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  • 1
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    Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion (2015)
    Springer Nature
    Details
    Publication Date: 2015-06-02
    Description: The pancreatic islet of Langerhans is composed of endocrine cells producing and releasing hormones from secretory granules in response to various stimuli for maintenance of blood glucose homeostasis. In order to adapt to a variation in functional demands, these islets are capable of modulating their hormone secretion by increasing the number of endocrine cells as well as the functional response of individual cells. A failure in adaptive mechanisms will lead to inadequate blood glucose regulation and thereby to the development of diabetes. It is therefore necessary to develop tools for the assessment of both pancreatic islet mass and function, with the aim of understanding cellular regulatory mechanisms and factors guiding islet plasticity. Although most of the existing techniques rely on the use of artificial indicators, we present an imaging methodology based on intrinsic optical properties originating from mature insulin secretory granules within endocrine cells that reveals both pancreatic islet mass and function. We demonstrate the advantage of using this imaging strategy by monitoring in vivo scattering signal from pancreatic islets engrafted into the anterior chamber of the mouse eye, and how this versatile and noninvasive methodology permits the characterization of islet morphology and plasticity as well as hormone secretory status. Scientific Reports 5 doi: 10.1038/srep10740
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 2
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    Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-23
    Description: Inositol hexakisphosphate (InsP6), the dominant inositol phosphate in insulin-secreting pancreatic beta cells, inhibited the serine-threonine protein phosphatases type 1, type 2A, and type 3 in a concentration-dependent manner. The activity of voltage-gated L-type calcium channels is increased in cells treated with inhibitors of serine-threonine protein phosphatases. Thus, the increased calcium channel activity obtained in the presence of InsP6 might result from the inhibition of phosphatase activity. Glucose elicited a transient increase in InsP6 concentration, which indicates that this inositol polyphosphate may modulate calcium influx over the plasma membrane and serve as a signal in the pancreatic beta cell stimulus-secretion coupling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larsson, O -- Barker, C J -- Sjoholm, A -- Carlqvist, H -- Michell, R H -- Bertorello, A -- Nilsson, T -- Honkanen, R E -- Mayr, G W -- Zwiller, J -- Berggren, P O -- New York, N.Y. -- Science. 1997 Oct 17;278(5337):471-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institute, S-171 76 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9334307" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channels/drug effects/*metabolism ; Cell Membrane/metabolism ; Cricetinae ; Dose-Response Relationship, Drug ; Glucose/pharmacology ; Inositol/pharmacology ; Inositol Phosphates/pharmacology ; Ion Channel Gating ; Islets of Langerhans/drug effects/*metabolism ; Patch-Clamp Techniques ; Phosphoprotein Phosphatases/*antagonists & inhibitors ; Phytic Acid/*pharmacology ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Cyclic ADP-ribose in beta cells (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Islam, M S -- Larsson, O -- Berggren, P O -- New York, N.Y. -- Science. 1993 Oct 22;262(5133):584-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8211188" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate Ribose/*analogs & derivatives/pharmacology/physiology ; Animals ; Calcium/*metabolism ; Cyclic ADP-Ribose ; Inositol Phosphates/pharmacology ; Islets of Langerhans/drug effects/*metabolism ; Mice ; Mice, Obese ; Microsomes/drug effects/metabolism ; Second Messenger Systems
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Cyclic ADP-ribose and pancreatic beta cells (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Islam, M S -- Larsson, O -- Berggren, P O -- New York, N.Y. -- Science. 1993 Dec 3;262(5139):1499.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8248793" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate Ribose/*analogs & derivatives/pharmacology ; Animals ; Cyclic ADP-Ribose ; Glucose/*pharmacology ; Islets of Langerhans/*drug effects ; Mice ; Mice, Obese
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-02-09
    Description: Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eliasson, L -- Renstrom, E -- Ammala, C -- Berggren, P O -- Bertorello, A M -- Bokvist, K -- Chibalin, A -- Deeney, J T -- Flatt, P R -- Gabel, J -- Gromada, J -- Larsson, O -- Lindstrom, P -- Rhodes, C J -- Rorsman, P -- New York, N.Y. -- Science. 1996 Feb 9;271(5250):813-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Pharmacology, University of Goteborg, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8628999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Cells, Cultured ; Cytoplasmic Granules/metabolism ; Electric Conductivity ; Exocytosis/*drug effects ; Glipizide/pharmacology ; Glyburide/pharmacology ; Hypoglycemic Agents/*pharmacology ; Insulin/secretion ; Islets of Langerhans/drug effects/*physiology ; Membrane Potentials/drug effects ; Mice ; Patch-Clamp Techniques ; Protein Kinase C/*metabolism ; Sulfonylurea Compounds/*pharmacology ; Tolbutamide/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-11-24
    Description: Inositol pyrophosphates are recognized components of cellular processes that regulate vesicle trafficking, telomere length, and apoptosis. We observed that pancreatic beta cells maintain high basal concentrations of the pyrophosphate diphosphoinositol pentakisphosphate (InsP7 or IP7). Inositol hexakisphosphate kinases (IP6Ks) that can generate IP7 were overexpressed. This overexpression stimulated exocytosis of insulin-containing granules from the readily releasable pool. Exogenously applied IP7 dose-dependently enhanced exocytosis at physiological concentrations. We determined that IP6K1 and IP6K2 were present in beta cells. RNA silencing of IP6K1, but not IP6K2, inhibited exocytosis, which suggests that IP6K1 is the critical endogenous kinase. Maintenance of high concentrations of IP7 in the pancreatic beta cell may enhance the immediate exocytotic capacity and consequently allow rapid adjustment of insulin secretion in response to increased demand.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Illies, Christopher -- Gromada, Jesper -- Fiume, Roberta -- Leibiger, Barbara -- Yu, Jia -- Juhl, Kirstine -- Yang, Shao-Nian -- Barma, Deb K -- Falck, John R -- Saiardi, Adolfo -- Barker, Christopher J -- Berggren, Per-Olof -- GM31278/GM/NIGMS NIH HHS/ -- MC_U122680443/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2007 Nov 23;318(5854):1299-302.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18033884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cricetinae ; Electric Capacitance ; *Exocytosis ; Inositol Phosphates/*metabolism ; Insulin/*secretion ; Insulin-Secreting Cells/*metabolism/secretion ; Islets of Langerhans/metabolism ; Mice ; Patch-Clamp Techniques ; Phosphotransferases (Phosphate Group Acceptor)/genetics/metabolism ; Phytic Acid/metabolism ; RNA Interference ; Rats ; Secretory Vesicles/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Extracellular Ca^2^+ induces a rapid increase in cytoplasmic free Ca^2^+ in pancreatic β-cells
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 149 (1987), S. 152-158 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(87)91617-2
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The determination of barium, lanthanum and magnesium in pancreatic islets by electrothermal atomic absorption spectrometry
    Amsterdam : Elsevier
    Analytica Chimica Acta 119 (1980), S. 161-166 
    Details
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(00)00043-X
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  • 9
    Electronic Resource
    Electronic Resource
    Determination of calcium in microgram amounts of dried biological material by flameless atomic absorption spectrophotometry with special reference to the pancreatic islets
    Amsterdam : Elsevier
    Analytical Biochemistry 84 (1978), S. 393-401 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(78)90056-8
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  • 10
    Electronic Resource
    Electronic Resource
    Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca^2^+ sequestration in permeabilised insulin-secreting cells
    Amsterdam : Elsevier
    FEBS Letters 288 (1991), S. 27-29 
    Details
    ISSN: 0014-5793
    Keywords: Inositol 1,4,5-trisphospate ; Inositol 1,4,5-trisphosphate receptor ; Insulin-secreting cell ; Intracellular Ca^2^+-transport
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80995-F
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