragmentation ; Gelsolin/*metabolism ; Humans ; Mice ; Neutrophils/cytology/metabolism ; Recombinant Proteins/metabolism ; Transfection ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Corn genome initiative (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bevan, M W -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):885-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9281065" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*genetics ; European Union ; *Genome, Plant ; International Cooperation ; Japan ; *Sequence Analysis, DNA ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The civil commitment of sex offenders (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zonana, H -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1248-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Yale Law School, New Haven, CT 06519, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411753" target="_blank"〉PubMed〈/a〉
    Keywords: Antisocial Personality Disorder/psychology/therapy ; Commitment of Mentally Ill/*legislation & jurisprudence ; Humans ; *Mental Disorders/psychology/therapy ; Paraphilic Disorders/psychology/therapy ; Sex Offenses/*legislation & jurisprudence/prevention & control/psychology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 29
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    Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-21
    Description: The adenomatous polyposis coli (APC) tumor suppressor protein binds to beta-catenin, a protein recently shown to interact with Tcf and Lef transcription factors. The gene encoding hTcf-4, a Tcf family member that is expressed in colonic epithelium, was cloned and characterized. hTcf-4 transactivates transcription only when associated with beta-catenin. Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active, as measured by transcription of a Tcf reporter gene. Reintroduction of APC removed beta-catenin from hTcf-4 and abrogated the transcriptional transactivation. Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korinek, V -- Barker, N -- Morin, P J -- van Wichen, D -- de Weger, R -- Kinzler, K W -- Vogelstein, B -- Clevers, H -- CA57345/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1784-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9065401" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli Protein ; Amino Acid Sequence ; Animals ; Cell Line ; Cell Transformation, Neoplastic ; Cloning, Molecular ; Colon/metabolism ; Colonic Neoplasms/*genetics/metabolism ; Cytoskeletal Proteins/genetics/*metabolism ; Gene Expression Regulation, Neoplastic ; *Genes, APC ; Genes, Reporter ; Humans ; Intestinal Mucosa/metabolism ; Mice ; Molecular Sequence Data ; Signal Transduction ; TCF Transcription Factors ; *Trans-Activators ; Transcription Factor 7-Like 2 Protein ; Transcription Factors/chemistry/genetics/*metabolism ; *Transcriptional Activation ; Transfection ; Tumor Cells, Cultured ; beta Catenin
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Privatization of a journal (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boullin, J M -- New York, N.Y. -- Science. 1997 Jul 18;277(5324):297-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9518352" target="_blank"〉PubMed〈/a〉
    Keywords: Computer Communication Networks ; Costs and Cost Analysis ; Great Britain ; National Institutes of Health (U.S.) ; *Neoplasms ; *Periodicals as Topic/economics ; Private Sector ; *Publishing/economics ; United States ; Universities
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Cross-language analysis of phonetic units in language addressed to infants (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-01
    Description: In the early months of life, infants acquire information about the phonetic properties of their native language simply by listening to adults speak. The acoustic properties of phonetic units in language input to young infants in the United States, Russia, and Sweden were examined. In all three countries, mothers addressing their infants produced acoustically more extreme vowels than they did when addressing adults, resulting in a "stretching" of vowel space. The findings show that language input to infants provides exceptionally well-specified information about the linguistic units that form the building blocks for words.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuhl, P K -- Andruski, J E -- Chistovich, I A -- Chistovich, L A -- Kozhevnikova, E V -- Ryskina, V L -- Stolyarova, E I -- Sundberg, U -- Lacerda, F -- DC 00520/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 1997 Aug 1;277(5326):684-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Speech and Hearing Sciences, University of Washington, Box 357920, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9235890" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Female ; Humans ; Infant ; *Language Development ; Mothers ; *Phonetics ; Russia ; Speech Acoustics ; *Speech Perception ; Sweden ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Microbiology's scarred revolutionary (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, V -- New York, N.Y. -- Science. 1997 May 2;276(5313):699-702.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157549" target="_blank"〉PubMed〈/a〉
    Keywords: Archaea/*classification/genetics/physiology ; Bacteria/*classification/genetics ; Base Sequence ; Biological Evolution ; History, 20th Century ; Origin of Life ; *Phylogeny ; RNA, Bacterial/genetics ; RNA, Ribosomal/genetics ; Sequence Analysis, RNA ; Temperature ; United States
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  • 33
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    Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-18
    Description: Most cases of early-onset familial Alzheimer's disease (FAD) are caused by mutations in the genes encoding the presenilin 1 (PS1) and PS2 proteins, both of which undergo regulated endoproteolytic processing. During apoptosis, PS1 and PS2 were shown to be cleaved at sites distal to their normal cleavage sites by a caspase-3 family protease. In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, T W -- Pettingell, W H -- Jung, Y K -- Kovacs, D M -- Tanzi, R E -- New York, N.Y. -- Science. 1997 Jul 18;277(5324):373-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9219695" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*genetics/metabolism/pathology ; Amino Acid Chloromethyl Ketones/pharmacology ; Amino Acid Substitution ; Animals ; *Apoptosis ; Caspase 3 ; *Caspases ; Cysteine Endopeptidases/*metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Enzyme Activation ; Etoposide/pharmacology ; Membrane Proteins/chemistry/genetics/*metabolism ; Mutation ; Oligopeptides/pharmacology ; Phosphorylation ; Presenilin-1 ; Presenilin-2 ; Rats ; Staurosporine/pharmacology ; Tumor Cells, Cultured
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  • 34
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    Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-08
    Description: TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheridan, J P -- Marsters, S A -- Pitti, R M -- Gurney, A -- Skubatch, M -- Baldwin, D -- Ramakrishnan, L -- Gray, C L -- Baker, K -- Wood, W I -- Goddard, A D -- Godowski, P -- Ashkenazi, A -- New York, N.Y. -- Science. 1997 Aug 8;277(5327):818-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Oncology, Genentech, South San Francisco, CA 94080-4918, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9242611" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; *Apoptosis ; Apoptosis Regulatory Proteins ; Cell Membrane/metabolism ; Cells, Cultured ; GPI-Linked Proteins ; Glycosylphosphatidylinositols/metabolism ; HeLa Cells ; Humans ; Ligands ; Membrane Glycoproteins/*metabolism ; Molecular Sequence Data ; NF-kappa B/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism ; Signal Transduction ; TNF-Related Apoptosis-Inducing Ligand ; Transfection ; Tumor Cells, Cultured ; Tumor Necrosis Factor Decoy Receptors ; Tumor Necrosis Factor-alpha/*metabolism
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    A range of research-based pharmacotherapies for addiction (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-06
    Description: Modern approaches to the treatment of addiction have been influenced by several important factors. These include advances in our understanding of the nature of addiction based on longitudinal studies, and progress in elucidating the biological underpinnings of addictive behavior. In addition, changes in the system for delivery of services have begun to shape the way that addiction is treated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, C P -- P60-05186/PHS HHS/ -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):66-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Pennsylvania VA Medical Center, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA. obrien@research.trc.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9311929" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/drug therapy ; Animals ; Behavior, Addictive ; Clinical Trials as Topic ; Delivery of Health Care ; Humans ; Narcotic Antagonists/pharmacology/therapeutic use ; Receptors, Opioid/agonists ; Recurrence ; Substance Withdrawal Syndrome/drug therapy ; Substance-Related Disorders/*drug therapy/prevention & control/psychology ; United States ; Vaccines
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  • 36
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    The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-18
    Description: Engagement of antigen and immunoglobulin receptors on hematopoietic cells is directly coupled to activation of nonreceptor protein tyrosine kinases (PTKs) that then phosphorylate critical intracellular substrates. In mast cells stimulated through the FcvarepsilonRI receptor, activation of several PTKs including Syk leads to degranulation and release of such mediators of the allergic response as histamine and serotonin. Regulation of Syk function occurred through interaction with the Cbl protein, itself a PTK substrate in this system. Overexpression of Cbl led to inhibition of Syk and suppression of serotonin release from mast cells, demonstrating its ability to inhibit a nonreceptor tyrosine kinase. Complex adaptor proteins such as Cbl can directly regulate the functions of the proteins they bind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ota, Y -- Samelson, L E -- New York, N.Y. -- Science. 1997 Apr 18;276(5311):418-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-5430, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9103201" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Degranulation ; Enzyme Precursors/antagonists & inhibitors/*metabolism ; Genetic Vectors ; Intracellular Signaling Peptides and Proteins ; Mast Cells/*metabolism ; Mutation ; Phosphorylation ; Phosphotyrosine/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors/*metabolism ; Proto-Oncogene Proteins/chemistry/genetics/*metabolism ; Proto-Oncogene Proteins c-cbl ; Rats ; Receptors, IgE/metabolism ; Receptors, IgG/metabolism ; Recombinant Proteins/metabolism ; Serotonin/metabolism ; Signal Transduction ; Tumor Cells, Cultured ; *Ubiquitin-Protein Ligases ; Vaccinia virus
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  • 37
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    Modulation of hepatic gene expression by hepatocyte nuclear factor 1 (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4-dependent genes that lack HNF-1 binding sites in their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2, the main activation domain of HNF-4. The dual functions of gene activation and repression suggest that HNF-1 is a global regulator of the transcriptional network involved in the maintenance of hepatocyte-specific phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ktistaki, E -- Talianidis, I -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):109-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Post Office Box 1527, 711 10 Heraklion, Crete, Greece.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204893" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Binding Sites ; COS Cells ; *DNA-Binding Proteins ; *Gene Expression Regulation ; Hepatocyte Nuclear Factor 1 ; Hepatocyte Nuclear Factor 1-alpha ; Hepatocyte Nuclear Factor 1-beta ; Hepatocyte Nuclear Factor 4 ; Humans ; Liver/cytology/*metabolism ; Nuclear Proteins/genetics/metabolism ; Phosphoproteins/genetics/metabolism ; Promoter Regions, Genetic ; RNA, Messenger/genetics/metabolism ; Recombinant Fusion Proteins/metabolism ; Transcription Factors/*genetics/*metabolism ; Transcriptional Activation ; Tumor Cells, Cultured
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  • 38
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    Privatization of a journal (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chappell, J -- New York, N.Y. -- Science. 1997 Jul 18;277(5324):298-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9518353" target="_blank"〉PubMed〈/a〉
    Keywords: Copyright ; Costs and Cost Analysis ; Great Britain ; National Institutes of Health (U.S.) ; *Neoplasms ; *Periodicals as Topic/economics/legislation & jurisprudence ; Private Sector ; *Publishing/economics/legislation & jurisprudence ; United States ; Universities
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  • 39
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    Proposed air pollutant standards (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abelson, P H -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9229761" target="_blank"〉PubMed〈/a〉
    Keywords: Air/*standards ; Air Pollutants/*analysis ; Environmental Monitoring ; Humans ; Maximum Allowable Concentration ; Ozone/*analysis ; United States ; United States Environmental Protection Agency
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  • 40
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    Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pleskoff, O -- Treboute, C -- Brelot, A -- Heveker, N -- Seman, M -- Alizon, M -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1874-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Inserm U.332, Institut Cochin de Genetique Moleculaire, 22 rue Mechain, 75014 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188536" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS-Related Opportunistic Infections/virology ; Amino Acid Sequence ; Cell Fusion ; Chemokines ; Coculture Techniques ; Cytomegalovirus/*genetics/physiology ; Cytomegalovirus Infections/virology ; Giant Cells ; HIV Infections/virology ; HIV-1/*physiology ; HIV-2/*physiology ; HeLa Cells ; Humans ; Membrane Proteins/physiology ; Molecular Sequence Data ; Receptors, CCR2 ; Receptors, CCR5 ; Receptors, CXCR4 ; *Receptors, Chemokine ; Receptors, Cytokine/genetics/*physiology ; Receptors, HIV/genetics/*physiology ; Transfection ; Tumor Cells, Cultured ; Viral Proteins/genetics/*physiology
    Print ISSN: 0036-8075
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    Companies rush to patent DNA (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):780-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036542" target="_blank"〉PubMed〈/a〉
    Keywords: *Dna ; DNA, Complementary ; Databases, Nucleic Acid ; Federal Government ; *Genes ; Genetic Research ; *Genome, Human ; Humans ; Information Dissemination ; National Institutes of Health (U.S.)/legislation & jurisprudence ; *Patents as Topic ; United States
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  • 42
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    Cystic fibrosis transmembrane conductance regulator and adenosine triphosphate (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abraham, E H -- Okunieff, P -- Scala, S -- Vos, P -- Oosterveld, M J -- Chen, A Y -- Shrivastav, B -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1324-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064787" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/metabolism ; Adenosine Triphosphate/*metabolism ; Biological Transport ; Cell Membrane/*metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism ; Humans ; P-Glycoprotein/metabolism ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The breast-screening brawl (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Feb 21;275(5303):1056-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9054004" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Aged ; Breast Neoplasms/*mortality/prevention & control/radiography ; Consensus Development Conferences, NIH as Topic ; Female ; Humans ; *Mammography/statistics & numerical data ; *Mass Screening/statistics & numerical data ; Middle Aged ; Randomized Controlled Trials as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Corn genome pops out of the pack (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):1960-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9221492" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics ; DNA, Complementary/genetics ; DNA, Plant/genetics ; Databases, Factual ; Financing, Government ; Gene Expression ; *Genome, Plant ; International Cooperation ; Oryza/genetics ; Research Support as Topic ; Sequence Analysis, DNA ; United States ; Zea mays/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 45
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    SV40 and human cancer (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayflick, L -- New York, N.Y. -- Science. 1997 Apr 18;276(5311):337-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9139350" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; *Cell Transformation, Neoplastic ; *Cell Transformation, Viral ; Haplorhini ; Humans ; Poliovirus/growth & development ; *Poliovirus Vaccine, Inactivated ; Simian virus 40/*pathogenicity ; United States ; United States Food and Drug Administration ; Virus Cultivation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 46
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    A mammalian telomerase-associated protein (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: The telomerase ribonucleoprotein catalyzes the addition of new telomeres onto chromosome ends. A gene encoding a mammalian telomerase homolog called TP1 (telomerase-associated protein 1) was identified and cloned. TP1 exhibited extensive amino acid similarity to the Tetrahymena telomerase protein p80 and was shown to interact specifically with mammalian telomerase RNA. Antiserum to TP1 immunoprecipitated telomerase activity from cell extracts, suggesting that TP1 is associated with telomerase in vivo. The identification of TP1 suggests that telomerase-associated proteins are conserved from ciliates to humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrington, L -- McPhail, T -- Mar, V -- Zhou, W -- Oulton, R -- Bass, M B -- Arruda, I -- Robinson, M O -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):973-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Arruda, Ontario Cancer Institute-Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020079" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Blotting, Northern ; Carrier Proteins/*chemistry/genetics/immunology/*metabolism ; Cell Line ; Cloning, Molecular ; DNA, Complementary/genetics ; Humans ; Mice ; Molecular Sequence Data ; Precipitin Tests ; RNA/*metabolism ; RNA, Messenger/genetics/metabolism ; Sequence Homology, Amino Acid ; Telomerase/*chemistry/genetics/metabolism ; Tetrahymena/chemistry/genetics ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The rise and fall of Project SIDA (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1565-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411779" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/epidemiology/immunology/therapy ; Belgium ; Budgets ; Centers for Disease Control and Prevention (U.S.) ; Democratic Republic of the Congo ; Humans ; International Cooperation ; National Institutes of Health (U.S.) ; *Research ; Research Support as Topic ; United States
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    India applauds U.S. patent reversal (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- Bagla, P -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1429.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9304208" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Curcumin/*therapeutic use ; Humans ; India ; *Patents as Topic ; *Plants, Medicinal ; United States ; Wound Healing
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    Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-12
    Description: Gangliosides participate in development and tissue differentiation. Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation. CD95-induced GD3 accumulation depended on integral receptor "death domains" and on activation of a family of cysteine proteases called caspases. Cell-permeating ceramides, which are potent inducers of apoptosis, also triggered GD3 synthesis. GD3 disrupted mitochondrial transmembrane potential (DeltaPsim), and induced apoptosis, in a caspase-independent fashion. Transient overexpression of the GD3 synthase gene directly triggered apoptosis. Pharmacological inhibition of GD3 synthesis and exposure to GD3 synthase antisense oligodeoxynucleotides prevented CD95-induced apoptosis. Thus, GD3 ganglioside mediates the propagation of CD95-generated apoptotic signals in hematopoietic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Maria, R -- Lenti, L -- Malisan, F -- d'Agostino, F -- Tomassini, B -- Zeuner, A -- Rippo, M R -- Testi, R -- New York, N.Y. -- Science. 1997 Sep 12;277(5332):1652-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata," 00133 Rome, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9287216" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, CD95/metabolism/*physiology ; *Apoptosis ; Ceramides/pharmacology/*physiology ; Cysteine Endopeptidases/metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Enzyme Inhibitors/pharmacology ; Gangliosides/biosynthesis/*metabolism/pharmacology ; Golgi Apparatus/metabolism ; Humans ; Membrane Potentials ; Mitochondria/physiology ; Morpholines/pharmacology ; Oligonucleotides, Antisense/pharmacology ; Sialyltransferases/genetics/metabolism ; Signal Transduction ; Transfection ; Tumor Cells, Cultured
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    Genetic information and the workplace: legislative approaches and policy changes (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rothenberg, K -- Fuller, B -- Rothstein, M -- Duster, T -- Ellis Kahn, M J -- Cunningham, R -- Fine, B -- Hudson, K -- King, M C -- Murphy, P -- Swergold, G -- Collins, F -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1755-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Law and Health Care Program, University of Maryland School of Law, 500 West Baltimore Street, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122681" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; Disclosure ; Employment/*legislation & jurisprudence ; Federal Government ; Genetic Diseases, Inborn ; *Genetic Privacy ; *Genetic Testing ; *Genetics, Medical ; *Government Regulation ; Humans ; Insurance Selection Bias ; Insurance, Health/legislation & jurisprudence ; *Prejudice ; *Public Policy ; United States
    Print ISSN: 0036-8075
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    AIDS: a justifiable share (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Apr 18;276(5311):345.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9139353" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; *Budgets ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
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    Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ colon adenocarcinomas examined were found to have frameshift mutations in a tract of eight deoxyguanosines [(G)8] within BAX, a gene that promotes apoptosis. These mutations were absent in MMP- tumors and were significantly less frequent in (G)8 repeats from other genes. Frameshift mutations were present in both BAX alleles in some MMP+ colon tumor cell lines and in primary tumors. These results suggest that inactivating BAX mutations are selected for during the progression of colorectal MMP+ tumors and that the wild-type BAX gene plays a suppressor role in a p53-independent pathway for colorectal carcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rampino, N -- Yamamoto, H -- Ionov, Y -- Li, Y -- Sawai, H -- Reed, J C -- Perucho, M -- CA38579/CA/NCI NIH HHS/ -- CA63585/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):967-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Burnham Institute, La Jolla Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020077" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*genetics ; Alleles ; Apoptosis ; Base Sequence ; Colonic Neoplasms/*genetics ; *Frameshift Mutation ; Gene Expression ; *Genes, Tumor Suppressor ; Humans ; Microsatellite Repeats/*genetics ; Molecular Sequence Data ; Mutation ; Phenotype ; Polymerase Chain Reaction ; Proto-Oncogene Proteins/*genetics ; *Proto-Oncogene Proteins c-bcl-2 ; Sequence Deletion ; Tumor Cells, Cultured ; bcl-2-Associated X Protein
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    The costs of animal research: origins and options (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cork, L C -- Clarkson, T B -- Jacoby, R O -- Gaertner, D J -- Leary, S L -- Linn, J M -- Pakes, S P -- Ringler, D H -- Strandberg, J D -- Swindle, M M -- New York, N.Y. -- Science. 1997 May 2;276(5313):758-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157554" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Welfare ; Animals ; *Animals, Laboratory ; Costs and Cost Analysis ; Financing, Government ; Laboratory Animal Science/*economics/education ; National Institutes of Health (U.S.)/economics ; Research/*economics ; *Research Support as Topic ; United States ; Veterinary Medicine/economics
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    The mouse that prompted a roar (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9229765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteriophage P1/genetics ; DNA, Complementary ; Gene Expression ; *Gene Targeting ; Genetic Engineering/*methods ; Integrases/genetics ; Mice ; *Mice, Transgenic ; National Institutes of Health (U.S.) ; *Patents as Topic ; Polymerase Chain Reaction ; United States ; *Viral Proteins
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    Last-minute deal give NIH 7.1% raise (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411744" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; Human Genome Project ; Humans ; National Institutes of Health (U.S.)/*economics ; Parkinson Disease ; Research Support as Topic ; United States
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  • 56
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    A bitter battle over insulin gene (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Aug 22;277(5329):1028-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9289846" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; California ; *Cloning, Molecular ; DNA, Recombinant ; Drug Industry ; *Genetic Research ; *Genetic Vectors ; Guideline Adherence/legislation & jurisprudence ; Humans ; Insulin/*genetics ; National Institutes of Health (U.S.) ; *Patents as Topic ; *Plasmids ; Rats ; Recombinant Proteins ; Scientific Misconduct/*legislation & jurisprudence ; United States ; Universities
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    Chimp retirement plan proposed (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1997 Jul 25;277(5325):471.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9254416" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome ; *Animal Experimentation ; *Animal Welfare ; Animals ; *Animals, Laboratory ; Costs and Cost Analysis ; Federal Government ; Housing, Animal ; National Institutes of Health (U.S.) ; *Pan troglodytes ; Research ; United States
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    Molecules give new insights into deadliest brain cancers (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1226.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411748" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brevican ; Carrier Proteins/genetics/*physiology ; Chloride Channels/*physiology ; Chondroitin Sulfate Proteoglycans ; Glioma/*metabolism/*pathology/therapy ; Humans ; Lectins, C-Type ; Neoplasm Invasiveness ; Nerve Tissue Proteins/genetics/*physiology ; Neuroglia/metabolism ; Rats ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-21
    Description: Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical activities associated with the APC protein is down-regulation of transcriptional activation mediated by beta-catenin and T cell transcription factor 4 (Tcf-4). The protein products of mutant APC genes present in colorectal tumors were found to be defective in this activity. Furthermore, colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites. These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morin, P J -- Sparks, A B -- Korinek, V -- Barker, N -- Clevers, H -- Vogelstein, B -- Kinzler, K W -- CA57345/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1787-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9065402" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli Protein ; Colonic Neoplasms/*genetics/metabolism ; Cytoskeletal Proteins/*genetics/*metabolism ; Gene Expression Regulation, Neoplastic ; *Genes, APC ; Genes, Reporter ; Germ-Line Mutation ; Humans ; Mutation ; Phosphorylation ; Signal Transduction ; TCF Transcription Factors ; *Trans-Activators ; Transcription Factor 7-Like 2 Protein ; Transcription Factors/*metabolism ; *Transcription, Genetic ; Transfection ; Tumor Cells, Cultured ; beta Catenin
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    South wants place at table in new collaborative effort (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bagla, P -- New York, N.Y. -- Science. 1997 Sep 26;277(5334):1918-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9333942" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Asia, Western ; Budgets ; Developing Countries ; Europe ; Humans ; *International Cooperation ; *Malaria ; National Institutes of Health (U.S.) ; *Research ; Research Support as Topic ; United States ; World Health Organization
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Research and regulation at FDA (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berkower, I -- New York, N.Y. -- Science. 1997 Apr 11;276(5310):183-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9132937" target="_blank"〉PubMed〈/a〉
    Keywords: Drug Approval ; *Research ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    ORI's self-assessment: a batting average of .920? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedly, J -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1255.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064778" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; Federal Government ; *Government Regulation ; *Scientific Misconduct ; United States ; *United States Office of Research Integrity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 63
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    Privatization of a journal (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Safran, C -- New York, N.Y. -- Science. 1997 Jul 18;277(5324):299-300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9518354" target="_blank"〉PubMed〈/a〉
    Keywords: Copyright/*legislation & jurisprudence ; Great Britain ; National Institutes of Health (U.S.) ; Periodicals as Topic/*legislation & jurisprudence ; Private Sector ; Publishing/*legislation & jurisprudence ; United States ; Universities
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    No misconduct in 'gay gene' study (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1251.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644902" target="_blank"〉PubMed〈/a〉
    Keywords: Federal Government ; Genetic Research ; Genetics ; *Genetics, Behavioral ; Government ; *Homosexuality ; Humans ; Men ; Public Policy ; Research Personnel ; *Scientific Misconduct ; United States ; *United States Office of Research Integrity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Consensus on African research projects (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, N -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1393-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411759" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; Antimalarials/therapeutic use ; Genome, Protozoan ; Humans ; *International Cooperation ; *Malaria/drug therapy/parasitology ; National Institutes of Health (U.S.) ; Plasmodium falciparum/genetics ; *Research ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Curing rat glioblastoma: immunotherapy or graft rejection? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beutler, A S -- Banck, M S -- Aguzzi, A -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):20-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Glioblastoma/*immunology/*therapy ; *Graft Rejection ; Histocompatibility Antigens/*immunology ; Insulin-Like Growth Factor I/*genetics ; Major Histocompatibility Complex ; Neoplasm Transplantation ; RNA, Antisense/*therapeutic use ; Rats ; Transplantation, Homologous ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Synergy paper questioned at toxicology meeting (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1997 Mar 28;275(5308):1879.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122688" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlordan/metabolism/pharmacology ; Dieldrin/metabolism/pharmacology ; Drug Synergism ; Endosulfan/metabolism/pharmacology ; Estrogens, Non-Steroidal/metabolism/*pharmacology ; Female ; Humans ; Insecticides/metabolism/*pharmacology ; Receptors, Estrogen/*drug effects/metabolism ; Reproducibility of Results ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The 'Gallo case': Popovic strikes back (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):920-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9053992" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; Compensation and Redress ; Federal Government ; *Government Regulation ; History, 20th Century ; Scientific Misconduct/*legislation & jurisprudence ; United States ; United States Office of Research Integrity/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Global initiative takes shape slowly (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallagher, R -- New York, N.Y. -- Science. 1997 Jul 18;277(5324):309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9518357" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Antimalarials ; Drug Industry ; Europe ; Humans ; *International Cooperation ; *Malaria/drug therapy ; National Institutes of Health (U.S.) ; *Peer Review, Research ; *Research Support as Topic ; United Nations ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    AIDS: the process of discovery (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, R -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):141; author reply 142.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8999538" target="_blank"〉PubMed〈/a〉
    Keywords: Chemokines/*physiology ; HIV/*physiology ; Humans ; Italy ; National Institutes of Health (U.S.) ; Receptors, Cytokine/*physiology ; Receptors, HIV/*physiology ; United States
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    Xenotransplant risks to be aired at forum (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):743.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644894" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attitude ; Communicable Diseases ; Federal Government ; Government ; Guidelines as Topic ; Humans ; *National Institutes of Health (U.S.) ; *Organ Transplantation ; Primates ; Public Health ; *Public Policy ; Research Personnel ; Risk ; Swine ; Transplantation ; *Transplantation, Heterologous ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
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  • 72
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    Bioethics panel: big agenda, small budget (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 1997 Jan 24;275(5299):467.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644892" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Federal Government ; *Financing, Government ; Genetic Research ; Genetics ; Government ; Human Experimentation ; *Public Policy ; United States
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    Continuous innovation in health (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shine, K I -- New York, N.Y. -- Science. 1997 Jan 3;275(5296):9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8999537" target="_blank"〉PubMed〈/a〉
    Keywords: *Academic Medical Centers/economics/organization & administration ; Budgets ; National Institutes of Health (U.S.)/economics ; *Research/economics ; *Research Support as Topic ; United States
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    $1.6 million fraud award overturned (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1997 Jan 31;275(5300):610.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9019815" target="_blank"〉PubMed〈/a〉
    Keywords: Alabama ; Cytomegalovirus Infections ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; National Institutes of Health (U.S.) ; Research Support as Topic ; Scientific Misconduct/*legislation & jurisprudence ; United States ; Universities/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-10
    Description: Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boshoff, C -- Endo, Y -- Collins, P D -- Takeuchi, Y -- Reeves, J D -- Schweickart, V L -- Siani, M A -- Sasaki, T -- Williams, T J -- Gray, P W -- Moore, P S -- Chang, Y -- Weiss, R A -- CA 67391/CA/NCI NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1997 Oct 10;278(5336):290-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9323208" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CD4-Positive T-Lymphocytes/virology ; Chemokines/genetics/metabolism/pharmacology/*physiology ; Chemotaxis, Leukocyte ; Chick Embryo ; Eosinophils/physiology ; HIV-1/*physiology ; Herpesvirus 8, Human/*genetics/physiology ; Humans ; Leukocytes, Mononuclear/virology ; Macrophage Inflammatory Proteins/genetics/metabolism/pharmacology/*physiology ; Neovascularization, Pathologic/*etiology ; Neutrophils/physiology ; Receptors, CCR3 ; *Receptors, Chemokine ; Receptors, Cytokine/agonists/metabolism ; Receptors, HIV/metabolism ; Tumor Cells, Cultured ; *Viral Proteins ; Virus Replication
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    A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-29
    Description: Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact with the transporter associated with antigen processing (TAP) through a molecule called tapasin. The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene. It is a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Up to four MHC class I-tapasin complexes were found to bind to each TAP molecule. Expression of tapasin in a negative mutant human cell line (220) restored class I-TAP association and normal class I cell surface expression. Tapasin expression also corrected the defective recognition of virus-infected 220 cells by class I-restricted cytotoxic T cells, establishing a critical functional role for tapasin in MHC class I-restricted antigen processing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ortmann, B -- Copeman, J -- Lehner, P J -- Sadasivan, B -- Herberg, J A -- Grandea, A G -- Riddell, S R -- Tampe, R -- Spies, T -- Trowsdale, J -- Cresswell, P -- AI30581/AI/NIAID NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1997 Aug 29;277(5330):1306-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9271576" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/*metabolism ; Amino Acid Sequence ; Antigen Presentation ; Antiporters/chemistry/genetics/*metabolism ; Calcium-Binding Proteins/metabolism ; Calreticulin ; Cell Line ; Cell Line, Transformed ; Chromosome Mapping ; Chromosomes, Human, Pair 6 ; Cloning, Molecular ; Dimerization ; Endoplasmic Reticulum/metabolism ; Genetic Linkage ; HLA Antigens/*metabolism ; Histocompatibility Antigens Class I/*metabolism ; Humans ; Immunoglobulin G/chemistry ; Immunoglobulins/chemistry/genetics/*metabolism ; Major Histocompatibility Complex/genetics ; Membrane Transport Proteins ; Molecular Sequence Data ; Ribonucleoproteins/metabolism ; Sequence Homology, Amino Acid ; T-Lymphocytes, Cytotoxic ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Brain, drugs and society (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gazzaniga, M S -- New York, N.Y. -- Science. 1997 Jan 24;275(5299):459.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9019800" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Cognition ; Drug and Narcotic Control/economics ; Financing, Government ; Humans ; *Research Support as Topic ; Substance-Related Disorders/economics/*etiology ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    An antagonist decoy receptor and a death domain-containing receptor for TRAIL (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-08
    Description: TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types. An antagonist decoy receptor (designated as TRID for TRAIL receptor without an intracellular domain) that may explain the resistant phenotype of normal tissues was identified. TRID is a distinct gene product with an extracellular TRAIL-binding domain and a transmembrane domain but no intracellular signaling domain. TRID transcripts were detected in many normal human tissues but not in most cancer cell lines examined. Ectopic expression of TRID protected mammalian cells from TRAIL-induced apoptosis, which is consistent with a protective role. Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pan, G -- Ni, J -- Wei, Y F -- Yu, G -- Gentz, R -- Dixit, V M -- ES08111/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1997 Aug 8;277(5327):815-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9242610" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; *Apoptosis ; Apoptosis Regulatory Proteins ; Caspase 10 ; Caspase 8 ; Caspase 9 ; *Caspases ; Cell Line, Transformed ; Cysteine Endopeptidases/metabolism ; GPI-Linked Proteins ; HeLa Cells ; Humans ; Ligands ; Membrane Glycoproteins/*metabolism ; Molecular Sequence Data ; Protein Sorting Signals ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism ; Sequence Alignment ; Signal Transduction ; TNF-Related Apoptosis-Inducing Ligand ; Transfection ; Tumor Cells, Cultured ; Tumor Necrosis Factor Decoy Receptors ; Tumor Necrosis Factor-alpha/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The receptor for the cytotoxic ligand TRAIL (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-04
    Description: TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic "death domain" capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pan, G -- O'Rourke, K -- Chinnaiyan, A M -- Gentz, R -- Ebner, R -- Ni, J -- Dixit, V M -- DAMD17-96-1-6085/DA/NIDA NIH HHS/ -- ES08111/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):111-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9082980" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptor Proteins, Signal Transducing ; Amino Acid Sequence ; *Apoptosis ; Apoptosis Regulatory Proteins ; Carrier Proteins/metabolism ; Cell Line ; Fas-Associated Death Domain Protein ; Humans ; Ligands ; Membrane Glycoproteins/*metabolism ; Molecular Sequence Data ; NF-kappa B/metabolism ; Proteins/metabolism ; RNA, Messenger/genetics/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; TNF Receptor-Associated Factor 1 ; TNF-Related Apoptosis-Inducing Ligand ; Transfection ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 80
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    Beta-catenin as oncogene: the smoking gun (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peifer, M -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1752-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. peifer@unc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122680" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli Protein ; Animals ; Apoptosis ; Cell Division ; Cell Movement ; Colon/cytology/metabolism ; Colonic Neoplasms/*genetics/metabolism ; Cytoskeletal Proteins/*genetics/*metabolism ; DNA-Binding Proteins/metabolism ; *Drosophila Proteins ; Gene Expression Regulation, Neoplastic ; Genes, APC ; Humans ; Insect Proteins/metabolism ; Intestinal Mucosa/cytology/metabolism ; Lymphoid Enhancer-Binding Factor 1 ; Melanoma/*genetics/metabolism ; Mutation ; *Oncogenes ; *Repressor Proteins ; Signal Transduction ; *Trans-Activators ; Transcription Factors/metabolism ; Tumor Cells, Cultured ; beta Catenin
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 81
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    Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: The mechanisms responsible for thyrocyte destruction in Hashimoto's thyroiditis (HT) are poorly understood. Thyrocytes from HT glands, but not from nonautoimmune thyroids, expressed Fas. Interleukin-1beta (IL-1beta), abundantly produced in HT glands, induced Fas expression in normal thyrocytes, and cross-linking of Fas resulted in massive thyrocyte apoptosis. The ligand for Fas (FasL) was shown to be constitutively expressed both in normal and HT thyrocytes and was able to kill Fas-sensitive targets. Exposure to IL-1beta induced thyrocyte apoptosis, which was prevented by antibodies that block Fas, suggesting that IL-1beta-induced Fas expression serves as a limiting factor for thyrocyte destruction. Thus, Fas-FasL interactions among HT thyrocytes may contribute to clinical hypothyroidism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giordano, C -- Stassi, G -- De Maria, R -- Todaro, M -- Richiusa, P -- Papoff, G -- Ruberti, G -- Bagnasco, M -- Testi, R -- Galluzzo, A -- A.066/Telethon/Italy -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):960-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology, Endocrinology Section, Institute of Clinica Medica, University of Palermo, Palermo, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020075" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/immunology ; Antigens, CD95/biosynthesis/immunology/*metabolism ; *Apoptosis ; Cells, Cultured ; Cytokines/pharmacology ; Fas Ligand Protein ; Humans ; Immunoenzyme Techniques ; Interleukin-1/pharmacology ; Membrane Glycoproteins/biosynthesis/*metabolism ; Nucleic Acid Synthesis Inhibitors/pharmacology ; Polymerase Chain Reaction ; Protein Synthesis Inhibitors/pharmacology ; RNA, Messenger/genetics/metabolism ; Recombinant Proteins/pharmacology ; Thyroid Gland/*metabolism/pathology ; Thyroiditis, Autoimmune/*etiology/metabolism/pathology ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 82
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    Corn genome initiative (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sorrells, M E -- Anderson, O D -- Baenziger, P S -- Cook, R J -- Cregan, P B -- Dubcovsky, J -- Dvorak, J -- Gill, B S -- Hart, G E -- Hayes, P M -- Herman, E M -- Kleinhofs, A -- Line, R F -- Qualset, C O -- McGuire, P E -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):884-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9281064" target="_blank"〉PubMed〈/a〉
    Keywords: Edible Grain/*genetics ; Financing, Government ; *Genome, Plant ; *Research Support as Topic ; United States ; United States Department of Agriculture ; Zea mays/*genetics
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  • 83
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    Review staff at FDA (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldhammer, A -- New York, N.Y. -- Science. 1997 May 2;276(5313):661.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157539" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Approval ; Fees and Charges ; *Personnel Staffing and Scheduling ; Research ; United States ; United States Food and Drug Administration/economics/*organization & ; administration
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  • 84
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    Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-23
    Description: Inositol hexakisphosphate (InsP6), the dominant inositol phosphate in insulin-secreting pancreatic beta cells, inhibited the serine-threonine protein phosphatases type 1, type 2A, and type 3 in a concentration-dependent manner. The activity of voltage-gated L-type calcium channels is increased in cells treated with inhibitors of serine-threonine protein phosphatases. Thus, the increased calcium channel activity obtained in the presence of InsP6 might result from the inhibition of phosphatase activity. Glucose elicited a transient increase in InsP6 concentration, which indicates that this inositol polyphosphate may modulate calcium influx over the plasma membrane and serve as a signal in the pancreatic beta cell stimulus-secretion coupling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larsson, O -- Barker, C J -- Sjoholm, A -- Carlqvist, H -- Michell, R H -- Bertorello, A -- Nilsson, T -- Honkanen, R E -- Mayr, G W -- Zwiller, J -- Berggren, P O -- New York, N.Y. -- Science. 1997 Oct 17;278(5337):471-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institute, S-171 76 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9334307" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channels/drug effects/*metabolism ; Cell Membrane/metabolism ; Cricetinae ; Dose-Response Relationship, Drug ; Glucose/pharmacology ; Inositol/pharmacology ; Inositol Phosphates/pharmacology ; Ion Channel Gating ; Islets of Langerhans/drug effects/*metabolism ; Patch-Clamp Techniques ; Phosphoprotein Phosphatases/*antagonists & inhibitors ; Phytic Acid/*pharmacology ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 85
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    Differing roles found for estrogen's two receptors (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1439.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9304214" target="_blank"〉PubMed〈/a〉
    Keywords: Enhancer Elements, Genetic ; Estrogen Antagonists/metabolism/pharmacology ; Estrogen Receptor alpha ; Estrogen Receptor beta ; Estrogens/metabolism/pharmacology ; Gene Expression Regulation ; Genes, Reporter ; Humans ; Ligands ; Receptors, Estrogen/genetics/*physiology ; Regulatory Sequences, Nucleic Acid ; Transcription Factor AP-1/metabolism ; Tumor Cells, Cultured
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  • 86
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    Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: The immunosuppressant rapamycin interferes with G1-phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). mTOR was determined to be a terminal kinase in a signaling pathway that couples mitogenic stimulation to the phosphorylation of the eukaryotic initiation factor (eIF)-4E-binding protein, PHAS-I. The rapamycin-sensitive protein kinase activity of mTOR was required for phosphorylation of PHAS-I in insulin-stimulated human embryonic kidney cells. mTOR phosphorylated PHAS-I on serine and threonine residues in vitro, and these modifications inhibited the binding of PHAS-I to eIF-4E. These studies define a role for mTOR in translational control and offer further insights into the mechanism whereby rapamycin inhibits G1-phase progression in mammalian cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brunn, G J -- Hudson, C C -- Sekulic, A -- Williams, J M -- Hosoi, H -- Houghton, P J -- Lawrence, J C Jr -- Abraham, R T -- AR41189/AR/NIAMS NIH HHS/ -- DK28312/DK/NIDDK NIH HHS/ -- DK50628/DK/NIDDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):99-101.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204908" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Androstadienes/pharmacology ; Animals ; Carrier Proteins/pharmacology ; Cell Line ; DNA-Binding Proteins/pharmacology ; Eukaryotic Initiation Factor-4E ; G1 Phase ; Heat-Shock Proteins/pharmacology ; Humans ; Insulin/pharmacology ; Peptide Initiation Factors/metabolism ; Phosphoproteins/genetics/*metabolism ; Phosphorylation ; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors/*metabolism ; Polyenes/*pharmacology ; *Protein Kinases ; Rats ; Recombinant Proteins/metabolism ; Repressor Proteins/genetics/*metabolism ; Signal Transduction ; Sirolimus ; TOR Serine-Threonine Kinases ; Tacrolimus Binding Proteins ; Transfection ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 87
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    Laboratory workhorse decoded (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1432-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9304210" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Bacterial/genetics ; Databases, Factual ; Escherichia coli/*genetics ; *Genome, Bacterial ; Japan ; *Sequence Analysis, DNA ; Software ; United States
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  • 88
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    Government bows out of Academy case (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9340752" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Rights ; Animals ; Jurisprudence ; *National Academy of Sciences (U.S.) ; *Public Policy ; United States
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  • 89
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    Bison study marks radical shift for research council (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1786-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9206837" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Veterinary/microbiology ; Animals ; *Bison ; *Brucella abortus ; Brucellosis/epidemiology/transmission/*veterinary ; Brucellosis, Bovine/*transmission ; Cattle ; Female ; Montana/epidemiology ; *National Academy of Sciences (U.S.) ; Pregnancy ; Risk Factors ; United States
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  • 90
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    Privatized cancer journal triggers Senate reaction (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1997 Jun 6;276(5318):1492.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9190683" target="_blank"〉PubMed〈/a〉
    Keywords: *Government ; National Institutes of Health (U.S.) ; *Neoplasms ; Periodicals as Topic/*legislation & jurisprudence ; *Private Sector ; Publishing/*legislation & jurisprudence ; United States ; Universities
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  • 91
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    Selling science: at what price? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1997 Jan 17;275(5298):296-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9005547" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Financing, Government ; Government Agencies/economics ; National Institutes of Health (U.S.)/economics ; Politics ; *Research Support as Topic ; Science/*economics ; United States ; Universities/economics
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  • 92
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    A deadline for an AIDS vaccine (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- Cohen, J -- New York, N.Y. -- Science. 1997 May 23;276(5316):1184-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182323" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Ethics ; Humans ; National Institutes of Health (U.S.) ; Politics ; Research Support as Topic ; Time Factors ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Academy seeks government help to fight openness law (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 1997 Jul 25;277(5325):473.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9254418" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Welfare ; Animals ; Institute of Medicine (U.S.) ; Jurisprudence ; *National Academy of Sciences (U.S.)/organization & administration ; *Public Policy ; United States
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  • 94
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    A catalog of cancer genes at the click of a mouse (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1997 May 16;276(5315):1023-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9173535" target="_blank"〉PubMed〈/a〉
    Keywords: *Computer Communication Networks ; DNA, Complementary/genetics ; *Databases, Factual ; Europe ; Financing, Government ; Gene Expression ; *Gene Library ; Genes ; Humans ; Male ; National Institutes of Health (U.S.)/economics ; Neoplasms/*genetics ; Prostatic Neoplasms/genetics ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Raiders of the last bastion? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenwood, M R -- New York, N.Y. -- Science. 1997 Jul 11;277(5323):163.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9235625" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; Institute of Medicine (U.S.)/organization & administration ; National Academy of Sciences (U.S.)/*organization & administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 96
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    NIH leads research gains as Congress picks up pace (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- Marshall, E -- Mervis, J -- Kaiser, J -- New York, N.Y. -- Science. 1997 Jul 25;277(5325):470-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9254415" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; Government Agencies/*economics ; National Institutes of Health (U.S.)/*economics ; United States ; United States Environmental Protection Agency/economics ; United States National Aeronautics and Space Administration/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 97
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    New tumor suppressor found--twice (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1997 Mar 28;275(5308):1876-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122687" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Neoplasms/genetics ; Breast Neoplasms/genetics ; Chromosome Mapping ; *Chromosomes, Human, Pair 10 ; Female ; Gene Deletion ; *Genes, Tumor Suppressor ; Glioma/genetics ; Humans ; Male ; Microfilament Proteins/chemistry/metabolism ; Neoplasms/*genetics ; Patents as Topic ; Prostatic Neoplasms/genetics ; Protein Tyrosine Phosphatases/chemistry/*genetics/metabolism/physiology ; Publishing ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 98
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    An antidote to bioproliferation (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1222.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411746" target="_blank"〉PubMed〈/a〉
    Keywords: *Bacteria/pathogenicity ; *Biological Warfare ; *Communicable Diseases/therapy ; Government Agencies ; Humans ; *International Cooperation ; National Academy of Sciences (U.S.) ; *Research ; Russia ; United States ; *Viruses/pathogenicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 99
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    NIH, Hopkins team up on genotyping (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):153.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8999543" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Baltimore ; Financing, Government ; Genetic Diseases, Inborn/*genetics ; Genetic Markers ; *Genetics, Medical ; *Genotype ; Humans ; *National Institutes of Health (U.S.)/economics ; Research Support as Topic ; United States ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 100
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    Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-12
    Description: Protein folding in the endoplasmic reticulum (ER) often involves the formation of disulfide bonds. The oxidizing conditions required within this organelle were shown to be maintained through the release of small thiols, mainly cysteine and glutathione. Thiol secretion was stimulated when proteins rich in disulfide bonds were translocated into the ER, and secretion was prevented by the inhibition of protein synthesis. Endogenously generated cysteine and glutathione counteracted thiol-mediated retention in the ER and altered the extracellular redox. The secretion of thiols might link disulfide bond formation in the ER to intra- and intercellular redox signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carelli, S -- Ceriotti, A -- Cabibbo, A -- Fassina, G -- Ruvo, M -- Sitia, R -- New York, N.Y. -- Science. 1997 Sep 12;277(5332):1681-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉DIBIT, Istituto Scientifico San Raffaele, Milano, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9287224" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzopyrans/metabolism ; Brefeldin A ; Cycloheximide/pharmacology ; Cyclopentanes/pharmacology ; Cysteine/*secretion ; Cystine/secretion ; Disulfides/*metabolism ; Endoplasmic Reticulum/*metabolism ; Exocytosis ; Glutathione/analogs & derivatives/*secretion ; Glutathione Disulfide ; Golgi Apparatus/metabolism ; Hemagglutinin Glycoproteins, Influenza Virus/biosynthesis ; Immunoglobulin M/biosynthesis ; Immunoglobulin lambda-Chains/metabolism ; Oocytes ; Oxidation-Reduction ; Protein Synthesis Inhibitors/pharmacology ; Proteins/*metabolism ; Temperature ; Tumor Cells, Cultured ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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