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  • Cell Line  (54)
  • Rats, Inbred Strains  (51)
  • American Association for the Advancement of Science (AAAS)  (105)
  • American Meteorological Society (AMS)
  • Annual Reviews
  • 1990-1994
  • 1980-1984  (105)
  • 1983  (65)
  • 1981  (40)
Sammlung
Schlagwörter
Verlag/Herausgeber
  • American Association for the Advancement of Science (AAAS)  (105)
  • American Meteorological Society (AMS)
  • Annual Reviews
Erscheinungszeitraum
  • 1990-1994
  • 1980-1984  (105)
Jahr
  • 1
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    Renin and angiotensin: the complete system within the neuroblastoma x glioma cell (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-20
    Beschreibung: Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108-15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum withdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, M C -- Zimmerman, E A -- Slater, E E -- HL-21247/HL/NHLBI NIH HHS/ -- HL-24105/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272392" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Angiotensin I/*analysis ; Angiotensin II/*analysis ; Angiotensins/*analysis ; Animals ; Cell Line ; Cricetinae ; Glioma/*metabolism ; Hybrid Cells/*metabolism ; Mice ; Neuroblastoma/*metabolism ; Peptidyl-Dipeptidase A/metabolism ; Radioimmunoassay ; Rats ; Renin/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Increased intracranial self-stimulation in rats after long-term administration of desipramine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-06
    Beschreibung: The effects of long- and short-term administration of the tricyclic antidepressant desipramine on intracranial self-stimulation in rats were studied with electrodes in the A10 region of the dopamine-containing cell bodies of the ventromedial tegmentum. Long-term desipramine administration resulted in a significant shift to the left in the ascending portion of the rate--current intensity function, indicating that the activity of the mesolimbic dopamine system was enhanced. These findings point to a possible dopaminergic mechanism of action of antidepressants and support speculations concerning the role of dopamine-containing neurons in the pathophysiology of depression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fibiger, H C -- Phillips, A G -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):683-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7197394" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Depression/physiopathology ; Desipramine/*administration & dosage ; Dopamine/*physiology ; Humans ; Limbic System/*physiology ; Male ; Rats ; Rats, Inbred Strains ; Self Stimulation/*drug effects ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Malignant potential of murine stromal cells after transplantation of human tumors into nude mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-03
    Beschreibung: Human malignant cancer tumors grafted into nude mice produce tumors containing both human cancer cells and the host's stromal cells. After short-term propagation of these tumors in vitro, the murine mesenchymal cells appear transformed and are tumorigenic in nude mice. However, established human cancer cell lines fail to similarly after adjacent murine stromal cells when used to produce tumors in nude mice. These experiments suggest that cancer cells may recruit normal cells to become malignant, qualifying the view of the clonal (unicellular) origin of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Pavia, R A -- 1R01 CA17198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209521" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/pathology ; Animals ; Cell Line ; Cells, Cultured ; Colonic Neoplasms/pathology ; Fibrosarcoma/*etiology ; Humans ; Karyotyping ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental/*etiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Insulin as a potent, specific growth factor in a rat hepatoma cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-02-27
    Beschreibung: A line or rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G1 phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koontz, J W -- Iwahashi, M -- AM 24047/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):947-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008195" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Cycle/drug effects ; Cell Division/drug effects ; Cell Line ; *Growth Substances ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/*pathology ; Mitosis/drug effects ; Proinsulin/pharmacology ; Rats ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Dietary restriction retards the age-associated loss of rat striatal dopaminergic receptors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-30
    Beschreibung: In male Wistar rats subjected to dietary restriction by alternate days of feeding and fasting the normal age-associated loss of striatal dopamine receptors in the brain was substantially retarded. The mean survival time of the rats on the restricted diet was increased by approximately 40 percent compared to control rats given free access to food. Dopamine receptor concentrations in striata of 24-month-old rats that had been on a restricted diet since weaning were 50 percent higher than those of control animals of the same age, and essentially comparable to 3- and 6-month-old control rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levin, P -- Janda, J K -- Joseph, J A -- Ingram, D K -- Roth, G S -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):561-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291993" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aging ; Animals ; Corpus Striatum/*metabolism ; *Diet ; Fasting ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-03
    Beschreibung: The antigen of a monoclonal antibody that is specific for cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnani, J L -- Brockhaus, M -- Smith, D F -- Ginsburg, V -- Blaszczyk, M -- Mitchell, K F -- Steplewski, Z -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- RR-05540/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):55-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209516" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/*immunology ; Antibodies, Neoplasm/*immunology ; Antibody Specificity ; Antigens, Neoplasm/*immunology/isolation & purification ; Cell Line ; Chromatography, Thin Layer ; Colonic Neoplasms/*immunology ; Gangliosides/*immunology/isolation & purification ; Humans ; Melanoma/immunology ; Neuraminidase/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Modulation of parallel fiber excitability by postsynaptically mediated changes in extracellular potassium (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-16
    Beschreibung: Field potentials and extracellular potassium concentration ([K+]o) were simultaneously monitored in the molecular layer of the rat cerebellar cortex during stimulation of the parallel fibers. The synaptic field potential elicited by stimulation was reduced by several methods. Reduction of synaptic field potentials was accompanied by a marked increase in the excitability of the parallel fibers. This change in excitability was related to the degree of extracellular K+ accumulation associated with parallel fiber stimulation. These findings support the proposal that increases in [K+]o associated with activity in postsynaptic elements can modulate the excitability of presynaptic afferent fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malenka, R C -- Kocsis, J D -- Ransom, B R -- Waxman, S G -- NS 15589/NS/NINDS NIH HHS/ -- NS-00473/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280695" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Afferent Pathways/*physiology ; Animals ; Calcium/physiology ; Cerebellar Cortex/*physiology ; Evoked Potentials ; Extracellular Space/physiology ; Male ; Manganese/pharmacology ; Membrane Potentials ; Potassium/*physiology ; Rats ; Rats, Inbred Strains ; Synapses/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-09-04
    Beschreibung: Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, T F -- Kowalchyk, J A -- AM 25861/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267695" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Division/*drug effects ; Cell Line ; Cricetinae ; Cyclic AMP/*pharmacology ; DNA/biosynthesis ; Growth Inhibitors/*pharmacology ; Mice ; Phosphodiesterase Inhibitors/pharmacology ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Electroconvulsive shock increases tyrosine hydroxylase activity in the brain and adrenal gland of the rat (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-06
    Beschreibung: A single application of electroconvulsive shock produced a rapid but short-lasting increase in tyrosine hydroxylase activity above control values in the rat adrenal medulla and striatum. After repeated electroconvulsive shock treatment (once per day for 7 days), tyrosine hydroxylase activity increased significantly in the locus ceruleus, nucleus of the tractus solitarius, hippocampus, cerebellum, and frontal cortex and remained elevated for 4 to 8 days. Adrenal tyrosine hydroxylase activity increased 1 day after the termination of repeated electroconvulsive shock treatments and remained elevated for at least 24 days, possibly reflecting the establishment of a new and higher steady-state level of catecholamine biosynthesis in the adrenal. These findings suggest that the persistent changes in tyrosine hydroxylase activity produced by repeated electroconvulsive shock may be a factor contributing to the long-lasting antidepressant effects of this treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masserano, J M -- Takimoto, G S -- Weiner, N -- NS 07927/NS/NINDS NIH HHS/ -- NS 09199/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):662-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117127" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenal Glands/*enzymology ; Animals ; Brain/*enzymology ; Corpus Striatum/enzymology ; *Electroshock ; Enzyme Induction ; Locus Coeruleus/enzymology ; Male ; Rats ; Rats, Inbred Strains ; Time Factors ; Tyrosine 3-Monooxygenase/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Human lupus inclusions and interferon (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-14
    Beschreibung: Raji cells, a human B lymphoblastoid cell line of Burkitt lymphoma origin, formed lupus inclusions when grown in a medium conditioned by the growth of Raji cells whose DNA thymidine residues had been unifilarly (single-strandedly) substituted with bromodeoxyuridine. Ultracentrifugation of this medium in excess of that required to remove Epstein-Barr virus and all other known mammalian viruses did not prevent the formation of the inclusions, and treatment of the conditioned medium with pronase destroyed the activity. These results demonstrate the presence of a protein that is secreted from bromodeoxyuridine-substituted Raji cells and is capable of inducing nonbromodeoxyuridine-substituted cells to form lupus inclusions. Interferon (100 units per milliliter) was found in the conditioned medium. Inclusions also formed in Raji cells grown in fresh medium supplemented with human leukocyte or fibroblast interferon (100 units per milliliter).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, S A -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):772-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6166984" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bromodeoxyuridine/*metabolism ; Burkitt Lymphoma ; Cell Line ; Culture Media ; Cytoplasmic Granules/ultrastructure ; DNA Replication ; Humans ; Interferons/*biosynthesis ; Lupus Erythematosus, Systemic/*pathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    Diameter of the cell-to-cell junctional membrane channels as probed with neutral molecules (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-31
    Beschreibung: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarzmann, G -- Wiegandt, H -- Rose, B -- Zimmerman, A -- Ben-Haim, D -- Loewenstein, W R -- CA 14464/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244653" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Chironomidae ; Fluorescent Dyes ; Glycopeptides/*metabolism ; Intercellular Junctions/*ultrastructure ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Oligosaccharides/*metabolism ; Protein Conformation ; Salivary Glands/*ultrastructure ; Species Specificity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    Tumor cell killing by phorbol ester--differentiated human leukemia cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-07
    Beschreibung: The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, J B -- 27070-02/PHS HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):655-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196085" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation/drug effects ; Cell Line ; *Cytotoxicity, Immunologic ; Humans ; Immunity, Cellular ; Leukemia, Experimental/immunology/*pathology ; Macrophages/cytology/*immunology ; Phorbols/*pharmacology ; Tetradecanoylphorbol Acetate/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Mesenchymal cells from the human embryonic palate are highly responsive to epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-31
    Beschreibung: An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoneda, T -- Pratt, R M -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):563-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017936" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Division/drug effects ; Cell Line ; DNA Replication/drug effects ; Embryo, Mammalian ; Epidermal Growth Factor/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Kinetics ; Organ Specificity ; Ornithine Decarboxylase/metabolism ; Palate/drug effects/*physiology ; Peptides/*pharmacology ; Pregnancy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-26
    Beschreibung: The ability of murine tumor cells to metastasize spontaneously from subcutaneous sites is positively correlated with the total sialic acid content of the cells in culture, the degree to which the sialic acid is exposed on the tumor cell surface, and, most strongly, with the degree of sialylation of galactosyl and N-acetylgalactosaminyl residues in cell surface glycoconjugates. These findings suggest that sialic acid on the cell surface may play a role in tumor cell metastasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yogeeswaran, G -- Salk, P L -- CA19312-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233237" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Membrane/*physiology ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Mice ; *Neoplasm Metastasis ; Neoplasms, Experimental/*physiopathology ; Sialic Acids/*analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Regulation of carcinogen metabolism in the rat ovary by the estrous cycle and gonadotropin (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-03-25
    Beschreibung: The activity of 7,12-dimethylbenz[a]anthracene hydroxylase in the rat ovary is several times higher in the proestrous phase of the estrous cycle than in the estrous and metestrous plus diestrous phases. Administration of gonadotropin leads to a similar increase in the capacity of the ovary to metabolize xenobiotics. This variation in the activity of 7,12-dimethylbenz[a]anthracene hydroxylase during the estrous cycle may be related to the marked changes in the incidence of ovarian cancer during menopause and in women taking contraceptive pills.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bengtsson, M -- Rydstrom, J -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681915" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Aryl Hydrocarbon Hydroxylases/*metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Epoxide Hydrolases/metabolism ; *Estrus ; Female ; Glutathione Transferase/metabolism ; Gonadotropins, Equine/*pharmacology ; Metestrus ; Ovary/*physiology ; Pregnancy ; Proestrus ; Quinone Reductases/metabolism ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Pimozide blocks establishment but not expression of amphetamine-produced environment-specific conditioning (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-17
    Beschreibung: Animals with a history of receiving daily injections of +-amphetamine in a specific environment showed a placebo effect (enhanced activity) when injected with saline and placed there; control animals with similar but dissociated drug histories and experience with the test chamber failed to show the effect. The dopamine receptor blocker pimozide antagonized the establishment of conditioning. However, the same dose of pimozide, when given to previously conditioned animals on the placebo test day, failed to antagonize the expression of conditioned activity. Thus, during conditioning dopaminergic neurons mediated a change that subsequently influenced behavior even when dopaminergic systems were blocked. Although schizophrenia may be related to hyperfunctioning of dopamine, neuroleptic drugs, which block dopamine receptors on their first administration, do not have therapeutic effects for a number of days. The results of the pimozide experiments may resolve this paradox.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beninger, R J -- Hahn, B L -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857251" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Conditioning (Psychology)/*drug effects/physiology ; Dextroamphetamine/antagonists & inhibitors/*pharmacology ; Humans ; Male ; Pimozide/*pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/physiology ; Reinforcement (Psychology) ; Schizophrenia/physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Direct in vivo monitoring of dopamine released from two striatal compartments in the rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-08
    Beschreibung: Microvoltammetric electrodes were used to monitor dopamine released in the caudate nucleus of the rat after electrical stimulation of the medial forebrain bundle. The time resolution of the technique is sufficient to determine in vivo concentration changes on a time scale of seconds. Direct evidence identifying the substance released as dopamine was obtained both voltammetrically and pharmacologically. Administration of alpha-methyl-p-tyrosine terminates the release of dopamine, although tissue stores of dopamine are still present. Thus there appears to be a compartment for dopamine storage that is not available for immediate release. This compartment appears to be mobilized by amfonelic acid, since administration of this agent after alpha-methyl-p-tyrosine returns the concentration of dopamine released by electrical stimulation to 75 percent of the original amount.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ewing, A G -- Bigelow, J C -- Wightman, R M -- KO 4 NS000356/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):169-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857277" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amphetamine/pharmacology ; Animals ; Caudate Nucleus/drug effects/*metabolism ; Dopamine/*metabolism ; Male ; Methyltyrosines/pharmacology ; Microelectrodes ; Naphthyridines/pharmacology ; Rats ; Rats, Inbred Strains ; alpha-Methyltyrosine
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    Scientist sues over genetically impure mice (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-27
    Beschreibung: Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R R -- Kuhar, M J -- Hester, L -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 27;220(4600):967-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302841" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine/*physiology ; Animals ; Autoradiography ; Axons/*physiology ; Cerebellum/physiology ; Corpus Striatum/physiology ; Hippocampus/physiology ; Mice ; Mice, Neurologic Mutants ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*physiology ; Receptors, Purinergic ; Retinal Ganglion Cells/physiology ; Synaptic Membranes/physiology ; Thalamus/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    High efficiency DNA-mediated transformation of primate cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-05
    Beschreibung: Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorman, C -- Padmanabhan, R -- Howard, B H -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Avian Sarcoma Viruses/genetics ; Cell Line ; Cercopithecus aethiops ; Cricetinae ; Cricetulus ; DNA, Recombinant/*metabolism ; Genetic Vectors ; HeLa Cells/metabolism ; Humans ; Mice ; Plasmids ; *Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: Long-term treatment of rats with atropine induced large increases in the numbers of muscarinic receptors and receptors for vasoactive intestinal polypeptide in the salivary glands. Since receptors for vasoactive intestinal polypeptide coexist with muscarinic receptors on the same neurons in this preparation, the results suggest that a drug that alters the sensitivity of one receptor may also affect the sensitivity of the receptor for a costored transmitter and in this way contribute to the therapeutic or side effects of the drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedlund, B -- Abens, J -- Bartfai, T -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):519-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132446" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Atropine/*pharmacology ; Gastrointestinal Hormones/*metabolism ; Male ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*drug effects ; Receptors, Muscarinic/analysis/*drug effects ; Salivary Glands/analysis/innervation ; Vasoactive Intestinal Peptide/analysis/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Honchar, M P -- Olney, J W -- Sherman, W R -- MH-14677/MH/NIMH NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- NS-05159/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301005" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Atropine/pharmacology ; Brain Chemistry/drug effects ; Chlorides/adverse effects ; Drug Interactions ; Humans ; Inositol/analogs & derivatives/analysis ; *Inositol Phosphates ; Lithium/*adverse effects ; Lithium Chloride ; Male ; Parasympathomimetics/*adverse effects ; Physostigmine/adverse effects ; Pilocarpine/adverse effects ; Rats ; Rats, Inbred Strains ; Seizures/*chemically induced ; Substance-Related Disorders/*etiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 23
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    Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-09
    Beschreibung: Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis. Both kappa genes and one lambda gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magrath, I -- Erikson, J -- Whang-Peng, J -- Sieverts, H -- Armstrong, G -- Benjamin, D -- Triche, T -- Alabaster, O -- Croce, C M -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1094-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316501" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/complications ; Antigens, Viral/analysis ; Burkitt Lymphoma/complications/*genetics ; Cell Line ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Epstein-Barr Virus Nuclear Antigens ; Herpesvirus 4, Human/analysis ; Homosexuality ; Humans ; Immunoglobulin Light Chains/*biosynthesis ; Immunoglobulin kappa-Chains/*biosynthesis ; Male ; Oncogenes
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 24
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    Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-25
    Beschreibung: Intracisternal injection of ovine corticotropin-releasing factor (CRF) into the pylorus-ligated rat or the rat with gastric fistula resulted in a dose-dependent inhibition of gastric secretion stimulated with pentagastrin or thyrotropin-releasing hormone. When injected into the lateral hypothalamus--but not when injected into the cerebral cortex--CRF suppressed pentagastrin-stimulated acid secretion. The inhibitory effect of CRF was blocked by vagotomy and adrenalectomy but not by hypophysectomy or naloxone treatment. These results indicate that CRF acts within the brain to inhibit gastric acid secretion through vagal and adrenal mechanisms and not through hypophysiotropic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tache, Y -- Goto, Y -- Gunion, M W -- Vale, W -- River, J -- Brown, M -- AM30110/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):935-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6415815" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenalectomy ; Animals ; Brain/*drug effects ; Cerebral Cortex/drug effects ; Corticotropin-Releasing Hormone/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Gastric Acid/*secretion ; Hypophysectomy ; Hypothalamus/drug effects ; Male ; Pentagastrin/antagonists & inhibitors ; Rats ; Rats, Inbred Strains ; Thyrotropin-Releasing Hormone/antagonists & inhibitors ; Vagotomy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-01
    Beschreibung: Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tannenbaum, G S -- Guyda, H J -- Posner, B I -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338593" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Body Weight/*drug effects ; Brain/drug effects/*physiology ; Eating/drug effects ; Growth Hormone/antagonists & inhibitors/blood/*physiology ; Insulin/blood/*pharmacology ; Male ; Peptides/*pharmacology ; Rats ; Rats, Inbred Strains ; Somatomedins/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 26
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    Potent interaction between glucocorticoids and growth hormone-releasing factor in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-05
    Beschreibung: Administration of dexamethasone significantly enhanced the pituitary growth hormone response to growth hormone-releasing factor in intact as well as adrenalectomized rats. Thus the inhibitory effects of glucocorticosteroids on somatic growth which involve an interaction of these steroids and growth hormone at a peripheral level may also involve a modification of pathways within the central nervous system that regulate normal growth hormone secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wehrenberg, W B -- Baird, A -- Ling, N -- AM-18811/AM/NIADDK NIH HHS/ -- HD 09690/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):556-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408735" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenalectomy ; Animals ; Dexamethasone/pharmacology ; Drug Interactions ; Glucocorticoids/*pharmacology ; Growth Hormone/blood/secretion ; Growth Hormone-Releasing Hormone/*pharmacology ; Male ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 27
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    DNA methylation decreases in aging but not in immortal cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-03
    Beschreibung: When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, V L -- Jones, P A -- 1-T32-CA09320/CA/NCI NIH HHS/ -- R01-GM30892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844925" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 5-Methylcytosine ; *Aging ; Animals ; Cell Division ; Cell Line ; Cricetinae ; Cytosine/analogs & derivatives/metabolism ; DNA/metabolism/*physiology ; Fibroblasts/metabolism ; Humans ; Mesocricetus ; Methylation ; Mice ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    Increased brain size and cellular content in infant rats treated with an opiate antagonist (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-16
    Beschreibung: From birth to day 21, rat offspring received daily injections of naltrexone at a dosage that blocked morphine-induced analgesia 24 hours a day. At 21 days, body, brain, and cerebellar weights of naltrexone-injected animals were 18, 11, and 5 percent greater than corresponding control weights. In addition, morphometric analysis of the cerebrum revealed a somatosensory cortex that was 18 percent thicker than that of the controls. The cerebellum of naltrexone-treated rats was 41 percent larger in total area and contained at least 70 percent more glial cells and 30 percent more granule neurons. Neurons derived prenatally were unaffected by drug treatment. These results show that naltrexone can stimulate body and brain growth in rats and suggest a role for the endorphin and opiate receptor system in development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zagon, I S -- McLaughlin, P J -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1179-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612331" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Newborn ; Body Weight/drug effects ; Brain/*drug effects/growth & development/ultrastructure ; Cerebellum/drug effects ; Morphine/*antagonists & inhibitors ; Naloxone/*analogs & derivatives ; Naltrexone/*pharmacology ; Neuroglia/drug effects ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; Somatosensory Cortex/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 29
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    Insulin receptor: evidence that it is a protein kinase (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-21
    Beschreibung: Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor. This subunit of the insulin receptor was also labeled with [alpha-32P]8-azidoadenosine 5'-triphosphate, a photoaffinity label for adenosine triphosphate binding sites. The identity of the 95,000-dalton band was confirmed in both cases by precipitation with a monoclonal antibody to the insulin receptor. These results suggest that the insulin receptor is itself a protein kinase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, R A -- Cassell, D J -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849137" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Cell Line ; Cells, Cultured ; Lymphocytes ; Molecular Weight ; Phosphoproteins/physiology ; Protein Kinases/*physiology ; Receptor, Insulin/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 30
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    Interrelated striated elements in vestibular hair cells of the rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Unusual fixation procedures revealed a series of interrelated striated organelles in type I and type II vestibular hair cells of the rat; these organelles seemed to be less well developed in cochlear hair cells. The findings suggest that contractile elements may play a role in sensory transduction in the inner ear, particularly in the vestibular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, M D -- Bourne, C -- New York, N.Y. -- Science. 1983 May 6;220(4597):622-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682246" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actins/physiology ; Animals ; Cell Membrane/ultrastructure ; Cytoskeleton/ultrastructure ; Hair Cells, Auditory/*ultrastructure ; Microscopy, Electron ; Organoids/ultrastructure ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 31
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    Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase inhibitor diisopropyl fluorophosphate, binding of tritiated acetylcholine in the cerebral cortex was decreased. However, after repeated administration of nicotine for 10 days, binding of tritiated acetylcholine in the cortex was increased. Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, R D -- Kellar, K J -- 507 RR05360-20/RR/NCRR NIH HHS/ -- GM07443/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):214-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828889" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcholine/metabolism ; Animals ; Brain/*physiology ; Brain Chemistry/drug effects ; Cerebral Cortex/analysis/physiology ; Isoflurophate/pharmacology ; Male ; Nicotine/metabolism/pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Cholinergic/*physiology ; Receptors, Nicotinic/analysis/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 32
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    Herpes simplex virus glycoprotein D: human monoclonal antibody produced by bone marrow cell line (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-08
    Beschreibung: Normal bone marrow cells from a donor positive for herpes simplex virus were transformed with Epstein-Barr virus. The resulting lymphoblastoid cell line has secreted immunoglobulin G1 of the kappa type continuously for 2 years. This immunoglobulin, detected both on the cell surface and in the cytoplasm, reacts with cells infected with herpes simplex virus. It defines an antigen that comigrates with the 55-kilodalton glycoprotein D of herpes simplex virus type 1 and neutralizes the infectivity of herpes simplex viruses 1 and 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seigneurin, J M -- Desgranges, C -- Seigneurin, D -- Paire, J -- Renversez, J C -- Jacquemont, B -- Micouin, C -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304881" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Antibodies, Monoclonal/*immunology ; B-Lymphocytes/immunology ; Bone Marrow/*immunology ; Bone Marrow Cells ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/immunology ; Simplexvirus/*immunology ; Viral Envelope Proteins ; Viral Proteins/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 33
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    Bovine x mouse hybridomas that secrete bovine immunoglobulin G1 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: The interspecific fusion of normal bovine lymphocytes with a nonsecreting mouse hybridoma produced stable cell lines secreting bovine immunoglobulins. One of these lines has continued to secrete immunoglobulin G1 (5 to 10 micrograms per milliliter) for over 16 months. The bovine x mouse hybrid cells can be expected to provide bovine monoclonal immunoglobulins for sequencing studies and for use as serological standards as well as to provide messenger RNA for cloning bovine immunoglobulin genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Srikumaran, S -- Guidry, A J -- Goldsby, R A -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):522-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403985" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/biosynthesis ; Cattle ; Cell Line ; Hybridomas/*immunology ; Immunoglobulin G/*biosynthesis/immunology/isolation & purification ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/immunology ; Immunoglobulin M/immunology ; Mice ; Radioimmunoassay
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    Serological visualization of interleukin 2 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: Interleukin 2, a lymphokine that acts as a second signal of cellular immune response by way of its action as a T-cell growth factor, was morphologically identified by immunoperoxidase staining. With the use of a monoclonal antibody to interleukin 2 and several complex-forming antisera, the lymphokine was readily distinguished in cytocentrifuge preparations of peripheral blood leukocytes stimulated with a T-cell mitogen. When preparations of cloned interleukin 2 producer and responder cells were stained by the same procedures, discrete patterns of both responder and producer cell phenotypes were revealed. Interleukin 2 producer T cells exhibited a characteristic intense, ringlike cytoplasmic staining, whereas the responder cells (as exemplified by interleukin 2-dependent cell lines) exhibited a less intensive, spotlike membrane staining. In addition, intense membrane localization of interleukin 2, reminiscent of potential capping phenomena, could be observed in stained preparations of cloned responder cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinmann, G -- Conlon, P -- Hefeneider, S -- Gillis, S -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344215" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/immunology ; Cell Line ; Humans ; Immunoenzyme Techniques ; Interleukin-2/*physiology ; Leukocytes/physiology ; Mice ; T-Lymphocytes/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 35
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    Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-16
    Beschreibung: A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil, an inhibitor of aldose reductase. Since the basement membrane thickening was ultrastructurally similar to that typical of diabetic retinopathy, it may indicate changes in vessel permeability and susceptibility to hemorrhage. Galactosemic rats should be useful models for studying basement membrane-related complications of diabetes and for examining the potential biochemical regulation of basement membrane synthesis by aldose reductase inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robison, W G Jr -- Kador, P F -- Kinoshita, J H -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612330" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Basement Membrane/*pathology ; Capillaries/pathology ; Diabetic Retinopathy/etiology ; Disease Models, Animal ; Galactosemias/drug therapy/*pathology ; Imidazoles/*therapeutic use ; *Imidazolidines ; Male ; Rats ; Rats, Inbred Strains ; Retinal Vessels/*pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-16
    Beschreibung: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 37
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    Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: The involvement of plasma fibronectin in phagocytosis of bacteria was investigated by testing the binding of fibronectin to several species of bacteria and by evaluating the ability of fibronectin to promote binding and endocytosis of two species of these bacteria by phagocytic cells. Fibronectin binds non-covalently to Gram-positive and Gram-negative bacteria and to yeast but did not appear to be necessary or sufficient for uptake of Staphylococcus aureus and Salmonella typhimurium by several different phagocytic cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van de Water, L -- Destree, A T -- Hynes, R O -- R01CA17007/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):201-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338594" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacteria/*metabolism ; Cell Line ; Cricetinae ; Endocytosis ; Fibronectins/*metabolism ; Humans ; Macrophages/physiology ; Mice ; Opsonin Proteins/physiology ; *Phagocytosis ; Rabbits ; Salmonella typhimurium/metabolism ; Sepsis/immunology ; Staphylococcus aureus/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 38
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    Single-channel fluctuations in bimolecular lipid membranes induced by rat olfactory epithelial homogenates (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-13
    Beschreibung: Chemosensitive single-channel fluctuations were observed to be induced in essentially solvent-free lipid bimolecular membranes by the addition of sonicated homogenates of rat olfactory epithelium. The chemosensitive channels were not observed when respiratory epithelium homogenates were used instead. Ionic selectivity is consistent with potassium ions as the charge carrier. These channels may be associated with the initial events of chemoreception in the rat olfactory epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vodyanoy, V -- Murphy, R B -- New York, N.Y. -- Science. 1983 May 13;220(4598):717-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301014" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anura ; Chemoreceptor Cells/physiology ; Epithelium/physiology ; Ion Channels/*drug effects ; Male ; Membranes/drug effects ; Olfactory Mucosa/*physiology ; Rats ; Rats, Inbred Strains ; Smell/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 39
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    Dopamine modulation of the effects of gamma-aminobutyric acid on substantia nigra pars reticulata neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: Studies were conducted to assess whether basal ganglia output neurons originating in the substantia nigra pars reticulata might be affected by dopamine released from dendrites of neighboring substantia nigra pars compacta neurons. Dopamine applied by iontophoresis increased the baseline firing rates of approximately half of the substantia nigra pars reticulata cells tested. The more significant finding, unrelated to the increase in firing, was the ability of dopamine to attenuate the inhibitory responses of these cells to iontophoretically applied gamma-aminobutyric acid. These findings suggest a role for dopamine as a neuromodulator and further suggest that it can act at sites beyond the striatum to modify transmission from the basal ganglia to motor nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waszcak, B L -- Walters, J R -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):218-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828891" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials/drug effects ; Animals ; Dopamine/*pharmacology ; Iontophoresis ; Male ; Neurons/*drug effects ; Norepinephrine/pharmacology ; Rats ; Rats, Inbred Strains ; Substantia Nigra/*drug effects ; gamma-Aminobutyric Acid/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 40
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    Effects of tyrosine administration on serum biopterin in normal controls and patients with Parkinson's disease (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-07
    Beschreibung: After administration of tyrosine, total concentration of biopterin, the cofactor for tyrosine hydroxylase, was increased in the striatum, adrenal glands, and serum of rats, and in the serum of humans. Serum biopterin is lower in patients with Parkinson's disease than in normal controls. After oral administration of tyrosine, the increase in serum biopterin concentration was smaller in patients with Parkinson's disease (less than twofold) than in healthy controls (three-to sevenfold). These results suggest that tyrosine may have a regulatory role in biopterin biosynthesis and that patients with Parkinson's disease may have some abnormality in the regulation of biopterin biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamaguchi, T -- Nagatsu, T -- Sugimoto, T -- Matsuura, S -- Kondo, T -- Iizuka, R -- Narabayashi, H -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849120" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administration, Oral ; Adrenal Glands/metabolism ; Alanine/pharmacology ; Animals ; Biopterin/*blood ; Corpus Striatum/metabolism ; Humans ; Injections, Intraperitoneal ; Liver/metabolism ; Male ; Parkinson Disease/*blood ; Pteridines/*blood ; Rats ; Rats, Inbred Strains ; Time Factors ; Tyrosine/administration & dosage/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 41
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    Adenosine 3',5'-monophosphate modulates thyrotropin receptor clustering and thyrotropin activity in culture (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: A biologically active rhodamine conjugate of thyrotropin binds at 4 degrees C to diffusely distributed membrane thyrotropin receptors which patch and become endocytosed into thyroid cells in a temperature-sensitive process. When the cells are first incubated with 8-bromo-cyclic adenosine monophosphate at 37 degrees C, the conjugate also binds to clustered receptors at 4 degrees C. Furthermore, 8-bromo-cyclic adenosine monophosphate reduces the amount of adenosine 3',5'-monophosphate (cyclic AMP) induced by thyrotropin. Hence, increased intracellular cyclic AMP induces receptor patching and reduces the concentration of cyclic AMP normally induced by thyrotropin. This suggests that cyclic AMP acts both as the second messenger of thyrotropin and also as the regulator of the level of thyrotropin receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Avivi, A -- Tramontano, D -- Ambesi-Impiombato, F S -- Schlessinger, J -- CA-25820/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272396" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 8-Bromo Cyclic Adenosine Monophosphate ; Animals ; Cell Line ; Cell Membrane/drug effects/metabolism ; Cyclic AMP/*analogs & derivatives/*metabolism/pharmacology ; Rats ; Receptors, Cell Surface/drug effects/*metabolism ; Receptors, Thyrotropin ; Thyroid Gland/metabolism ; Thyrotropin/*metabolism/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 42
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    Endogenous opiates and stress-induced eating (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-04
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antelman, S M -- Rowland, N -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1149-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302588" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; Endorphins/*physiology ; Feeding Behavior/drug effects/*physiology ; Humans ; Naloxone/pharmacology ; Rats ; Rats, Inbred Strains ; Stress, Psychological/*physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 43
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    Reduction in oocyte number following prenatal exposure to a diet high in galactose (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-04
    Beschreibung: When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Y T -- Mattison, D R -- Feigenbaum, L -- Fukui, H -- Schulman, J D -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1145-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302587" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dietary Carbohydrates/*physiology ; Female ; Fetus/drug effects/physiology ; Galactose/*pharmacology ; Maternal-Fetal Exchange ; Oocytes/drug effects/*physiology ; Ovum/*physiology ; Pregnancy ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 44
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    Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-03-06
    Beschreibung: The etiologic agent of Korean hemorrhagic fever has been propagated in a human cultured cell line derived from a carcinoma of the lung. The cells, described as type II, alveolar epithelial, support replication of the agent and successive passages. Antigen of the Korean hemorrhagic fever agent is readily detected in infected cells by means of direct or indirect fluorescent antibody techniques. Previous attempts to propagate this agent in vitro had been unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉French, G R -- Foulke, R S -- Brand, O A -- Eddy, G A -- Lee, H W -- Lee, P W -- New York, N.Y. -- Science. 1981 Mar 6;211(4486):1046-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6110243" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, Viral/analysis ; Cell Line ; Hantavirus/*growth & development/immunology ; Hemorrhagic Fever with Renal Syndrome/*microbiology ; Humans ; Pulmonary Alveoli/microbiology ; RNA Viruses/*growth & development
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 45
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    Detection of circulating metallothionein in rats injected with zinc or cadmium (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-13
    Beschreibung: Circulating metallothionein was measured by radioimmunoassay over a 13-day period in male Sprague-Dawley rats that received a sequence of three intraperitoneal injections (at 3-day intervals) of either 5 milligrams of zinc or 0.8 milligrams of cadmium per kilogram of body weight. These amounts of zinc and cadmium produced metallothionein concentrations in the range of 2 to 5 nanograms per milliliter of serum (zinc) and 2 to 15 nanograms per milliliter of serum (cadmium). In control rats given saline injections over the same period the metallothionein concentration ranged from 1 to 3 nanograms per milliliter of serum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garvey, J S -- Chang, C C -- ES 01629/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):805-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292012" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cadmium/*pharmacology ; Dose-Response Relationship, Drug ; Male ; Metalloproteins/*blood ; Metallothionein/*blood/immunology ; Radioimmunoassay ; Rats ; Rats, Inbred Strains ; Zinc/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 46
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    Somatic cell hybrids from frog lymphocytes and mouse myeloma cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-29
    Beschreibung: Stable somatic cell hybrids were obtained by fusing Xenopus lymphocytes with mouse myeloma cells. These hybrids contained one to four Xenopus chromosomes and expressed Xenopus gene products, one of which was a lymphocyte membrane protein of 85,000 daltons precipitated by a monoclonal antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hengartner, H -- Du Pasquier, L -- New York, N.Y. -- Science. 1981 May 29;212(4498):1034-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785884" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies ; Antibodies, Monoclonal ; Cell Line ; Clone Cells ; Genes ; Hybrid Cells/*physiology ; Lymphocytes/*physiology ; Membrane Proteins/biosynthesis ; Mice ; Molecular Weight ; Neoplasms, Experimental/physiopathology ; Plasmacytoma/*physiopathology ; Xenopus
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 47
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    Purified reduced nicotinamide adenine dinucleotide: responses to lactate dehydrogenase isozymes from three cell sources (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-01
    Beschreibung: Lactate dehydrogenase (LDH, E.C. 1.1.1.27) isozymes from three single-cell sources reacted differently with reduced nicotinamide adenine dinucleotide (NADH) purified to published chromatographic and spectrophotometric specifications and free of inhibitors of LDH, when compared with a commercial preparation of NADH. The activity of LDH-1, purified from rabbit erythrocytes, increased the most with inhibitor-free NADH; the next most stimulated were the LDH isozymes from a control hepatocyte line; but hardly responsive at all were the same isozymes from chemically transformed cells. Thus isozyme composition alone did not account for the range of responses to purified NADH. The commercial preparation of NADH used in these studies contains the Strandjord-Clayson inhibitors, the most potent group identified in NADH preparations relative to LDH activity. The results suggest that specific molecular differences in individual isozymes contribute to the differential response to the Strandjord-Clayson inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, A E -- Weiss, E R -- Byrne, S T -- El-Torkey, N M -- Margolis, S A -- New York, N.Y. -- Science. 1981 May 1;212(4494):553-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209551" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/enzymology ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Liver Neoplasms, Experimental/enzymology ; NAD/analysis/*metabolism ; Rabbits ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 48
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    Brain aging correlates: retardation by hormonal-pharmacological treatments (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-30
    Beschreibung: Mid-aged rats were either adrenalectomized and chronically maintained, or left intact and treated daily for a 9- to 10-month period with a potent analog of the peptide adrenocorticotropin (residues 4 to 9), which has some stimulant properties, or with the neural stimulant pentylenetetrazole. All three treatments reduced hippocampal morphologic correlates of brain aging (neuronal loss, glial reactivity). The pentylenetetrazole and peptide treatments also improved reversal learning. These results suggest that certain endogenous peptides, with stimulant properties, may also exert long-term, trophic effects on brain structure and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landfield, P W -- Baskin, R K -- Pitler, T A -- AG 01552/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):581-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270791" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenalectomy ; Adrenocorticotropic Hormone/*pharmacology ; *Aging ; Animals ; Brain/*physiology ; Hippocampus/cytology/physiology ; Learning/physiology ; Pentylenetetrazole/*pharmacology ; Peptide Fragments/*pharmacology ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-20
    Beschreibung: The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, R A -- Miller, L P -- Lovenberg, W -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):919-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117945" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aminohydrolases/*metabolism ; Animals ; Biopterin/analogs & derivatives/*metabolism ; Corpus Striatum/drug effects/*metabolism ; Dopamine/*metabolism ; GTP Cyclohydrolase/*metabolism ; Hydroxydopamines/pharmacology ; Male ; Pteridines/*metabolism ; Rats ; Rats, Inbred Strains ; Substantia Nigra/drug effects/metabolism ; Tyrosine 3-Monooxygenase/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 50
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    Dopamine receptor binding is increased in diabetic rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-27
    Beschreibung: The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lozovsky, D -- Saller, C F -- Kopin, I J -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1031-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6458088" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alloxan/pharmacology ; Animals ; Blood Glucose/metabolism ; Cell Membrane/metabolism ; Corpus Striatum/*metabolism ; Diabetes Mellitus, Experimental/drug therapy/*metabolism ; Insulin/therapeutic use ; Kinetics ; Male ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/drug effects/*metabolism ; Spiperone/metabolism ; Streptozocin/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 51
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    Hypothyroidism elicits electrophysiological noradrenergic subsensitivity in rat cerebellum (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-06
    Beschreibung: discharge rats of Purkinje neurons were compared in control and hypothyroid adult rats. Purkinje neurons in hypothyroid rats fired significantly faster and were less sensitive to iontophoretically applied norepinephrine than those in control rats. The subsensitivity of the Purkinje neurons appeared to be primarily due to an alteration in the beta-receptor--adenylate cyclase complex, because the sensitivity of these cells to locally applied N6-monobutyryl adenosine 3'-5'-monophosphate (N6 cyclic AMP) did not change significantly. The sensitivity of the Purkinje neurons to norepinephrine could be restored in hypothyroid rats by administration of triiodothyronine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marwaha, J -- Prasad, K N -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):675-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270792" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials/drug effects ; Adenylyl Cyclases/metabolism ; Adrenergic Fibers/*physiopathology ; Animals ; Cerebellum/*physiopathology ; Cyclic AMP/metabolism ; Hypothyroidism/*physiopathology ; Male ; Norepinephrine/*physiology ; Purkinje Fibers/physiopathology ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic/*physiology ; Receptors, Adrenergic, beta/*physiology ; Triiodothyronine/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 52
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    Owl monkey cell line (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, S J -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1214.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233214" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Aotus trivirgatus ; Cell Line ; Hodgkin Disease/*pathology ; Humans ; Phenotype
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 53
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    Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: Inhibiting protein synthesis by incubating C6-2B rat astrocytoma cells with cycloheximide or emetine for periods up to 24 hours caused a progressive decrease in the accumulation of adenosine 3',5'-monophosphate (cyclic AMP) when the cells were challenged for 30 minutes with 100 microM forskolin. In contrast, cholera toxin-stimulated (6 nM, 3 hours) cyclic AMP accumulation was not diminished in cycloheximide-treated cells, and cyclic AMP was only minimally diminished in response to a 30-minute challenge with 10 microM (-)-isoproterenol. These experiments suggest the presence of a previously unrecognized cyclase component, which is essential for forskolin-stimulated cyclic AMP accumulation and has a shorter half-life than the beta-adrenergic receptor, the guanine nucleotide regulatory proteins, or the cyclase catalytic component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brooker, G -- Pedone, C -- Barovsky, K -- HL 06330/HL/NHLBI NIH HHS/ -- HL 28940/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1169-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6190226" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Astrocytoma/metabolism ; Cell Line ; Cholera Toxin/pharmacology ; Colforsin ; Cyclic AMP/*biosynthesis/physiology ; Cycloheximide/pharmacology ; Dichlororibofuranosylbenzimidazole/pharmacology ; Diterpenes/*pharmacology ; Emetine/pharmacology ; Isoproterenol/pharmacology ; *Protein Biosynthesis ; RNA/biosynthesis ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 54
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    Ethanol modulation of opiate receptors in cultured neural cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-16
    Beschreibung: The mouse neuroblastoma-rat glioma hybrid cell line NG108-15 was used to study the acute and chronic interaction of ethanol with intact neural cells. In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn. High concentrations of ethanol (200 mM) increased opiate binding after 18 to 24 hours, whereas lower concentrations (25 to 50 mM) produced similar changes after 2 weeks. This model system has potential for exploring the cellular and molecular mechanisms underlying ethanol intoxication, tolerance, and withdrawal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charness, M E -- Gordon, A S -- Diamond, I -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316506" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Dose-Response Relationship, Drug ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Ethanol/*pharmacology ; Glioma ; Hybrid Cells ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Rats ; Receptors, Opioid/*drug effects/metabolism ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 55
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    Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-27
    Beschreibung: The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eva, A -- Aaronson, S A -- New York, N.Y. -- Science. 1983 May 27;220(4600):955-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302839" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; DNA Restriction Enzymes ; DNA, Neoplasm/genetics ; Fibrosarcoma/chemically induced/*genetics ; Humans ; Methylcholanthrene/*pharmacology ; Mice ; Oncogenes/*drug effects ; Retroviridae/genetics ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 56
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    Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-25
    Beschreibung: Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine receptor supersensitivity after a unilateral lesion of the substantia nigra. The authors report that this effect of transplantation is specific to grafts of substantia nigra. They also report that, in conjunction with the decrease in motor asymmetry, these grafts cause postsynaptic dopaminergic binding sites to return to normal density as measured by tritiated spiroperidol autoradiography. Thus, in animals with brain lesions, grafts of substantia nigra produce a long-term alteration in the functional status of host brain cell receptors that is associated with a reduction in the behavioral deficit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Ko, G N -- Niehoff, D L -- Kuhar, M J -- Hoffer, B J -- Olson, L -- Cannon-Spoor, H E -- Morihisa, J M -- Wyatt, R J -- MH-00289/MH/NIMH NIH HHS/ -- MH-25951/MH/NIMH NIH HHS/ -- NS-09199/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):937-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635666" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Apomorphine/pharmacology ; Autoradiography ; Denervation ; Dextroamphetamine/pharmacology ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/*metabolism ; Spiperone/metabolism ; Substantia Nigra/*transplantation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 57
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    Shark cartilage contains inhibitors of tumor angiogenesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-16
    Beschreibung: Shark cartilage contains a substance that strongly inhibits the growth of new blood vessels toward solid tumors, thereby restricting tumor growth. The abundance of this factor in shark cartilage, in contrast to cartilage from mammalian sources, may make sharks an ideal source of the inhibitor and may help to explain the rarity of neoplasms in these animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, A -- Langer, R -- EY04002/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1185-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6193581" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cartilage/*physiology ; Cell Line ; Cornea ; Neoplasms/*blood supply ; *Neovascularization, Pathologic ; Rabbits ; Sharks
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 58
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    Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-23
    Beschreibung: The plasma membranes of hamster, mouse, and human tumor cell lines that display multiple resistance to drugs were examined by gel electrophoresis and immunoblotting. In every case, increased expression of a 170,000-dalton surface antigen was found to be correlated with multidrug resistance. This membrane component is of identical molecular size and shares some immunogenic homology with the previously characterized P-glycoprotein of colchicine-resistant Chinese hamster ovary cells. This finding may have application to cancer therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kartner, N -- Riordan, J R -- Ling, V -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1285-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6137059" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Membrane Permeability ; *Drug Resistance ; Glycoproteins/immunology/*physiology ; Membrane Proteins/*physiology ; Molecular Weight ; P-Glycoprotein
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 59
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    Phorbol ester receptors: autoradiographic identification in the developing rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-02
    Beschreibung: Autoradiography with 3H-labeled phorbol dibutyrate was used for the light microscopic detection of phorbol ester receptors in rat fetuses. In 15- and 18-day fetuses, as well as in adult rats, receptors were found to be concentrated in the central nervous system. The localization of receptors in the ventral marginal zone of the fetal neural tube, the lens of the eye, and other sites suggests a role for phorbol ester receptors in cellular process extension and cell-cell interaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, K M -- Gould, R J -- Oster-Granite, M L -- Gearhart, J D -- Snyder, S H -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):1036-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316499" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Autoradiography ; Brain/embryology ; Brain Chemistry ; *Caenorhabditis elegans Proteins ; Carrier Proteins ; Cell Communication ; Cell Division ; Central Nervous System/analysis/*embryology ; Eye/embryology ; Fetus/*analysis ; Intestines/embryology ; Lens, Crystalline/embryology ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/*metabolism ; Phorbols/*metabolism ; *Protein Kinase C ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*analysis ; *Receptors, Drug
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Dissections and reconstructions of genes and chromosomes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berg, P -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):296-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264595" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Chromosomes/*physiology/ultrastructure ; DNA Restriction Enzymes ; DNA, Recombinant ; DNA, Viral/genetics ; *Genes ; Histones ; Humans ; Plasmids ; RNA, Messenger/genetics ; Simian virus 40/genetics ; Transduction, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 61
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    DNA synthesis in cultured adult cardiocytes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-30
    Beschreibung: Trypsin-dissociated atrial cardiocytes from adult rats were exposed to [3H]thymidine for sequential 24-hour periods from day 2 to day 12 of culture. On day 3 and each day thereafter, cells were prepared for ultrastructural radioautography and examined with an electron microscope. Maximal incorporation occurred on day 5, when 63 percent of the cardiocytes were labeled. Mitotic activity was never present in more than 0.5 percent of the cardiocytes examined. Incorporation of [3H]thymidine and mitosis occurred only in immature cardiocytes characterized by subsarcolemmal primary filaments and Z bands with or without specific granules; more mature cardiocytes were never labeled.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantin, M -- Ballak, M -- Beuzeron-Mangina, J -- Anand-Srivastava, M B -- Tautu, C -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):569-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291996" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Autoradiography ; Cell Division ; Cells, Cultured ; DNA/*biosynthesis ; Female ; Mitosis ; Myocardium/*cytology ; Rats ; Rats, Inbred Strains ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 62
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    Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: An animal model of tardive dyskinesia was used to evaluate the potential antidyskinetic properties of the neuropeptide L-prolyl-L-leucyl-glycinamide (PLG). In rats, PLG administered concurrently with the neuroleptic drug haloperidol or chlorpromazine antagonized the enhancement of specific [3H]spiroperidol binding in the striatum that is associated with long-term neuroleptic treatment. The results are discussed in relation to a possible functional coupling of the putative PLG receptor with neuroleptic-dopamine receptor complex and clinical implications for tardive dyskinesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiu, S -- Paulose, C S -- Mishra, R K -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1261-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117947" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Butyrophenones/*metabolism ; Chlorpromazine/*pharmacology ; Corpus Striatum/*metabolism ; Haloperidol/*pharmacology ; Kinetics ; MSH Release-Inhibiting Hormone/*pharmacology ; Male ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/drug effects/*metabolism ; Spiperone/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 63
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    Hydra mesoglea: a model for investigating epithelial cell--basement membrane interactions (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-16
    Beschreibung: Isolated hydra mesoglea served as a suitable substrate for the attachment and spreading of hydra cells in vitro, irrespective of the species tested. Hydra cells did not attach and spread on substrates typically used for culturing mammalian cells. Mammalian and Drosophila cells attached and spread on plastic culture dishes but not on isolated mesoglea. Xenopus epithelial cells spread on both plastic and mesoglea. Because of the similarities of hydra mesoglea to vertebrate basement membranes, suggestions are offered for using mesoglea to study the interactions of epithelial cells with their basement membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Day, R M -- Lenhoff, H M -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):291-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444468" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Basement Membrane/physiology ; Biological Evolution ; Cell Adhesion ; Cell Line ; Epithelial Cells ; Extracellular Space/physiology ; Hydra/*cytology ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 64
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    Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-04
    Beschreibung: The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kazmers, I S -- Mitchell, B S -- Dadonna, P E -- Wotring, L L -- Townsend, L B -- Kelley, W N -- AM 19045/AM/NIADDK NIH HHS/ -- CA 26032/CA/NCI NIH HHS/ -- CA 26284/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1137-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795718" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): B-Lymphocytes/enzymology ; Cell Line ; Deoxyguanosine/pharmacology ; Guanosine/*analogs & derivatives/pharmacology ; Humans ; Kinetics ; Pentosyltransferases/*antagonists & inhibitors ; Purine-Nucleoside Phosphorylase/*antagonists & inhibitors ; T-Lymphocytes/drug effects/*enzymology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 65
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    Plasminogen activator release at the neuronal growth cone (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-09-25
    Beschreibung: The site of plasminogen activator release by differentiated neuroblastoma clonal cell lines was determined with a fibrin overlay assay. Release of plasminogen activator was seen at the growth cone in 72 percent of the cells bearing neurites. For 21 percent of these cells the growth cone was the predominant or exclusive site of this enzyme activity. Selective release of protease at the "trailblazing" tip of the neurite may be important in neuron migration and neurite growth in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krystosek, A -- Seeds, N W -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1532-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7197054" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; Cell Line ; *Cell Movement ; Cytochalasin B/pharmacology ; Fibroblasts/metabolism ; Mice ; Neuroblastoma ; Neurons/cytology/*enzymology ; Plasminogen Activators/*metabolism/secretion ; Secretory Rate/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 66
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    Cerebral cortex responds rapidly to thyroid hormones (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-30
    Beschreibung: In rats subjected to thyroidectomy there was a two- to fourfold increase in cerebral cortex iodothyronine 5'-deiodinase activity within 24 hours. This increase was prevented by thyroxine replacement. The increased cortical 5'-deiodinase in chronically hypothyroid rats was normalized within 4 hours by a single intravenous injection of triiodothyronine. These results indicate that the adult central nervous system can give a very rapid biochemical response to thyroid hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leonard, J L -- Kaplan, M M -- Visser, T J -- Silva, J E -- Larsen, P R -- AM00727/AM/NIADDK NIH HHS/ -- AM18616/AM/NIADDK NIH HHS/ -- AM25340/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):571-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291997" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cerebral Cortex/*enzymology ; Iodide Peroxidase/*metabolism ; Liver/metabolism ; Male ; Peroxidases/*metabolism ; Rats ; Rats, Inbred Strains ; Thyroidectomy ; Thyroxine/*metabolism ; Time Factors ; Triiodothyronine/*metabolism ; Triiodothyronine, Reverse/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 67
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    High levels of intracellular bombesin characterize human small-cell lung carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moody, T W -- Pert, C B -- Gazdar, A F -- Carney, D N -- Minna, J D -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272398" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/analysis ; Bombesin/*analysis ; Carcinoma, Small Cell/*analysis ; Carcinoma, Squamous Cell/analysis ; Cell Line ; Humans ; Lung Neoplasms/*analysis ; Mesothelioma/analysis ; Peptides/*analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Intraventricular calcitonin inhibits gastric acid secretion (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-11-06
    Beschreibung: Parenteral and intracerebroventricular administration of calcitonin in rats resulted in the suppression of gastric acid secretion. This suppression also occurred in rats with insulin-induced hypoglycemia and after the administration of thyrotropin-releasing hormone. Intracerebroventricularly administered calcitonin was 1000 times more effective than parenterally administered calcitonin in suppressing gastric acid secretion. Calcitonin also inhibited the development of stress-induced ulcers in rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morley, J E -- Levine, A S -- Silvis, S E -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):671-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292006" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/*drug effects ; Calcitonin/administration & dosage/*pharmacology ; Gastric Juice/*secretion ; Injections, Intraventricular ; Male ; Peptic Ulcer/etiology ; Rats ; Rats, Inbred Strains ; Stress, Physiological/complications
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 69
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    Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-30
    Beschreibung: Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollard, M -- Luckert, P H -- CA 00295/CA/NCI NIH HHS/ -- CA 15957/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):558-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291992" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dimethylnitrosamine/*analogs & derivatives/antagonists & inhibitors ; Indomethacin/*pharmacology ; Intestinal Neoplasms/*chemically induced ; Male ; Neoplasms, Experimental/chemically induced ; Rats ; Rats, Inbred Strains ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 70
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    Alcohol-induced spasms of cerebral blood vessels: relation to cerebrovascular accidents and sudden death (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Ethyl alcohol produced graded contractile responses in rat cerebral arterioles and venules in vivo and in isolated canine basilar and middle cerebral arteries at a concentration range (10 to 500 milligrams per deciliter) which parallels that needed for its graded effects of euphoria, mental haziness, muscular incoordination, stupor, and coma in humans. Two specific calcium antagonists, nimodipine and verapamil, prevented or reversed the alcohol-induced cerebrovasospasm and thus may prove valuable in treating the hypertension and stroke observed in heavy users of alcohol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altura, B M -- Altura, B T -- Gebrewold, A -- DA02339/DA/NIDA NIH HHS/ -- HL29600/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):331-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836278" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cerebral Arteries/drug effects ; Cerebrovascular Circulation/drug effects ; Cerebrovascular Disorders/*chemically induced ; Death, Sudden/*etiology ; Dogs ; Ethanol/*adverse effects ; Humans ; Ischemic Attack, Transient/*chemically induced ; Male ; Rats ; Rats, Inbred Strains ; Vasoconstriction/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 71
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    Detection of antibodies to herpes simplex virus with a continuous cell line expressing cloned glycoprotein D (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-04
    Beschreibung: The gene for glycoprotein D of herpes simplex virus type 1 (HSV-1) was expressed in stable mammalian cell lines. Glycoprotein D produced in these cells has a number of antigenic determinants in common with the native glycoprotein. Cell lines expressing glycoprotein D were used in an enzyme-linked immunosorbent assay to detect human antibodies to glycoprotein D. This strategy should prove useful in determining the extent to which the immune response to HSV-1 is directed toward glycoprotein D.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berman, P W -- Dowbenko, D -- Lasky, L A -- Simonsen, C C -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):524-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6312563" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibodies, Viral/*analysis ; Base Sequence ; Cell Line ; Clone Cells ; DNA Restriction Enzymes ; DNA, Viral/genetics ; Enzyme-Linked Immunosorbent Assay ; *Genes ; *Genes, Viral ; Humans ; Plasmids ; Simplexvirus/genetics/*immunology ; Tetrahydrofolate Dehydrogenase/genetics ; *Viral Envelope Proteins ; Viral Proteins/*genetics/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 72
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    Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-14
    Beschreibung: Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- McIsaac, R M -- Chen, L B -- CA22427/CA/NCI NIH HHS/ -- CA29793/CA/NCI NIH HHS/ -- CA33847/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):169-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623064" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carcinoma/*drug therapy ; Carcinoma, Ehrlich Tumor/*drug therapy ; Cell Line ; Deoxyglucose/therapeutic use ; Drug Synergism ; Drug Therapy, Combination ; Energy Metabolism/drug effects ; Mice ; Mitochondria/drug effects ; Rhodamine 123 ; Rhodamines/*therapeutic use ; Urinary Bladder Neoplasms/*drug therapy ; Xanthenes/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 73
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    Endogenous pyrogen activity in human plasma after exercise (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cannon, J G -- Kluger, M J -- AI 13878/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):617-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836306" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; Body Temperature/drug effects ; Female ; Humans ; *Interleukin-1 ; Iron/blood ; Leukocytes/physiology ; Male ; Molecular Weight ; *Physical Exertion ; Proteins/physiology ; Pyrogens/blood/*metabolism ; Rats ; Rats, Inbred Strains ; Zinc/blood
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 74
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    Transcriptional regulation of globin gene expression in the human erythroid cell line K562 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-17
    Beschreibung: The effect of hemin on the rate of synthesis and the level of globin messenger RNA's in the human erythroid cell line K562 was examined by means of cloned hybridization probes specific for each of the human embryonic, fetal, and adult globin genes. Hemin increases both the rate of transcription and the level of accumulation of zeta-, epsilon-, gamma-, and alpha-globin messenger RNA's by a factor of 3 to 5. Thus, hemin induction of globin gene expression in K562 cells is at the level of transcription.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charnay, P -- Maniatis, T -- HL278989/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1281-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6574602" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Erythroblasts/*metabolism ; Erythrocytes/*metabolism ; *Gene Expression Regulation/drug effects ; Globins/*genetics ; Hemin/pharmacology ; Humans ; Leukemia, Myeloid/metabolism ; RNA, Messenger/biosynthesis/genetics ; *Transcription, Genetic/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 75
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    Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-09
    Beschreibung: Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by anti-Tac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clapham, P -- Nagy, K -- Cheingsong-Popov, R -- Exley, M -- Weiss, R A -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1125-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316502" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, Surface/analysis ; Antigens, Viral/analysis ; Cell Line ; Cell Transformation, Viral ; Cell-Free System ; Deltaretrovirus/*growth & development/immunology/ultrastructure ; Humans ; Interleukin-2/metabolism ; Microscopy, Electron ; T-Lymphocytes/immunology ; *Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 76
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    Local cerebral blood flow increases during auditory and emotional processing in the conscious rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-05
    Beschreibung: Local cerebral blood flow was measured in rats by the 14C-labeled iodoantipyrine technique with quantitative autoradiography during the processing of environmental stimuli. Presentation of a tone increased blood flow in the auditory but not the visual pathway. When the animal had previously been conditioned to fear the tone, blood flow additionally increased in the hypothalamus and amygdala. Local cerebral blood flow can thus be used to detect patterns of cerebral excitation associated with transient (30- to 40-second) mental events in experimental animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉LeDoux, J E -- Thompson, M E -- Iadecola, C -- Tucker, L W -- Reis, D J -- HL 18974/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):576-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867731" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acoustic Stimulation ; Amygdala/blood supply ; Animals ; Autoradiography ; Brain/*blood supply/physiology ; Consciousness/physiology ; Emotions/*physiology ; Hearing/*physiology ; Hypothalamus/blood supply ; Male ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 77
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    L-tryptophan: a common denominator of biochemical and neurological events of acute hepatic porphyria? (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-02
    Beschreibung: Hepatic porphyrias are disorders of heme synthesis characterized by genetically determined lesions of one of the key enzymes of heme synthesis. In carriers of such lesions, several factors (drugs, environmental chemicals, or diet) precipitate acute and often fatal attacks of neurologic dysfunction, which are promptly relieved by intravenous infusion of heme. However, the mechanism of such heme-induced amelioration remains elusive. To probe this mechanism, the biochemical events triggered by acute hepatic heme deficiency were examined in an animal model of chemically induced porphyria. Acute hepatic heme depletion in porphyric rats was found to impair hepatic tryptophan pyrrolase activity which, in turn, elevated tryptophan and 5-hydroxytryptamine turnover in the brain. These alterations in porphyric rats were dramatically reversed by parenteral heme administration. These findings suggest that increased tryptophan and 5-hydroxytryptamine in the nervous system may be responsible for the neurologic dysfunctions observed in humans with acute attacks of hepatic porphyria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Litman, D A -- Correia, M A -- AM-26506/AM/NIADDK NIH HHS/ -- AM-26743/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):1031-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648517" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/*metabolism ; Heme/*deficiency/pharmacology ; Liver/enzymology ; Liver Diseases/complications/*metabolism ; Male ; Nervous System Diseases/etiology ; Porphyrias/complications/*metabolism ; Rats ; Rats, Inbred Strains ; Serotonin/metabolism ; Tryptophan/*metabolism ; Tryptophan Oxygenase/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 78
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    Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: After transport in the blood and implantation in the microcirculation, metastatic tumor cells must invade the vascular endothelium and underlying basal lamina. Mouse B16 melanoma sublines were used to determine the relation between metastatic properties and the ability of the sublines to degrade enzymatically the sulfated glycosaminoglycans present in the extracellular matrix of cultured vascular endothelial cells. Highly invasive and metastatic B16 sublines degraded matrix glycosaminoglycans faster than did sublines of lower metastatic potential. The main products of this matrix degradation were heparan sulfate fragments. Intact B16 cells (or their cell-free homogenates) with a high potential for lung colonization degraded purified heparan sulfate from bovine lung at higher rates than did B16 cells with a poor potential for lung colonization. Analysis of the degradation fragments indicated that B16 cells have a heparan sulfate endoglycosidase. Thus the abilities of B16 melanoma cells to extravasate and successfully colonize the lung may be related to their capacities to degrade heparan sulfate in the walls of pulmonary blood vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakajima, M -- Irimura, T -- Di Ferrante, D -- Di Ferrante, N -- Nicolson, G L -- R01-AM-26482/AM/NIADDK NIH HHS/ -- R01-CA-28867/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):611-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6220468" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Glycosaminoglycans/*metabolism ; Glycoside Hydrolases/metabolism ; Heparitin Sulfate/*metabolism ; Melanoma/enzymology/*physiopathology ; Mice ; *Neoplasm Invasiveness ; *Neoplasm Metastasis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 79
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    Fetal brain transplant: reduction of cognitive deficits in rats with frontal cortex lesions (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-29
    Beschreibung: Frontal cortex and cerebellar tissue from fetal rats was implanted into the damaged frontal cortex of adults. Cognitive deficits in spatial alternation learning that follow bilateral destruction of medial frontal cortex were reduced in rats with frontal cortex implants but not in those with implants of cerebellum. Histological evaluation showed that connections were made between the frontal cortex implants and host brain tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Labbe, R -- Firl, A Jr -- Mufson, E J -- Stein, D G -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):470-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6683427" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal ; Cerebellum/*transplantation ; Cerebral Cortex/injuries/*transplantation ; Cognition Disorders/*physiopathology ; Fetus/*surgery ; Humans ; Male ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 80
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    A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Gal alpha (1 leads to 4)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide]. The antibody demonstrated a strict steric specificity since it did not react with globoisotriaosylceramide [Gal alpha (1 leads to 3)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide], the positional isomer of the antigen associated with the Burkitt lymphoma. Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nudelman, E -- Kannagi, R -- Hakomori, S -- Parsons, M -- Lipinski, M -- Wiels, J -- Fellous, M -- Tursz, T -- CA 19224/CA/NCI NIH HHS/ -- CA 20026/CA/NCI NIH HHS/ -- GM 23100/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/*immunology ; Antigens, Neoplasm/*immunology ; Burkitt Lymphoma/*immunology ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/immunology ; Globosides/*immunology ; Glycosphingolipids/*immunology ; Humans ; Rabbits ; Rats ; *Trihexosylceramides
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 81
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    Suppressor T cell action inhibits the expression of an excluded immunoglobulin gene (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: Cells of the murine plasmacytoid line MOPC-315 synthesize two distinct immunoglobulin light chains: a normal lambda II protein, which is incorporated into secretory and surface-bound immunoglobulin, and a truncated, nonfunctional lambda I protein found only in the cytoplasm. Idiotype-specific suppressor T lymphocytes selectively inhibit the expression of both lambda II- and lambda I-specific messenger RNA by MOPC-315 cells. This finding demonstrates that phenotypically excluded light chain genes can be subject to immunoregulatory control and suggests that the expression of divergent lambda isotypes may be coordinately regulated in immunoglobulin-secreting cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parslow, T G -- Milburn, G L -- Lynch, R G -- Granner, D K -- AM25295/AM/NIADDK NIH HHS/ -- CA28848/CA/NCI NIH HHS/ -- CA32275/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1389-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6222474" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; *Gene Expression Regulation ; Immunoglobulin Light Chains/genetics ; Immunoglobulin lambda-Chains/genetics ; Immunoglobulins/*genetics ; Mice ; Mice, Inbred BALB C ; Plasmacytoma/genetics/immunology ; RNA, Messenger/biosynthesis ; T-Lymphocytes, Regulatory/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 82
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    Evidence for the recessive nature of cellular immortality (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-02
    Beschreibung: Fusion of immortal cell lines with normal human fibroblasts or certain other immortal cell lines yields hybrids having limited division potential. Cellular immortality was found to be a recessive phenotype in hybrids. It was also found that at least two separate events in the normal cell genome can result in immortality. In fusions involving certain immortal parent cells, these events can be complemented to result in hybrids with finite division capacity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pereira-Smith, O M -- Smith, J R -- AG 03262/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):964-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879195" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Cell Division ; Cell Line ; *Cell Survival ; Cells, Cultured ; Genes, Recessive ; Humans ; Hybrid Cells/*physiology ; Phenotype
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 83
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    Isolation and transmission of human retrovirus (human t-cell leukemia virus) (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-18
    Beschreibung: Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popovic, M -- Sarin, P S -- Robert-Gurroff, M -- Kalyanaraman, V S -- Mann, D -- Minowada, J -- Gallo, R C -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):856-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6600519" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Cells, Cultured ; Female ; Humans ; Leukemia/*microbiology ; Male ; Retroviridae/growth & development/*isolation & purification ; T-Lymphocytes/*microbiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 84
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    Evidence for olfactory function in utero (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-29
    Beschreibung: Pregnant rats received 2-[14C]deoxy-D-glucose (2DG) intravenously on the last day of gestation, and their fetuses were delivered 1 hour later by cesarean section. Fetal brains showed high 2DG uptake spread throughout the accessory olfactory bulb and little or no differential uptake in the main olfactory bulb. These findings demonstrate that functional activity occurs in the accessory olfactory bulb in utero and suggest that the accessory olfactory system may be the pathway by which fetal rats detect the odor quality of their intrauterine milieu.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, P E -- Stewart, W B -- Greer, C A -- Shepherd, G M -- F32-NS06978/NS/NINDS NIH HHS/ -- NS 16993/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):478-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867725" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Autoradiography ; Brain/radionuclide imaging ; Deoxyglucose/metabolism ; Female ; Fetus/*physiology ; Olfactory Bulb/physiology/radionuclide imaging ; Pregnancy ; Rats ; Rats, Inbred Strains ; Smell/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 85
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    Correlation of glucocorticoid receptor binding sites on MMTV proviral DNA with hormone inducible transcription (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-23
    Beschreibung: Steroid hormones, when complexed to their receptors, recognize and bind specific DNA sequences and subsequently induce increased levels of transcription. The mechanisms of steroid hormone action were analyzed by constructing chimeric DNA molecules from portions of mouse mammary tumor virus envelope and long terminal repeat (LTR) regions ligated to the thymidine kinase (tk) gene of herpes simplex virus. This construction allowed the tk gene to be expressed in a hormone-responsive fashion upon transfection into Ltk- cells. Comparison of transcription data with in vitro binding data showed that hormone-responsive transcription can be directly correlated to the presence of steroid hormone receptor binding sites on the DNA. There are at least two such receptor binding sites in the LTR region, one between -202 and -137 and another between -137 and -50 base pairs from the RNA cap site, as well as a site near the 5' end of the envelope region. These results strengthen the hypothesis that steroid-receptor complexes regulate genes primarily by binding to DNA sites near the promoter region and thereby modulate transcription.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfahl, M -- McGinnis, D -- Hendricks, M -- Groner, B -- Hynes, N E -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1341-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318311" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding Sites ; Cell Line ; Chimera ; DNA, Viral/*metabolism ; Glucocorticoids/metabolism/*pharmacology ; Mammary Tumor Virus, Mouse/*analysis ; Mice ; Receptors, Glucocorticoid/*metabolism ; Receptors, Steroid/*metabolism ; Repetitive Sequences, Nucleic Acid ; Transcription, Genetic/*drug effects ; Transfection ; Triamcinolone Acetonide/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 86
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    1,25-dihydroxyvitamin D3 receptors in human leukocytes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-16
    Beschreibung: A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Provvedini, D M -- Tsoukas, C D -- Deftos, L J -- Manolagas, S C -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310748" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): B-Lymphocytes/analysis ; Cell Line ; Humans ; Leukemia/analysis ; Leukocytes/*analysis ; Lymphocyte Activation ; Monocytes/analysis ; Receptors, Calcitriol ; Receptors, Steroid/*analysis ; T-Lymphocytes/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 87
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    Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-29
    Beschreibung: Insulin directly inhibits protein phosphorylation in isolated rat liver nuclear envelopes. In the present studies, an antiserum to insulin receptor as well as the plant lectins concanavalin A and phytohemagglutinin mimicked insulin action in isolated nuclear envelopes. These studies suggest that insulin and agents that mimic it may directly regulate nuclear functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Purrello, F -- Burnham, D B -- Goldfine, I D -- AM 06659/AM/NIADDK NIH HHS/ -- AM 26667/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):462-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6346487" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Concanavalin A/pharmacology ; Female ; Immune Sera ; Insulin/*pharmacology ; Lectins/*pharmacology ; Nuclear Envelope/*drug effects/metabolism ; Phosphorylation ; Phytohemagglutinins/pharmacology ; Rats ; Rats, Inbred Strains ; Receptor, Insulin/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 88
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    Physiological correlates of prolonged sleep deprivation in rats (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-08
    Beschreibung: The issue of whether sleep is physiologically necessary has been unresolved because experiments that reported deleterious effects of sleep deprivation did not control for the stimuli used to prevent sleep. In this experiment, however, experimental and control rats received the same relatively mild physical stimuli, but stimulus presentations were timed to reduce sleep severely in experimental rats but not in controls. Experimental rats suffered severe pathology and death; control rats did not.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rechtschaffen, A -- Gilliland, M A -- Bergmann, B M -- Winter, J B -- MH-18428/MH/NIMH NIH HHS/ -- MH-4151/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857280" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenal Glands/pathology ; Animals ; Body Weight ; Electroencephalography ; Male ; Organ Size ; Rats ; Rats, Inbred Strains ; Sleep Deprivation/*physiology ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 89
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    Induction of hemoglobin accumulation in human K562 cells by hemin is reversible (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-24
    Beschreibung: Twenty micromolar hemin causes no change in the rate of division of K562 cells but results in accumulation of 11 to 14 picograms of embryonic and fetal hemoglobins per cell. This effect is reversible, and hemoglobin induction in response to hemin, and loss of hemoglobin upon removal of hemin, can be cyclically repeated. The cells can be indefinitely subcultured in the presence of the inducer. Thus, the control of hemoglobin levels in K562 cells does not depend on irreversible differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dean, A -- Erard, F -- Schneider, A P -- Schechter, A N -- AM 00103/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163216" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Differentiation/drug effects ; Cell Line ; Fetal Hemoglobin/biosynthesis ; Gene Expression Regulation/drug effects ; Heme/*analogs & derivatives ; Hemin/*pharmacology ; Hemoglobins/*biosynthesis ; Humans
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 90
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    Trauma-induced protein in rat tissues: a physiological role for a "heat shock" protein? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-02
    Beschreibung: Hyperthermic shock induces the synthesis of a novel protein (P71) in many rat tissues in vivo. In incubated rat tissue slices P71 is the major protein synthesized even though it is undetectable in the tissues of a normal, unstressed rat. P71 is "heat shock" protein, and it may be induced in vivo by stimuli other than hyperthermia. These results indicate that caution must be used in studies of protein synthesis in tissue explants, since the pattern of proteins synthesized by rat tissue slices is characteristic of stressed tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, R W -- White, F P -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):72-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280681" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Heat-Shock Proteins ; *Hot Temperature ; Isoelectric Point ; Male ; Molecular Weight ; Myocardium/metabolism ; *Protein Biosynthesis ; Rats ; Rats, Inbred Strains ; Stress, Physiological/*metabolism ; Tissue Distribution
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 91
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    Warburg effect revisited: merger of biochemistry and molecular biology (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Racker, E -- Spector, M -- CA-08964/CA/NCI NIH HHS/ -- CA-14454/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):303-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264596" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphatases/*metabolism ; Animals ; Avian Sarcoma Viruses/metabolism ; Brain/*enzymology ; Carcinoma, Ehrlich Tumor/*metabolism ; Cell Line ; Cell Transformation, Neoplastic ; Electric Organ/enzymology ; Electrophorus ; *Glycolysis/drug effects ; Macromolecular Substances ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Ouabain/pharmacology ; Oxidation-Reduction ; Polyomavirus/metabolism ; Protein Kinases/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 92
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    Intestinal diffusion barrier: unstirred water layer or membrane surface mucous coat? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: The dimensions of the small intestinal diffusion barrier interposed between luminal nutrients and their membrane receptors were determined from kinetic analysis of substrate hydrolysis by integral surface membrane enzymes. The calculated equivalent thickness of the unstirred water layer was too large to be compatible with the known dimensions of rat intestine. The discrepancy could be reconciled by consideration of the mucous coat overlying the intestinal surface membrane. Integral surface membrane proteins could not be labeled by an iodine-125 probe unless the surface coat was first removed. The mucoprotein surface coat appears to constitute an important diffusion barrier for nutrients seeking their digestive and transport sites on the outer intestinal membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smithson, K W -- Millar, D B -- Jacobs, L R -- Gray, G M -- AM 05418/AM/NIADDK NIH HHS/ -- AM 11270/AM/NIADDK NIH HHS/ -- AM 15802/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1241-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302593" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Membrane/*metabolism ; Diffusion ; Disaccharides/metabolism ; *Intestinal Absorption ; Jejunum/*metabolism/ultrastructure ; Kinetics ; Male ; Microscopy, Electron ; Microvilli/*metabolism/ultrastructure ; Rats ; Rats, Inbred Strains
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 93
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    Regulation of the macrophage content of neoplasms by chemoattractants (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 mouse tumors there was a correlation observed between chemotactic activity and macrophage content of neoplastic tissues. Tumor-derived chemoattractants appear to participate in the regulation of tumor-associated macrophages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bottazzi, B -- Polentarutti, N -- Acero, R -- Balsari, A -- Boraschi, D -- Ghezzi, P -- Salmona, M -- Mantovani, A -- R01 CA 12764/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):210-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828888" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Chemotactic Factors/*physiology ; Humans ; Leukemia/immunology ; Lymphoma/immunology ; Macrophages/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Transplantation ; Neoplasms/*immunology/physiopathology ; Neoplasms, Experimental/immunology ; Sarcoma/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 94
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    Lymphoid cell-glioma cell interaction enhances cell coat production by human gliomas: novel suppressor mechanism (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-13
    Beschreibung: Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat production is substantially enhanced by the interaction of glioma cells with a macromolecular factor released by human peripheral blood mononuclear cells in culture. This interaction thus constitutes an unusual mechanism by which inflammatory cells may nonspecifically suppress the cellular immune response to at least one class of solid tumors in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dick, S J -- Macchi, B -- Papazoglou, S -- Oldfield, E H -- Kornblith, P L -- Smith, B H -- Gately, M K -- New York, N.Y. -- Science. 1983 May 13;220(4598):739-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6220469" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cytotoxicity, Immunologic ; Glioma/immunology/*metabolism ; Glycosaminoglycans/biosynthesis ; Humans ; Hyaluronoglucosaminidase/metabolism ; Immunity, Cellular ; Lymphocytes/immunology/*metabolism ; Mice ; Rabbits
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 95
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    Mutation affecting the 12th amino acid of the c-Ha-ras oncogene product occurs infrequently in human cancer (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: A point mutation alters the 12th amino acid of the c-Ha-ras oncogene product p21 in a human bladder cancer cell line. This is, at present, the only mutation known to result in a human transforming gene. This mutation may therefore represent a possible target for mutagenesis leading to carcinogenesis in humans. By means of restriction enzyme analysis, 29 human cancers, including 20 primary tumor tissues, derived from organs commonly exposed to environmental carcinogens, were tested for the presence of this mutation. None of ten primary bladder carcinomas exhibited the mutation; nor did nine colon carcinomas or ten carcinomas of the lung. Thus the point mutation affecting the 12th amino acid of the c-Ha-ras gene product, while a valuable model for carcinogenesis, does not appear to play a role in the development of most human epithelial cancers of the bladder, colon, or lung.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feinberg, A P -- Vogelstein, B -- Droller, M J -- Baylin, S B -- Nelkin, B D -- 09071/PHS HHS/ -- 24592/PHS HHS/ -- 31053/PHS HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304875" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/genetics ; Carcinoma, Small Cell/genetics ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Transitional Cell/genetics ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Colonic Neoplasms/genetics ; Humans ; Lung Neoplasms/genetics ; *Mutation ; Neoplasm Proteins/*genetics ; *Oncogenes ; Proto-Oncogene Proteins p21(ras) ; Urinary Bladder Neoplasms/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 96
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    Insulin elicits ingestion in decerebrate rats (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-08
    Beschreibung: Insulin administered to rats reliably elicits ingestion of food. To determine whether the neural mechanisms sufficient to control insulin-elicited ingestion are located in or caudal to the forebrain, decerebrate rats were treated with insulin and ingestive responses were measured. Insulin treatment produced hypoglycemia that was comparable, in magnitude and duration, in control and decerebrate rats. Decerebrate and control rats ingested significantly more sucrose solution while hypoglycemic than while normoglycemic. In contrast, insulin did not augment the water consumption of either group. These data indicate that neural systems caudal to the forebrain are sufficient to control ingestive consummatory behavior through the integration of metabolic signals generated by insulin treatment and taste afferent input from the oropharynx.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flynn, F W -- Grill, H J -- AM 21397/AM/NIADDK NIH HHS/ -- T32-MH15012/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344221" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blood Glucose/analysis ; Brain/*physiology ; Decerebrate State/physiopathology ; Eating/*drug effects ; Energy Metabolism ; Insulin/*pharmacology ; Male ; Rats ; Rats, Inbred Strains ; Taste/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 97
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    Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-04
    Beschreibung: The human cellular homolog of the transforming DNA sequence isolated from the bladder carcinoma cell line EJ was localized on the short arm of human chromosome 11 by Southern blot analysis of human-rodent hybrid cell DNA. This locus contains human sequences homologous to the Harvey murine sarcoma virus v-Ha-ras oncogene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Martinville, B -- Giacalone, J -- Shih, C -- Weinberg, R A -- Francke, U -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297001" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Chromosome Mapping ; *Chromosomes, Human, 6-12 and X ; DNA Restriction Enzymes ; Humans ; Hybrid Cells ; Nucleic Acid Hybridization ; *Oncogenes ; Urinary Bladder Neoplasms/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 98
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    Tumor promotion by phorbol esters in skin: evidence for a memory effect (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-01
    Beschreibung: By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12-O-tetradecanoylphorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furstenberger, G -- Sorg, B -- Marks, F -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828884" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carcinogens/*pharmacology ; Cell Line ; Epidermis/drug effects ; Female ; Hyperplasia/chemically induced ; Mice ; Mice, Inbred Strains ; Neoplasms, Experimental/chemically induced ; Phorbol Esters/*adverse effects ; Phorbols/*adverse effects ; Precancerous Conditions/chemically induced ; Skin Neoplasms/*chemically induced ; Tetradecanoylphorbol Acetate/*adverse effects ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 99
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    Serum factor supporting long-term survival of rat central neurons in culture (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: Gel filtration of serum at pH 3.6 yielded a fraction that supported long-term (months) survival of dissociated rat central neurons in monolayer culture more reliably than the traditionally used unfractionated serum. The cultures remained neuron-rich, because this fraction did not support the proliferation of glia and fibroblasts that occurs in whole serum. With an apparent molecular weight of 55,000 and an isoelectric point of 5.6, the active factor (or factors) in this fraction is distinct from any well-defined growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaufman, L M -- Barrett, J N -- NS07044/NS/NINDS NIH HHS/ -- NS12207/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1394-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857258" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cattle ; *Cell Survival/drug effects ; Cells, Cultured ; Chromatography, Gel ; Horses ; Isoelectric Focusing ; Molecular Weight ; Nerve Growth Factors/isolation & purification/*pharmacology ; Neurons/drug effects/*physiology ; Rats ; Rats, Inbred Strains ; Spinal Cord/cytology
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 100
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    Clerics urge ban on altering germline cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1360-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6574603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Advisory Committees ; Cell Line ; *Ethics, Medical ; Federal Government ; Genetic Diseases, Inborn/therapy ; *Genetic Engineering ; *Germ Cells ; *Government Regulation ; Human Characteristics ; Humans ; Risk Assessment ; United States ; cells has been signed by leaders of almost every major church group in the United ; States. Some of the religious leaders, while not certain that a total moratorium ; should be placed on altering germline cells, signed the statement in order to ; stimulate public debate on the issue. Legislation has recently been introduced in ; Congress to set up a committee to monitor genetic engineering and its human ; applications, but author Jeremy Rifkin, the impetus behind the church leaders' ; resolution, argues that such tampering threatens the gene pool and should be ; banned altogether.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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