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  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-07-20
    Beschreibung: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-20
    Beschreibung: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-10-19
    Beschreibung: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-31
    Beschreibung: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-10-19
    Beschreibung: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-31
    Beschreibung: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-05-11
    Beschreibung: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-16
    Beschreibung: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-16
    Beschreibung: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-16
    Beschreibung: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-15
    Beschreibung: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-02
    Beschreibung: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-09
    Beschreibung: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-08
    Beschreibung: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-16
    Beschreibung: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-05-15
    Beschreibung: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-11
    Beschreibung: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 23
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-01-30
    Beschreibung: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 24
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-03-13
    Beschreibung: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 26
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 28
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-05-25
    Beschreibung: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 29
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    Onboard computer for Orbiting Astronomical Observatory mission (1970)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-27
    Beschreibung: General purpose computer for onboard processing of data for OAO missions
    Schlagwort(e): COMPUTERS
    Materialart: OPT. TELESCOPE TECHNOL. 1970; P 693-697
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    NASA TECHNICAL REPORTS
  • 30
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    Space sciences data-handling and mission operations (1970)
    In:  CASI
    Details
    Publikationsdatum: 2005-11-27
    Beschreibung: Real-time ground processing of space mission telemetry data from orbiting telescopes
    Schlagwort(e): COMPUTERS
    Materialart: OPT. TELESCOPE TECHNOL. 1970; P 103-112
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    NASA TECHNICAL REPORTS
  • 31
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    Automated tracking data analysis (1970)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-25
    Beschreibung: Computer controlled automatic tracking data analysis with graphic display
    Schlagwort(e): COMPUTERS
    Materialart: NIFICANT ACCOMPLISHMENTS IN SCI. AND TECHNOL. AT GODDARD SPACE FLIGHT CENTER 1970; P 331-336
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    NASA TECHNICAL REPORTS
  • 32
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    Development of a small computer for on board processing (1970)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-25
    Beschreibung: Stored program computer for onboard spacecraft data processing
    Schlagwort(e): COMPUTERS
    Materialart: NIFICANT ACCOMPLISHMENTS IN SCI. AND TECHNOL. AT GODDARD SPACE FLIGHT CENTER 1970; P 289-291
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    NASA TECHNICAL REPORTS
  • 33
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    Status of basic data reduction and processing (1970)
    In:  Other Sources
    Details
    Publikationsdatum: 2011-08-16
    Beschreibung: BOMEX data reduction and processing status, including rawinsonde data and radiation analysis
    Schlagwort(e): COMPUTERS
    Materialart: BOMEX BULL., NO. 8 OCT. 1970; P 37-40
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  • 34
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    A heuristic optimization algorithm for arranging an N page open string (1970)
    In:  Other Sources
    Details
    Publikationsdatum: 2011-08-16
    Beschreibung: Heuristic optimization algorithm for arranging N page open string
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 35
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    Resource allocation and the avoidance of deadlocks (1970)
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    Publikationsdatum: 2011-08-16
    Beschreibung: Resource allocation and avoidance of deadlocks in application of cellular array logic to LSI
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 36
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    A classification and survey of computer system performance evaluation techniques (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Classification and survey of computer system performance evaluation techniques
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 37
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    Fast multiplication cellular arrays for LSI implementation (1970)
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    Publikationsdatum: 2011-08-16
    Beschreibung: Fast multiplication cellular arrays for LSI implementation
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 38
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    The equivalence of rank permutation codes to a new class of binary codes (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Rank permutation codes equivalence to binary code class capable of generation and detection through direct and inverse transformations respectively
    Schlagwort(e): COMPUTERS
    Materialart: ; ACE(
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  • 39
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    Digital filtering of random digits (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Digital simulation of linear filter, investigating noise and rounding errors effects on decoding signals from lunar and interplanetary probes
    Schlagwort(e): COMPUTERS
    Materialart: ; 37 (
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  • 40
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    Simulation of the performance of computer systems (1970)
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    Publikationsdatum: 2011-08-16
    Beschreibung: Computer systems performance simulation, discussing data collection and preparation and language selection
    Schlagwort(e): COMPUTERS
    Materialart: ; YAL SOCIETY (
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  • 41
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    Status of data processing and reduction /15 June 1970/ (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Status summaries of BOMEX data processing and data reduction as of 15 June 1970
    Schlagwort(e): COMPUTERS
    Materialart: BOMEX BULL., NO. 7 JUL. 1970; P 25-34
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  • 42
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    A survey of resource allocation disciplines in multiprocessing systems (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Survey of resource allocation disciplines in multiprocessing systems with application of algorithms
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 43
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    The FORTRAN parallel task recognizer (1970)
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    Publikationsdatum: 2011-08-16
    Beschreibung: Design of FORTRAN parallel task recognizer program
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 44
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    On the symmetry of good nonlinear codes (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Existence theorem concerning arbitrarily long good binary block /nonlinear/ codes preserved under large permutation groups
    Schlagwort(e): COMPUTERS
    Materialart: ; ACE(
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  • 45
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    Unified hardware/software design (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Unified hardware/software design for computer systems optimization
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 46
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    Organizing a special purpose computer using the FFT to perform speech analysis in real time (1970)
    In:  Other Sources
    Details
    Publikationsdatum: 2011-08-16
    Beschreibung: Design of special purpose computer using FFT to perform speech analysis in real time
    Schlagwort(e): COMPUTERS
    Materialart: COMPUTER DESIGNING AND PROGRAMMING 16 MAY 1970 (SEE N71-13654 04-08)
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  • 47
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    Automatic processing of earth resource data (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Reviewing research on processing data from multispectral band scanners for agricultural applications
    Schlagwort(e): COMPUTERS
    Materialart: NASA. MANNED SPACECRAFT CENTER 2D ANN. EARTH RESOURCES AIRCRAFT PROGRAM STATUS REV., VOL. 2 1969 (SEE N71-11976 02-13)
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  • 48
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    Data subsystems for 12-year missions (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Thermoelectric outer planet spacecraft /TOPS/ data subsystems for 12 year missions compared with Mariner subsystem
    Schlagwort(e): COMPUTERS
    Materialart: ; ADEMIE DES SCIENCES
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  • 49
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    Reduction of machine time in discrete ordinates calculations (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Two dimensional Sn computer code for reactor kinetics calculations in data reduction
    Schlagwort(e): COMPUTERS
    Materialart: AM. NUCL. SOC. PROC. OF THE CONF. ON THE EFFECTIVE USE OF COMPUTERS IN THE NUCL. IND. 〈1969〈; P 234-246
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  • 50
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    Linear filtering and piecewise linear correlation functions. (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-12
    Beschreibung: Optimal linear mean square filtering for piecewise linear correlation functions
    Schlagwort(e): COMPUTERS
    Materialart: ; RNIER-POST (
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  • 51
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    Midcourse maneuver program (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-12
    Beschreibung: Midcourse maneuver program for Mariner 5 space probe
    Schlagwort(e): COMPUTERS
    Materialart: THE MARINER 5 FLIGHT PATH AND ITS DETERMINATION FROM TRACKING DATA 1 JUL. 1969; P 46-47
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  • 52
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    Computer (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Arithmetic and code-checking routines of ILLAR system and recursive subprogram in FORTRAN compiler
    Schlagwort(e): COMPUTERS
    Materialart: COORDINATED SCI. LAB. 1 AUG. 1969; P 185-193
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  • 53
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    Event priority instrumentation system for nuclear experiments on scientific satellites (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Instrumentation system for nuclear experiments on scientific satellites allowing highest priority event selection during telemetry sequence and periodic change of priority order
    Schlagwort(e): COMPUTERS
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  • 54
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    Onboard data management (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Configurations and functions of onboard data processing for space shuttles
    Schlagwort(e): COMPUTERS
    Materialart: NASA. LEWIS RES. CENTER SPACE TRANSPORTATION SYSTEM TECHNOL. SYMP., VOL. 6 JUL. 1970; P 85-90
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  • 55
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    Cognitive memory (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Perceptive cognition system structurally analyzed with semantic techniques for parsing and compiling
    Schlagwort(e): COMPUTERS
    Materialart: COORDINATED SCI. LAB. 1 AUG. 1969; P 296-336
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  • 56
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    Plasma display (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Development and production of rectangular display panel connected to digital computer for two on state operation
    Schlagwort(e): COMPUTERS
    Materialart: COORDINATED SCI. LAB. 1 AUG. 1969; P 194-225
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  • 57
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    COHORT-2 - A Monte Carlo general purpose shielding computer code (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: COHORT 2 Monte Carlo general purpose shielding computer code
    Schlagwort(e): COMPUTERS
    Materialart: AM. NUCL. SOC. PROC. OF THE CONF. ON THE EFFECTIVE USE OF COMPUTERS IN THE NUCL. IND. 〈1969〈; P 676-685
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  • 58
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    Central data system concepts for spacecraft data management. (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-12
    Beschreibung: Spacecraft central data system for deep space solar probe data management
    Schlagwort(e): COMPUTERS
    Materialart: ; STITUTION OF ENGINEE
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  • 59
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    On-board spacecraft processor. (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-12
    Beschreibung: Onboard processor servicing spacecraft sensors, programmable from ground, discussing functions and applications
    Schlagwort(e): COMPUTERS
    Materialart: ; RO(
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  • 60
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    Design using symbolic topological equations. (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-12
    Beschreibung: Network synthesis technique applied to structural dynamics design, using topological formulas to express systems response transfer functions
    Schlagwort(e): COMPUTERS
    Materialart: ; RNIER-POST (
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  • 61
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    Negative radix conversion (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Negative radix conversion results applied to logical design of serial converter
    Schlagwort(e): COMPUTERS
    Materialart: ; ADEMIE DES SCIENCES
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  • 62
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    Solution of linear inequalities (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Consistent and inconsistent linear inequalities evaluating speed and efficiency of algorithm for pattern recognition problems
    Schlagwort(e): COMPUTERS
    Materialart: ; ADEMIE DES SCIENCES
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  • 63
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    Modular computer research (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Onboard modular computer research in strapdown guidance technology for computational ability and long term reliability of unmanned missions
    Schlagwort(e): COMPUTERS
    Materialart: ; 459 (
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  • 64
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    Realization of optimum interleavers (1970)
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    Publikationsdatum: 2011-08-16
    Beschreibung: Optimum interleavers realization procedure for reordering contiguous symbols sequence to satisfy minimum distance requirement for improving communication system performance
    Schlagwort(e): COMPUTERS
    Materialart: ; YSICA STATUS SOLIDI
    Format: text
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  • 65
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    A real-time operating system for manned spaceflight (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Ground support real time operating system 360 for manned spaceflight, discussing system features and performance
    Schlagwort(e): COMPUTERS
    Materialart: ; SEARCH(
    Format: text
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  • 66
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    A programming system for analytical series expansions on a computer (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Programming system for Poisson series manipulation on computer, writing subroutines in machine language
    Schlagwort(e): COMPUTERS
    Materialart: ; ADEMIE DES SCIENCES
    Format: text
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  • 67
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    AUTOFLOW enhancements for documentation and maintenance of scientific applications (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: The use of the AUTOFLOW system is discussed in terms of improving automated documentation. Flowcharts produced by AUTOFLOW are considered to be much more meaningful than those produced manually in that they are accurate, present complete references between all transfer points, and graphically portray the logical flow by automatic rearrangement of those segments of the program that interact.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 9-31; NASA-TM-X-66196
    Format: application/pdf
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  • 68
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    MCC/GSFC/RS General Description (1970)
    In:  CASI
    Details
    Publikationsdatum: 2014-08-30
    Beschreibung: Apollo real time computer complex, remote site equipment, and communications, command, and telemetry system
    Schlagwort(e): COMPUTERS
    Materialart: APOLLO MCC(MSFN MISSION CONFIGURATION COMMAND COMMUN. TELEMETRY TRACKING MAR. 1970 P 113-164 )SEE N70-33564 18-07/; APOLLO MCC
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  • 69
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    Software integration for integrated electronics (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Minimizing cost and schedule problems of integrating software of avionics system
    Schlagwort(e): COMPUTERS
    Materialart: NASA. LEWIS RES. CENTER SPACE TRANSPORTATION SYSTEM TECHNOL. SYMP., VOL. 6 JUL. 1970; P 51-66
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  • 70
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    Computer generated imagery as applied to space shuttle design evaluation and system simulation (1970)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Computerized visual scene simulation for control and landing of space shuttle vehicles
    Schlagwort(e): COMPUTERS
    Materialart: NASA. LEWIS RES. CENTER SPACE TRANSPORTATION SYSTEM TECHNOL. SYMP., VOL. 6 JUL. 1970; P 313-322
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  • 71
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    Photochromic memory for computer applications (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-16
    Beschreibung: Potassium chloride crystal color centers as photochromic memory device in computer systems
    Schlagwort(e): COMPUTERS
    Materialart: COORDINATED SCI. LAB. 1 AUG. 1969; P 349-351
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  • 72
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    A digital computer for antenna pointing. (1969)
    In:  Other Sources
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    Publikationsdatum: 2011-08-12
    Beschreibung: Onboard digital computer evaluation of trigonometric functions for antenna pointing
    Schlagwort(e): COMPUTERS
    Materialart: ; UGREVUE(
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  • 73
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    Phenomenological approach to scatterometer data interpretation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2016-06-07
    Beschreibung: A graphic method of analyzing radar scatterometer sea clutter data leading to linear relations between scattering cross sections and tan angle of incidence of the radiation is proposed. This relation permits formulation of simple analytic relations without reference to the ocean surface spectrum. Parameters introduced depend on the wavelength of the incident radiation and its polarization, and on wind and sea states. The simplicity of the expressions derived suggests a corresponding simplicity in the physical mechanism of radar sea clutter return.
    Schlagwort(e): COMPUTERS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., Vol. 2; 8 p
    Format: application/pdf
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  • 74
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    User oriented data processing at the University of Michigan (1970)
    In:  CASI
    Details
    Publikationsdatum: 2016-06-07
    Beschreibung: The multispectral techniques have shown themselves capable of solving problems in a large number of user areas. The results obtained are in some instances quite impressive. In many instances, the multispectral detection of various phenomena is an empirical fact for which there is little physical explanation today. To date, most of the user applications that have been addressed are exploratory in nature. The closest approximation to an operational situation encountered so far is that of the survey of wetlands in North Dakota reported in this paper.
    Schlagwort(e): COMPUTERS
    Materialart: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., Vol. 2; 18 p
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  • 75
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    Applications of structural redundancy to increase the reliability of analogue-digital functional converters (1969)
    In:  Other Sources
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    Publikationsdatum: 2019-01-25
    Beschreibung: Structural redundancy for optimal reliability of analog to digital converters
    Schlagwort(e): COMPUTERS
    Materialart: AUTOM. CONTROL 1969; P 173-185
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  • 76
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    Determination of the statistical characteristics of disturbance in a sampled- data system during operation (1969)
    In:  Other Sources
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    Publikationsdatum: 2019-01-25
    Beschreibung: Discrete filter for determining autocorrelation functions of internal disturbances in sampled data control system during operation
    Schlagwort(e): COMPUTERS
    Materialart: AUTOM. CONTROL 1969; P 101-107
    Format: text
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  • 77
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    Tree-structured information file and its subprogram subtree (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: Development documentation programs are considered. A document tree is defined as the syntactic representation of a document when it is divided into subdivisions such as chapters and sections; a developmental tree is also defined as a tree of information obtained during the course of the development of the computer program. A developmental subtree is emphasized and described. A printed subprogram is also included.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 223-243; NASA-TM-X-66196
    Format: application/pdf
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  • 78
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    Automated documentation of an assembly program (1970)
    In:  CASI
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    Publikationsdatum: 2015-08-25
    Beschreibung: A program is discussed that can be used as input to another program which will automatically document it. This program was implemented using assembly language program, META-SYMBOL, on XDS 930 computer. The characteristics and identification of the documentation program, DOCMNT, are described.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 141-146; NASA-TM-X-66196
    Format: application/pdf
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  • 79
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    Making automated computer program documentation a feature of total system design (1970)
    In:  CASI
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    Publikationsdatum: 2015-08-25
    Beschreibung: It is pointed out that in large-scale computer software systems, program documents are too often fraught with errors, out of date, poorly written, and sometimes nonexistent in whole or in part. The means are described by which many of these typical system documentation problems were overcome in a large and dynamic software project. A systems approach was employed which encompassed such items as: (1) configuration management; (2) standards and conventions; (3) collection of program information into central data banks; (4) interaction among executive, compiler, central data banks, and configuration management; and (5) automatic documentation. A complete description of the overall system is given.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 87-104; NASA-TM-X-66196
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    An automated system for generating program documentation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: A documentation program was developed in which the emphasis is placed on text content rather than flowcharting. It is keyword oriented, with 26 keywords that control the program. Seventeen of those keywords are recognized by the flowchart generator, three are related to text generation, and three have to do with control card and deck displays. The strongest advantage offered by the documentation program is that it produces the entire document. The document is prepared on 35mm microfilm, which is easy to store, and letter-size reproductions can be made inexpensively on bond paper.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 43-60; NASA-TM-X-66196
    Format: application/pdf
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  • 81
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    The BELLFLOW system (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: The BELLFLOW flowcharting system was developed to meet certain Bell System standards of documentation. There are three modes of operation with the BELLFLOW system: source mode, comment mode, and mixed mode. In the source mode, all of the flowcharting information is derived directly from the source code. In the comment mode, BELLFLOW ignores the source code completely and derives the entire flowchart purely from comments imbedded in the program. In the mixed mode, the source and comment mode are combined. The mixed mode is unique to BELLFLOW and was designed to provide a self-documenting program source deck. Other features of BELLFLOW include: automatic placement, automatic line routing, paging, and generation of on and off sheet connectors.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 33-42; NASA-TM-X-66196
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  • 82
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    Program analysis for documentation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: A program analysis for documentation (PAD) written in FORTRAN has three steps: listing the variables, describing the structure and writing the program specifications. Technical notes on editing criteria for reviewing program documentation, technical notes for PAD, and FORTRAN program analyzer for documentation are appended.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 213-221; NASA-TM-X-66196
    Format: application/pdf
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  • 83
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    Cost advantages of an integrated documentation approach (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: Interactive use of on-line computing terminals for updating programs is discussed. An integrated documentation approach using predocumented subroutines and metaprogram techniques is found to be an efficient means of generating the relevant documentation and of reducing program development costs.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 157-166; NASA-TM-X-66196
    Format: application/pdf
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  • 84
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    Automatic editing of manuals (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: The documentation problem is discussed that arises in getting all the many items included in a computer program prepared in a timely fashion and keeping them all correct and mutually consistent during the life of the program. The proposed approach to the problem is to collect all the necessary information into a single document, which is maintained with computer assistance during the life of the program and from which the required subdocuments can be extracted as desired. Implementation of this approach requires a package of programs for computer editorial assistance and is facilitated by certain programming practices that are discussed.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 81-85; NASA-TM-X-66196
    Format: application/pdf
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  • 85
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    Unbekannt
    Program automated documentation methods (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: The mission analysis and trajectory simulation program is summarized; it provides an understanding of the size and complexity of one simulation for which documentation is mandatory. Programs for automating documentation of subroutines, flow charts, and internal cross reference information are also included.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 187-205; NASA-TM-X-66196
    Format: application/pdf
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  • 86
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    Autodocumentation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: Automated documentation systems with expanded capabilities for reusing existing programs are considered by allowing a relatively inexpensive determination of program capabilities. A theoretical approach to such a system is proposed. Tree structure variations are examined, along with assignment statements, conditional branches, loops, and an automated analyzer.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 147-155; NASA-TM-X-66196
    Format: application/pdf
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  • 87
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    Syntax-directed documentation for PL360 (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: PL360 is a phrase-structured programming language which provides the facilities of a symbolic machine language for the IBM 360 computers. An automatic process, syntax-directed documentation, is described which acquires programming documentation through the syntactical analysis of a program, followed by the interrogation of the originating programmer. This documentation can be dispensed through reports of file query replies when other programmers later need to know the program structure and its details. A key principle of the programming documentation process is that it is managed solely on the basis of the syntax of programs.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 105-116; NASA-TM-X-66196
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  • 88
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    Views on computer program documentation and automation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: Various aspects of the problem of program documentation and description are discussed. Particular emphasis is placed on the problem of semantics. It is pointed out that the information produced by documentation of a program, if presented to several different groups, may mean entirely different things to these groups. Recognition of the fact that people look at problems differently is proposed as a more practical approach to the problem of documentation rather than extensive use of standards or strict formatting. The difficulties involved in searching for ways to provide a common ground for the transmission and use of information are discussed.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 77-79; NASA-TM-X-66196
    Format: application/pdf
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  • 89
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    Program documentation with advanced data management systems (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: The problems of program documentation are considered for those cases in which the programmer is using a computer along with an advanced DMS. Three problem areas discussed include: data description, process description, and execution-time documentation.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 3-7; NASA-TM-X-66196
    Format: application/pdf
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  • 90
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    A scan processor as an aid to program documentation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: Program documentation was separated into two catagories: documentation for program use and documentation for program analysis, modification, or extension. The symbol scanner, flow chart production subsystem, decision table subsystem, and scan processor are also described.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 245-255; NASA-TM-X-66196
    Format: application/pdf
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  • 91
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    Automated Engineering Design (AED); An approach to automated documentation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: The automated engineering design (AED) is reviewed, consisting of a high level systems programming language, a series of modular precoded subroutines, and a set of powerful software machine tools that effectively automate the production and design of new languages. AED is used primarily for development of problem and user-oriented languages. Software production phases are diagramed, and factors which inhibit effective documentation are evaluated.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 207-212; NASA-TM-X-66196
    Format: application/pdf
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  • 92
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    Automatic program annotation (AUTONOTE) (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: A preliminary identification of tools that can be used in the documentation process is described. Some areas of program documentation are identified for automation. The assembly language program is emphasized.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 167-184; NASA-TM-X-66196
    Format: application/pdf
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  • 93
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    COSMIC program documentation experience (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: A brief history of COSMIC as it relates to the handling of program documentation is summarized; the items that are essential for computer program documentation are also discussed. COSMIC documentation and program standards handbook is appended.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 131-139; NASA-TM-X-66196
    Format: application/pdf
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  • 94
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    Documentation: Motivation and training or automation (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: The road blocks and mental blocks in areas where automation is not taking care of basic documentation problems are discussed. Original project documentation, documentation for project maintenance, and comparison of preliminary and final documentation are described. The use of flow charts is also mentioned.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 117-127; NASA-TM-X-66196
    Format: application/pdf
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  • 95
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    The integration of system specifications and program coding (1970)
    In:  CASI
    Details
    Publikationsdatum: 2015-08-25
    Beschreibung: Experience in maintaining up-to-date documentation for one module of the large-scale Medical Literature Analysis and Retrieval System 2 (MEDLARS 2) is described. Several innovative techniques were explored in the development of this system's data management environment, particularly those that use PL/I as an automatic documenter. The PL/I data description section can provide automatic documentation by means of a master description of data elements that has long and highly meaningful mnemonic names and a formalized technique for the production of descriptive commentary. The techniques discussed are practical methods that employ the computer during system development in a manner that assists system implementation, provides interim documentation for customer review, and satisfies some of the deliverable documentation requirements.
    Schlagwort(e): COMPUTERS
    Materialart: Automated Methods of Computer Program Doc.; p 61-74; NASA-TM-X-66196
    Format: application/pdf
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  • 96
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    Error correcting in asynchronous automata (1969)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-01-25
    Beschreibung: Error correcting codes for improved reliability of logical automata
    Schlagwort(e): COMPUTERS
    Materialart: AUTOM. CONTROL 1969; P 63-71
    Format: text
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  • 97
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    Determining the initial and compatible internal states of the inverse automaton of Class 2 by analyzing the operation of the original automaton (1969)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-01-25
    Beschreibung: Determining compatible internal states of inverse automation by analysis of original automation
    Schlagwort(e): COMPUTERS
    Materialart: AUTOM. CONTROL 1969; P 26-31
    Format: text
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  • 98
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    Synthesis of sequential asynchronous logical automata using three types of modules (1969)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-01-25
    Beschreibung: Synthesis of sequential logical automata with three types of modules
    Schlagwort(e): COMPUTERS
    Materialart: AUTOM. CONTROL 1969; P 16-25
    Format: text
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  • 99
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    Flight operations and DSN programming (1970)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-01-25
    Beschreibung: Computer programs for calculating trajectories to Mars and Jupiter
    Schlagwort(e): COMPUTERS
    Materialart: SPACE PROGRAMS SUM. NO. 37-65, VOL. 3, AUG. - SEP. 1970 31 OCT. 1970; P 12-15
    Format: text
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  • 100
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    Design of a two-cycle shift ferrite-diode register with allowance for component tolerances (1969)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-01-25
    Beschreibung: Design of two-cycle shift register using magnetic and electric parameters of ferrite-diode components
    Schlagwort(e): COMPUTERS
    Materialart: AUTOM. CONTROL 1969; P 210-219
    Format: text
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