Publication Date:
1981-12-11
Description:
An animal model of tardive dyskinesia was used to evaluate the potential antidyskinetic properties of the neuropeptide L-prolyl-L-leucyl-glycinamide (PLG). In rats, PLG administered concurrently with the neuroleptic drug haloperidol or chlorpromazine antagonized the enhancement of specific [3H]spiroperidol binding in the striatum that is associated with long-term neuroleptic treatment. The results are discussed in relation to a possible functional coupling of the putative PLG receptor with neuroleptic-dopamine receptor complex and clinical implications for tardive dyskinesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiu, S -- Paulose, C S -- Mishra, R K -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1261-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117947" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Butyrophenones/*metabolism
;
Chlorpromazine/*pharmacology
;
Corpus Striatum/*metabolism
;
Haloperidol/*pharmacology
;
Kinetics
;
MSH Release-Inhibiting Hormone/*pharmacology
;
Male
;
Rats
;
Rats, Inbred Strains
;
Receptors, Dopamine/drug effects/*metabolism
;
Spiperone/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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