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  • Pregnancy  (46)
  • Cricetinae  (39)
  • American Association for the Advancement of Science (AAAS)  (84)
  • 1980-1984  (84)
  • 1984  (43)
  • 1982  (41)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (84)
  • Springer  (4)
Years
  • 1980-1984  (84)
Year
  • 1
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    Sensitivity to carcinogenesis in nude mice: skin tumors caused by transplacental exposure to ethylnitrosourea (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Female athymic nude mice and their phenotypically normal littermates were exposed transplacentally to ethylnitrosourea. Skin tumors (papillomas and sebaceous adenomas) developed on the nude mice with an almost tenfold greater incidence than on their haired littermates. Skin tumors were also induced on nude mice but not haired controls by direct intraperitoneal treatment with ethylnitrosourea. These results indicate that nude mice have higher than normal susceptibility to carcinogenesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, L M -- Last-Barney, K -- Budinger, J M -- CA 08748/CA/NCI NIH HHS/ -- CA 22498/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):682-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134965" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/chemically induced ; Animals ; *Ethylnitrosourea ; Female ; *Maternal-Fetal Exchange ; Mice ; Mice, Nude/*physiology ; Neoplasms, Experimental/chemically induced ; *Nitrosourea Compounds ; Pregnancy ; Sebaceous Gland Neoplasms/chemically induced ; Skin Neoplasms/*chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Exposure of rats to cimetidine during intrauterine life and the immediate neonatal period results in hypoandrogenization in adult life with decreased weights of androgen-dependent tissues and decreased concentrations of testosterone. Moreover, sexual behavior patterns in adult life are disturbed as shown by a lack of sexual motivation and decreased performance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anand, S -- Van Thiel, D H -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):493-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123252" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Animals ; Animals, Suckling ; Cimetidine/metabolism/*toxicity ; Female ; Guanidines/*toxicity ; Male ; Pregnancy ; Pregnancy, Animal/drug effects ; Rats ; Sex Differentiation/*drug effects ; Sexual Behavior, Animal/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: Golden Syrian hamsters were placed individually in cages with three drinking bottles--one empty, one containing water, and the third containing water and ethanol. Control hamsters received water only. After 1 year the experimental hamsters showed a significantly lower concentration of leucine-enkephalin-like immunoreactive substance in the basal ganglia than the control hamsters. This finding indicates that the action of ethanol involves endogenous peptidyl opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blum, K -- Briggs, A H -- Elston, S F -- DeLallo, L -- Sheridan, P J -- Sar, M -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1425-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basal Ganglia/*drug effects ; Cricetinae ; Endorphins/*analysis ; Enkephalin, Leucine ; Enkephalins/*analysis/metabolism ; Ethanol/metabolism/*pharmacology ; Mesocricetus ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Reversal of morphine disruption of maternal behavior by concurrent treatment with the opiate antagonist naloxone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: Rats whose pregnancies were surgically terminated on day 17 of gestation were injected with morphine, morphine plus naloxone hydrochloride, or saline, and then tested for maternal responsiveness toward foster young. Morphine treatment alone significantly disrupted the rate of onset and quality of maternal responsiveness. Concurrent administration of naloxone to morphine-injected rats reinstated the rapid onset of behavioral responsiveness toward foster young, such that the responsiveness of the rats treated with both morphine and naloxone was indistinguishable from that shown by saline-injected controls. The disruptive effects of morphine did not appear to result from a general reduction in activity levels as measured in an open-field apparatus. These findings suggest that the normal onset and maintenance of maternal behavior in the rat may be regulated by endogenous opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bridges, R S -- Grimm, C T -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Drug Antagonism ; Female ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Pregnancy ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-06
    Description: Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bump, E A -- Yu, N Y -- Brown, J M -- CA-15201/CA/NCI NIH HHS/ -- CM-87207/CM/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):544-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089580" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anoxia ; Cell Survival/drug effects/*radiation effects ; Cells, Cultured ; Cricetinae ; Cricetulus ; Drug Synergism ; Glutathione/*metabolism ; Maleates/administration & dosage ; Mice ; Mice, Inbred BALB C ; Misonidazole/administration & dosage ; Neoplasms, Experimental/metabolism ; *Oxygen Consumption
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Development of mouse embryos in vitro: preimplantation to the limb bud stage (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Mouse embryos were grown successfully in vitro from the blastocyst stage to the limb bud stage. Mouse blastocysts grown in vitro for 10 days showed blood circulation in the yilk sac, forelimb buds, and the primordia of liver, pancreas, and lungs. These characteristics are indicative of a developmental stage equivalent to one-half of the total gestation period in utero. Improvements in culture conditions from days 7 to 9 have made it feasible to culture mouse blastocysts beyond the early somite stage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, L T -- Hsu, Y C -- AM 19535/AM/NIADDK NIH HHS/ -- AM 28550/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123220" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/*physiology ; Cell Differentiation ; Culture Media ; Culture Techniques ; Embryo, Mammalian/*physiology ; Female ; Fetal Blood ; Humans ; Mice ; Pregnancy ; Yolk Sac/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Serum from monkeys with histories of fetal wastage causes abnormalities in cultured rat embryos (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, N W -- Plenefisch, J D -- Carey, S W -- Fredrickson, W T -- Sackett, G P -- Burbacher, T M -- Parker, R M -- HD02774/HD/NICHD NIH HHS/ -- HD08633/HD/NICHD NIH HHS/ -- RR00166/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):66-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053560" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Veterinary/*blood ; Animals ; Congenital Abnormalities/*etiology ; Ectogenesis ; Female ; Macaca nemestrina/blood ; Mice ; Pregnancy ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 8
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    Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-08
    Description: A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antogonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nekola, M B -- Horvath, A -- Ge, L J -- Coy, D H -- Schally, A V -- HD-0-2831/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):160-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750790" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Female ; Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology ; Luteinizing Hormone/secretion ; Ovulation/*drug effects ; Pregnancy ; Proestrus/drug effects ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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  • 9
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    Pregnancy suppression by active immunization against gestation-specific riboflavin carrier protein (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-09
    Description: A riboflavin carrier protein isolated from chickens cross-reacts with a gestation-specific rodent carrier for riboflavin. Active immunization of female rats of proved fertility with the purified chicken carrier protein completely yet reversibly suppressed early pregnancy without impairing implantation per se. Concurrently there were no discernible adverse effects on maternal health in terms of weight gain, vitamin status, and fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murty, C V -- Adiga, P R -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):191-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063879" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Carrier Proteins/*immunology ; Female ; Fetal Resorption/immunology ; Flavins/blood ; Glutathione Reductase/blood ; Immunization ; *Membrane Transport Proteins ; Pregnancy ; *Pregnancy, Animal ; Progesterone/blood ; Rats
    Print ISSN: 0036-8075
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  • 10
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    Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: When ethanol was administered intravenously to pregnant monkeys, a transient but marked collapse of umbilical vasculature was observed uniformly within about 15 minutes. The ethanol-induced impairment of umbilical circulation produced severe hypoxia and acidosis in the fetus; recovery occurred during the succeeding hour. This striking interruption of feto-placental circulation may explain one of the mechanisms of mental retardation, a frequent manifestation in children afflicted with fetal alcohol syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukherjee, A B -- Hodgen, G D -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):700-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890235" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaldehyde/blood ; Animals ; Disease Models, Animal ; Ethanol/blood/*pharmacology ; Female ; Fetal Alcohol Spectrum Disorders/*etiology ; Fetal Distress/*chemically induced ; Macaca fascicularis ; Macaca mulatta ; Pregnancy ; Pregnancy, Animal/*drug effects ; Umbilical Cord/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Lung fibrosis and emphysema: divergent responses to a common injury? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: Cadmium chloride, administered intratracheally to golden Syrian hamsters, causes an acute lung injury which evolves into a lesion with functional and morphological features of diffuse fibrosis. With simultaneous feeding of a lathyrogen, beta-aminoproprionitrile, this same injury evolves into functional and morphological changes of bullous emphysema. These results suggest that the same lung injury might result in either fibrosis or emphysema, connective tissue synthesis during the healing phase being the critical determinant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niewoehner, D E -- Hoidal, J R -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):359-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089570" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopropionitrile/pharmacology ; Animals ; Cadmium/pharmacology ; Cadmium Chloride ; Collagen/biosynthesis ; Connective Tissue/metabolism ; Cricetinae ; Elastin/biosynthesis ; Female ; Intubation, Intratracheal ; Lung/pathology ; Mesocricetus ; Pulmonary Emphysema/*chemically induced/pathology ; Pulmonary Fibrosis/*chemically induced/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Norethisterone, a major ingredient of contraceptive pills, is a suicide inhibitor of estrogen biosynthesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: Norethisterone (17 alpha-ethynyl-19-nortestosterone) is an effective irreversible inhibitor of estrogen synthetase (aromatase), the enzyme responsible for the conversion of androgens to estrogens, even at a 2 X 10(-6) molar concentration. This irreversible inactivation, which is directed toward the active site of aromatase and requires the cofactor-reduced nicotinamide adenine dinucleotide phosphate, is both time- and concentration-dependent. Ethisterone (17 alpha-ethynyltestosterone), in contrast, is not a suicide inhibitor of aromatase even at concentrations of 10(-4) molar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osawa, Y -- Yarborough, C -- HDO4945/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1249-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058343" target="_blank"〉PubMed〈/a〉
    Keywords: *Aromatase Inhibitors ; Binding Sites/drug effects ; Contraceptives, Oral/*pharmacology ; Estrogens/*biosynthesis ; Female ; Humans ; Kinetics ; Microsomes/enzymology ; Norethindrone/*pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Placenta/enzymology ; Pregnancy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearson, R D -- Manian, A A -- Harcus, J L -- Hall, D -- Hewlett, E L -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):369-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124040" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antipsychotic Agents/*pharmacology/therapeutic use ; Chlorpromazine/pharmacology ; Cricetinae ; Humans ; Leishmania/*drug effects ; Leishmaniasis, Visceral/*drug therapy ; Macrophages/microbiology ; Mesocricetus
    Print ISSN: 0036-8075
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  • 14
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    Influence of female hormonal state on rhesus sexual behavior varies with space for social interaction (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: The sexual behavior of rhesus monkeys in 15 male-female pairings was observed in both a large and a small area during the follicular and luteal phases of the female's cycle. Males ejaculated in all tests at the follicular phase of the female's cycle and in 53 percent of tests at the luteal phase. However, a significant decline in ejaculation during tests at the luteal phase occurred in the large, but not in the small area. Thus the degree to which the pair's sexual behavior was influenced by the female's hormonal state depended on the spatial conditions of the test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wallen, K -- MH35835/MH/NIMH NIH HHS/ -- RR-00165/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):375-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7201164" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Copulation ; Ejaculation ; *Estrus ; Female ; Macaca/*physiology ; Macaca mulatta/*physiology ; Male ; Pregnancy ; Proestrus ; Sexual Behavior, Animal/*physiology ; Social Behavior ; *Spatial Behavior
    Print ISSN: 0036-8075
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  • 15
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    Human fetal movement: spontaneous oscillations near one cycle per minute (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: Spectral analysis of spontaneous fluctuations in human fetal movement revealed strong oscillations at frequencies between 0.24 and 0.90 cycle per minute, which are much higher than those of the cyclic alternation of quiet and active states in the fetus and neonate. Oscillations at frequencies up to 2.88 cycles per minute were also detected, but they were usually much weaker. The prominent peaks in the fetal movement spectra are in the frequency range of recently reported neonatal motor rhythms, and indicate the existence of a cyclic process controlling spontaneous motor output that oscillates near one cycle per minute and begins to function in utero.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robertson, S S -- Dierker, L J -- Sorokin, Y -- Rosen, M G -- M01RR00210/RR/NCRR NIH HHS/ -- P50HD11089/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1327-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146916" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Fetus/*physiology ; Humans ; *Movement ; Pregnancy ; Pregnancy Trimester, Third ; Spectrum Analysis/methods ; Time Factors
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  • 16
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    Congenital malformations induced by laetrile (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-19
    Description: Laetrile administered orally ot pregnant hamsters caused skeletal malformations in the offspring, but intravenous laetrile filed to result in embryopathic effects. Oral laetrile significantly increased in situ cyanide concentrations, while intravenous laetrile did not. Thiosulfate administration protected embryos from the teratogenic effects of oral laetrile. The embryopathic effects of oral laetrile appear to be due to cyanide released by bacterial beta-glucosidase activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willhite, C C -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1513-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063858" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Administration, Oral ; Amygdalin/administration & dosage/metabolism/*toxicity ; Animals ; Cricetinae ; Female ; Injections, Intravenous ; Pregnancy
    Print ISSN: 0036-8075
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  • 17
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    Avian pancreatic polypeptide phase shifts hamster circadian rhythms when microinjected into the suprachiasmatic region (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-24
    Description: The suprachiasmatic nucleus has been identified tentatively as a circadian pacemaker. To examine the functional role of peptides found within suprachiasmatic neurons, avian pancreatic polypeptide and vasopressin were microinjected into the suprachiasmatic region. Avian pancreatic polypeptide, but not vasopressin, shifted the phase of the wheelrunning rhythm as a function of the time of its injection within the circadian cycle. Avian pancreatic polypeptide or a similar peptide may be one component of the neurochemical processes underlying entrainment to the light-dark cycle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Albers, H E -- Ferris, C F -- Leeman, S E -- Goldman, B D -- GM-31199/GM/NIGMS NIH HHS/ -- HD-18022/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):833-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6546454" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds ; Cerebral Ventricles/drug effects ; *Circadian Rhythm ; Cricetinae ; Motor Activity/drug effects ; Nerve Tissue Proteins/pharmacology ; Neuropeptide Y ; Pancreatic Polypeptide/*pharmacology ; Species Specificity ; Suprachiasmatic Nucleus/*drug effects ; Vasopressins/pharmacology
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  • 18
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    Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-12
    Description: A novel eukaryotic hybrid gene has been constructed from the 5' sequence of a rat gene and the bacterial neomycin-resistance gene. After transfection into hamster fibroblasts, the neo transcripts can be induced to high levels by the absence of glucose. Furthermore, this hybrid gene can be regulated by temperature when it is introduced into a temperature-sensitive mutant cell line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Attenello, J W -- Lee, A S -- CA-27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 12;226(4671):187-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484570" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cricetinae ; DNA, Recombinant ; Drug Resistance, Microbial ; Fibroblasts ; *Gene Expression Regulation ; Genes, Bacterial ; *Genes, Regulator ; Glucose/*pharmacology ; *HSP70 Heat-Shock Proteins ; Membrane Proteins/biosynthesis/*genetics ; Mutation ; Neomycin/pharmacology ; Rats ; Temperature ; Transcription, Genetic ; Transfection
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-06
    Description: Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonner, T -- O'Brien, S J -- Nash, W G -- Rapp, U R -- Morton, C C -- Leder, P -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):71-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691137" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/genetics ; Animals ; Chromosome Aberrations ; Chromosome Mapping ; *Chromosomes, Human, 1-3 ; *Chromosomes, Human, 4-5 ; Cricetinae ; Humans ; Hybrid Cells ; Kidney Neoplasms/genetics ; Lung Neoplasms/genetics ; Male ; Mice ; Nucleic Acid Hybridization ; *Oncogenes
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  • 20
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    Differential NK cell and macrophage killing of hamster cells infected with nononcogenic or oncogenic adenovirus (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: Hamster cells infected with highly oncogenic human adenovirus type 12 (Ad12) were resistant to lysis by natural killer cells and macrophages, compared to cells infected with nononcogenic adenovirus type 2 (Ad2). The data suggest that early adenovirus gene expression in hamster cells results in preferential survival of Ad12, compared to Ad2, infected cells in vivo, thus providing an explanation for the differences in the oncogenicities of these two transforming viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, J L -- Lewis, A M Jr -- CA 31732/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 May 11;224(4649):612-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710160" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/*immunology ; Animals ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Viral ; Cricetinae ; Humans ; Immunity, Cellular ; Killer Cells, Natural/*physiology ; Macrophages/*physiology ; Mesocricetus ; Oncogenic Viruses/*immunology ; Rats
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  • 21
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    Regressive events in neurogenesis (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-21
    Description: The development of most regions of the vertebrate nervous system includes a distinct phase of neuronal degeneration during which a substantial proportion of the neurons initially generated die. This degeneration primarily adjusts the magnitude of each neuronal population to the size or functional needs of its projection field, but in the process it seems also to eliminate many neurons whose axons have grown to either the wrong target or an inappropriate region within the target area. In addition, many connections that are initially formed are later eliminated without the death of the parent cell. In most cases such process elimination results in the removal of terminal axonal branches and hence serves as a mechanism to "fine-tune" neuronal wiring. However, there are now also several examples of the large-scale elimination of early-formed pathways as a result of the selective degeneration of long axon collaterals. Thus, far from being relatively minor aspects of neural development, these regressive phenomena are now recognized as playing a major role in determining the form of the mature nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowan, W M -- Fawcett, J W -- O'Leary, D D -- Stanfield, B B -- EY-03653/EY/NEI NIH HHS/ -- NS-18506/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1258-65.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474175" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Brain/*growth & development ; Cricetinae ; *Nerve Degeneration ; Nerve Growth Factors/pharmacology ; Nervous System/*growth & development ; Purkinje Cells/physiology ; Rats ; Retina/growth & development ; Superior Colliculi/growth & development ; Synapses/physiology ; Visual Pathways/growth & development
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  • 22
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    Cell biology of synaptic plasticity (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-09-21
    Description: The nervous system of mammals retains throughout the animals' life-span the ability to modify the number, nature, and level of activity of its synapses. Synaptic plasticity is most evident after injury to the nervous system, and the cellular and molecular mechanisms that make it possible are beginning to be understood. Transplantation of brain tissue provides a powerful approach for studying mechanisms of synaptic plasticity. In turn, understanding the response of the central nervous system to injury can be used to optimize transplant survival and integration with the host brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cotman, C W -- Nieto-Sampedro, M -- AG 00538/AG/NIA NIH HHS/ -- MH 19691/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1287-94.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382610" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Brain/*growth & development/*physiology ; Cerebral Cortex/physiology/transplantation ; Denervation ; Female ; Humans ; Nerve Regeneration ; *Neuronal Plasticity ; Peripheral Nerves/physiology ; Pregnancy ; Synapses/*physiology
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  • 23
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    Test-tube embryology in the dock (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickson, D -- New York, N.Y. -- Science. 1984 Aug 10;225(4662):606.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740327" target="_blank"〉PubMed〈/a〉
    Keywords: *Embryo Research ; Embryo Transfer ; Embryo, Mammalian ; Female ; Fertilization in Vitro ; *Government Regulation ; Great Britain ; Humans ; *Legislation, Medical ; Oocyte Donation ; Pregnancy ; special license be required for all embryo experimentation and that any ; unlicensed research be considered a criminal offense. Regulation would be by a ; new statutory body responsible for monitoring in vitro fertilization research and ; various types of fertility treatments. Surrogate motherhood would be prohibited. ; Reservations expressed by professional groups as well as by some committee ; members about the restrictions reflect legal and social problems surrounding the ; uses of human embryos.
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  • 24
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    Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibson, M J -- Krieger, D T -- Charlton, H M -- Zimmerman, E A -- Silverman, A J -- Perlow, M J -- 1RO1NS20335/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):949-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382608" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Chemistry ; Cerebral Ventricles/pathology ; *Copulation ; Female ; Hypogonadism/genetics/pathology/*physiopathology ; Infertility, Female/etiology/*therapy ; Male ; Mice ; Neurons/analysis ; Ovulation ; Pituitary Hormone-Releasing Hormones/analysis/*deficiency ; Pregnancy ; Preoptic Area/*transplantation ; *Reproduction
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  • 25
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    Replication timing of genes and middle repetitive sequences (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-18
    Description: DNA replication in mammals is temporally bimodal. "Housekeeping" genes, which are active in all cells, replicate during the first half of the S phase of cell growth. Tissue-specific genes replicate early in those cells in which they are potentially expressed, and they usually replicate late in tissues in which they are not expressed. Replication during the first half of the S phase is, therefore, a necessary but not sufficient condition for gene transcription. A change in the replication timing of a tissue-specific gene appears to reflect the commitment of that gene to transcriptional competence or to quiescence during ontogeny. Most families of middle repetitive sequences replicate either early or late. These data are consistent with a model in which two functionally distinct genomes coexist in the nucleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, M A -- Holmquist, G P -- Gray, M C -- Caston, L A -- Nag, A -- GM 07526/GM/NIGMS NIH HHS/ -- GM23905/GM/NIGMS NIH HHS/ -- K04 HD 00323/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 May 18;224(4650):686-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719109" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Chromatin/physiology ; Cricetinae ; DNA/physiology ; *DNA Replication ; *Genes ; HeLa Cells/metabolism ; Humans ; Nucleic Acid Hybridization ; *Repetitive Sequences, Nucleic Acid ; Replicon ; Transcription, Genetic
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  • 26
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    Studying learning in the womb (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):302-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740312" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Fetus/*physiology ; Humans ; Infant, Newborn ; Infant, Premature ; Learning/*physiology ; Male ; Pregnancy ; Rats
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  • 27
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    High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-06
    Description: A rapid gene-mapping system uses a high-resolution, dual-laser sorter to identify genes from separate human chromosomes prepared with a new stain combination. This system was used to sort 21 unique chromosome types onto nitrocellulose filter papers. Several labeled gene probes hybridized to the sorted chromosomal DNA types predicted by their previous chromosome assignments. The skeletal muscle glycogen phosphorylase gene was then mapped to a portion of chromosome 11 by spot blotting normal and translocated chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lebo, R V -- Gorin, F -- Fletterick, R J -- Kao, F T -- Cheung, M C -- Bruce, B D -- Kan, Y W -- AM32822/AM/NIADDK NIH HHS/ -- HD02081/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):57-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587566" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosome Mapping ; *Chromosomes, Human, 6-12 and X ; Cricetinae ; Cricetulus ; DNA/*metabolism ; Glycogen Storage Disease/*genetics ; Glycogen Storage Disease Type V/*genetics ; Humans ; Hybrid Cells ; Karyotyping ; Male ; Nucleic Acid Hybridization ; Phosphorylases/genetics
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  • 28
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    Transfection of the DNA polymerase-alpha gene (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-11-16
    Description: DNA polymerase-alpha is the major replicative DNA polymerase in animal cells. The gene coding for a mutant DNA polymerase-alpha was transferred from one cell to another by transfection of DNA from mutant cells. The DNA was isolated from a mutant hamster cell line resistant to aphidicolin, a specific inhibitor of DNA polymerase-alpha, and transferred into an aphidicolin-sensitive cell line. The resulting transfectants exhibited increased survival in the presence of aphidicolin and contained an aphidicolin-resistant DNA polymerase-alpha.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, P K -- Loeb, L A -- CA07418/CA/NCI NIH HHS/ -- CA24845/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):833-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436977" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aphidicolin ; Cell Line ; Clone Cells ; Cricetinae ; Cricetulus/genetics ; DNA Polymerase II/*genetics ; Diterpenes/pharmacology ; Escherichia coli/genetics ; Humans ; Mice ; Mutation ; Salmon/genetics ; *Transfection
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  • 29
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    Prenatal exposure to carbon monoxide: learning and memory deficits (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-27
    Description: Exposing pregnant rats to carbon monoxide (150 parts per million) produced only minor reductions in the birth weights of the pups and gave no evidence of overt teratogenesis. However, behavioral evaluation of learning and memory processes in a two-way avoidance task suggested a functional deficit in the central nervous system of the exposed offspring. Multiple dependent measures and specific control groups confirmed that this deficit was independent of nonassociative or motivational alterations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mactutus, C F -- Fechter, L D -- ES 01589/ES/NIEHS NIH HHS/ -- ES 07094/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 27;223(4634):409-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/*drug effects ; Birth Weight/drug effects ; Carbon Monoxide/*toxicity ; Conditioning (Psychology) ; Female ; Male ; Memory/*drug effects ; Pregnancy ; *Prenatal Exposure Delayed Effects ; Rats
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  • 30
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    Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-17
    Description: Antisera to a synthetic c-myc peptide and to c-myc antigens synthesized from various portions of the human gene expressed in Escherichia coli were used in order to characterize the protein product of the human c-myc oncogene. Although the deduced molecular weight of the human c-myc protein is 49,000, these antisera precipitate a protein from human cells that migrates in sodium dodecyl sulfate-polyacrylamide gel as if its molecular weight were 65,000. In addition, the mouse c-myc protein, whether synthesized in cells or in a cell-free system directed by pure, synthetic messenger RNA, has analogous properties and is immunoprecipitated by the antiserum to the human c-myc protein. Similar proteins are immunoprecipitated from monkey, rat, hamster, and frog cells, suggesting evolutionary conservation of antigenic structure of the c-myc protein among vertebrates. In addition, and in a manner consistent with the behavior of its messenger RNA, the immunoprecipitable c-myc protein is sharply induced by the action of mitogens on resting human T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Persson, H -- Hennighausen, L -- Taub, R -- DeGrado, W -- Leder, P -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):687-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6431612" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Neoplasm/*immunology ; Base Sequence ; *Cell Division ; Chickens ; Cricetinae ; DNA, Neoplasm/genetics ; DNA, Recombinant/metabolism ; Electrophoresis, Polyacrylamide Gel ; Haplorhini ; Humans ; Mice ; Mitogens/pharmacology ; Molecular Weight ; Neoplasm Proteins/genetics/*immunology ; *Oncogenes ; RNA, Messenger/genetics ; Rabbits ; Rats
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  • 31
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    Interferon-beta-related DNA is dispersed in the human genome (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-03-23
    Description: Interferon-beta 1 (IFN-beta 1) complementary DNA was used as a hybridization probe to isolate human genomic DNA clones lambda B3 and lambda B4 from a human genomic DNA library. Blot-hybridization procedures and partial nucleotide sequencing revealed that lambda B3 is related to IFN-beta 1 (and more distantly to IFN-alpha 1). Analyses of DNA obtained from a panel of human-rodent somatic cell hybrids that were probed with DNA derived from lambda B3 showed that lambda B3 is on human chromosome 2. Similar experiments indicated that lambda B4 is not on human chromosomes 2, 5, or 9. The finding that DNA related to the IFN-beta 1 gene (and IFN-alpha 1 gene) is dispersed in the human genome raises new questions about the origins of the interferon genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sagar, A D -- Sehgal, P B -- May, L T -- Inouye, M -- Slate, D L -- Shulman, L -- Ruddle, F H -- AI-16262/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1312-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6546621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human/*analysis ; Chromosomes, Human, 1-3 ; Chromosomes, Human, 4-5 ; Chromosomes, Human, 6-12 and X ; Cloning, Molecular ; Cricetinae ; DNA/*analysis ; *Genes ; Humans ; Hybrid Cells ; Interferon Type I/*genetics ; Mice ; Nucleic Acid Hybridization
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  • 32
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    Lymphokine production by cultured human T cells transformed by human T-cell leukemia-lymphoma virus-I (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-17
    Description: Cell-free conditioned media from human T cells transformed by human T-cell leukemia-lymphoma virus (HTLV-I) were tested for the production of soluble biologically active factors, including several known lymphokines. The cell lines used were established from patients with T-cell leukemia-lymphoma and from human umbilical cord blood and bone marrow leukocytes transformed by HTLV-I in vitro. All of the cell lines liberated constitutively one or more of the 12 biological activities assayed. These included macrophage migration inhibitory factor (MIF), leukocyte migration inhibitory factor (LIF), leukocyte migration enhancing factor (MEF), macrophage activating factor (MAF), differentiation inducing factor (DIF), colony stimulating factor (CSF), eosinophil growth and maturation activity (eos. GMA), fibroblast activating factor (FAF), gamma-interferon and, in rare instances, T-cell growth factor (TCGF). Some cell lines produced interleukin 3 (IL-3), platelet-derived growth factor (PDGF), or B-cell growth factors (BCGF). Such cells should prove useful for the production of lymphokines and as sources of specific messenger RNA's for their genetic cloning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salahuddin, S Z -- Markham, P D -- Lindner, S G -- Gootenberg, J -- Popovic, M -- Hemmi, H -- Sarin, P S -- Gallo, R C -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):703-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320367" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal ; Antigens, Neoplasm/analysis ; Bone Marrow ; Cell Line ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Deltaretrovirus/*genetics ; Female ; Humans ; Leukemia/*microbiology ; Lymphokines/*biosynthesis ; Lymphoma/*microbiology ; Phenotype ; Pregnancy ; T-Lymphocytes/*immunology
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    Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chafouleas, J G -- Bolton, W E -- Means, A R -- RR-05425/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6203171" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bleomycin/*pharmacology ; Calmodulin/*antagonists & inhibitors/*physiology ; Cell Division/drug effects ; Cell Line ; Cell Survival/drug effects ; Cricetinae ; Cricetulus ; DNA Repair/*drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Sulfonamides/pharmacology
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    Cardiac atria of BIO 14.6 hamsters are deficient in natriuretic factor (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-24
    Description: The hearts of 220-day-old hamsters of the BIO 14.6 strain are deficient in atrial natriuretic factor; saline extracts of atria produce one-third the natriuretic and diuretic effects of extracts of atria from age-matched normal hamsters. BIO 14.6 hamsters are known to develop congestive heart failure with edema when they are about 200 days old, and the venous congestion and edema are preventable by parabiosis with normal hamsters. The humoral mediator, the deficiency of which causes venous congestion and edema in BIO 14.6 hamsters, may be atrial natriuretic factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chimoskey, J E -- Spielman, W S -- Brandt, M A -- Heidemann, S R -- HL01010/HL/NHLBI NIH HHS/ -- HL07404/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):820-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6538050" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Cardiomyopathy, Dilated/*physiopathology ; Cricetinae ; Disease Models, Animal ; Heart Failure/*physiopathology ; *Natriuresis ; Natriuretic Agents ; *Protein Deficiency ; Water-Electrolyte Balance
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    VA study of twins may be canceled (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):521.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387909" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects ; 2,4-Dichlorophenoxyacetic Acid/adverse effects ; Combat Disorders/psychology ; Female ; Humans ; Pregnancy ; Tetrachlorodibenzodioxin/adverse effects ; *Twins/psychology ; United States ; *United States Department of Veterans Affairs ; *Veterans ; Vietnam
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  • 36
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    Vasopressin injected into the hypothalamus triggers a stereotypic behavior in golden hamsters (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-04
    Description: Microinjection of arginine vasopressin into the medial preoptic area of the hypothalamus of male and female golden hamsters triggered a complex, stereotypic behavior--flank marking--a type of scent marking used in olfactory communication. The flank marking was not elicited by saline, oxytocin, neurotensin, or angiotensin II. Vasopressin was ineffective when injected into other areas of the hypothalamus or into the lateral cerebroventricle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, C F -- Albers, H E -- Wesolowski, S M -- Goldman, B D -- Luman, S E -- GM-31199/GM/NIGMS NIH HHS/ -- HD-18022/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 May 4;224(4648):521-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6538700" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensin II/pharmacology ; Animals ; Arginine Vasopressin/*pharmacology ; Castration ; Cerebral Ventricles/drug effects ; Cricetinae ; Female ; Grooming/drug effects ; Humans ; Hypothalamus/drug effects ; Hypothalamus, Middle/drug effects ; Light ; Male ; Mesocricetus ; Microinjections ; Neurotensin/pharmacology ; Oxytocin/pharmacology ; Preoptic Area/*drug effects ; Stereotyped Behavior/*drug effects
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  • 37
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    Human chorionic gonadotropin secreted by preimplantation embryos cultured in vitro (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-24
    Description: Human oocytes were collected by laparoscopy and fertilized and cultured in vitro. Human chorionic gonadotropin was detected in the medium surrounding two embryos cultured for more than 7 days after fertilization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishel, S B -- Edwards, R G -- Evans, C J -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):816-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6546453" target="_blank"〉PubMed〈/a〉
    Keywords: Blastocyst/*physiology ; Chorionic Gonadotropin/*secretion ; *Embryonic Development ; Female ; Fertilization in Vitro ; Humans ; Pregnancy ; Trophoblasts/physiology
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  • 38
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    Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: Treatment of mice with the carcinogen N-methylnitrosourea results in the development of thymic lymphomas with frequent involvement of the N-ras oncogene. The activated mouse N-ras gene was isolated from one of these lymphomas and, by transformation in concert with restriction digestion, a map of the gene was prepared and its approximate boundaries were determined. By means of somatic cell hybrids the normal N-ras gene was found to be unlinked to other members of the ras gene family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero, I -- Villasante, A -- D'Eustachio, P -- Pellicer, A -- CA-16239/CA/NCI NIH HHS/ -- GM-32105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1041-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089339" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic ; Chromosome Mapping ; Cloning, Molecular ; Cricetinae ; DNA Restriction Enzymes ; Deoxyribonuclease EcoRI ; Genetic Linkage ; Hybrid Cells ; Lymphoma/chemically induced/*genetics ; Methylnitrosourea ; Mice ; Mice, Inbred Strains ; *Oncogenes ; Thymus Neoplasms/chemically induced/*genetics
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    VA to study twins (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1157.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6367037" target="_blank"〉PubMed〈/a〉
    Keywords: Combat Disorders/epidemiology ; Female ; Humans ; Male ; *Military Medicine ; Pregnancy ; *Twins ; United States ; United States Department of Veterans Affairs ; *Veterans ; Vietnam ; *Warfare
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  • 40
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    Perinatal dopamine-related drugs demasculinize rats (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: Administration of haloperidol, a common neuroleptic, to pregnant or lactating rats impaired the masculine sex behavior of their male offspring. Prenatal haloperidol did not affect testosterone concentrations in fetuses. Maternal administration of apomorphine, a dopamine agonist, and of alpha-methyl-p-tyrosine, an inhibitor of dopamine synthesis, also demasculinized male offspring. In both experiments other behaviors and developmental milestones were unaffected. Perinatal haloperidol, apomorphine, and alpha-methyl-p-tyrosine did not lower testosterone in adulthood. These drugs may act directly on neurons that control masculine behavior without lowering testosterone prenatally or in adulthood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hull, E M -- Nishita, J K -- Bitran, D -- Dalterio, S -- 2S07RR0706618/RR/NCRR NIH HHS/ -- HD 16329/HD/NICHD NIH HHS/ -- MH 3593901/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):1011-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719125" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Apomorphine/pharmacology ; Dopamine/*physiology ; Ejaculation/drug effects ; Female ; Haloperidol/*pharmacology ; Male ; Methyltyrosines/pharmacology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats ; Receptors, Dopamine/drug effects ; Sexual Behavior, Animal/*drug effects/physiology ; Testosterone/blood
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  • 41
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    Phosphorylation events during Mullerian duct regression (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-10
    Description: Regression of the fetal rat Mullerian duct in vitro was stimulated by sodium fluoride in the absence of Mullerian inhibiting substance. The action of Mullerian inhibiting substance was inhibited by sodium vanadate, adenosine 5'-triphosphate, and several related nucleotides in the presence of manganese ions. Epidermal growth factor specifically inhibited the substance, but only with manganese ions present. Insulin, platelet-derived growth factor, and nerve growth factor had no effect. These results suggest that dephosphorylation of membrane proteins mediates the action of Mullerian inhibiting substance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hutson, J M -- Fallat, M E -- Kamagata, S -- Donahoe, P K -- Budzik, G P -- CA-17393/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):586-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6607531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Mullerian Hormone ; Cations, Divalent ; Dimethyl Sulfoxide/pharmacology ; Epidermal Growth Factor/pharmacology ; Female ; *Glycoproteins ; *Growth Inhibitors ; Kinetics ; Male ; Membrane Proteins/metabolism ; Mullerian Ducts/drug effects/*physiology ; Phosphorylation ; Pregnancy ; Rats ; Sodium Fluoride/pharmacology ; Testicular Hormones/*physiology ; Vanadates ; Vanadium/pharmacology
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  • 42
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    Inhibition of human estrogen synthetase (aromatase) by flavones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes. These flavones include (in order of decreasing potency) 7,8-benzoflavone, chrysin, apigenin, flavone, flavanone, and quercetin; 5,6-benzoflavone was not inhibitory. 7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement. Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kellis, J T Jr -- Vickery, L E -- AM1005/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1032-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474163" target="_blank"〉PubMed〈/a〉
    Keywords: Androstenedione/*metabolism ; *Aromatase Inhibitors ; Benzoflavones/metabolism/pharmacology ; Binding Sites ; Binding, Competitive ; Female ; Flavonoids/metabolism/*pharmacology ; Humans ; Kinetics ; Microsomes/enzymology ; Ovary/*enzymology ; Oxidoreductases/*antagonists & inhibitors ; Placenta/*enzymology ; Pregnancy ; Testosterone/*metabolism ; beta-Naphthoflavone
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    Tumor-prone mice--and myc (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):823.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494912" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Mice ; Mice, Mutant Strains/*genetics ; Neoplasms, Experimental/*genetics ; *Oncogenes ; Pregnancy
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  • 44
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    Prenatal alcohol exposure alters adult expression of sexually dimorphic behavior in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Saccharin preference and performance in a Lashley III maze were found to be altered in adult male and female rats that had been exposed to alcohol during gestation. Specifically, the sexual dimorphism normally observed in both behaviors was absent in fetal alcohol-exposed animals. The lack of sexual dimorphism appeared to result from a masculinization of the exposed females and a feminization of the exposed males.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGivern, R F -- Clancy, A N -- Hill, M A -- Noble, E P -- AA-03513/AA/NIAAA NIH HHS/ -- AA05174/AA/NIAAA NIH HHS/ -- MH08645/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 May 25;224(4651):896-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719121" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Discrimination Learning/drug effects ; Ethanol/*adverse effects ; Female ; Food Preferences/drug effects ; Gestational Age ; Male ; Pregnancy ; *Prenatal Exposure Delayed Effects ; Rats ; Saccharin ; *Sex Characteristics
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  • 45
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    Infection-specific particle from the unconventional slow virus diseases (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-27
    Description: Scrapie-associated fibrils, first observed in brains of scrapie-infected mice, were also observed in scrapie-infected hamsters and monkeys, in humans with Creutzfeldt-Jakob disease, and in kuru-infected monkeys. These fibrils were not found in a comprehensive series of control brains from humans and animals affected with central nervous system disorders resulting in histopathologies, ultrastructural features, or disease symptoms similar to those of scrapie, kuru, and Creutzfeldt-Jakob disease. These fibrils are also found in preclinical scrapie and in the spleens of scrapie-infected mice; they are a specific marker for the "unconventional" slow virus diseases, and may be the etiological agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merz, P A -- Rohwer, R G -- Kascsak, R -- Wisniewski, H M -- Somerville, R A -- Gibbs, C J Jr -- Gajdusek, D C -- AGO4220/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 27;225(4660):437-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6377496" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/pathology ; Amyloid/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Brain/drug effects/ultrastructure ; Creutzfeldt-Jakob Syndrome/pathology ; Cricetinae ; Cuprizone/pharmacology ; Humans ; Kuru/pathology ; Mice ; Mice, Inbred C57BL ; Parkinson Disease/pathology ; Saimiri ; Scrapie/pathology ; Sheep ; Slow Virus Diseases/*pathology ; Spleen/ultrastructure ; Triethyltin Compounds/pharmacology
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  • 46
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    Monoclonal antibody to a human germ cell membrane glycoprotein that inhibits fertilization (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: A monoclonal antibody to an antigen in the human germ cell membrane did not agglutinate or immobilize sperm but inhibited binding and penetration of zona-free hamster ova by human sperm and blocked murine fertilization in vitro. The antibody, of the 2a subclass of immunoglobulin G, was germ cell-specific but not species-specific. It recognized a single antigen of 23 kilodaltons that has been isolated from human germ cells. This fertilization antigen, located on the postacrosome , midpiece, and tail of human sperm, is a glycoprotein of testicular origin associated with some types of human involuntary immunoinfertility .〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naz, R K -- Alexander, N J -- Isahakia, M -- Hamilton, M S -- HD-14572/HD/NICHD NIH HHS/ -- HD-16608/HD/NICHD NIH HHS/ -- RR-00163/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):342-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6539947" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Cricetinae ; Female ; *Fertilization ; Humans ; Hybridomas/immunology ; Male ; Membrane Proteins/*immunology ; Mice ; Mice, Inbred BALB C ; Ovum/immunology ; Spermatozoa/*immunology
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  • 47
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    Sindbis virus mutants selected for rapid growth in cell culture display attenuated virulence in animals (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-27
    Description: Mutants of Sindbis virus were selected for rapid growth in baby hamster kidney (BHK) cell cultures and screened for attenuation of virulence in suckling mice. Comparisons among independently isolated virulent and attenuated strains, as well as a classical reversion analysis, showed that accelerated penetration of BHK cells was correlated with attenuation in vivo. Both phenotypic changes resulted from a reorganization of virion structure as detected by monoclonal antibodies. These results suggest that mutants selected for rapid growth in cell culture may be useful as attenuated vaccines and for studies of the molecular basis of virus pathogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olmsted, R A -- Baric, R S -- Sawyer, B A -- Johnston, R E -- AI19433/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 27;225(4660):424-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6204381" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Viral/immunology ; Cells, Cultured ; Cricetinae ; Kidney/cytology ; Mice ; Mutation ; Neutralization Tests ; RNA/biosynthesis ; Sindbis Virus/genetics/growth & development/immunology/*pathogenicity ; Togaviridae Infections/microbiology
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  • 48
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    Anomalous patterns in cultured cell monolayers (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: Gridlike patterns of differing cell density were observed in evenly seeded cell monolayers. Such patterns were obtained in five of six cell lines tested, suggesting widespread occurrence. The mechanism appears to involve small, transient temperature changes related to incubator tray structure. The very short time course of appearance of the patterns implicates attachment rather than growth as the critically affected factor. Impaired adhesion or directed sedimentation resulting from thermally induced microcurrents in the medium are the two most likely mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, E M -- Flunk, L J -- Mullin, J M -- Kleinzeller, A -- 2 T32 GM07229-07/GM/NIGMS NIH HHS/ -- AM 12619-13/AM/NIADDK NIH HHS/ -- HL07027-07/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7048529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Count ; Cell Line ; Cells, Cultured/*cytology ; Cricetinae ; *Cytological Techniques ; Dogs ; Mice ; Temperature
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    Simultaneous expression of globin genes for embryonic and adult hemoglobins during mammalian ontogeny (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-17
    Description: The dominant hemoglobin of the adult hamster was detected in yolk-sac erythroid cells, and its identity was confirmed by peptide mapping and by analysis of relevant peptides. Both the presence and active synthesis of two embryonic hemoglobins presumed to exist only in yolk-sac erythroid cells were detected in neonatal liver and spleen. Thus the time span of expression of both embryonic and adult globin genes during mammalian ontogeny may be considerably broader than presently believed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boussios, T -- Bertles, J F -- Clegg, J B -- AM 27116/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183746" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Cricetinae ; Fetal Hemoglobin/genetics ; Gene Expression Regulation ; Globins/*genetics ; Liver/*physiology ; Spleen/physiology ; Yolk Sac/*physiology
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    Identification of a protein that purifies with the scrapie prion (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: Purification of prions from scrapie-infected hamster brain yielded a protein that was not found in a similar fraction from uninfected brain. The protein migrated with an apparent molecular size of 27,000 to 30,000 daltons in sodium dodecyl sulfate polyacrylamide gels. The resistance of this protein to digestion by proteinase K distinguished it from proteins of similar molecular weight found in normal hamster brain. Initial results suggest that the amount of this protein correlates with the titer of the agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bolton, D C -- McKinley, M P -- Prusiner, S B -- AG02132/AG/NIA NIH HHS/ -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6815801" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*pathology ; Brain Chemistry ; Centrifugation, Density Gradient ; Cricetinae ; Electrophoresis, Polyacrylamide Gel ; Endopeptidase K ; Endopeptidases/metabolism ; Molecular Weight ; Nerve Tissue Proteins/*isolation & purification ; Prions/growth & development ; Scrapie/*pathology ; Sheep ; Virus Activation
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    Coupling of histone and DNA synthesis in the somatic cell cycle (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Delegeane, A M -- Lee, A S -- 2S07RR05356/RR/NCRR NIH HHS/ -- CA27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cricetinae ; DNA/biosynthesis ; *DNA Replication ; Histones/*biosynthesis ; Mutation
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    Events in the evolution of pre-proinsulin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-20
    Description: An extensive computer-assisted analysis of known pre-proinsulin coding sequences has shown correlations that can be interpreted as evidence for an intron-mediated juxtaposition of exons in the evolution of these genes. The evidence includes the discovery that the regions of the pre-proinsulin genes that code for the signal peptide consist of nearly tandem repeating units of nine base pairs. This pattern reappears in the C region of the genes after a large intron that occurs in three of the four genes analyzed. A model is proposed in which primordial insulin was coded for by two separate minigenes arising from a gene duplication, each with identical or nearly identical signal peptide coding regions. The minigenes fused into one transcriptional unit mediated by the large intron, and the signal peptide coding region of one of the putative minigenes evolved into the latter portion of the C peptide coding region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Douthart, R J -- Norris, F H -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):729-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100918" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Biological Evolution ; Computers ; Cricetinae ; Disulfides ; Genes ; Humans ; Insulin ; Models, Genetic ; Proinsulin/*genetics ; Protein Precursors/*genetics ; Rats ; Repetitive Sequences, Nucleic Acid
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    Malnutrition and fertility (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frisch, R E -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1272-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7199206" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*physiopathology ; Female ; Humans ; *Lactation ; *Nutritional Physiological Phenomena ; *Postpartum Period ; Pregnancy
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    Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-12
    Description: The concentration of oxytocin receptors increased in the myometrium of pregnant women and reached maximum levels in early labor. Concentrations of oxytocin receptors were also high in the decidua and reached a maximum at parturition. In vitro, prostaglandin production by the decidua, but not by the myometrium, was increased by the addition of oxytocin. Oxytocin may therefore stimulate uterine contractions by acting both directly on the myometrium and indirectly on decidual prostaglandin production. Oxytocin receptors are probably crucial for the onset of human labor, and the stimulus for the increase in uterine prostaglandins may be oxytocin originating from the fetus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuchs, A R -- Fuchs, F -- Husslein, P -- Soloff, M S -- Fernstrom, M J -- HD8406/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1396-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278592" target="_blank"〉PubMed〈/a〉
    Keywords: Decidua/physiology ; Female ; Humans ; *Labor, Obstetric ; Myometrium/physiology ; Oxytocin/*physiology ; Pregnancy ; Prostaglandins E/biosynthesis ; Prostaglandins F/biosynthesis ; Receptors, Cell Surface/*physiology ; Uterus/*physiology
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Chromosomal assignment of the endogenous proto-oncogene C-abl (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Abelson murine leukemia virus (A-MuLV) is a replication-defective retrovirus that transforms lymphocytes of the B-cell lineage. This virus is a recombinant between the parental Moloney murine leukemia virus and a cellular gene termed C-abl. By analysis of a series of mouse x Chinese hamster hybrid celllines containing various mouse chromosomes, we have mapped the C-abl gene to mouse chromosome 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goff, S P -- D'Eustachio, P -- Ruddle, F H -- Baltimore, D -- CA-14051/CA/NCI NIH HHS/ -- GM-09966/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1317-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293057" target="_blank"〉PubMed〈/a〉
    Keywords: Abelson murine leukemia virus/*genetics ; Animals ; B-Lymphocytes ; Cell Transformation, Viral ; Chromosome Mapping ; Cricetinae ; Cricetulus ; Hybrid Cells/analysis ; Leukemia Virus, Murine/*genetics ; Mice ; *Oncogenes
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    Alcohol and pregnancy (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kline, J -- New York, N.Y. -- Science. 1982 May 7;216(4546):564.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071603" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholic Beverages/*adverse effects ; Female ; Humans ; Pregnancy ; Pregnancy Complications/*chemically induced
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    Estrogen receptors at implantation sites of rat endometrium (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logeat, F -- Sartor, P -- Hai, M T -- Milgrom, E -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1134-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063848" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryo Implantation ; Endometrium/*metabolism ; Female ; Pregnancy ; Rats ; Receptors, Estrogen/*metabolism
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    Neonatal treatment with antiserum to prolactin lowers blood pressure in rats (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: Prolactin administration reportedly increases blood pressure in rats and rabbits. To study the effects of prolactin deficiency on blood pressure, rats were given saline, normal rabbit serum, or rabbit antiserum to rat prolactin on postnatal days 2 to 5. Both males and females given antiserum had significantly lower blood pressure at 14 weeks than rats given saline or normal rabbit serum. Blood pressure differences between females given antiserum and females given saline disappeared during and following pregnancy. The antiserum also lowered the concentration of prolactin in plasma 49 percent in males and decreased the prolactin response to ether stress in both sexes. These results suggest that endogenous prolactin is involved in blood pressure regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mills, D E -- Buckman, M T -- Peake, G T -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):162-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Blood Pressure ; Female ; Immune Sera/pharmacology ; Male ; Pregnancy ; Pregnancy, Animal ; Prolactin/blood/immunology/*physiology ; Rabbits ; Rats ; Rats, Inbred Strains ; Sex Characteristics ; Sodium Chloride/pharmacology
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    Splitting of the circadian rhythm of activity is abolished by unilateral lesions of the suprachiasmatic nuclei (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-26
    Description: The circadian rhythm of activity in vertebrates often splits into two components after continuous exposure to constant light. This observation suggests that at least two circadian pacemakers underlie the activity rhythm. After unilateral ablation of the hypothalamic suprachiasmatic nuclei in hamsters, the splitting phenomenon was eliminated and a single rhythm of activity was established. The period of the new circadian activity rhythm different from the periods of the split rhythm and that preceding the split. These results suggest an interaction between the bilaterally paired suprachiasmatic nuclei in the generation of the circadian rhythm of activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickard, G E -- Turek, F W -- HD-09885/HD/NICHD NIH HHS/ -- HD-12622/HD/NICHD NIH HHS/ -- K04 HD-00249/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1119-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063843" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Circadian Rhythm ; Cricetinae ; Functional Laterality ; Hypothalamus/*physiology ; Motor Activity ; Supraoptic Nucleus/*physiology
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    A monoclonal antibody that reacts with nonallelic enzyme glycoproteins (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-02
    Description: One of six monoclonal antibodies raised against purified human placental alkaline phosphatase cross-reacts with the adult and fetal forms of intestinal alkaline phosphatase. The placental and intestinal enzymes are nonallelic. A new electrophoretic titration procedure was used to assess the relative reactivities of the different enzymes with the antibody. The placental enzyme was the most reactive. However, the adult intestinal enzyme showed greater reactivity than the fetal enzyme. The determinants to which the antibody binds on these three forms of alkaline phosphatase presumably differ in their detailed molecular configurations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gogolin, K J -- Wray, L K -- Slaughter, C A -- Harris, H -- GM07511/GM/NIGMS NIH HHS/ -- GM20138/GM/NIGMS NIH HHS/ -- GM27018/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 2;216(4541):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6175022" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaline Phosphatase/genetics/*immunology ; Alleles ; Antibodies, Monoclonal/*immunology ; Antibody Specificity ; Cross Reactions ; Epitopes ; Female ; Glycoproteins/*immunology ; Humans ; Intestines/enzymology ; Placenta/enzymology ; Pregnancy
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    Oxygen delivery to the brain before and after birth (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-16
    Description: We studied the relationship between cerebral oxygen consumption and cerebral oxygen delivery (cerebral blood flow x arterial oxygen content) in fetal, newborn, and adult sheep, Relative to the amount of oxygen consumed, cerebral oxygen delivery in the fetus exceeds that in the lamb and adult by 70 percent. This may represent a protective advantage for the fetus or simply a necessary adaptation to the low arterial oxygen pressure in the intrauterine environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, M D Jr -- Rosenberg, A A -- Simmons, M A -- Molteni, R A -- Koehler, R C -- Traystman, R J -- HD-13830/HD/NICHD NIH HHS/ -- HL-10342/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):324-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6801768" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*physiology ; Brain/*blood supply/*embryology ; Carbon Dioxide/blood ; Female ; Oxygen/*blood ; Oxygen Consumption ; Pregnancy ; Sheep
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    FDA to reexamine bendectin data (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):335.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046049" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*epidemiology ; Animals ; Clinical Trials as Topic ; Dicyclomine ; Doxylamine/*adverse effects ; Drug Combinations/adverse effects ; Female ; Heart Septal Defects, Ventricular/chemically induced ; Hernia, Diaphragmatic/chemically induced ; Humans ; Macaca ; Pregnancy ; Pyridines/*adverse effects ; Pyridoxine/*adverse effects ; Rats ; United States ; United States Food and Drug Administration
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    Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: An influenza A reassortant virus that contained the hemagglutinin and neuraminidase genes of a virulent human virus, A/Udorn/72 (H3N2), and the six other influenza A virus genome segments from an avirulent avian virus, A/Mallard/New York/6750/78 (H2N2), was evaluated for its level of replication is squirrel monkeys and hamsters. In monkeys, the reassortant virus was as attenuated and as restricted in its level of replication in the upper and lower respiratory tract as its avian influenza virus parent. Nonetheless, infection with the reassortant induced significant resistant to challenge with virulent human influenza virus. In hamsters, the reassortant virus replicated to a level intermediate between that of its parents. These findings suggest that the nonsurface antigen genes of the avian parental virus are the primary determinants of restriction of replication of the reassortant virus in monkeys. Attenuation of the reassortant virus for primates is achieved by inefficient functioning of the avian influenza genes in primate cells, while antigenic specificity of the human influenza virus is provided by the neuraminidase and hemagglutinin genes derived from the human virus. This approach could lead to the development of a live influenza A virus vaccine that is attenuated for man if the avian influenza genes are similarly restricted in human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, B R -- Sly, D L -- Tierney, E L -- Hosier, N T -- Massicot, J G -- London, W T -- Chanock, R M -- Webster, R G -- Hinshaw, V S -- CA 21765/CA/NCI NIH HHS/ -- N01-AI-02649/AI/NIAID NIH HHS/ -- N01-NS-7-2375/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Surface/genetics ; Cricetinae ; Epitopes/genetics/immunology ; Hemagglutinins/genetics/immunology ; Influenza A virus/*genetics ; Influenza Vaccines/*immunology ; Neuraminidase/genetics/immunology ; Saimiri ; Vaccines, Attenuated/immunology
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    Potassium iodide policy (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1982 Oct 1;218(4567):6, 8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123219" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Female ; Humans ; Iodine Radioisotopes/*adverse effects ; Nuclear Reactors ; Potassium Iodide/*therapeutic use ; Pregnancy ; Thyroid Gland/metabolism ; United States ; United States Food and Drug Administration
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    Gestational zinc deprivation in mice: persistence of immunodeficiency for three generations (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Pregnant Swiss Webster mice were fed a diet moderately deficient in zinc from day 7 of gestation until parturition. Offspring of these mice showed depressed immune function through 6 months of age. In addition, the second and third filial generations, all of which were fed only the normal control diet, continued to manifest reduced immunocompetence, although not to the same degree as in the first generation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beach, R S -- Gershwin, M E -- Hurley, L S -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):469-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123244" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Formation ; Female ; Immune Tolerance ; Immunoglobulin M/analysis ; Immunologic Deficiency Syndromes/*embryology ; Mice ; Pregnancy ; Time Factors ; Zinc/*deficiency
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    Legal abortion: the public health record (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-26
    Description: The increasing availability and utilization of legal abortion in the United States has several important effects on public health in the 1970's. It reduced deaths and surgical complications among women of childbearing age; it made possible the development of safer surgical procedures for pregnancy termination; and it increased the provision of low-cost outpatient gynecologic services. There is some concern about potential adverse outcomes in future desired pregnancies and possibly higher risks of breast cancer in certain women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cates, W Jr -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1586-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071579" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Legal/adverse effects/methods/*utilization ; Breast Neoplasms/etiology ; Costs and Cost Analysis ; Ethics, Medical ; Female ; Humans ; Pregnancy ; Professional Misconduct ; Risk Assessment ; United States ; the increased availability and utilization of abortion. The legalization of ; abortion has led to a decrease in deaths and surgical complications among women ; of childbearing age, the development of safer procedures for pregnancy ; termination, and the provision of low-cost outpatient services. Adverse outcomes ; in future pregnancies and an increase in breast cancer risk are two of the ; possible negative results of the increased abortion rate. Three graphs and a ; statistical table illustrate the article.
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  • 68
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    Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-19
    Description: Pregnant rats underfed in the first 2 weeks of gestation had offspring with normal body weight at birth and weaning. However, starting at about 5 weeks of age the male offspring became hyperphagic and gained more weight than the controls. The female offspring did not overeat and did not become obese. Both male and female progeny showed increased fat cell size as adults. In males the epididymal and retroperitoneal fat pads were significantly enlarged nd adipocytes in these pads were hypertrophied. In females and fat pads were not enlarged, but adipocytes in the parametrial pads were hypertrophied.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, A P -- Friedman, M I -- AM-20022/AM/NIADDK NIH HHS/ -- RR 07048/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1518-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063860" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/*cytology ; Animals ; Female ; Gestational Age ; Nutrition Disorders/*complications ; Obesity/*etiology ; Pregnancy ; *Pregnancy, Animal ; Rats ; Sex Factors
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  • 69
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    Prenatal exposure to the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether destroys the rodent Harderian gland (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: Exposure of mice to the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether during gestation produces abnormalities that are not readily apparent at birth but become obvious as the pups mature. By 2 weeks after birth there are severe intraorbital defects resulting from destruction of the Harderian glands behind the eyes. This effect is noticeable only postnatally because the Harderian gland does not grow or function until after birth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, L E Jr -- Kavlock, R J -- Chernoff, N -- Ferrell, J -- McLamb, J -- Ostby, J -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):293-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053576" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*pathology ; Animals ; Female ; Harderian Gland/abnormalities/*drug effects ; Lacrimal Apparatus/*drug effects ; Male ; Mice ; Phenyl Ethers/*toxicity ; Pregnancy ; Rats ; Thyroxine/physiology
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    Prenatal exposure to phenobarbital permanently decreases testosterone and causes reproductive dysfunction (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: Exposure of rats to phenobarbital during late prenatal development decreased the concentration of testosterone in plasma and the brain during the late fetal, early postnatal, pubertal, and adult periods, By decreasing the production of testosterone in the brain during the period of sexual differentiation, phenobarbital may lead to sexual dysfunction in later life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, C -- Yaffe, S J -- Shapiro, B H -- GM-26222/GM/NIGMS NIH HHS/ -- HD -10063/HD/NICHD NIH HHS/ -- T-32GM07514/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 May 7;216(4546):640-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7200262" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/embryology ; Female ; Infertility, Male/*chemically induced ; Male ; Phenobarbital/*pharmacology ; Pregnancy ; Pregnancy, Animal/drug effects ; Rats ; Sex Differentiation/*drug effects ; Testis/metabolism ; Testosterone/*metabolism
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    Transmission of Oropouche virus from man to hamster by the midge Culicoides paraensis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: Oropouche virus (arbovirus family Bunyaviridae, Simbu serological group) was experimentally transmitted from man to hamster by the bite of the midge Culicoides paraensis. Infection rates and transmission rates were determined after the midge had engorged on patients with viremia. The threshold titer necessary to enable infection or transmission by the midges was approximately 5.3 log10 of the median lethal dose of the virus in suckling mice per milliliter of blood. Transmission was achieved 6 to 12 days after C. paraensis had taken the infective blood meal. This represents conclusive evidence of transmission of an arbovirus of public health importance to man by a member of the Ceratopogonidae family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pinheiro, F P -- Travassos da Rosa, A P -- Gomes, M L -- LeDuc, J W -- Hoch, A L -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1251-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6800036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bunyaviridae/*physiology ; Bunyaviridae Infections/*transmission ; Ceratopogonidae/*microbiology ; Cricetinae ; Disease Models, Animal ; Humans ; Insect Vectors/*microbiology ; Simbu virus/*physiology
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    Controlled photoperiodic environments for food animals (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, H A -- Ringer, R K -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1381-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7201162" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Husbandry/*methods ; Animals ; Animals, Domestic/*physiology ; Breeding ; Cattle ; Chickens/physiology ; Eggs ; Estrus/radiation effects ; Female ; Gonadal Steroid Hormones/*radiation effects ; *Light ; Male ; Milk ; Ovulation/radiation effects ; *Periodicity ; Pregnancy ; Reproduction/radiation effects
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  • 73
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    Magnetometry of ingested particles in pulmonary macrophages (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-04
    Description: Sensitive magnetometry has shown that, after inhalation of airborne magnetic dust by humans or animals, particles retained within the lungs rotate. A number of mechanisms for this rotation have been proposed, including motions of breathing, particle thermal energy, cardiac pulsations, surface fluid flows, and macrophage cytoplasmic movements. In this study the cellular mechanism was examined by magnetometry and videomicroscopy of pulmonary macrophages removed from hamster lungs 1 day after inhalation of a maghemite (gamma-Fe2O3) aerosol. The field remaining after magnetization was measured in adherent cells and was found to decay rapidly to 30 percent of its initial magnitude within 12 minutes. The remanent-field decay rate was slowed by inhibitors of cytoplasmic motion. Videomicroscopy of pulmonary macrophages with phagocytized gamma-Fe2O3 showed amoeboid motions that rotated the particles away from their original direction of magnetization. The results confirm that macrophage cytoplasmic movement is a primary cause of remanent-field decay in lungs and that magnetometry can be used to quantify intracellular contractile activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valberg, P A -- ES-00002/ES/NIEHS NIH HHS/ -- HL-29175/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 May 4;224(4648):513-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710153" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4-Dinitrophenol ; Aerosols ; Animals ; Cold Temperature ; Cricetinae ; Cytochalasin D ; Cytochalasins/pharmacology ; Cytoplasm/*physiology ; Dinitrophenols/pharmacology ; *Ferric Compounds ; *Iron ; Lysosomes/analysis ; Macrophages/*physiology/ultrastructure ; *Magnetics ; Microscopy ; Motion Pictures as Topic ; Movement/drug effects ; *Phagocytosis ; Pulmonary Alveoli/cytology
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    Suppression of prolactin in pigs by Escherichia coli endotoxin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: An endotoxin produced by Escherichia coli caused a decrease in prolactin concentrations in the plasma of sows when given at low dosages 2 days postpartum. Five to tenfold increases occurred in the plasma cortisol concentrations. Piglet growth, used as an indicator of milk secretion by the sows, was significantly depressed after the endotoxin administration. Some cases of lactation failure in the periparturient sow may thus be due to endotoxins suppressing prolactin concentrations. This appears to be the first report of a bacterial endotoxin having an effect on prolactin in any species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, B B -- Wagner, W C -- New York, N.Y. -- Science. 1984 May 11;224(4649):605-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6369541" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Endotoxins/*pharmacology ; *Escherichia coli ; Female ; Lactation/drug effects ; Lactation Disorders/etiology ; Pregnancy ; Prolactin/*blood ; Swine/*physiology
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  • 75
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    Modulation of the metastatic activity of melanoma cells by laminin and fibronectin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-23
    Description: Metastatic mouse melanoma cells have a high affinity for the basement membrane and the ability to degrade it; these properties may allow tumor cells to invade the membrane and disseminate. In this study it was found that the metastatic potential of mouse melanoma cells varied when the cells were exposed in culture to fibronectin or laminin. After removal of fibronectin or exposure to laminin, the cells had an increased affinity for basement membrane collagen, were more invasive of basement membranes in vitro, and produced more lung colonies in vivo. These changes are correlated with and may be due to an increase in the laminin-binding capacity of the tumor cell surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terranova, V P -- Williams, J E -- Liotta, L A -- Martin, G R -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):982-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505678" target="_blank"〉PubMed〈/a〉
    Keywords: Amnion/physiology ; Animals ; Cell Division/drug effects ; Cell Line ; Female ; Fibronectins/*pharmacology ; Humans ; Immune Sera ; Kinetics ; Laminin/*pharmacology ; Melanoma/*pathology ; Mice ; Neoplasm Metastasis/*pathology ; Pregnancy
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    Intestinal uptake and metabolism of auranofin, a new oral gold-based antiarthritis drug (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-27
    Description: Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-(triethy lphosphine)- gold(I), an experimental antiarthritis pharmaceutical, metabolized in contact with hamster or rat gut wall to yield the deacetylated form of the drug. This product, 1-thio-beta-D-glucopyranosato-S-(triethylphosphine)gold(I), passed through hamster or rat intestinal wall in an everted gut experiment. The metabolite was separated by high-performance liquid chromatography and characterized by retention time, chemical reactivity to yield a known product, and comparison to a synthetic sample of the metabolite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tepperman, K -- Finer, R -- Donovan, S -- Elder, R C -- Doi, J -- Ratliff, D -- Ng, K -- New York, N.Y. -- Science. 1984 Jul 27;225(4660):430-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6429854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Inflammatory Agents/*metabolism ; Auranofin ; Aurothioglucose/*analogs & derivatives/metabolism ; Chromatography, High Pressure Liquid ; Cricetinae ; Gold/*analogs & derivatives ; *Intestinal Absorption ; Mesocricetus ; Rats ; Rats, Inbred Strains
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    Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-30
    Description: From an acute B-cell leukemia cell line, a DNA probe was obtained that was specific for chromosome 18 and flanked the heavy chain joining region of the immunoglobulin heavy chain locus on chromosome 14. This probe detected rearrangement of the homologous DNA segment in the leukemic cells and in follicular lymphoma cells with the t(14:18) chromosome translocation but not in other neoplastic or normal B or T cells. The probe appears to identify bcl-2, a gene locus on chromosome 18 (band q21) that is unrelated to known oncogenes and may be important in the pathogenesis of B-cell neoplasms with this translocation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsujimoto, Y -- Finger, L R -- Yunis, J -- Nowell, P C -- Croce, C M -- CA15822/CA/NCI NIH HHS/ -- CA16685/CA/NCI NIH HHS/ -- CA20034/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1097-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6093263" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*cytology ; Chromosome Banding ; *Chromosomes, Human, 13-15 ; *Chromosomes, Human, 16-18 ; *Cloning, Molecular ; Cricetinae ; Cricetulus ; DNA Restriction Enzymes ; DNA, Recombinant/analysis ; Humans ; Hybrid Cells/cytology ; Karyotyping ; Leukemia/*genetics ; Mice ; *Translocation, Genetic
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    Enhanced arboviral transmission by mosquitoes that concurrently ingested microfilariae (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: Infection, dissemination, and transmission of an arbovirus in mosquitoes are enhanced by concurrent ingestion of microfilariae. Ingestion of Rift Valley fever virus alone infected only 64 percent of female Aedes taeniorhynchus. Of these, only 5 percent of refeeding mosquitoes actually transmitted virus. In contrast, ingestion of the same amount of virus from concurrently microfilaremic (Brugia malayi) gerbils resulted in 88 percent infection and 31 percent transmission. Enhanced transmission of virus may be attributed to increased transit of virus across the midgut wall. Endemic filariasis may promote arbovirus transmission in nature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Turell, M J -- Rossignol, P A -- Spielman, A -- Rossi, C A -- Bailey, C L -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1039-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474165" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/*microbiology/parasitology ; Animals ; *Brugia ; *Bunyaviridae ; Cricetinae ; Digestive System/microbiology/parasitology ; Female ; *Filarioidea ; Gerbillinae ; Insect Vectors/*microbiology/parasitology ; Microfilaria ; Rift Valley Fever/*transmission ; *Rift Valley fever virus
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    Chromosomal location of human metallothionein genes: implications for Menkes' disease (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: Human metallothioneins are encoded by a complex multigene family. The chromosomal location of these genes has been determined by gel transfer hybridization analysis of the DNA from human-rodent cell hybrids. Chromosome 16 contains a cluster of metallothionein sequences, including two functional metallothionein I genes and a functional metallothionein II gene. The remaining sequences, including a processed pseudogene, are dispersed to at least four other autosomes. The absence of metallothionein sequences from the X chromosome indicates that Menkes' disease, an X-linked disorder of copper metabolism, affects metallothionein expression by a trans-acting mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, C J -- Hamer, D H -- McBride, O W -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1104-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Diseases, Metabolic/*genetics ; *Chromosome Mapping ; Chromosomes, Human, 16-18 ; Copper/metabolism ; Cricetinae ; Cricetulus ; Humans ; Hybrid Cells ; Menkes Kinky Hair Syndrome/*genetics ; Metallothionein/*genetics ; Mice
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    Virus like sensitivity of the scrapie agent to heat inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-10
    Description: The resistance of the infectious agent of scrapie disease to sterilization at 100 degrees or 121 degrees C is reputed to be inconsistent with the structure of conventional viruses. However, in kinetic studies the majority of hamster scrapie strain 263K infectivity was (like that of previously characterized viruses) rapidly inactivated at temperatures of 100 degrees C or greater. Small resistant subpopulations remained. Similar heat-resistant subpopulations were observed at 60 degrees C for phage lambda but only in the presence of brain homogenate. Brain homogenate may also confer stability to small subfractions of scrapie infectivity. Such refractory subpopulations cannot be used to make structural inferences that are properly obtained from the behavior of the majority population as revealed in the initial inactivation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rohwer, R G -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):600-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6420887" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/microbiology ; Cricetinae ; *Hot Temperature ; Kinetics ; Prions/*growth & development ; Species Specificity ; Sterilization/methods
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    Genetic screening: marvel or menace? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-13
    Description: Genetic screening is a systematic search in the population for persons of certain genotypes. The usual purpose is to detect persons who themselves or whose offspring are at risk for genetic diseases or genetically determined susceptibilities to environmental agents. Is genetic screening a marvel about to free us from the scourge of genetic disease or a menace about to invade our privacy and determine who may reproduce? There are three different types of genetic screening. Newborn screening identifies serious genetic disease at birth, permitting prompt treatment to prevent mental and physical retardation. Fetal screening and prenatal diagnosis identify genetic disease in the fetus permitting selective termination of pregnancy and the opportunity to have children free of defects detectable in utero. Carrier screening identifies individuals heterozygous for a gene for a serious recessive disease who may be at risk for affected offspring. The challenge to society is to provide (by way of cost-effective programs) expert services, including genetic counseling and follow-up, to all who may benefit, to ensure confidentiality and freedom of choice, and to avoid misunderstanding and stigmatization. It is recommended that the objective of screening programs should be to maximize the options available to families at risk rather than to reduce the incidence of genetic diseases. Whenever possible, the providers of these services should be the providers of primary health care. Urgently needed are a greater awareness of avoidable genetic diseases on the part of primary care providers and efforts to familiarize the public with the basic concepts of human genetics through the public school system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowley, P T -- New York, N.Y. -- Science. 1984 Jul 13;225(4658):138-44.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729472" target="_blank"〉PubMed〈/a〉
    Keywords: Amniocentesis ; Disclosure ; Ethics, Medical ; Female ; *Genetic Diseases, Inborn ; *Genetic Testing ; Heterozygote ; Heterozygote Detection ; Humans ; Infant, Newborn ; Information Dissemination ; Insemination, Artificial ; Mandatory Programs ; Metabolism, Inborn Errors/genetics ; Occupational Medicine ; Personal Autonomy ; Phenylketonurias/genetics ; Pregnancy ; Prenatal Diagnosis ; *Risk Assessment ; Spermatozoa ; Tay-Sachs Disease/genetics ; Voluntary Programs ; fetal, and carrier, Rowley describes the development and current status of each, ; as well as the ethical, legal, psychological, and social issues involved. He ; briefly considers the special cases of genetic screening of industrial employees ; and of semen donors. He recommends that the goal of screening programs should be ; to maximize the options available to families at risk rather than to reduce the ; incidence of genetic disease. To accomplish this goal, he urges public and ; professional education on human genetics, research on the best delivery ; mechanisms for current technologies, and the clarification and coordination of ; the roles of health care providers, voluntary organizations, and government ; agencies.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 82
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    Transmammary infection of newborn by larval trematodes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: Newborn cats and mice became infected with Alaria marcianae if they nursed from females that had been experimentally infected with the parasite. All lactating females showed mesocercarial stages in their mammary glands. This may be the first trematode found to undergo transmission through the mammary glands under experimental conditions. Similarities in the behavior of mesocercariae in humans and in the mouse suggest that an infected human female might infect her infant if she elected to nurse it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shoop, W L -- Corkum, K C -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1082-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Cats ; Feces/parasitology ; Female ; *Lactation ; Mammary Glands, Animal/*parasitology ; Maternal-Fetal Exchange ; Mice ; Pregnancy ; Trematode Infections/congenital/parasitology/*transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    Toxicant-disease-environment interactions associated with suppression of immune system, growth, and reproduction (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: The effects of marginal malnourishment , infections, and environmental chemicals on growth and reproductive success in Swiss-Webster white mice and wild deer mice were studied with fractional factorial designs. Interaction effects were discovered. For example, malnourished mice were more sensitive to virus exposure and environmental chemicals (a plant growth regulator or polychlorinated biphenyls). Since several commercial plant growth regulators also appear to suppress the immune system, these results cast doubt on the adequacy of current toxicity testing procedures in which factors are studied individually and not in combination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, W P -- Hinsdill, R -- Fairbrother, A -- Olson, L J -- Jaeger, J -- Yuill, T -- Bisgaard, S -- Hunter, W G -- Nolan, K -- 5-T32-ES07015/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):1014-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6426058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Wild ; Chlormequat/adverse effects ; Cyclophosphamide/adverse effects ; Encephalomyelitis, Venezuelan Equine/physiopathology ; Environmental Exposure ; Female ; Food Supply ; Growth/*drug effects ; Humans ; Immunity/*drug effects ; Mice ; Nutrition Disorders/physiopathology ; Peromyscus ; Polychlorinated Biphenyls/adverse effects ; Pregnancy ; Reproduction/*drug effects ; Water Supply
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP) (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: 5-Amino-4-imidazolecarboxamide riboside triphosphate (ZTP) is thought to play a regulatory role in cellular metabolism. Unlike other nucleoside triphosphates, ZTP is synthesized in a one-step reaction in which the pyrophosphate group of 5-phosphoribosyl-l-pyrophosphate is transferred to the riboside monophosphate (ZMP) in a reaction catalyzed by 5-phosphoribosyl-l-pyrophosphate synthetase; reversal of this reaction leads to dephosphorylation of ZTP to ZMP. This unusual route of synthesis (and catabolism) of ZTP may be important in defining its metabolic effects in the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabina, R L -- Holmes, E W -- Becker, M A -- AM12413/AM/NIADDK NIH HHS/ -- AM28554/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6199843" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Aminoimidazole Carboxamide/analogs & derivatives/*biosynthesis/pharmacology ; Animals ; Cell Line ; Cricetinae ; Imidazoles/*biosynthesis ; Kinetics ; Phosphoribosyl Pyrophosphate/metabolism ; Phosphorylation ; Ribonucleosides/pharmacology ; Ribonucleotides/*biosynthesis ; Ribose-Phosphate Pyrophosphokinase/metabolism ; Substrate Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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