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  • Chemistry  (20,447)
  • Cell & Developmental Biology  (1,881)
  • AERODYNAMICS  (1,383)
  • METEOROLOGY AND CLIMATOLOGY  (1,151)
  • 1980-1984  (24,862)
  • 1930-1934
  • 1925-1929
  • 1984  (8,368)
  • 1983  (8,109)
  • 1982  (8,385)
Collection
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  • 1980-1984  (24,862)
  • 1930-1934
  • 1925-1929
Year
  • 1
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 2
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 3
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 4
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 5
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 6
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 7
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 8
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
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  • 9
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 10
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 11
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 12
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 13
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 14
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 15
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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  • 16
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    In-flight lift and drag measurements on a first generation jet transport equipped with winglets (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A KC-135A aircraft equipped with wing tip winglets was flight tested to demonstrate and validate the potential performance gain of the winglet concept as predicted from analytical and wind tunnel data. Flight data were obtained at cruise conditions for Mach numbers of 0.70, 0.75, and 0.80 at a nominal altitude of 36,000 ft. and winglet configurations of 15 deg cant/-4 deg incidence, 0 deg cant/-4 deg incidence, and baseline. For the Mach numbers tested the data show that the addition of winglets did not affect the lifting characteristics of the wing. However, both winglet configurations showed a drag reduction over the baseline configuration, with the best winglet configuration being the 15 deg cant/-4 deg incidence configuration. This drag reduction due to winglets also increased with increasing lift coefficient. It was also shown that a small difference exists between the 15 deg cant/-4 deg incidence flight and wind tunnel predicted data. This difference was attributed to the pillowing of the winglet skins in flight which would decrease the winglet performance.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 103-116
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    KC-135 winglet program overview (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A joint NASA/USAF program was conducted to accomplish the following objectives: (1) evaluate the benefits that could be achieved from the application of winglets to KC-135 aircraft; and (2) determine the ability of wind tunnel tests and analytical analysis to predict winglet characteristics. The program included wind-tunnel development of a test winglet configuration; analytical predictions of the changes to the aircraft resulting from the application of the test winglet; and finally, flight tests of the developed configuration. Pressure distribution, loads, stability and control, buffet, fuel mileage, and flutter data were obtained to fulfill the objectives of the program.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 1-46
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    KC-135 wing and winglet flight pressure distributions, loads, and wing deflection results with some wind tunnel comparisons (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A full-scale winglet flight test on a KC-135 airplane with an upper winglet was conducted. Data were taken at Mach numbers from 0.70 to 0.82 at altitudes from 34,000 feet to 39,000 feet at stabilized flight conditions for wing/winglet configurations of basic wing tip, 15/-4 deg, 15/-2 deg, and 0/-4 deg winglet cant/incidence. An analysis of selected pressure distribution and data showed that with the basic wing tip, the flight and wind tunnel wing pressure distribution data showed good agreement. With winglets installed, the effects on the wing pressure distribution were mainly near the tip. Also, the flight and wind tunnel winglet pressure distributions had some significant differences primarily due to the oilcanning in flight. However, in general, the agreement was good. For the winglet cant and incidence configuration presented, the incidence had the largest effect on the winglet pressure distributions. The incremental flight wing deflection data showed that the semispan wind tunnel model did a reasonable job of simulating the aeroelastic effects at the wing tip. The flight loads data showed good agreement with predictions at the design point and also substantiated the predicted structural penalty (load increase) of the 15 deg cant/-2 deg incidence winglet configuration.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 47-102
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    Status of advanced airfoil tests in the Langley 0.3-meter transonic cryogenic tunnel (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A joint NASA/U.S. industry program to test advanced technology airfoils in the Langley 0.3-meter Transonic Tunnel (TCT) was formulated under the Langley ACEE Project Office. The objectives include providing U.S. industry an opportunity to compare their most advanced airfoils to the latest NASA designs by means of high Reynolds number tests in the same facility. At the same time, industry would again experience in the design and construction of cryogenic test techniques. The status and details of the test program are presented. Typical aerodynamic results obtained, to date, are presented at chord Reynolds number up to 45 x 10(6) and are compared to results from other facilities and theory. Details of a joint agreement between NASA and the Deutsche Forschungs- und Versuchsantalt fur Luft- and Raumfahrt e.V. (DFVLR) for tests of two airfoils are also included. Results of these tests will be made available as soon as practical.
    Keywords: AERODYNAMICS
    Type: Advan. Aerodyn.: Selected NASA Res.; p 37-53
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    Joint Airport Weather Studies (AWS) project (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The joint airport weather studies (JAWS) project is discussed. The major objectives of the JAWS Project are a fundamental description of the phenomenon, a determination of the hazard potential and a definition of a protection and warning system, all of which are relative to low level wind shear. Aspects of the low level wind shear phenomenon. The principal focus, however, is the microburst. The microburst is fundamentally a rather simple atmospheric flow. It is a downdraft that, upon approaching the surface, spreads out horizontally, producing a diverging radial flow in all directions. For any direction that an aircraft flies through the microburst, it will first encounter increasing head winds; then the remnants of the downdraft; and then, increasing tail wind.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 85-95
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    Lightning strike experience in the NASA F-106B storm hazards program (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A heavily instrumented F-106B aircraft was flown in thunderstorms to gather data for characterizing lightning at aircraft operating altitudes. Conventional weather finding techniques are supplemented with UHF lightning mapping radar to select the most active storm cells and the most likely altitude for obtaining direct lightning strikes to the airplane. One hundred seventy-six strikes were obtained in a 3 year period, mostly at an altitude of above 25,000 feet.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 63-65
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    Wind shear and vortex wake research in UK, 1982 (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A wind shear and vortex wake and their impact on aircraft were investigated. The systems and advice to help pilots, and rational scientific methods to assist in advising certification authorities and those interested in improving flight safety were developed. Wind Shear and Vortex Wakes are related, they are both invisible enemies of aircraft in the form of large disturbances in the atmosphere, both cause major accidents. Problems of building wakes at airports are is considered. Research on wind shear was initiated by the American FAA following the Boston, New York and Denver accidents to civil airliners. This resulted in: useful advice to pilots about wind shear; better attempts by the meteorologists at forecasting wind shear conditions; and useful ideas for wind shear measurement and warning systems. Three major research tasks are outstanding: (1) Worldwide measurements to give reliable estimates of probability and details of the forms of large wind shears; (2) Developments of real time wind shear measuring systems for ground or airborne use; and (3) Establishing relationships between measured wind shear and the potential hazard to an aircraft, or class of aircraft.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 66-83
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    Marked surface inversions and wind shear: A safety risk for departing aircraft (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Marked surface inversions occur most frequently in dry continental climates, where low atmospheric humidity allows heat transfer by long wave thermal radiation. In the northern latitudes, surface inversions reach their maximum intensity during the winter, when the incoming Sun's radiation is negligible and radiative cooling is dominant during the long nights. During winter, air mass boundaries are sharp, which causes formation of marked surface inversions. The existence of these inversions and sharp boundaries increase the risk of wind shear. The information should refer to marked inversions exceeding a temperature difference of 10 deg C up to 1000 feet. The need to determine the temperature range over which he information is operationally needed and the magnitude of the inversion required before a notification to pilots prior to departure is warranted are outlined.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 61-62
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  • 34
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    A cursory glance at results from NASA's B-57B gust gradient program (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The Gust Gradient Program is a data intensive effort involving tripple Doppler radar, a surface weather station mesonet and other aircraft. The Joint Airport Weather Studies was utilized to gain additional data. The data were used to fill in the gap in turbulence modeling.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 38-42
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  • 35
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    GEM: Statistical weather forecasting procedure (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The objective of the Generalized Exponential Markov (GEM) Program was to develop a weather forecast guidance system that would: predict between 0 to 6 hours all elements in the airways observations; respond instantly to the latest observed conditions of the surface weather; process these observations at local sites on minicomputing equipment; exceed the accuracy of current persistence predictions at the shortest prediction of one hour and beyond; exceed the accuracy of current forecast model output statistics inside eight hours; and be capable of making predictions at one location for all locations where weather information is available.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 42-44
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    Department of Defense meteorological and environmental inputs to aviation systems (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Recommendations based on need, cost, and achievement of flight safety are offered, and the re-evaluation of weather parameters needed for safe landing operations that lead to reliable and consistent automated observation capabilities are considered.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 19-20
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    Aviation weather services (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The primary responsibilities of the National Weather Service (NWS) are to: provide warnings of severe weather and flooding for the protection of life and property; provide public forecasts for land and adjacent ocean areas for planning and operation; and provide weather support for: production of food and fiber; management of water resources; production, distribution and use of energy; and efficient and safe air operations.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 14-16
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    Federal Aviation Administration weather program to improve aviation safety (1983)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The implementation of the National Airspace System (NAS) will improve safety services to aviation. These services include collision avoidance, improved landing systems and better weather data acquisition and dissemination. The program to improve the quality of weather information includes the following: Radar Remote Weather Display System; Flight Service Automation System; Automatic Weather Observation System; Center Weather Processor, and Next Generation Weather Radar Development.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center Proc.: 6th Ann. Workshop on Meteorol. and Environ. Inputs to Aviation Systems; p 21-25
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  • 39
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    Development of the operational program for satellite meteorology (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: The geostationary and polar satellites comprising the current operational system are discussed. The data acquisition capabilities of both satellite types and their complementary functions are reviewed. The advanced very high resolution radiometer on the TIROS N satellites is particularly addressed along with the imaging and atmospheric sounding instrumentation aboard the GOES satellites. The dissemination of the satellite data to the prospective users is also discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 34-40
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  • 40
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    Early program development and implementation (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: Programs for the development and operation of meteorological satellites from the TIROS 1 satellite and the establishment of NASA through the 1960's are described. The technical problems confronted in the development of the early satellite systems are discussed in addition to issues in international involvement and program support. The TIROS and Nimbus series satellites are primarily addressed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 5-33
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  • 41
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    The climatic effect of explosive volcanic activity: Analysis of the historical data (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: By using the most complete available records of direct beam radiation and volcanic eruptions, an historical analysis of the role of the latter in modulating the former was made. A very simple fallout and dispersion model was applied to the historical chronology of explosive eruptions. The resulting time series explains about 77 percent of the radiation variance, as well as suggests that tropical and subpolar eruptions are more important than mid-latitude eruptions in their impact on the stratospheric aerosol optical depth. The simpler climatic models indicate that past hemispheric temperature can be stimulated very well with volcanic and CO2 inputs and suggest that climate forecasting will also require volcano forecasting. There is some evidence that this is possible some years in advance.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 191-202
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  • 42
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    Distribution of Mount St. Helens dust inferred from satellites and meteorological data (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: Visible and infrared pictures from two Geostationary Operational Environmental Satellite Systems satellites, in circular orbits at about 19,000 nautical miles, are available continuously at approximately 30 minute intervals. Still pictures and film loops from this system vividly depict the events associated with the May 18, 1980 eruption of Mount St. Helens. The initial explosion, shock wave, and visible horizontal dust distribution during the following week are readily apparent. Meteorological wind and height fields permit the inference of the vertical distribution of volcanic dust as well as explain the atmospheric behavior which caused the visible and nonvisible dust distribution.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 131-140
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  • 43
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    Comments on satellite meteorology from geostationary satellites (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: Examples of the use of geostationary satellites in meteorology are given. Studies of the rate of change of cumulus clouds and cloud systems and wind parameter determination from cloud motions are reviewed. Computer processed imagery products are also discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 72-83
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  • 44
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    Military applications evolution and future (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: The Defense Meteorological Satellite Program is described with particular emphasis on the military applications of METSAT data. Satellite operational support, data processing and image quality requirements are discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 41-47
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  • 45
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    Early satellite program developments (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: A historical overview of the pioneer projects for the development of meteorological satellites is given. In addition, the parallel development of the responsible space agencies and panels is addressed. The Vanguard 2 satellite, the first Earth radiation experiment, and the vidicon equipped TIROS-1 satellite are discussed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 1-4
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  • 46
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    Problems in the climatology of the 1980 Mount St. Helens eruptions (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: A brief review of the effects of climate and weather on the 1980 Mount St. Helens eruptions and the subsequent dispersion of ash and gases and the reciprocal influences of the eruptions on climate and climatology is presented. The effects of mesoscale destruction of snow fields and vegetation, a revised mountain profile, and ash deposits are addressed along with impacts on hemispheric climate and disruption of normal climatological observations, in the areas directly affected by the explosions and ashfall. Environmental and economic consequences are also considered.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 203-209
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  • 47
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    Component testing for dynamic model verification (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Dynamic model verification is the process whereby an analytical model of a dynamic system is compared with experimental data, adjusted if necessary to bring it into agreement with the data, and then qualified for future use in predicting system response in a different dynamic environment. These are various ways to conduct model verification. The approach taken here employs Bayesian statistical parameter estimation. Unlike curve fitting, whose objective is to minimize the difference between some analytical function and a given quantity of test data (or curve), Bayesian estimation attempts also to minimize the difference between the parameter values of that funciton (the model) and their initial estimates, in a least squares sense. The objectives of dynamic model verification, therefore, are to produce a model which: (1) is in agreement with test data; (2) will assist in the interpretation of test data; (3) can be used to help verify a design; (4) will reliably predict performance; and (5) in the case of space structures, will facilitate dynamic control.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Recent Experiences in Multidisciplinary Analysis and Optimization, Part 2; 15 p
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  • 48
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    Post and a random-walk search mode (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Multidisciplinary analysis often requires optimization of nonlinear systems that are subject to constraints. Trajectory optimization is one example of this situation. The Program to Optimize Simulated Trajectories (POST) was used successfully for a number of problems. The purpose is to describe POST and a new optimization approach that has been incorporated into it. Typical uses of POST will also be illustrated. The projected-gradient approach to optimization is the preferred option in POST and is discussed. A new approach to optimization, the random-walk approach, is described, and results with the random-walk approach are presented.
    Keywords: AERODYNAMICS
    Type: Recent Experiences in Multidisciplinary Analysis and Optimization, Part 2; 23 p
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  • 49
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    Lightning research: A user's lament (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: As a user of devices and procedures for lightning protection, the author is asking the lightning research community for cookbook recipes to help him solve his problems. He is lamenting that realistic devices are scarce and that his mission does not allow him the time nor the wherewithal to bridge the gap between research and applications. A few case histories are presented. In return for their help he is offering researchers a key to lightning technology--the use of the Eastern Test Range and its extensive resources as a proving ground for their experiment in the lightning capital of the United States. A current example is given--a joint lightning characterization project to take place there. Typical resources are listed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Intern. Aerospace and Ground Conf. on Lightning and Static Elec.; 6 p
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  • 50
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    Wall interference measurements for three-dimensional models in transonic wind tunnels: Experimental difficulties (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The purpose is not to provide a detailed discussion of several wall interference experiments, but rather to use these experiments (recently accomplished in the Boeing Transonic Wind Tunnel (BTWT) to illustrate the problems associated with many of the measurements required by current wall interference assessment/correction (WIAC) procedures. The wall correction to lift is emphasized. It is shown that, because conventional tunnels and relatively small models continue to be used, the flow field or flow boundary measurements to be made impose severe requirements on the experiment itself. In some cases, existing instrumentation and test techniques may not be adequate to obtain the data accuracies needed.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 21-42
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    Adaptation of a four-wall interference assessment/correction procedure for airfoil tests in the 0.3-m TCT (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Based upon limited, initial observations of wall interference corrections obtained for one airfoil test, there is a need for assessing the upstream flow direction. If there is no direct measurement then a two-pass correction procedure similar to the one described here is required. Questions have arisen pertaining to the correct interpretation of the pressure coefficients measured on the slats of a slotted tunnel wall, the interpretation of just what the calculated equivalent body encompasses or should include, and what can or should be considered as quantitative criteria for data correctability. Further studies using this modified procedure will address these questions. Hopefully, a meaningful WIAC procedure can be validated for the airfoil tests in the 0.3-m TCT.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 393-414
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    Some experience with Barnwell-Sewall type correction to two-dimensional airfoil data (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A series of airfoils were tested in the Langley 0.3-Meter Transonic Cryogenic Tunnel (TCT) at Reynolds numbers from 2 to 50 million. The 0.3-m TCT is equipped with Barnwell slots designed to minimize blockage due to the tunnel flow and ceiling. This design suggests that sidewall corrections for blockage is needed, and that a lifting airfoil produces a change in angle of attack. Sidewall correction methods were developed for subsonic and subsonic-transonic flow. Comparisons of theory with experimental data obtained in the 0.3-m TCT for two airfoils, the British NPL 9510 and the German R-4 are presented. The NPL 9510 was tested as part of the NASA/United Kingdom Joint Aeronautical Program and R-4 was tested as part f the DFVLR/NASA Advanced Airfoil Research Program. For the NPL 9510 airfoil, only those test points that one would anticipate being difficult to predict theoretically are presented.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 375-392
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    Experiences with a high-blockage model tested in the NASA Ames 12-foot pressure wind tunnel (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Representation of the flow around full-scale ships was sought in the subsonic wind tunnels in order to a Hain Reynolds numbers as high as possible. As part of the quest to attain the largest possible Reynolds number, large models with high blockage are used which result in significant wall interference effects. Some experiences with such a high blockage model tested in the NASA Ames 12-foot pressure wind tunnel are summarized. The main results of the experiment relating to wind tunnel wall interference effects are also presented.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 345-360
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  • 54
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    An inerference assessment approach for a three-dimensional slotted tunnel with sparse wall pressure data (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The various procedures referred to as wall interference assessment and correction procedures presume the existence of a surface distribution of data (usually static pressure) measured over a surface on or near the tunnel walls for each test point to be assessed. An alternative approach in which a reasonably sophisticated computer model of the test section flow would be fitted parametrically to a sparse set of measured data is presented. The measurements provides line distributions of static pressure near the center lines of the top, side and bottom walls. The development of a test section model incorporating explicit recognition of discrete slots of finite length with controlled flow reentry into the solid wall downstream portion of the tunnel is shown.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center. Wind Tunnel Wall Interference Assessment and Correction, 1983; p 323-334
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    A study of the geographic coverage properties of a satellite borne Doppler lidar wind velocity measuring system (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Geographic coverage frequency and geographic shot density for a satellite borne Doppler lidar wind velocity measuring system are measured. The equations of motion of the light path on the ground were derived and a computer program devised to compute shot density and coverage frequency by latitude-longitude sections. The equations for the coverage boundaries were derived and a computer program developed to plot these boundaries, thus making it possible, after an application of a map coloring algorithm, to actually see the areas of multiple coverage. A theoretical cross-swath shot density function that gives close approximations in certain cases was also derived. This information should aid in the design of an efficient data-processing system for the Doppler lidar.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 26 p
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  • 56
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    Thunderstorm electric field modelling (1982)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Calculation of eletric field vectors within and near an isolated thundercloud (which has a given volume charge distribution) is envisaged. The maximum field strength within the thundercloud is calculated. The effects of screening layers, both above and below the thundercloud may be investigated, as well time-dependent potential problem. The study can lead to a better understanding of the charge distributions in a thundercloud, which in turn may shed some light on the actual mechanism of charging of a thundercloud.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 10 p
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  • 57
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    Interference from slotted walls (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Wall interference is made predominant in tunnel models and by wall geometries to facilitate the study of slot flow. The viscous effects in slots are studied by two dimensional measurements of flow. Wall interference is assessed by measuring pressure distributions at two levels near the walls. Interference on lifting delta wings is calculated. Pressure distributions at inner boundaries show basis axisymetries between the pressure side and the suction side, pointing to the necessity of having wider slots on the pressure side.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 293-300
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    Development in UK of a method for calculating tunnel wall corrections from flow measurements (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Classical methods for calculation of wall corrections which are not satisfactory for a number of flows of interest are discussed. To meet these objections, a number of methods were developed which use measurements of the low at or close to the tunnel walls as an outer boundary condition to define wall interference. The development, assessment and application of one such method is summarized.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 259-271
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    NLR activities in the field of wind tunnel wall interference (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Measured field data as a boundary condition for calculating the interference flow field were applied. They are divided into two categories. In the first category, the field data must consist of distributions of a single velocity component, and an accurate estimate of the hypothetical free air contribution of the model to this component is required. The differences between measured values and estimated model contributions are attributed to wall interference and they establish the boundary condition. The associated field data measurements are simple, yet the necessary model representation generally is a serious drawback. The second category requires field data which consist of velocity vector distributions at the price of multicomponent measurements, but at the profit that no information at all is required about the model. In solid wall test sections, the price is reduced to virtually zero but the profit remains.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 221-229
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    Performance of two transonic airfoil wind tunnels utilizing limited ventilation (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A limited-zone ventilated wall panel was developed for a closed-wall icing tunnel which permitted correct simulation of transonic flow over model rotor airfoil sections with and without ice accretions. Candidate porous panels were tested in the Ohio State University 6- x 12-inch transonic airfoil tunnel and result in essentially interference-free flow, as evidenced by pressure distributions over a NACA 0012 airfoil for Mach numbers up to 0.75. Application to the NRC 12- x 12-inch icing tunnel showed a similar result, which allowed proper transonic flow simulation in that tunnel over its full speed range.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 165-170
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    Investigations of flow field perturbations induced on slotted transonic-tunnel walls (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The free-stream interference caused by the flow through the slotted walls of the test sections of transonic wind tunnels has continuously a problem in transonic tunnel testing. The adaptive-wall transonic tunnel is designed to actively control the near-wall boundary conditions by sucking or blowing through the wall. In order to make the adaptive-wall concept work, parameters for computational boundary conditions must be known. These parameters must be measured with sufficient accuracy to allow numerical convergence of the flow field computations and must be measured in an inviscid region away from the model that is placed inside the wind tunnel. The near-wall flow field was mapped in detail using a five-port cone probe that was traversed in a plane transverse to the free-stream flow. The initial experiments were made using a single slot and recent measurements used multiple slots, all with the tunnel empty. The projection of the flow field velocity vectors on the transverse plane revealed the presence of a vortex-like flow with vorticity in the free stream. The current research involves the measurement of the flow field above a multislotted system with segmented plenums behind it, in which the flow is controlled through several plenums simultaneously. This system would be used to control a three-dimensional flow field.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 119-142
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    Assessment of lift- and blockage-induced wall interference in a three-dimensional adaptive-wall tunnel (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A three-dimensional adaptive-wall wind tunnel experiment was conducted at Ames Research Center. This experiment demonstrated the effects of wall interference on the upwash distribution on an imaginary surface surrounding a lifting wing. This presentation demonstrates how the interference assessment procedure used in the adaptive-wall experiments to determine the wall adjustments can be used to separately assess lift- and blockage-induced wall interference in a passive-wall wind tunnel. The effects of lift interference on the upwash distribution and on the model lift coefficient are interpreted by a simple horseshoe vortex analysis.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 89-100
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    Wind tunnel wall interference in closed, ventilated and adaptive test sections (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A wall interference correction method for closed rectangular test sections was developed which uses measured wall pressures. Measurements with circular discs for blockage and a rectangular wing as a lift generator in a square closed test section validate this method. These measurements are intended to be a basis of comparison for measurements in the same tunnel using ventilated (in these case, slotted) walls. Using the vortex lattice method and homogeneous boundary conditions, calculations were performed which show sufficiently high pressure levels at the walls for correction purposes in test sections with porous walls. In Gottingen, an adaptive test section (which is a deformable rubber tube of 800 mm diameter) was built and a computer program was developed which is able to find the necessary wall adaptation for interference-free measurements in a single step. To check the program prior to the first run, the vortex lattice method was used to calculate wall pressure distributions in the nonadapted test section as input data for the one-step method. Comparison of the pressure distribution in the adapted test section with free-flight data shows nearly perfect agreement. An extension of the computer program can be made to evaluate the remaining interference corrections.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 61-78
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    Review of the advanced technology airfoil test program in the 0.3-meter transonic cryogenic tunnel (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The following areas were addressed: interchangeable test sections in the 0.3-M Transonic Cryogenic Tunnel (TCT); typical airfoil installation; airfoil capability; advanced technology airfoil test (ATAT); effects of the Reynolds number on the normal force coefficient; effects of the Reynolds number on the drag coefficient; and comparison of experimental results with theory.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 361-374
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  • 65
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    Determination of equivalent model geometry for tunnel wall interference assessment/correction (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A formula for the determination of equivalent model geometry with two variables measured at the interface is derived, based on two dimensional subsonic flow. This predicted model profile is a reasonable initial estimate for transonic flow as long as the sonic region does not reach the interface. A general formula is given in two forms. One is in terms of complex variable functions and the other is an integral equation. The complex-function formula has the advantage of using analytic expressions. The integral equation form requires a numerical solution after assuming the model geometry as a polynomial function. Examples are given to illustrate the application of the formulas.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 335-342
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    Wind tunnel wall interference correction for aircraft models (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Wall interference correction procedures seek to determine the required changes in certain flow or geometric parameters so that the difference between the flow properties at the model's surface in the tunnel and free air are minimized. A transonic and a linear correction procedure were developed for aircraft models. In addition to Mach number and angle of attack corrections, an estimate of the accuracy of the corrections is provided by the transonic correction procedure. Lift, pitching moment and pressure measurements near the tunnel walls are required. The efficiency and accuracy of the correction procedure are improved. Moreover, correction of both the wing and tail angles of attack is allowed. The procedure is valid for transonic as well as subcritical flows. However, for subcritical flows further approximations and simplifying assumptions are made, leading to a very simple and efficient correction procedure.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center. Wind Tunnel Wall Interference Assessment and Correction, 1983; p 301-322
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    Tunnel constraint for a jet in crossflow (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A facet of a unified tunnel correction scheme which uses wall pressures to determine tunnel induced blockage and upwash is described. With this method, there is usually no need to use data concerning model forces or power settings to find the interference; it follows directly from the pressures and tunnel dimensions. However, highly inclined jets do not produce good pressure signatures and are highly three dimensional, so they must be treated differently. Flow modeling is also discussed.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center. Wind Tunnel Wall Interference Assessment and Correction, 1983; p 273-290
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    Progress in wind tunnel wall interference assessment/correction procedures at the NAE (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Wall corrections as a function of wall porosity in the transonic wall interference problem was assessed. Effective porosities primarily for the two dimensional case were established as follows: (1) comparison of experimental data for two geometrically similar models of different chord/height ratio, an overall value of wall porosity could be deduced; (2) theoretical development which allows for unequal porosity for the floor and ceiling and wall boundary pressure measurements, porosities for floor and ceiling could be deduced; (3) a scheme was developed which allowed unequal porosity of floor and ceiling and streamwise varying porosity. The boundary layer development along the perforated floor and ceiling under the influence of the model pressure field, variations in boundary layer thickness underlining the difficulties in deducing meaningful values of wall porosity were determined. Wall boundary pressure measurement, in combination with singularity modelling of the airfoil, was sufficient to yield required information on the wall interference flow without having to establish some value for wall porosity. The singularity modelling of the airfoil initially covered only lift and volume but was extended to include drag and pitching moment, and second order volume term. It is shown by asymptotic transonic small disturbance analysis, that the derived corrections to angle of attack and free stream Mach number are correct to the first order.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 231-257
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  • 69
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    Asymptotic methods for wind tunnel wall corrections at transonic speed (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The effort to develop classical methods to compute wall interference at transonic speeds is outlined. The two-dimensional theory and three-dimensional development are discussed. Also, some numerical application of the two-dimensional work are indicated. The basic advantages of the asymptotic theory are noted.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 193-203
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    Effect of boundary layers on solid walls in three-dimensional subsonic wind tunnels (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A solution for the tunnel wall boundary layer effects for three-dimensional subsonic tunnels is presented. The model potentials are represented with simple singularities placed on the centerline of the tunnel and Laplace's equation in cylindrical coordinates is solved for either the conventional homogeneous slotted-wall boundary condition, the solid-wall viscous boundary condition, or a combination of them. The most pronounced wall boundary layer effect is on solid blockage for completely closed wind tunnels. Boundary layers on the wall reduce the blockage from the solid-wall, no-boundary-layer case in a manner similar to opening slots in a solid wall. Additionally, for solid-wall tunnel configurations, the streamline curvature interference factor is reduced by a significant amount, whereas the lift interference factor at the model station does not depend on the boundary layer parameter. For combination wall configurations, the slot effect of the horizontal walls dominates the viscous effect of the solid sidewalls.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 205-218
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  • 71
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    Experiments suitable for wind tunnel wall interference assessment/correction (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Three experiments suitable for wall interference assessment and evaluation of proposed correction methods are presented. The experiments are: (1) a series of airfoil tests using a newly designed transonic flow facility that employs side-wall boundary layer suction and upper- and lower-wall shaping; (2) tests on a swept airfoil section spanning a solid-wall wind tunnel with fixed contouring on all four walls; and (3) tests on a swept wing of aspect ratio 3 mounted in a solid-wall wind tunnel with fixed flat walls. Each of the experiments provides data on the airfoil sections as well as on the wind tunnel walls. All the experiments were performed in solid wall wind tunnels corrected for boundary layer displacement effects. Although the experiments were performed primarily to evaluate computer code performance, it is believed that they also provide information that can be used to evaluate methods for assessing and correcting wall interference effects.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 171-190
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  • 72
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    Effect of upstream sidewall boundary layer removal on an airfoil test (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Sidewall boundary layer effects were investigated by applying partial upstream sidewall boundary layer removal in the Langley 0.3-m transonic cryogenic tunnel. Over the range of sidewall boundary layer displacement thickness of these tests the influence on pressure distribution was found to be small for subcritical conditions; however, for supercritical conditions the shock position was affected by the sidewall boundary layer. For these tests (with and without boundary layer remove) comparisons with predictions of the GRUMFOIL computer code indicated that Mach number corrections due to the sidewall boundary layer improve the agreement for both subcritical and supercritical conditions. The results also show that sidewall boundary layer removal reduces the magnitude of the sidewall correction; however, a suitable correction must still be made.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 143-163
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  • 73
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    A data base for three-dimensional all-interference code evaluation (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A validation of a measured boundary condition technique was carried out to demonstrate the feasibility of a wall interference assessment/correction (WIAC) system. An experimental evaluation was also carried out to compare performances of various techniques, to define the number of necessary boundary measurements for accurate assessment/corrections and to define the envelope of test conditions for which accurate assessment/corrections are achieved. The relative merits of a WIAC system and an adaptive wall tunnel are compared. The measurement surface boundary data is performed with a system of two rotating pipes. These pipes sweep out a cylindrical measurement surface near the tunnel walls, approximately one inch from the wall at the closest point. The experimental model was specially designed and fabricated for the adaptive wall experiments. The model is a wing/tail/body configuration with swept lifting surface. The boundary data taken in Tunnel 1T with the rotating pipe system has been shown to offer several attractive features for WIAC code evaluation. Good spatial resolution of measurements is achieved and measurements are made upstream and downstream of the model. Also, two velocity components are determined.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 101-118
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    Survey of ONERA activities on adaptive-wall applications and computation of residual corrections (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The research undertaken concerning the computation and/or reduction of wall interference follows two main axes: improvement of wall correction determinations, and use of adaptive flexible walls. The use of wall-measured data to compute interference effects is reliable when the model representation is assessed by signatures with known boundary conditions. When the computed interferences are not easily applicable to correcting the results (especially for gradients in two-dimensional cases), the flexible adaptive walls in operation in T2 are an efficient and assessed means of reducing the boundary effects to a negligible level, if the direction and speed of the flow are accurately measured on the boundary. The extension of the use of adaptive walls to three-dimensional cases may be attempted since the residual corrections are assumed to be small and are computable.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 43-60
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  • 75
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    Remarks on future developments (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-12
    Description: Future developments in satellite meteorology are proposed and examined in the light of policy and funding changes.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 97-101
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    Prospects for the future (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: Atmospheric and surface fields produced from the TIROS N high resolution infrared sounder/microwave sounding unit data are discussed. The data were analyzed by direct physical inversion of the multispectral radiative transfer equation. Sea ice mapping and sea surface temperature determination are addressed.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 84-96
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  • 77
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    Key scientific questions and the role of satellites (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: Some of the research opportunities that are available from geostationary satellite data, especially from MONEX during the Global Weather Experiment are described. In addition, the International Cloud Climatology Program is described and the use of satellite imagery in studying mesoscale convection complexes is discussed. Finally, information derived from satellite data on ocean winds is examined.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Marshall Space Flight Center The Conception, Growth, Accomplishments and Future of Meteorol. Satellites; p 48-71
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    Volcanoes and climate (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: The evidence that volcanic eruptions affect climate is reviewed. Single explosive volcanic eruptions cool the surface by about 0.3 C and warm the stratosphere by several degrees. Although these changes are of small magnitude, there have been several years in which these hemispheric average temperature changes were accompanied by severely abnormal weather. An example is 1816, the "year without summer" which followed the 1815 eruption of Tambora. In addition to statistical correlations between volcanoes and climate, a good theoretical understanding exists. The magnitude of the climatic changes anticipated following volcanic explosions agrees well with the observations. Volcanoes affect climate because volcanic particles in the atmosphere upset the balance between solar energy absorbed by the Earth and infrared energy emitted by the Earth. These interactions can be observed. The most important ejecta from volcanoes is not volcanic ash but sulfur dioxide which converts into sulfuric acid droplets in the stratosphere. For an eruption with its explosive magnitude, Mount St. Helens injected surprisingly little sulfur into the stratosphere. The amount of sulfuric acid formed is much smaller than that observed following significant eruptions and is too small to create major climatic shifts. However, the Mount St. Helens eruption has provided an opportunity to measure many properties of volcanic debris not previously measured and has therefore been of significant value in improving our knowledge of the relations between volcanic activity and climate.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 15-36
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  • 79
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    Viscous wing code development: A 3-D viscid-inviscid interactive analysis (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 2; p 607-63
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  • 80
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    Computation of separated flow on airfoils with the Grumfoil code (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 2; p 557-58
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  • 81
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    Analysis of airfoil transitional separation bubbles (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 2; p 539-55
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  • 82
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    Entropy effects and shock fitting in conical supersonic full potential flows (1983)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center, Theoretical Aerodynamics Contractors' Workshop, Volume 2; p 461-49
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  • 83
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    Viscous transonic flow computation over Space Shuttle configuration (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: A thin-layer Navier-Stokes code capable of predicting steady-state viscous flows is applied to the transonic flow over a Space Shuttle configuration. The code is written in the generalized coordinate system, and the grid-generation code of Fujii (1983) is used for the discretization of the flow field. The flow-field computation is done using the CRAY 1S computer at NASA Ames. The computed result is physically reasonable, even though no experimental data is available for the comparison purpose.
    Keywords: AERODYNAMICS
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    Some aspects of understanding changes in the global carbon cycle (1984)
    In:  Other Sources
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    Publication Date: 2011-08-19
    Description: The collective character of carbon exchanges between the atmosphere and other pools is partially revealed by comparing the record of CO2 concentration beginning in 1958 with estimates of the releases from fossil fuels during this period. In analyzing the secular increase in CO2 concentration induced by fossil fuel use, the atmosphere is generally treated as a single well-mixed reservoir; however, to study finer structure in the CO2 records, the influence of atmospheric circulation must be more carefully considered. The rate of carbon uptake by the oceans, the primary sink for fossil fuel CO2, is assessed more reliably than influences on the atmosphere due to interactions with other pools. Models of the global carbon cycle are being substantially refined while data that reflect the response of the cycle to fossil fuel use and other perturbations are being extended.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: JPL The interaction of Global Biochemical Cycles; p 55-84
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  • 85
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    A statistical correlation method for the retrieval of atmospheric moisture profiles by microwave radiometry (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: A statistical correlation technique is applied to the retrieval of vertical moisture profiles under clear-sky conditions from down-looking radiometric measurements of atmospheric radiation at microwave wavelengths. For a given set of channels, the method selects the optimum radiometric channels for estimating water vapor at specific pressure levels between the surface and 300 mb. The water vapor mixing ratio at these pressure levels is then calculated from a linear combination of the selected channel brightness temperatures. To test its validity the algorithm was applied, in a numerical experiment, to fifty independent tropical radiosondes. The rms absolute deviation of the estimated moisture profiles from the actual profiles was comparable to that obtained using an iterative retrieval method reported earlier. The statistical method, however, requires several orders of magnitude less computer time than the iterative method; it is suitable for high speed processing of large amounts of data.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Journal of Climate and Applied Meteorology (ISSN 0733-3021); 23; 1110-111
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  • 86
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    Nonlinear aerodynamic effects on bodies in supersonic flow (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 21; 809-815
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  • 87
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    Problems in simulating the stratocumulus-topped boundary layer with a third-order closure model (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: The Andre et al. (1976, 1978) third-order closure model, in which the time rate of change terms, the relaxation and rapid effects for pressure-related terms, and the clipping approximation are used along with the quasi-normal closure, is invoked in the study of turbulence in a cloudy layer that is radiatively cooled from above. A spurious oscillation whose greatest amplitude lies near the inversion is shown by analysis to arise from the mean gradient and buoyancy terms of the triple-moment equations. An attempt is made to damp the oscillation through the introduction of diffusion terms into the triple-moment equations. The results obtained are noted to be sensitive to the ad hoc eddy coefficient applied in the third-moment equations.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Journal of the Atmospheric Sciences (ISSN 0022-4928); 41; 1588-160
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  • 88
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    New implicit boundary procedures - Theory and applications (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: Previously cited in issue 5, p. 579, Accession no. A83-16536
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 22; 1094-110
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  • 89
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    Numerical simulations of unsteady transonic flow in diffusers (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: Previously cited in issue 15, p. 2346, Accession no. A82-31959
    Keywords: AERODYNAMICS
    Type: AIAA Journal (ISSN 0001-1452); 22; 1139-114
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  • 90
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    Effects of viscosity on transonic-aerodynamic and aeroelastic characteristics of oscillating airfoils (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 21; 700-707
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  • 91
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    Leeside flows over delta wings at supersonic speeds (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 21; 680-686
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  • 92
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    Lightning activity and severe storm structure (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: Space-time mapping of VHF sources from four severe storms on June 19, 1980 reveals that lightning processes for cloud-to-ground (CG) and large intracloud (IC) flashes are confined to an altitude below about 10 km and closely associated with the central regions of high reflectivity. Another class of IC flashes produces a splattering of sources within the storms' main electrically active volumes and also within the large divergent wind canopy aloft. There is no apparent temporal association between the small high altitude IC flashes that occur almost continuously and the large IC and CG flashes that occur sporadically in the lower portions of storms.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Geophysical Research Letters (ISSN 0094-8276); 11; 545-548
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    A variational formulation for time-dependent climate models (1984)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: A variational principle for time dependent diffusion problems is presented and is demonstrated by applying it to simple seasonal climate models. Two cases are treated. The first, a North-Coakley-type model with constant properties, is used as a tutorial example for the application of the technique. For the second case, heat capacity and thermal conductivity are considered to be latitude dependent in order to treat the effects of land/ocean distribution on the seasonal temperature distribution over the earth. The variational equations are derived and approximate analytical solutions are developed which delineate the influences of the physical asymmetries of the hemispheres in producing an asymmetric annual cycle.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Journal of Geophysical Research (ISSN 0148-0227); 89; 2601-260
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    Analogs in the wintertime 500 mb height field (1984)
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    Publication Date: 2011-08-18
    Description: Lorenz (1969) has considered the possibility that an atmospheric circulation pattern might recur, taking into account the definition of a pair of analogous flows or 'analogs'. The present investigation is concerned with a search of time series of Northern Hemisphere wintertime geopotential heights for possible analogs. Attention is given to data and analysis procedure, analog quality, and error growth rates. The obtained results imply that the found analogs are not a useful tool for forecasting the evolution of the midlatitude flow on time scales of several days. It is pointed out, however, that the negative results should not be extended to other applications of analog forecasting.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Journal of the Atmospheric Sciences (ISSN 0022-4928); 41; 177-189
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  • 95
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    Fresh attack on laminar flow (1984)
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    Publication Date: 2011-08-18
    Description: Laminar flow control is a technology with great potential for aircraft drag reduction. Stabilization of laminar boundary layers became known as natural laminar flow (NLF) and research led to the development of NLF airfoils. Research was also conducted on stabilization by suction, referred to as laminar flow control (LFC). Experiments demonstrated that extensive laminar flow could be achieved in flight. However, there remained doubts regarding the practicality of producing, with the technology then available, wing surfaces sufficiently smooth and wavefree to meet laminar-flow criteria and maintaining the wing surface quality in normal service. In 1976, the Aircraft Energy Efficiency (ACEE) program was begun by NASA to develop fuel-conservative technology for commercial transports. The progress of the ACEE program is discussed. Attention is given to LFC wing structures, and LFC leading-edge systems.
    Keywords: AERODYNAMICS
    Type: Aerospace America (ISSN 0740-722X); 22; 72-76
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  • 96
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    Space Shuttle heating analysis with variation in angle of attack and catalycity (1984)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Previously cited in issue 5, p. 586, Accession no. A83-16747
    Keywords: AERODYNAMICS
    Type: Journal of Spacecraft and Rockets (ISSN 0022-4560); 21; 217-219
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    A case study of the sensitivity of forecast skill to data and data analysis techniques (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: A series of experiments have been conducted to examine the sensitivity of forecast skill to various data and data analysis techniques for the 0000 GMT case of January 21, 1979. These include the individual components of the FGGE observing system, the temperatures obtained with different satellite retrieval methods, and the method of vertical interpolation between the mandatory pressure analysis levels and the model sigma levels. It is found that NESS TIROS-N infrared retrievals seriously degrade a rawinsonde-only analysis over land, resulting in a poorer forecast over North America. Less degradation in the 72-hr forecast skill at sea level and some improvement at 500 mb is noted, relative to the control with TIROS-N retrievals produced with a physical inversion method which utilizes a 6-hr forecast first guess. NESS VTPR oceanic retrievals lead to an improved forecast over North America when added to the control.
    Keywords: METEOROLOGY AND CLIMATOLOGY
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  • 98
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    Effect of high latitude filtering on NWP skill (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: An assessment is made of the extent to which polar filtering may seriously affect the skill of latitude-longitude NWP models, such as the U.S. Navy's NOGAPS, or the GLAS fourth-order model. The limited experiments which have been completed to date with the 4 x 5-deg, 9-level version of the latter model indicate that the high latitude filter currently in operation affects its forecasting skill very little, with only one exception in which the use of the PG filter significantly improved forecasting.
    Keywords: METEOROLOGY AND CLIMATOLOGY
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    Thunderstorm cloud top observations using satellite stereoscopy (1983)
    In:  Other Sources
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    Publication Date: 2011-08-18
    Description: The present investigation has as objective to take a detailed look at the intense squall line over Oklahoma on May 2-3, 1979, using GOES stereoscopy combined with GOES infrared data. The synoptic situation and data sources are considered along with the stereoscopically observed cloud top ascent rates. Cloud top observations of intense thunderstorms are discussed, taking into account a contouring technique, the interpretation of infrared cloud top temperature patterns, and small-scale structure and its variability. It is found that GOES IR cloud top temperatures grossly underestimate the actual cloud top height observed stereoscopically, especially for immature storms. It is difficult to define growing storms below about 10 km in the GOES infrared data.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Monthly Weather Review (ISSN 0027-0644); 111; 1949-196
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    Highlights of the Symposium on the Multiple-Parameter Radar Measurements of Precipitation - Personal reflections. (1984)
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    Publication Date: 2011-08-18
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Radio Science (ISSN 0048-6604); 19; 238-242
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