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  • Artikel  (162)
  • RFLP  (66)
  • taxonomy  (65)
  • hypertension
  • Springer  (162)
  • Annual Reviews
  • Blackwell Publishing Ltd
  • 2005-2009
  • 1990-1994  (106)
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  • Springer  (162)
  • Annual Reviews
  • Blackwell Publishing Ltd
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  • 2005-2009
  • 1990-1994  (106)
  • 1980-1984  (56)
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  • 1
    Digitale Medien
    Digitale Medien
    Comparisons between the inorganic content of healthy and hypertensive rat tissues by inductively coupled plasma-mass spectrometry (1994)
    Springer
    BioMetals 7 (1994), S. 155-162 
    Details
    ISSN: 1572-8773
    Schlagwort(e): hypertension ; inductively coupled plasma-mass spectrometry ; inorganic content ; rat tissues
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The inorganic contents of bone, brain, erythrocyte, heart, kidney cortex, kidney medulla, liver, lung, muscle and plasma from spontaneously hypertensive rats were compared with those of the same tissues from healthy Sprague-Dawley rats. A general inductively coupled plasma-mass spectrometry method developed for multi-element determinations of most of the elements present in biological tissues was used. Variations were found not only for major elements, as expected, but also for many trace elements in several tissues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00140486
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  • 2
    Digitale Medien
    Digitale Medien
    Synonymy of the yeast generaWingea andDebaryomyces (1994)
    Springer
    Antonie van Leeuwenhoek 66 (1994), S. 337-342 
    Details
    ISSN: 1572-9699
    Schlagwort(e): Debaryomyces ; phylogeny ; ribosomal RNA ; taxonomy ; Wingea ; yeasts
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Extent of divergence in partial nucleotide sequences from large and small subunit ribosomal RNAs was used to estimate the evolutionary relationship between the generaWingea andDebaryomyces. These data showed the monotypic genusWingea to be congeneric withDebaryomyces, and it is proposed to transferW. robertsii toDebaryomyces.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00882770
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  • 3
    Digitale Medien
    Digitale Medien
    Self-incompatibility is codominant in intraspecific hybrids of self-compatible and self-incompatible Lycopersicon peruvianum and L. hirsutum based on protein and DNA marker analysis (1994)
    Springer
    Sexual plant reproduction 7 (1994), S. 297-302 
    Details
    ISSN: 1432-2145
    Schlagwort(e): Gametophytic self incompatibilityself-compatibility ; Lycopersicon peruvianum Lycopersicon hirsutum ; S-associated proteins ; RFLP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Self-compatibility was investigated separately in two species of tomato, Lycopersicon peruvianum and L. hirsutum. The codominant expression of self-compatibility (SC)/self incompatibility (SI) was established using intraspecific hybrids of SC and SI hybrids. In SC L. peruvianum, a major stylar protein of approximately 29 kDa cosegregates with self-compatibility in the progeny of SC/SI hybrids. The SC/SI hybrids are self-fertile, but only partially so, since the SI allele present in the hybrids is capable of eliminating certain genotypes in the resultant progeny. In L. hirsutum, the majority of hybrids between one accession of SI L. hirsutum f. hirsutum and one of SC L. hirsutum f. glabratum are self-fertile. Analysis of the progeny revealed that the SC and SI alleles are codominant in this species as well. A protein product for the SC allele is not obvious in style extracts of L. hirsutum f. glabratum. Segregating progeny from SC/SI hybrids of L. hirsutum were used to map the S locus against five RFLP markers on chromosome 1, and estimated map distances are given. In addition, evidence is presented that indicates that one of the DNA markers, CD15, is duplicated in L. hirsutum f. glabratum, and the duplication is not linked to the S locus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00227713
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  • 4
    Digitale Medien
    Digitale Medien
    Statistical evaluation of circadian blood pressure rhythm during isradipine long-term therapy (1994)
    Springer
    European journal of clinical pharmacology 46 (1994), S. 119-122 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Isradipine ; Fourier ; rhythm ; hypertension ; diurnal blood pressure rhythm
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract In this study, using the two-step truncated Fourier series with four harmonics, we analysed the diurnal blood pressure profile in 13 mild-moderate essential hypertensive patients during isradipine long-term therapy. Circadian parameters such as the amplitudes and phases of the four harmonics and the overall amplitude and phase were obtained from the model. The total duration of the study was 26 weeks. Ambulatory blood pressure was measured at 15-min, intervals using a Takeda TM 2420 device after 2 weeks of placebo and after 6 and 26 weeks of isradipine (5 mg daily) respectively. After 6 and 26 weeks therapy the blood pressure values showed a significant decrease, although the daily blood pressure curves obtained from Fourier analysis showed that the circadian rhythm was not altered by isradipine treatment. Both the night/day differences and the overall amplitude/acrophases were statistically significant at 0,6 and 26 weeks. According the nocturnal blood pressure fall, we found that long-term therapy with isradipine increased the number of patients with nocturnal blood pressure fall and reducing the early morning blood pressure rise. In conclusion, the two-step method Fourier analysis represents a novel and useful statistical approach to evaluate the presence of a significant diurnal blood pressure rhythm and to provide the circadian parameters of the 24-h blood pressure profile during pharmacological therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199873
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  • 5
    Digitale Medien
    Digitale Medien
    Variability in genome organization of the zygomycete Parasitella parasitica (1994)
    Springer
    Current genetics 26 (1994), S. 456-460 
    Details
    ISSN: 1432-0983
    Schlagwort(e): Parasitella parasitica ; Zygomycetes ; RAPD ; PCR ; RFLP ; Electrophoretic karyotype ; Molecular taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract In addition to conventional methods for the identification of fungi, molecular techniques at the DNA level are increasingly being employed. In order to check the validity of such experimental approaches, we have analyzed the well-defined species Parasitella parasitica, which belongs to the family Mucoraceae (Mucorales, Zygometes). The seven strains of this species, which are available from international strain collections, were analyzed by several molecular methods: restriction fragment length polymorphism analysis (RFLP), the random primer-dependent polymerase chain reaction (RAPD-PCR), and electrophoretic karyotyping. Unexpectedly, these strains are highly diverse at the molecular level. By these techniques they can be divided consistently into two different groups. Nevertheless, all seven strains belong to a single species. They show no morphological differences and sexual spores (zygospores) were found in all possible combinations either within or between the two groups. Southern-blot analysis of genomic DNA of all P. parasitica strains with RAPD-PCR-derived labelled probes shows the existence of repetitive elements characteristic for only one group of P. parasitica. In addition, chromosome sizes, which were separated by rotating-field electrophoresis, were highly divergent, and ranged from 3 to 6.5 Mb in one group and between 2 and 4.5 Mb in the other. The RAPD-PCR patterns also discriminate both groups of P. parasitica. However, they are very similar if strains of a single group are compared. Therefore, we propose that the determination of fungal species by molecular techniques should be vetted at least by morphological and physiological parameters and, whenever possible, by mating experiments.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00309934
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  • 6
    Digitale Medien
    Digitale Medien
    Relationship between the cardiovascular effects and steady-state kinetics of clonidine in hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 309-313 
    Details
    ISSN: 1432-1041
    Schlagwort(e): clonidine ; hypertension ; therapeutic window ; steady state concentration ; pharmacokinetics ; cardiovascular effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Clonidine was given orally as monotherapy in increasing daily doses from 3.1 to 25.7 µg/kg to patients with essential hypertension (n=6). When a steady state concentration in plasma was reached at each dose level, the blood pressure (BP) and heart rate were measured during a dosage interval. Effect time — plasma concentration data were submitted to nonlinear regression analysis, which showed that the observed BP effects could be dissociated into depressor and pressor components. A window for the antihypertensive effect was established. At a plasma clonidine concentration of 0.65±0.07 ng/ml 50% of the maximal depressor effect was found, and it was only separated by a factor of 2 from the half maximal pure pressor concentration in plasma. No relationship between the change in heart rate and the plasma clonidine was observed. The findings strengthen the importance of close monitoring of clonidine therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00548760
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  • 7
    Digitale Medien
    Digitale Medien
    Effect of oxprenolol and metoprolol on serum lipid concentration (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 331-334 
    Details
    ISSN: 1432-1041
    Schlagwort(e): metoprolol ; oxprenolol ; hypertension ; beta-blockers ; HDL-cholesterol ; intrinsic sympathomimetic activity ; cardioselectivity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The aim of the present study was to evaluate whether a reduction in HDL-cholesterol is peculiar to non cardioselective beta blockers or whether it is also produced by cardioselective beta1-blockers. 16 patients with primary arterial hypertension on a balanced isocaloric diet were given oxprenolol 120 to 240 mg/day or metoprolol 100 to 200 mg/day in a random cross-over study. No significant change was observed after either treatment in fasting blood glucose, serum total cholesterol and triglycerides. HDL-cholesterol concentration was significantly decreased on metoprolol, from 41 to 36 mg/dl (p〈0.05), while oxprenolol did not affect it at all. The difference might depend on intrinsic sympathomimetic activity which is possessed by oxprenolol and which metoprolol lacks.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00548763
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  • 8
    Digitale Medien
    Digitale Medien
    Pafenolol, a new β1-selective blocking agent, in mild hypertension. Result of an inpatient study and a subsequent outpatient follow-up (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 549-553 
    Details
    ISSN: 1432-1041
    Schlagwort(e): pafenolol ; hypertension ; antihypertensive therapy ; beta1-blocking agent ; exercise tests ; plasma levels
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Pafenolol, a new selective adrenergic beta1-blocking agent, has been tested for the first time in 6 hypertensive patients. After single oral doses of pafenolol 25 to 100 mg, there was a marked reduction in heart rate and systolic blood pressure during exercise tests. These effects were dose dependent. A significant positive correlation was found between the reduction in heart rate during exercise and the plasma level of pafenolol 5 hours after drug intake (correlation coefficient r=0.94). Side effects were mild and seemed to be dose dependent. It is concluded that this new beta1-blocking agent was effective in reducing blood pressure and was well tolerated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543483
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  • 9
    Digitale Medien
    Digitale Medien
    Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 687-693 
    Details
    ISSN: 1432-1041
    Schlagwort(e): etozolin ; ozolinone ; furosemide ; hypertension ; renin ; catecholamines ; chronic renal failure ; steady state kinetics ; plasma levels
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect on urinary electrolyte excretion, renin release and plasma norepinephrine of single oral doses of 400 mg etozolin (E) and of 40 mg furosemide (F) were studied in hypertensive patients with normal (n=6) and impaired kidney function (n=6). E caused a marked saluresis up to 24 hours, showing its long duration of action. F, however, displayed a brief, brisk peak diuresis, followed by a rebound from the 4th to the 24th hours. The brisk peak diuresis induced by F was associated with pronounced release of renin, almost twice that induced by E. In chronic renal failure the renin release in relation to the magnitude of the diuresis was increased, i.e. the sensitivity of these patients to changes in water homeostasis was increased. E and F stimulated the sympathetic system to roughly the same extent. Patients with essential hypertension had higher plasma levels of norepinephrine than hypertensive patients with chronic renal failure. In addition, hypertensive patients with normal renal function (n=4) and varying degrees of renal impairment (n=11) were also given 400 mg daily for 2 weeks. Effects on blood pressure and electrolyte homeostasis were monitored, as well as the plasma kinetics of metabolite I, ozolinone. At the end of the 2 week treatment E had significantly lowered systolic (−12 mm Hg) and diastolic (−9 mm Hg) blood pressure, and had produced a significant loss of body weight, without altering plasma electrolytes or blood chemistry. There was no accumulation of the effective metabolite ozolinone under conditions of severe impairment of kidney function. It is concluded that E can effectively control high blood pressure in patients with normal and impaired kidney function. Its effective metabolite ozolinone did not accumulate in chronic renal failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541926
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  • 10
    Digitale Medien
    Digitale Medien
    Once daily indapamide in the treatment of the elderly and young hypertensive (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 397-405 
    Details
    ISSN: 1432-1041
    Schlagwort(e): indapamide ; hypertension ; cardiovascular reflexes ; diuretic effect ; blood pressure variability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Nine elderly and 11 young hypertensives underwent continuous ambulatory monitoring of blood pressure (BP), assessment of cardiovascular reflexes and M-mode echocardiography as hospital in-patients prior to treatment with once-daily indapamide (2.5 mg). They were followed as out-patients for 4 months during which time casual BP was measured at monthly intervals. The patients were then readmitted to hospital and studied using the same protocol under similar standardised conditions. The results showed that indapamide reduced casual and ambulatory BP in both young and elderly although the most marked effect was seen on systolic BP. Assessment of cardiovascular reflexes indicates that at least part of the hypotensive action of indapamide is due to a diuretic effect. Treatment with indapamide has comparable results on both young and elderly.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00549585
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  • 11
    Digitale Medien
    Digitale Medien
    Long-term effects of captopril on renal function in hypertensive patients (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 315-323 
    Details
    ISSN: 1432-1041
    Schlagwort(e): captopril ; hypertension ; glomerular filtration ; para-aminohippuric acid ; renal function ; severe drug reaction ; nephrotic syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of captopril up to 450 mg/day on blood pressure and renal function were investigated during sustained treatment of 10 patients whose severe hypertension had not responded to previous therapy. All the patients were kept on diuretics and most of them on β-blockers, too. A control determination of glomerular filtration rate (GFR) and para-aminohippuric acid clearance (CPAH) was performed during the prior treatment. The effect of the addition (or substitution) of captopril were assessed after an average of 25 days (short-term) and 26 weeks (long-term). Short-term treatment produced a 15.5% decrease in mean blood pressure and interindividually variable effects on renal function. On average GFR was somewhat lower and CPAH slightly higher than the control values (not significant). This pattern is quite similar to the effects of most other antihypertensive drugs. On long-term therapy GFR rose by a mean of 9% (NS) and CPAH by 17% (p〈0.02). However, in a patient who developed a captopril-induced nephrotic syndrome, GFR dropped to 56% and CPAH to 50% of the control values. In another patient a transient rise in serum creatinine accompanied a severe drug reaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00548761
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  • 12
    Digitale Medien
    Digitale Medien
    A unique sequence located downstream from the rice mitochondrialatp6 may cause male sterility (1994)
    Springer
    Current genetics 25 (1994), S. 52-58 
    Details
    ISSN: 1432-0983
    Schlagwort(e): Cytoplasmic male sterility ; Antisense RNA ; RFLP ; Cybrids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Asymmetric cell-fusion of the japonica cultivar ofOryza sativa (rice) with cytoplasmic-male-sterile (CMS) plants bearing cytoplasm derived from Chinsurah Boro II, resulted in two classes of cytoplasmic hybrids (cybrids), fertile and CMS. Southern-blot analysis of the mitochondrial DNA (mtDNA) indicates recombination events around a number of genes; however, the appearance of the CMS character is tightly correlated to reorganization around theatp6 gene, suggesting recombination downstream from theatp6 gene is involved in CMS. The nucleotide sequence downstream fromatp6 contains a pseudogene which was probably created by recombination of the mitochondrial genome. Sense and antisense transcripts of the downstream region ofatp6 were found in CMS-and restored CMS (fertile)-lines, but not in the normal (fertile) line. In the CMS line, several antisense transcripts of theatp6 gene were also found. However, in the restored line which contains a nuclear-encoded gene,Rf-1, the levels of these transcripts were lower than in the CMS line. These results suggest abnormal transcripts of theatp6 gene produced in the antisense direction may be involved in CMS, and that products of the nuclear-encoded restorer gene may reduce abnormal transcription in this region of the mitochondrial genome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00712968
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  • 13
    Digitale Medien
    Digitale Medien
    Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 13-17 
    Details
    ISSN: 1432-1041
    Schlagwort(e): beta-blocking drugs ; insulin sensitivity ; pancreatic beta-cell function ; hypertension ; propranolol ; atenolol ; insulin secretion ; plasma GIP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effects of two beta-blocking drugs on endogenous insulin secretion and insulin sensitivity were investigated in a double blind cross-over study in 13 hypertensive patients. The patients were randomly allocated to each of three 2-week treatment periods with propranolol 80 mg b.i.d., atenolol 50 mg b.i.d. and placebo b.i.d. Endogenous insulin secretion was assessed by measuring serum insulin and C-peptide before and 6 min after iv administration of glucagon; insulin sensitivity was determined by measuring insulin binding to erythrocytes, and as the glucose disappearance rate (KITT) after i.v. insulin. Fasting concentrations of serum free fatty acids (S-FFA) and plasma gastric inhibitory polypeptide (P-GIP) were also recorded during the three study periods. Both propranolol and atenolol reduced blood pressure, heart rate and S-FFA concentrations compared to placebo, and all patients showed measurable plasma concentrations of propranolol and atenolol. The results can be considered representative, therefore, of clinical beta-blockade. The two drugs did not significantly influence the fasting blood glucose level. There was an increase in fasting and glucagon-stimulated serum C-peptide concentration during propranolol therapy compared with placebo (p=0.037 and p=0.030, respectively), although this was not reflected by a significant change in serum insulin. Propranolol and atenolol did not significantly influence insulin binding to erythrocytes, but they clearly reduced the glucose disappearance rate KITT was compared to placebo (p=0.0036 and p=0.0003, respectively). The findings support the view that beta-blocking drugs can influence glucose metabolism by mechanisms other than inhibition of endogenous insulin secretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00546701
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  • 14
    Digitale Medien
    Digitale Medien
    Should the acetylator phenotype be determined when prescribing hydralazine for hypertension? (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 39-42 
    Details
    ISSN: 1432-1041
    Schlagwort(e): acetylator phenotype ; hydralazine response ; hypertension ; blood pressure control ; lupus syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The role of acetylator phenotype in determining the response to hydralazine when it was added to diuretic and β-blocker at doses not exceeding 200 mg daily was examined in 57 hypertensive patients. 81% of rapid acetylators needed 200 mg hydralazine daily compared to 38% of slow acetylators (p〈0.01). Despite higher doses of hydralazine the blood pressure was controlled in only 27% of rapid acetylators compared to 65% of slow acetylators (p〈0.02). The relation of acetylator phenotype to blood pressure response was statistically independent of initial blood pressure, age, sex, body weight and serum creatinine (p〈0.005). Current recommendations on hydralazine dosage are unsatisfactory for the 40% of hypertensive patients who are rapid acetylators. We suggest measurement of the acetylator phenotype in patients who respond incompletely to 200 mg hydralazine daily. About 70% of these patients will be rapid acetylators in whom the dose of hydralazine can be increased safely.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00546706
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  • 15
    Digitale Medien
    Digitale Medien
    Comparison of methods to detect side-effect on clinical application of chloranolol, a beta-adrenergic receptor inhibitor (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 555-562 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Tobanum® ; beta-blocker ; chloranolol ; hypertension ; angina pectoris ; arrhythmia ; detection methods
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The incidence of side-effects on administration of chloranolol (Tobanum®), a beta-adrenergic receptor blocking drug, to 2066 patients with hypertension, angina pectoris or arrhythmias was measured by three different methods. In 600 patients in an efficacy trial (Group 1) both spontaneously reported complaints and objective signs were tabulated. A side effect — directed method, utilising a questionnaire containing a list of possible side-effects was also used, with the questionnaire being completed by the physician. 35 questions referred to anticipated and other side-effects. The trial was performed in two groups: in 537 patients a placebo was also given (Group 2), and in another set of 929 patients (Group 3) the questionnaire inquiry was performed uncontrolled, without placebo. All three groups were comparable in their distribution of sexes, ages and diagnoses, the mean daily dose of chloranolol its use alone or in combination, and in a similar duration of treatment. 55% of all patients received chloranolol therapy for a period of more than 3 months. The ratio of in- and outpatients was 1:5. The side-effect incidence was independent of the age and sex of the patients and of the dose of chloranolol. The incidence was also unaffected whether chloranolol was used alone or in combination. The number of side-effects differed markedly between the three groups, their ratio was 1:10:24 in Groups 1, 2 and 3. Two-thirds of the side-effects subsided spontaneously within 1 month of their onset. The duration of the side-effects varied according to their character: cardiorespiratory side-effects were of the shortest duration and those affecting the central nervous system were the most enduring. The appreciable differences in incidence could be attributed to the methods of collection of the data. It has been stated that placebo controlled trials using a detailed questionnaire are the most suitable for estimating the incidence of side-effects; recording side-effects spontaneously reported by patients are insufficiently sensitive, and uncontrolled trials using a questionnaire have been shown to be too sensitive. The revealed incidence of side effects leading to interruption of treatment is less affected by the method chosen. In 100 patients (4.8%) therapy had to be suspended because of the side-effects of chloranolol (Group 1: 1%, Group 2: 6.20%, Group 3: 6.6%). Comparison of the incidence of cessation of therapy due to side-effects did not show an appreciable difference between the various beta-adrenergic receptor blocking agents, including chloranolol.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543484
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  • 16
    Digitale Medien
    Digitale Medien
    Propranolol vs metoprolol vs labetalol: A comparative study in essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 1-6 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; beta-blockers ; propranolol ; metoprolol ; labetalol ; exercise ; heart rate ; blood pressure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In a double blind, within patient investigation of twenty-four patients (nineteen males and five females) with a mean age of 46.3 years (SD 10.9 years) with mild to moderate essential hypertension a comparison between equipotent beta-blocking doses of propranolol, metoprolol and labetalol was carried out. Blood pressure and pulse rate were measured in lying, sitting and standing positions and before, during and after isometric and dynamic exercise. Peak expiratory flow was recorded before and during dynamic exercise. All the active treatments were better than placebo in reducing blood pressure and heart rate. Comparing the effects of treatment, labetalol lowered sitting diastolic pressure significantly more than propranolol and standing diastolic pressure than both propranolol and metoprolol. Metoprolol and propranolol were more effective in reducing heart rate. Propranolol significantly reduced peak flow rate compared to labetalol. During the exercise, both isometric and dynamic, the heart rate and the blood pressure, both systolic and diastolic, of the treated patients were lower than those on placebo. There was little difference between the drugs in the influence on blood pressure, but metoprolol and propranolol were significantly more effective than labetalol in lowering the heart rate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00546699
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  • 17
    Digitale Medien
    Digitale Medien
    Reduced peripheral vascular symptoms in elderly patients treated with α-methyldopa — A comparison with propranolol (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 325-329 
    Details
    ISSN: 1432-1041
    Schlagwort(e): alpha-methyldopa ; propranolol ; hypertension ; side effects ; blood pressure control
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A multicentre study of 6–10 weeks duration was performed in 60 ambulant hypertensive patients aged over 60 years to compare the efficacy of methyldopa and propranolol with particular reference to the occurrence of cold extremities and sleep disturbances. Blood pressure was effectively controlled by both drugs being reduced from a mean of 180/108 mmHg to 161/93 with methyldopa and 180/108 to 162/94 with propranolol. More patients treated with methyldopa (74%) achieved the target diastolic blood pressure of 95 mmHg or below compared with those treated with propranolol (58%). Side effects were more frequent in the propranolol group necessitating the withdrawal of four patients from the study. Only one patient on methyldopa was withdrawn. The incidence of cold extremities was significantly greater with propranolol. The occurrence of sleep disturbances was similar in both groups. In this group of elderly patients methyldopa was better tolerated than propranolol.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00548762
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  • 18
    Digitale Medien
    Digitale Medien
    Effect of indapamide on renal plasma flow, glomerular filtration rate and arginine vasopressin in plasma in essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 543-547 
    Details
    ISSN: 1432-1041
    Schlagwort(e): indapamide ; hypertension ; glomerular filtration ; arginine vasopressin ; free water clearance ; blood pressure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Renal plasma flow (RPF), glomerular filtration rate (GFR), arginine vasopressin in plasma (AVP), free water clearance ( $${\text{C}}_{{\text{H}}_{\text{2}} {\text{O}}}$$ ) and blood pressure (BP) were determined in 11 patients with essential hypertension at the end of 3 consecutive periods of observation each of 6 of weeks duration; indapamide 2.5 mg daily was given in period 2 and placebo in periods 1 and 3. RPF and GFR were reduced by 9% and BP by 9%/14% supine and 14%/12% standing during indapamide treatment. Changes in renal haemodynamics were not correlated with those in BP. AVP was not significantly altered by indapamide and was not correlated with BP. Indapamide reduced $${\text{C}}_{{\text{H}}_{\text{2}} {\text{O}}}$$ possibly due to the reduction in GFR. It is concluded that indapamide evidently induces redistribution of the cardiac output, with enhanced muscle blood flow and reduced renal perfussion, and that AVP does not seem to be involved in blood pressure regulation in mild to moderate essential hypertension under basal conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543482
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  • 19
    Digitale Medien
    Digitale Medien
    Is the feeling of cold extremities experienced by hypertensive patients due to their disease or their treatment? (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 47-49 
    Details
    ISSN: 1432-1041
    Schlagwort(e): beta-blockers ; hypertension ; ISA ; CS ; cold extremities
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Patients with essential hypertension were interviewed prior to entering therapeutic studies in general practice. Patients' age, sex and details of antihypertensive therapy (if any) were noted, as were their spontaneously reported symptoms. Complaints of cold extremities were highest in those taking a beta-blocker (4.1%). Those untreated or taking other therapies complained less often. Those patients taking a beta-blocker with ISA complained less often (3.1%) of cold extremities than those taking a beta-blocker without ISA (5.2%).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00553153
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  • 20
    Digitale Medien
    Digitale Medien
    Long acting nifedipine in the treatment of severe hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 13-17 
    Details
    ISSN: 1432-1041
    Schlagwort(e): nifedipine ; hypertension ; blood pressure decrease ; drug combination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The medication of patients receiving hydralazine, captopril and minoxidil was replaced by a new galenical form, long-acting nifedipine. An additional decrease in blood pressure was observed in most of the patients. Renal function was maintained in all of them. Adverse reactions may be reduced by the use of long-acting nifedipine, which would permit a reduction in the dosage of captopril and minoxidil.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395199
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  • 21
    Digitale Medien
    Digitale Medien
    Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 23-27 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; alpha2-adrenoceptors ; blood pressure ; clonidine ; guanfacine ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The time courses of the changes in plasma growth hormone and noradrenaline concentrations in response to 15 min infusions of clonidine 0.2 mgs and guanfacine 2 mgs, were studied in six normal volunteers, in a double-blind, randomised, crossover study. Plasma noradrenaline fell within 15 min of the commencement of drug administration, by 36±14% after clonidine (p〈0.05) and by 32±11% (p〈0.05) after guanfacine. Plasma growth hormone was not significantly elevated until the 30th minute to 12.0±4.7 lU/ml (p〈0.05) after clonidine and 14.7±11.5 lU/ml (p〈0.05) after guanfacine, having been undetectable prior to both drugs. The reduction in plasma noradrenaline by these α2-adrenergic agonists, prior to activation of central adrenoceptors as detected by changes in plasma growth hormone, is evidence for a peripheral component in their sympatholytic effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395201
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  • 22
    Digitale Medien
    Digitale Medien
    Crossover comparison of moxonidine and clonidine in mild to moderate hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 147-152 
    Details
    ISSN: 1432-1041
    Schlagwort(e): moxonidine ; clonidine ; hypertension ; double-blind crossover ; side-effects ; withdrawal
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The antihypertensive effect of moxonidine·HCl·H2O (MOX) was compared with that of clonidine·HCl (CLON) in a randomized double-blind crossover study in 20 hypertensive outpatients (BP range 154–178/96–108 mmHg). After 2 weeks without antihypertensive medication, either MOX 0.2 mg daily or CLON 0.2 mg daily was given and the dose was titrated until the diastolic blood pressure fell below 90 mmHg. The first treatment period was continued for 2 weeks and, after crossover without a wash-out period, it was followed by the second treatment for a further 2 weeks. Within the first 4 days of administration 0.2–0.4 mg of either agent caused a significant decrease in BP (p〈0.001) from a mean of 166/100 mmHg to 149/86 mmHg after CLON (approx. −10/−14%), and 163/99 mmHg to 146/84 mmHg after MOX (approx. −10/−15%). No significant difference in the fall in BP or pulse rate was detected between the two drugs. In the mean daily dose of 0.3 mg both drugs showed the same antihypertensive activity, but on CLON a higher incidence of side effects (p=0.003) was noted, and after discontinuation of therapy a more rapid rise in BP (systolic BP p〈0.01, diastolic BP p〈0.02) was found. 17 patients on CLON complained of side effects, especially tiredness and dry mouth, whilst only 6 patients on MOX were affected (p=0.003).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00544037
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  • 23
    Digitale Medien
    Digitale Medien
    Systemic and cardiac haemodynamic interactions between guanfacine and hydrallazine in hypertensive patients (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 393-396 
    Details
    ISSN: 1432-1041
    Schlagwort(e): guanfacine ; hydrallazine ; hypertension ; sympathetic nervous activity ; plasma renin activity ; cardiac and systemic haemodynamics ; blood pressure ; limb blood flow ; limb vascular resistance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of guanfacine and hydrallazine on cardiovascular haemodynamics and on sympathetic nervous activity has been studied in 16 patients with essential hypertension. Two groups of patients were investigated: in Group A guanfacine brought the blood pressure back to normal (diastolic blood pressure ⩽90 mmHg), and in Group B diastolic blood pressure was 〉 90 mmHg and required the addition of hydrallazine. Guanfacine significantly decreased heart rate, plasma renin activity and urinary excretion of noradrenaline, without altering cardiac contractility. In Group B, guanfacine 2 to 6 mg/day produced a significant decrease in blood pressure from 178.7/112.4 to 164.4/102.9 mmHg and in heart rate from 77.1 to 62.7 beats/min after 4 weeks of treatment. Guanfacine did not significantly alter preejection period, cardiac output or total peripheral resistance. Hydrallazine 50 to 300 mg/day caused a further reduction in blood pressure from 164.4/102.9 to 150.7/90.2 mmHg and an increase in heart rate from 62.7 to 72.1 beats/min. Limb blood flow was increased from 4.55 to 5.93 ml/100 g/min and limb vascular resistance was decreased from 39.55 to 23.6 mmHg 100 g·min/ml. Hydrallazine also caused a slight increase in plasma renin activity and urinary excretion of noradrenaline. It is concluded that guanfacine is a useful agent to block a hydrallazine-induced increase in sympathetic nervous activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00549584
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  • 24
    Digitale Medien
    Digitale Medien
    Piretanide, a potassium stable diuretic, in the treatment of essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 407-414 
    Details
    ISSN: 1432-1041
    Schlagwort(e): piretanide ; hypertension ; triamterene ; double blind comparison ; potassium ; magnesium ; side-effects ; serum electrolytes ; serum parameters
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In a randomized, double blind, parallel group study in out patients with mild to moderate essential hypertension the effects of piretanide on serum electrolytes and on blood pressure were compared with those of triamterene alone and the combination piretanide + triamterene. 136 patients entered the study; 18 patients did not fulfill the inclusion criteria (RRdiast was below 95 mmHg or above 120 mmHg) at the end of the placebo period, 6 dropped out due to side effects, and 1 due to lack of efficacy. Data from 1 patient were not evaluated because the patient did not come regularly for checkups. The results for 110 patients were analyzed. Piretanide 6 mg b.d. and piretanide 6 mg + triamterene 50 mg b.d. produced a significant reduction both in supine and erect blood pressure, which was evident at 2 weeks and which increased over the ensuing 12 week trial period. A mean maximal fall of 16.5% was noted in the piretanide group and 15% in the piretanide + triamterene group. Triamterene alone (50 mg b.d.) also reduced diastolic and systolic blood pressures but the reduction was significantly less (diastolic blood pressure) than in both the piretanide groups, and it showed a more rapid return to pretreatment level during a placebo washout phase at the end of the study. A reduction in standing diastolic blood pressure below 95 mmHg was attained in 84% of patients in the piretanide group, 82% in the piretanide + triamterene group and in only 58% of the triamterene group. There were no significant changes within groups nor differences between the three groups in serum potassium or magnesium. 7 patients were withdrawn from the study because of side-effects due to too marked a clinical action (polyuria, orthostatic disorders and hypotension), one from the piretanide group, and the others in the piretanide + triamterene group. One patient in the triamterene group left the study prematurely due to the lack of effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00549586
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  • 25
    Digitale Medien
    Digitale Medien
    Double-blind comparison of once-daily bopindolol, pindolol and atenolol in essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 529-534 
    Details
    ISSN: 1432-1041
    Schlagwort(e): beta-adrenoceptor blocking agents ; hypertension ; adverse reactions ; atenolol ; bopindolol ; pindolol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The efficacy of once-daily bopindolol, a nonselectiveβ-adrenoceptor blocking agent with partial agonist activity, and of pindolol and atenolol in the treatment of essential hypertension has been compared. 369 patients were investigated in a double-blind parallel-group study. The treatment period was 10 weeks. Blood pressure normalisation (diastolic BP equal to or less than 90 mmHg) was to be achieved by a stepwise increase in the dose of the test drugs, and, if required, by addition of a diuretic. Normalisation of blood pressure was achieved in 71 to 76% of the subjects, with no significant differences between bopindolol, pindolol, and atenolol. Special attention was given to evaluation of side effects by using two methods for registration of all adverse events during the study. A low incidence of drug-induced side effects was observed, with no significant difference between bopindolol, pindolol, and atenolol. There was no evidence of unsuspected adverse reactions due to bopindolol.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00556887
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  • 26
    Digitale Medien
    Digitale Medien
    Comparison of hydrochlorothiazide and atenolol as initial treatment in uncomplicated hypertension (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 157-162 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; hydrochlorothiazide ; atenolol ; side effects ; therapeutic efficacy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary After screening a local population in the northern part of The Netherlands for hypertension, 119 patients with a diastolic pressure (DP) between 95 and 120 mmHg were randomised and treated either with 50 mg hydrochlorothiazide (n=59) or 100 mg atenolol (n=60). After 1 month of treatment 6 patients in the hydrochlorothiazide group and 24 patients in the atenolol group had reached a DP⩽90 mmHg (p〈0.001). 43 of the 50 non-responders to hydrochlorothiazide were switched to atenolol and 30 of the 35 non-responders to atenolol were changed to hydrochlorothiazide. One month after the switch 19 patients in the atenolol group and 2 patients in the hydrochlorothiazide group had reached a DP⩽90 mmHg (p〈0.001). After 6 months of treatment 32 of the 43 atenolol responders and 7 of the 8 hydrochlorothiazide responders were still receiving the same medication, as their DP was still⩽90 mmHg. Non-responders to either medication were given the combination (n=46). 21 patients now became normotensive as did a further 10 after increasing the dose of atenolol to 200 mg. Thus, in all 70 patients had a blood pressure ⩽90 mmHg after treatment for 4 months. Both drugs induced a significant reduction in the total of number of complaints after 1 month of treatment. They did not differ from each other. The reduction was seen both in responders and non-responders and persisted during treatment for 6 months. It is concluded that in terms of short-term efficacy the cardioselective, hydrophilic beta adrenoceptor-blocking drug atenolol is preferable to hydrochlorothiazide in the treatment of uncomplicated hypertension.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00630280
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  • 27
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and hypotensive effect in healthy volunteers of pinacidil, a new potent vasodilator (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 603-608 
    Details
    ISSN: 1432-1041
    Schlagwort(e): pinacidil ; hypertension ; pinacidil pyridine-N-oxide ; urinary excretion ; protein binding ; pharmacokinetics ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Preliminary investigation in 3 healthy volunteers suggested that intravenous pinacidil in a dose of 0.2 mg/kg had a potent but well-tolerated hypotensive action in the supine position. Facial flushing, uncomfortable chest sensation and distressing postural hypotension occurred at serum concentrations above 300 ng/ml. Pinacidil, 0.2 mg/kg, was given intravenously over 4 min to 15 healthy volunteers in the supine position. Maximum fall in mean arterial pressure (MAP) was 15.7±6.0 mmHg. Maximum rise in heart rate was 23.8±6.6 beats/min. Pinacidil serum distribution half-life ( $${\text{T}}_{{\raise0.7ex\hbox{${\text{1}}$} \!\mathord{\left/ {\vphantom {{\text{1}} {{\text{2}}\alpha }}}\right.\kern-\nulldelimiterspace}\!\lower0.7ex\hbox{${{\text{2}}\alpha }$}}}$$ ) was 13.4±8.5 min and elimination half-life ( $${\text{T}}_{{\raise0.7ex\hbox{${\text{1}}$} \!\mathord{\left/ {\vphantom {{\text{1}} {{\text{2}}\beta }}}\right.\kern-\nulldelimiterspace}\!\lower0.7ex\hbox{${{\text{2}}\beta }$}}}$$ ) was 2.13±0.49 h. The apparent volume of distribution (Vdβ) was 90.3±13.21 and total body clearance was 31.1±9.61/h. Pinacidil was approximately 40% bound to plasma protein over the concentration range 40–400 ng/ml. Urinary excretion of unchanged pinacidil accounted for 5.7 ± 1.3% of the administered dose over 24 hours and urinary excretion of the major metabolite, pinacidil pyridine-N-oxide, was 31.6±9.2% of the administered dose. It was concluded that intravenous pinacidil is a potent vasodilator hypotensive compound, with a duration of action between 1.5 and 2 h.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543493
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  • 28
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of endralazine (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 661-661 
    Details
    ISSN: 1432-1041
    Schlagwort(e): endralazine ; hypertension ; elimination half-liefe ; compartment model
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543509
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  • 29
    Digitale Medien
    Digitale Medien
    Long acting nifedipine in the treatment of severe hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 13-17 
    Details
    ISSN: 1432-1041
    Schlagwort(e): nifedipine ; hypertension ; blood pressure decrease ; drug combination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The medication of patients receiving hydralazine, captopril and minoxidil was replaced by a new galenical form, long-acting nifedipine. An additional decrease in blood pressure was observed in most of the patients. Renal function was maintained in all of them. Adverse reactions may be reduced by the use of long-acting nifedipine, which would permit a reduction in the dosage of captopril and minoxidil.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00553147
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  • 30
    Digitale Medien
    Digitale Medien
    Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 23-27 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; alpha2-adrenoceptors ; blood pressure ; clonidine ; guanfacine ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The time courses of the changes in plasma growth hormone and noradrenaline concentrations in response to 15 min infusions of clonidine 0.2 mgs and guanfacine 2 mgs, were studied in six normal volunteers, in a double-blind, randomised, crossover study. Plasma noradrenaline fell within 15 min of the commencement of drug administration, by 36±14% after clonidine (p〈0.05) and by 32±11% (p〈0.05) after guanfacine. Plasma growth hormone was not significantly elevated until the 30th minute to 12.0±4.7 lU/ml (p〈0.05) after clonidine and 14.7±11.5 lU/ml (p〈0.05) after guanfacine, having been undetectable prior to both drugs. The reduction in plasma noradrenaline by these α2-adrenergic agonists, prior to activation of central adrenoceptors as detected by changes in plasma growth hormone, is evidence for a peripheral component in their sympatholytic effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00553149
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  • 31
    Digitale Medien
    Digitale Medien
    Is the feeling of cold extremities experienced by hypertensive patients due to their disease or their treatment? (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 47-49 
    Details
    ISSN: 1432-1041
    Schlagwort(e): beta-blockers ; hypertension ; ISA ; CS ; cold extremities
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Patients with essential hypertension were interviewed prior to entering therapeutic studies in general practice. Patients’ age, sex and details of antihypertensive therapy (if any) were noted, as were their spontaneously reported symptoms. Complaints of cold extremities were highest in those taking a beta-blocker (4.1%). Those untreated or taking other therapies complained less often. Those patients taking a beta-blocker with ISA complained less often (3.1%) of cold extremities than those taking a beta-blocker without ISA (5.2%).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395205
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  • 32
    Digitale Medien
    Digitale Medien
    Pinacidil, a new vasodilator, in the treatment of patients with moderate to severe hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 287-289 
    Details
    ISSN: 1432-1041
    Schlagwort(e): pinacidil ; hypertension ; vasodilator ; patients ; side-effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A new vasodilator drug, pinacidil, N″-cyano-N-4-pyridyl-N′-1, 2,2-trimethylpropylguanidine, was studied in an open trial in 15 patients with moderate to severe hypertension. Four patients received pinacidil monotherapy, and in 11 patients it was used with a diuretic or a beta-blocker. In all but one patient normotension was achieved with a mean daily pinacidil dose of 46.7 mg b.i.d. (range 20–100 mg). Side effects were few and were action-related. There was no evidence of early toxicity. Pinacidil is a promising new antihypertensive vasodilator, which deserves further clinical evaluation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542161
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  • 33
    Digitale Medien
    Digitale Medien
    Phylogenetic influences in microbial hydroxylation of terpenoids (1994)
    Springer
    World journal of microbiology and biotechnology 10 (1994), S. 88-92 
    Details
    ISSN: 1573-0972
    Schlagwort(e): Intelligent screening ; microbial hydroxylation ; multivariate analyses ; taxonomy ; terpenoids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract Forty strains of bacteria and 60 of fungi were screened with globulol, 1,8-cineol and cedrol and the strains compared, on the basis of the resulting products, using multivariate analyses. The taxonomic position of the strains is mirrored in their biotransformation capability. Fungi and bacteria, fungal phyla, and Gram-positive and-negative bacteria could all be distinguished in a discriminant analysis using 12 substrates. Hierarchical clustering yielded five groups of strains with distinct biotransformation activity. Such clustering will allow a more efficient screening than before.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00357570
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  • 34
    Digitale Medien
    Digitale Medien
    Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats (1994)
    Springer
    Molecular and cellular biochemistry 141 (1994), S. 9-13 
    Details
    ISSN: 1573-4919
    Schlagwort(e): hepatocytes ; hypertension ; age ; desaturase ; essential fatty acids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract This study points out the hepatocyte interconversion of the linoleic acid family during hypertension. Hepatocyte Δ6 desaturase activity was higher in 1 month-old spontaneously hypertensive rats than in normotensive controls. A similar tendency was observed in 6 month-old SHR. Δ5 desaturase activity was higher only in 1 month-old spontaneously hypertensive rats as compared to controls. Desaturase activities were particularly high at the age of 6 months. The hepatocyte fatty acid composition showed an impairment of n-6 polyunsaturated fatty acid metabolism in spontaneously hypertensive animals. Changes were greater in the young prehypertensive rats than in adults. A storage of n-3 long chain fatty acids is remarkable in adult hypertensive rats, suggesting an alteration in peroxisomal oxidation. Such modifications may be related to the prostaglandin precursors availability to peripheral tissues such as kidney.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00935585
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  • 35
    Digitale Medien
    Digitale Medien
    A method for examining expression of homologous genes in plant polyploids (1994)
    Springer
    Plant molecular biology 26 (1994), S. 1065-1071 
    Details
    ISSN: 1573-5028
    Schlagwort(e): Brassica ; polyploid ; gene expression ; RT-PCR ; RFLP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract One of the essential issues regarding evolution of polyploid species is how duplicate genes are expressed. Most studies on gene expression in polyploids have been based on isozyme analyses; RNA analysis has not been widely used partially due to difficulties in distinguishing homologous transcripts which usually have the same length and similar or almost identical sequences. In this study, a method combining RT-PCR with RFLP was used to analyze transcripts of homologous genes in natural and synthetic Brassica amphidiploids. Sequences coding for several known genes were selected and used to synthesize gene-specific primers. Total RNAs were used as templates for RT-PCR to amplify homologous transcripts in three diploid parental species, three cultivated amphidiploid species and six synthetic amphidiploids. For each gene, initial PCR products amplified in all species had identical length; however, homologous transcripts in the diploid and amphidiploid species could be distinguished after digesting the PCR products with restriction enzymes. Preliminary results based on three genes indicated that both transcripts from the diploid parents were expressed in the synthetic and natural amphidiploids. This study represents the first application of RT-PCR and RFLP analysis to investigate expression of homologous genes in higher plants. The technique is a sensitive, simple and efficient method for distinguishing homologous transcripts in a mixed RNA population and can be applied to many types of studies on expression of homologous genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00040689
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  • 36
    Digitale Medien
    Digitale Medien
    An RFLP linkage map for loblolly pine based on a three-generation outbred pedigree (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 273-278 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Genetic linkage mapping ; Pinus taeda L.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A genetic linkage map for loblolly pine (Pinus taeda L.) was constructed using segregation data from a three-generation outbred pedigree consisting of four grandparents, two parents, and 95 F2 progeny. The map was based predominantly on restriction fragment length polymorphism (RFLP) loci detected by cDNA probes. Sixty-five cDNA and three genomic DNA probes revealed 90 RFLP loci. Six polymorphic isozyme loci were also scored. One-fourth (24%) of the cDNA probes detected more than 1 segregating locus, an indication that multigene families are common in pines. As many as six alleles were observed at a single segregating locus among grandparents and it was not unusual for the progeny to segregate for three or four alleles per locus. Multipoint linkage analysis placed 73 RFLP and 2 isozyme loci into 20 linkage groups; the remaining 17 RFLP and 4 isozyme loci were unlinked. The mapped RFLP probes provide a new set of codominant markers for genetic analyses in loblolly pine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223631
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  • 37
    Digitale Medien
    Digitale Medien
    Genetic diversity among wild and cultivated populations of Hevea brasiliensis assessed by nuclear RFLP analysis (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 199-207 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Hevea brasiliensis ; RFLP ; Nuclear probes ; Isozyme ; Genetic diversity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Restriction fragment length polymorphism was assessed in wild and cultivated populations of Hevea brasiliensis using random probes from an Hevea nuclear library. One-hundred-and-sixty-four individuals were surveyed, and the results discussed in the light of previous work performed on isozyme variation. Both studies show that germplasm collections have led to an effective enrichment of the genetic resources available for Hevea breeding, and that cultivated clones have conserved a relatively high level of polymorphism, despite their narrow genetic base and their high level of inbreeding. An equivalent level of polymorphism is revealed by random nuclear probes and isozymes. However, the genetic structuring of the diversity appears more striking using RFLP markers. Wild accessions can be divided into three genetic groups according to their geographical origin. The present results are an essential guide to the incorporation of wild material in breeding schemes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225898
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  • 38
    Digitale Medien
    Digitale Medien
    Chromosome assignment of four photosynthesis-related genes and their variability in wheat species (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 383-394 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Photosynthesis-related genes ; Copy numbers ; Chromosome assignments ; RFLP ; Origin of polyploid wheats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Copy numbers of four photosynthesis-related genes, PhyA, Ppc, RbcS and Lhcb1 *1, in wheat genomes were estimated by slot-blot analysis, and these genes were assigned to the chromosome arms of common wheat by Southern hybridization of DNA from an aneuploid series of the cultivar Chinese Spring. The copy number of PhyA was estimated to be one locus per haploid genome, and this gene was assigned to chromosomes 4AL, 4BS and 4DS. The Ppc gene showed a low copy number of small multigenes, and was located on the short arm of homoeologous group 3 chromosomes and the long arm of chromosomes of homoeologous group 7. RbcS consisted of a multigene family, with approximately 100 copies in the common wheat genome, and was located on the short arm of group 2 chromosomes and the long arm of group 5 chromosomes. Lhcb1 *1 also consisted of a multigene family with about 50 copies in common wheat. Only a limited number of restriction fragments (approximately 15%) were used to determine the locations of members of this family on the long arm of group 1 chromosomes owing to the multiplicity of DNA bands. The variability of hybridized bands with the four genes was less in polyploids, but was more in the case of multigene families. RFLP analysis of polyploid wheats and their presumed ancestors was carried out with probes of the oat PhyA gene, the maize Ppc gene, the wheat RbcS gene and the wheat Lhcb1 *1 gene. The RFLP patterns of common wheat most closely resembled those of T. Dicoccum (Emmer wheat), T. urartu (A genome), Ae. speltoides (S genome) and Ae. squarrosa (D genome). Diversification of genes in the wheat complex appear to have occurred mainly at the diploid level. Based on RFLP patterns, B and S genomes were clustered into two major groups. The fragment numbers per genome were reduced in proportion to the increase of ploidy level for all four genes, suggesting that some mechanism(s) might operate to restrict, and so keep to a minimum, the gene numbers in the polyploid genomes. However, the RbcS genes, located on 2BS, were more conserved (double dosage), indicating that the above mechanism(s) does not operate equally on individual genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223649
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  • 39
    Digitale Medien
    Digitale Medien
    RFLP analysis in chrysanthemum. I. Probe and primer development (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 472-478 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; PCR ; Chrysanthemum ; Genetic diversity ; Polyploidy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract In order to study genetic variability at the DNA level in chrysanthemum (Dendranthema grandiflora Tzvelev) PstI and HindIII genomic libraries were constructed. Probes from both libraries were tested for the presence of restriction fragment length polymorphisms (RFLPs). Of the probes from the PstI library 91% appeared to hybridize to low-copy genes, while only 35% of those from the HindIII library appeared to do so. The PstI probes were used in further analyses as 79% of them showed RFLPs, whereas the HindIII low-copy number probes gave only 14% polymorphic patterns. Because of the hexaploid character of chrysanthemum, complex patterns generally consisting of 6–12 fragments were visible on a Southern blot after hybridization. To simplify the genetic analysis, locus-specific polymerase chain reaction (PCR) primers were developed that gave simple polymorphic patterns in a number of cases. The RFLP probes and primers developed will be used in future marker-assisted selection in this polyploid crop.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223663
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  • 40
    Digitale Medien
    Digitale Medien
    Comparative RFLP mapping of Hordeum vulgare and Triticum tauschii (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 865-872 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Comparative mapping ; RFLP ; Barley ; Triticum tauschii ; Genome evolution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Hordeum vulgare (barley) and Triticum tauschii are related, but sexually incompatible, species. This study was conducted to determine the extent of homology between the genomes of barley and T. tauschii using a common set of restriction fragment length polymorphism (RFLP) markers. Results showed that 〉95% of low-copy sequences are shared, but 42% of the conserved sequences showed copy-number differences. Sixty-three loci were mapped in T. tauschii using RFLP markers previously mapped in barley. A comparison of RFLP marker order showed that, in general, barley and T. tauschii have conserved linkage groups, with markers in the same linear orders. However, six of the seven linkage groups of T. tauschii contained markers which mapped to unrelated (i.e., non-homoeologous) barley chromosomes. Additionally, four of the T. tauschii linkage groups contained markers that were switched in order with respect to barley. All the chromosome segments differing between T. tauschii and barley contained markers that were detected by multi-copy probes. The results suggest that the observed differences between the T. tauschii and barley genomes were brought about by duplications or deletions of segments in one or both species. The implications of these findings for genetic mapping, breeding, and plant genome evolution are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00224511
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  • 41
    Digitale Medien
    Digitale Medien
    RFLP-based genetic relationships of Einkorn wheats (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 818-823 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Diploid wheat ; Einkorn ; RFLP ; Taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract To study the relationships between different species of the Einkorn group, 55 different accessions ofTriticum monococcum,T. boeoticum,T. urartu,T. sinskajae,T. thaoudar andT. aegilopoides were analyzed. Fifteen anonymous probes and four clones corresponding to storage protein genes were used for detecting restriction fragment length polymorphisms (RFLPs). The DNA was restricted with the restriction enzymesAluI,HaeIII,RsaI andTaqI. The 25 probe/enzyme combinations employed yielded a total of 488 polymorphic fragments. Statistical analyses were performed using Jaccard's coefficient of similarity and principal coordinate analysis. Different values of similarity within the three main taxa,monococcum,boeoticum andurartu, were obtained; the grouping at the species level was quite well reflected by the RFLP analysis done here. The coincidence between RFLP data and the subspecies classification of theT. monococcum group was only partial. OneT. urartu accession is clearly different from all of the other 54 accessions. The need for an RFLP based revision of the Einkorn taxonomy is evident.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01253991
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  • 42
    Digitale Medien
    Digitale Medien
    Restriction site and length polymorphism of the rDNA unit in the cultivated basidiomycetePleurotus cornucopiae (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 824-830 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Pleurotus cornucopiae ; rDNA unit ; RFLP ; Ribosomal polymorphism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract In the ribosomal DNA unit ofPleurotus cornucopiae, the rDNA coding regions are in the order 5′, 5S-18S-5.8S-25S, 3′, with the 5′ location of the 5S gene differing from its 3′ location found in other basidiomycetes. The most discriminating probe used to study the rDNA polymorphism consisted of a fragment that included the 5S, 18S and part of the 5.8S and 25S genes flanking three intergenic sequences. A high degree of rDNA polymorphism was observed in the sevenP. cornucopiae dikaryons studied. For the first time within a basidiomycete species, the restrictions maps distinguished two types of rDNA units (I and II). In each rDNA type, length variations in the external intergenic sequence IGS 1 located between the 25S and 5S genes allowed characterization of two different rDNA units in type I and four rDNA units in type II. This suggested that theP. cornucopiae rDNA units were derived from two kinds of ancestors (type I and II) by insertion or deletion events (100–700 bp) in the IGS 1. In four dikaryotic strains, two rDNA units of the same type (I or II) differing only by the IGS 1 length, were found in a similar number of copies, and presented a meiotic segregation in homokaryotic progeny. In one progeny, some homokaryotic strains possessed two different rDNA units: one with a high copy number and another with a lower one, showing that two different rDNA units could coexist in a single nucleus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01253992
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  • 43
    Digitale Medien
    Digitale Medien
    Comparison of RFLP and RAPD markers to estimating genetic relationships within and among cruciferous species (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 973-980 
    Details
    ISSN: 1432-2242
    Schlagwort(e): DNA ; RFLP ; RAPD ; Brassica ; Genetic relationships
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Restriction fragment length polymorphism (RFLP) and random amplified polymorphic DNA (RAPD) markers are being used widely for evaluating genetic relationships of crop germplasm. Differences in the properties of these two markers could result in different estimates of genetic relationships among some accessions. Nuclear RFLP markers detected by genomic DNA and cDNA clones and RAPD markers were compared for evaluating genetic relationships among 18 accessions from six cultivated Brassica species and one accession from Raphanus sativus. Based on comparisons of genetic-similarity matrices and cophenetic values, RAPD markers were very similar to RFLP markers for estimating intraspecific genetic relationships; however, the two marker types gave different results for interspecific genetic relationships. The presence of amplified mitochondrial and chloroplast DNA fragments in the RAPD data set did not appear to account for differences in RAPD- and RFLP-based dendrograms. However, hybridization tests of RAPD fragments with similar molecular weights demonstrated that some fragments, scored as identical, were not homologous. In all these cases, the differences occurred at the interspecific level. Our results suggest that RAPD data may be less reliable than RFLP data when estimating genetic relationships of accessions from more than one species.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00220804
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  • 44
    Digitale Medien
    Digitale Medien
    Genetic diversity in European wheat and spelt breeding material based on RFLP data (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 994-1003 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Wheat ; Spelt ; RFLP ; Marker Genetic diversity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Fifty-two winter wheat (Triticum aestivum L.), nine spring wheat, and 20 spelt (Triticum spelta L.) lines representing part of the European breeding germplasm, were assayed for RFLPs (restriction fragment length polymorphisms) with 56 wheat DNA clones and two barley cDNA clones. Objectives of this study were to (1) determine the level of variation for RFLPs in the wheat and spelt breeding lines, (2) characterize the genetic diversity within the European winter wheat germplasm, and (3) evaluate the usefulness of RFLP markers for pedigree analysis and the grouping of wheat and spelt lines of various origins. Seventy-three of the 166 RFLP loci detected with 58 probes and one restriction enzyme were polymorphic for the 81 lines. The percentage of polymorphic loci was greatest for the B genome (58%) and smallest for the D genome (21%). Among the 81 lines, 271 different RFLP bands were detected. RFLP band frequencies of the winter wheat lines differed considerably (≥0.5) from those of the spring wheat lines at five loci, and from those of the spelt lines at 17 loci. Eight cultivars that had a major impact as progenitors on the development of improved winter wheat cultivars accounted for 93% of the observed RFLP bands in winter wheat. Genetic distance (GD) estimates between two lines ranged between 0.01 and 0.21. Mean GD estimates within winter wheat (0.083), within spring wheat (0.108) and within spelt (0.096) were smaller than between spring and winter wheat (0.114), and greatest between winter wheat and spelt (0.132) and spring wheat and spelt (0.148). Principal coordinate analysis performed on GD estimates revealed a clear separation of wheat and spelt germplasm. Novel spelt lines with various proportions of wheat germplasm were positioned between wheat and traditional spelt lines. The spring wheat lines formed a distinct group at the periphery of the distribution of the winter wheat lines. Subgroupings of the winter wheat lines according to the cluster analysis were in good agreement with their origin, and lines with common ancestors were grouped together.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00220807
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  • 45
    Digitale Medien
    Digitale Medien
    Crossover distribution in barley analysed through RFLP linkage data (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 211-216 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Hordeum vulgare ; RFLP ; Genetic map ; Recombination ; Crossover
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The pattern of recombination in barley with regard to (1) the distribution of crossover points among whole gametes, (2) the distribution of crossover points among individual chromosomes and (3) the distribution of crossover points within chromosomes has been analysed using data sets underlying two recently published restriction fragment length polymorphism (RFLP) linkage maps representing male and female meiosis, respectively. The data indicated that the process of recombination had been random with no interference. The two data sets gave similar results, indicating that male and female meiosis in barley do no differ significantly. The possibility of using RFLP data in studies of crossover distribution is stressed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225144
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  • 46
    Digitale Medien
    Digitale Medien
    Characterization of a family of tandemly repeated DNA sequences in Triticeae (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 217-225 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Evolution ; Tandemly repeated DNA sequences ; Phylogenetic relationships ; RFLP ; Poaceae
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The recombinant plasmid dpTa1 has an insert of relic wheat DNA that represents a family of tandemly organized DNA sequences with a monomeric length of approximately 340 bp. This insert was used to investigate the structural organization of this element in the genomes of 58 species within the tribe Triticeae and in 7 species representing other tribes of the Poaceae. The main characteristic of the genomic organization of dpTa1 is a classical ladder-type pattern which is typical for tandemly organized sequences. The dpTa1 sequence is present in all of the genomes of the Triticeae species examined and in 1 species from a closely related tribe (Bromus inermis, Bromeae). DNA from Hordelymus europaeus (Triticeae) did not hybridize under the standard conditions used in this study. Prolonged exposure was necessary to obtain a weak signal. Our data suggest that the dpTa1 family is quite old in evolutionary terms, probably more ancient than the tribe Triticeae. The dpTa1 sequence is more abundant in the D-genome of wheat than in other genomes in Triticeae. DNA from several species also have bands in addition to the tandem repeats. The dpTa1 sequence contains short direct and inverted subrepeats and is homologous to a tandemly repeated DNA sequence from Hordeum chilense.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225145
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  • 47
    Digitale Medien
    Digitale Medien
    Estimation of sampling variance of molecular marker data using the bootstrap procedure (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 259-264 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Bootstrap ; Sampling variance ; Zea mays
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Knowledge of genetic relationships among genotypes is useful in a plant breeding program because it permits the organization of germplasm and provides for more efficient sampling. The genetic distance (GD) among genotypes can be estimated using random restriction fragment length polymorphisms (RFLPs) as molecular markers. Knowledge of the sampling variance associated with RFLP markers is needed to determine how many markers are required for a given level of precision in the estimate of GD. The sampling variance for GD among all pairs of 37 maize (Z. mays L.) inbred lines was estimated from 1202 RFLPs. The 1202 polymorphisms were generated from 251 enzyme-probe combinations (EPC). The sampling variance was used to determine how large a sample of RFLPs was required to provide a given level of precision. The coefficient of variation (CV) associated with GD has a nearly linear relationship between its expected standard deviation and mean. The magnitude of the decrease in the mean CV for GD with increasing numbers of bands was dependent upon the sampling unit; e.g., individual polymorphic bands vs EPC, and the degree of relatedness among the inbreds compared. The rate of reduction in mean CV with increasing sample size was the same regardless of the restriction enzyme used, BamHI, EcoRI or HindIII, when the bootstrap sampling units were individual polymorphic bands. In constrast, although the rate of reduction (slopes) was the same, the intercepts of the mean CVs were different when EPCs were used as the bootstrap sampling unit. This difference was due to the higher number of bands per EPC in BamHI (4.94) compared with EcoRI (4.83) and HindIII (4.63).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225151
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  • 48
    Digitale Medien
    Digitale Medien
    A study of genetic variation and evolution of Phyllostachys (Bambusoideae: Poaceae) using nuclear restriction fragment length polymorphisms (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 265-270 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Bamboo ; Phyllostachys ; RFLP ; Variation ; Evolution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Phylogenetic and taxonomic difficulties are common within the woody bamboos, due to their unique life cycle, which severely limits the availability of floral characters. To addresss some of these problems, 20 species of woody bamboos in the genus Phyllostachys were analyzed using nuclear restriction fragment length polymorphisms (RFLPs). The RFLP data were used to generate genetic distances between all pairs of taxa and to examine the degree of genetic variation within and among bamboo species. The genetic distances were also used to create dendrograms of accessions and species. These trees supported the current division of the genus into two sections and provided some information on the thorny taxonomic problems in this group. We show that RFLPs can be used for species identification and the delineation of species limits.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225152
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  • 49
    Digitale Medien
    Digitale Medien
    Molecular evidence for the hybrid origin of Paulownia Taiwaniana based on RAPD markers and RFLP of chloroplast DNA (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 271-275 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RAPD ; RFLP ; Chloroplast DNA ; Natural hybrid ; Paulownia taiwaniana
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Genomic DNA of Paulownia fortunei, P. kawakamii and P. taiwaniana were amplified with 10-base primers of arbitrary sequences using the polymerase chain reaction (PCR). A total of 351 DNA fragments were amplified from 23 primers and of these 265 fragments (75.5%) were polymorphic. Almost all of the PCR-amplified products of P. taiwaniana were shared by either P. fortunei or P. kawakamii, or both, and the number of polymorphic fragments shared by P. taiwaniana and P. fortunei was about equivalent to those shared by P. taiwaniana and P. kawakamii. Restriction fragments of chloroplast DNA (cpDNA) purified from Paulownia species and from reciprocal crosses between P. fortunei and P. kawakamii were analyzed. Restriction enzyme SalI-digested cpDNA showed an identical pattern in both P. kawakamii and P. taiwaniana. These results further support the hypothesis that P. taiwaniana is the natural hybrid between P. fortunei and P. kawakamii and that the maternal parent of P. taiwaniana is P. kawakamii.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225153
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  • 50
    Digitale Medien
    Digitale Medien
    Molecular markers shared by diverse apomictic Pennisetum species (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 636-642 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Apomixis ; Agamospermy ; Pearl Millet ; Interspecific hybrids ; RFLP ; RAPD
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Two molecular markers, a RAPD (randomly amplified polymorphic DNA) and a RFLP/STS (restriction fragment length polymorphism/sequence-tagged site), previously were found associated with apomictic reproductive behavior in a backcross population produced to transfer apomixis from Pennisetum squamulatum to pearl millet. The occurrence of these molecular markers in a range of 29 accessions of Pennisetum comprising 11 apomictic and 8 sexual species was investigated. Both markers were specific for apomictic species in Pennisetum. The RFLP/STS marker, UGT 197, was found to be associated with all taxa that displayed apomictic reproductive behavior except those in section Brevivalvula. Neither UGT197 nor the cloned RAPD fragment OPC-04600 hybridized with any sexually reproducing representatives of the genus. The cloned C04600 was associated with 3 of the 11 apomictic species, P. ciliare, P. massaicum, and P. squamulatum. UGT197 was more consistently associated with apomictic reproductive behavior than OPC04600 or cloned C04600, thus it could be inferred that UGT197 is more closely linked to the gene(s) for apomixis than the cloned C04600. The successful use of these probes to survey other Pennisetum species indicates that apomixis is a trait that can be followed across species by using molecular means. This technique of surveying species within a genus will be useful in determining the relative importance of newly isolated markers and may facilitate the identification of the apomixis gene(s).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00222459
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  • 51
    Digitale Medien
    Digitale Medien
    RFLP analysis of mitochondrial DNA from cytoplasmic male-sterile lines of pearl millet (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 441-448 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Mitochondrial DNA ; Cytoplasmic male sterility ; Pearl millet
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Mitochondrial DNA (mtDNA) from 13 cytoplasmic male-sterile (cms) lines from diverse sources were characterized by Southern blot hybridization to pearl millet and maize mtDNA probes. Hybridization patterns of mtDNA digested with PstI, BamHI, SmaI or XhoI and probed with 13.6-, 10.9-, 9.7- or 4.7-kb pearl millet mtDNA clones revealed similarities among the cms lines 5141 A and ICMA 1 (classified as the S-A1 type of cytoplasm based on fertility restoration patterns), PMC 30A and ICMA 2. The remaining cms lines formed a distinct group, within which three subgroups were evident. Among the maize mitochondiral gene clones used, the coxI probe revealed two distinct groups of cytoplasms similar to the pearl millet mtDNA clones. The atp9 probe differentiated the cms line 81 A4, derived from P. glaucum subsp. monodii, while the coxII gene probe did not detect any polymorphism among the cms lines studied. MtDNA digested with BamHI, PstI or XhoI and hybridized to the atp6 probe revealed distinct differences among the cms lines. The maize atp6 gene clone identified four distinct cytoplasmic groups and four subgroups within a main group. The mtDNA fragments hybridized to the atp6 gene probe with differing intensities, suggesting the presence of more than one copy of the gene in different stoichiometries. Rearrangements involving the coxI and/or rrn18-rrn5 genes (mapped within the pearl millet clones) probably resulted in the S-A1 type of sterility. Rearrangements involving the atp6 gene (probably resulting in chimeric form) may be responsible for male sterility in other cms lines of pearl millet.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223658
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  • 52
    Digitale Medien
    Digitale Medien
    Use of recombinant substitution lines in the construction of RFLP-based genetic maps of chromosomes 6A and 6B of tetraploid wheat (Triticum turgidum L.) (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 703-712 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Genetic mapping ; Triticum turgidum Recombinant substitution lines (RSLs) ; Mapmaker G-Mendel
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract RFLP-based genetic maps of chromosomes 6A and 6B of Triticum turgidum have been constructed using data obtained by the study of Triticum turgidum var ‘durum’ cv ‘Langdon’-T. t. var ‘dicoccoides’ recombinant substitution lines (RSLs) supplemented with data obtained from F3 families derived from ‘Langdon’ dicoccoides 6A and 6B disomic substitution lines. The average RFLP frequencies detected for the two chromosomes in a test of 45 DNA clones with six restriction enzymes were 56% and 53%, respectively, and a subset of 32 clones gave frequencies of 75% and 72%, respectively. Seventeen loci were mapped in 6A and 18 in 6B. With the possible exception of 5 loci in the centromeric region of 6A, all of the mapped 6A and 6B loci are located in the same arm as are homologous loci in hexaploid wheat, and the linear order of the loci is the same in the two chromosomes, except possibly close to the centromere. Major differences in genetic distances exist between homologous loci located in the proximal regions of the 6AL and 6BL linkage groups, however, the distances being much larger in the former than in the latter. The 6B maps that were constructed using data from both the RSL and the F2 populations and using data from the RSL population alone closely resemble one another, indicating that the 6B RSL population, composed of 85 lines, can be reliably used for genetic mapping. Additional studies must be conducted before the utility of the 6A RSL population, composed of 66 lines, can be adequately assessed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223709
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  • 53
    Digitale Medien
    Digitale Medien
    Sequence-tagged sites (STSs) as standard landmarkers in the rice genome (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 728-734 
    Details
    ISSN: 1432-2242
    Schlagwort(e): STS ; RFLP ; Rice ; Genetic map ; Coding region
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Generating sequence-tagged sites (STSs) is a prerequisite to convert a genetic map to a physical map. With the help of sequence information from these STSs one can also isolate specific genes. For these purposes, we have designed PCR primer sets, of 20 bases each, by reference to sequences of restriction fragment length polymorphism (RFLP) landmarkers consisting of rice genomic clones. These markers were evenly distributed over the 12 chromosomes and were shown to be single copy by Southern-blot analysis. With improved PCR protocols, 63 standard STS landmarkers in the rice genome were generated. Similarity searches of all partial sequences of RFLP landmarkers by the FASTA algorithm showed that 2 of the 63 RFLP landmarkers, G357 and G385, contained part of the ORFs of aspartate aminotransferase and protein kinase, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223712
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  • 54
    Digitale Medien
    Digitale Medien
    Somatic hybrids between Solanum etuberosum and diploid, tuber bearing Solanum clones (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 775-782 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Somatic hybrid ; Solanum etuberosum ; S. tuberosum ; S. berthaultii ; RFLP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Electrofusion was used to obtain somatic hybrids between Solanum etuberosum (2n=2x=24) and two diploid potato lines. These hybridizations were conducted to determine if haploidxwild species hybrids are better fusion partners than conventional S. tuberosumGp. Tuberosum haploids. Restriction fragment length polymerase (RFLP) analyses of the putative somatic hybrids confirmed that each parental genome was present. The somatic hybrids between S. etuberosum and a haploid S. tuberosum clone, US-W730, were stunted and had curled, purple leaves. In contrast, somatic hybrids between S. etuberosum and a haploidxwild species hybrid (US-W 730 haploidx S. berthaultii), were vigorous and generally tuberized under field conditions. These hybrids were designated as E+BT somatic hybrids. Analyses of 23 E+BT somatic hybrids revealed a statistically significant bias towards the retention of S. etuberosum chloroplasts. Stylar incompatibilities were observed when the E+BT somatic hybrids were used as pollen donors in crosses with S. tuberosum cultivars. Reciprocal crosses did not show this incompatibility. The progeny were vigorous and had improved tuber traits when compared to the maternal E+BT parent. RFLP analyses of three sexual progeny lines confirmed the presence of all 12 S. etuberosum chromosomes. In two of these lines, RFLPs that marked each of the 24 chromosome arms of S. etuberosum were present. However, RFLP markers specific for regions on chromosomes 2, 7, and 11 were missing from the third clone. Because other markers for these chromosomes were present in the progeny line, these results indicated the likelihood of pairing and recombination between S. etuberosum and S. tuberosum chromosomes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223718
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  • 55
    Digitale Medien
    Digitale Medien
    Molecular analysis of plants regenerated from embryogenic cultures of wheat (Triticum aestivum L.) (1994)
    Springer
    Theoretical and applied genetics 87 (1994), S. 821-828 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Tissue culture ; Triticum aestivum ; Wheat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Total DNAs of plants regenerated from immature embryo-derived 2-month-old embryogenic calli of wheat (cultivars Florida 302, Chris, Pavon, RH770019) were probed with six maize mitochondrial genes (atpA, atp6, apt9, coxI, coxII, rrn18-rrn5), three hypervariable wheat mitochondrial clones (K′, K3, X2), five random pearl millet mitochondrial clones (4A9, 4D1, 4D12, 4E1, 4E11) and the often-used wheat Nor locus probe (pTA71), in order to assess the molecular changes induced in vitro. In addition, protoplast-derived plants, and 24-month-old embryogenic and non-embryogenic calli and cell suspension cultures of Florida 302 were also analyzed. No variation was revealed by the wheat or millet mitochondrial clones. Qualitative variation was detected in the nonembryogenic suspension culture by three maize mitochondrial genes (coxI, rrn18-rrn5, atp6). A callus-specific 3.8-kb Hind III fragment was detected in all four cultivars after hybridization with the coxI gene. The organization of the Nor locus of the plants regenerated from Florida 302 and Chris was stable when compared to their respective control plants and calli. The Nor locus in regenerants of Pavon and RH, on the other hand, was found to be variable. However, Nor locus variability was not observed in 14 individual seed-derived control plants from either Pavon or RH sources. In Pavon, a 3.6-kb Taq I or a 5.6-kb Bam HI+ Eco RI fragment was lost after regeneration. In one of the RH regenerants, which lost a fragment, an additional fragment was observed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00221134
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  • 56
    Digitale Medien
    Digitale Medien
    QTL analysis of trichome-mediated insect resistance in potato (1994)
    Springer
    Theoretical and applied genetics 87 (1994), S. 973-987 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Potato ; Trichome ; Insect resistance ; RFLP ; QTL
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Genetic mapping of several components of a complex type of insect resistance has been undertaken as a means toward more efficient use of the valuable characteristics of a wild relative of potato. RFLP maps constructed on interspecific diploid progenies of Solanum tuberosum × S. berthaultii were used in conjunction with morphological, biochemical and biological phenotyping to identify quantitative trait loci (QTLs) contributing to trichome-mediated insect resistance. By superimposing QTL data for a wide range of phenotypes including biochemical assays, correlative and direct screens for insect resistance, and adaptation to the target environment on the genetic maps, we have addressed the organization, action and interaction of genes controlling the resistance mechanism. The outcome contributes to an understanding of the association between component traits and between desirable and undesirable features of the donor species generated in an applied breeding program. Research is proceeding toward the development of selectable markers for the introgression and transfer of this resistance among potato gene pools.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225792
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  • 57
    Digitale Medien
    Digitale Medien
    RFLP-based phylogenetic analysis of wide compatibility varieties in Oryza sativa L. (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 65-69 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Oryza sativa L. ; RFLP ; Wide compatibility ; Subspecies differentiation ; Heterosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Twenty-one wide compatibility varieties (WCVs) of rice together with three indica and three japonica testers were assayed with 160 DNA probes that were selected to represent the entire RFLP map at an average interval of 11 cM. On the basis of four enzyme digestion 125 probes detected polymorphisms among the WCVs and subspecies' testers. Among these polymorphic probes there were 68 that could distinguish the indica from the japonica testers. Two dendrograms were constructed on the basis of 398 polymorphic fragments of 125 probes and 139 polymorphic fragments of 68 subspecies' differentiating probes in combination with single enzymes, respectively. The reliability and representativeness of the testers and the levels of DNA variations among WCVs were estimated. The potential of WCVs in the utilization of intersubspecific heterosis is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00222395
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  • 58
    Digitale Medien
    Digitale Medien
    Identification and localization of molecular markers linked to the Lr9 leaf rust resistance gene of wheat (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 110-115 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Leaf rust ; RAPD ; RFLP ; Triticum aestivum ; Triticum spelta
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Near-isogenic lines (NILs) for the leaf rust resistance gene Lr9 were screened for polymorphisms at the molecular level. RAPD (random amplified polymorphic DNA) primers as well as RFLP (restriction fragment length polymorphism) markers were used. Out of 395 RAPD primers tested, three showed polymorphisms between NILs, i.e., an additional band was found in resistant lines. One of these polymorphic bands was cloned and sequenced. Specific primers were synthesized, and after amplification only resistant lines showed an amplified product. Thus, these primers define a sequence-tagged site that is specific for the translocated fragment carrying the Lr9 gene. A cross between a resistant NIL and the spelt (Triticum spelta) variety ‘Oberkulmer’ was made, and F2 plants were analyzed for genetic linkage. All three polymorphisms detected by the PCR (polymerase chain reaction) and one RFLP marker (cMWG684) showed complete linkage to the Lr9 gene in 156 and 133 plants analyzed, respectively. A second RFLP marker (PSR546) was closely linked (8±2.4 cM) to the Lr9 gene and the other four DNA markers. As this marker maps to the distal part of the long arm of chromosome 6B of wheat, Lr9 and the other DNA markers also map to the distal region of 6BL. All three PCR markers detected the Lr9 gene in independently derived breeding lines and varieties, thus proving their general applicability in wheat breeding programs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00222402
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  • 59
    Digitale Medien
    Digitale Medien
    Relationships among Cichorium species and related genera as determined by analysis of mitochondrial RFLPs (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 159-166 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Mitochondrial DNA ; RFLP ; Asteraceae ; Cichorium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Mitochondrial DNA polymorphism was employed to assess cytoplasmic diversity among cytoypes of the genus Cichorium and related genera of the tribe Lactuceae (Asteraceae). Hybridization patterns of total DNA using six restriction enzymes and five heterologous mtDNA probes were examined. From estimates of mtDNA diversity, Cichorium spinosum appeared as an ecotype of C. intybus rather than a separate species. Interspecific mtDNA polymorphism in the genus Cichorium was higher than that observed in Cicerbita Crepis, Lactuca and Tragopogon. Molecular data seemed to indicate that Catananche is very distant from the other genera examined. Intergeneric comparisons allowed the clustering of Cicerbita, Lactuca and Cichorium, genera which belong to different subtribes. However, further molecular investigations on a larger number of genera are needed to clarify the relationships among genera within and between subtribes of the tribe Lactuceae.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225892
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  • 60
    Digitale Medien
    Digitale Medien
    A unique cytoplasmic male sterility (CMS) determinant is present in three Phaseolus species characterized by different mitochondrial genomes (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 314-320 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; mtDNA diversity ; Phaseolus coccineus ; P. polyanthus ; P. vulgaris ; cytoplasmic male sterility
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Previous results have shown that cytoplasmic male sterility (CMS) in lines from Phaseolus coccineus and Phaseolus vulgaris contain the same CMS-specific sequence, raising the question of whether this sequence rearrangement arose before divergence of the two species or afterward with subsequent transfer by introgression. Hybridization patterns of total DNA from eight P. vulgaris lines with cytoplasm from P. coccineus and three P. vulgaris lines were examined in order to analyze the mitochondrial DNA (mtDNA) diversity within each species and to determine differences between CMS lines derived from the two species. Three restriction enzymes and 17 heterologous mtDNA sequences were used. The analysis of the different hybridization patterns revealed a considerable diversity in mtDNA organization particularly within P. coccineus. We obtained distinctive hybridization patterns for the five CMS lines tested. The resulting classification showed that mitochondrial genomes from P. coccineus CMS lines group with those of fertile P. coccineus but not with CMS lines from P. vulgaris. The groupings concur with the taxonomic classification of these lines. The results support the hypothesis of a single ancient origin of the CMS determinant and exclude the transfer of cytoplasm by introgression from P. vulgaris to P. coccineus and P. coccineus ssp polyanthus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223638
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  • 61
    Digitale Medien
    Digitale Medien
    RFLP markers associated with Sr22 and recombination between chromosome 7A of bread wheat and the diploid species Triticum boeoticum (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 1039-1045 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Sr22 ; Triticum aestivum ; T. boeoticum ; Recombination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Analysis of the bread wheat variety Schomburgk, and related lines in its pedigree, identified RFLP markers associated with the segment of chromosome 7A carrying the Sr22 gene derived from the diploid species T. boeoticum. The distribution of the RFLP markers indicated that at least 50% of 7AS and 80% of 7AL in Schomburgk is of T. boeoticum origin. Evaluation of five sets of nearisogenic lines, backcross lines in 20 different genetic backgrounds and an F2 population segregating for Sr22 demonstrated a very low level of recombination between the 7A chromosomes of T. boeoticum and T. aestivum. Several recombinants carrying Sr22 but with a much reduced segment of T. boeoticum were identified and these may prove useful in the breeding of further varieties with Sr22.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00224536
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  • 62
    Digitale Medien
    Digitale Medien
    RFLP diversity in cultivated sorghum in relation to racial differentiation (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 838-844 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Sorghum ; RFLP ; Genetic diversity Cultivated ; Racial differentiation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Careful assessment of the comparative diversity for molecular markers and for potentially-useful morpho-agronomic traits is paramount to the analysis of a genome through the mapping of favorable genes. Sorghum (Sorghum bicolor ssp.bicolor) varieties are traditionally classified into five races on the basis of morphological traits, especially panicle and grain traits. Isozyme diversity has provided a new insight into genetic diversity, and showed a marked geographic structure. We performed RFLP analysis on 94 varieties, chosen to represent the main cross combinations (race × geographic origin), using 35 maize probes that detect polymorphism with at least one of the two restriction enzymesHindIII andXbaI. A total of 50 polymorphic probe-enzyme combinations yielded 158 polymorphic bands. The bicolor race appeared highly variable and included many rare markers. Among the other races multivariate analysis of the data differentiated six clusters corresponding, by decreasing magnitude of divergence, to: the margaritiferum types (a sub-race of race guinea); the guinea forms from western Africa; race caudatum; race durra; race kafir; and the guinea forms from southern Africa.The apparent geographic differentiation was related to the contrasting distribution of these races and to a higher similarity between races localized in southern Africa. The data agree with the current hypotheses on sorghum domestication but reveal associations between neutral markers and traits probably highly subjected to human selection. Whether such associations will be observed with other useful traits, and to what extent they are maintained by genetic linkage, is worth exploring.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01253994
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  • 63
    Digitale Medien
    Digitale Medien
    Molecular cloning and analysis of one member of a polymorphic family of GACA-hybridising DNA repeats in tomato (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 845-851 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Tomato ; Lycopersicon esculentum ; GACA ; Genetic fingerprinting ; RFLP ; PCR
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Simple sequence repeat oligonucleotides were used to probe the tomato genome for elements displaying variability amongst commercial cultivars. The oligonucleotide (GACA)4 was found to be particularly informative on genotype screening blots, hybridising to a highly polymorphic family of elements, and was used to clone one such member from a lambda library. The GACA-hybridisation was localised to a 1.3-kbHinfI fragment within the original 15-kb lambda insert. This 1,349-bp subclone (pT-GACA-2:1.3) was used to probe 27 Californian processing varieties and found to be capable of distinguishing all from each other, thus demonstrating its utility as a genetic fingerprinting probe for cultivar identification. Hybridisation occurred to approximately 10 major high molecular weight (〉 4-kb) bands, most of which segregated independently in F2 populations, as well as a large number of less clearly resolvable smaller fragments. Sequence analysis of the cloned element reveals that it is almost entirely composed of GACA or GATA repeats. These tetranucleotides are organised into distinct repetitive domains, consisting either of tandem arrays of each tetranucleotide or interspersions of GACA and GATA to form dodecanucleotides that are then further repeated. The boundaries between domains contain sufficient departures from the concensus repeat to allow construction of unique polymerase chain reaction (PCR) primers. Amplification from two such contiguous regions identifies length variation in both, thus yielding a genotype screen appropriate for high-throughput applications, such as assessment of purity in F1 hybrid seed lots.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01253995
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  • 64
    Digitale Medien
    Digitale Medien
    The semidwarf gene, sd-1, of rice (Oryza sativa L.). II. Molecular mapping and marker-assisted selection (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 54-59 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Rice ; Semidwarf gene (sd-1) ; RFLP ; Molecular marker ; Marker-assisted selection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract To establish the location of the semidwarf gene, sd-1, the anthocyanin activator (A), purple node (Pn), purple auricle (Pau), and the isozyme locus, EstI-2, in relation to DNA markers on the molecular linkage map of rice, 20 RFLP markers, previously mapped to the central region of chromosome 1 (McCouch et al. 1988), were mapped onto an F2 population derived from the cross Taichung 65 (A,Pn,Pau)/Taichung 65 (sd-1). sd-1 and EstI-2 were determined to be linked most tightly to RFLP markers RG 109 and RG 220, which cosegregated with each other. The distance between these RFLP markers and sd-1 was estimated to be 0.8 cM, based on an observed recombination value of 0.8%. The order of genes and markers in this region of chromosome 1 was determined to be sd-1 — (EstI-2 — RG220 — RG109) — RG381 — A — Pn — Pau. To test the efficacy of selection for sd-1 based on these linked markers, 50-day-old F2 seedlings derived from another cross, Milyang 23/Gihobyeo, were analyzed for marker genotype. At this age, the semidwarf character could not be clearly detected based on phenotype. In addition, plant height was normally distributed in this population, making it difficult to unambiguously identify plants carrying sd-1. Thirteen seedlings homozygous for the sd-1-associated allele at EstI-2, RG220 and RG109, and 13 seedlings homozygous for the Sd-1-associated allele at all three marker loci were selected for further genetic analysis. At 20 days after heading, the culm lengths of these 26 plants were measured and the expected phenotype was confirmed in every case. These 26 plants were then selfed for four generations and F6 lines were again evaluated to determine whether any recombination among the three molecular markers, or between these markers and the sd-1 gene, could be detected. No recombinants were identified, confirming the tight linkage of these loci and the usefulness of genotypic selection for this recessive semidwarf character prior to the time when it can be evaluated based on phenotype.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00226982
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  • 65
    Digitale Medien
    Digitale Medien
    Identification of wheat-Agropyron cristatum monosomic addition lines by RFLP analysis using a set of assigned wheat DNA probes (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 70-75 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Triticum aestivum ; Agropyron cristatum ; Alien addition ; RFLP ; Non-radioactive labelling
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A non-radioactive digoxigenin-labelled DNA method was used successfully to identify RFLP markers in 54 Triticum aestivum cv ‘Chinese Spring’ — Agropyron cristatum (2n=28, genome PPPP) P-genome monosomic addition lines. Southern analysis using a set of 14 DNA probes identifying each homoeologous chromosome arm, combined with two restriction enzymes HindIII and EcoRI, indicated that six A. cristatum chromosomes (1P, 2P, 3P, 4P, 5P and 6P) and five A. cristatum chromosome arms (2PS, 2PL, 5PL, 6PS and 6PL) have been individually added to the wheat genome. The added chromosomes of three lines were Agropyron translocated chromosomes. It was also found that two addition plants possessed an Agropyron-wheat translocation. These results showed that RFLP analysis using the set of assigned wheat probes was a powerful tool in detecting and establishing homoeology of alien A. cristatum chromosomes, or arms, added to wheat, as well as in screening the alien addition material. The creation of the monosomic addition lines should be useful for the transfer of disease-resistance genes from A. cristatum to wheat.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00226985
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  • 66
    Digitale Medien
    Digitale Medien
    Chromosomal localization and molecular-marker tagging of the powdery mildew resistance gene (Lv) in tomato (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 76-79 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Powdery mildew (Leveillula taurica) ; Tomato ; RAPD ; RFLP ; Lv
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We report the tagging of a powdery mildew [Leveillula taurica (Lév.) Arnaud.] resistance gene (Lv) in tomato using RAPD and RFLP markers. DNA from a resistant (cv Laurica) and a susceptible cultivar were screened with 300 random primers that were used to amplify DNA of resistant and susceptible plants. Four primers yielded fragments that were unique to the resistant line and linked to the resistance gene in an F2 population. One of these amplified fragments, OP248, with a molecular weight of 0.7 kb, was subsequently mapped to chromosome 12, 1 cM away from CT134. Using RFLP markers located on chromosome 12, it was shown that approximately one half of chromosome 12 (about 42 cM), in the resistant variety is comprised of foreign DNA, presumably introgressed with the resistance gene from the wild species L. chilense. Further analysis of a backcross population revealed that the Lv gene lies in the 5.5-cM interval between RFLP markers, CT211 and CT219. As a prelude to map-based cloning of the Lv gene, we are currently enriching the density of markers in this region by a combination of RAPD primers and other techniques.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00226986
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  • 67
    Digitale Medien
    Digitale Medien
    Structure and organization of the B genome based on a linkage map in Brassica nigra (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 590-598 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Linkage map ; Brassica nigra ; RFLP ; RAPD
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We constructed a genetic map on Brassica nigra based on a segregating population of 83 F2 individuals. Three different types of molecular markers were used to build the map including isozymes, restriction fragment length polymorphisms (RFLP), and random amplified polymorphic DNA (RAPD). The final map contained 124 markers distributed in 11 linkage groups. The map covered a total distance of 677 cM with the markers distributed within a mean distance of 5.5cM. Of the sequences found in the B. nigra map, 40% were duplicated and organized into three different types of arrangements. They were either scattered throughout the genome, organized in tandem, or organized in blocks of duplicated loci conserved in more than 1 linkage group.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00222453
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  • 68
    Digitale Medien
    Digitale Medien
    Phylogenetic analysis of the genus Hordeum using repetitive DNA sequences (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 801-810 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Hordeum ; Phylogeny ; Repetitive DNA sequences ; RFLP ; In situ hybridization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A set of six cloned barley (Hordeum vulgare) repetitive DNA sequences was used for the analysis of phylogenetic relationships among 31 species (46 taxa) of the genus Hordeum, using molecular hybridization techniques. in situ hybridization experiments showed dispersed organization of the sequences over all chromosomes of H. vulgare and the wild barley species H. bulbosum, H. marinum and H. murinum. Southern blot hybridization revealed different levels of polymorphism among barley species and the RFLP data were used to generate a phylogenetic tree for the genus Hordeum. Our data are in a good agreement with the classification system which suggests the division of the genus into four major groups, containing the genomes I, X, Y, and H. However, our investigation also supports previous molecular studies of barley species where the unique position of H. bulbosum has been pointed out. In our experiments, H. bulbosum generally had hybridization patterns different from those of H. vulgare, although both carry the I genome. Based on our results we present a hypothesis concerning the possible origin and phylogeny of the polyploid barley species H. secalinum, H. depressum and the H. brachyantherum complex.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00224500
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  • 69
    Digitale Medien
    Digitale Medien
    Genetic diversity in cocoa revealed by cDNA probes (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 193-198 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Theobroma cacao ; RFLP ; diversity study seed cDNA
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The variability of the cocoa (Theobroma cacao) nuclear genome was investigated. A total of 203 cocoa clones was surveyed for restriction fragment length polymorphisms (RFLPs) using four restriction endonuclease and 31 seed cDNA probes. A high level of polymorphism has been found. This study points to a structuring of the species that fits with the distinction between the Criollo and Forastero populations. These results combined with previously obtained nuclear rDNA and mtDNA data allow us to propose new hypotheses on the origin and evolution of the different cocoa populations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225897
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  • 70
    Digitale Medien
    Digitale Medien
    Mapping genes for resistance to barley stripe rust (Puccinia striiformis f. sp. hordei) (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 215-219 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Barley stripe rust ; RFLP ; QTL mapping ; Molecular marker-assisted backcrossing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Two genes conferring resistance to the barley stripe rust found in Mexico and South America, previously identified as race 24, were mapped to the M arms of barley chromosomes 7 and 4 in a doubled haploid population using molecular markers and the quantitative trait loci (QTL) mapping approach. The resistance gene on chromosome 7 had a major effect, accounting for 57% of the variation in disease severity. The resistance gene on chromosome 4 had a minor effect, accounting for 10% of the variation in trait expression. Two pairs of restriction fragment length polymorphism markers are being used to introgress the resistance genes to North American spring barley using molecular marker-assisted backcrossing.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225900
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  • 71
    Digitale Medien
    Digitale Medien
    Plastid DNA inheritance and plastome-genome incompatibility in interspecific hybrids of Zantedeschia (Araceae) (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 255-260 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Hybrid variegation ; Plastid DNA ; Interspecific incompatibility ; Zantedeschia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Plastid DNA (ptDNA) probes were used in RFLP analysis to determine ptDNA inheritance in interspecific hybrids in Zantedeschia. Biparental and maternal ptDNA inheritance was found in albino hybrids between the evergreen species Z. aethiopica and several winter-dormant species. From two albino hybrids, different types of ptDNA were detected in shoots derived from different parts of an embryo. This result indicates that plastids were sorted out during embryo development. Only maternal ptDNA was detected in the hybrids of Z. aethiopica × Z. odorata (a summer-dormant species) but paternal, biparental, and maternal ptDNA were found in the hybrids of the reciprocal cross. Z. odorata × Z. aethiopica. By correlating these ptDNA inheritance patterns with the leaf colour (albino, pale-green, and green) of the hybrids, it is suggested that the Z. odorata plastome is incompatible with the Z. aethiopica genome. The Z. aethiopica plastome is partially compatible with the Z. odorata genome but the development of Z. aethiopica plastids appears to be blocked by the presence of the Z. odorata plastids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225906
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  • 72
    Digitale Medien
    Digitale Medien
    Molecular-marker-facilitated investigation of host-plant response to Exserohilum turcicum in maize (Zea mays L.): components of resistance (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 305-313 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Breeding ; Helminthosporium turcicum ; RFLP ; QTLs ; Disease-resistance ; Genetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract RFLPs were used to investigate components of host-plant response to Exserohilum turcicum in 150 unselected F2∶3 lines of a B52/Mo17 maize population. Following inoculation with spore suspensions of the pathogen (race 0), components of disease development were measured and then quantitative trait mapping was performed to identify the location and effects of quantitative trait loci (QTLs) determining host-plant response. Components of interest were the average number of lesions per leaf, the average percent leaf tissue diseased (severity) and the average size of lesions (cm2). Based on a LOD threshold of 2.31 (P〈0.05), the number of lesions appears to be associated with QTLs on chromosomes 1S, 3L, 5S. Severity was associated with analogous regions and, in addition, QTLs on chromosomes 7L and 8L. Most QTLs, for either of these two components, involve additive gene action and partial dominance or overdominance. In contrast, lesion size was associated with QTLs on chromosomes 7L and 5L; recessive gene action may be involved at 7L.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223637
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  • 73
    Digitale Medien
    Digitale Medien
    Epistatic expression of quantitative trait loci (QTL) in soybean [Glycine max (L.) Merr.] determined by QTL association with RFLP alleles (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 486-489 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; QTL ; Epistasis ; Soybean ; Recombinant inbreds
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Quantitative trait values for seed oil and protein content or for maturity were measured in recombinant inbred lines (RIL) of soybean derived from a cross between two soybean cultivars: ‘Minsoy’ PI 27890 and ‘Noir 1’ PI 290136. Seed oil was found to be inversely correlated to protein content. By analyzing DNA from plants with extreme phenotypes, we were able to identify quantitative trait loci (QTL) for these traits as being linked to several restriction fragment length polymorphism (RFLP) loci, including R183 for oil and protein content and R79 for maturity. Cumulative distributions of trait values were graphed for those RIL with ‘Minsoy’ alleles and for those with ‘Noir 1’ alleles. As already suggested by the alleles found associated with extreme phenotypes, the distributions were consistent with an independent and additive expression of the maturity QTL linked to R79. That is, the cumulative distributions for plants with ‘Minsoy’ alleles and for plants with ‘Noir 1’ alleles were similar in shape, but the entire ‘Noir 1’ curve had been shifted to later maturity dates. In contrast, the trait distributions for a locus affecting oil and protein content linked to R183 were not compatible with an additive model. These results suggest that this approach can be used for rapid identification of QTLs with epistatic expression.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223665
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  • 74
    Digitale Medien
    Digitale Medien
    Mitochondrial DMA variation in somatic embryogenic cultures ofLarix (1994)
    Springer
    Theoretical and applied genetics 88 (1994), S. 727-732 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Mitochondria ; Larix ; RFLP ; Somatic embryogenesis ; Somaclonal variation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract outhern hybridization analysis using wheat mitochondrial gene-specific probes indicates that changes in mitochondrial genomic organization and the relative representation of certain genomic regions occur during in vitro somatic embryogenic cell culture ofLarix species. We observed differences in the mitochondrial (mt)DNA hybridization patterns between somatic embryogenic cell cultures and trees grown from seed forLarix leptolepis,L. decidua, and the reciprocal hybrids of these twoLarix species. This is the first study to describe the correlation of molecular changes in a gymnosperm mitochondrial genome with in vitro somatic embryogenic cell culture. Quantitative differences in mtDNA hybridization signals were also observed among a 4-year-old somatic embryogenic cell culture ofLarix ×eurolepis trees regenerated from this culture, and the seed source tree from which the somatic embryogenic cell cultures were initiated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01253977
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  • 75
    Digitale Medien
    Digitale Medien
    CMS in rye: comparative RFLP and transcript analyses of mitochondria from fertile and male-sterile plants (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 1014-1018 
    Details
    ISSN: 1432-2242
    Schlagwort(e): CMS-Secale ; RFLP ; Differential transcription ; cob ; atpA ; atp9
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The mitochondrial (mt) genomes of rye (Secale cereale L.) lines with “normal” and cytoplasmic male sterility (CMS) inducing “Pampa” cytoplasm were compared by detailed restriction fragment length polymorphism (RFLP) and Northern analyses. RFLP analyses using several heterologous mt genes as probes revealed considerable differences in the overall structure of the two mt genomes. With cob and atpA, the data indicate intragenic recombination and/or different copy numbers of these genes in the two cytoplasms. In spite of this heterogeneity at DNA level, the transcriptional patterns of nine out of ten mitochondrial genes analysed are unaffected. The exception is in the “Pampa” cytoplasm which contains an additional cob-homologous transcript. Since this transcript is strongly reduced in the presence of restorer genes, it might causally be correlated to the CMS phenotype.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00224532
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  • 76
    Digitale Medien
    Digitale Medien
    Genetic mapping of the Gy4 and Gy5 glycinin genes in soybean and the analysis of a variant of Gy4 (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 297-304 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Storage protein ; Genome ; RFLP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The predominant storage protein of soybean [Glycine max (L.) Merr.] seed is a globulin called glycinin. Thus far five genes encoding glycinin subunits have been described, and these are denoted by the gene symbols Gy1 to Gy5. The objectives of this study were to map two of these genes, Gy4 and Gy5, and to conduct a genetic analysis of a subunit size-variant from an allele of Gy4. For this purpose a population was formed with an interspecific cross between PI 468916 (G. soja) and A81-356022 (G. max). The two size forms of G4, the subunit from Gy4, segregated codominantly in the mapping population, and were due to a short insertion in the hypervariable region of the mutant protein. The biochemical and molecular characteristics of the two subunits indicate that they are produced from alternate alleles of the same gene. The gene symbols Gy a and Gy b have been assigned to the normal and variant genes, respectively. When genomic DNA from the two parents was probed with a Gy4 cDNA, RFLPs were identified for both Gy4 and Gy5. Using these genetic markers, the Gy4 and Gy5 glycinin genes were mapped in linkage group “O” and “F” on the public soybean genomic map.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225158
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  • 77
    Digitale Medien
    Digitale Medien
    Identification of homoeologous chromosomes in hexaploid oat (A. byzantina cv Kanota) using monosomics and RFLP analysis (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 329-335 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Avena byzantina ; A. sativa ; RFLP ; Homoeology ; C-banding ; Aneuploids ; RFLP mapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The use of RFLP markers, together with a partial set of monosomics available in Avena byzantina cv Kanota, has enabled us to identify putative homoeologous chromosome sets in hexaploid Avena species (2n = 6x = 42, AACCDD). We first identified probes producing distinct three-band patterns on Southern blots that possibly reflect orthologous loci of the three genomes present in the hexaploid. Using monosomic analysis, 51 different restriction fragments that hybridized to 26 probes were localized to 12 different chromosomes for which monosomic stocks were available. These DNA restriction fragments were localized to specific monosomics using image analysis to quantify band intensity relative to other bands in the same lane. From these data, we have tentatively identified two complete homoeologous sets of three chromosomes each and two partial sets of two of the three chromosomes. The results indicate that RFLP dosage analysis is useful in the characterization of homoeologous chromosomes in hexaploid oat where nullisomics for many of the chromosomes are not available. Mention of a trademark or proprietary product does not constitute a guarantee or warranty by the USDA-ARS or the University of Minnesota and does not imply approval over other products that also may be suitable
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225163
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  • 78
    Digitale Medien
    Digitale Medien
    Detection and inheritance of RFLPs in Eucalyptus nitens (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 397-402 
    Details
    ISSN: 1432-2242
    Schlagwort(e): RFLP ; Eucalypts ; Inheritance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The level of polymorphism using genomic and cDNA probes with a number of restriction enzymes and the inheritance of the RFLP loci was investigated in E. nitens. The polymorphism detected with 366 genomic and cDNA probes and three to six restriction enzymes was analysed in three-generation outbred pedigrees. No difference in the level of polymorphism detected with genomic versus cDNA probes was observed. There was a difference in the efficiency of detection of polymorphism with six different restriction enzymes, with three of the enzymes (BglII, DraI and EcoRI) showing substantially more polymorphism than the others. There was no significant correlation between the size of the DNA fragments generated by the enzymes and the detection of polymorphism. Several cases of restriction-site mutations resulting in a polymorphism were observed. The inheritance of 69 loci was analysed in two pedigrees resulting from interpopulational crosses. The majority of the loci segregated according to expected ratios with distortion observed in only 3% of loci. Probes from the cDNA library detected a greater proportion of loci with more than two alleles than did probes from the genomic library. The high polymorphism, large number of alleles, and ease of interpretation of RFLPs in E. nitens means that they will be useful in a range of applications such as genetic linkage maps and paternity analysis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225372
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  • 79
    Digitale Medien
    Digitale Medien
    RFLP studies of genetic relationships among inbred lines of the cultivated sunflower, Helianthus annuus L.: evidence for distinct restorer and maintainer germplasm pools (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 419-425 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Sunflower ; RFLP ; Genetic diversity ; Cytoplasmic male sterility
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract One-hundred-and-eighty-one nuclear DNA probes were used to examine restriction-fragment length polymorphism in inbred lines of the cultivated sunflower (Helianthus annuus L.). The probes were from six libraries: two genomic libraries — one made with PstI and the other with HindIII, and four cDNA libraries — from etiolated plantlets, green leaves, ovaries, petals and anthers. Total DNA from 17 inbred lines representing an overview of the genetic stocks of sunflower, including restorer and maintainer lines of the classical cytoplasmic male sterility, was digested with four different restriction enzymes and probed in 331 probe-enzyme combinations. Of 181 clones analysed, 73 probes were found to be polymorphic. Genetic distances between inbreds were calculated from the resultant proportion of shared bands and submitted to principal component analysis and the UPGMA ‘tree-making’ method. The RFLP analysis allowed a clear differentiation between restorer and maintainer lines of the cytoplasmic male sterility, together with a grouping of some of the genotypes from the same origin. The analysis of the accuracy of distance estimation as a function of the number of probe-enzyme combinations used, indicates that 40–50 combinations ensure a confidence level of near 95%. Considering the inbreds as representatives of the range of cultivated inbreds, estimates of gene diversity, as well as estimates of average gene diversity between and within the sets of restorer and maintainer lines, were calculated. Estimation of gene diversity showed that the available genetic variability in cultivated sunflower, based on allelic frequencies, is lower than that of other plants (H=0.20). Moreover, we show that the proportion of genetic variability due to the difference between maintainer and restorer lines (Dm) is about 2%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225376
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  • 80
    Digitale Medien
    Digitale Medien
    An RFLP-based genetic map of pearl millet (Pennisetum glaucum) (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 481-487 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Pearl millet ; RFLP ; Translocation Genetic maps
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Analysis of a sample of diverse pearl millet genotypes with 200 genomic DNA probes revealed this crop species to be extremely polymorphic. Among these genotypes, 85% of probes detected polymorphism using only two restriction enzymes, with an average pair-wise polymorphism between all of the probe-enzyme combinations of 56%. Two crosses were employed to construct an RFLP-based genetic map. In an intervarietal F2 population, derived from a single F1 plant, 181 loci were placed on a linkage map. The total length of this map, which comprised seven linkage groups, was 303 cM and the average map distance between loci was about 2 cM, although a few intervals in excess of 10 cM were present at the ends of a few linkage groups. Very few clones, including those which hybridized to more than one copy, detected more than one locus in the pearl millet genome. The analysis was complicated initially because 83 of the 181 loci mapped to a single linkage group. Analysis of a second cross identified a probable translocation breakpoint in the middle of this large linkage group.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225384
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  • 81
    Digitale Medien
    Digitale Medien
    Task specialization in a wild bee, Apis florea (Hymenoptera: Apidae), revealed by RFLP banding (1994)
    Springer
    Behavioral ecology and sociobiology 34 (1994), S. 25-30 
    Details
    ISSN: 1432-0762
    Schlagwort(e): Honey bee ; Subfamily ; RFLP ; Task specialization ; Dwarf honey bee ; Thailand ; Multiple mating
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Workers in a wild in situ colony of the dwarf honey bee, Apis florea, were observed undertaking the following behavior: liquid foraging, pollen foraging, guarding, stinging, fanning and wagging abdomen. Bees of each behavioral class were separately collected and frozen. Collections were made over a period of 10 days. Random samples of brood and workers were also collected. DNA was extracted from each bee and “fingerprinted” using a probe of unknown sequence obtained from an A. mellifera genomic library. Patterns of fingerprints (Fig. 1) were dissimilar among behavioral classes (Tables 1 and 2), strongly suggesting a genetic component to division of labor in this species. This result supports similar findings in A. mellifera in a species that is not troubled by many of the experimental difficulties inherent in A. mellifera.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00175455
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  • 82
    Digitale Medien
    Digitale Medien
    Three species of rust fungi (Uredinales) from Okinawa, Japan (1994)
    Springer
    Mycoscience 35 (1994), S. 125-129 
    Details
    ISSN: 1618-2545
    Schlagwort(e): rust fungus ; taxonomy ; Puccinia tarennicola ; Uredinales ; Uredo daphniphylli ; Uredo pipturi
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Three species of rust fungi were reported based on the specimens collected in the islands of the Yaeyama group and Okinawa, Japan.Puccinia tarennicola onTarenna gracilipes andUredo daphniphylli onDaphniphyllum teijsmannii were described as new species.Villebrunea frutescens was added to the host plants ofUredo pipturi.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02318488
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  • 83
    Digitale Medien
    Digitale Medien
    Pollen diameter and fertility in nine species ofPuccinellia (Poaceae) (1994)
    Springer
    Plant systematics and evolution 191 (1994), S. 161-170 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Poaceae ; Puccinellia ; Pollen maximum diameter ; pollen fertility ; taxonomy ; Flora of the Iberian Peninsula
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Diameter and fertility of pollen grains were surveyed in nine species ofPuccinellia Parl. (Poaceae), mainly from the Iberian Peninsula, allowing information about reproductive behaviour and biological characteristics of pollen of these taxa. Maximum diameter was measured with an image processor and fertility was evaluated by staining the grains with Müntzing's mixture. Significant differences in both characters were found between the taxa. In consequence, maximum diameter and fertility proved to have some taxonomic relevance inPuccinellia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984662
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  • 84
    Digitale Medien
    Digitale Medien
    Isoenzyme evidence on the systematics ofHordeum sectionMarina (Poaceae) (1994)
    Springer
    Plant systematics and evolution 191 (1994), S. 213-226 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Poaceae ; Hordeum ; Isoenzymes ; taxonomy ; phylogenetic species ; sibling species
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Morphological differentiation of diploid accessions ofHordeum marinum Huds. s.l. into two varieties, var.marinum and var.fouilladei (Rouy)Nevski is associated with isoenzyme differentiation. The tetraploid form ofH. marinum s.l. exhibited fixed heterozygosity of several heterozymes with one homoeozyme shared with var.fouilladei and the second homoeozyme not found in the two diploids. It also differed from both diploids in the mobility of glucose-6-phosphate dehydrogenase. All three taxa differed in morphs of EST-A. It is concluded that the tetraploid is an allopolyploid with one genome closely related to the diploid var.fouilladei and with the second genome divergent from those of both diploids by genes for unique morphs of eight homoeozymes. On the basis of the isoenzyme data, three phylogenetic sibling species—H. marinum Huds. s.str. (2x),H. geniculatum All. s.str. (= var.fouilladei, 2x), andH. caudatum Jaaska, spec. nova (4x), are proposed within theH. marinum s.l. complex and a key is given.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984666
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  • 85
    Digitale Medien
    Digitale Medien
    Chemical variation in two species of theLecanora subfusca group (Lecanoraceae, lichenizedAscomycotina) (1994)
    Springer
    Plant systematics and evolution 191 (1994), S. 227-236 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Lichenized fungi ; Lecanoraceae ; Lecanora epibryon ; L. subimmersa ; Chemotaxonomy ; biogeography ; taxonomy ; xanthones
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The chemical variation inLecanora epibryon andL. subimmersa, two species of theL. subfusca group, has been examined. In both species the chemical differences are correlated with geographical distribution, but not with morphological differences. As a consequence the chemotypes are recognized at subspecific level. InL. epibryon three chemical races are segregated according to the various chemosyndromes present. Subspeciesepibryon, containing atranorin and triterpenoids, occurs in the northern hemisphere and South America, while the other two subspecies occur only in the southern hemisphere. The subsp.broccha (Nyl.)Lumbsch, comb. nova, contains atranorin, the stictic acid and the 2,5,7-trichloro-3-O-methylnorlichexanthone chemosyndromes, while subsp.xanthophora Lumbsch, subsp. nova, is similar but lacks the stictic acid chemosyndrome. Two chemical races occur in the pantropical speciesL. subimmersa. While subsp.subimmersa contains atranorin and zeorin, subsp.ramboldii Lumbsch & Elix, subsp. nova, contains an additional ten chlorinated xanthones.L. impressa is reduced to synonymy toL. subimmersa.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984667
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  • 86
    Digitale Medien
    Digitale Medien
    The genusIschnea (Asteraceae, Senecioneae) in New Guinea (1994)
    Springer
    Plant systematics and evolution 191 (1994), S. 247-263 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Asteraceae ; Senecioneae ; Blennospermatinae ; Ischnea ; Revision ; taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The endemic New Guinean genusIschnea F. Muell. (Asteraceae, Senecioneae, Blennospermatinae) is revised and four species are recognized. Characters of special interest are tubeless ray florets, male disc florets, and secretory spaces in leaves. A principal component analysis is made on theIschnea elachoglossa F. Muell. complex which shows great variation. One new species,I. capellana Swenson, from the Star Mountains, is described. A key, illustrations, and distribution maps to all species are supplied.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984669
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  • 87
    Digitale Medien
    Digitale Medien
    Phylogenetic relationships of theJuglandaceae (1994)
    Springer
    Plant systematics and evolution 192 (1994), S. 11-29 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Hamamelidae ; Juglandaceae ; rbcL ; phylogeny ; taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A cladistic analysis of molecular data from the chloroplast generbcL was used to examine the taxonomic relationships of the walnut family (Juglandaceae). In addition, chemical and morphological data from a previous study byHufford (1992) were incorporated, expanded, and analyzed independently and in combination with the molecular data. The results of these analyses suggest that theJuglandaceae are more closely related to theFagaceae, Betulaceae, Casuarinaceae, andUrticaceae and their relatives (sensuCronquist 1981) than they are to theAnacardiaceae (sensuThorne 1983). However, sequence data fromrbcL also suggest a relationship between the higherHamamelidae and certain families in theRosidae sensuCronquist 1981 (such asRosaceae andRhamnaceae), an outcome which would add credence to the widely accepted view of the polyphyletic nature of theHamamelidae.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00985904
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  • 88
    Digitale Medien
    Digitale Medien
    Chemistry and micromorphology of compound epicuticular wax crystalloids (Strelitzia type) (1994)
    Springer
    Plant systematics and evolution 193 (1994), S. 115-123 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Angiosperms ; Strelitzia ; Heliconia ; Typha ; Benincasa ; Epicuticular wax ; wax ultrastructure ; wax chemistry ; systematics ; taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Certain non-liliiflorous taxa within the monocotyledons (e.g.,Strelitzia, Heliconia, Typha) are characterized by compound epicuticular wax rodlets (Strelitzia type). Similar rodlets are also encountered on the surface of the dicotyledonous plantBenincasa hispida (Thunb.)Cogn. Chemical analysis of the surface wax from both sources showed that the rodlets are chemically distinct. The rodlets of the monocotyledons consist exclusively of aliphatic wax lipids, mainly wax esters. In contrast, the rodlets ofBenincasa are cheifly composed of triterpenol acetates and triterpenols. Formation of rodlets is therefore interpreted as ultrastructural convergency. It is concluded that taxonomical studies on wax crystalloids can be misleading when interpreted in terms of micromorphology of crystalloids only.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00983545
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  • 89
    Digitale Medien
    Digitale Medien
    The delimitation and taxonomic position of the tropical African generaLeptactina andDictyandra (Rubiaceae) (1984)
    Springer
    Plant systematics and evolution 145 (1984), S. 105-118 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Rubiaceae ; Coffeeae ; Gardenieae ; Pavetteae ; Dictyandra ; Leptactina ; Tarenna ; Pavetta ; Dictyandra congolana sp. nova ; taxonomy ; morphology ; seed-coat ; palynology ; Flora of tropical Africa
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The closely related African generaDictyandra andLeptactina are redelimited. The two genera are distinguished by long tubular corolla-tubes with included anthers (Leptactina) vs. much shorter tubes with exserted anthers (Dictyandra), rather than—as previously thought—presence or absence of multilocellate anthers. The discovery of a new species (Dictyandra congolana from the Congo and W-Zaire) confirms this. It can be concluded, especially from comparative morphological studies of fruits and seeds, thatDictyandra andLeptactina are related toPavetta, Tarenna, Ixora, etc., i.e. the group of genera in theCoffeeae s.l. with terminal inflorescences. It is proposed that the tribePavetteae be revived to accomodate those genera.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984034
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  • 90
    Digitale Medien
    Digitale Medien
    An ultrastructural comparison betweenSpermatozopsis andDunaliella (Chlorophyceae) (1984)
    Springer
    Plant systematics and evolution 146 (1984), S. 31-46 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Chlorophyceae ; Spermatozopsis ; Dunaliella ; D. salina ; Green flagellates ; ultrastructure ; taxonomy ; systematics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The ultrastructure of the type species of the genusDunaliella, D. salina, has been reinvestigated in an attempt to clarify the relationships betweenDunaliella andSpermatozopsis. Dunaliella salina differs in the following ultrastructural characters fromSpermatozopsis (as exemplified byS. similis Preisig etMelkonian): presence of a distinctive surface coat covering the plasmalemma; presence of a prominent pyrenoid (with pairs of thylakoids partially entering the pyrenoid matrix); dictyosomes parabasal; endoplasmic reticulum closely underlying the plasmalemma around most of the cell; contractile vacuoles absent; cell form ovoid to elongated and not spirally twisted; mitochondrial profiles near the flagellar apparatus. Differences in the ultrastructure of the flagellar apparatus: basal body angle more or less fixed; distal connecting fibre cross-striated; system II fibre (rhizoplast) present, associated with mitochondrial profile; system I fibre underlying two-stranded microtubular root; mating structure present. These ultrastructural differences justify distinction between the two taxa at generic level. The problematical status of “freshwater” species ofDunaliella is briefly discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984052
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  • 91
    Digitale Medien
    Digitale Medien
    A light and electron microscopical study of the green flagellateSpermatozopsis similis spec. nova (1984)
    Springer
    Plant systematics and evolution 146 (1984), S. 57-74 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Chlorophyceae ; Spermatozopsis similis ; Green flagellate ; new species ; algal culture ; electron microscopy ; taxonomy ; phylogeny
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The green flagellateSpermatozopsis similis spec. nova has been studied in culture by light and electron microscopy. The flagellate bears two flagella, is naked and has a characteristic crescent and spirally twisted cell shape. The two flagella are of subequal length, each with a prominent hair-point. Each cell contains two contractile vacuoles, a single chloroplast with an anterior eyespot but lacking a pyrenoid, an anteriorly located nucleus, a single dictyosome associated with the posterior end of the nucleus, a single mitochondrion posterior to the nucleus and associated with a small microbody, some conspicuous vacuoles, and a greater number of secondary cytoskeletal microtubules which probably are responsible for maintaining the peculiar shape of this species. SinceS. similis in culture is only biflagellate, it cannot be accommodated within the quadriflagellate, but otherwise very similar speciesS. exsultans. Spermatozopsis similis is compared with other green flagellates and is shown to share common ultrastructural characters withChlamydomonas-type green algae.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984054
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  • 92
    Digitale Medien
    Digitale Medien
    Spiniferomonas septispina andS. enigmata, two new algal species confusing the distinction betweenSpiniferomonas andChrysosphaerella (Chrysophyceae) (1984)
    Springer
    Plant systematics and evolution 148 (1984), S. 103-117 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Algae ; Chrysophyceae ; Spiniferomonas septispina sp. n. ; S. enigmata sp. n. ; Chrysosphaerella ; Morphology ; taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Two new species of non-colonial silica-scaled chrysophytes were discovered in Ontario and were assigned to the genusSpiniferomonas (Chrysophyceae) owing to their solitary cell habit. Scale structure in the two new species is distinctive but includes features common to bothSpiniferomonas andChrysosphaerella. The use of scale structure as the main diagnostic feature to distinguish the two genera is no longer acceptable. A more expedient separation of the two genera based on cell habit (solitary vs. colonial) is proposed and includes the transfer ofChrysospharella salina Birch-Andersen andChrysosphaerella coronacircumspina Wujek & Kristiansen to the genusSpiniferomonas as new combinations. The proposed revision is consistent with existing generic circumscriptions of other ochromonadalean forms with either solitary or colonial cell habit.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984572
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  • 93
    Digitale Medien
    Digitale Medien
    Über einen intrazellulären Parasiten beiCryptomonas (Cryptophyceae), II. (1984)
    Springer
    Plant systematics and evolution 148 (1984), S. 165-167 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Cryptophyceae ; Bodonaceae ; Proteromonas steinii sp. n. ; Cryptomonas spp. div. ; Intracellular parasite ; taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A new intracellular parasite inCryptomonas spp. div. previously known is described asProteromonas steinii spec. nova. The flagellate (infectious) stage isBodo-like, with a distinct kinetoplast. The immobile parasitic stage occurs in the cells of Cryptomonads as a multinucleate trophocyst with a thin mucilage envelope (pseudocyst), while the hypnocyst is uninucleate, walled and bearing two horned projections.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984576
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  • 94
    Digitale Medien
    Digitale Medien
    Gynoecium and perianth inZanthoxylum s.l. (Rutaceae) (1994)
    Springer
    Plant systematics and evolution 189 (1994), S. 165-191 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Angiosperms ; Rutaceae ; Zanthoxylum ; Fagara ; Flower morphology ; perianth ; gynoecium ; acrostylous and anacrostylous-basistylous carpels ; compitum ; taxonomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The question whether the uniseriate perianth ofZanthoxylum L. s. str. is homologous with the calyx or the corolla of taxa included inFagara, or of an independent origin, has been controversial for a long time, but the arguments mostly have remained theoretical. The present investigation of floral structures indicates that there are two different types of uniseriate perianth inZanthoxylum s. str. Therefore, this taxon does not represent a natural group and should be united withFagara asZanthoxylum s.l. The infrageneric taxonomy of this genus is still very ambiguous. It is shown that differences in indumentum, number of sepals and petals (5-4-3) resp. perianth segments (4–9), stamens (3–6), and free carpels (1–5) are of systematic relevance. Particularly important but so far neglected is carpel shape, where an acrostylous and an anacrostylous-basistylous type can be recognized. Stigmata of 2 or more carpels mostly fuse to form a compitum. 4–5-merous flowers with calyx and corolla, and acrostylous carpels are considered as plesiomorphic character states in the genus. On the basis of ± corresponding morphological and phytochemical progressions a working hypothesis about the relationships withinZanthoxylum s.l. is presented in graphical form (Fig. 9).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00939724
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  • 95
    Digitale Medien
    Digitale Medien
    Restriction fragment length polymorphisms distinguish among accessions ofCeratopteris thalictroides andC. richardii (Parkeriaceae) (1994)
    Springer
    Plant systematics and evolution 189 (1994), S. 193-202 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Homosporous ferns ; Parkeriaceae ; Ceratopteris ; C. thalictroides ; C. richardii ; RFLP ; cDNA ; polyploidy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We have used cDNA clones as probes on Southern blots to detect restriction fragment length polymorphisms among sevenCeratopteris thalictroides accessions, threeC. richardii accessions, and one putative interspecific hybrid. We found that the stringency of post-hybridization washes was a critical parameter affecting the quality of our blots; even with homologous cDNA sequences low stringency conditions resulted in a smear of signal, but high stringency washes gave blots with distinct bands. Most probes showed hybridization with four or more genomic fragments. Similarities in the number and size of fragments between and within species indicated that (i)C. richardii shows limited polymorphism among accessions tested, (ii)C. thalictroides is highly polymorphic, and (iii) Hawaiian accessions ofC. thalictroides are divergent relative to their continental cohorts and among themselves. The putative interspecific hybrid did not group closely with either of these species.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00939725
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  • 96
    Digitale Medien
    Digitale Medien
    Allozymic and morphological relationships amongAndrocymbium gramineum, A. europaeum, andA. psammophilum (Colchicaceae) (1994)
    Springer
    Plant systematics and evolution 191 (1994), S. 111-126 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Colchicaceae ; Androcymbium ; Allozymes ; evolution ; taxonomy ; genetic conservation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Levels of allozymic and morphological diversity amongAndrocymbium gramineum, A. europaeum, andA. psammophilum have been assessed using data on 17 allozyme loci and 18 morphological characters. No apparent pattern of geographic or ecological variation was found. Our results also suggest thatA. gramineum andA. europaeum should be considered members of a single species and that the insular speciesA. psammophilum can no longer be thought of as the result of a founder effect fromA. gramineum. Intrapopulational variability was greater than inter-populational variability at both levels studied, which is of strategic interest for the “ex-situ” conservation of these threatened endemic species.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00985346
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  • 97
    Digitale Medien
    Digitale Medien
    Restriction fragment length polymorphisms of the phytohemagglutinin genes inPhaseolus andVigna (Leguminosae) (1994)
    Springer
    Plant systematics and evolution 191 (1994), S. 131-146 
    Details
    ISSN: 1615-6110
    Schlagwort(e): Leguminosae ; Phaseolus ; Vigna ; Lectin genes ; phylogeny ; diversity ; RFLP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Restriction fragment length polymorphisms at the phytohemagglutinin (PHA) locus were determined among 21 genotypes ofPhaseolus vulgaris, P. coccineus, P. acutifolius, P. lunatus, and threeVigna species, using five restriction enzymes and one double digestion, in order to provide molecular evidence for their genetic relatedness. The dissimilarity between genotypes was estimated from binary RFLP data. The dissimilarity was high among species (from 0.75 to 0.95), and of variable extent among genotypes of the same species (0.33–0.89). InP. vulgaris, two different DNA hybridization patterns were found, giving further evidence for two major gene pools in that species. The restriction patterns ofP. vulgaris var.aborigineus, the putative ancestral form ofP. vulgaris, exhibit clear homology toP. vulgaris genotypes. An undefined landrace from Taiwan could be identified as aP. vulgaris genotype. RFLP-based trees for the phytohemagglutinin genes of the species studied were computed with several distance matrix and parsimony methods.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00984660
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  • 98
    Digitale Medien
    Digitale Medien
    Terpsinoe musica Ehrenberg (Bacillariophyceae, centrales), with emphasis on protoplast and cell division (1994)
    Springer
    Aquatic ecology 28 (1994), S. 63-69 
    Details
    ISSN: 1573-5125
    Schlagwort(e): taxonomy ; morphology ; morphogenesis ; Terpsinoe musica
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The morphology of intact cells ofTerpsinoe musica Ehrenberg and aspects of their morphogenesis have not been described before. Cells attach by apical mucus pads to form long bands; the chloroplast consists of numerous small granules. Formation of the new valvae on cell division starts from a central primary silicification site immediately adjacent to the postmitotic nuclei. The septa mentioned in reference works are erroneous interpretations of freely suspended transverse bars, formed at a later moment than the valvae. The absence of septa, and the presence of a labiate process said to be absent in Terpsinoe americana (Bailey) Ralfs, indicate the necessity of a taxonomic revision of the genus. The features said to distinguishTerpsinoe intermedia Grunow are unstable and cannot be regarded to define a separate entity. No evidence has been found for the euryhaline, brackish and even marine ecology mentioned in the literature forTerpsinoe musica, which typically lives in hardwater springs of (sub)tropical regions. The studies were made on populations collected alive at an interval of over half a century, from the same location.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02334246
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  • 99
    Digitale Medien
    Digitale Medien
    Ustilaginales of Commelinaceae (1994)
    Springer
    Mycoscience 35 (1994), S. 353-360 
    Details
    ISSN: 1618-2545
    Schlagwort(e): taxonomy ; Ustilaginales of Commelinaceae ; Ustilago combensis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The seven reported smut fungi on Commelinaceae are revised. Of these, five are recognised and described:Ustilago aneilematis, U. burkillii, U. commelinae, U. nawaschinii andU. tinantiae. Entyloma commelinae is considered to be a doubtful species andU. rwandensis is a synonym ofU. aneilematis. A new species,Ustilago combensis (type onCommelina benghalensis) is proposed. A key to thesee species is presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02268505
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  • 100
    Digitale Medien
    Digitale Medien
    Changes in β-adrenoreceptor density in intact lymphocytes of hypertensive subjects (1984)
    Springer
    Bulletin of experimental biology and medicine 98 (1984), S. 1633-1635 
    Details
    ISSN: 1573-8221
    Schlagwort(e): hypertension ; β-adrenoreceptors ; lymphocytes ; man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00802937
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