Publication Date:
1988-12-23
Description:
The contributions of two subclasses of excitatory amino acid transmitter receptors to the induction and expression of long-term potentiation (LTP) were analyzed in hippocampal slices. The quisqualate/kainate receptor antagonist DNQX (6,7-dinitro-quinoxaline-2,3-dione) blocked 85% of the evoked field potential, leaving a small response that was sensitive to D-AP5 (D-2-amino-5-phosphonopentanoate), an N-methyl-D-aspartate (NMDA) receptor blocker. This residual D-AP5-sensitive response was of comparable size in control and previously potentiated inputs. High-frequency stimulation in the presence of DNQX did not result in the development of robust LTP. Washout of the drug, however, revealed the potentiation effect. Thus NMDA-mediated responses can induce, but are not greatly affected by, LTP; non-NMDA receptors, conversely, mediate responses that are not needed to elicit LTP but that are required for its expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, D -- Joly, M -- Lynch, G -- New York, N.Y. -- Science. 1988 Dec 23;242(4886):1694-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2904701" target="_blank"〉PubMed〈/a〉
Keywords:
2-Amino-5-phosphonovalerate
;
Animals
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Electric Conductivity
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Electric Stimulation
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Evoked Potentials/drug effects
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Hippocampus/*physiology
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Magnesium/pharmacology
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Male
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Membrane Potentials/drug effects
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Quinoxalines/pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, AMPA
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter/drug effects/*physiology
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Synapses/*physiology
;
Valine/analogs & derivatives/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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