Summary
Nine healthy volunteers received single 0.25, 0.5, 1.0, 1.5, and 2.0 mg doses of oral digoxin tablets in random sequence on five occasions separated by at least 4 weeks. Urinary excretion of immunoassayable digoxin was determined from 8 consecutive 24 h urine samples collected after each dose. Mean values of cumulative urinary excretion of digoxin at the 5 doses were: 40.9, 35.6, 36.4, 34.1, and 33.5% of the dose (F=0.64; d. f.=4.32; N. S.). Mean values of urinary excretion half-life were: 2.48, 2.03, 2.20, 2.07, and 1.87 days (F=2.87; d. f.=4.32;p=0.05). Thus, the bioavailability of orally administered digoxin tablets in healthy volunteers is dose-independent over an 8-fold range of doses.
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Supported in part by the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, Federal Republic of Germany; by Sandoz Studienstiftung, Basel, Switzerland; and by Grant MH-12279 from the United States Public Health Service
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Ochs, H.R., Bodem, G. & Greenblatt, D.J. Effect of dose on bioavailability of oral digoxin. Eur J Clin Pharmacol 19, 53–55 (1981). https://doi.org/10.1007/BF00558384
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DOI: https://doi.org/10.1007/BF00558384