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  • Lepidoptera  (31)
  • bioavailability  (25)
  • Springer  (56)
  • International Union of Crystallography
  • 1980-1984  (56)
  • 1940-1944
  • 1981  (56)
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Keywords
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  • Springer  (56)
  • International Union of Crystallography
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  • 1980-1984  (56)
  • 1940-1944
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  • 1
    Electronic Resource
    Electronic Resource
    The effect of variation in host plant on the growth of an oligophagous insect, Malacosoma americanum and its polyphagous relative, Malacosoma disstria (1981)
    Springer
    Entomologia experimentalis et applicata 30 (1981), S. 163-168 
    Details
    ISSN: 1570-7458
    Keywords: host-plant relations ; host variation ; Malacosoma americanum ; Malacosoma disstria ; Lasiocampidae ; Geometridae ; Lepidoptera ; niche breadth ; specialization ; plantinsect interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Raupen von Malacosoma americanum (F.), einer oligophagen Art, die sich vor allem auf Prunus und andern baumartigen Rosaceen entwickelt, wurden verglichen mit Raupen der polyphageren Verwandten M. disstria Hb. und zwar im Hinblick auf deren Empfindlichkeit auf Unterschiede im Blatt ihrer gemeinsamen Wirtspflanze, Prunus serotina Ehrh. Das Puppengewicht und die Entwicklungszeit bis zur Verpuppung wurden gemessen bei Raupen, welche auf Blättern von freiwachsenden und von beschatteten Jungpflanzen gezüchtet worden waren. Die Blattunterschiede hatten eine ausgesprochene Wirkung, aber es gab keine Unterschiede in der Reaktion der beiden Arten. Dieser Vergleich lässt vermuten, dass die Empfindlichkeit auf intraspezifische Unterschiede der Wirtspflanzenqualität bei wirtsspezifischen und polyphagen Arten gleich ist. Indessen dürften sich laut anderen Resultaten einige Insektenarten anders verhalten.
    Notes: Abstract Larvae of Malacosoma americanum (F.)(Lepidoptera: Lasiocampidae) an oligophagous species that feeds primarily on Prunus and other rosaceous trees, were compared to larvae of the more highly polyphagous congener M. disstria Hb., with respect to their sensitivity to variation in the foliage of a common host plant, Prunus serotina Ehrh. Pupal weight and time to pupation were measured on larvae reared on foliage from open-grown and from shaded saplings. The difference in foliage had a pronounced effect, but no difference was evident between the species in their response to the variation in foliage. This comparison implies that sensitivity to intraspecific variation in host quality does not differ between host-specific and generalized species. However, results from other species suggest that some species of insects do differ in this respect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300882
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  • 2
    Electronic Resource
    Electronic Resource
    Food plant specialization and feeding efficiency in the tent caterpillars Malacosoma disstria and M. americanum (1981)
    Springer
    Entomologia experimentalis et applicata 30 (1981), S. 106-110 
    Details
    ISSN: 1570-7458
    Keywords: assimilation efficiency ; growth efficiency ; niche breadth ; specialization ; hostplant relations ; plant-insect interactions ; Malacosoma americanum ; Malacosoma disstria ; Lasiocampidae ; Lepidoptera
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Raupen von Malacosoma americanum, einer oligophagen Art, die sich vor allem auf Prunus und andern baumartigen Rosaceen. entwickelt, wurden mit Raupen der polyphageren Verwandten M. disstria in Hinblick auf die Verwertung der Blätter ihres gemeinsames Wirtes Prunus serotina verglichen. Wirerhielten ähnliche Werte wie sie früher für andere Lepidopteren publiziert worden waren und zwar in Bezug auf die üblichen Messwerte, Anteil verwertete Nahrung, Wachstum in Trockengewicht pro Einheit gefressene oder verwertete Nahrung. Zudem unterschieden sich die beiden Arten in keiner Masszahl für Effizienz. Unsere Resultate sind im Einklang mit der Folgerung, das spezialisierte phytophage Insekten ihre Wirtspflanzen nicht besser ausnützen als as polyphage Arten tun.
    Notes: Abstract Larvae of Malacosoma americanum (F.) an oligophagous species that feeds primarily on Prunus and other rosaceous trees, were compared to larvae of the more highly polyphagous congener M. disstria Hb., with respect to the efficiency of utilization of the foliage of a common host plant, Prunus serotina Ehrh. We obtained values similar to those reported for other Lepidoptera for the commonly used measures of the fraction of ingested food that was assimilated, and for the growth in dry weight per unit of food ingested or assimilated. Moreover, the two species did not differ in any measure of efficiency. Our results are compatible with the conclusion that specialized phytophagous insects do not use their host plants with greater physiological efficiency than do generalized insects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300873
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  • 3
    Electronic Resource
    Electronic Resource
    Host races and sympatric speciation in small ermine moths, Yponomeutidae (1981)
    Springer
    Entomologia experimentalis et applicata 30 (1981), S. 280-292 
    Details
    ISSN: 1570-7458
    Keywords: Allozyme variation ; Lepidoptera ; Yponomeuta padellus ; evolutionary stages ; F-statistics ; panmixis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Le degré de différenciation génétique en allozymes à des niveaux divers de divergence évolutive (populations conspécifiques, sibling species et non-sibling species) d'Yponomeuta a été déterminé. Les distances génétiques entre des sibling species ou des non-sibling species sont très larges. Il en est conclu que de telles estimations ne fournissent pas beaucoup d'informations sur le phénomène de spéciation même. Des coéfficients de reproduction consanguine (F ST) ont été calculés pour des populations d'Y. padellus provenant de six plantes-hôtes. La valeur moyenne F STest .030±.012. Les valuers de F ST des populations recueillies sur Crataegus, (plante-hôte habituelle d'Y. padellus), sont inférieures 2–3.5 fois à celles des populations de l'ensemble des autres plantes-hôtes. L'apparition de races en fonction de l'hôte, mesurée par les différences importantes dans de fréquences des allozymes entre populations sympatriques sur plusieurs plantes-hôtes, a été examinée dans quatre régions. Il apparaît ainsi que la formation de races en fonction de l'hôte se produit chez Y. padellus et que la spéciation sympatrique est un évènement très vraisemblable.
    Notes: Abstract The amount of genetic differentiation at various levels of evolutionary divergence (conspecific populations, sibling species and non-sibling species) in Yponomeuta was determined. Genetic distances between siblings or non-siblings were found to cover a wide range. It is concluded that such estimates do not give much information on the speciation process itself. Inbreeding coefficients were calculated for populations of Y. padellus from a total of six host plants. The grand mean F ST value is 0.030±0.012. F ST values for populations sampled from Crataegus, the common food plant of Y. padellus, are 2–3.5 times smaller than those for populations from the other food plants taken together. Host race formation, as measured by significant differences in allozyme frequencies between sympatric populations on two or more food plants, was investigated in four areas. Host race formation seems to occur in Y. padellus and sympatric speciation is a likely event.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347708
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  • 4
    Electronic Resource
    Electronic Resource
    Repellency of pheromones released by females of Heliothis armigera and H. zea to females of both species (1981)
    Springer
    Entomologia experimentalis et applicata 30 (1981), S. 123-127 
    Details
    ISSN: 1570-7458
    Keywords: Sex Pheromones ; Repellent ; Heliothis armigera ; Heliothis zea ; Lepidoptera ; Noctuidae ; cotton bollworm ; corn earworm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé L'examen en olfactomètre a porté sur les réactions face à d'autres femelles de la même espèce, de femelles vierges ou ayant copulé d'Heliothis armigera Hübner et H. zea Boddie. Le lot comprenait 8 femelles, vierges ou ayant copulé en présence d'une femelle vierge ou ayant copulé. Les 4 combinaisons possibles de femelles vierges et de femelles ayant copulé ont été examinées avec 12 répétitions pour chaque espèce. Un extrait de l'extrémité de l'abdomen de femelles vierges d'une espèce a été présenté aux femelles de l'autre espèce pour examiner les possibilités de réactions interspécifiques aux phéromones. Pour chaque espèce, les réactions interspécifiques de répulsion entre femelles ont été hautement significatives par rapport aux témoins, à l'exception toutefois des réactions de femelle ayant copulé face à des femelles ayant elles aussi copulé. Les répulsions moyennes chez H. armigera et H. zea pour les 8 femelles de chaque expérience ont été: a) vierges en présence d'une vierge: 7,33 et 7,66; b) vierges en présence d'une femelles ayant copulé: 5,76 et 5,58; c) femelles ayant copulé en présence d'une vierge: 4,67 et 4,83. Les différences sont hautement significatives entre chaque paire de moyennes et entre chaque paire et le lot témoin; 3,17; 3,17; 3,42; 4,00 pour H. armigera; 3,17; 3,50; 2,83 et 3,75 pour H. zea. Les femelles vierges des deux espèces, H. armigera et H. zea ont présenté une réaction de répulsion en présence d'un extrait de l'abdomen de l'autre espèce; les répulsions moyennes étant respectivement 5,53 et 5,33 contre 3,83 et 3,58 pour le lot trémoin. On peut en conclure que ces répulsions doivent entraîner une tendance à la répartition uniforme.
    Notes: Abstract An olfactometer was used to determine the effect of pheromones released by females of the bollworms Heliothis armigera (Hübner) and H. zea (Boddie) on females of the same species. Four combinations of virgin and mated females were tested for repellency of one to the other. Evidence is presented that females of the two bollworms were repelled by females of the same species. In addition, extracts of virgin female abdomens of each species repelled virgin females of the other species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300876
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of medigoxin in outpatients (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 251-258 
    Details
    ISSN: 1432-1041
    Keywords: medigoxin ; digoxin ; dissolution rate ; proportionality ; bioavailability ; prediction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We compared our ability to predict the dose of medigoxin and of digoxin required to achieve a fixed serum concentration (the dose requirement) in 33 outpatients. Preliminary work supported the assumptions that the steady state glycoside concentration achieved was proportional to the daily dose given to an individual, and that the bioavailability of the different tablet presentations was similar for either glycoside. We were not able to predict the dose requirement from patient characteristics with any more certainty for medigoxin than for digoxin. Not only the between-patient variability in dose requirement, but also the within-patient variability, was similar for the two glycosides. However the digoxin used had a dissolution rate of over 90% in 1 h. When comparing medigoxin with digoxin of lower, or more variable dissolution rate, medigoxin may be preferable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562801
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of dose on bioavailability of oral digoxin (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 53-55 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; bioavailability ; dose-dependency ; urinary excretion ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nine healthy volunteers received single 0.25, 0.5, 1.0, 1.5, and 2.0 mg doses of oral digoxin tablets in random sequence on five occasions separated by at least 4 weeks. Urinary excretion of immunoassayable digoxin was determined from 8 consecutive 24 h urine samples collected after each dose. Mean values of cumulative urinary excretion of digoxin at the 5 doses were: 40.9, 35.6, 36.4, 34.1, and 33.5% of the dose (F=0.64; d. f.=4.32; N. S.). Mean values of urinary excretion half-life were: 2.48, 2.03, 2.20, 2.07, and 1.87 days (F=2.87; d. f.=4.32;p=0.05). Thus, the bioavailability of orally administered digoxin tablets in healthy volunteers is dose-independent over an 8-fold range of doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558384
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and bioavailability of diacetolol, the main metabolite of acebutolol (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 287-292 
    Details
    ISSN: 1432-1041
    Keywords: diacetolol ; acebutolol ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and bioavailability of diacetolol, the principal metabolite of acebutolol, were studied in 6 healthy subjects. Plasma concentrations were determined following a single intravenous injection of diacetolol 100 mg and three oral doses of diacetolol 100, 400 and 800 mg, in random order. The average oral bioavailability of diacetolol was F: 0.302±0.052 (100 mg), 0.363±0.052 (400 mg) and 0.426±0.068 (800 mg); the differences are not significant. The mean plasma half-life of the terminal phase, 7.94±0.26 h after intravenous administration, was significantly higher than after oral administration 12.27±1.00 h (100 mg), 12.82±1.59 h (400 mg) and 13.05±1.22 h (800 mg) (p〈0.02 to 0.05); the mean urine half-lives of the terminal phase were not significantly different. Renal clearance of diacetolol 10.2±0.81·h−1 represented about two-thirds of total body clearance 15.9±1.21·h−1. The results suggest either a first-pass effect or incomplete absorption of diacetolol after oral administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562806
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  • 8
    Electronic Resource
    Electronic Resource
    Bioavailability of ketoprofen in man with and without concomitant administration of aluminium phosphate (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 305-307 
    Details
    ISSN: 1432-1041
    Keywords: ketoprofen ; aluminium phosphate ; bioavailability ; antacid ; pharmacokinetics ; interaction study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The purpose of this study was to determine whether a concomitant single dose of antacid (aluminium phosphate), or multiple doses of this antacid, administered prior to and with ketoprofen would alter the bioavailability of this non steroidal anti-inflammatory agent. The possible effects of aluminium phosphate were evaluated following administration of ketoprofen alone (Phase I), co-administration of antacid and ketoprofen (Phase II), and antacid for four days before administration of ketoprofen with co-administration on the day of the study (Phase III). There were no significant differences between treatment means for peak plasma concentration, time to peak plasma concentration, and area under the plasma concentration-time curve. The observed differences were due only to individual effects. The results indicate a lack of interaction between ketoprofen and the antacid aluminium phosphate (Phosphalugel)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562809
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  • 9
    Electronic Resource
    Electronic Resource
    Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 359-365 
    Details
    ISSN: 1432-1041
    Keywords: tolfenamic acid ; anti-inflammatory agent ; human pharmacokinetics ; bioavailability ; intravenous administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent was studied in six healthy volunteers after an intravenous dose of 100 mg and oral doses of 100, 200, 400 and 800 mg. The disposition of intravenous tolfenamic acid could be described by two-compartment open model, with a central compartment volume (Vdc) of 5.6±0.31 (mean±SE), volume during β-phase (Vdβ) of 31±21, and a total elimination rate constant (k10) 1.6±0.1 h−1. The terminal elimination half-life was 2.5±0.6 h and the total plasma clearance 155±15 ml/min. The elimination occured principally by extrarenal mechanisms, the recovery of unchanged drug together with is glucuronide in urine averaging only 8.8% of the intravenous dose. The binding of tolfenamic acid to plasma proteins averaged 99.7%. The gastrointestinal absorption had a mean half-life of 1.7±0.1 h. Based on comparison of areas under the plasma concentration time-curves after intravenous and oral administration, the biovailability of tolfenamic acid capsules averaged 60%. The rate and extent of absorption and the rate of elimination of tolfenamic acid were independent of dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544587
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  • 10
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and bioavailability of tranexamic acid (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 65-72 
    Details
    ISSN: 1432-1041
    Keywords: tranexamic acid ; pharmacokinetics ; bioavailability ; oral absorption ; influence of food ; plasma clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Tranexamic acid 1 g was given intravenously to three healthy volunteers. Plasma concentrations decayed in three monoexponential phases. Most elimination took place during the first eight hours, giving an apparent elimination half-life of approximately two hours. Plasma clearance ranged between 110–116 ml/min. The urinary recovery of tranexamic acid exceeded 95% of the dose. Ten healthy volunteers were given tranexamic acid 2 g orally on an empty stomach, and together with a meal. Food had no influence on the absorption of tranexamic acid, as judged by comparison of the peak plasma concentration, the time required to reach the peak, the AUC from zero to six hours, and the urinary excretion data. The oral bioavailability of tranexamic acid, calculated from 24 h urinary excretion after oral and intravenous administration, was 34% of the dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554669
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  • 11
    Electronic Resource
    Electronic Resource
    A comparison of the bioavailability and potency of dexamethasone phosphate and sulphate in man (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 277-282 
    Details
    ISSN: 1432-1041
    Keywords: dexamethasone phosphate ; dexamethasone sulphate ; intravenous injection ; bioavailability ; pituitary-adreno-cortical suppression ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolic fate and ACTH-supressant activity of two injectable dexamethasone esters, 21-phosphate and 21-sulphate, were studied in healthy men. After i.v. injection of 20 mg free steroid alcohol, dexamethasone phosphate was efficiently hydrolyzed to free dexamethasone, reaching its peak plasma concentration within 5 min. About 9% of the administered dose appeared in the urine as free dexamethasone. By contrast, virtually no free dexamethasone was found in plasma and urine after injection of dexamethasone sulphate. Pharmacokinetic analysis showed that dexamethasone sulphate had a shorter plasma half-life and a higher metabolic clearance rate than free dexamethasone. A larger fraction (60%) of dexamethasone sulphate was rapidly excreted unmetabolized in urine. The plasma cortisol level was significantly suppressed for more than 24 h after dexamethasone phosphate, while the plasma cortisol profile after dexamethasone sulphate merely showed physiological circadian variations. When the steroid esters were injected after pretreatment with metyrapone, a definite suppression of plasma ACTH was noted after dexamethasone phosphate, but again, dexamethasone sulphate was ineffective. These results cast serious doubt on the clinical value of dexamethasone sulphate as an injectable glucocorticoid, and critical reevaluation of this preparation is needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00618778
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  • 12
    Electronic Resource
    Electronic Resource
    Single-dose pharmacokinetics of metoclopramide (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 465-471 
    Details
    ISSN: 1432-1041
    Keywords: metoclopramide ; pharmacokinetics ; bioavailability ; first-pass effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time courses of plasma metoclopramide concentrations were followed in six subjects after oral and intravenous single dose administration. Plasma concentration-time data following i.v. administration in each subject were found to fit a two compartment model with a mean terminal half-life of 4.55 h±0.80 h and a mean distribution half-time of 0.35 h±0.09 h. Volumes of distribution were high (3.43±1.181 · kg−1), and clearances (0.53±0.191 · kg−1h−1) approached liver plasma flow. This suggests that metoclopramide occurs at higher concentrations in tissues than in plasma, and that its clearance is probably limited by liver blood flow rather than liver metabolic capacity. The post-absorption decline in metoclopramide plasma levels after oral administration was also biexponential in each subject. The terminal half-life was 5.17 h±0.98 h. Mean volume of distribution and mean clearance were similar to intravenous values (after adjustment for bioavailability). Oral absorption was rapid with peak plasma concentrations being reached at a mean time of 0.93 h. A mean bioavailability of 0.77 was calculated for the six subjects, and it was postulated that this incomplete availability is due to a first-pass effect. The inter-individual variation in the degree of ‘first-pass’ was considerable (0.47–1.14).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542101
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  • 13
    Electronic Resource
    Electronic Resource
    Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 473-478 
    Details
    ISSN: 1432-1041
    Keywords: methadone ; bioavailability ; pharmacokinetics ; single dose ; stable isotope technique ; two compartment model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition of methadone was studied in eight opiate dependent subjects during detoxification. Plasma concentrations were determined by mass fragmentography for 48 hours after administration of methadone 20 mg as tablets and simultaneous intravenous injection of deuterium-labelled methadone 20 mg. Pharmacokinetic parameters were calculated for the intravenous dose assuming a two compartment open model. Bioavailability was determined by comparing the areas under the plasma concentration versus time curves of unlabelled and labelled methadone. The beta-phase plasma half-lives varied five-fold, with a range from 8.5 to 47 h. The apparent volumes of distribution varied from 2.1 to 5.61/kg. Five patients had a bioavailability exceeding 90%, and three had lower bioavailabilities of between 41 and 76%. The unlabelled and labelled drug appeared to be pharmacokinetically equivalent. The data show that for a majority of these subjects the bioavailability was higher than 45%, the previously reported value. The marked individual variation in methadone pharmacodynamics and kinetics, and the possibilities both of cellular and methabolic tolerance, require an individually optimized dosage regimen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542102
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  • 14
    Electronic Resource
    Electronic Resource
    Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 133-137 
    Details
    ISSN: 1432-1041
    Keywords: verapamil ; pharmacokinetics ; bioavailability ; hepatic first-pass metabolism ; stable isotopes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Following i. v. administration, the plasma concentration-time curve of verapamil could best be described by either a mono- or biexponential equation. Total plasma clearance (1.26 l/min) approached liver blood flow (1.5 l/min), so it can be concluded that its clearance is liver blood flow-dependent. Although absorption was almost complete after oral administration, absolute bioavailability (20%) was low, due to extensive hepatic first-pass metabolism. The approach using stable isotope-labelled and unlabelled drug permits simultaneous administration by the intravascular and extravascular routes, thus allowing determination of absolute bioavailability in a single experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568400
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  • 15
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of proxyphylline in adults after intravenous and oral administration (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 149-155 
    Details
    ISSN: 1432-1041
    Keywords: proxyphylline ; asthma ; pharmacokinetics ; bioavailability ; healthy adults ; theophylline derivative
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum concentrations and urinary excretion of proxyphylline have been measured in five healthy adults after intravenous (29 µmol/kg), single oral (21 µmol/kg) and multiple oral (21 µmol/kg three times a day) doses to produce steady state. The mean peak time after oral administration was 29 min. The mean fraction absorbed was 1.09 calculated from serum concentrations, and 1.05 calculated from urinary excretion of the drug. The apparent volume of distribution was 0.61 l/kg (0.53–0.72 l/kg), 26% higher in males than in females. A two-compartment open model was found to describe the decline in the serum concentrations, giving a mean distribution half-life of 6 min. The intersubject ranges of biological half-life were 8.1–12.1 h and 8.3–12.6 h calculated from serum and urine data, respectively. 24% (18–29%) of the dose was excreted unchanged in urine, which agreed with the relationship between the calculated total body clearance and the renal clearance of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568402
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  • 16
    Electronic Resource
    Electronic Resource
    Influence of phenobarbital treatment on cimetidine kinetics (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 343-347 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; phenobarbital ; gastro-intestinal absorption ; bioavailability ; renal clearance ; non-renal clearance ; enzyme induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of orally administered cimetidine was studied in 8 healthy subjects before and after 3 weeks of treatment with phenobarbital 100 mg daily, and in a separate study 4 subjects received cimetidine intravenously before and after the administration of phenobarbital. There was no change in the volume of distribution, but total plasma clearance was increased by a mean of 18%, mainly due to a 37% increase in nonrenal clearance. Renal clearance and half-life were not significantly altered. The area under the plasma concentration-time curve after oral administration was significantly (P≪0.05) reduced by a mean of 15% after phenobarbital treatment. The amount of cimetidine excreted in urine and its sulphoxide metabolite were significantly (P〈0.05) reduced, on average by 34% and 26%, respectively by phenobarbital treatment. The data indicate that an apparent 20% reduction in the absorption of cimetidine was due to induction of gastrointestinal metabolism of cimetidine, with some contribution also from hepatic metabolism. Reduced absorption per se could not be totally excluded. Although the magnitude of the change was small, the finding of an 11% decrease in the time to achieve an effective plasma level of cimetidine after phenobarbital treatment may contribute to the ineffectiveness of cimetidine in certain patients.
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    URL: http://dx.doi.org/10.1007/BF00544584
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    Serum theophylline levels after use of an anhydrous crystalline theophylline suppository (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 449-452 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; ethylenediamine ; suppository ; serum concentration ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absorption of theophylline from a suppository not containing ethylenediamine was tested in 9 healthy volunteers. AUC after rectal administration of anhydrous crystalline theophylline 250 mg (AUCrectal) was compared with the AUC after oral administration of microcrystalline theophylline 250 mg (Nuelin®; AUCoral) in a randomized, cross-over study. The ratio AUCrectal/AUCoral was 0.75 at 10 h, and the ratio AUCrectal×βrectal/AUCoral×βoral extrapolated to infinite time was 0.83. A mean concentration of 5.7 µg/ml was reached 3.7 h after a single rectal dose. The absorption studies were performed with suppositories stored for 15 weeks at 22 °C. No effect on the in vitro release rate of theophylline from the suppository was observed during storage at room temperature from 3 to 31 weeks after production. Since aminophylline suppositories are known to decompose upon storage, the results suggest that a formulation without ethylenediamine is preferable for the rectal administration of theophylline.
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    URL: http://dx.doi.org/10.1007/BF00542098
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    The clinical pharmacokinetics of buflomedil in normal subjects after intravenous and oral administration (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 459-463 
    Details
    ISSN: 1432-1041
    Keywords: buflomedil ; vasodilatation ; pharmacokinetics ; bioavailability ; vasoactive drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A dose-ranging pharmacokinetic study of buflomedil was carried out in eight subjects to determine the pharmacokinetic parameters of the drug after oral and intravenous administration. Based on AUC∞ analyses, the pharmacokinetics of buflomedil were found to be linear within the dose ranges studied (50 to 200 mg for i. v. injection and 150 to 450 mg for oral administration). In the oral study, the mean biological half-life of the drug was 2.97 h, while after intravenous dose it was 3.25 h. The apparent volume of distribution after the pseudodistribution equilibrium (Fdβ) and volume of distribution at the steady state (Vdss) were 1.43±0.24 l/kg and 1.32±0.26 l/kg, respectively. The mean urinary recovery of intact drug and the metabolite, paradesmethyl buflomedil, after intravenous dosing, were 23.6% and 18.7%, respectively, while after oral dosing, they were 18% and 14.8%, respectively. On the average, 72% of the dose was obserbed into the systemic circulation after oral administration. This level of bioavailability was attributed to the hepatic first-pass effect.
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    URL: http://dx.doi.org/10.1007/BF00542100
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  • 19
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    In vitro release and in vivo serum fluoride levels and urinary excretion after different sodium fluoride tablets (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 225-230 
    Details
    ISSN: 1432-1041
    Keywords: fluoride ; sustained release tablets ; serum concentration ; urinary excretion ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Various sodium fluoride tablets used for the treatment of osteoporosis were evaluated. The tablets were characterized in vitro by determining the release curves. The serum levels and urinary recovery of fluoride were determined after a single oral dose either of rapidly soluble (conventional), sustained release or enterocoated tablets. The in vivo study showed that administration of sustained release tablets eliminated high serum peaks and prolonged the duration of an elevated serum level as compared to conventional tablets. The biovailability of the fluoride was lower after intake of sustained release and enterocoated tablets, and there was an increase in the interindividual variance of biovailability.
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    URL: http://dx.doi.org/10.1007/BF00561954
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  • 20
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    Effect of food on the absorption of hydralazine in man (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 53-58 
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    ISSN: 1432-1041
    Keywords: hydralazine ; food ; absorption ; plasma level ; salivary level ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Single oral doses of hydralazine (Apresoline) 50 mg were administered on two occasions to eight healthy volunteers when fed and fasting. Blood and saliva samples were taken at intervals after dosing and analysed for drug. Heart rate and blood pressure were measured before and at intervals after dosing, at rest, after tilt and exercise. Plasma hydralazine levels showed wide inter-individual variation. The areas under the plasma concentration-time curve (0–8 h), the height of the peak plasma levels and the time to peak were not significantly different between the fed and fasting state. Salivary hydralazine levels were readily measurable but showed little correlation with plasma levels. The heart rate and pulse pressure were increased after drug both at rest, supine and erect, and after exercise for between 6 and 8 h.
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    URL: http://dx.doi.org/10.1007/BF00554667
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  • 21
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    Ketoprofen pharmacokinetics and bioavailability based on an improved sensitive and specific assay (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 127-133 
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    ISSN: 1432-1041
    Keywords: ketoprofen ; pharmacokinetics ; multipledose ; bioavailability ; assay ; modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A commercial capsule containing 50 mg of ketoprofen (Orudis), a simple capsule containing 50 mg of ketoprofen alone and 50 mg of ketoprofen in an aqueous solution were given as separate doses in a randomized sequence to 12 normal adult males. The areas under the resulting plasma concentration-time curves (AUC) were remarkably consistent for each volunteer. The bioavailability from the commerical capsule relative to that from the solution was 99.7%±10.5% and that from the simple capsule was 102%±10%. After 6 of the volunteers had taken the commercial capsule 6 hourly for thirteen doses, their AUC extrapolated to infinity was significantly higher (by 22%) than that after the single dose indicating, contrary to previous reports, accumulation upon multiple dosing. The interdose AUC after the thirteenth dose was, however, statistically indistinguishable from the AUC-to-infinity after the single dose as might be expected from linear kinetics. The ketoprofen solution generated peak plasma concentrations in only one-third the time (21±7 min) required for the capsules (commercial, 72±45; simple, 61±39 min). Despite plasma concentrations being tracked over a 200-fold range, log linearity was not established within 12 h in any of the 42 profiles obtained. A two-compartment open model was fitted to the solution data giving excellent prediction of the time-to-peak and clearance (Cl/F=5.2±1.1 l/h) as determined by eye and by log-trapezoidal rule, respectively.
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    URL: http://dx.doi.org/10.1007/BF00607149
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    Pharmacokinetics of zimelidine in humans — Plasma levels and urinary excretion of zimelidine and norzimelidine after intravenous and oral administration of zimelidine (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 135-139 
    Details
    ISSN: 1432-1041
    Keywords: zimelidine ; norzimelidine ; antidepressant ; pharmacokinetics ; bioavailability ; urinary excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five healthy adults were administered zimelidine orally (150 mg) and by intravenous infusion (20 mg) in a crossover design. Blood and urine samples were collected for a period of 28 hours after dosing and the concentrations of zimelidine and norzimelidine determined. There was no significant difference in terminal phase half-life of zimelidine after oral (4.7 h±1.3 SD) or intravenous dosing (5.1 h±0.7 SD). An average of 50% of the ingested oral dose reached the systemic circulation. Excretion of unchanged zimelidine in urine was on average 1.26% of the intravenous dose. In appears that zimelidine is completely absorbed from the gastrointestinal tract and “first-pass metabolism” in the liver reduces the bioavailability to 50%. The mean plasma half-life for norzimelidine was 22.8 h. The area under the plasma concentration time curve for norzimelidine after oral administration was 92% of that after intravenous administration. The plasma concentration of both zimelidine and norzimelidine are predicted to approach steady-state within 3–5 days.
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    URL: http://dx.doi.org/10.1007/BF00607150
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    Impaired cimetidine absorption due to antacids and metoclopramide (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 225-228 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; antacids ; metoclopramide ; absorption ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 8 healthy subjects the absorption of cimetidine was investigated when given alone, together with 60 ml aluminium/magnesium hyroxyde containing antacid (neutralising capacity 26 mmol HCl/10 ml), and together with liquid metoclopramide 14 mg. The antacid significantly (P〈0.01) reduced the bioavailability (area under the plasma level-time curve) of cimetidine, on average by one third. Metoclopramide also reduced the bioavailability by an average of 22%. The reductions were associated with significantly reduced excretion of cimetidine in urine. There was no change in the half-life or renal clearance of cimetidine, supporting the hypothesis of reduced gastrointestinal absorption. The results indicate that cimetidine and antacids should not be given together, and that the dose of cimetidine may have to be increased if it is administered concomitantly with metoclopramide.
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  • 24
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    Baldcypress allelochemics and the inhibition of silkworm enteric microorganisms Some Ecological Considerations (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 103-114 
    Details
    ISSN: 1573-1561
    Keywords: Baldcypress ; Taxodium distichum ; 2-furaldehyde ; 2-furoic acid ; Bombyx mori ; Lepidoptera ; Bombycidae ; enteric microbial inhibition ; Bacillus ; Micrococcus ; Arthrobacter ; Mucor ; Curvularia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Exposure ofBombyx mori larvae to 2-furaldehyde, a major volatile component of baldcypress heartwood,Taxodium distichum, resulted in in vivo inhibition of enteric microorganisms at concentrations (1–47 ppm) that were released naturally from heartwood. The 7 bacterial and 2 fungal enteric isolates were also inhibited in vitro at the same concentrations. It is suggested that inhibition of leaf surface micro-organisms or in vivo inhibition of silkworm enteric microflora, as a result of indirect or direct action of 2-furaldehyde, exacerbates the growth-inhibitory effects of this compound on larvae by reducing the microbial nutritional contribution. The ecological significance of insect enteric microbial inhibition by plant allelochemics is discussed.
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    URL: http://dx.doi.org/10.1007/BF00988638
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    Attractant lures for males of the pea moth,Cydia nigricana (F.) Containing (E)-10-dodecen-1-yl acetate and (E,E)-8,10-dodecadien-1-yl acetate (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 563-573 
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    ISSN: 1573-1561
    Keywords: Pea moth ; Cydia nigricana (F.) ; Lepidoptera ; Olethreutidae ; sex attractant ; (E)-10-dodecen-1-yl acetate ; (E,E)-8 ; 10-dodecadien-1-yl acetate ; lure ; formulation ; antioxidant ; monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Lures containing different amounts of (E)-10-dodecen-1-yl acetate and (E,E)-8, 10-dodecadien-1-yl acetate were formulated in natural rubber stoppers or polyethylene vials and tested in traps in the field to establish relative attractiveness to males of the pea moth,Cydia nigricana (F.), dose-response relationships, and the effects of weathering. Initially, both formulations of (E,E)-8,10-dodecadien-1-yl acetate were much more attractive than those of (E)-10-dodecen-1-yl acetate, but their activity diminished considerably after only 5 days in the field because an inhibitor was formed, and polyethylene formulations were not attractive after one week. However, lures containing (E)-10-dodecen-1-yl acetate, with or without antioxidants, in both rubber and polyethylene were still attractive after three months' exposure in the field and are therefore suitable for practical monitoring of pea moth populations.
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    URL: http://dx.doi.org/10.1007/BF00987704
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  • 26
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    Air permeation tests with (Z,Z)-3,13-octadecadien-1-ol acetate for reduction in trap catch of peachtree and lesser peachtree borer moths (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 575-582 
    Details
    ISSN: 1573-1561
    Keywords: Peachtree borer ; lesser peachtree borer ; Synanthedon exitiosa ; S. pictipes ; Lepidoptera ; Sessiidae ; Z,Z-3 ; 13-octadecadien-1-ol acetate sex pheromone ; traps ; air permeation ; trap catch reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Air permeation trials were conducted to determine whether trap catches of the peachtree borer (PTB)Synanthedon exitiosa (Say) and lesser peachtree borer (LPTB)S. pictipes (Grote and Robinson) could be reduced through application of the synthetic pheromone of the PTB, (Z,Z)-3,13-octadecadien-1-ol acetate (Z,Z-ODDA), at 92% isomeric purity. The pheromone was released into the air of peach orchard test plots with hanging laminated plastic dispensers or hollow fiber dispensers in the trees and by aerial dispersal of microcapsules containing a solution of the lure. Results showed that all formulations ofZ, Z-ODDA reduced trap catches of both PTB and LPTB in treated plots relative to catches in traps in untreated plots. In one air permeation experiment, three types of laminated dispensers and one type of hollow fiber dispenser each reduced trap catch of PTB by 93–100% and of LPTB by 75–95%. In a separate test, two formulations of microencapsulatedZ,Z-ODDA did not reduce trap catch of male PTB as effectively as the laminated dispenser; results for LPTB were similar for both the dispensers and microcapsules. Catches of male PTB moths in traps baited with laminated and or fiber pheromone dispensers containing ODDA (94∶6%Z,Z∶E,Z) were not significantly different. LPTB male moths were also captured in these traps, the catches being dependent upon the initial pheromone loading and the type of dispensers.
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    URL: http://dx.doi.org/10.1007/BF00987705
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  • 27
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    Insect sex pheromones: Evaporation rates of alcohols and acetates from natural rubber septa (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 627-633 
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    ISSN: 1573-1561
    Keywords: Insect sex pheromones ; insect sex attractants ; Lepidoptera ; pheromones ; pheromone formulations ; insect population monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The half-lives (t 1/2) of alcohol sex pheromones, 1-alkanols, acetate sex pheromones, and an epoxide (disparlure) were determined on natural rubber septa. Thet 1/2 values for the homologous alcohols from decanol to heptadecanol increased regularly from 2.2 to 1117 days, but thet 1/2 of octadecanol was 609 days. Thet 1/2 values of (Z)7-, (E)7-, and (Z)9-tetradecen-1-ol acetates were 154, 168, and 199 days, respectively, whereas those of five other tested 14-carbon acetates ranged from 310 to 350 days. The dependence oft 1/2 values on chain length and double-bond position is consistent with the hypothesis that molecular size is an important variable affectingt 1/2 values. Also, in accordance with the hypothesis, when aZ-alkenyl compound has a much shortert 1/2 than the corresponding saturated compound, thet 1/2 values of theZ compound and itsE isomer may be quite different. Thus, (E)-9-tetradecen-l-ol acetate had at 1/2 of 331 days. Thet 1/2 of disparlure was 180 days. The effect of thecis-7,8 epoxide group is apparently similar to that of the olefin group in lowering thet 1/2 below the value that would be expected solely on the basis of chain length.
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    Relative efficiency of sticky and cylindrical electrical grid traps in capturingSpodoptera exigua (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 733-740 
    Details
    ISSN: 1573-1561
    Keywords: Beet armyworm ; Spodoptera exigua ; Lepidoptera ; Noctuidae ; pheromone trap ; trap efficiency ; Pherocon 1C trap ; population monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The relative efficiency of sticky traps and cylindrical electrical grid traps for capturing male beet armyworm moths,Spodoptera exigua (Hubner), was studied using night vision equipment. The sticky and grid traps captured 34 and 40%, respectively, of the insects which oriented to them. The grid trap's capacity was limited only by the size of the receptacle (3.8-liter bucket) at the base of the funnel. The maximum capacity of the sticky trap was ca. 110 insects, and the efficiency of this trap declined rapidly when captures exceeded 50% capacity. This decline was caused by the physical blockage of the sticky surface by the captured insects. There was no evidence to indicate that captured males had any repelling effect on other males subsequently attracted to the sticky trap.
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    Kairomones and their use for management of entomophagous insects (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 909-917 
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    ISSN: 1573-1561
    Keywords: Trichogramma pretiosum ; Hymenoptera ; Trichogrammatidae ; biological control ; kairomone ; Heliothis zea ; Lepidoptera ; Noctuidae ; host density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Trichogramma pretiosum Riley females exhibit success-motivated searching after oviposition. The stimulatory effect of contact with host eggs makes host-egg density an important factor in determining the appropriate strategy for behavioral manipulation, using kairomones, that simulate host seeking, in biological control programs. Host eggs can be used, in conjunction with kairomones or by themselves, to improve the performance of these important beneficial insects.
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    Continuous transepidermal drug collection: Basis for use in assessing drug intake and pharmacokinetics (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 41-58 
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    ISSN: 1573-8744
    Keywords: transepidermal ; pharmacokinetics ; bioavailability ; drug surveillance ; compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Continuous transepidermal drug collection (CTDC) has been proposed for use in assessing ethanol intake and in monitoring compliance with therapeutic regimens. Exploration of a theoretical basis for use of CTDC in these circumstances and for its use in assessing other aspects of drug disposition kinetics was undertaken. Effects of single and multicompartmental drug disposition models, single dose and multiple dose regimens, with regular and irregular doses and dosing intervals, and zero-order, first-order, and Michaelis-Menten excretion patterns were explored. First-order transepidermal drug transfer was assumed with and without back transfer from the collection device. These analyses suggest that the utility of CTDC is severely restricted when back transfer from the collection device is substantial. With back transfer minimized, CTDC may be a useful tool for assessing amount of drug exposure, compliance with therapeutic regimens, and relative bioavailability, but offers little advantage over discrete sampling of other body fluids in the study of other aspects of drug disposition kinetics.
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    Dose dependent pharmacokinetics of prednisone and prednisolone in man (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 389-417 
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    ISSN: 1573-8744
    Keywords: Prednisone ; prednisolone ; dose-dependent ; pharmacokinetics ; biotransformation ; protein binding ; bioavailability ; transcortin binding ; interconversion ; renal clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Six healthy male volunteers were given 5, 20, and 50 mg of oral prednisone and 5, 20, and 40 mg doses of intravenous prednisolone. Plasma and urine concentrations of prednisone and prednisolone were determined by HPLC, and the binding of prednisolone to plasma proteins was measured by radioisotopic and equilibrium dialysis techniques. The pharmacokinetics of both oral prednisone and intravenous prednisolone were dose-dependent. The mean oral dose plasma clearances of prednisone ranged from 572 ml/min/ 1.73 m 2 for the 5mg dose to 2271 ml/min/1.73 m 2 for the 50 mg dose. Changes in prednisone half-life were insignificant, but increases in the half-life of its metabolite were dose-dependent. The systemic plasma clearance of i.v. prednisolone was dose-dependent and increased from 111 to 194 ml/min/1.73 m 2 over the 5 to 40 mg i.v. dosage range. The steady-state volume of distribution also increased, but little change in mean transit time and half-life was found. The binding of prednisolone to plasma proteins was markedly concentration-dependent, and a two compartment, nonlinear equation was used to characterize the effective binding of prednisolone to transcortin and albumin. The apparent pharmacokinetic parameters of protein-free and transcortin-free prednisolone were relatively constant with dose. The interconversion of prednisone and prednisolone varied with time and dose, although prednisolone concentrations dominated by 4-to 10-fold over prednisone. In urine, 2–5% of either administered drug was excreted as prednisone and 11–24% as prednisolone. The apparent renal clearances of both steroids were also nonlinear and unrelated to protein binding. These studies indicate that the pharmacokinetics of prednisone and prednisolone are dose-dependent and that protein binding does not fully explain their apparent nonlinear distribution and disposition.
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    Pharmacokinetic study of sisomicin in humans (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 535-551 
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    ISSN: 1573-8744
    Keywords: sisomicin ; pharmacokinetics ; bioavailability ; two-compartment open model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Detailed analyses of the pharmacokinetics of sisomicin administered at doses of 25, 50, and 100 mg intravenously and intramuscularly to healthy volunteers established that the drug is handled by a two-compartment open model system with a disposition (elimination) half-life of 2.6 hr. The kinetic estimates over this dose range are linear and independent of dose and were verified by a 60-min infusion experiment in which dose and the maximum serum concentration achieved (5 μg/ml) were predicted correctly. Sisomicin was rapidly distributed to the tissue compartment, and equilibrium between the central and the tissue compartment was established by 30 min after dosing. Renal clearance (55 ml/min) of sisomicin was about 30% less than total body clearance (78 ml/min). Total urinary excretion of sisomicin during a 24-hr period following drug administration was about 70% of the dose. The disposition kinetics of sisomicin following intramuscular administration are similar to those obtained following rapid intravenous administration. Intramuscular bioavailability of sisomicin for the doses of 25, 50, and 100 mg was greater than 95%. Based on these results, various initial loading infusion doses and maintenance infusion rates were calculated to provide specific desired peak and steady-state serum sisomicin concentrations rapidly. The purpose was not to expose patients to potentially toxic high peak concentrations of drug while maintaining these concentrations during the current therapeutic dosing intervals of 8 to 12 hr.
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    URL: http://dx.doi.org/10.1007/BF01061025
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    Clinical bioavailability evaluation of a controlled release formulation of diazepam (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 679-691 
    Details
    ISSN: 1573-8744
    Keywords: diazepam ; controlled release ; bioavailability ; single dose ; steady-state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A controlled release formulation of diazepam was compared to equal daily doses of the trade tablet under single day and steadystate conditions. Virtually no differences were found in the mean steadystate concentrations of diazepam or its metabolite, N-desmethyldiazepam, when the subjects received the 5 mg trade tablet three times daily or the 15 mg controlled release formulation once daily. Similarly, there was no difference in mean diazepam or N-desmethyldiazepam plasma concentrations when single doses of the controlled release formulation were given to fed or fasted volunteers. These data indicate that the controlled release formulation produces plasma concentrations of diazepam and N-desmethyldiazepam comparable to those achieved with the same daily dose of the trade product given three times daily, suggesting that these regimens can be used interchangeably.
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    Oral absorption and presystemic first-pass effect of chlorpheniramine in rabbits (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 725-738 
    Details
    ISSN: 1573-8744
    Keywords: pharmacokinetics ; chlorpheniramine ; first-pass effect ; bioavailability ; gut metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The oral absolute bioavailabilities of chloropheniramine (CPM) in four rabbits (New Zealand White, male, mean wt. 3.71 kg), averaged 0.06±0.03, 0.11±0.08, and 0.09±0.01 following a 3, 10.5, and 21 mg/kg dose, respectively. The individual bioavailability data and the AUCof one of the demethylated metabolites, desdimethyl CPM (DDCPM) obtained following different doses suggested the existence of saturable presystemic elimination. Two rabbits received an additional 10.5 mg/kg dose of CPM through portal vein infusion. Based on the oral, intraportal vein and i.v. studies, the mean extraction ratios of gut and the liver calculated for these two rabbits averaged 0.58 and 0.76, respectively. The latter value agreed well with the estimated hepatic extraction ratio from the in vitro liver homogenate study (0.89) or from the i.v. studies (0.83). The extensive prehepatic first-pass effect observed in the present study was consistent with similar findings in humans and dogs.
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    Effect of smoking on prednisone, prednisolone, and dexamethasone pharmacokinetics (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 1-14 
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    ISSN: 1573-8744
    Keywords: prednisone ; prednisolone ; dexamethasone ; pharmacokinetics ; tobacco ; smoking ; bioavailability ; corticosteroids ; enzyme induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of oral prednisone and oral dexamethasone were examined in 18 healthy male adults. Eight subjects also received intravenous prednisolone and intravenous dexamethasone. Half of each group were cigarette smokers as confirmed by plasma thiocyanate concentrations. Plasma and urine concentrations of prednisone and prednisolone were assayed by high performance liquid chromatography, while plasma dexamethasone was measured by radioimmunoassay. There were no statistically significant differences between smokers and nonsmokers in the systemic availability of prednisolone (75 versus 84%), oral dose clearance of prednisone (29 versus 27 ml/min/kg), systemic prednisolone clearance (2.8 versus 2.9 ml/min/kg), or in the interconversion rates, volumes of distribution, or urinary recoveries of prednisone and prednisolone. Similarly, the pharmacokinetics of dexamethasone were unaffected by smoking. A limited correlation (r=0.55) was found between the high oral dose clearances of prednisone and the lower values of dexamethasone (6.73 and 5.71 ml/min/kg in smokers and nonsmokers). A two- to threefold variability occurred in oral dose clearances of each steroid with partial intrasubject covariance. Unlike the anticonvulsants, which markedly induce corticosteroid metabolism, smoking has no effect on their pharmacokinetics and should not complicate therapy with these drugs.
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    2-Furaldehyde from baldcypress (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 89-101 
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    ISSN: 1573-1561
    Keywords: Baldcypress ; Taxodium distichum ; 2-furaldehyde ; Bombyx mori ; Lepidoptera ; Bombycidae ; growth inhibition ; toxicity ; Georgia silkworm industry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract 2-Furaldehyde was growth inhibitory and toxic to larvae ofBombyx mori at concentrations as low as 1 ppm. Baldcypress,Taxodium distichum, heartwood released this volatile at concentrations in excess of these levels. The adverse effect of this chemical on silkworms may partially account for the demise of the Georgia silkworm industry (circa 1765), after the construction of a baldcypress rearing facility.
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    Synthesis of sex pheromone components of the forest tent caterpillar,Malacosoma disstria (Hübner) and of the western tent caterpillar,Malacosoma californicum (Packard) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 159-164 
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    ISSN: 1573-1561
    Keywords: Synthesis ; isomers ; 5,7-dodecadienal ; sex pheromone ; Malacosoma disstria ; Malacosoma californicum ; Lepidoptera ; Lasiocampidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract All four geometrical isomers of 5,7-dodecadien-1-ol have been stereoselectively synthesized by using Wittig condensation reactions. (5 Z,7E)-5,7-Dodecadien-1-ol and its corresponding aldehyde are components of the sex pheromone of the forest tent caterpillar. (5 E,7 Z)-5,7-Dodecadienal is a component of the pheromone of the western tent caterpillar. These compounds have been successfully tested in the field.
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    Feeding preferences of spruce budworm (Choristoneura fumiferana Clem.) larvae to some host-plant chemicals (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 391-402 
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    ISSN: 1573-1561
    Keywords: Choristoneura fumiferana ; Lepidoptera ; Tortricidae ; Abies balsamea ; feeding stimulants ; feeding deterrents ; feeding preference ; sugars ; glycosides ; amino acids ; organic acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Single-choice and three-choice tests were used to determine the relative importance of host-plant chemical extracts in eliciting feeding by spruce bud worm larvae. Water-soluble components of the host trees are the most important and, of these, the sugar and glycoside fractions are the most stimulating. The amino acid and organic base fractions have no apparent effect. The organic acid fractions deter feeding slightly.
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    A four-component pheromone blend for optimum attraction of redbacked cutworm males,Euxoa ochrogaster (Guenée) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 615-625 
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    ISSN: 1573-1561
    Keywords: Redbacked cutworm ; Euxoa ochrogaster ; Lepidoptera ; Noctuidae ; sex pheromone blend ; sex attractant ; parapheromone ; Z-5-decenyl acetate ; Z-5-undecenyl acetate ; Z-5-dodecenyl acetate ; Z-7-dodecenyl acetate ; Z-9-dodecenyl acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Four acetates,Z-5-decenyl acetate,Z-5-,Z-7-, andZ-9-dodecenyl acetates, in microgram ratios of 1∶200∶2∶1 or 1∶200∶6∶2 were excellent, specific sex pheromone blends for capturing male redbacked cutworm moths in cone traps. Blends in ratios of 1∶200∶2∶1 and 2∶200∶2∶1 at 1000 μg/ rubber septum dispenser remained highly effective for 6 weeks under field conditions. The essential minor components,Z-5-decenyl,Z-7-, andZ-9-dodecenyl acetates, became inhibitory at concentrations of about 10% in the blends, and this may be an important general phenomenon in lepidopteran pheromones. Blends involving a parapheromone,Z-5-undecenyl acetate, withZ-5-,Z-7-, andZ-9-dodecenyl acetate, in microgram ratios of 8∶200∶2∶1 or 20∶200∶6∶2 were also excellent specific attractants for this species. TheZ-8-dodecenyl acetate had no obvious effect on the attraction of the redbacked cutworm males.
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    Kairomones and their use for management of entomophagous insects: X. Laboratory studies on manipulation of host-finding behavior ofTrichogramma pretiosum riley1 with a kairomone extracted fromHeliothis zea (boddie) moth scales (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 635-648 
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    ISSN: 1573-1561
    Keywords: Kairomone ; parasitoids ; biological control ; Trichogramma pretiosum ; Hymenoptera ; Trichogramma tidae ; Heliothis zea ; Lepidoptera ; Noeturidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The behavioral response ofTrichogramma pretiosum Riley females to the kairomone found inHeliothis zea (Boddie) moth scales is examined.
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    Sex pheromone of the saltmarsh caterpillar moth,Estigmene acrea (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 655-668 
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    ISSN: 1573-1561
    Keywords: Saltmarsh caterpillar moth ; Estigmene acrea ; (Z,Z)-9,12-octadecadienal ; (Z,Z,Z)-9,12,15-octadecatrienal ; (Z,Z)-3,6-cis-9,10-epoxy-heneicosadiene ; fall webworm moth ; Hyphantria cunea ; insect sex pheromone ; cis-9,10-epoxyheneicosane ; trans-9,10-epoxyheneicosane ; linolealde-hyde ; linolenaldehyde ; Lepidoptera ; Arctiidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Three compounds have been identified as components of the sex pheromone emitted by females of the saltmarsh caterpillar moth,Estigmene acrea (Drury). These are (Z,Z)-9,12-octadecadienal (I), (Z,Z,Z)-9,12,15-octadecatrienal (II), and (Z,Z)-3,6-cis-9,10-epoxyheneicosadiene (III). In female tip extract they were found in a ratio of 1∶6∶25, respectively, and in trapped female effluvia the ratio was 1∶6∶27, respectively. Combinations of III with either I or II elicited sustained upwind flight in a wind tunnel, but none of these compounds by themselves did so. There is evidence that the antennal acceptor site for III is chiral.
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    Comparative distribution and persistence of disparlure in woodland air after aerial application of three controlled-release formulations (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 867-880 
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    ISSN: 1573-1561
    Keywords: Disparlure ; gypsy moth ; Lymantria dispar ; Lepidoptera ; Lymantriidae ; controlled release ; laminated dispensers ; hollow fibers ; microcapsules ; atmospheric permeation ; mating disruption ; air concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Disparlure, the gypsy moth sex pheromone, was aerially applied to three plots, using a different controlled-release formulation-gelatin microcapsules, flakes of plastic laminates, or hollow fibers-in each plot. Disparlure concentrations in air were measured intermittently over a 34-day period after application. Measurements were made at four heights above ground: 0.3,2,5, and 10m. Wind speed and air temperature were measured concurrently. Disparlure was emitted from the microcapsules and fibers at very high levels for the first day or two; thereafter, all three formulations produced gradually decreasing aerial concentrations. After 32–34 days, concentrations in all plots ranged from 1.5% to 15.5% of those on the first day, although most of the pheromone remained in the formulations. Results suggest that the effective life of all three formulations for mating disruption by atmospheric permeation would be near 30 days under the test conditions, with fibers likely to have the shortest life. Concentrations varied diurnally throughout the experiment, with highest levels generally between 1400 and 2200 hr each day. Concentrations were highest at the 10-m height with microcapsules and at the 0.3- and 10-m heights with flakes, but were similar at all heights with fibers. Biological implications of the results are presented.
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    Analysis of field-weathered lures containing (E)-10-dodecen-1-yl acetate, a sex attractant for the pea moth,Cydia nigricana (F.) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 1049-1056 
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    ISSN: 1573-1561
    Keywords: Pea moth ; Cydia nigricana (F.) ; Lepidoptera ; Olethreutidae ; sex attractant ; (E)-10-dodecen-1-yl acetate ; lure ; formulation ; monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Natural rubber stoppers treated with 1, 3, or 10 mg of (E)-10-dodecen-1-yl acetate, an attractant for male pea moth,Cydia nigricana (F.), were exposed in the field during the summer of 1978 and samples analyzed at intervals. The results for all three doses fitted well to first-order loss curves with half-lives of 63.5, 64.7, and 67.3 days, respectively. Thus, lures with an initial dose of 3 mg of the attractant retained approximately 1 mg after 3 months of field exposure; they should therefore maintain a constant level of attractiveness throughout this period because previous field studies showed that moths were equally responsive to fresh lures containing between 1 and 10 mg of the attractant. There was no loss of attractant during the preparation of lures or after 4 months at −15 ° C and only 13% was lost during 3 months of storage at room temperature.
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    Sex pheromone of the tomato looper,Plusia chalcites (ESP) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 1081-1088 
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    ISSN: 1573-1561
    Keywords: Plusia chalcites ; Lepidoptera ; Noctuidae ; tomato looper ; sex pheromone identification ; glass WCOT capillary chromatography ; gas chromatography-mass spectrometry ; Z-7-dodencenyl acetate ; Z-9-tetra-decenyl acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Z-7-Dodecenyl acetate (A) andZ-9-tetradecenyl acetate (B), in a 5∶1 ratio, have been identified as sex pheromone components of femalePlusia chalcites. In addition, small amounts of dodecyl acetate, tetradecyl acetate, hexadecyl acetate, andZ-9-dodecenyl acetate have been found in the abdominal tip extracts. This is the first known Plusiinae species which utilizes a two-component primary sex pheromone system. The most effective lure found in field experiments was a mixture of 1 mg A and 0.2 mg B absorbed on rubber septa.
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    Larval osmeterial secretions of the swallowtails (Papilio) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 1089-1113 
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    ISSN: 1573-1561
    Keywords: Osmeterial secretion ; Papilio larvae ; Lepidoptera ; monoterpene ; sesquiterpene ; aliphatic acid ; ester
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The larval osmeterial secretions of sixPapilio species examined displayed a remarkable qualitative change at the fourth larval ecdysis. The secretions of 4th (penultimate) instar larvae ofP. machaon, P. memnon, P. helenus, P. bianor, andP. maackii principally comprised mono- and/or sesquiterpenoids. The compounds identified from these species included α-pinene, sabinene, β-myrcene, limonene, β-phellandrene, (Z)-β-ocimene, (E)-β-ocimene, β-elemene, β-caryophyllene, (E)-β-farnesene, β-selinene, (E,E)-α-farnesene, germacrene-A, germacrene-B, caryophyllene oxide, methyl 3-hydroxy-n-butyrate, and acetic acid. In contrast, the secretion of 4th larval instar ofP. xuthus, although containing similar terpenic compounds, was accompanied by large amounts of aliphatic acids and their esters: isobutyric acid, 2-methylbutyric acid, methyl isobutyrate and methyl 2-methylbutyrate. On the other hand, the osmeterial secretions of 5th (last) instar larvae varied little in quality among the six species, and the identified compounds consisted of isobutyric acid, 2-methylbutyric acid, methyl isobutyrate, ethyl isobutyrate, methyl 2-methylbutyrate, ethyl 2-methylbutyrate, and isovaleric acid, the last of which was specific toP. bianor andP. maackii. The chemical alteration of osmeterial exudate synchronized at the final larval ecdysis with the larval morphological change (particularly in body coloration) that appears to be of defensive significance against predators.
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    On the persistence of disparlure in the human body (1981)
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    Journal of chemical ecology 7 (1981), S. 313-317 
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    ISSN: 1573-1561
    Keywords: Disparlure ; Lymantria dispar ; Lepidoptera ; Lymantriidae ; pheromone persistence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Response of male gypsy moths from a sparse infestation in Italy to an observer apparently contaminated with disparlure at least two years previously is reported. Other examples of pheromone contamination of people or things are also recorded.
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    Comparing the effectiveness of sexual communication disruption in the oriental fruit moth (Grapholitha molesta) using different combinations and dosages of its pheromone blend (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 501-508 
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    ISSN: 1573-1561
    Keywords: Disruption of communication ; Oriental fruit moth ; Grapholitha molesta ; Lepidoptera ; Tortricidae ; sex pheromone ; sex attractant ; (Z)-8-dodecenyl acetate ; (E)-8-dodecenyl acetate ; (Z)-8-dodecen-1-ol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The relative efficacy of disruptant blends comprised of different combinations of the Oriental fruit moth's pheromone components was determined in field tests. Disruption was evaluated by comparing male moth catch at synthetic and female-baited traps in disruptant and non-treatment areas. Three atmospheric dosages of a 8-dodecenyl acetate (93.5%Z∶6.5%E) blend, representing two successive 10-fold decreases in concentration (2.5 × 10−2 g/hectare/day to 2.5 × 10−4 g/hectare/day) were tested alone and in combination with an additional percentage of (Z)-8-dodecen-1-ol. Male moth orientation to traps was eliminated in plots exposed to the two highest binary acetate dosages. However, significantly more males were captured in synthetic-baited traps in the lowest acetate-alone treatment, indicating a diminution of disruption efficiency. In contrast, inclusion of (Z)-8-dodecen-1-ol in the disruptant blend effected essentially complete disruption of orientation at all concentrations tested. Mating success ofG. molesta pairs confined in small cages apparently was not affected by the presence of relatively high concentrations of the binary acetate and the acetate-alcohol blends. This suggests that habituation and/or adaptation of male response, at least for comparatively “close-range” behaviors, did not occur.
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    Seven-week persistence of an oviposition-deterrent pheromone (1981)
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    Journal of chemical ecology 7 (1981), S. 583-588 
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    ISSN: 1573-1561
    Keywords: Oviposition ; deterrent pheromone ; Pieris brassicae ; Lepidoptera ; Pieridae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Cabbage leaves sprayed with a water solution of the oviposition-deterrent pheromone ofPieris brassicae remain deterrent to ovipositing females for at least 14 days. Under laboratory conditions, the pheromone, when dried on a glass surface, retains activity for a period of at least 7 weeks. After 7 days under vacuum conditions, some pheromone is still present, indicating a low volatility and / or high stability of (an active fraction of) the pheromone. After 125 eggs are slowly rinsed with 300 ml water, they still release detectable quantities of the pheromone.
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    Effect of day length and light intensity on 2-tridecanone levels and resistance inLycopersicon hirsutum f.glabratum toManduca sexta (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 707-716 
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    ISSN: 1573-1561
    Keywords: Manduca sexta (L.) ; Lepidoptera ; Sphingidae ; Lycopersicon hirsutum f.glabratum ; day length ; light intensity ; 2-tridecanone ; glandular trichome ; resistance ; allelochemic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract First instarManduca sexta (L.) larvae confined on foliage fromLycopersicon hirsutum f.glabratum (accession PI 134417) plants grown under a long-day regime exhibited greater mortality than larvae on foliage from plants grown under a short-day regime. 2-Tridecanone, a toxin important in the insect resistance of PI 134417, was significantly more abundant in the foliage of plants grown under the long-than the short-day regimes. Light intensity influenced neither 2-tridecanone levels nor the expression of resistance. The density of glandular trichomes, which secrete 2-tridecanone, was influenced by an interaction between day length and light intensity.
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    Growth inhibitors in tomato (Lycopersicon) to tomato fruitworm (Heliothis zea) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 753-758 
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    ISSN: 1573-1561
    Keywords: Lycopersicon esculentum ; Lycopersicon hirsutum f. glabratum Heliothis zea ; Lepidoptera ; Noctuidae ; α-tomatine ; rutin ; chlorogenic acid ; caffeyl aldaric acid ; allelochemics ; tomato ; tomato fruitworm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Several compounds that retard the larval growth of the tomato fruitworm,Heliothis zea (Boddie) have been isolated and identified from tomato leaves,Lycopersicon esculentum Mill. The major allelochemics are α-tomatine (I), chlorogenic acid (II), rutin (III), and a new caffeyl derivative of an aldaric acid (IV). The isolation, analyses, and toxicity of these compounds toH. zea are presented.
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    Biological amplification for increasing electroantennogram discrimination between two female sex pheromones ofSpodoptera littoralis (Lepidoptera: Noctuidae) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 791-798 
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    ISSN: 1573-1561
    Keywords: Spodoptera littoralis ; Lepidoptera ; Noctuidae ; electroantennogram ; biological amplification ; pheromones ; Boarmia selenaria ; Geometridae ; Matsucoccus josephi ; Homoptera ; Coccoidea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract MaleSpodoptera littoralis stimulated by a mixture ofS. littoralis female sex pheromone with a positional isomer and by the pheromone alone, gave greatly amplified electroantennograms (EAGs) when the antennae were connected in series. The technique is described and examples are given of its use in screening extracts for EAG activity. Dose-response curves obtained with this technique are presented and discussed. Through biological amplification, EAG discrimination between the pheromones was increased.
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    Alleviation of α-tomatine-induced toxicity to the parasitoid,Hyposoter exiguae, by phytosterols in the diet of the host,Heliothis zea (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 927-946 
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    ISSN: 1573-1561
    Keywords: Host-plant resistance ; α-tomatine ; sterols ; sterol esters ; Lycopersicon esculentum ; Heliothis zea ; Lepidoptera ; Noctuidae ; parasitoids ; Hyposoter exiguae ; Hymenoptera ; Ichneumonidae ; secondary compounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The solitary, endoparasitic ichneumonid,Hyposoter exiguae (Viereck) is a parasitoid of the tomato fruitworm,Heliothis zea (Boddie). However, the parasitoid is deleteriously affected by the tomato glycoalkaloid, α-tomatine, ingested from hosts (H. zea) fed on artificial diets or semipurified extracts of tomato plants that contained α-tomatine. α-Tomatine causes prolonged larval development; disruption or prevention of pupal eclosion; deformation of antennal, abdominal, and genital structures; and reduction in adult weight and longevity of the parasitoid. These toxic effects are exacerbated when the dietary dose of α-tomatine is increased from 12 μmol to 20 μmol/g dry wt of diet. However, the toxicity of α-tomatine is attenuated in parasitoids reared from hosts fed on artificial diets that contain equimolar or supramolar amounts of 3β-OH-sterols admixed with α-tomatine. Further, the toxicity of extracts from the foliage of different cultivars of tomatoes toH. exiguae is contingent upon the composite levels of α-tomatine and total phytosterol (free and esterified). Cultivars with a low total sterol-tomatine ratio are more toxic toH. exiguae. The possible mode of action of α-tomatine toxicity toH. exiguae by disruption of sterol metabolism is discussed.
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    Kairomones and their use for management of entomophagous insects (1981)
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    Journal of chemical ecology 7 (1981), S. 1057-1061 
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    ISSN: 1573-1561
    Keywords: Heliothis zea ; Lepidoptera ; Noctuidae ; Microplitis croceipes ; Hymenoptera ; Braconidae parasitoids ; kairomones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In laboratory experiments conducted to compare the kairomonal activity forMicroplitis croceipes (Cresson) of frass fromHeliothis zea (Boddie) larvae fed on different host plants,M. croceipes females responded to extracts of frass from larvae reared on cotton or soybeans but not on corn. The lack of response to frass from larvae reared on corn was shown to be a result of a lack of some appropriate chemical(s) in the corn.
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    URL: http://dx.doi.org/10.1007/BF00987627
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    Sex pheromone components isolated from china corn borer,Ostrinia furnacalis guenée (lepidoptera: Pyralidae), (E)- and (Z)-12-tetradecenyl acetates (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 841-851 
    Details
    ISSN: 1573-1561
    Keywords: Lepidoptera ; Pyralidae ; Ostrinia furnacalis ; sex pheromone ; corn borer ; (E)-12-tetradecenyl acetate ; (Z)-12-tetradecenyl acetate ; tetradecyl acetate ; gas chromatography-mass spectrometry ; selected ion monitoring technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The sex pheromone components from the corn borer spreading widely in China,Ostrinia furnacalis Guenée, have been identified as (E)-and (Z)-12-tetradecenyl acetates (E andZ12–14∶ Ac). The ratio ofE isomer toZ isomer was 53 ∶ 47. Traps containing 1 × 10−7−1 × 10−5 g of these compounds captured more males than did live females or their tip extract (3–6 female equivalents). Tetradecyl acetate (14 ∶ Ac) was also identified in the tip extract. Its quantity was about 1.8 times the sum of the other two isomers. However, including this compound in its natural ratio in pheromone traps resulted in a decrease in trap catches (P〈 0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00992382
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  • 55
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    Identification of a sex pheromone ofHeliothis subflexa (GN.) (Lepidoptera: Noctuidae) and field trapping studies using different blends of components (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 1011-1022 
    Details
    ISSN: 1573-1561
    Keywords: Sex pheromone ; Heliothis subflexa ; Lepidoptera ; Noctuidae ; reproductive behavior ; field trapping ; capillary chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Eight compounds were isolated from the sex pheromone gland ofHeliothis subflexa (Gn.) and identified as hexadecanal, (Z)-9-hexadecenal, (Z)-11-hexadecenal, (Z)-7-hexadecen-1-ol acetate, (Z)-9-hexadecen-1-ol acetate, (Z)-11-hexadecen-1-ol acetate, (Z)-9-hexadecen-1-ol, and (Z)-11-hexadecen-1-ol. Although the whole blend was found to be an effective male attractant, the deletion of alcohols from the blend increased trap captures considerably. Further, although the binary mixture of (Z)-9-hexadecenal and (Z)-11-hexadecenal caught some maleH. subflexa, significant increases in captures were noted when the three acetate components were included in the blend.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00987623
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  • 56
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    Ultrastructural study of the postembryonic development of the neural lamella of Galleria mellonella L. (Lepidoptera) (1981)
    Springer
    Cell & tissue research 217 (1981), S. 425-433 
    Details
    ISSN: 1432-0878
    Keywords: Lepidoptera ; Neural lamella ; Postembryonic development ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The neural lamella encapsulating the brain of the wax moth Galleria mellonella develops from a very thin (80–120 nm) layer in the first larval instar, resembling the basal lamina, to a thick (1–4 μm) sheath composed of two zones in the seventh (last) instar. After its breakdown at the time of larval-pupal ecdysis the neural lamella is reconstructed in the pupa, 2–3 days before pupaladult ecdysis. The cells of the perineurium seem to be responsible for the formation of the neural lamella, both in the larva and pupa, even though its ultrastructure differs at these stages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233592
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