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  • Articles  (361)
  • United States  (276)
  • Tumor Cells, Cultured  (85)
  • American Association for the Advancement of Science (AAAS)  (361)
  • 1995-1999  (361)
  • 1999  (199)
  • 1997  (162)
Collection
  • Articles  (361)
Source
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (361)
  • Springer  (6)
Years
  • 1995-1999  (361)
Year
Journal
Topic
  • 101
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    Religion and science (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, S -- New York, N.Y. -- Science. 1999 Jun 11;284(5421):1773.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10391793" target="_blank"〉PubMed〈/a〉
    Keywords: Foundations ; *Religion and Science ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 102
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    NCI asked to increase focus on minorities (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agnew, B -- New York, N.Y. -- Science. 1999 Jan 29;283(5402):615-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9988652" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Humans ; Institute of Medicine (U.S.) ; Medically Underserved Area ; *Minority Groups ; *National Institutes of Health (U.S.) ; Neoplasms/*ethnology ; Research Support as Topic ; Risk Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-26
    Description: Dysregulation of Wnt-beta-catenin signaling disrupts axis formation in vertebrate embryos and underlies multiple human malignancies. The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta form a Wnt-regulated signaling complex that mediates the phosphorylation-dependent degradation of beta-catenin. A protein phosphatase 2A (PP2A) regulatory subunit, B56, interacted with APC in the yeast two-hybrid system. Expression of B56 reduced the abundance of beta-catenin and inhibited transcription of beta-catenin target genes in mammalian cells and Xenopus embryo explants. The B56-dependent decrease in beta-catenin was blocked by oncogenic mutations in beta-catenin or APC, and by proteasome inhibitors. B56 may direct PP2A to dephosphorylate specific components of the APC-dependent signaling complex and thereby inhibit Wnt signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seeling, J M -- Miller, J R -- Gil, R -- Moon, R T -- White, R -- Virshup, D M -- 3P30CA42014/CA/NCI NIH HHS/ -- R01 CA71074/CA/NCI NIH HHS/ -- T32CA09602/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Mar 26;283(5410):2089-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10092233" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli Protein ; Animals ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cell Line ; Cysteine Endopeptidases/metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Cytoskeletal Proteins/genetics/*metabolism ; Down-Regulation ; Genes, Reporter ; Glycogen Synthase Kinase 3 ; Glycogen Synthase Kinases ; Humans ; Leupeptins/pharmacology ; Multienzyme Complexes/metabolism ; Mutation ; Phosphoprotein Phosphatases/chemistry/genetics/*metabolism ; Phosphorylation ; Proteasome Endopeptidase Complex ; Protein Phosphatase 2 ; Proto-Oncogene Proteins/*metabolism ; *Signal Transduction ; *Trans-Activators ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured ; Wnt Proteins ; Xenopus ; Xenopus Proteins ; *Zebrafish Proteins ; beta Catenin
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
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    Scientific leaders balk at broad data release (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agnew, B -- New York, N.Y. -- Science. 1999 Jan 15;283(5400):307, 309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9925482" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; Financing, Government ; Intellectual Property ; *Public Policy ; Research/*legislation & jurisprudence ; *Research Support as Topic ; Truth Disclosure ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
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    Xenografts and retroviruses (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, R A -- New York, N.Y. -- Science. 1999 Aug 20;285(5431):1221-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wohl Virion Centre, Windeyer Institute of Medical Sciences, Univesity College, London W1) 6DB, UK. r.weiss@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10484730" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; *Gammaretrovirus/genetics/isolation & purification/physiology ; Graft Rejection ; Humans ; Retroviridae Infections/diagnosis/*transmission/virology ; *Risk Assessment ; Swine ; *Transplantation, Heterologous/adverse effects ; Tumor Virus Infections/diagnosis/*transmission/virology ; United States ; United States Food and Drug Administration ; Viremia/diagnosis ; Virus Replication ; *Zoonoses
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 106
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    Research shutdown roils Los Angeles VA (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Apr 2;284(5411):18-9, 21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10215523" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation ; *Clinical Trials as Topic ; Ethics Committees, Research ; *Federal Government ; Financing, Government ; *Government Regulation ; *Hospitals, Veterans ; Humans ; Informed Consent ; Los Angeles ; *Research ; Research Support as Topic ; United States ; *United States Department of Veterans Affairs/organization & administration ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
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    Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, B M -- Ayala, F J -- Botstein, D -- Frank, E -- Holmes, E W -- Lee, R D -- Macagno, E R -- Marrack, P -- Oparil, S -- Orkin, S H -- Rubenstein, A H -- Slayman, C W -- Sparling, P F -- Squire, L R -- von Hippel, P H -- Yamamoto, K R -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):666-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10454921" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/*organization & administration ; *Peer Review, Research ; Public Policy ; Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 108
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    Colorado Nobelist chosen to lead Howard Hughes (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Apr 2;284(5411):18.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10215522" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/*organization & administration ; Administrative Personnel ; Colorado ; History, 20th Century ; Nobel Prize ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    Nabel to head NIH Vaccine Research Center (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Mar 19;283(5409):1829, 1831.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206884" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Administrative Personnel ; History, 20th Century ; National Institutes of Health (U.S.)/*organization & administration ; Research ; United States ; Vaccines
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    Scientific publications. The march of paradigms (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Mar 26;283(5410):1998-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206899" target="_blank"〉PubMed〈/a〉
    Keywords: Medline ; *Publishing ; *Terminology as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 111
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    Genetic mechanisms of age regulation of human blood coagulation factor IX (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-31
    Description: Blood coagulation capacity increases with age in healthy individuals. Through extensive longitudinal analyses of human factor IX gene expression in transgenic mice, two essential age-regulatory elements, AE5' and AE3', have been identified. These elements are required and together are sufficient for normal age regulation of factor IX expression. AE5', a PEA-3 related element present in the 5' upstream region of the gene encoding factor IX, is responsible for age-stable expression of the gene. AE3', in the middle of the 3' untranslated region, is responsible for age-associated elevation in messenger RNA levels. In a concerted manner, AE5' and AE3' recapitulate natural patterns of the advancing age-associated increase in factor IX gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurachi, S -- Deyashiki, Y -- Takeshita, J -- Kurachi, K -- AG13283/AG/NIA NIH HHS/ -- HL38644/HL/NHLBI NIH HHS/ -- HL53713/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):739-43.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109-0618, USA. kkurachi@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10426997" target="_blank"〉PubMed〈/a〉
    Keywords: *3' Untranslated Regions ; Aging/blood/*genetics ; Animals ; Consensus Sequence ; DNA Footprinting ; Dinucleotide Repeats ; Factor IX/*genetics/metabolism ; Female ; *Gene Expression Regulation ; Genetic Vectors ; Humans ; Male ; Mice ; Mice, Transgenic ; RNA, Messenger/genetics/metabolism ; *Regulatory Sequences, Nucleic Acid ; Transcription Factors/genetics/metabolism ; Transcription, Genetic ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
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    Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-31
    Description: Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-kappaB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aliprantis, A O -- Yang, R B -- Mark, M R -- Suggett, S -- Devaux, B -- Radolf, J D -- Klimpel, G R -- Godowski, P -- Zychlinsky, A -- AI 37720-04/AI/NIAID NIH HHS/ -- AI-38894/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):736-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10426996" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal ; Antigens, CD14/analysis ; *Apoptosis ; Bacterial Proteins/metabolism/*pharmacology ; Cell Line/metabolism ; Cycloheximide/pharmacology ; Cytotoxicity, Immunologic ; *Drosophila Proteins ; Genes, Reporter ; Humans ; Lipopolysaccharides/immunology ; Lipoproteins/metabolism/*pharmacology ; Membrane Glycoproteins/immunology/*metabolism ; Monocytes/*cytology/immunology/metabolism ; NF-kappa B/metabolism ; Protein Synthesis Inhibitors/pharmacology ; Reactive Oxygen Species/metabolism ; Receptors, Cell Surface/immunology/*metabolism ; Signal Transduction ; Tetradecanoylphorbol Acetate/pharmacology ; Toll-Like Receptor 2 ; Toll-Like Receptors ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
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    Fusion-competent vaccines: broad neutralization of primary isolates of HIV (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-15
    Description: Current recombinant human immunodeficiency virus (HIV) gp120 protein vaccine candidates are unable to elicit antibodies capable of neutralizing infectivity of primary isolates from patients. Here, "fusion-competent" HIV vaccine immunogens were generated that capture the transient envelope-CD4-coreceptor structures that arise during HIV binding and fusion. In a transgenic mouse immunization model, these formaldehyde-fixed whole-cell vaccines elicited antibodies capable of neutralizing infectivity of 23 of 24 primary HIV isolates from diverse geographic locations and genetic clades A to E. Development of these fusion-dependent immunogens may lead to a broadly effective HIV vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉LaCasse, R A -- Follis, K E -- Trahey, M -- Scarborough, J D -- Littman, D R -- Nunberg, J H -- AI33856/AI/NIAID NIH HHS/ -- AI41165/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 15;283(5400):357-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Montana Biotechnology Center and Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9888845" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*immunology ; Animals ; Antigens, CD4/metabolism ; Cell Fusion ; Coculture Techniques ; Epitopes/immunology ; Gene Products, env/chemistry/*immunology/metabolism ; Giant Cells ; HIV Antibodies/biosynthesis/*immunology ; HIV Antigens/chemistry/*immunology ; HIV Envelope Protein gp120/chemistry/immunology/metabolism ; HIV Envelope Protein gp41/chemistry/immunology/metabolism ; HIV Infections/virology ; HIV-1/*immunology/isolation & purification/physiology ; Humans ; Mice ; Mice, Transgenic ; Neutralization Tests ; Protein Conformation ; Receptors, CCR5/metabolism ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 114
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    Stem cells profile. A man in a hurry (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alper, J -- New York, N.Y. -- Science. 1999 Mar 5;283(5407):1434-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206867" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Bioethics ; *Biomedical Research ; Cattle ; Embryo Research ; Embryo, Mammalian/*cytology ; *Genetic Research ; History, 20th Century ; Humans ; Hybrid Cells ; Nuclear Transfer Techniques ; *Research ; *Stem Cells ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 115
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    A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-30
    Description: Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Banfi, B -- Maturana, A -- Jaconi, S -- Arnaudeau, S -- Laforge, T -- Sinha, B -- Ligeti, E -- Demaurex, N -- Krause, K H -- New York, N.Y. -- Science. 2000 Jan 7;287(5450):138-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, Geneva Medical School, CH-1211 Geneva 4, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10615049" target="_blank"〉PubMed〈/a〉
    Keywords: *Alternative Splicing ; Amino Acid Sequence ; Cell Line ; Cytosol/metabolism ; Electric Conductivity ; Electron Transport ; Expressed Sequence Tags ; Humans ; Hydrogen/*metabolism ; Hydrogen-Ion Concentration ; Ion Channel Gating ; Ion Channels/chemistry/*genetics/metabolism ; Membrane Glycoproteins/chemistry/*genetics ; Molecular Sequence Data ; NADPH Oxidase/chemistry/*genetics ; Patch-Clamp Techniques ; Protons ; Transfection ; Tumor Cells, Cultured ; Zinc/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 116
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    An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-27
    Description: Candida glabrata is an important fungal pathogen of humans that is responsible for about 15 percent of mucosal and systemic candidiasis. Candida glabrata adhered avidly to human epithelial cells in culture. By means of a genetic approach and a strategy allowing parallel screening of mutants, it was possible to clone a lectin from a Candida species. Deletion of this adhesin reduced adherence of C. glabrata to human epithelial cells by 95 percent. The adhesin, encoded by the EPA1 gene, is likely a glucan-cross-linked cell-wall protein and binds to host-cell carbohydrate, specifically recognizing asialo-lactosyl-containing carbohydrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cormack, B P -- Ghori, N -- Falkow, S -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):578-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild D039, 299 Campus Drive, Stanford, CA 94305-5124, USA. bcormack@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10417386" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Calcium/metabolism ; Candida/*genetics/*pathogenicity/physiology ; Candidiasis, Vulvovaginal/microbiology ; Carbohydrates/pharmacology ; Cell Adhesion ; Cloning, Molecular ; Epithelial Cells/*microbiology ; Female ; *Fungal Proteins ; Genes, Fungal ; Humans ; Lectins/chemistry/*genetics/metabolism ; Ligands ; Mice ; Mice, Inbred DBA ; Molecular Sequence Data ; Mutagenesis, Insertional ; Mutation ; Plasmids ; Polymerase Chain Reaction ; Transformation, Genetic ; Tumor Cells, Cultured ; Virulence/genetics
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  • 117
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    Reducing natural disasters (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, N -- New York, N.Y. -- Science. 1999 Sep 17;285(5435):1850-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10515788" target="_blank"〉PubMed〈/a〉
    Keywords: Disaster Planning/*organization & administration ; *Disasters ; Private Sector ; Public Policy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Inner sanctum (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook-Deegan, R M -- New York, N.Y. -- Science. 1999 Apr 23;284(5414):589.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10328738" target="_blank"〉PubMed〈/a〉
    Keywords: *Consumer Participation ; *National Institutes of Health (U.S.) ; *Patient Advocacy ; *Peer Review, Research ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-31
    Description: Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bauer, S -- Groh, V -- Wu, J -- Steinle, A -- Phillips, J H -- Lanier, L L -- Spies, T -- P01 CA18221/CA/NCI NIH HHS/ -- R01 AI30581/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):727-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10426993" target="_blank"〉PubMed〈/a〉
    Keywords: Cytotoxicity, Immunologic ; Histocompatibility Antigens Class I/*immunology/metabolism ; Humans ; Jurkat Cells ; Killer Cells, Natural/*immunology ; Ligands ; *Lymphocyte Activation ; Lymphocyte Subsets/immunology ; Membrane Proteins/metabolism ; NK Cell Lectin-Like Receptor Subfamily K ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Receptors, Immunologic/chemistry/genetics/*immunology/metabolism ; Receptors, Natural Killer Cell ; Signal Transduction ; T-Lymphocytes/*immunology ; Transfection ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Perspectives: evolutionary biology. The evolutionary synthesis (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stenseth, N C -- New York, N.Y. -- Science. 1999 Nov 19;286(5444):1490.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Oslo, Oslo, Norway. n.c.stenseth@bio.uio.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610549" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; *Awards and Prizes ; *Biological Evolution ; England ; History, 20th Century ; Selection, Genetic ; Sweden ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S., European backers differ on E-biomed plan (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):315.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10438291" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; *Internet ; National Institutes of Health (U.S.) ; Peer Review, Research ; *Publishing ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    DOE builds a web site for the physical sciences (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Aug 6;285(5429):811.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10454925" target="_blank"〉PubMed〈/a〉
    Keywords: *Government Agencies ; *Information Systems ; *Internet ; *Natural Science Disciplines ; *Publishing ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Martin Rodbell (1925-1998) (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnbaumer, L -- New York, N.Y. -- Science. 1999 Mar 12;283(5408):1656.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA. lutzb@ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10189319" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; Models, Biological ; Physiology/history ; *Signal Transduction ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-26
    Description: Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling to regulate cell growth and differentiation. The SnoN oncoprotein was found to interact with Smad2 and Smad4 and to repress their abilities to activate transcription through recruitment of the transcriptional corepressor N-CoR. Immediately after TGF-beta stimulation, SnoN is rapidly degraded by the nuclear accumulation of Smad3, allowing the activation of TGF-beta target genes. By 2 hours, TGF-beta induces a marked increase in SnoN expression, resulting in termination of Smad-mediated transactivation. Thus, SnoN maintains the repressed state of TGF-beta-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stroschein, S L -- Wang, W -- Zhou, S -- Zhou, Q -- Luo, K -- New York, N.Y. -- Science. 1999 Oct 22;286(5440):771-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10531062" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cell Line ; Cell Nucleus/metabolism ; DNA/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Feedback ; *Gene Expression Regulation ; Humans ; Intracellular Signaling Peptides and Proteins ; Nuclear Proteins/metabolism ; Nuclear Receptor Co-Repressor 1 ; Promoter Regions, Genetic ; Proto-Oncogene Proteins/genetics/*metabolism ; Repressor Proteins/metabolism ; *Signal Transduction ; Smad2 Protein ; Smad3 Protein ; Smad4 Protein ; Trans-Activators/genetics/metabolism ; Transcription Factors/genetics/*metabolism ; Transcriptional Activation ; Transfection ; Transforming Growth Factor beta/*metabolism ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Mitigating natural disasters (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Press, F -- Hamilton, R M -- New York, N.Y. -- Science. 1999 Jun 18;284(5422):1927.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10400533" target="_blank"〉PubMed〈/a〉
    Keywords: *Disaster Planning/organization & administration/trends ; *Disasters ; Public Policy ; United Nations ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Redefining rats, mice, and birds. AAA (American Association of Anatomists) Public Affairs Committee (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Besharse, J C -- Carlson, B M -- Jenkins, D P -- Lester, D S -- Olds, J L -- Satir, P -- New York, N.Y. -- Science. 1999 Apr 2;284(5411):49-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10215528" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Rights/*legislation & jurisprudence ; Animal Welfare/*legislation & jurisprudence ; Animals ; *Animals, Laboratory ; Birds ; Mice ; Rats ; Research ; Societies, Scientific ; United States ; United States Department of Agriculture/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    President revokes plan to destroy smallpox (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Apr 30;284(5415):718-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10336389" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; Containment of Biohazards ; Institute of Medicine (U.S.) ; Preservation, Biological ; Smallpox Vaccine ; United States ; *Variola virus ; Violence ; World Health Organization
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The Frist-Rockefeller scenario (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lubell, M S -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):338-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10438296" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; National Institutes of Health (U.S.)/*economics/legislation & jurisprudence ; Politics ; Research/economics/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    NIH ethics office tapped for a promotion (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Jun 11;284(5421):1749, 1751.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10391786" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bioethics ; Budgets ; Human Experimentation ; Humans ; National Institutes of Health (U.S.)/*organization & administration ; Public Policy ; Research/*standards ; United States ; United States Dept. of Health and Human Services/*organization & administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Which Jefferson was the father? (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Jan 8;283(5399):153-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9925468" target="_blank"〉PubMed〈/a〉
    Keywords: Dna ; *Famous Persons ; Female ; History, 18th Century ; History, 19th Century ; Humans ; Male ; *Paternity ; Politics ; Publishing ; United States ; Y Chromosome
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  • 131
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    New type of blood vessel found in tumors (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1999 Sep 3;285(5433):1475.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10498529" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/therapeutic use ; Endothelium, Vascular/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Melanoma/*blood supply/drug therapy/genetics/pathology ; *Neovascularization, Pathologic/drug therapy ; Tumor Cells, Cultured ; Uveal Neoplasms/*blood supply/drug therapy/genetics/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Kennewick man gets his day in the lab (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1239-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10084923" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; History, Ancient ; Humans ; *Indians, North American ; Male ; *Paleontology ; Skeleton ; Skull ; United States ; Washington
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    Budget finale. NIH gets $17.9 billion in another record year (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 1999 Nov 26;286(5445):1654.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610554" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics/organization & administration ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Novel endotheliotropic herpesviruses fatal for Asian and African elephants (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-19
    Description: A highly fatal hemorrhagic disease has been identified in 10 young Asian and African elephants at North American zoos. In the affected animals there was ultrastructural evidence for herpesvirus-like particles in endothelial cells of the heart, liver, and tongue. Consensus primer polymerase chain reaction combined with sequencing yielded molecular evidence that confirmed the presence of two novel but related herpesviruses associated with the disease, one in Asian elephants and another in African elephants. Otherwise healthy African elephants with external herpetic lesions yielded herpesvirus sequences identical to that found in Asian elephants with endothelial disease. This finding suggests that the Asian elephant deaths were caused by cross-species infection with a herpesvirus that is naturally latent in, but normally not lethal to, African elephants. A reciprocal relationship may exist for the African elephant disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richman, L K -- Montali, R J -- Garber, R L -- Kennedy, M A -- Lehnhardt, J -- Hildebrandt, T -- Schmitt, D -- Hardy, D -- Alcendor, D J -- Hayward, G S -- 1 K08 AI01526-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1999 Feb 19;283(5405):1171-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Smithsonian, National Zoological Park, Washington, DC 20008, USA. lkrichma@welchlink.welch.jhu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10024244" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Amino Acid Sequence ; Animals ; Animals, Zoo/*virology ; Asia ; Base Sequence ; DNA, Viral/genetics ; DNA-Directed DNA Polymerase/chemistry/genetics ; Elephants/*virology ; Endodeoxyribonucleases/chemistry/genetics ; Endothelium, Vascular/pathology/*virology ; Female ; Genes, Viral ; Hemorrhage/pathology/veterinary/virology ; Herpesviridae/classification/genetics/*isolation & purification ; Herpesviridae Infections/pathology/transmission/*veterinary/virology ; Inclusion Bodies, Viral/ultrastructure ; Male ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction ; United States ; Viral Proteins/genetics
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    Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-31
    Description: The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brightbill, H D -- Libraty, D H -- Krutzik, S R -- Yang, R B -- Belisle, J T -- Bleharski, J R -- Maitland, M -- Norgard, M V -- Plevy, S E -- Smale, S T -- Brennan, P J -- Bloom, B R -- Godowski, P J -- Modlin, R L -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):732-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, Los Anges, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10426995" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Bacterial/chemistry/*immunology/metabolism ; Cell Line ; *Drosophila Proteins ; Gene Expression Regulation ; Humans ; Interleukin-12/*biosynthesis/genetics ; Lipopolysaccharides/immunology ; Lipoproteins/chemistry/*immunology/metabolism ; Macrophages/*immunology/metabolism ; Membrane Glycoproteins/*metabolism ; Mice ; Monocytes/*immunology/metabolism ; Mycobacterium tuberculosis/*immunology ; NF-kappa B/biosynthesis ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase Type II ; Promoter Regions, Genetic ; Receptors, Cell Surface/*metabolism ; Signal Transduction ; Toll-Like Receptors ; Transcription, Genetic ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Community divides over push for bigger budget (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 1999 May 28;284(5419):1452-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10383319" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets/legislation & jurisprudence ; National Institutes of Health (U.S.)/*economics/legislation & jurisprudence ; *Politics ; Research/*economics/legislation & jurisprudence ; Research Support as Topic/legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Are genetic tests adequately regulated? (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holtzman, N A -- New York, N.Y. -- Science. 1999 Oct 15;286(5439):409.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577197" target="_blank"〉PubMed〈/a〉
    Keywords: Genetic Testing/legislation & jurisprudence/*standards ; *Government Regulation ; Humans ; Predictive Value of Tests ; Probability ; Risk Factors ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 138
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    Phosphorylation and regulation of Raf by Akt (protein kinase B) (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-27
    Description: Activation of the protein kinase Raf can lead to opposing cellular responses such as proliferation, growth arrest, apoptosis, or differentiation. Akt (protein kinase B), a member of a different signaling pathway that also regulates these responses, interacted with Raf and phosphorylated this protein at a highly conserved serine residue in its regulatory domain in vivo. This phosphorylation of Raf by Akt inhibited activation of the Raf-MEK-ERK signaling pathway and shifted the cellular response in a human breast cancer cell line from cell cycle arrest to proliferation. These observations provide a molecular basis for cross talk between two signaling pathways at the level of Raf and Akt.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zimmermann, S -- Moelling, K -- New York, N.Y. -- Science. 1999 Nov 26;286(5445):1741-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medical Virology, University of Zurich, Gloriastrasse 30/32, CH-8028 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10576742" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Division ; Cell Line ; Chromones/pharmacology ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins/metabolism ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Epidermal Growth Factor/pharmacology ; Flavonoids/pharmacology ; Humans ; *MAP Kinase Signaling System ; Morpholines/pharmacology ; Phosphatidylinositol 3-Kinases/antagonists & inhibitors/metabolism ; Phosphorylation ; Phosphoserine/metabolism ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/*metabolism ; Proto-Oncogene Proteins/antagonists & inhibitors/*metabolism ; Proto-Oncogene Proteins c-akt ; Proto-Oncogene Proteins c-raf/antagonists & inhibitors/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Somatomedins/pharmacology ; Tetradecanoylphorbol Acetate/pharmacology ; Tumor Cells, Cultured ; ras Proteins/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 139
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    Disappearing physician-scientists (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Varki, A -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):791-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10049120" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; Humans ; *Physicians/statistics & numerical data/trends ; *Research ; *Research Personnel/statistics & numerical data/trends ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 140
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    Scientific misconduct. Baylor saga comes to an end (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1999 Feb 19;283(5405):1091.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10075561" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; Federal Government ; *Government Regulation ; Jurisprudence ; Scientific Misconduct/*legislation & jurisprudence ; Texas ; United States ; United States Office of Research Integrity ; Universities/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 141
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    RAC nixes plan to treat retinoblastoma (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garber, K -- New York, N.Y. -- Science. 1999 Jun 25;284(5423):2066.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10409057" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Child, Preschool ; Clinical Protocols ; Clinical Trials as Topic ; DNA, Recombinant ; Federal Government ; *Genetic Therapy/adverse effects ; *Government Regulation ; Humans ; Infant ; National Institutes of Health (U.S.) ; *Public Policy ; Retinal Neoplasms/*therapy ; Retinoblastoma/*therapy ; *Risk Assessment ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 142
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    Worlds apart? The reception of genetically modified foods in Europe and the U.S (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-20
    Description: Recent controversies about genetically modified foods in the United Kingdom and several other European countries highlight the apparent differences that exist in public opinion on this subject across the Atlantic. Why are people in the United States seemingly untroubled by a technology that causes Europeans so many difficulties? The results of survey research on public perceptions of biotechnology in Europe and the United States during 1996-1997, together with an analysis of press coverage and policy formation from 1984 to 1996, can help to answer this question.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaskell, G -- Bauer, M W -- Durant, J -- Allum, N C -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):384-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Methodology Institute, Department of Social Psychology, London School of Economics, London WC2A 2AE, UK. G.Gaskell@lse.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10411496" target="_blank"〉PubMed〈/a〉
    Keywords: *Attitude ; *Biotechnology ; Crops, Agricultural/genetics ; Data Collection ; Europe ; *Food ; *Genetic Engineering ; Government Agencies ; Government Regulation ; Health Knowledge, Attitudes, Practice ; *Internationality ; Newspapers as Topic ; *Public Opinion ; Public Policy ; *Risk Assessment ; Transplantation, Heterologous ; Trust ; United Nations ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 143
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    Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-18
    Description: Mutations in APC or beta-catenin inappropriately activate the transcription factor Tcf4, thereby transforming intestinal epithelial cells. Here it is shown that one of the target genes of Tcf4 in epithelial cells is Tcf1. The most abundant Tcf1 isoforms lack a beta-catenin interaction domain. Tcf1(-/-) mice develop adenomas in the gut and mammary glands. Introduction of a mutant APC allele into these mice substantially increases the number of these adenomas. Tcf1 may act as a feedback repressor of beta-catenin-Tcf4 target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roose, J -- Huls, G -- van Beest, M -- Moerer, P -- van der Horn, K -- Goldschmeding, R -- Logtenberg, T -- Clevers, H -- New York, N.Y. -- Science. 1999 Sep 17;285(5435):1923-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Center for Biomedical Genetics, Department of Pathology, University Medical Center Utrecht, Post Office Box 85500, 3508 GA Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10489374" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/genetics/metabolism/pathology ; Adenomatous Polyposis Coli Protein ; Animals ; Cytoskeletal Proteins/*metabolism ; DNA-Binding Proteins/*genetics/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Hepatocyte Nuclear Factor 1-alpha ; Humans ; Intestinal Neoplasms/genetics/metabolism/pathology ; Lymphoid Enhancer-Binding Factor 1 ; Male ; Mammary Neoplasms, Experimental/genetics/metabolism/pathology ; Mice ; Neoplasm Proteins/metabolism ; Promoter Regions, Genetic ; T Cell Transcription Factor 1 ; TCF Transcription Factors ; *Trans-Activators ; Transcription Factor 7-Like 2 Protein ; Transcription Factors/*genetics/*metabolism ; Transfection ; Tumor Cells, Cultured ; beta Catenin
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 144
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    Physician-scientists at risk (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cameron, O G -- New York, N.Y. -- Science. 1999 Mar 5;283(5407):1456.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206873" target="_blank"〉PubMed〈/a〉
    Keywords: Managed Care Programs ; *Research ; *Research Support as Topic ; Schools, Medical/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 145
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    Keck helps five careers with $1 million grants (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, J -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):312-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10438290" target="_blank"〉PubMed〈/a〉
    Keywords: Academic Medical Centers ; *Faculty ; *Foundations ; *Research Support as Topic ; United States ; Universities
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  • 146
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    p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-26
    Description: Although broken chromosomes can induce apoptosis, natural chromosome ends (telomeres) do not trigger this response. It is shown that this suppression of apoptosis involves the telomeric-repeat binding factor 2 (TRF2). Inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. The response was mediated by p53 and the ATM (ataxia telangiectasia mutated) kinase, consistent with activation of a DNA damage checkpoint. Apoptosis was not due to rupture of dicentric chromosomes formed by end-to-end fusion, indicating that telomeres lacking TRF2 directly signal apoptosis, possibly because they resemble damaged DNA. Thus, in some cells, telomere shortening may signal cell death rather than senescence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karlseder, J -- Broccoli, D -- Dai, Y -- Hardy, S -- de Lange, T -- GM49046/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1321-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA. Cell Genesys, Foster City, CA 94405, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10037601" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviridae/genetics/physiology ; Animals ; *Apoptosis ; Ataxia Telangiectasia/pathology ; Ataxia Telangiectasia Mutated Proteins ; B-Lymphocytes/cytology ; Cell Cycle Proteins ; Cell Line ; Cells, Cultured ; Cloning, Molecular ; DNA Damage ; DNA-Binding Proteins/chemistry/genetics/*physiology ; Genetic Vectors ; Humans ; In Situ Nick-End Labeling ; Mice ; Mitosis ; Phosphorylation ; *Protein-Serine-Threonine Kinases ; Proteins/metabolism ; T-Lymphocytes/cytology ; Telomere/*physiology ; Telomeric Repeat Binding Protein 2 ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/*metabolism ; Tumor Suppressor Proteins
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  • 147
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    The conditional mutator phenotype in human tumor cells: correction (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuth, M -- Richards, B -- Schneider, B -- New York, N.Y. -- Science. 1999 Jan 29;283(5402):641.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9988656" target="_blank"〉PubMed〈/a〉
    Keywords: *Blood ; Cell Culture Techniques ; *Cell Division ; Culture Media ; Humans ; *Mutation ; Neoplasms/*genetics/pathology ; Phenotype ; Tumor Cells, Cultured
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  • 148
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    E-publication proposal (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirschner, M W -- New York, N.Y. -- Science. 1999 Aug 13;285(5430):1013.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10475839" target="_blank"〉PubMed〈/a〉
    Keywords: *Internet ; National Institutes of Health (U.S.) ; Periodicals as Topic ; *Publishing ; United States
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  • 149
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    FDA weighs using tumor cell lines for vaccine development (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1999 Sep 17;285(5435):1826-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10515783" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Neoplasms/etiology ; Risk Assessment ; *Tumor Cells, Cultured ; United States ; *United States Food and Drug Administration ; Vaccines/adverse effects/*biosynthesis ; Viral Vaccines/biosynthesis
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  • 150
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    Genetic enhancement in humans (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordon, J W -- New York, N.Y. -- Science. 1999 Mar 26;283(5410):2023-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Laboratory Animal Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA. jgordon@smtplink.mssm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206908" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation ; Animals ; Bioethics ; Biological Evolution ; Breeding ; Embryo Research ; *Eugenics/legislation & jurisprudence ; *Gene Transfer Techniques ; *Genetic Engineering/legislation & jurisprudence ; *Genetic Enhancement ; Genetic Research ; Humans ; Informed Consent ; Public Policy ; Reproductive Techniques ; Research/legislation & jurisprudence ; Risk Assessment ; Selection, Genetic ; Social Responsibility ; Transgenes ; United States
    Print ISSN: 0036-8075
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  • 151
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    Mouse tumor model for neurofibromatosis type 1 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-11
    Description: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by increased incidence of benign and malignant tumors of neural crest origin. Mutations that activate the protooncogene ras, such as loss of Nf1, cooperate with inactivating mutations at the p53 tumor suppressor gene during malignant transformation. One hundred percent of mice harboring null Nf1 and p53 alleles in cis synergize to develop soft tissue sarcomas between 3 and 7 months of age. These sarcomas exhibit loss of heterozygosity at both gene loci and express phenotypic traits characteristic of neural crest derivatives and human NF1 malignancies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079436/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079436/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, K S -- Klesse, L J -- Velasco-Miguel, S -- Meyers, K -- Rushing, E J -- Parada, L F -- NS34296/NS/NINDS NIH HHS/ -- R01 NS034296/NS/NINDS NIH HHS/ -- R01 NS034296-04/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1999 Dec 10;286(5447):2176-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Developmental Biology and Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75235-9133, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10591653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomarkers, Tumor ; Cell Differentiation ; Cell Transformation, Neoplastic ; Crosses, Genetic ; *Disease Models, Animal ; Female ; *Genes, Neurofibromatosis 1 ; *Genes, p53 ; Heterozygote ; Humans ; Loss of Heterozygosity ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Neural Crest/metabolism/pathology ; Neurofibromatosis 1/*genetics/*pathology ; Sarcoma/genetics/*pathology ; Schwann Cells/metabolism/pathology ; Tumor Cells, Cultured
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  • 152
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    Looking for a few good mutants (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, W E -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):539, 541.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA. goldman@borcim.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10447486" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Candida/*genetics/*pathogenicity/physiology ; Cell Adhesion ; DNA Transposable Elements ; Epithelial Cells/*microbiology ; *Fungal Proteins ; Genes, Fungal ; Humans ; Lectins/*genetics/metabolism ; Mice ; *Mutagenesis, Insertional ; Mutation ; Polymerase Chain Reaction ; Tumor Cells, Cultured ; Virulence/genetics
    Print ISSN: 0036-8075
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  • 153
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    Physician-scientists at risk (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Montgomery, E B Jr -- New York, N.Y. -- Science. 1999 Mar 5;283(5407):1455-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206872" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; Physicians/*economics ; Research/economics ; Research Personnel/*economics ; *Research Support as Topic ; Salaries and Fringe Benefits ; United States
    Print ISSN: 0036-8075
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    Mitigation emerges as major strategy for reducing losses caused by natural disasters. Board of Natural Disasters (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-18
    Description: The International Decade for Natural Disaster Reduction, a United Nations program for the 1990s, focused attention on the increasing losses caused by natural hazards and promoted actions to reduce their impacts. During this period in the United States, disaster managers and other officials increased emphasis on mitigation relative to response and recovery, especially in programs of the Federal Emergency Management Agency. Many other nations and international organizations undertook similar efforts. Beyond the Decade, efforts should focus on improving risk assessments; implementing mitigation strategies; improving technologies supporting warnings and the dissemination of, and response to, warnings; improving the basis for natural disaster insurance; and assisting developing nations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1999 Jun 18;284(5422):1943-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10373106" target="_blank"〉PubMed〈/a〉
    Keywords: Cities ; Developing Countries ; *Disaster Planning/organization & administration/trends ; *Disasters ; International Agencies ; International Cooperation ; Public Policy ; Relief Work ; Risk Assessment ; United Nations ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 155
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    Freedom of information requests (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldwater, W H -- New York, N.Y. -- Science. 1998 Dec 4;282(5395):1823.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9874630" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality/*legislation & jurisprudence ; Financing, Government ; National Institutes of Health (U.S.) ; *Public Policy ; Research/*legislation & jurisprudence ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 156
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    NIH to help fund big physics facilities (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):650.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10454910" target="_blank"〉PubMed〈/a〉
    Keywords: Capital Financing ; Crystallography, X-Ray ; *Financing, Government ; Government Agencies/economics ; National Institutes of Health (U.S.)/*economics ; Proteins/chemistry ; Synchrotrons/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 157
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    Interdisciplinary research at NIH (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J J -- New York, N.Y. -- Science. 1999 Mar 26;283(5410):2018.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206904" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; Peer Review, Research ; *Research ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 158
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    EPA, critics soften stance on pesticidal plants (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hagmann, M -- New York, N.Y. -- Science. 1999 Apr 9;284(5412):249.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10232969" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*legislation & jurisprudence ; *Pesticides ; Plant Diseases ; Plants/*genetics ; United States ; United States Environmental Protection Agency/*legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 159
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    A solution to concerns over public access to scientific data (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, L R -- Hahn, R W -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):535-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, University of California, Irvine 92697, USA. lrcohen@uci.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10447485" target="_blank"〉PubMed〈/a〉
    Keywords: Information Management/*legislation & jurisprudence ; Peer Review, Research ; Periodicals as Topic ; *Public Policy ; Publishing ; Research/*legislation & jurisprudence ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 160
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    Use of chemokine receptors by poxviruses (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-03
    Description: Chemokine receptors serve as portals of entry for certain intracellular pathogens, most notably human immunodeficiency virus (HIV). Myxoma virus is a member of the poxvirus family that induces a lethal systemic disease in rabbits, but no poxvirus receptor has ever been defined. Rodent fibroblasts (3T3) that cannot be infected with myxoma virus could be made fully permissive for myxoma virus infection by expression of any one of several human chemokine receptors, including CCR1, CCR5, and CXCR4. Conversely, infection of 3T3-CCR5 cells can be inhibited by RANTES, anti-CCR5 polyclonal antibody, or herbimycin A but not by monoclonal antibodies that block HIV-1 infection or by pertussis toxin. These findings suggest that poxviruses, like HIV, are able to use chemokine receptors to infect specific cell subtypes, notably migratory leukocytes, but that their mechanisms of receptor interactions are distinct.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lalani, A S -- Masters, J -- Zeng, W -- Barrett, J -- Pannu, R -- Everett, H -- Arendt, C W -- McFadden, G -- New York, N.Y. -- Science. 1999 Dec 3;286(5446):1968-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The John P. Robarts Research Institute and Department of Immunology, The University of Western Ontario, London, Ontario N6G 2V4, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10583963" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; Antibodies/immunology ; Benzoquinones ; Cell Line ; Cercopithecus aethiops ; Chemokine CCL5/pharmacology ; Gene Expression ; Humans ; Lactams, Macrocyclic ; Mice ; Myxoma virus/genetics/*metabolism ; Pertussis Toxin ; Quinones/pharmacology ; Receptors, CCR1 ; Receptors, CCR5/immunology/metabolism ; Receptors, CXCR4/metabolism ; Receptors, Chemokine/*metabolism ; Receptors, Virus/*metabolism ; Rifabutin/analogs & derivatives ; Signal Transduction ; Tumor Cells, Cultured ; Virulence Factors, Bordetella/pharmacology ; beta-Galactosidase/biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 161
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    Rice genome. U.S. adds $12 million to global sequencing push (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, D -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10532883" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; *Genome, Plant ; International Cooperation ; Japan ; Oryza/*genetics ; Sequence Analysis, DNA/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 162
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    Groups sue to tighten oversight of rodents (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):767, 769.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10049111" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; Animal Rights/*legislation & jurisprudence ; Animal Testing Alternatives ; Animal Welfare/*legislation & jurisprudence ; Animals ; *Animals, Laboratory ; Birds ; Budgets ; Federal Government ; *Government Regulation ; *Rodentia ; United States ; United States Department of Agriculture/economics/*legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 163
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    Academic sequencers challenge Celera in a sprint to the finish (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1999 Mar 19;283(5409):1822-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206879" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; Foundations ; Great Britain ; *Human Genome Project/economics ; Humans ; National Institutes of Health (U.S.)/economics ; *Research Support as Topic ; *Sequence Analysis, DNA/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 164
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    Fruit fly researchers sign pact with Celera (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):767.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10049110" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotechnology ; Drosophila melanogaster/*genetics ; *Genome ; National Institutes of Health (U.S.) ; *Private Sector ; *Public Sector ; *Sequence Analysis, DNA ; United States ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 165
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    Likelihood of NIH extramural funding (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, H G -- Vesell, E S -- New York, N.Y. -- Science. 1999 Sep 10;285(5434):1674-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10523182" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; National Institutes of Health (U.S.)/*economics ; Peer Review, Research ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 166
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    Ag biotech moves to mollify its critics (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, M -- New York, N.Y. -- Science. 1999 Nov 26;286(5445):1666-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610558" target="_blank"〉PubMed〈/a〉
    Keywords: *Biotechnology/economics ; Commerce ; Crops, Agricultural/adverse effects/*genetics ; Developing Countries ; Europe ; Food Labeling ; *Genetic Engineering ; *Plants, Genetically Modified/adverse effects ; Public Opinion ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 167
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    Facing fear of biotechnology (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beachy, R N -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):335.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10438293" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*methods ; *Biotechnology ; *Crops, Agricultural/genetics ; *Food ; *Genetic Engineering ; Mass Media ; United States ; United States Department of Agriculture ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 168
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    Groups race to sequence and identify New York virus (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, M -- New York, N.Y. -- Science. 1999 Oct 8;286(5438):206-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bird Diseases/epidemiology/virology ; Birds ; Centers for Disease Control and Prevention (U.S.) ; *Disease Outbreaks/veterinary ; Encephalitis Virus, St. Louis/classification/genetics/isolation & purification ; *Encephalitis Viruses/classification/genetics/isolation & purification ; Encephalitis Viruses, Japanese/classification/genetics/isolation & purification ; Encephalitis, Arbovirus/*epidemiology/transmission/veterinary/*virology ; Genome, Viral ; Humans ; Mosquito Control ; New York City/epidemiology ; Sequence Analysis ; United States ; United States Department of Agriculture ; West Nile virus/classification/genetics/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 169
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    From junk bond king to cancer crusader (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, E -- New York, N.Y. -- Science. 1999 Feb 19;283(5405):1100-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10075566" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic ; *Famous Persons ; *Foundations ; History, 20th Century ; Humans ; Male ; *Prostatic Neoplasms/therapy ; *Research Support as Topic ; Tissue Banks ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 170
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    Varmus to leave NIH in December to run Sloan-Kettering (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Oct 15;286(5439):382-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577194" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/*organization & administration ; Cancer Care Facilities/*organization & administration ; History, 20th Century ; National Institutes of Health (U.S.)/economics/*organization & administration ; New York City ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 171
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    NIH's online publishing venture ready for launch (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Sep 3;285(5433):1466.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10498524" target="_blank"〉PubMed〈/a〉
    Keywords: *Internet ; *National Institutes of Health (U.S.) ; Peer Review, Research ; Periodicals as Topic ; *Publishing ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 172
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    Retinoblastoma treatment (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurwitz, R L -- Brenner, M K -- Poplack, D G -- Horowitz, M C -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):663-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10454919" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Clinical Protocols ; Clinical Trials, Phase I as Topic ; *Genetic Therapy ; Humans ; National Institutes of Health (U.S.) ; Peer Review, Research ; Public Policy ; Retinal Neoplasms/*therapy ; Retinoblastoma/*therapy ; United States
    Print ISSN: 0036-8075
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  • 173
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    Science supporter John Porter to leave Congress (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Oct 22;286(5440):651.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577211" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Financing, Government ; Government ; History, 20th Century ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 174
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    Human genome project. Commercial firms win U.S. sequencing funds (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):310.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10438288" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; Human Genome Project/*economics ; Humans ; National Institutes of Health (U.S.)/*economics ; Private Sector ; *Research Support as Topic ; Sequence Analysis, DNA/*economics ; United States ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 175
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    Varmus circulates proposal for NIH-backed online venture (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Apr 30;284(5415):718.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10336388" target="_blank"〉PubMed〈/a〉
    Keywords: *Internet ; *National Institutes of Health (U.S.) ; Peer Review, Research ; *Publishing ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 176
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    E-biomed morphs to E-biosci, focus shifts to reviewed papers (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Aug 6;285(5429):810-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10454924" target="_blank"〉PubMed〈/a〉
    Keywords: Copyright ; Costs and Cost Analysis ; *Internet/economics ; *National Institutes of Health (U.S.) ; *Peer Review, Research ; Periodicals as Topic ; *Publishing/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Investing in the World Health Organization (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bloom, B R -- Bloom, D E -- Cohen, J E -- Sachs, J D -- New York, N.Y. -- Science. 1999 May 7;284(5416):911.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10357669" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Financing, Government ; United States ; World Health Organization/*economics/organization & administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 178
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    Ethicists back stem cell research, White House treads cautiously (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):502.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10447474" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Bioethics ; *Embryo Research ; Embryo, Mammalian/*cytology ; Ethics Committees ; Federal Government ; Financing, Government ; Guidelines as Topic ; Humans ; National Institutes of Health (U.S.) ; *Public Policy ; *Research/legislation & jurisprudence ; Research Support as Topic ; *Stem Cells ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 179
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    NIMH to screen studies for science and human risks (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1999 Jan 22;283(5401):464-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9988644" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Beneficence ; Bioethics ; Clinical Protocols/*standards ; Clinical Trials as Topic/*standards ; *Ethical Review ; Federal Government ; Government Regulation ; Human Experimentation ; Humans ; *Mental Disorders/drug therapy ; *Mentally Ill Persons ; *National Institute of Mental Health (U.S.) ; Research/*standards ; Risk Factors ; United States ; Withholding Treatment
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 180
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    Mouse genome added to sequencing effort (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 1999 Oct 8;286(5438):211.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577185" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Financing, Government ; *Genome ; Human Genome Project ; Mice/*genetics ; National Institutes of Health (U.S.)/economics ; *Sequence Analysis, DNA/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 181
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    Database protection: is it broken and should we fix it? (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maurer, S M -- Scotchmer, S -- New York, N.Y. -- Science. 1999 May 14;284(5417):1129-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10366346" target="_blank"〉PubMed〈/a〉
    Keywords: Copyright ; Databases, Factual/economics/*legislation & jurisprudence ; European Union ; Intellectual Property ; Privatization ; Software ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 182
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    Public access to data (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, M S -- New York, N.Y. -- Science. 1999 Feb 19;283(5405):1114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10075568" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government/legislation & jurisprudence ; Information Management/*legislation & jurisprudence ; Intellectual Property ; *Public Policy ; Publishing/*legislation & jurisprudence ; Research/legislation & jurisprudence ; Research Support as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 183
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    More regulation of rodents (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trull, F L -- Rich, B A -- New York, N.Y. -- Science. 1999 May 28;284(5419):1463.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10383321" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; Animal Welfare/economics/*legislation & jurisprudence ; Animals ; *Animals, Laboratory ; *Birds ; Costs and Cost Analysis ; Federal Government ; *Government Regulation ; *Rodentia ; United States ; United States Department of Agriculture/economics/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 184
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    Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-05
    Description: Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A combination of two phenotype-based screens, one based on a specific posttranslational modification, the other visualizing microtubules and chromatin, was used to identify compounds that affect mitosis. One compound, here named monastrol, arrested mammalian cells in mitosis with monopolar spindles. In vitro, monastrol specifically inhibited the motility of the mitotic kinesin Eg5, a motor protein required for spindle bipolarity. All previously known small molecules that specifically affect the mitotic machinery target tubulin. Monastrol will therefore be a particularly useful tool for studying mitotic mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayer, T U -- Kapoor, T M -- Haggarty, S J -- King, R W -- Schreiber, S L -- Mitchison, T J -- CA78048/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Oct 29;286(5441):971-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, and Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Thomas_Mayer@hms.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10542155" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/drug effects ; Animals ; Cattle ; Cell Line ; Cytoskeleton/drug effects ; Golgi Apparatus/drug effects ; Kinesin/*drug effects ; Microtubules/drug effects ; Mitosis/*drug effects ; Molecular Motor Proteins/drug effects ; Phenotype ; Phosphoproteins/metabolism ; Protein Processing, Post-Translational ; Pyrimidines/*pharmacology ; RNA-Binding Proteins/metabolism ; Spindle Apparatus/*drug effects ; Thiones/*pharmacology ; Tumor Cells, Cultured ; Xenopus ; *Xenopus Proteins
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 185
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    Policing of science. A misconduct definition that finally sticks (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1999 Oct 15;286(5439):391.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577196" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Plagiarism ; *Scientific Misconduct ; United States ; United States Dept. of Health and Human Services
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 186
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    Data disclosure. Congress votes down delay in access law (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):511.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10447479" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; Financing, Government/legislation & jurisprudence ; Government ; Information Management/*legislation & jurisprudence ; Intellectual Property ; Publishing ; Research/legislation & jurisprudence ; Research Support as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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  • 187
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    Panel discounts implant disease risk (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1999 Jun 25;284(5423):2065-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10409056" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Implantation ; Breast Implants/*adverse effects ; Connective Tissue Diseases/*etiology ; Female ; Humans ; *Institute of Medicine (U.S.) ; Neoplasms/*etiology ; Research ; Risk Factors ; Silicone Gels/*adverse effects ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 188
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    Privacy in genetics research (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuller, B P -- Kahn, M J -- Barr, P A -- Biesecker, L -- Crowley, E -- Garber, J -- Mansoura, M K -- Murphy, P -- Murray, J -- Phillips, J -- Rothenberg, K -- Rothstein, M -- Stopfer, J -- Swergold, G -- Weber, B -- Collins, F K -- Hudson, K L -- New York, N.Y. -- Science. 1999 Aug 27;285(5432):1359-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉barbaraf@exchange.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10490410" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethics ; *Confidentiality ; *Disclosure ; Ethics Committees, Research ; Federal Government ; *Genetic Privacy ; *Genetic Research ; *Genetics, Medical ; Government Regulation ; Humans ; Informed Consent ; Privacy ; Research/legislation & jurisprudence/*standards ; *Research Subjects ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 189
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    Physician-scientists at risk (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rockey, D -- New York, N.Y. -- Science. 1999 Mar 5;283(5407):1455.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206870" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; *Physicians/statistics & numerical data/trends ; Research/*manpower ; *Research Personnel ; Research Support as Topic ; Training Support ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 190
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    Expert testimony. Project offers judges neutral science advice (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1999 Jun 4;284(5420):1600.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10383331" target="_blank"〉PubMed〈/a〉
    Keywords: Conflict of Interest ; *Expert Testimony ; Pilot Projects ; *Societies, Scientific ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 191
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    Scientific misconduct. ORI report tracks gun-shy feds (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1999 May 7;284(5416):901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10357668" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; Disclosure ; Federal Government ; *Government Regulation ; *Scientific Misconduct ; United States ; *United States Office of Research Integrity ; *Universities ; Whistleblowing
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  • 192
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    Plan for divulging raw data eases fears (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1999 Feb 12;283(5404):914-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10075555" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; Financing, Government ; Information Management/*legislation & jurisprudence ; *Public Policy ; *Publishing ; Research/*legislation & jurisprudence ; Research Support as Topic/legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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  • 193
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    Scientific misconduct. EMF researcher made up data, ORI says (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vergano, D -- New York, N.Y. -- Science. 1999 Jul 2;285(5424):23, 925.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10428693" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium Signaling/*radiation effects ; Electromagnetic Fields/*adverse effects ; Publishing ; *Scientific Misconduct ; United States ; United States Office of Research Integrity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 194
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    Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-24
    Description: The human adenovirus serotype 5 (Ad5) is used widely for applications in human gene therapy. Cellular attachment of Ad5 is mediated by binding of the carboxyl-terminal knob of its fiber coat protein to the Coxsackie adenovirus receptor (CAR) protein. However, Ad5 binding to CAR hampers the development of adenovirus vectors capable of specifically targeting (diseased) tissues or organs. Through sequence analysis and mutagenesis, a conserved receptor-binding region was identified on the side of three divergent CAR-binding knobs. The feasibility of simultaneous CAR ablation and redirection of an adenovirus to a new receptor is demonstrated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roelvink, P W -- Mi Lee, G -- Einfeld, D A -- Kovesdi, I -- Wickham, T J -- New York, N.Y. -- Science. 1999 Nov 19;286(5444):1568-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research and Development, GenVec Inc., 65 West Watkins Mill Road, Gaithersburg, MD 20879, USA. genecloner@genvec.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10567265" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/*chemistry/metabolism ; Amino Acid Sequence ; Binding Sites ; Capsid/*chemistry/genetics/*metabolism ; *Capsid Proteins ; Cell Line ; Conserved Sequence ; Coxsackie and Adenovirus Receptor-Like Membrane Protein ; Genetic Vectors ; Humans ; Models, Molecular ; Mutagenesis, Site-Directed ; Point Mutation ; Protein Conformation ; Protein Structure, Secondary ; Receptors, Virus/*metabolism ; Sequence Deletion ; Transfection ; Tumor Cells, Cultured
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 195
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    FDA report scores chimp research lab (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1999 Nov 12;286(5443):1269, 1271.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610531" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; *Animal Welfare ; Animals ; Animals, Laboratory ; Federal Government ; Foundations/*standards ; *Government Regulation ; *Pan troglodytes ; Research/*standards ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
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  • 196
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    AAAS statement on the Kansas State Board of Education decision on the education of students in the science of evolution and cosmology. American Association for the Advancement of Science Board of Directors (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1999 Nov 12;286(5443):1297.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610533" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/education ; Biological Evolution ; Kansas ; Science/*education ; Societies, Scientific ; United States
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  • 197
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    AIDS research chief bows out (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Oct 10;278(5336):218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9340767" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; History, 20th Century ; National Institutes of Health (U.S.)/*organization & administration ; Research ; United States
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  • 198
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    NCI reverses one expert panel, sides with another (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):27-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122702" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Breast Neoplasms/*prevention & control/radiography ; Consensus Development Conferences, NIH as Topic ; Female ; Humans ; *Mammography ; *Mass Screening ; Middle Aged ; *National Institutes of Health (U.S.) ; Randomized Controlled Trials as Topic ; Risk Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 199
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    Human genome agreements (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorimer, B G -- New York, N.Y. -- Science. 1997 Jan 31;275(5300):601-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9019811" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Base Sequence ; DNA, Complementary/*genetics ; Databases, Factual ; *Genome, Human ; Humans ; Intellectual Property ; Publishing ; Research Support as Topic ; Sequence Analysis, DNA ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 200
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    Key player: Kevin Kinsella. The industry's top showman (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):773.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036538" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/history/*organization & administration ; Genetics, Medical/history/*organization & administration ; Genome, Human ; History, 20th Century ; Humans ; Industry/history/organization & administration ; Molecular Biology/history/*organization & administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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