Publication Date:
1981-11-27
Description:
The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lozovsky, D -- Saller, C F -- Kopin, I J -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1031-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6458088" target="_blank"〉PubMed〈/a〉
Keywords:
Alloxan/pharmacology
;
Animals
;
Blood Glucose/metabolism
;
Cell Membrane/metabolism
;
Corpus Striatum/*metabolism
;
Diabetes Mellitus, Experimental/drug therapy/*metabolism
;
Insulin/therapeutic use
;
Kinetics
;
Male
;
Rats
;
Rats, Inbred Strains
;
Receptors, Dopamine/drug effects/*metabolism
;
Spiperone/metabolism
;
Streptozocin/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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