Publication Date:
1997-07-04
Description:
Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4-dependent genes that lack HNF-1 binding sites in their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2, the main activation domain of HNF-4. The dual functions of gene activation and repression suggest that HNF-1 is a global regulator of the transcriptional network involved in the maintenance of hepatocyte-specific phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ktistaki, E -- Talianidis, I -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):109-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Post Office Box 1527, 711 10 Heraklion, Crete, Greece.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204893" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
;
Binding Sites
;
COS Cells
;
*DNA-Binding Proteins
;
*Gene Expression Regulation
;
Hepatocyte Nuclear Factor 1
;
Hepatocyte Nuclear Factor 1-alpha
;
Hepatocyte Nuclear Factor 1-beta
;
Hepatocyte Nuclear Factor 4
;
Humans
;
Liver/cytology/*metabolism
;
Nuclear Proteins/genetics/metabolism
;
Phosphoproteins/genetics/metabolism
;
Promoter Regions, Genetic
;
RNA, Messenger/genetics/metabolism
;
Recombinant Fusion Proteins/metabolism
;
Transcription Factors/*genetics/*metabolism
;
Transcriptional Activation
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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