Publication Date:
1994-04-15
Description:
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (p16) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kamb, A -- Gruis, N A -- Weaver-Feldhaus, J -- Liu, Q -- Harshman, K -- Tavtigian, S V -- Stockert, E -- Day, R S 3rd -- Johnson, B E -- Skolnick, M H -- CA-48711/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1994 Apr 15;264(5157):436-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Myriad Genetics, Inc., Salt Lake City, UT 84108.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8153634" target="_blank"〉PubMed〈/a〉
Keywords:
Base Sequence
;
Carrier Proteins/*genetics
;
Cell Cycle
;
Chromosomes, Human, Pair 9
;
Cosmids
;
Cyclin-Dependent Kinase 4
;
Cyclin-Dependent Kinase Inhibitor p16
;
*Cyclin-Dependent Kinases
;
Exons
;
Gene Deletion
;
*Genes, Tumor Suppressor
;
Humans
;
Introns
;
Melanoma/*genetics
;
Molecular Sequence Data
;
Mutation
;
Neoplasms/*genetics
;
Protein Kinase Inhibitors
;
*Proto-Oncogene Proteins
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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