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  • Articles  (381)
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  • Occupational Health and Environmental Toxicology  (38)
  • 1980-1984  (381)
  • 1983  (381)
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  • 1
    ISSN: 0197-8462
    Keywords: Macaca monkeys ; electrocardiogram ; blood pressure ; stationary magnetic fields ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Simultaneous measurements were made of the electrocardiogram (ECG) and the intraarterial blood pressure of adult male Macaca monkeys during acute exposures to homogeneous stationary magnetic fields ranging in strength up to 1.5 tesla. An instantaneous, field strength-dependent increase in the ECG signal amplitude at the locus of the T wave was observed in fields greater than 0.1 tesla. The temporal sequence of this signal in the ECG record and its reversibility following termination of the magnetic field exposure are consistent with an earlier suggestion that it arises from a magnetically induced aortic blood flow potential superimposed on the native T-wave signal. No measurable alterations in blood pressure resulted from exposure to fields up to 1.5 tesla. This experimental finding is in agreement with theoretical calculations of the magnetohydrodynamic effect on blood flow in the major arteries of the cardiovascular system.
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  • 2
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    Bioelectromagnetics 4 (1983), S. 21-42 
    ISSN: 0197-8462
    Keywords: biomolecules ; DNA ; microwave absorption ; optical method ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Direct determination of the microwave absorption characteristics of biological molecules in solution by an optical heterodyne technique is described. A visibly transparent sample is irradiated in a spatially nonuniform manner with pulsed microwaves, and the spatial variation in temperature increase measured by detecting the phase chirp impressed on a single-frequency He—Ne laser beam passing through the heated region. Results for several liquids and solutions such as water, methanol, various saline solutions, and solutions of DNA and DNA sodium salt in water are described. Where direct comparison is possible the results agree very well with published values. A significant increase in the absorption of DNA solutions compared with pure water has been observed that is consistent with microwave absorption by the longitudinal mode of the double helix.
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  • 3
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    Bioelectromagnetics 4 (1983) 
    ISSN: 0197-8462
    Keywords: Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
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  • 4
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    Bioelectromagnetics 4 (1983), S. 115-122 
    ISSN: 0197-8462
    Keywords: microwave biological effects ; hyperthermia ; B lymphocytes ; capping ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Normal mouse B lymphocytes were tested for the ability to cap plasma membrane antigenantibody complexes following exposure to 2.45-GHz continuous wave (CW) microwaves at power densities up to 100 mW/cm2 (45 W/kg specific absorption rate), at 37, 41, and 42.5 °C. After a 30-minute treatment, the irradiated cells and the nonirradiated controls were tested for capping by the direct immunofluorescence technique. First, the cells were incubated for nine minutes at 37 °C with fluorescein isothiocyanate-conjugated goat antimouse immunoglobulin. After fixing and washing, the percentage of capped cells was determined under a fluorescence microscope. The results show that for the nonirradiated controls, capping is reduced from 90% at 37 °C, to 52% 41 °C. to less than 5% for cells that were pretreated at 42.5 °C. There was no significant difference between the microwave-treated cells and the controls when both were maintained at the same temperature. In another experiment, there was no significant difference in the percentage of capping between controls and cells that were exposed to microwave radiation during capping, when the temperature in both preparations was kept at 38.5 °C. The results demonstrate that B-lymphocyte capping is sensitive to temperature in the range that is proposed for use in tumor therapy.
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  • 5
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    Bioelectromagnetics 4 (1983), S. 157-165 
    ISSN: 0197-8462
    Keywords: amplitude-modulated RF fields ; hyperthermia ; B lymphocytes ; capping ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: B lymphocytes collected from normal ICR Swiss mouse spleens were exposed in vitro in a Crawford cell to 147-MHz radiofrequency (RF) radiation, amplitude modulated by a 9-, 16-, or 60-Hz sine wave. The power densities ranged between 0.11 and 48 mW/cm2. The irradiated samples and the controls were maintained at 37 °C or 42 °C, with temperature variations less than 0.1 °C. Immediately after a 30-minute exposure, the distribution of antigen-antibody (Ag—Ab) complexes on the cell surface was evaluated at 37 °C by immunofluorescence. Under normal conditions (37 °C, no RF), Ag—Ab complexes are regrouped into a polar cap by an energy-dependent process. Our results demonstrate that the irradiated cells and the nonirradiated controls capped Ag—Ab complexes equally well after exposure at 37 °C. Capping was equally inhibited at 42 °C in both the controls and irradiated cells. No statistically significant differences in capping were observed between the RF-exposed and control samples at any of the modulation frequencies and power densities employed as long as both preparations were maintained at the same temperature.
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  • 6
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    Bioelectromagnetics 4 (1983), S. 167-180 
    ISSN: 0197-8462
    Keywords: air ions ; corona discharge inhalation system ; DC electric fields ; small animal exposure system ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Many previous problems in establishing the nature of biological and behavioral effects of small air ions have been due to poor control over the ion-inhalation microclimate, resulting in nonuniform electrical fields and highly uneven concentrations of small air ions. We have developed a corona discharge air ion-inhalation system for use with animals that incorporates rigorous control over the microclimate and produces highly uniform concentrations of small air ions throughout the exposure area.
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  • 7
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    Bioelectromagnetics 4 (1983), S. 193-204 
    ISSN: 0197-8462
    Keywords: microwaves ; immobilized peroxidase ; chemiluminescence ; luminol ; horseradish peroxidase ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Protein gels formed by crosslinking bovine serum albumin and horseradish peroxidase with glutaraldehyde were used to measure effects on peroxidase activity of 400-MHz (CW) radiofrequency radiation (RFR) at an average specific absorption rate (SAR) of 1.45 W/ kg. The enzyme activity was measured by luminol chemiluminescence recorded on photographic film after hydrogen peroxide activation. Activity was measured during RFR exposure of gels or after exposure of gels polymerized in the RFR field. During exposure, a significant (P 〈 .05) reversible increase occurred in overall mean peroxidase activity of gels activated with 0.88 M H2O2 but not in those activated with 8.8 M H2O2. Gels containing solubilized luminol and formed in the field showed no overall mean increase in peroxidase activity, but did display a highly significant (P 〈 .001) alteration in the distribution of local activities when compared to unexposed gels. These results are apparently due to changes in the rate of diffusion (concentration equilibration) of hydrogen peroxide in the gel.
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  • 8
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    Bioelectromagnetics 4 (1983), S. 249-255 
    ISSN: 0197-8462
    Keywords: radiofrequency radiation ; 27.12 MHz ; hyperthermia ; teratology ; rat ; embryo ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Five groups of pregnant Sprague-Dawley rats were either sham exposed or were irradiated in a 27.12-MHz radiofrequency (RF) field at 55 A/m and 300 V/m on gestation day 9. The absorbed power (approximately 11 W/kg) caused a relatively rapid increase in the rat's colonic temperature. Rats in group I were sham irradiated for 2.5 h at 0 A/m, 0 V/m. In group II RF irradiation was terminated after the rat's colonic temperature reached 41.0 °C. In group III the 41.0- °C temperature was maintained an additional 15 min by varying the field strength. At both temperatures the teratogenic and embryotoxic effects of the RF-induced hyperthermia increased as the exposure duration increased, but the increase was especially noticeable at 42.0 °C. The results indicate that the teratogenic and embryotoxic effects of RF-induced hyperthermia are related to both the temperature of the dam during exposure and the length of time the dam's temperature remains elevated.
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  • 9
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    Bioelectromagnetics 4 (1983), S. 267-279 
    ISSN: 0197-8462
    Keywords: mice ; specific absorption rate ; calorimetry ; TEM chamber ; 200-400 MHz CW ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: A maximum of six live mice, mouse cadavers, prolate spheroids molded from muscle-equivalent tissue, or saline-filled culture flasks, were exposed to continuous wave radiation in a TEM cell at frequencies between 200 and 400 MHz. Whole-body average specific absorption rate (SAR) was determined from power meter measurements of incident, reflected, and transmitted powers. The SARs for both live mice and cadavers were approximately twice that for the prolate spheroid models, and when housed in Plexiglas restraining cages, about 2 1/2 times greater. An error multiplying factor is identified, that quantitatively expresses how SAR data obtained by the three -power-meter method becomes progressively more noisy as the irradiation frequency is lowered or as the TEM cell cross section is increased.
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  • 10
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    Bioelectromagnetics 4 (1983), S. 294-294 
    ISSN: 0197-8462
    Keywords: Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
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  • 11
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    Bioelectromagnetics 4 (1983), S. 295-301 
    ISSN: 0197-8462
    Keywords: fusion reactors ; magnetic fields ; biological effects ; fertilization ; fish ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The sensitivity of trout ova and sperm to 1-T magnetic fields was investigated. It was determined that (1) overall test results combining seven independent Z-statistics demonstrated a significant (α 〈 0.0001) enhancement of fertilization when ova alone were exposed to the magnetic field prior to fertilization; (2) similarly, overall test results combining Z-statistics from eight independent experiments indicated a significant (α 〈 0.0004) enhancement when sperm alone were exposed; and (3) statistical analysis of nine independent experiments confirmed enhanced fertilization (α 〈 0.0001) when both ova and sperm were exposed to the magnetic field prior to fertilization. Although these data indicated that both ova and sperm were sensitive to magnetic fields, simultaneous exposure of both gametes did not have a greater total effect on fertilization rate than the sum of their individual effects.
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  • 12
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    Bioelectromagnetics 4 (1983), S. 341-355 
    ISSN: 0197-8462
    Keywords: microwaves ; microwave hyperthermia ; fever ; febrile convulsions ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: While convulsions associated with fever represent a serious problem in pediatric medicine, conventional animal models of febrile convulsions suffer numerous technical limitations. A microwave-hyperthermia model that eliminates these problems was tested. Microwave energy was used to increase the core temperature of 13- and 17-day-old rats, resulting in convulsions similar to febrile convulsions in human infants. Rats were irradiated for 10 min in circularly polarized waveguides at 918 MHz, CW (average SAR = 9.4 W/kg at 13 days and 18.0 W/kg at 17 days as determined by twin-well calorimetry). Day 17 irradiated rats were less susceptible to convulsions than were day 13 irradiated rats, indicating an age-dependent decline in susceptibility. Contrary to findings of earlier models using infrared or hot-oven heating, convulsions induced with microwave hyperthermia impaired neither brain growth nor subsequent performance during behavioral testing. Simultaneous measurement of brain and rectal temperatures during microwave irradiation revealed differential heating rates that favor thermal homeostasis in brain tissue.
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  • 13
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    Bioelectromagnetics 4 (1983), S. 141-155 
    ISSN: 0197-8462
    Keywords: microwave bioeffects ; hamster macrophages ; immunology ; viricidal macrophages ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Acute exposure of hamsters to microwave energy (2.45 GHz; 25 mW/cm2 for 60 min) resulted in activation of peritoneal macrophages that were significantly more viricidal to vaccinia virus as compared to sham-exposed or normal (minimum-handling) controls. Macrophages from microwave-exposed hamsters became activated as early as 6 h after exposure and remained activated for up to 12 days. The activation of macrophages by microwave exposure paralleled the macrophage activation after vaccinia virus immunization. Activated macrophages from vacciniaimmunized hamsters did not differ in their viricidal activity when the hamsters were microwave or sham-exposed. Exposure for 60 min at 15 mW/cm2 did not activate the macrophages while 40 mW/cm2 exposure was harmful to some hamsters. Average maximum core temperatures in the exposed (25 mW/cm2) and sham groups were 40.5 °C (±0.35 SD) and 38.4 °C (±0.5 SD), respectively. In vitro heating of macrophages to 40.5 °C was not as effective as in vivo microwave exposure in activating macrophages to the viricidal state. Macrophages from normal, shamexposed, and microwave-exposed hamsters were not morphologically different, and they all phagocytosed India ink particles. Moreover, immune macrophage cytotoxicity for virus-infected or noninfected target cells was not suppressed in the microwave-irradiated group (25 mW/cm2, 1 h) as compared to sham-exposed controls, indicating that peritoneal macrophages were not functionally suppressed or injured by microwave hyperthermia.
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  • 14
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    Bioelectromagnetics 4 (1983) 
    ISSN: 0197-8462
    Keywords: Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 15
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    Bioelectromagnetics 4 (1983), S. 215-247 
    ISSN: 0197-8462
    Keywords: electric field ; 60-Hz ; detection ; psychophysics ; rats ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Rats partially deprived of food were trained individually to press a lever in the presence of a vertical, 60-Hz electric field and not to press in its absence. Correct detections that occurred during brief, 3- or 4-s trials occasionally produced a food pellet. The probability of detecting the field was found to increase as field strength increased. The threshold of detection, ie, the field strength required for detections at a probability of 0.5 after correction for errors, was generally between 4 and 10 kV/m. The range of field strengths between almost zero and almost 100% correctness of detection was approximately 8 kV/m. A logistic function provided a good description of the increase in the detection probability with increasing field strength. These performances occurred reliably in 19 rats, some of which were studied for 2 years. Control procedures showed that the behavior required that the rat be in the electric field; the behavior was not controlled by any of several potentially confounding variables.
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  • 16
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    Bioelectromagnetics 4 (1983), S. 257-265 
    ISSN: 0197-8462
    Keywords: shortwave ; diathermy applicators ; heating ; attenuation ; conductivity ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Tissue-substitute models consisting of layers of synthetic, electrically equivalent subcutaneous fat, muscle, and bone shaped in conformation with the normal anatomy are used for rapid determination of distribution of temperature and specific absorption rate throughout the tissues when exposed to electromagnetic radiation. The surfaces of the bisected models are approximated during a short exposure period, then separated and scanned with a thermograph. A method was developed to eliminate the electrical discontinuity at the bisected surfaces while allowing separation and subsequent thermographic scanning. A thin layer of silk screen wetted with propylene glycol saturated with sodium chloride was used at the fat interface and a 0.9% sodium chloride solution was used to wet the screen at the muscle interface to eliminate electrical discontinuity during exposure to 27.12-MHz diathermy. Tests showed that in the presence of an electrical discontinuity the heating pattern was grossly distorted. With the method used, the electrical discontinuity is minimized and the subsequent thermographic scanning reveals that the heating pattern is equivalent to that of an intact model.
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  • 17
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    Bioelectromagnetics 4 (1983) 
    ISSN: 0197-8462
    Keywords: Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 18
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    Bioelectromagnetics 4 (1983), S. 315-326 
    ISSN: 0197-8462
    Keywords: Drosophila ; ELF electromagnetic effects ; oviposition ; development ; viability ; magnetic fields ; DC magnetic fields ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Drosophila flies placed in a habitat with two lateral boxes demonstrated sensitivity to magnetic fields: Oviposition decreased by exposure to pulsated extremely low frequency (ELF) (100)Hz, 1.76 miliTesla (mT) and sinusosidal fields (50 Hz, 1 mT), while there was no initial effect of exposure to a static magnetic field (4.5 mT). Drosophila eggs treated for 48 h with the above described fields showed that (1) mortality of eggs was lower in controls than in eggs exposed to all tested magnetic fields; (2) mortality of larvae increased when a permanent magnet was used; (3) mortality of pupae was highest when a permanent magnet was used; and (4) general adult viability was highest in controls (67%) and diminished progressively when eggs were exposed to pulsated (55%), sinusoidal (45%), and static (35%) magnetic fields.
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  • 19
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    Bioelectromagnetics 4 (1983) 
    ISSN: 0197-8462
    Keywords: Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 20
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    Bioelectromagnetics 4 (1983), S. 11-19 
    ISSN: 0197-8462
    Keywords: electric field ; bone growth ; osteotomy repair ; rats ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Rats were exposed to a 60-Hz electric field at an unperturbed field strength of 100 kV/m to determine its affect on bone growth and fracture repair. Exposure of immature male and female rats for 20 h/day for 30 days did not alter growth rate, cortical bone area, or medullary cavity area of the tibia. In another experiment, midfibular osteotomies were performed and the juvenile rats were exposed at 100 kV/m for 14 days. Evaluation by resistance to deformation and breaking strength indicated that fracture repair was not as advanced in the exposed animals as in the shamexposed animals. In another experiment measurements of resistance to deformation were made in adult rats at 16, 20, and 26 days after osteotmy. Fracture repair was slower in exposed compared to control animals at day 20 and, to a lesser extent, at day 16, but not at day 26.
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  • 21
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    Bioelectromagnetics 4 (1983), S. 55-62 
    ISSN: 0197-8462
    Keywords: 2880-MHz microwaves ; submaxillary salivary gland ; Na+ ; K+ ; Ca2+ ; flame photometry ; hyperthermia ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Na+, K+, and Ca2+ concentrations in the blood serum and submaxillary salivary gland (SSG) were investigated in adult, male rats exposed to 2880-MHz microwaves modulated with 1.5-μs pulses at a pulse repetition rate of 1000 Hz or in a hyperthermal environment. Rats were exposed, one at a time, for 30 min to microwaves producing a specific absorption rate (SAR) of: 4.2, 6.3,6.8,8.4, 10.8, or 12.6 W/kg, or were sham exposed under similar environmental conditions. In a second series, one group of rats was exposed singly for 15, 30, or 60 min to microwaves producing an SAR of 9.5 W/kg and other rats were exposed for similar periods at 40 °C; and 10 rats were sham exposed. Flame photometric analysis indicated that the thresholds of microwave radiation required to induce a change in Na+, K+, and Ca2+ concentrations in the salivary glands are 6.8, 6.8, and 6.3 W/kg, respectively. The directions of Na+, K+, and Ca2+ ion shifts in exposed rats' salivary glands are similar, whether affected by microwaves or hyperthermia. Greater changes in Na+ and K+ concentrations in SSG of rats exposed to microwaves for 15 and 30 min were found than in those exposed at 40 °C. On the other hand, exposure to hyperthermia at 40 °C or to microwaves for 1 h caused Na+ concentration to be increased by 68.7 and 59.5% and K+ concentration to be decreased by 29.6 and 21.7%, respectively.
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  • 22
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    Bioelectromagnetics 4 (1983), S. 63-77 
    ISSN: 0197-8462
    Keywords: microwaves ; exposure chamber ; dosimetry ; rabbit ; body mass ; food consumption ; blood chemistry ; pathology ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Two groups of 16 male New Zealand rabbits were exposed to 2450-MHz continuous wave microwave fields in two experiments of 90 days each. The incident power densities of the first and second experiment were 0.5 and 5 mW/cm2, respectively. During each study, 16 animals were adapted to a miniature anechoic chamber exposure system for at least 2 weeks, then 8 of them were exposed for 7 h daily, 5 days a week for 13 weeks, and the other 8 animals were sham exposed. The rabbits were placed in acrylic cages, and each was exposed from the top in an individual miniature anechoic chamber. Thermography showed a maximum specific absorption rate of 5.5 W/kg in the head and 7 W/kg in the back at 5-mW/cm2 incident power density. After each 7-h exposure session, the animals were returned to their home cages. Food consumption in the exposure chamber and body mass were measured daily. Blood samples were taken before exposure and monthly thereafter for hematological, morphological, chemical, protein electrophoresis, and lymphocyte blast transformation studies. Eyes were examined for cataract formation. Finally, pathological examinations of 28 specimens of organs and tissues of each rabbit were performed. Statistically, there was a significant (P 〈 .01) decrease only of food consumption during the 5-mW/cm2 exposure; other variables were not significantly different between exposed and control groups.
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  • 23
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    Bioelectromagnetics 4 (1983), S. 107-114 
    ISSN: 0197-8462
    Keywords: spermatogenesis ; microwave radiation ; germinal tissue ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Male Sprague-Dawley rats were exposed for 6 h per day for nine days to pulse-modulated microwave radiation (1.3 GHz, at 1-μs pulse width, 600 pulses per second). Exposures were carried out in cylindrical waveguide sections at a mean dose rate of 6.3 mW/g; sham controls were treated similarly and received no irradiation. At time periods corresponding to 0.5, 1.0, 2.0, and 4.0 cycles of the seminiferous epithelium, groups of four shamirradiated and four irradiated rats were killed and the testes removed for analysis. Net mass of the testes, epididymides, and seminal vesicles; daily sperm production (DSP) per testis and per gram of testis; sperm morphology; and the number of epididymal sperm were determined. There were no statistically significant differences between the shamirradiated and irradiated groups with respect to any measured variable. In a group of seven surrogate animals of similar body mass, the dose rate of 6.3 mW/g caused a net change in body temperature (via rectal probe) of 1.5 °C.
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  • 24
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    Bioelectromagnetics 4 (1983), S. 79-90 
    ISSN: 0197-8462
    Keywords: electric fields ; hematology ; serum chemistry ; rats ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Numerous hematologic and serum chemistry variables were examined in rats exposed to unperturbed 60-Hz electric fields at 100 kV/m for 15, 30, 60, or 120 days. Each study was replicated once. Rigorous statistical evaluations of these data did not detect any consistent effect of the electric field for exposures of up to 120 days. It was, however, not unusual in any individual study to detect certain variables that were significantly different between the exposed and shamexposed animals. This emphasizes the need for replicate designs and appropriate statistical analyses when investigating chemical or physical insults that may have minimal influence on biologic function.
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  • 25
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    Bioelectromagnetics 4 (1983), S. 91-101 
    ISSN: 0197-8462
    Keywords: reproductive hazards ; congenital malformations ; high voltage ; epidemiological study ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: A retrospective study on reproductive hazards was performed among 542 employees at Swedish power plants. Questionnaires were answered by 89% of the employees. Data on pregnancies were checked by studying hospital case records. There was a statistically significant, decreased frequency of „normal“ pregnancy outcome, almost exclusively due to an increased frequency of congenital malformations, when the father was a high-voltage switchyard worker. The differences in pregnancy outcome could not be explained by any of the confounding factors analyzed. The total number of children with malformations (26) and the total number of pregnancies in this study, however, were very small.
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  • 26
    Electronic Resource
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    Bioelectromagnetics 4 (1983), S. 293-293 
    ISSN: 0197-8462
    Keywords: Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
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  • 27
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    Bioelectromagnetics 4 (1983), S. 303-314 
    ISSN: 0197-8462
    Keywords: DC electric fields ; exposure systems ; finite difference method (FDM) ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: In most previous 50/60-Hz experiments, subjects were placed in a dielectric cage and the electric field was applied from outside the cage. Although the field outside the cage was kept uniform in space and constant in time, the field inside the cage undergoes undesirable temporal and spatial variations. We have designed an electric-field exposure system that overcomes these problems by having a metal cage constitute a part of the field generating electrodes. The uniformity along the diameter of the cages for mice and cats are more than 84.2% and 74.3%, respectively.
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  • 28
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    Bioelectromagnetics 4 (1983), S. 327-339 
    ISSN: 0197-8462
    Keywords: 60-Hz electric fields ; perinatal exposure ; rat ; visual-evoked response ; central nervous system ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Two independent series of experiments were performed on 114 male Sprague-Dawley derived, albino rat pups, which represented 61 litters in experimental series I and 53 litters in experimental series II. Animals were exposed for 20 h/day from conception to testing (postnatal days 11-20) to a vertical, 65-kV/m, 60-Hz electric field or sham-exposed. Recordings of the visual-evoked response (VER) were obtained using a small silver ball electrode placed epidurally over the visual cortex. Visual stimuli consisted of 10-μS light flashes delivered at 0.2 Hz. Computer-averaged VERs were obtained and power spectral analyses (fast Fourier transform) were performed on the tapered (split cosine-bell window), averaged VERs. The expected age-related changes were clearly evident; however, a detailed analysis of VER component latencies, peak-to-peak amplitude, and power spectra failed to reveal any consistent, statistically significant effect of exposure to 60-Hz electric fields.
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  • 29
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    Bioelectromagnetics 4 (1983), S. 371-381 
    ISSN: 0197-8462
    Keywords: 2,450 MHz ; microwaves ; natural killer cells ; macrophages ; mice ; lymphocytes ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The effect of 2,450-MHz CW microwaves on natural killer (NK) cell activity and lymphocyte responsiveness to mitogen stimulation was studied in mice. Groups of mice were irradiated at power densities of 5, 15, or 30 mW/cm2 (SAR = 3.5, 10.5, and 21 W/kg respectively) for 1.5 h on 2 or 9 consecutive days. NK cell activity was determined using an in vitro 51Cr release cytotoxicity assay and an in vivo tumor-cell clearance assay. No consistent change was observed in the mitogen response of spleen cells from sham compared with irradiated mice. A significant suppression of NK cell activity measured in vitro was observed for mice irradiated at 30 mW/cm2, but not at 15 or 5 mW/cm2. A significant suppression of NK cell activity, as determined using the in vivo tumor clearance assay, was also observed at 30 mW/cm2. NK cell activity, as determined using the in vitro assay, returned to normal within 24 h following the last irradiation. Treatment of mice with hydrocortisone caused suppression of NK cell activity measured in vitro and in vivo. Paradoxically, peritoneal macrophage phagocytosis was enhanced following irradiation at 30 mW/cm2, the power density at which NK activity was suppressed. The possible role that microwave heating plays in producing these effects is discussed.
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  • 30
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    Bioelectromagnetics 4 (1983), S. 383-396 
    ISSN: 0197-8462
    Keywords: hematology ; immunology ; mice ; pulsed microwaves ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Mice were exposed in the far field in an anechoic chamber to 2,880-MHz pulsed microwaves 3 to 7.5 h daily, 5 days/week for 60 to 360 h. Three experiments were performed at average power densities of 5 mW/cm2 and six at 10 mW/cm2, corresponding to averaged specific absorption rates (SARs) of 2.25 and 4.50 mW/g, respectively. Each experiment consisted of eight mice, with a concurrently sham-exposed group of eight. In two of three studies at 5 mW/cm2, there was a significant increase in bone marrow cellularity in the microwave-exposed groups compared to the sham-exposed groups. Significant differences were occasionally seen in erythrocyte, leukocyte, and platelet values from microwaveexposed groups, but were not consistently observed. In one of six groups exposed at 10 mW/cm2, mean bone marrow cellularity was reduced significantly in the microwaveexposed mice; in another group, the lymphocyte count was increased. In only one exposure (10 mW/cm2 for 360 h) was any significant effect noted on serum proteins: a reduction to 5.1 ± 0.3 g/dl in the exposed versus 5.6 ± 0.4 g/dl in the sham-exposed mice. This was due to a decrease in alpha and beta globulins, with no effect on albumin or gamma globulin concentrations. No effect on bone marrow granulocyte/macrophage colony-forming units (CFU) was revealed following exposure of mice to pulsed microwaves at 5 mW/cm2. In one of four exposures at 10 mW/cm2, there was a significant increase in CFU-agar colonies. No significant effects of exposures at 10 mW/cm2 were observed on in vivo and in vitro assays of cell-mediated immune functions. No exposure-related histopathologic lesions were found from examination of several tissues and organs. Results of these series of exposures of mice at SARs of 2.25 and 4.50 mW/g indicated no consistent effects on the hematologic, immunologic, or histopathologic variables examined.
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  • 31
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    Bioelectromagnetics 4 (1983), S. 357-370 
    ISSN: 0197-8462
    Keywords: Helmholtz coils ; electromagnetic fields ; induced currents ; saline media ; biological tissue ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The use of Helmholtz aiding coils to induce small electromagnetic (EM) fields in living tissue for both medical and research purposes has become quite common. While much progress has been made in showing that these induced EM signals can cause a variety of effects in tissues and individual cells, a satisfactory explanation of how the effects occur or how the EM signals couple to the tissue has not yet emerged. To address the latter problem adequately, it becomes necessary to know the spatial distribution of the induced fields inside a given set of boundaries. This paper examines the situation used for much in vitro research where a cylindrical culture dish is filled with a conducting solution and placed between the Helmholtz coils. Two cases are considered. The first assumes that the coils are above and below the culture dish (the planes of the coils are parallel with the top and bottom of the dish); the second assumes that the planes of the coils are parallel with the sides of the dish. A closed form solution is obtained for both cases, and it is shown that the induced EM field distribution is markedly different for the two cases.
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  • 32
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    Bioelectromagnetics 4 (1983), S. 397-400 
    ISSN: 0197-8462
    Keywords: acoustical imaging ; microwave-induced acoustics ; pulsed microwaves ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Pulsed 5.66-GHz microwave energy irradiated a model of a human hand that was positioned above a submerged planar array of 400 hydrophones. Hydrophone response data were analyzed by a computer that graphically reproduced the image.
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  • 33
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    Bioelectromagnetics 4 (1983), S. 103-106 
    ISSN: 0197-8462
    Keywords: Calcium efflux ; insulin ; secretion ; islets of Langerhans ; rabbit ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Rabbit islets of Langerhans were exposed at 37 °C for 18 h to a low-frequency-pulsed magnetic field, generated in paired Helmholtz coils. Exposed islets showed a reduction of 26.1 ± 4.3% in 45Ca2+ content (P 〈 .004). a reduction of 25.1 ± 6.3% in 45Ca2+ efflux (P 〈 .006), and a reduction of 35.0 ± 8.7% (P 〈 .002) in insulin released during glucose stimulation when compared with appropriate controls.
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  • 34
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    Bioelectromagnetics 4 (1983), S. 123-139 
    ISSN: 0197-8462
    Keywords: microwave immunosuppression ; natural killer cells ; hamster immune system ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Hamsters were exposed to repeated or single doses of microwave energy and monitored for changes in core body temperature. circulating leukocyte profiles, serum corticosteroid levels, and natural killer (NK) cell activity in various tissues. NK cytotoxicity was measured in a 15Crrelease assay employing baby hamster kidney (BHK) targets or BHK infected with herpes simplex virus. Repeated exposure of hamsters at 15 mW/cm2 for 60 min/day had no significant effect on natural levels of spleen-cell NK activity against BHK targets. Similarly, repeated exposure at 15 mW/cm2 over a 5-day period had no demonstrable effect on the induction of spleen NK activity by vaccinia virus immunization, that is. comparable levels of NK were induced in untreated and microwave-treated animals. In contrast, treatment of hamsters with a single 60-min microwave exposure at 25 mW/cm2 caused a significant suppression in induced spleen NK activity. A similar but less marked decrease in spleen NK activity was observed in sham-exposed animals. Moreover, the sham effects on NK activity were not predictable and appeared to represent large individual animal variations in the response to stress factors. Depressed spleen NK activity was evident as early as 4 h postmicrowave treatment and returned to normal levels by 8 h. Hamsters exposed at 25 mW/cm2 showed an elevated temperature of 3.0-3.5 °C that returned to normal within 60 min after termination of microwave exposure. These animals also showed a marked lymphopenia and neutrophilia by 1 h posttreatment that returned to normal by 8-10 h. Serum glucocorticosteroids were elevated between 1 and 8 h after microwave treatment. Sham-exposed animals did not demonstrate significant changes in core body temperature. peripheral blood leukocyte (PBL) profile, or glucocorticosteroid levels as compared to minimum-handling controls.
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  • 35
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    Bioelectromagnetics 4 (1983), S. 181-191 
    ISSN: 0197-8462
    Keywords: 60-Hz electric fields ; arousal response ; electric field strength ; mice ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: White-footed mice, Peromyscus leucopus, were exposed to 60-Hz electric fields to study the relationship between field strength and three measures of the transient arousal response previously reported to occur with exposures at 100 kV/m. Five groups of 12 mice each were given a series of four 1-h exposures, separated by an hour, with each group exposed at one of the following field strengths: 75, 50, 35, 25, and 10 kV/m; 8 additional mice were sham-exposed with no voltage applied to the field generator. All mice were experimentally naive before the start of the experiment, and all exposures occurred during the inactive (lights-on) phase of the circadian cycle. The first exposure produced immediate increases in arousal measures, but subsequent exposures had no significant effect on any measure. These arousal responses were defined by significant increases of gross motor activity, carbon dioxide production, and oxygen consumption, and were frequently recorded with field strengths of 50 kV/m or higher. Significant arousal responses rarely occurred with exposures at lower field strengths. Responses of mice exposed at 75 and 50 kV/m were similar to previously described transient arousal responses in mice exposed to 100-kV/m electric fields. Less than half of the mice in each of the field strength groups below 50 kV/m showed arousal responses based on Z (standard) scores, but the arousals of the mice that did respond were similar to those of mice exposed at higher field strengths. Polynomial regression was used to calculate the field strength producing the greatest increases for each of the arousal measures. The results show that the amplitude of the transient arousal response is related to the strength of the electric field, but different measures of arousal may have different relationships to field strength.
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  • 36
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    Bioelectromagnetics 4 (1983), S. 205-214 
    ISSN: 0197-8462
    Keywords: microwaves ; apomorphine ; amphetamine ; morphine ; behavior ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The effects of various psychoactive drugs were studied in rats exposed for 45 min in a circularly polarized, pulsed microwave field (2450 MHz; SAR 0.6 W/kg; 2-μs pulses, 500 pps). Apomorphine-induced hypothermia and stereotypy were enhanced by irradiation. Amphetamine-induced hyperthermia was attenuated while stereotypy was unaffected. Morphine-induced catalepsy and lethality were enhanced by irradiation at certain dosages of the drug. Since these drugs have different modes of action on central neural mechanisms and the effects of microwaves depend on the particular drug studied, these results show the complex nature of the effect of microwave irradiation on brain functions.
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  • 37
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    Bioelectromagnetics 4 (1983), S. 281-292 
    ISSN: 0197-8462
    Keywords: microwaves ; amplitude modulation ; murine allogeneic cytotoxicity ; T lymphocytes ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Significant inhibition of allogeneic cytotoxicity of the target cell MPC-11 by the murine cytotoxic T-lymphocyte line CTLL-1 was observed when the 4-h cytotoxicity assay was conducted in the presence of a 450-MHz field sinusoidally amplitude-modulated at 60 Hz. Exposure of the effector cells to the field prior to adding them to the target cells in the cytolytic assay resulted in a similar inhibition, suggesting a direct interaction of the field with the cytolytic T lymphocyte. The inhibition was preferentially expressed during the early allogeneic recognition phase. Fieldexposed cytolytic cells recovered their full cytolytic capacity in 12.5 h. A differential susceptibility was observed with modulation frequencies from 0 to 100 Hz. Peak suppression occurred at 60 Hz modulation, with progressively smaller effects at 40, 16, and 3 Hz. The unmodulated carrier wave did not affect the cytotoxicity. Effects with 80- and 100-Hz modulation were smaller than at 60 Hz. These results demonstrate an inhibitory but recoverable effect by certain amplitude modulations of weak nonionizing radiation upon the cell-mediated cytolytic immune response.
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  • 38
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    Bioelectromagnetics 4 (1983), S. 43-54 
    ISSN: 0197-8462
    Keywords: microwave radiation ; fertilizing capacity ; turkey sperm ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Turkey sperm were exposed to 2.45-GHz microwave radiation in a temperature-controlled waveguide apparatus. Temperature was maintained at either 25 or 40.5 °C. The sperm were exposed for 30 min at a specific absorption rate (SAR) of 10 or 50 mW/g. Following irradiation, the sperm were used to inseminate virgin turkey hens artificially. During the 9 weeks following the single insemination, the following were assessed: mean number of eggs, percentage of fertile eggs, rate of decrease in egg fertility, percentage of hatched eggs, and percentage of early and late deaths. These data demonstrate that, for the conditions used in these experiments, microwave radiation has no effect on the fertilizing capacity of turkey sperm.
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  • 39
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: Information is represented in long-term memory as a network of associations among concepts. Information is retrieved by spreading activation from concepts in working memory through the network structure. The time required to retrieve information is a function of the level of activation that it achieves. Fanning of multiple paths from a node dissipates the activation the node sends down any path and increases retrieval time. Fan effects are reduced as subjects overlearn the material or when they can change their task from a recognition judgment to a consistency judgment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J R -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):25-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828877" target="_blank"〉PubMed〈/a〉
    Keywords: Face ; Humans ; *Memory ; Mental Recall ; Pattern Recognition, Visual
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-13
    Description: The existence of low-level filtering of sensory input is a point of debate among cognitive theorists. This present study suggests that filtering by modality exists at levels low enough to modulate the brainstem blink reflex and that it is evident as early as the 16th week of life. During foreground listening or looking conditions, blinks elicited by acoustic or visual probes were larger when probe and foreground modality matched than when they mismatched. "Interesting" foregrounds, by comparison with "dull" ones, intensified the modality-selective effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anthony, B J -- Graham, F K -- HDO1490/HD/NICHD NIH HHS/ -- K3-MH21762/MH/NIMH NIH HHS/ -- MHO1798/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):742-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836312" target="_blank"〉PubMed〈/a〉
    Keywords: Attention/*physiology ; Blinking ; Child Development ; Electromyography ; Hearing/physiology ; Heart Rate ; Humans ; Infant ; *Psychology, Child ; Vision, Ocular/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: The human parasite Trypanosoma brucei gambiense grew continuously at 37 degrees C in primary cultures of murine bone marrow. Cultured parasites remained virulent for mice. Rapid parasite growth coincided with the appearance of adherent adipocyte-epitheloid cell aggregates that also promoted hematopoiesis. This culture system should permit studies of host cell control of trypanosome proliferation, pathogenic effects of trypanosomes on blood cell development, and the relative trypanocidal and marrow suppressive activities of drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balber, A E -- CA 14049/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836284" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow ; Cells, Cultured ; Culture Media ; Humans ; Mice ; Mice, Inbred BALB C ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei gambiense/*growth & development ; Trypanosomiasis, African/parasitology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: Blink-startle responses to vibroacoustic stimulation were monitored ultrasonically in human fetuses of known gestational age. Responses were first elicited between 24 and 25 weeks of gestational age and were present consistently after 28 weeks. Defining the developmental sequence for audition provides a foundation for diagnosing deafness and recognizing aberrant responses antenatally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnholz, J C -- Benacerraf, B R -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):516-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623091" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Ear/*embryology ; Female ; Fetus/*physiology ; Gestational Age ; *Hearing ; Humans ; Pregnancy ; Ultrasonography ; Vibration
    Print ISSN: 0036-8075
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  • 43
    Publication Date: 1983-04-15
    Description: Spirochetes believed to be the cause of Lyme disease were isolated from white-footed mice and white-tailed deer, the preferred natural hosts of Ixodes dammini, the tick vector. Evidence suggests that deer act as a reservoir of the disease and provide an overwintering mechanism for both spirochetes and adult ticks. Some tick larvae may acquire the spirochete by transovarial passage and the nymphal stage may transmit the disease to humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosler, E M -- Coleman, J L -- Benach, J L -- Massey, D A -- Hanrahan, J P -- Burgdorfer, W -- Barbour, A G -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836274" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachnid Vectors/microbiology ; Arthritis, Infectious/microbiology/transmission ; Deer/microbiology/parasitology ; Disease Vectors ; Female ; Humans ; Male ; Peromyscus/microbiology/parasitology ; Spirochaetales/*growth & development ; Ticks/*microbiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 44
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 9;222(4628):1072-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648522" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Costs and Cost Analysis ; Humans ; Neoplasms/*prevention & control
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Oct 14;222(4620):118-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623060" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Multiple Myeloma/*etiology ; Neoplasms, Radiation-Induced/*etiology ; Nuclear Warfare ; *Veterans Disability Claims
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉HD-12572/HD/NICHD NIH HHS/ -- MH-00318/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):74-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623059" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Child, Preschool ; *Eye Movements ; Humans ; Research Design
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Apr 8;220(4593):142, 144, 146.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828887" target="_blank"〉PubMed〈/a〉
    Keywords: Dental Caries/*prevention & control ; *Fluoridation ; Humans ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-23
    Description: The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ames, B N -- ES01896/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1256-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6351251" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; *Carcinogens/antagonists & inhibitors ; Cocarcinogenesis ; Diet/*adverse effects ; Dietary Fats/adverse effects ; Free Radicals ; Hot Temperature ; Humans ; Lipid Peroxides/adverse effects ; Mutagens ; Oxygen/*toxicity ; Plants, Edible ; Smoking
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  • 49
    Publication Date: 1983-04-29
    Description: Suitably brief pulses of selectively absorbed optical radiation can cause selective damage to pigmented structures, cells, and organelles in vivo. Precise aiming is unnecessary in this unique form of radiation injury because inherent optical and thermal properties provide target selectivity. A simple, predictive model is presented. Selective damage to cutaneous microvessels and to melanosomes within melanocytes is shown after 577-nanometer (3 x 10(-7) second) and 351-nanometer (2 x 10(-8) second) pulses, respectively. Hemodynamic, histological, and ultrastructural responses are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, R R -- Parrish, J A -- R01025395/PHS HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):524-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836297" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Hot Temperature ; Humans ; *Laser Therapy ; Melanins/metabolism ; Melanocytes/ultrastructure ; Microcirculation/surgery ; Microscopy, Electron ; Microsurgery/*methods
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-27
    Description: Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antoniades, H N -- Hunkapiller, M W -- CA30101/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):963-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844921" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Electrophoresis, Polyacrylamide Gel ; Growth Substances/genetics/*metabolism ; Humans ; Molecular Weight ; Peptides/genetics/*metabolism ; Platelet-Derived Growth Factor
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  • 51
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The exposure of the population of Utah to external gamma-radiation from the fallout from nuclear weapons tests carried out between 1951 and 1958 at the Nevada Test Site has been reconstructed from recent measurements of residual cesium-137 and plutonium in soil. Although the highest exposures were found in the extreme southwest part of Utah, as expected, the residents of the populous northern valleys around Provo, Salt Lake City, and Ogden received a higher mean dose and a significantly greater population dose (person-rads) than did the residents of most counties closer to the test site. However, population doses from external exposure throughout Utah were far too low to result in any statistically observable health effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beck, H L -- Krey, P W -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828876" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Exposure ; Gamma Rays ; Humans ; Leukemia/etiology ; Nevada ; *Nuclear Warfare ; *Radiation ; Radiation Dosage ; Utah
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  • 52
    Publication Date: 1983-06-17
    Description: Animals with a history of receiving daily injections of +-amphetamine in a specific environment showed a placebo effect (enhanced activity) when injected with saline and placed there; control animals with similar but dissociated drug histories and experience with the test chamber failed to show the effect. The dopamine receptor blocker pimozide antagonized the establishment of conditioning. However, the same dose of pimozide, when given to previously conditioned animals on the placebo test day, failed to antagonize the expression of conditioned activity. Thus, during conditioning dopaminergic neurons mediated a change that subsequently influenced behavior even when dopaminergic systems were blocked. Although schizophrenia may be related to hyperfunctioning of dopamine, neuroleptic drugs, which block dopamine receptors on their first administration, do not have therapeutic effects for a number of days. The results of the pimozide experiments may resolve this paradox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beninger, R J -- Hahn, B L -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology)/*drug effects/physiology ; Dextroamphetamine/antagonists & inhibitors/*pharmacology ; Humans ; Male ; Pimozide/*pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/physiology ; Reinforcement (Psychology) ; Schizophrenia/physiopathology
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  • 53
    Publication Date: 1983-04-29
    Description: Selective pharmacological inhibition of thromboxane A2 synthesis did not prevent arachidonate-induced aggregation of human platelets in vitro. Prevention was instead achieved by a combination of thromboxane A2 inhibitors with low concentrations of aspirin. The latter partially reduced the proaggregatory cyclooxygenase products that accumulated when thromboxane A2 synthesis was blocked. The aspirin concentrations did not affect per se either platelet aggregation or prostacyclin synthesis in cultured human endothelial cells. The combination of thromboxane synthetase inhibitors with low doses of aspirin may offer greater antithrombotic potential than either drug alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bertele, V -- Falanga, A -- Tomasiak, M -- Dejana, E -- Cerletti, C -- de Gaetano, G -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):517-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682245" target="_blank"〉PubMed〈/a〉
    Keywords: Aspirin/*pharmacology ; Blood Platelets/*drug effects/enzymology ; Dose-Response Relationship, Drug ; Drug Interactions ; Humans ; Imidazoles/pharmacology ; Methacrylates/pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Platelet Aggregation/drug effects ; Thromboxane-A Synthase/*antagonists & inhibitors
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: Monkeys in which nerves innervating the flexor muscles of the forearm and hand (the ulnar or the median nerve) had been surgically cross-united with the nerve innervating the extensor muscles (the radial nerve), and vice versa, showed excellent (ulnar-radial crosses) to moderate (median-radial crosses) control of movement performance after regeneration. Antagonistic movement responses were seen occasionally, but these were corrected almost immediately. Stimulation of the crossed nerves showed that they had innervated the antagonistic muscle groups. The results reveal the capacity of the primate central nervous system to adapt to gross disturbances imposed on the execution of movements by changes in peripheral innervation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinkman, C -- Porter, R -- Norman, J -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):438-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836289" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fingers/physiology ; Forearm/*innervation/physiology ; Hand/innervation/physiology ; Humans ; Macaca fascicularis ; Macaca nemestrina ; Median Nerve/physiology ; *Movement ; *Neuronal Plasticity ; Radial Nerve/physiology ; Thumb/physiology ; Ulnar Nerve/physiology
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  • 55
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capron, Alexander M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644013" target="_blank"〉PubMed〈/a〉
    Keywords: Coercion ; Humans ; Mandatory Programs ; *Public Policy ; *Tissue Donors ; *Tissue and Organ Procurement ; United States ; Voluntary Programs
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  • 56
    Publication Date: 1983-01-28
    Description: The defensive siphon and gill withdrawal reflex of Aplysia is a simple reflex mediated by a well-defined neural circuit. This reflex exhibits classical conditioning when a weak tactile stimulus to the siphon is used as a conditioned stimulus and a strong shock to the tail is used as an unconditioned stimulus. The siphon withdrawal component of this reflex can be differentially conditioned when stimuli applied to two different sites on the mantle skin (the mantle shelf and the siphon) are used as discriminative stimuli. The differential conditioning can be acquired in a single trial, is retained for more than 24 hours, and increases in strength with increased trials. Differential conditioning can also be produced within the field of innervation of a single cluster of sensory neurons (the LE cluster) since two separate sites on the siphon skin can serve as discriminative stimuli. The finding that two independent afferent inputs that activate a common set of interneurons and motor neurons can be differentially conditioned restricts the possible cellular loci involved in the associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carew, T J -- Hawkins, R D -- Kandel, E R -- 5KO2 M0081/PHS HHS/ -- 5KO5 MH18558/MH/NIMH NIH HHS/ -- NS 12744/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):397-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681571" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Aplysia/*physiology ; Conditioning, Classical/*physiology ; *Defense Mechanisms ; Humans ; Memory ; Reflex
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  • 57
    Publication Date: 1983-01-28
    Description: A commercial alpha-amylase inhibitor with potent inhibitory activity in vitro was used in a randomized double-blind, cross-over clinical trial in six nonobese, healthy adult males. In these subjects, this inhibitor had no effect on the response of blood glucose, insulin, or breath hydrogen to a standardized starch meal. It is concluded that this formulation has no effect on starch digestion in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlson, G L -- Li, B U -- Bass, P -- Olsen, W A -- 5P30 AM 26659/AM/NIADDK NIH HHS/ -- AM 13927/AM/NIADDK NIH HHS/ -- AM 21668/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):393-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6184780" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/*antagonists & inhibitors ; Blood Glucose/metabolism ; Dietary Carbohydrates/*metabolism ; Humans ; Hydrogen/metabolism ; Insulin/blood ; alpha-Amylases/*antagonists & inhibitors
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  • 58
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charrow, R P -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857235" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic/*legislation & jurisprudence ; Drug Industry ; *Drug Prescriptions ; Humans ; United States
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  • 59
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-26
    Description: The rate of increase of population in less developed countries accelerated rapidly from 1850 to 1960 because of a rapid decline in mortality while fertility remained high. In the 1960's, the birth rate as a whole began to decline more rapidly than the death rate--very rapidly in some populations, most notably that of China, more gradually in others, and not at all in some of the poorest populations. The momentum of growth implies continued increase in populations for several decades even in countries where fertility has fallen the most, and very large additional increases where there has been no decline in the rate of childbearing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coale, A J -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):828-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879179" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Birth Rate ; *Developing Countries ; Female ; *Fertility ; Humans ; Marriage ; Parity ; Pregnancy
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  • 60
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, Barbara J -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1029.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643993" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Fraud ; Humans ; *Research ; Research Personnel ; *Scientific Misconduct
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  • 61
    Publication Date: 1983-07-01
    Description: Mammalian atrial extracts possess natriuretic and diuretic activity. In experiments reported here it was found that atrial, but not ventricular, extract also causes relaxation of isolated vascular and nonvascular smooth muscle preparations. The smooth muscle relaxant activity of atrial extract was heat-stable and concentration-dependent and could be destroyed with protease. Rabbit aortic and chick rectum strips were used for the detection of atrial biological activity. The atrial activity was separated by column chromatography into two peaks having apparent molecular weights of 20,000 to 30,000 and less than 10,000. The atrial substance that copurified with the smooth muscle relaxant activity in both peaks caused natriuresis when injected into conscious rats. It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, M G -- Geller, D M -- Cole, B R -- Boylan, J G -- YuSheng, W -- Holmberg, S W -- Needleman, P -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Chickens ; Chromatography, Gel ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Molecular Weight ; Muscle, Smooth/drug effects ; Muscle, Smooth, Vascular/*drug effects ; Natriuresis/drug effects ; Rabbits ; Rats ; Swine ; Vasodilation/drug effects
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  • 62
    Publication Date: 1983-07-08
    Description: A diffusible factor produced and secreted by malignant murine cells was capable of inducing plasminogen activator production by normal diploid human fibroblasts. The factor's ability to induce plasminogen activator was insensitive to treatment with nucleases, but its activity was destroyed by digestion with proteases. It is proposed that such a factor would play a role in malignancy if it would recruit normal cells that were adjacent to transformed cells to produce plasminogen activator which could result in tumor-promoted proteolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, R L -- Rifkin, D B -- Tepper, R -- Miller, A -- Kucherlapati, R -- CA-16239/CA/NCI NIH HHS/ -- CA-35171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Fibroblasts/drug effects/metabolism ; Humans ; Hybrid Cells/metabolism ; Melanoma/metabolism ; Mice ; Neoplasms, Experimental/*metabolism/secretion ; Peptides/pharmacology/*secretion ; Plasminogen Activators/*biosynthesis ; Rats
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  • 63
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The external and internal interosseous intercostal muscles were separately stimulated at end-expiratory lung volume in anesthetized dogs. These muscles were all found to elevate the ribs into which they insert. By attaching weights to the ribs, it was determined that the nonlinear compliance of the ribs was responsible for this phenomenon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Troyer, A -- Kelly, S -- Zin, W A -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):87-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Dogs ; Electric Stimulation ; Humans ; Intercostal Muscles/anatomy & histology/*physiology ; Respiration ; Ribs/anatomy & histology/*physiology
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  • 64
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dermer, G B -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):318.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; *Neoplasms ; Neoplasms, Experimental ; Rats ; Research
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  • 65
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeSimone, J A -- NS13767/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):221-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828892" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diffusion ; Humans ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism/*physiology ; Peptides/metabolism ; Sucrose/metabolism
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-15
    Description: Artificial intelligence, long a topic of basic computer science research, is now being applied to problems of scientific, technical, and commercial interest. Some consultation programs, although limited in versatility, have achieved levels of performance rivaling those of human experts. A collateral benefit of this work is the systematization of previously unformalized knowledge in areas such as medical diagnosis and geology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duda, R O -- Shortliffe, E H -- LM-00048/LM/NLM NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6340198" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; *Computers ; Diagnosis, Computer-Assisted ; Humans ; Research ; Systems Analysis
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  • 67
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-09
    Description: Nonmalignant diploid human fibroblast cells (GM3498B) derived from a skin biopsy of a patient with Bloom's syndrome have been transformed by transfection with DNA from a tumorigenic mouse cell line (Ha-8) carrying a single copy of the Harvey murine sarcoma virus (Ha-MuSV) genome. The transformed cell lines have an extended life-span, form colonies in agarose, and proliferate in nude mice--characteristics of neoplastic transformation. Like the parental cells, they also exhibit a high spontaneous level of sister chromatid exchanges. Finally, the transformed cells contain most, if not all, of the Ha-MuSV genome as well as the human rasH sequence. These experiments show that these diploid nonmalignant human cells can be used as recipients in transfection experiments for studying the genetic control of neoplastic transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doniger, J -- Di Paolo, J A -- Popescu, N C -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1144-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648529" target="_blank"〉PubMed〈/a〉
    Keywords: Bloom Syndrome/*genetics ; Cell Adhesion ; *Cell Transformation, Neoplastic ; Cells, Cultured ; DNA, Neoplasm/*genetics ; Humans ; Oncogenes ; Transfection
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doverspike, Dennis -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):506.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644015" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavioral Research ; Civil Rights ; Ethics, Professional ; Human Rights ; Humans ; *Research ; *Research Personnel ; *Scientific Misconduct ; *Social Control, Informal ; Students ; *Universities
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: The forensic use of hypnosis is increasing. A hypermnesic procedure was used in an experiment that calls this practice into question. Subjects tried for a week to recall 60 previously presented pictures. They were then either hypnotized or not and encouraged to recall even more pictures. Most of the newly recalled material was incorrect, especially for highly hypnotizable subjects in the hypnosis condition. Such errors in recall can have profound implications for forensic investigations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dywan, J -- Bowers, K -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):184-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623071" target="_blank"〉PubMed〈/a〉
    Keywords: Forensic Psychiatry/methods ; Humans ; *Hypnosis ; Memory/*physiology ; Mental Recall/*physiology
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  • 70
    Publication Date: 1983-12-23
    Description: Subfreezing temperatures, low light levels, and high doses of ionizing and ultraviolet radiation extending for many months after a large-scale nuclear war could destroy the biological support systems of civilization, at least in the Northern Hemisphere. Productivity in natural and agricultural ecosystems could be severely restricted for a year or more. Postwar survivors would face starvation as well as freezing conditions in the dark and be exposed to near-lethal doses of radiation. If, as now seems possible, the Southern Hemisphere were affected also, global disruption of the biosphere could ensue. In any event, there would be severe consequences, even in the areas not affected directly, because of the interdependence of the world economy. In either case the extinction of a large fraction of the Earth's animals, plants, and microorganisms seems possible. The population size of Homo sapiens conceivably could be reduced to prehistoric levels or below, and extinction of the human species itself cannot be excluded.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrlich, P R -- Harte, J -- Harwell, M A -- Raven, P H -- Sagan, C -- Woodwell, G M -- Berry, J -- Ayensu, E S -- Ehrlich, A H -- Eisner, T -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1293-300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658451" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Climate ; *Environment ; Humans ; *Nuclear Warfare ; Photosynthesis ; Radiation, Ionizing ; Radioactive Fallout ; Sunlight ; Temperature ; Ultraviolet Rays
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  • 71
    Publication Date: 1983-09-02
    Description: Extracts from adult human adrenals contained high concentrations of immunoreactive beta-endorphin and alpha-melanotropin. Lower quantities of immunoreactive adrenocorticotropic hormone could also be detected. Distribution studies showed the presence of pro-opiomelanocortin fragments in the adrenal medulla. No alpha-melanotropin, beta-endorphin, or adrenocorticotropic hormone could be found in adrenal extracts from several other mammalian species. Analysis of the beta-endorphin-like immunoreactivity using region specific radioimmunoassays interfacing with gel filtration and reverse-phase high-performance liquid chromatography showed the majority of the beta-endorphin-like material to exist as nonacetylated beta-endorphin-(1-31) with a small percentage of lipotropin-sized molecules. The alpha-melanotropin-like immunoreactivity cochromatographed on gel filtration and reverse-phase high-performance liquid chromatography with desacetyl alpha-melanotropin. The data suggest that pro-opiomelanocortin is expressed in the adrenal medulla of humans but is not detectable in the adrenal glands of many other mammalian species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, C J -- Erdelyi, E -- Weber, E -- Barchas, J D -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):957-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308766" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/analysis ; Adrenal Medulla/*analysis ; Adrenocorticotropic Hormone/analysis ; Endorphins/analysis ; Humans ; Melanocyte-Stimulating Hormones/analysis ; Pituitary Hormones, Anterior/*analysis/metabolism ; Pro-Opiomelanocortin ; Protein Precursors/*analysis/metabolism ; Radioimmunoassay
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  • 72
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-23
    Description: Three-month-old infants learned to activate an overhead crib mobile by operant footkicking and received a visual reminder of the event (a "reactivation treatment") 2 weeks later, after forgetting had occurred. Subsequent manifestation of the association was a monotonic increasing function of time since the reactivation treatment, and performance of infants tested 8 hours after the remainder was related to the time spent sleeping in the interim (r = 0.75). These data demonstrate that normal retrieval is time-dependent. Moreover, individual data suggest that retrieval may be continuous rather than discontinuous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fagen, J W -- Rovee-Collier, C -- MH 32307/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658456" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Infant ; *Memory ; Time Factors
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  • 73
    Publication Date: 1983-05-20
    Description: The acquired immune deficiency syndrome (AIDS), which has recently occurred at increasing rates in homosexual men, intravenous drug users, and others, is characterized by the development of Kaposi's sarcoma and several opportunistic infections including pneumonia caused by Pneumocystis carinii. Serum samples from patients with AIDS and from matched and unmatched control subjects were examined for the presence of antibodies to cell membrane antigens associated with human T-cell leukemia virus. Nineteen of 75 of the AIDS patients had antibodies directed to surface antigens of Hut 102, a reference T lymphoid cell line infected with leukemia virus, as did two of the 336 control subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Essex, M -- McLane, M F -- Lee, T H -- Falk, L -- Howe, C W -- Mullins, J I -- Cabradilla, C -- Francis, D P -- 2T32CA09031/CA/NCI NIH HHS/ -- 5T32HL07523/HL/NHLBI NIH HHS/ -- CA 18216/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 20;220(4599):859-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6342136" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/etiology/immunology/*microbiology ; Animals ; Antibodies, Viral/*analysis ; Antigens, Viral/immunology ; Female ; Fluorescent Antibody Technique ; Humans ; Lymphatic Diseases/immunology ; Male ; *Retroviridae/immunology ; T-Lymphocytes/microbiology ; Tumor Virus Infections/complications/immunology/*microbiology
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  • 74
    Publication Date: 1983-09-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1161-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612329" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Dioxins/*toxicity ; Environmental Exposure ; Humans
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  • 75
    Publication Date: 1983-07-29
    Description: Markedly elevated nighttime concentrations of serotonin in rhesus monkey cerebrospinal fluid were reduced to daytime levels by exposing the monkeys to continuous light or to the beta-adrenergic antagonist propranolol. Nighttime elevations of melatonin in cerebrospinal fluid were also suppressed by propranolol and light. Serotonin released in large quantities at night appears to be regulated like melatonin, and may act as a cerebroventricular hormone to influence brain and pituitary function at night.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garrick, N A -- Tamarkin, L -- Taylor, P L -- Markey, S P -- Murphy, D L -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):474-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6683428" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Circadian Rhythm/drug effects ; Humans ; *Light ; Macaca mulatta ; Male ; Melatonin/physiology ; Propranolol/*pharmacology ; Rats ; Serotonin/*cerebrospinal fluid/physiology
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  • 76
    Publication Date: 1983-05-20
    Description: The acquired immune deficiency syndrome (AIDS) is characterized by T-lymphocyte dysfunction and is frequently accompanied by opportunistic infections and Kaposi's sarcoma. Human T-cell leukemia virus (HTLV) is associated with T-cell malignancies and can transform T lymphocytes in vitro. In an attempt to find evidence of HTLV infection in patients with AIDS, DNA from samples of peripheral blood lymphocytes from 33 AIDS patients was analyzed by Southern blot-hybridization with a radiolabeled cloned HTLV DNA probe. Analysis of DNA from both the fresh (uncultured) lymphocytes and from T cells cultured with T-cell growth factor revealed the presence of integrated HTLV proviral sequences in lymphocytes from two of the patients, both of whom had antibody to HTLV. The proviral sequences could not be detected in blood samples obtained from these individuals at a later date, consistent with the possibility that the population of infected cells had become depleted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelmann, E P -- Popovic, M -- Blayney, D -- Masur, H -- Sidhu, G -- Stahl, R E -- Gallo, R C -- New York, N.Y. -- Science. 1983 May 20;220(4599):862-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6601822" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/etiology/immunology/*microbiology ; Adult ; Animals ; Cats ; DNA, Viral/*analysis ; Humans ; Male ; Middle Aged ; *Retroviridae/genetics ; T-Lymphocytes/analysis/microbiology ; Tumor Virus Infections/complications/*microbiology
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-23
    Description: Giardia lamblia, a common pathogenic intestinal parasite of humans, was rapidly killed by exposure to normal human milk in vitro. The killing did not depend on secretory immunoglobulin A. Entamoeba histolytica, the dysentery amoeba, was also killed by normal human milk. Giardia-cidal activity cochromatographed with an unusual lipase that is present in the milk of humans but not of lower mammals. Human milk may play a protective role in infants exposed to this parasite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gillin, F D -- Reiner, D S -- Wang, C S -- AI19863/AI/NIAID NIH HHS/ -- HD14104/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1290-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310751" target="_blank"〉PubMed〈/a〉
    Keywords: Entamoeba histolytica/growth & development ; Entamoebiasis/prevention & control ; Female ; Giardia/growth & development ; Giardiasis/*prevention & control ; Humans ; Immunoglobulin A, Secretory/immunology ; Intestines/parasitology ; Milk, Human/*parasitology ; Trichomonas Infections/prevention & control ; Trichomonas vaginalis/growth & development
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glenn, L L -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):527-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623095" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Brain Stem/physiology ; Electric Stimulation ; Heart/*innervation ; Humans ; Locomotion ; Lung/*innervation ; *Respiration
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-15
    Description: Behavior of squirrel monkeys, maintained by the termination of stimuli associated with electric shock, was suppressed by response-dependent shock delivery. The effects of pentobarbital on this behavior depended on whether monkeys had previously received morphine. In monkeys without experience with drugs, pentobarbital increased responding. In monkeys with recent experience with morphine, however, pentobarbital resulted in a smaller increase or decrease in responding. The rate-decreasing effects of pentobarbital after a history of morphine administration could be reversed by the administration of d-amphetamine. These findings suggest that the behavioral effects of abused drugs may depend on previous experience with other drugs, even when those drugs are from a different pharmacological class.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glowa, J R -- Barrett, J E -- DA 02658/DA/NIDA NIH HHS/ -- DA 02873/DA/NIDA NIH HHS/ -- MH 07658/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):333-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682244" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Dextroamphetamine/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Humans ; Macaca mulatta ; Male ; Morphine/pharmacology ; Pentobarbital/*pharmacology ; Saimiri ; Substance-Related Disorders/physiopathology
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  • 80
    Publication Date: 1983-07-08
    Description: In the parafoveal retina of human observers, cone-mediated sensitivity to flicker decreases as rods become progressively more dark-adapted. This effect is greatest when a rod response to flicker is precluded. These results indicate that rods tonically inhibit cone pathways in the dark.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, S H -- Frumkes, T E -- Nygaard, R W -- EY01802/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):180-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857279" target="_blank"〉PubMed〈/a〉
    Keywords: Dark Adaptation ; Flicker Fusion/physiology ; Humans ; Neural Inhibition ; Photoreceptor Cells/*physiology ; Retina/*physiology
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  • 81
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: The Lewy body, a histological hallmark of Parkinson's disease, is a filamentous inclusion residing most prominently in pigmented neurons of the brainstem. Immunocytochemical reactions of Lewy bodies were examined with antisera to several filamentous proteins of the nervous system and positive reactions were found with those against neurofilaments. An abnormal organization of the neuronal cytoskeleton may be a pathological feature of Parkinson's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, J E -- Yen, S H -- Chiu, F C -- Peress, N S -- AG 01136/AG/NIA NIH HHS/ -- NS 02476/NS/NINDS NIH HHS/ -- NS 17125/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1082-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308771" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens/analysis ; Brain/ultrastructure ; Histocytochemistry ; Humans ; Immunoenzyme Techniques ; Inclusion Bodies/*analysis/immunology ; Intermediate Filament Proteins/*analysis/immunology ; Parkinson Disease/*pathology
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  • 82
    Publication Date: 1983-07-22
    Description: Young deaf children who were unable to acquire oral language naturally and who had not been exposed to a conventional manual language were found to use spontaneously a gesture system that has some of the structural characteristics of early child language. The structural aspects of this gesture system appeared to be neither modeled for the child by the gestures of an adult nor shaped by the responses of an adult. These findings suggest that the child may contribute to structural aspects of the system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldin-Meadow, S -- Mylander, C -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):372-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867713" target="_blank"〉PubMed〈/a〉
    Keywords: Child Language ; Child, Preschool ; Communication ; Deafness/*psychology ; Humans ; Infant ; *Language Development ; *Manual Communication ; Parent-Child Relations ; *Sign Language
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-05
    Description: Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorman, C -- Padmanabhan, R -- Howard, B H -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306768" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avian Sarcoma Viruses/genetics ; Cell Line ; Cercopithecus aethiops ; Cricetinae ; Cricetulus ; DNA, Recombinant/*metabolism ; Genetic Vectors ; HeLa Cells/metabolism ; Humans ; Mice ; Plasmids ; *Transfection
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  • 84
    Publication Date: 1983-04-08
    Description: Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused the formation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grafstrom, R C -- Fornace, A J Jr -- Autrup, H -- Lechner, J F -- Harris, C C -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828890" target="_blank"〉PubMed〈/a〉
    Keywords: Bronchi/*cytology/drug effects ; Cells, Cultured ; *DNA/biosynthesis ; DNA Repair/*drug effects ; Epithelium/drug effects ; Fibroblasts/drug effects ; Formaldehyde/*pharmacology ; Humans
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: Consistency of hand preference was examined in a longitudinal study of children between 18 and 42 months of age. Results showed a sex-specific relationship between hand consistency and intellectual development. Across a variety of intellectual abilities at all ages, females with consistency of handedness were precocious compared to females without such consistency. This relationship did not hold for males.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottfried, A W -- Bathurst, K -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879205" target="_blank"〉PubMed〈/a〉
    Keywords: Child, Preschool ; Female ; *Functional Laterality ; Humans ; Infant ; *Intelligence ; Intelligence Tests ; Male ; Sex Factors ; Time Factors
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: In vitro fertilization, in its first 5 years of use, has met minimum standards for efficacy and safety, as judged by published clinical reports. It is becoming more widely available as an approach for overcoming sterility in married couples and appears also to be gaining social acceptance in that context. Several technical options presented by the procedure, particularly storage of frozen embryos and embryo transfers involving third-party contributions, are less fully evaluated clinically and raise social, ethical, and legal questions that go beyond the original medical model for therapeutic intervention. The clinical success of in vitro fertilization and the options it affords call for careful policy consideration. Estimates of costs and of potential demand for and supply of services are provided and the current status of relevant policy in the United States and abroad is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grobstein, C -- Flower, M -- Mendeloff, J -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):127-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623063" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Costs and Cost Analysis ; Embryo Transfer ; Ethical Review ; Ethics ; Fallopian Tube Diseases/therapy ; Federal Government ; Female ; Fertilization in Vitro/*methods ; Humans ; Infertility, Female/therapy ; Infertility, Male/therapy ; Legislation, Medical ; Male ; Obstetrics/economics/standards ; Oocyte Donation ; Pregnancy ; Resource Allocation ; *Risk Assessment ; during its first five years. Efficacy, safety, costs, demand and supply, and ; feasible extensions of the basic procedure are discussed. The authors contend ; that, while Australia and Great Britain have made progress toward formulating ; public policy on IVF, efforts in the United States have not gone beyond a 1979 ; report and recommendations issued by the Department of Health, Education, and ; Welfare's Ethics Advisory Board. Given the ready clinical and public acceptance ; of IVF, there is need for an oversight mechanism at the federal level, perhaps ; via a forum concerned also with the overlapping area of human genetic ; intervention.
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: Neutrophils, especially in acute infection or the myeloid leukemias, may shed platelet-sized particles that can readily be distinguished from true platelets because they contain neutrophil myeloperoxidase. This enzyme, unlike platelet peroxidase, is not inhibited by glutaraldehyde. The myeloperoxidase and acid hydrolase levels and continuous plasma membranes of these cell-like particles suggest that they are functional cellular entities. They further differ from platelets in that they contain nuclear remnants, occur in bacteria-laden pus and inflammatory exudates, are ingested by macrophages, and do not adhere to each other or aggregate. They could be involved in the immune response to pathogens or contribute to trauma and healing by facilitating deployment of neutrophil acid hydrolase, neutral protease, and myeloperoxidase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanker, J S -- Giammara, B L -- DE 02668/DE/NIDCR NIH HHS/ -- DE 05333/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):415-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301006" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Cells/*cytology/physiology ; Blood Platelets/*cytology/physiology ; Cell Nucleus/physiology ; Humans ; Inflammation/physiopathology ; Microscopy, Electron ; Neutrophils/*cytology/physiology ; Peroxidase
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  • 88
    Publication Date: 1983-04-15
    Description: Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibody-producing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-specific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas other recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haspel, M V -- Onodera, T -- Prabhakar, B S -- Horita, M -- Suzuki, H -- Notkins, A L -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301002" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology/*microbiology ; Endocrine Glands/*immunology ; Enzyme-Linked Immunosorbent Assay ; Growth Hormone/immunology ; Humans ; Hybridomas/immunology ; Mice ; Pituitary Gland, Anterior/immunology ; Rats ; Reoviridae Infections/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heath, C W Jr -- Nadel, M R -- Zack, M M -- Chen, A T -- Bender, M A -- Preston, R J -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):908.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879190" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Aberrations ; Humans ; New York ; Water Pollutants/*adverse effects ; Water Pollutants, Chemical/*adverse effects
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  • 90
    Publication Date: 1983-06-24
    Description: The size of the Epstein-Barr virus (EBV) nuclear antigen (EBNA) in cells infected with different EBV isolates varies directly with the size of the EBV triplet repeat array, IR3. The isolate with the largest IR3 fragment has approximately 170 more codons than the isolates with the smallest IR3 fragment; it encodes an EBNA which is approximately 17,000 daltons larger than the smallest EBNA. The EBV IR3 encodes part of a 2-kilobase exon of a latently infected cell messenger RNA which must be translated into a repetitive amino acid domain of EBNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hennessy, K -- Heller, M -- van Santen, V -- Kieff, E -- CA 17281/CA/NCI NIH HHS/ -- CA 19264/CA/NCI NIH HHS/ -- GM 07183/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1396-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304878" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/*genetics ; Base Sequence ; Cell Nucleus/immunology ; DNA, Viral/*genetics ; Epstein-Barr Virus Nuclear Antigens ; Herpesvirus 4, Human/*genetics/immunology ; Humans ; Mice ; RNA, Viral/genetics
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-02-11
    Description: Plasmids were constructed to direct synthesis of the human interferons IFN-alpha 1, IFN-alpha 2, and IFN-gamma in the yeast Saccharomyces cerevisiae. Expression of IFN genes containing coding sequences for secretion signals resulted in the secretion of IFN activity. A large proportion of the IFN-alpha 1 and IFN-alpha 2 isolated from the yeast cell growth media had the same amino termini as the natural mature interferons, suggesting a removal of the signal sequences identical to that of human cells. These results show that a lower eukaryote, such as yeast, can utilize and process a human signal sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hitzeman, R A -- Leung, D W -- Perry, L J -- Kohr, W J -- Levine, H L -- Goeddel, D V -- New York, N.Y. -- Science. 1983 Feb 11;219(4585):620-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186023" target="_blank"〉PubMed〈/a〉
    Keywords: Cloning, Molecular ; Gene Expression Regulation ; Humans ; Interferons/*genetics/secretion ; Peptides/physiology ; Plasmids ; Protein Processing, Post-Translational ; Protein Sorting Signals ; RNA Processing, Post-Transcriptional ; Saccharomyces cerevisiae/genetics
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  • 92
    Publication Date: 1983-04-08
    Description: Influenza A viruses (subtype H1N1), recently isolated from turkeys in different areas of the United States, were determined to be closely related to strains typically associated with pigs. This conclusion was based on comparisons of H1N1 isolates from pigs, humans, ducks, and turkeys with polyclonal and monoclonal antibodies, RNA-RNA competitive hybridization, and replication studies. One of the H1N1 isolates from turkeys caused influenza in a laboratory technician, who displayed fever, respiratory illness, virus shedding, and seroconversion. These results suggest that turkeys as well as pigs are involved in the maintenance of these viruses and their transmission to humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hinshaw, V S -- Webster, R G -- Bean, W J -- Downie, J -- Senne, D A -- AI-02649/AI/NIAID NIH HHS/ -- AI-08831/AI/NIAID NIH HHS/ -- AI-16841/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):206-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6298942" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/immunology ; Antigens, Viral/immunology ; Ducks/microbiology ; Ferrets/immunology ; Humans ; Influenza A virus/immunology/*isolation & purification ; Orthomyxoviridae Infections/*transmission ; Poultry Diseases/microbiology ; RNA, Viral/metabolism ; Swine/microbiology ; Turkeys/*microbiology
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  • 93
    Publication Date: 1983-06-03
    Description: The eye movements of human subjects were experimentally modified while they were awake to determine the effect of waking experience on electroculographic activity during rapid eye movement (REM) sleep. After normal eye movements were monitored under controlled conditions, subjects spent 5 days wearing goggles that contained minification lenses and that curtailed vision to a 5 degree field. The amplitude and frequency of eye movements decreased when subjects were awake and increased during REM sleep; sleep stage durations and distributions were unaffected. Values returned to normal in the first 24 hours of recovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herman, J H -- Roffwarg, H P -- MH 3414/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844929" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Electrooculography ; *Eye Movements ; Humans ; Oculomotor Muscles/physiology ; Sleep, REM/*physiology ; Wakefulness/*physiology
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  • 94
    Publication Date: 1983-05-06
    Description: A simple and efficient method of covalently coupling the strong chelator diethylenetriaminepentaacetic acid to proteins was developed for radiolabeling immunoglobulin G antibodies. After being coupled and labeled with indium-111, a monoclonal antibody to carcinoembryonic antigen retained its ability to bind to its antigen in vitro and in vivo. In nude mice with a human colorectal xenograft, 41 percent of the injected radioactivity became localized in each gram of xenograft at 24 hours compared with 9 percent for control antibody and 19 percent for radioiodinated antibody to carcinoembryonic antigen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hnatowich, D J -- Layne, W W -- Childs, R L -- Lanteigne, D -- Davis, M A -- Griffin, T W -- Doherty, P W -- 1 RO1 CA26968/CA/NCI NIH HHS/ -- 1 RO1 GM26780/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):613-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836304" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibodies, Monoclonal/immunology ; Carcinoembryonic Antigen/immunology ; Chromatography, High Pressure Liquid ; Humans ; Immunoglobulin G/immunology ; Isotope Labeling/*methods ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Transplantation ; Pentetic Acid
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The thickness of intact human red cell membrane is measured by a light-microscope technique in which membrane material with a known surface area is extracted into a long, thin cylindrical strand. The radius of the strand is calculated from its known length and surface area. The minimum radius, obtained at high extraction velocities or large membrane tensions, is 55 angstroms. A collapsed membrane cylinder with a mean-mass radius of 55 angstroms would have a membrane thickness of 78 angstroms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hochmuth, R M -- Evans, C A -- Wiles, H C -- McCown, J T -- HL 23728/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):101-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828875" target="_blank"〉PubMed〈/a〉
    Keywords: Erythrocyte Membrane/*ultrastructure ; Erythrocytes/*ultrastructure ; Humans ; Mathematics ; Microscopy
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-04
    Description: Efforts in estimating carcinogenic risk in humans from long-term exposure to chemical carcinogens have centered on the problem of low-dose extrapolation. For chemicals with metabolites that interact with DNA, it may be more meaningful to relate tumor response to the concentration of the DNA adducts in the target organ rather than to the applied dose. Many data suggest that the relation between tumor response and concentration of DNA adducts in the target organ may be linear. This implies that the nonlinearities of the dose-response curve for tumor induction may be due to the kinetic processes involved in the formation of carcinogen metabolite--DNA adducts. Of particular importance is the possibility that the kinetic processes may show a nonlinear "hockey-stick" like behavior which results from saturation of detoxification or DNA repair processes. The mathematical models typically used for low-dose extrapolation are shown potentially to overestimate risk by several orders of magnitude when nonlinear kinetics are present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoel, D G -- Kaplan, N L -- Anderson, M W -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1032-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823565" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens/*administration & dosage ; Cell Transformation, Neoplastic/*drug effects ; DNA, Neoplasm/genetics ; Dose-Response Relationship, Drug ; Humans ; Kinetics ; Models, Biological ; Neoplasms/*chemically induced ; Risk
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: Technological hazards are evaluated in terms of quantitatively expressed physical, biological, and social descriptors. For each hazard a profile is constructed that considerably extends the conventional definition of risk. The profile, which is termed hazardousness, was understood in pilot experiments on perception and appeared to capture a large fraction of lay people's concern with hazard. It also suggests an orderly method for establishing priorities for the management of hazards.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hohenemser, C -- Kates, R W -- Slovic, P -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):378-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836279" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Exposure ; *Environmental Health ; Humans ; Risk ; *Technology ; Triage
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1216-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648530" target="_blank"〉PubMed〈/a〉
    Keywords: *Ethics, Medical ; Humans ; *Infant, Newborn ; Life Support Care ; Organizations ; *Patient Advocacy ; Pediatrics ; Societies, Medical ; *Withholding Treatment ; handicapped newborns has issued a statement of "Principles of Treatment of ; Disabled Infants." The statement reaffirms the rights of ill and disabled ; newborns and appears to preclude quality of life considerations in decisions ; concerning medical care. Interpretation of the principles varies among the ; signatories, however, with the American Academy of Pediatrics differing from the ; Association for Retarded Citizens in its construction of phrases such as "limited ; potential" and "clearly futile" surgery.
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):908.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6227081" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Multiple ; Civil Rights ; *Disabled Persons ; Federal Government ; Female ; *Government Regulation ; Humans ; Infant, Newborn ; *Judicial Role ; *Jurisprudence ; United States ; *Withholding Treatment ; Department of Justice suit in November 1983 against the State University Hospital ; in Stony Brook, New York, to obtain the infant's medical records. Parents and ; physicians had decided against treatment for the severely handicapped newborn, ; but legal action was begun by right-to-life advocates to appoint a guardian for ; the child and to order surgery. The Department of Justice became involved after ; two New York courts ruled against the action ; the Department's intervention is ; based on Section 504 of the Rehabilitation Act, which forbids discrimination ; against the handicapped.
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  • 100
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):994-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648520" target="_blank"〉PubMed〈/a〉
    Keywords: American Medical Association ; *Forensic Psychiatry ; Humans ; *Mental Disorders ; United States
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