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  • Humans  (613)
  • American Association for the Advancement of Science (AAAS)  (613)
  • 1980-1984  (613)
  • 1983  (343)
  • 1982  (270)
Collection
Publisher
  • American Association for the Advancement of Science (AAAS)  (613)
Years
  • 1980-1984  (613)
Year
  • 1
    Publication Date: 1982-10-08
    Description: Sounds recorded in Dallas at the time of the assassination of John F. Kennedy were analyzed by two research groups, whose reports formed the basis for the opinion that two gunmen fired at President Kennedy. These reports and the acoustic evidence have been studied by the Committee on Ballistic Acoustics, and further acoustic analyses, including sound spectrograms, have been performed. The committee finds that the acoustic data do not support a conclusion that a second gunman was involved in the assassination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1982 Oct 8;218(4568):127-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6750789" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustics ; *Famous Persons ; *Forensic Medicine ; History, 20th Century ; Humans ; Male ; Texas ; *Wounds, Gunshot
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1982 Aug 27;217(4562):776-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100923" target="_blank"〉PubMed〈/a〉
    Keywords: Asia, Southeastern ; *Biological Warfare ; Humans ; *Mycotoxins
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-03-19
    Description: The amount of red chromatic valence of the red-green opponent colors channel of the human visual system has been reported to be greatly reduced in short wavelengths when the hue-matching method is used to measure red valence instead of the more typical cancellation method. Receptive fields with a silent surround were postulated to explain the reduction, and it was emphasized that the reduced valence curve represented the true chromatic valence curve of the visual system. In the present studies the previous results are interpreted to be a direct consequence of the method and the particular matching stimuli used. It is shown that the reduction can be explained by the existing color-matching data without appealing to the silent surround hypothesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ayama, M -- Ikeda, M -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1538-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063866" target="_blank"〉PubMed〈/a〉
    Keywords: Color Perception/*physiology ; Humans ; Vision, Ocular/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benveniste, R E -- Todaro, G J -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1202.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112123" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Physiological Phenomena ; Eukaryotic Cells/*physiology ; Humans ; *Recombination, Genetic ; Retroviridae/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-08-20
    Description: Mice will replace the tip of a foretoe when it is amputated distal to the last interphalangeal joint. Amputation of the digit more proximal to the joint does not result in regrowth of the foretoe. Though this growth shares certain similarities with the epimorphic regeneration of amphibian limbs, the two processes are not the same. The regrowth reported here in mice is probably similar to the scattered clinical reports of fingertips regeneration in children, and presents a model system with which to explore the controls of wound healing and tissue reconstruction in mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borgens, R B -- CA 20920/CA/NCI NIH HHS/ -- NS 18456/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):747-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100922" target="_blank"〉PubMed〈/a〉
    Keywords: Amputation ; Animals ; Child ; Humans ; Mice ; Mice, Inbred C3H ; *Regeneration ; Toe Joint ; Toes/anatomy & histology/*physiology ; Wound Healing
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bock, F G -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):197.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053573" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Risk ; *Smoking ; *Tobacco Smoke Pollution
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, William J -- New York, N.Y. -- Science. 1982 Jun 4;216(4550):1081.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643749" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; *Financial Support ; *Financing, Government ; *Fraud ; *Government ; Government Regulation ; *Human Experimentation ; Humans ; Neoplasms ; Pharmaceutical Preparations ; Public Policy ; *Research Personnel ; *Scientific Misconduct ; Social Control, Formal ; Social Responsibility ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, William J -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):391.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643742" target="_blank"〉PubMed〈/a〉
    Keywords: *Cloning, Organism ; *Fraud ; History, 20th Century ; Humans ; Jurisprudence ; Literature
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1982 Jul 16;217(4556):198, 200.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089554" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Radioactive Fallout ; *Radioactive Pollutants ; *Rural Population ; Ussr
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cartmill, M -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1145.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6983135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Humans ; Primates/*genetics ; T-Lymphocytes/*immunology
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-11-12
    Description: Three experiments on tachistoscopic perception of visual stimuli demonstrate that the visual system is sensitive to global topological properties. The results indicate that extraction of global topological properties is a basic factor in perceptual organization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, L -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):699-700.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134969" target="_blank"〉PubMed〈/a〉
    Keywords: *Form Perception ; Humans ; *Visual Perception
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-05-07
    Description: Electrophoretic study of phosphoglucomutase (PGM) in human milk revealed different patterns that can be explained by the existence of a locus distinct from the common PGM1, PGM2, and PGM3. One hundred and forty samples were tested and the results showed four different alleles of PGM4 whose frequencies were under Hardy-Weinberg equilibrium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantu, J M -- Ibarra, B -- New York, N.Y. -- Science. 1982 May 7;216(4546):639-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6461922" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Erythrocytes/enzymology ; Female ; Gene Expression Regulation ; Humans ; Isoenzymes/genetics ; Milk, Human/*enzymology ; Phenotype ; Phosphoglucomutase/*genetics
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowan, M D -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):884.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Humans ; Occupational Diseases/chemically induced ; United States ; *United States Occupational Safety and Health Administration
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  • 14
    Publication Date: 1982-03-05
    Description: The relative amounts of autoantibodies against defined nucleosomal proteins present in serums from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed connective tissue disease (MCTD) have been examined by an enzyme-linked immunoassay. Autoantibodies to nucleosomal proteins were detected in 45 percent of the patients with SLE, 18 percent of the MCTD patients, and none of the RA patients. The results suggest that, in SLE, antibodies are formed against a subset of nucleosomes which contain protein HMG-17.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bustin, M -- Reisch, J -- Einck, L -- Klippel, J H -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1245-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6460317" target="_blank"〉PubMed〈/a〉
    Keywords: Arthritis, Rheumatoid/immunology ; Autoimmune Diseases/*immunology ; Chromosomal Proteins, Non-Histone/*immunology ; High Mobility Group Proteins ; Humans ; Lupus Erythematosus, Systemic/immunology ; Mixed Connective Tissue Disease/immunology ; Nucleosomes/*immunology
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-10-01
    Description: Cultural phenomena may show considerable stability over time and space. Transmission mechanisms responsible for their maintenance are worthy of theoretical and empirical inquiry; they are complex and each possible pathway has different effects on evolutionary stability of traits, as can be shown theoretically. A survey designed to evaluate the importance of some components of cultural transmission on a variety of traits showed that religion and politics are mostly determined in the family, a mode of transmission which guarantees high evolutionary stability and maintenance of high variation between and within groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cavalli-Sforza, L L -- Feldman, M W -- Chen, K H -- Dornbusch, S M -- 10452/PHS HHS/ -- 20467/PHS HHS/ -- 20816/PHS HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):19-27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123211" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude ; Child ; Cultural Characteristics ; *Culture ; Family ; Female ; Humans ; *Interpersonal Relations ; Male ; Marriage ; Models, Psychological ; *Parent-Child Relations
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-10-01
    Description: Mouse embryos were grown successfully in vitro from the blastocyst stage to the limb bud stage. Mouse blastocysts grown in vitro for 10 days showed blood circulation in the yilk sac, forelimb buds, and the primordia of liver, pancreas, and lungs. These characteristics are indicative of a developmental stage equivalent to one-half of the total gestation period in utero. Improvements in culture conditions from days 7 to 9 have made it feasible to culture mouse blastocysts beyond the early somite stage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, L T -- Hsu, Y C -- AM 19535/AM/NIADDK NIH HHS/ -- AM 28550/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123220" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/*physiology ; Cell Differentiation ; Culture Media ; Culture Techniques ; Embryo, Mammalian/*physiology ; Female ; Fetal Blood ; Humans ; Mice ; Pregnancy ; Yolk Sac/physiology
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  • 17
    Publication Date: 1982-11-05
    Description: Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with T-cell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and are found in adults with an acute malignancy of mature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A T-cell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I(CR), HTLV-I(MB), and HTLV-II(Mo)].〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalyanaraman, V S -- Sarngadharan, M G -- Robert-Guroff, M -- Miyoshi, I -- Golde, D -- Gallo, R C -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):571-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6981847" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/analysis ; Humans ; Leukemia, Hairy Cell/*microbiology ; Retroviridae/immunology/*isolation & purification ; T-Lymphocytes/*immunology/microbiology
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  • 18
    Publication Date: 1982-02-19
    Description: A human B cell line producing a monoclonal antibody to an antigenic determinant of acetylcholine receptors was established by cloning B cells that had been transformed in vitro by Epstein-Barr virus. The B cells were obtained from the thymus of a patient with myasthenia gravis. The antibody produced by the cell line precipitated acetylcholine receptors from denervated and innervated rat muscle and from human muscle, but did not show detectable response to the acetylcholine receptors from the electric organs of Narke japonica. The monoclonal antibody showed identical binding patterns in innervated and denervated rat muscles. Passive transfer of the monoclonal antibody into rats induced moderate muscle weakness and electromyographic changes characteristic of myasthenia gravis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kamo, I -- Furukawa, S -- Tada, A -- Mano, Y -- Iwasaki, Y -- Furuse, T -- Ito, N -- Hayashi, K -- Satoyoshi, E -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):995-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297000" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies, Monoclonal ; B-Lymphocytes/immunology ; *Cell Line ; Cell Transformation, Viral ; Herpesvirus 4, Human ; Humans ; Muscles/immunology/innervation ; Myasthenia Gravis/immunology ; Rats ; Receptors, Cholinergic/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
    Publication Date: 1982-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirsch, I R -- Morton, C C -- Nakahara, K -- Leder, P -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6801764" target="_blank"〉PubMed〈/a〉
    Keywords: B-Lymphocytes/*physiology ; Chromosome Mapping ; Genes ; Humans ; Immunoglobulin Heavy Chains/*genetics ; Leukemia/*genetics ; Recombination, Genetic ; Translocation, Genetic
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1295-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183747" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anemia, Sickle Cell/therapy ; Azacitidine/therapeutic use ; Fetal Hemoglobin/biosynthesis/*genetics ; Hemoglobin, Sickle/biosynthesis ; Humans ; Male ; Thalassemia/therapy
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):31-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123213" target="_blank"〉PubMed〈/a〉
    Keywords: Diuretics/*adverse effects ; Heart Diseases/*drug therapy ; Humans ; National Institutes of Health (U.S.) ; Risk ; United States
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):921-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112105" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Base Sequence ; *Genes ; Humans
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-03-05
    Description: Two structurally distinct populations of basal keratinocytes, nonserrated and serrated, were observed in cynomolgus monkey and human palm epidermis. Anatomical location, fine structural features, and kinetic properties suggest that nonserrated cells represent a stem cell population and that serrated cells help anchor the epidermis to the dermis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavker, R M -- Sun, T T -- AM 25140/AM/NIADDK NIH HHS/ -- EY 00125/EY/NEI NIH HHS/ -- EY 02472/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058342" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Nucleus/metabolism ; Epidermis/*cytology ; Hand ; Humans ; Macaca fascicularis
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lele, R D -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123224" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dogs ; Humans ; Medicine, Ayurvedic ; Plant Extracts/*therapeutic use ; *Plants, Medicinal ; Rabies/*prevention & control
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  • 25
    Publication Date: 1982-05-28
    Description: The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D3 was about 20 percent. Major differences in the formation of lumisterol3, and tachysterol3 from previtamin D3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLaughlin, J A -- Anderson, R R -- Holick, M F -- AM 27334/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):1001-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281884" target="_blank"〉PubMed〈/a〉
    Keywords: Cholecalciferol/*biosynthesis/metabolism ; Dehydrocholesterols/radiation effects ; Ergosterol/metabolism ; Humans ; In Vitro Techniques ; Isomerism ; Photochemistry ; Skin/*metabolism ; Spectrum Analysis ; Structure-Activity Relationship ; Ultraviolet Rays
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1982 May 21;216(4548):840-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079741" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Brain/*anatomy & histology ; Energy Metabolism ; Humans ; Primates/*anatomy & histology
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  • 27
    Publication Date: 1982-02-19
    Description: Human T cell lymphoma leukemia virus (HTLV) is a human retrovirus (RNA tumor virus) that was originally isolated from a few patients with leukemias or lymphomas involving mature T lymphocytes. Here we report that the serum of Japanese patients with adult T cell leukemia, but not the serum of tested normal donors, contains high titers of antibodies to HTLV. These observations, together with data from Japan showing that adult T cell leukemia is endemic in southwest Japan, suggest that HTLV is involved in a subtype of human T cell malignancy, including Japanese adult T cell leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robert-Guroff, M -- Nakao, Y -- Notake, K -- Ito, Y -- Sliski, A -- Gallo, R C -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):975-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6760397" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/*analysis ; Antibody Specificity ; Fluorescent Antibody Technique ; Humans ; Japan ; Leukemia/*immunology ; Radioimmunoassay ; Retroviridae/*immunology ; *T-Lymphocytes
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-05-14
    Description: Specific consistent chromosome translocations are regularly observed in certain human leukemias and lymphomas. For the myeloid leukemias, the constant recombinants are: the long arm of 9 to chromosome 22 in chronic myeloid leukemia, the long arm of 21 to chromosome 8 in acute myeloblastic leukemia, and the long arm of 17 to chromosome 15 in acute promyelocytic leukemia. Three related translocations are seen in Burkitt lymphoma and B cell acute lymphocytic leukemia; in each one, chromosome 8 is involved with chromosome 2, 14, or 22. Analysis of a complex translocation affecting chromosomes 8 and 14 indicates that the translocation of chromosome 8 to chromosome 14 is the critical constant rearrangement. The analysis of the DNA at the translocation sites of these chromosomes, rather than the reciprocal of each translocation, appears to be the most productive focus for initial study. The various immunoglobulin loci are located in chromosomes 2, 14, and 22, the chromosomes regularly involved in translocations in Burkitt lymphoma and B cell acute lymphocytic leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowley, J D -- CA 16910/CA/NCI NIH HHS/ -- CA 19266/CA/NCI NIH HHS/ -- CA 25568/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 May 14;216(4547):749-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079737" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Aberrations ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 16-18 ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Genes ; Humans ; Immunoglobulins/*genetics ; Leukemia/*genetics ; Lymphoma/*genetics ; Translocation, Genetic
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-07-30
    Description: Studies of special population groups, epidemiological surveys, controlled longitudinal studies of humans, and longitudinal studies on the effect of sugar substitutes indicate that frequent or high intake of sugary foods predisposes to dental decay. The relation is not always clear-cut, and most studies have important methodological problems and limitations. Longitudinal measurements of caries increments combined with multiple dietary histories are needed to clarity the association between caries and eating habits. The relative cariogenicity of specific foods can be assessed by a combination of in vitro tests, human in vivo tests, and experimental caries in animals. Human diets, however, vary in food items eaten and the frequency and sequence of eating, and these factors can affect the cariogenicity of a food. Therefore, reported correlations must be interpreted with caution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newbrun, E -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):418-23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7046052" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Cariogenic Agents ; Child ; Child, Preschool ; Dental Caries/epidemiology/*etiology ; *Diet, Cariogenic ; Food Habits ; Food Preferences ; Humans ; Longitudinal Studies ; Sucrose/adverse effects/metabolism ; Sweetening Agents/pharmacology
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  • 30
    Publication Date: 1982-12-24
    Description: The ethyl ester of beta-carboline-3-carboxylic acid has a high affinity for benzodiazepine receptors in the brain. In the rhesus monkey this substance produces an acute behavioral syndrome characterized by dramatic elevations in heart rate, blood pressure, plasma cortisol, and catecholamines. The effects are blocked by benzodiazepines and the specific benzodiazepine receptor antagonist Ro 15-1788. The benzodiazepine receptor may consist of several subsites or functional domains that independently recognize agonist, antagonists, or "active" antagonists such as beta-carboline-3-carboxylic acid ethyl ester. These results suggest that the benzodiazepine receptor is involved in both the affective and physiological manifestations of anxiety, and that the administration of beta-carboxylic acid ethyl ester to monkeys may provide a reliable and reproducible animal model of human anxiety.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ninan, P T -- Insel, T M -- Cohen, R M -- Cook, J M -- Skolnick, P -- Paul, S M -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1332-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293059" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anxiety/*etiology ; Benzodiazepinones ; Blood Pressure/drug effects ; Carbolines/pharmacology ; *Disease Models, Animal ; Epinephrine/pharmacology ; Flumazenil ; Heart Rate/*drug effects ; Humans ; Hydrocortisone/blood ; Macaca mulatta ; Male ; Norepinephrine/pharmacology ; Receptors, Drug/*physiology ; Receptors, GABA-A
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1982 Nov 19;218(4574):771.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134972" target="_blank"〉PubMed〈/a〉
    Keywords: *Alcoholism ; *Behavioral Research ; Fraud ; Humans ; *Research ; United States ; allegations that they fabricated data in a project on treatment of alcoholics. ; Their research, which suggested that some alcoholics can reject abstinence and ; learn to moderate their drinking, was disputed by other researchers. The ; investigating committee did not judge whether alcoholics can indeed become ; moderate drinkers but concluded that the Sobells had carried out the research as ; reported except for one lapse ascribed to carelessness. The procedures of the ; committee, which was appointed by the Addiction Research Foundation where the ; Sobells are now employed, have been questioned by critics.
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R Jeffrey -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):545-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643806" target="_blank"〉PubMed〈/a〉
    Keywords: Coercion ; *Deception ; Federal Government ; Government ; *Hazardous Substances ; Humans ; Information Dissemination ; Information Services ; Judicial Role ; Jurisprudence ; Nevada ; Nuclear Warfare ; *Public Policy ; *Radiation ; *Research Personnel ; *Scientific Misconduct ; Utah ; Atomic Energy Commission officials suppressed data indicating a link between two ; 1953 atomic bomb tests in Nevada and sheep deaths in neighboring Utah, and then ; pressured scientific investigators to concur with the AEC position. In a 1956 ; trial, a federal judge denied compensation to the sheep owners. Evidence of the ; deception came to light in 1979 and 1980 and, on 24 August 1982, the same judge ; ordered a new trial, ruling that several AEC attorneys and scientists had indeed ; misrepresented the facts. His ruling has been appealed by the Department of ; Justice.
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  • 33
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-08-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):808-9, 811.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100924" target="_blank"〉PubMed〈/a〉
    Keywords: *Chemical Industry ; Humans ; *Industrial Waste ; Risk ; United States
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  • 34
    Publication Date: 1982-11-19
    Description: Increment-threshold spectral sensitivity functions were determined during the dominance and suppression phases of binocular rivalry. The shapes of the functions obtained during the dominance phase exhibited three maxima at approximately 440, 530, and 610 nanometers and resembled functions obtained for nonrivalrous control conditions. However, the functions measured during suppression had a single broad peak near 555 nanometers and were adequately described by functions measured with flicker methods during nonrivalrous conditions. The results indicate that binocular rivalry differentially attenuates opponent-color information relative to achromatic information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, E L -- Levi, D M -- Harwerth, R S -- White, J M -- EY01139/EY/NEI NIH HHS/ -- EY01728/EY/NEI NIH HHS/ -- EY03611/EY/NEI NIH HHS/ -- R01 EY001139/EY/NEI NIH HHS/ -- R01 EY003611/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 19;218(4574):802-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134975" target="_blank"〉PubMed〈/a〉
    Keywords: *Color Perception ; Functional Laterality ; Humans ; Ocular Physiological Phenomena ; Sensory Thresholds ; *Vision, Ocular
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  • 35
    Publication Date: 1982-03-05
    Description: Norethisterone (17 alpha-ethynyl-19-nortestosterone) is an effective irreversible inhibitor of estrogen synthetase (aromatase), the enzyme responsible for the conversion of androgens to estrogens, even at a 2 X 10(-6) molar concentration. This irreversible inactivation, which is directed toward the active site of aromatase and requires the cofactor-reduced nicotinamide adenine dinucleotide phosphate, is both time- and concentration-dependent. Ethisterone (17 alpha-ethynyltestosterone), in contrast, is not a suicide inhibitor of aromatase even at concentrations of 10(-4) molar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osawa, Y -- Yarborough, C -- HDO4945/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1249-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058343" target="_blank"〉PubMed〈/a〉
    Keywords: *Aromatase Inhibitors ; Binding Sites/drug effects ; Contraceptives, Oral/*pharmacology ; Estrogens/*biosynthesis ; Female ; Humans ; Kinetics ; Microsomes/enzymology ; Norethindrone/*pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Placenta/enzymology ; Pregnancy
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Marjorie -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):871.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643817" target="_blank"〉PubMed〈/a〉
    Keywords: China ; *Fraud ; Humans ; *Research Personnel ; Science ; *Scientific Misconduct ; similar to those that have been troubling the American scientific community. ; Several articles are cited which report cases of fabrication of data, plagiarism, ; or unfair claims to authorship. A Chinese scientific journal has begun a regular ; column on ethics in science, and researchers have drafted a code of ethics for ; the Peking scientific community.
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  • 37
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):912-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6896767" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Food Contamination ; *Heptachlor ; Humans ; *Milk
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089538" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; *Government Agencies ; Humans ; Neoplasms/chemically induced/*prevention & control ; Risk ; United States
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  • 39
    Publication Date: 1982-07-23
    Description: Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearson, R D -- Manian, A A -- Harcus, J L -- Hall, D -- Hewlett, E L -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):369-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124040" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antipsychotic Agents/*pharmacology/therapeutic use ; Chlorpromazine/pharmacology ; Cricetinae ; Humans ; Leishmania/*drug effects ; Leishmaniasis, Visceral/*drug therapy ; Macrophages/microbiology ; Mesocricetus
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-04-23
    Description: Although several studies of Alzheimer's disease suggest that the frequency of neuritic plaques in the cerebral cortex is correlated with the severity of dementia and with reduction in presynaptic cholinergic markers in the cortex, the relationship between cholinergic cortical innervation and the pathogenesis of plaques is unknown. The hypothesis was tested that the neurites in the plaque consist, in part, of presynaptic cholinergic axons, many of which arise from neurons in the basal forebrain. This hypothesis was tested by analyzing the character and distribution of plaques in monkeys, aged 4 to 31 years, with staining for acetylcholin-esterase and also with Congo red and silver stains. Immature and mature plaques were rich in acetylcholinesterase. As the plaques matured, the amount of amyloid increased, and the number of neurites and the activity of acetylcholinesterase decreased. End-stage amyloid-rich plaques lacked acetylcholinesterase. These observations indicate that changes in cortical cholinergic innervation are an important feature in the pathogenesis and evolution of the neuritic plaque.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Struble, R G -- Cork, L C -- Whitehouse, P J -- Price, D L -- NS 07179/NS/NINDS NIH HHS/ -- NS 10580/NS/NINDS NIH HHS/ -- NS 15721/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):413-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6803359" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholinesterase/*metabolism ; Aging ; Alzheimer Disease/metabolism/*pathology ; Amyloid/*metabolism ; Animals ; Dementia/*pathology ; Disease Models, Animal ; Haplorhini ; Humans ; Nerve Degeneration ; Neurons/metabolism
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-09-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):914-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112104" target="_blank"〉PubMed〈/a〉
    Keywords: Benzene/*adverse effects ; Federal Government ; Government Regulation ; Humans ; *Information Dissemination ; Internationality ; Occupational Diseases/*etiology ; *Professional Misconduct ; Risk ; International Agency for Research on Cancer (IARC) deleted a scientific advisory ; group's estimate of the risk of leukemia in workers exposed to small amounts of ; the chemical. Allegations are reported that the estimate, which would have had ; regulatory implications for U.S. industry, was omitted because the National ; Cancer Institute (NCI), responding to industry complaints about the data, ; cautioned the IARC director to refrain from quantitative risk assessment in its ; NCI-funded monographs.
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-01-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tryon, W W -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):300-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053579" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Age Factors ; Brain/growth & development/*physiopathology ; Child ; Child, Preschool ; Electroencephalography ; Humans ; Infant ; Tremor/*physiopathology
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-05-07
    Description: Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeled diethyldithiocarbamate is formed and the number of enzyme sulfhydryl groups decreases from 34 to 30 during this process. Activity is recovered by-mercaptoethanol but not by glutathione, the physiological reducing agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vallari, R C -- Pietruszko, R -- AA 00186/AA/NIAAA NIH HHS/ -- K0200046/PHS HHS/ -- New York, N.Y. -- Science. 1982 May 7;216(4546):637-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071604" target="_blank"〉PubMed〈/a〉
    Keywords: Aldehyde Dehydrogenase ; Aldehyde Oxidoreductases/*antagonists & inhibitors ; Cytoplasm/enzymology ; Disulfiram/*pharmacology ; Humans ; Isoenzymes/antagonists & inhibitors ; Liver/enzymology ; Oxidation-Reduction ; Sulfhydryl Compounds/antagonists & inhibitors
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  • 44
    Publication Date: 1982-05-21
    Description: By means of enzyme immunoassay techniques to detect the presence of antibody to cytomegalovirus, the cerebrospinal fluid of 178 patients with schizophrenia, 17 patients with bipolar disorders, and 11 other psychiatric patients was compared with that of 79 neurological patients and 41 normal control subjects. The cerebrospinal fluid of 20 of the schizophrenic patients and 3 of the patients with bipolar disorders showed significant increases in immunoglobulin M antibody to cytomegalovirus; no difference was found in patients on or off psychotropic medications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Torrey, E F -- Yolken, R H -- Winfrey, C J -- N01 AI 92616/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 May 21;216(4548):892-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281883" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/analysis ; Bipolar Disorder/immunology/microbiology ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/*complications ; Humans ; Immunoglobulin M/analysis ; Schizophrenia/immunology/*microbiology
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-07-16
    Description: By the close of this century the world may have to feed as many as 2 billion additional people. Most of them will be born in developing countries, especially in marginal lands ill-suited for food production. This article focuses on efforts by the International Agricultural Research Centers to increase food production in the Third World and addresses the social and ecological issues raised by the introduction of high-yielding varieties into fertile Third World lands and describe how varieties are being tailored for introduction into marginal areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plucknett, D L -- Smith, N J -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):215-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089555" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; *Developing Countries ; Ecology ; *Food Supply ; Humans ; *Research
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-10
    Description: Breast-feeding is important to infant nutrition, morbidity, and mortality, and to postpartum amenorrhea (hence to birth intervals). Evidence on breast-feeding patterns in low-income countries from nationally representative World Fertility Surveys and secondary sources shows that in all but a few such countries most children are breast-fed for at least a few months. The limited evidence available on trends seems to indicate a decline in the duration of breast-feeding, but in most of Asia and Africa breast-feeding is almost universal during at least the first 6 months. Earlier weaning is common in Latin America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popkin, B M -- Bilsborrow, R E -- Akin, J S -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1088-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146896" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Asia ; *Breast Feeding ; *Developing Countries ; Female ; Humans ; Rural Population ; South America ; Time Factors ; Urban Population
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  • 47
    Publication Date: 1982-04-23
    Description: A previously undescribed species of human leukocyte, or alpha, interferon is present in the serum of many patients with systemic lupus erythematosus. It was shown to be alpha-interferon by neutralization with specific antiserums, affinity column chromatography, and antiviral activity on bovine cells. However, 23 of 30 interferon samples tested were inactivated by incubation at pH 2, a characteristic of human "immune," or gamma, interferon. Multiple samples of interferon from the same patient had similar biological properties, but samples from different patients were not all identical, suggesting that several variants of this species of human alpha-interferon may exist.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preble, O T -- Black, R J -- Friedman, R M -- Klippel, J H -- Vilcek, J -- R01-AI-07057/AI/NIAID NIH HHS/ -- R01-AI-12948/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):429-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6176024" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Hydrogen-Ion Concentration ; Interferons/*blood/immunology ; Lupus Erythematosus, Systemic/*blood
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-04-09
    Description: Electrical subcutaneous nerve stimulation of radial, median, and saphenous nerves has been shown to produce prolonged analgesia. In a double blind study, such stimulation also suppressed clonus for 3 hours after stimulation ceased in subjects with spasticity. Since the effect is contralateral, each subject was his own control. Because stimulation of the nerve in the wrist suppressed ankle clonus, the mechanism mediating the effect must be centrifugal inhibition. These results suggest that subcutaneous nerve stimulation may also be a tool in the management of spasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, J B -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):203-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063882" target="_blank"〉PubMed〈/a〉
    Keywords: Electric Stimulation ; Functional Laterality ; Humans ; Motor Neurons/physiopathology ; Muscle Spasticity/physiopathology/*therapy ; Peripheral Nerves/physiopathology ; Reflex/physiology ; Spinal Cord/physiopathology
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-06-25
    Description: Umbilical cord blood specimens from 11,837 births between April 1979 and April 1981 have been analyzed for lead by anodic stripping voltammetry. The mean was 6.56 +/- 3.19 (standard deviation) micrograms per deciliter of blood, and the range was 0.0 to 37.0 micrograms per deciliter. The mean decreased annually by 0.77 +/- 0.03 microgram per deciliter, about 11 percent. Lead concentrations were higher in infants born in summer than in infants born in winter (7.17 versus 5.99, probability less than .001). A Fourier model of the data is presented, and possible reasons for the decline are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabinowitz, M B -- Needleman, H L -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1429-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089532" target="_blank"〉PubMed〈/a〉
    Keywords: Boston ; Environmental Exposure ; Fetal Blood/*analysis ; Humans ; Infant, Newborn ; Lead/*blood ; Longitudinal Studies ; Maximum Allowable Concentration ; Seasons
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-01-08
    Description: Contrary to a previous assumption, the center of the expanding pattern of visual flow is not generally useful as an aid in judging the direction of self motion since its direction depends on the direction of gaze. For some visual environments, however, the point of maximum rate of change of magnification in the retinal image coincides with the direction of self motion, independently of the direction of gaze. This visual indicator could be used to judge the direction of self motion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Regan, D -- Beverley, K I -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):194-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053572" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Motion Perception/*physiology ; Orientation/physiology ; Retina/physiology ; Visual Perception/*physiology
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  • 51
    Publication Date: 1982-11-26
    Description: The timing of two event-related potential components was differentially affected by two experimental variables. The earlier component (NA) was affected by degradation of the stimuli and the later component (N2) by the nature of a classification task. The results support the hypothesis that NA and N2 reflect sequential stages of information processing, namely, pattern recognition and stimulus classification.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ritter, W -- Simson, R -- Vaughan, H G Jr -- Macht, M -- HD 10804/HD/NICHD NIH HHS/ -- IF32 AGO-5193/AG/NIA NIH HHS/ -- MH 06723/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):909-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134983" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Adult ; Brain/*physiology ; Brain Mapping ; Cognition/*physiology ; Discrimination (Psychology)/physiology ; Evoked Potentials ; Humans ; Information Theory ; Perception/*physiology ; Time Factors
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  • 52
    Publication Date: 1982-12-24
    Description: Spectral analysis of spontaneous fluctuations in human fetal movement revealed strong oscillations at frequencies between 0.24 and 0.90 cycle per minute, which are much higher than those of the cyclic alternation of quiet and active states in the fetus and neonate. Oscillations at frequencies up to 2.88 cycles per minute were also detected, but they were usually much weaker. The prominent peaks in the fetal movement spectra are in the frequency range of recently reported neonatal motor rhythms, and indicate the existence of a cyclic process controlling spontaneous motor output that oscillates near one cycle per minute and begins to function in utero.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robertson, S S -- Dierker, L J -- Sorokin, Y -- Rosen, M G -- M01RR00210/RR/NCRR NIH HHS/ -- P50HD11089/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1327-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146916" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Fetus/*physiology ; Humans ; *Movement ; Pregnancy ; Pregnancy Trimester, Third ; Spectrum Analysis/methods ; Time Factors
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  • 53
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-06-18
    Description: Neuromagnetic measurements of responses to auditory stimuli consisting of pure tones amplitude-modulated at a low frequency have been used to deduce the location of cortical activity. The evoked field source systematically increased in depth beneath the scalp with increasing frequency of the tone. The tonotopic progression can be described as a logarithmic mapping.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romani, G L -- Williamson, S J -- Kaufman, L -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1339-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079770" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Auditory Cortex/anatomy & histology/*physiology ; Evoked Potentials ; Evoked Potentials, Auditory ; Humans ; Magnetics
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  • 54
    Publication Date: 1982-04-30
    Description: Pleural mesothelioma, lung cancer, pleural calcification and fibrosis, and interstitial parenchymal fibrosis have been observed among inhabitants of several villages in south-central Turkey. Earlier reports have stated that environmental and lung tissue samples from this area contained the fibrous zeolite mineral erionite, and this mineral has generally been assumed to be the agent responsible for these endemic pathological conditions in the absence of asbestos outcroppings and usage. Several different kinds of asbestos minerals in addition to erionite have now been found in environmental samples taken from the villages where these diseases occur. The lung tissues of mesothelioma patients from these villages contain both fibrous zeolites and asbestos minerals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rohl, A N -- Langer, A M -- Moncure, G -- Selikoff, I J -- Fischbein, A -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):518-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071597" target="_blank"〉PubMed〈/a〉
    Keywords: Dust ; Environmental Exposure ; Humans ; Lung Diseases/*chemically induced ; Lung Neoplasms/*chemically induced/epidemiology ; Mesothelioma/*chemically induced/epidemiology ; Turkey
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  • 55
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-09-03
    Description: Increases with aging in subperiosteal dimensions and second moments of area (measures of bending and torsional rigidity) in femoral and tibial cross sections are documented in an archeological sample from the American Southwest. Significant differences between cross-sectional sites and between sexes in the pattern of cortical remodeling with age are also present. These differences appear to be related to variations in the stress or strain levels in different regions of the femur and tibia which result from in vivo mechanical loadings of the lower limb.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruff, C B -- Hayes, W C -- AM00749/AM/NIADDK NIH HHS/ -- AM26740/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):945-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112107" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Aging ; Bone Development ; Female ; Femur/*physiology ; Fractures, Bone/etiology ; Growth ; Humans ; Male ; Middle Aged ; Periosteum/*physiology ; Physical Exertion ; Sex Characteristics ; Stress, Mechanical ; Tibia/*physiology
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  • 56
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: Information is represented in long-term memory as a network of associations among concepts. Information is retrieved by spreading activation from concepts in working memory through the network structure. The time required to retrieve information is a function of the level of activation that it achieves. Fanning of multiple paths from a node dissipates the activation the node sends down any path and increases retrieval time. Fan effects are reduced as subjects overlearn the material or when they can change their task from a recognition judgment to a consistency judgment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J R -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):25-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828877" target="_blank"〉PubMed〈/a〉
    Keywords: Face ; Humans ; *Memory ; Mental Recall ; Pattern Recognition, Visual
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  • 57
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-13
    Description: The existence of low-level filtering of sensory input is a point of debate among cognitive theorists. This present study suggests that filtering by modality exists at levels low enough to modulate the brainstem blink reflex and that it is evident as early as the 16th week of life. During foreground listening or looking conditions, blinks elicited by acoustic or visual probes were larger when probe and foreground modality matched than when they mismatched. "Interesting" foregrounds, by comparison with "dull" ones, intensified the modality-selective effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anthony, B J -- Graham, F K -- HDO1490/HD/NICHD NIH HHS/ -- K3-MH21762/MH/NIMH NIH HHS/ -- MHO1798/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):742-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836312" target="_blank"〉PubMed〈/a〉
    Keywords: Attention/*physiology ; Blinking ; Child Development ; Electromyography ; Hearing/physiology ; Heart Rate ; Humans ; Infant ; *Psychology, Child ; Vision, Ocular/physiology
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  • 58
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: The human parasite Trypanosoma brucei gambiense grew continuously at 37 degrees C in primary cultures of murine bone marrow. Cultured parasites remained virulent for mice. Rapid parasite growth coincided with the appearance of adherent adipocyte-epitheloid cell aggregates that also promoted hematopoiesis. This culture system should permit studies of host cell control of trypanosome proliferation, pathogenic effects of trypanosomes on blood cell development, and the relative trypanocidal and marrow suppressive activities of drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balber, A E -- CA 14049/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836284" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow ; Cells, Cultured ; Culture Media ; Humans ; Mice ; Mice, Inbred BALB C ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei gambiense/*growth & development ; Trypanosomiasis, African/parasitology
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  • 59
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: Blink-startle responses to vibroacoustic stimulation were monitored ultrasonically in human fetuses of known gestational age. Responses were first elicited between 24 and 25 weeks of gestational age and were present consistently after 28 weeks. Defining the developmental sequence for audition provides a foundation for diagnosing deafness and recognizing aberrant responses antenatally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnholz, J C -- Benacerraf, B R -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):516-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623091" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Ear/*embryology ; Female ; Fetus/*physiology ; Gestational Age ; *Hearing ; Humans ; Pregnancy ; Ultrasonography ; Vibration
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  • 60
    Publication Date: 1983-04-15
    Description: Spirochetes believed to be the cause of Lyme disease were isolated from white-footed mice and white-tailed deer, the preferred natural hosts of Ixodes dammini, the tick vector. Evidence suggests that deer act as a reservoir of the disease and provide an overwintering mechanism for both spirochetes and adult ticks. Some tick larvae may acquire the spirochete by transovarial passage and the nymphal stage may transmit the disease to humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosler, E M -- Coleman, J L -- Benach, J L -- Massey, D A -- Hanrahan, J P -- Burgdorfer, W -- Barbour, A G -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836274" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachnid Vectors/microbiology ; Arthritis, Infectious/microbiology/transmission ; Deer/microbiology/parasitology ; Disease Vectors ; Female ; Humans ; Male ; Peromyscus/microbiology/parasitology ; Spirochaetales/*growth & development ; Ticks/*microbiology
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  • 61
    Publication Date: 1982-03-05
    Description: Recent evidence indicates that the nucleus basalis of Meynert, a distinct population of basal forebrain neurons, is a major source of cholinergic innervation of the cerebral cortex. Postmortem studies have previously demonstrated profound reduction in the presynaptic markers for cholinergic neurons in the cortex of patients with Alzheimer's disease and senile dementia of the Alzheimer's type. The results of this study show that neurons of the nucleus basalis of Meynert undergo a profound (greater than 75 percent) and selective degeneration in these patients and provide a pathological substrate of the cholinergic deficiency in their brains. Demonstration of selective degeneration of such neurons represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and, as such, points to a critical subcortical lesion in Alzheimer's patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whitehouse, P J -- Price, D L -- Struble, R G -- Clark, A W -- Coyle, J T -- Delon, M R -- MH 00125/MH/NIMH NIH HHS/ -- MH 26654/MH/NIMH NIH HHS/ -- NS 10580/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058341" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Alzheimer Disease/*pathology/physiopathology ; Basal Ganglia/*pathology ; Dementia/*pathology/physiopathology ; Humans ; Neural Pathways/pathology
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  • 62
    Publication Date: 1982-02-05
    Description: Escherichia coli that has been genetically manipulated by recombinant DNA technology to synthesize human insulin polypeptides (A chain, B chain, or proinsulin) contains prominent cytoplasmic inclusion bodies. The amount of inclusion product within the cells corresponds to the quantity of chimeric protein formed by the bacteria. At peak production, the inclusion bodies may occupy as much as 20 percent of the Escherichia coli cellular volume.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, D C -- Van Frank, R M -- Muth, W L -- Burnett, J P -- New York, N.Y. -- Science. 1982 Feb 5;215(4533):687-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7036343" target="_blank"〉PubMed〈/a〉
    Keywords: Cloning, Molecular/methods ; Cytoplasmic Granules/ultrastructure ; DNA, Recombinant ; Escherichia coli/metabolism/*ultrastructure ; Humans ; Insulin/*genetics ; Microscopy, Electron ; Plasmids
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  • 63
    Publication Date: 1982-10-29
    Description: Qualitatively distinct patterns of cardiovascular and neuroendocrine responses were observed in male college students during mental work and during sensory intake task performance. During mental work, Type A (coronary-prone) subjects showed greater muscle vasodilatation and more enhanced secretion of norepinephrine, epinephrine, and cortisol than Type B subjects. During sensory intake, Type A hyperresponsivity was found for testosterone and, among those subjects with a positive family history of hypertension, for cortisol. As a demonstration of combined cardiovascular, sympathetic nervous system, and neuroendocrine hyperresponsivity to specific cognitive tasks in Type A subjects, this study breaks ground in the search for mechanisms mediating the increased coronary disease risk among Type A persons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, R B Jr -- Lane, J D -- Kuhn, C M -- Melosh, W -- White, A D -- Schanberg, S M -- HL-22740/HL/NHLBI NIH HHS/ -- MH-6489/MH/NIMH NIH HHS/ -- MH-70482/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):483-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123248" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/*physiology ; Blood Pressure ; Cardiovascular Diseases/etiology ; Cognition/*physiology ; Hemodynamics ; Hormones/blood ; Humans ; Hydrocortisone/blood ; Risk
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 64
    Publication Date: 1982-11-05
    Description: Context, specifically the perceived figure or ground of an ambiguous form that surrounds a diagonal line segment, can influence the discrimination of that line segment even though the physical attributes of the context remain the same during figure-ground reversals. When the line segment was flashed on a region of the form seen as figure, discrimination was twice as accurate as when the line segment was flashed in isolation, and it was at least three times as accurate as when the line segment was flashed on that same region seen as ground.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, E -- Weisstein, N -- EY-03432/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):587-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123261" target="_blank"〉PubMed〈/a〉
    Keywords: Discrimination (Psychology)/physiology ; Form Perception/*physiology ; Humans ; Visual Perception/*physiology
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  • 65
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yalow, R S -- New York, N.Y. -- Science. 1982 Nov 19;218(4574):742.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134970" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents ; Humans ; Hyperthyroidism/*radiotherapy ; Iodine Radioisotopes/*adverse effects ; Neoplasms, Radiation-Induced/etiology ; *Nuclear Energy ; Potassium Iodide/*therapeutic use ; Radiotherapy/adverse effects ; Thyroid Neoplasms/etiology
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  • 66
    Publication Date: 1982-08-20
    Description: The transmission of adult T cell leukemia virus, a human retrovirus, into fresh leukocytes from normal humans was examined. One of three virus-carrying cell lines, tested after being subjected to lethal x-irradiation, consistently transformed leukocytes from adult peripheral blood and umbilical cord blood. All the transformed cell lines expressed adult T cell leukemia virus-associated antigen, but transformed lines originating from adult and umbilical cord blood exhibited T cell and non-T, non-B cell surface natures, respectively. Efforts to transform human leukocytes with cell-free virus were unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamamoto, N -- Okada, M -- Koyanagi, Y -- Kannagi, M -- Hinuma, Y -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6980467" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; Cell Line ; Fetal Blood ; Genes, Viral ; Humans ; Karyotyping ; Leukocytes/*physiology ; Retroviridae/*genetics ; T-Lymphocytes/immunology ; *Transformation, Genetic
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  • 67
    Publication Date: 1982-01-22
    Description: The molecular weight (as determined by molecular sieve chromatography) of human gamma interferon, formerly referred to as immune or type II interferon, is between 40,000 and 70,000. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gamma interferon activity was recovered mainly from two regions of the gels corresponding to molecular weights of 20,000 and 25,000. The results suggest that in native form human gamma interferon may be aggregated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yip, Y K -- Barrowclough, B S -- Urban, C -- Vilcek, J -- R01-AI-07057/AI/NIAID NIH HHS/ -- R01-AI-12948/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6173921" target="_blank"〉PubMed〈/a〉
    Keywords: Glycoproteins ; Humans ; *Interferons ; Lymphocytes ; Macromolecular Substances ; Molecular Weight
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  • 68
    Publication Date: 1982-01-08
    Description: Prompt and long-term closure of full-thickness skin wounds is guinea pigs and humans is achieved by applying a bilayer polymeric membrane. The membrane comprises a top layer of a silicone elastomer and a bottom layer of a porous cross-linked network of collagen and glycosaminoglycan. The bottom layer can be seeded with a small number of autologous basal cells before grafting. No immunosuppression is used and infection, exudation, and rejection are absent. Host tissue utilizes the sterile membrane as a culture medium to synthesize neoepidermal and neodermal tissue. A functional extension of skin over the entire wound area is formed in about 4 weeks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yannas, I V -- Burke, J F -- Orgill, D P -- Skrabut, E M -- GM 21700/GM/NIGMS NIH HHS/ -- GM 23946/GM/NIGMS NIH HHS/ -- HL 14322/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031899" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Burns/*therapy ; Cells, Cultured ; Child ; Child, Preschool ; Collagen/therapeutic use ; Female ; Glycosaminoglycans/therapeutic use ; Guinea Pigs ; Humans ; Male ; Middle Aged ; Silicone Elastomers/therapeutic use ; *Skin Transplantation ; *Wound Healing
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-03-19
    Description: Man, gorilla, and chimpanzee likely shared an ancestor in whom the fine genetic organization of chromosomes was similar to that of present man. A comparative analysis of high-resolution chromosomes from orangutan, gorilla, chimpanzee, and man suggests that 18 or 23 pairs of chromosomes of modern man are virtually identical to those of our "common hominoid ancestor", with the remaining pairs slightly different. From this lineage, gorilla separated fist, and three major chromosomal rearrangements presumably occurred in a progenitor of chimpanzee and man before the final divergence of these tow species. A precursor of the hominoid ancestor and orangutan is also assumed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yunis, J J -- Prakash, O -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1525-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063861" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Chromosome Banding ; Chromosomes, Human/*ultrastructure ; Humans ; Karyotyping/methods ; Primates/*genetics
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  • 70
    Publication Date: 1982-09-17
    Description: Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations suggest a possible role for type II collagen autoimmunity in the etiology of otosclerosis and Meniere's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoo, T J -- Stuart, J M -- Kang, A H -- Townes, A S -- Tomoda, K -- Dixit, S -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1153-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112122" target="_blank"〉PubMed〈/a〉
    Keywords: Autoantibodies/analysis ; Autoimmune Diseases/*immunology ; Collagen/classification/*immunology ; Humans ; Meniere Disease/*immunology ; Osteosclerosis/*immunology
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  • 71
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-24
    Description: Using a task known to be sensitive to human amnesia, we have evaluated two current hypotheses about which brain regions must be damaged to produce the disorder. Monkeys with bilateral transections of the white matter of the temporal stem were unimpaired, but monkeys with conjoint amygdala-hippocampal lesions exhibited a severe memory deficit. The results indicate that the hippocampus, amygdala, or both, but not the temporal stem, are involved in memory in the monkey and suggest that a rapprochement between the findings for the human and the nonhuman primate may be close at hand.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zola-Morgan, S -- Squire, L R -- Mishkin, M -- MH24600/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890713" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/*etiology ; Amygdala/*physiology ; Animals ; Brain Injuries/complications ; Brain Stem/*physiology ; Disease Models, Animal ; Hippocampus/*physiology ; Humans ; Macaca fascicularis ; *Memory
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  • 72
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 9;222(4628):1072-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648522" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Costs and Cost Analysis ; Humans ; Neoplasms/*prevention & control
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Oct 14;222(4620):118-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623060" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Multiple Myeloma/*etiology ; Neoplasms, Radiation-Induced/*etiology ; Nuclear Warfare ; *Veterans Disability Claims
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉HD-12572/HD/NICHD NIH HHS/ -- MH-00318/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):74-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623059" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Child, Preschool ; *Eye Movements ; Humans ; Research Design
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Apr 8;220(4593):142, 144, 146.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828887" target="_blank"〉PubMed〈/a〉
    Keywords: Dental Caries/*prevention & control ; *Fluoridation ; Humans ; United States
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-23
    Description: The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ames, B N -- ES01896/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1256-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6351251" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; *Carcinogens/antagonists & inhibitors ; Cocarcinogenesis ; Diet/*adverse effects ; Dietary Fats/adverse effects ; Free Radicals ; Hot Temperature ; Humans ; Lipid Peroxides/adverse effects ; Mutagens ; Oxygen/*toxicity ; Plants, Edible ; Smoking
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  • 77
    Publication Date: 1983-04-29
    Description: Suitably brief pulses of selectively absorbed optical radiation can cause selective damage to pigmented structures, cells, and organelles in vivo. Precise aiming is unnecessary in this unique form of radiation injury because inherent optical and thermal properties provide target selectivity. A simple, predictive model is presented. Selective damage to cutaneous microvessels and to melanosomes within melanocytes is shown after 577-nanometer (3 x 10(-7) second) and 351-nanometer (2 x 10(-8) second) pulses, respectively. Hemodynamic, histological, and ultrastructural responses are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, R R -- Parrish, J A -- R01025395/PHS HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):524-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836297" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Hot Temperature ; Humans ; *Laser Therapy ; Melanins/metabolism ; Melanocytes/ultrastructure ; Microcirculation/surgery ; Microscopy, Electron ; Microsurgery/*methods
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-27
    Description: Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antoniades, H N -- Hunkapiller, M W -- CA30101/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):963-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844921" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Electrophoresis, Polyacrylamide Gel ; Growth Substances/genetics/*metabolism ; Humans ; Molecular Weight ; Peptides/genetics/*metabolism ; Platelet-Derived Growth Factor
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The exposure of the population of Utah to external gamma-radiation from the fallout from nuclear weapons tests carried out between 1951 and 1958 at the Nevada Test Site has been reconstructed from recent measurements of residual cesium-137 and plutonium in soil. Although the highest exposures were found in the extreme southwest part of Utah, as expected, the residents of the populous northern valleys around Provo, Salt Lake City, and Ogden received a higher mean dose and a significantly greater population dose (person-rads) than did the residents of most counties closer to the test site. However, population doses from external exposure throughout Utah were far too low to result in any statistically observable health effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beck, H L -- Krey, P W -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828876" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Exposure ; Gamma Rays ; Humans ; Leukemia/etiology ; Nevada ; *Nuclear Warfare ; *Radiation ; Radiation Dosage ; Utah
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  • 80
    Publication Date: 1983-06-17
    Description: Animals with a history of receiving daily injections of +-amphetamine in a specific environment showed a placebo effect (enhanced activity) when injected with saline and placed there; control animals with similar but dissociated drug histories and experience with the test chamber failed to show the effect. The dopamine receptor blocker pimozide antagonized the establishment of conditioning. However, the same dose of pimozide, when given to previously conditioned animals on the placebo test day, failed to antagonize the expression of conditioned activity. Thus, during conditioning dopaminergic neurons mediated a change that subsequently influenced behavior even when dopaminergic systems were blocked. Although schizophrenia may be related to hyperfunctioning of dopamine, neuroleptic drugs, which block dopamine receptors on their first administration, do not have therapeutic effects for a number of days. The results of the pimozide experiments may resolve this paradox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beninger, R J -- Hahn, B L -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology)/*drug effects/physiology ; Dextroamphetamine/antagonists & inhibitors/*pharmacology ; Humans ; Male ; Pimozide/*pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/physiology ; Reinforcement (Psychology) ; Schizophrenia/physiopathology
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  • 81
    Publication Date: 1983-04-29
    Description: Selective pharmacological inhibition of thromboxane A2 synthesis did not prevent arachidonate-induced aggregation of human platelets in vitro. Prevention was instead achieved by a combination of thromboxane A2 inhibitors with low concentrations of aspirin. The latter partially reduced the proaggregatory cyclooxygenase products that accumulated when thromboxane A2 synthesis was blocked. The aspirin concentrations did not affect per se either platelet aggregation or prostacyclin synthesis in cultured human endothelial cells. The combination of thromboxane synthetase inhibitors with low doses of aspirin may offer greater antithrombotic potential than either drug alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bertele, V -- Falanga, A -- Tomasiak, M -- Dejana, E -- Cerletti, C -- de Gaetano, G -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):517-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682245" target="_blank"〉PubMed〈/a〉
    Keywords: Aspirin/*pharmacology ; Blood Platelets/*drug effects/enzymology ; Dose-Response Relationship, Drug ; Drug Interactions ; Humans ; Imidazoles/pharmacology ; Methacrylates/pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Platelet Aggregation/drug effects ; Thromboxane-A Synthase/*antagonists & inhibitors
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: Monkeys in which nerves innervating the flexor muscles of the forearm and hand (the ulnar or the median nerve) had been surgically cross-united with the nerve innervating the extensor muscles (the radial nerve), and vice versa, showed excellent (ulnar-radial crosses) to moderate (median-radial crosses) control of movement performance after regeneration. Antagonistic movement responses were seen occasionally, but these were corrected almost immediately. Stimulation of the crossed nerves showed that they had innervated the antagonistic muscle groups. The results reveal the capacity of the primate central nervous system to adapt to gross disturbances imposed on the execution of movements by changes in peripheral innervation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinkman, C -- Porter, R -- Norman, J -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):438-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836289" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fingers/physiology ; Forearm/*innervation/physiology ; Hand/innervation/physiology ; Humans ; Macaca fascicularis ; Macaca nemestrina ; Median Nerve/physiology ; *Movement ; *Neuronal Plasticity ; Radial Nerve/physiology ; Thumb/physiology ; Ulnar Nerve/physiology
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capron, Alexander M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644013" target="_blank"〉PubMed〈/a〉
    Keywords: Coercion ; Humans ; Mandatory Programs ; *Public Policy ; *Tissue Donors ; *Tissue and Organ Procurement ; United States ; Voluntary Programs
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  • 84
    Publication Date: 1983-01-28
    Description: The defensive siphon and gill withdrawal reflex of Aplysia is a simple reflex mediated by a well-defined neural circuit. This reflex exhibits classical conditioning when a weak tactile stimulus to the siphon is used as a conditioned stimulus and a strong shock to the tail is used as an unconditioned stimulus. The siphon withdrawal component of this reflex can be differentially conditioned when stimuli applied to two different sites on the mantle skin (the mantle shelf and the siphon) are used as discriminative stimuli. The differential conditioning can be acquired in a single trial, is retained for more than 24 hours, and increases in strength with increased trials. Differential conditioning can also be produced within the field of innervation of a single cluster of sensory neurons (the LE cluster) since two separate sites on the siphon skin can serve as discriminative stimuli. The finding that two independent afferent inputs that activate a common set of interneurons and motor neurons can be differentially conditioned restricts the possible cellular loci involved in the associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carew, T J -- Hawkins, R D -- Kandel, E R -- 5KO2 M0081/PHS HHS/ -- 5KO5 MH18558/MH/NIMH NIH HHS/ -- NS 12744/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):397-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681571" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Aplysia/*physiology ; Conditioning, Classical/*physiology ; *Defense Mechanisms ; Humans ; Memory ; Reflex
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  • 85
    Publication Date: 1983-01-28
    Description: A commercial alpha-amylase inhibitor with potent inhibitory activity in vitro was used in a randomized double-blind, cross-over clinical trial in six nonobese, healthy adult males. In these subjects, this inhibitor had no effect on the response of blood glucose, insulin, or breath hydrogen to a standardized starch meal. It is concluded that this formulation has no effect on starch digestion in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlson, G L -- Li, B U -- Bass, P -- Olsen, W A -- 5P30 AM 26659/AM/NIADDK NIH HHS/ -- AM 13927/AM/NIADDK NIH HHS/ -- AM 21668/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):393-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6184780" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/*antagonists & inhibitors ; Blood Glucose/metabolism ; Dietary Carbohydrates/*metabolism ; Humans ; Hydrogen/metabolism ; Insulin/blood ; alpha-Amylases/*antagonists & inhibitors
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charrow, R P -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857235" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic/*legislation & jurisprudence ; Drug Industry ; *Drug Prescriptions ; Humans ; United States
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-26
    Description: The rate of increase of population in less developed countries accelerated rapidly from 1850 to 1960 because of a rapid decline in mortality while fertility remained high. In the 1960's, the birth rate as a whole began to decline more rapidly than the death rate--very rapidly in some populations, most notably that of China, more gradually in others, and not at all in some of the poorest populations. The momentum of growth implies continued increase in populations for several decades even in countries where fertility has fallen the most, and very large additional increases where there has been no decline in the rate of childbearing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coale, A J -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):828-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879179" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Birth Rate ; *Developing Countries ; Female ; *Fertility ; Humans ; Marriage ; Parity ; Pregnancy
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, Barbara J -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1029.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643993" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Fraud ; Humans ; *Research ; Research Personnel ; *Scientific Misconduct
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  • 89
    Publication Date: 1983-07-01
    Description: Mammalian atrial extracts possess natriuretic and diuretic activity. In experiments reported here it was found that atrial, but not ventricular, extract also causes relaxation of isolated vascular and nonvascular smooth muscle preparations. The smooth muscle relaxant activity of atrial extract was heat-stable and concentration-dependent and could be destroyed with protease. Rabbit aortic and chick rectum strips were used for the detection of atrial biological activity. The atrial activity was separated by column chromatography into two peaks having apparent molecular weights of 20,000 to 30,000 and less than 10,000. The atrial substance that copurified with the smooth muscle relaxant activity in both peaks caused natriuresis when injected into conscious rats. It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, M G -- Geller, D M -- Cole, B R -- Boylan, J G -- YuSheng, W -- Holmberg, S W -- Needleman, P -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857267" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Atrial Function ; Chickens ; Chromatography, Gel ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Molecular Weight ; Muscle, Smooth/drug effects ; Muscle, Smooth, Vascular/*drug effects ; Natriuresis/drug effects ; Rabbits ; Rats ; Swine ; Vasodilation/drug effects
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  • 90
    Publication Date: 1983-07-08
    Description: A diffusible factor produced and secreted by malignant murine cells was capable of inducing plasminogen activator production by normal diploid human fibroblasts. The factor's ability to induce plasminogen activator was insensitive to treatment with nucleases, but its activity was destroyed by digestion with proteases. It is proposed that such a factor would play a role in malignancy if it would recruit normal cells that were adjacent to transformed cells to produce plasminogen activator which could result in tumor-promoted proteolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, R L -- Rifkin, D B -- Tepper, R -- Miller, A -- Kucherlapati, R -- CA-16239/CA/NCI NIH HHS/ -- CA-35171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Fibroblasts/drug effects/metabolism ; Humans ; Hybrid Cells/metabolism ; Melanoma/metabolism ; Mice ; Neoplasms, Experimental/*metabolism/secretion ; Peptides/pharmacology/*secretion ; Plasminogen Activators/*biosynthesis ; Rats
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: The external and internal interosseous intercostal muscles were separately stimulated at end-expiratory lung volume in anesthetized dogs. These muscles were all found to elevate the ribs into which they insert. By attaching weights to the ribs, it was determined that the nonlinear compliance of the ribs was responsible for this phenomenon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Troyer, A -- Kelly, S -- Zin, W A -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):87-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Dogs ; Electric Stimulation ; Humans ; Intercostal Muscles/anatomy & histology/*physiology ; Respiration ; Ribs/anatomy & histology/*physiology
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dermer, G B -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):318.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; *Neoplasms ; Neoplasms, Experimental ; Rats ; Research
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeSimone, J A -- NS13767/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):221-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828892" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diffusion ; Humans ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism/*physiology ; Peptides/metabolism ; Sucrose/metabolism
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  • 94
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-15
    Description: Artificial intelligence, long a topic of basic computer science research, is now being applied to problems of scientific, technical, and commercial interest. Some consultation programs, although limited in versatility, have achieved levels of performance rivaling those of human experts. A collateral benefit of this work is the systematization of previously unformalized knowledge in areas such as medical diagnosis and geology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duda, R O -- Shortliffe, E H -- LM-00048/LM/NLM NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6340198" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; *Computers ; Diagnosis, Computer-Assisted ; Humans ; Research ; Systems Analysis
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-09
    Description: Nonmalignant diploid human fibroblast cells (GM3498B) derived from a skin biopsy of a patient with Bloom's syndrome have been transformed by transfection with DNA from a tumorigenic mouse cell line (Ha-8) carrying a single copy of the Harvey murine sarcoma virus (Ha-MuSV) genome. The transformed cell lines have an extended life-span, form colonies in agarose, and proliferate in nude mice--characteristics of neoplastic transformation. Like the parental cells, they also exhibit a high spontaneous level of sister chromatid exchanges. Finally, the transformed cells contain most, if not all, of the Ha-MuSV genome as well as the human rasH sequence. These experiments show that these diploid nonmalignant human cells can be used as recipients in transfection experiments for studying the genetic control of neoplastic transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doniger, J -- Di Paolo, J A -- Popescu, N C -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1144-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648529" target="_blank"〉PubMed〈/a〉
    Keywords: Bloom Syndrome/*genetics ; Cell Adhesion ; *Cell Transformation, Neoplastic ; Cells, Cultured ; DNA, Neoplasm/*genetics ; Humans ; Oncogenes ; Transfection
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doverspike, Dennis -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):506.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644015" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavioral Research ; Civil Rights ; Ethics, Professional ; Human Rights ; Humans ; *Research ; *Research Personnel ; *Scientific Misconduct ; *Social Control, Informal ; Students ; *Universities
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: The forensic use of hypnosis is increasing. A hypermnesic procedure was used in an experiment that calls this practice into question. Subjects tried for a week to recall 60 previously presented pictures. They were then either hypnotized or not and encouraged to recall even more pictures. Most of the newly recalled material was incorrect, especially for highly hypnotizable subjects in the hypnosis condition. Such errors in recall can have profound implications for forensic investigations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dywan, J -- Bowers, K -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):184-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623071" target="_blank"〉PubMed〈/a〉
    Keywords: Forensic Psychiatry/methods ; Humans ; *Hypnosis ; Memory/*physiology ; Mental Recall/*physiology
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  • 98
    Publication Date: 1983-12-23
    Description: Subfreezing temperatures, low light levels, and high doses of ionizing and ultraviolet radiation extending for many months after a large-scale nuclear war could destroy the biological support systems of civilization, at least in the Northern Hemisphere. Productivity in natural and agricultural ecosystems could be severely restricted for a year or more. Postwar survivors would face starvation as well as freezing conditions in the dark and be exposed to near-lethal doses of radiation. If, as now seems possible, the Southern Hemisphere were affected also, global disruption of the biosphere could ensue. In any event, there would be severe consequences, even in the areas not affected directly, because of the interdependence of the world economy. In either case the extinction of a large fraction of the Earth's animals, plants, and microorganisms seems possible. The population size of Homo sapiens conceivably could be reduced to prehistoric levels or below, and extinction of the human species itself cannot be excluded.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrlich, P R -- Harte, J -- Harwell, M A -- Raven, P H -- Sagan, C -- Woodwell, G M -- Berry, J -- Ayensu, E S -- Ehrlich, A H -- Eisner, T -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1293-300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658451" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Climate ; *Environment ; Humans ; *Nuclear Warfare ; Photosynthesis ; Radiation, Ionizing ; Radioactive Fallout ; Sunlight ; Temperature ; Ultraviolet Rays
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  • 99
    Publication Date: 1983-09-02
    Description: Extracts from adult human adrenals contained high concentrations of immunoreactive beta-endorphin and alpha-melanotropin. Lower quantities of immunoreactive adrenocorticotropic hormone could also be detected. Distribution studies showed the presence of pro-opiomelanocortin fragments in the adrenal medulla. No alpha-melanotropin, beta-endorphin, or adrenocorticotropic hormone could be found in adrenal extracts from several other mammalian species. Analysis of the beta-endorphin-like immunoreactivity using region specific radioimmunoassays interfacing with gel filtration and reverse-phase high-performance liquid chromatography showed the majority of the beta-endorphin-like material to exist as nonacetylated beta-endorphin-(1-31) with a small percentage of lipotropin-sized molecules. The alpha-melanotropin-like immunoreactivity cochromatographed on gel filtration and reverse-phase high-performance liquid chromatography with desacetyl alpha-melanotropin. The data suggest that pro-opiomelanocortin is expressed in the adrenal medulla of humans but is not detectable in the adrenal glands of many other mammalian species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evans, C J -- Erdelyi, E -- Weber, E -- Barchas, J D -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):957-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308766" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex/analysis ; Adrenal Medulla/*analysis ; Adrenocorticotropic Hormone/analysis ; Endorphins/analysis ; Humans ; Melanocyte-Stimulating Hormones/analysis ; Pituitary Hormones, Anterior/*analysis/metabolism ; Pro-Opiomelanocortin ; Protein Precursors/*analysis/metabolism ; Radioimmunoassay
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-23
    Description: Three-month-old infants learned to activate an overhead crib mobile by operant footkicking and received a visual reminder of the event (a "reactivation treatment") 2 weeks later, after forgetting had occurred. Subsequent manifestation of the association was a monotonic increasing function of time since the reactivation treatment, and performance of infants tested 8 hours after the remainder was related to the time spent sleeping in the interim (r = 0.75). These data demonstrate that normal retrieval is time-dependent. Moreover, individual data suggest that retrieval may be continuous rather than discontinuous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fagen, J W -- Rovee-Collier, C -- MH 32307/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658456" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Infant ; *Memory ; Time Factors
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