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  • 1
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    Influence of protozoan grazing on the marine geochemistry of particle reactive trace metals (2012)
    Massachusetts Institute of Technology and Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-25
    Description: Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution May 1998
    Description: Planktonic protozoan grazers have the potential to significantly affect the chemistry of particle-associated trace metals. This is due both to the importance of protists as consumers of bacterial-sized particles, and to the unique low-pH, enzyme-rich microenvironment of the grazer food vacuole. This thesis examines the role of protozoan grazers in the marine geochemistry of strongly hydrolyzed, particle-reactive trace metals, in particular Th and Fe. A series of tracer experiments was carried out in model systems in order to determine the effect of grazer-mediated transformations on the chemical speciation and partitioning of radioisotopes C9Fe, 234Th, 51Cr) associated with prey cells. Results indicate that protozoan grazers are equally able to mobilize intracellular and extracellular trace metals. In some cases, protozoan regeneration of trace metals appears to lead to the formation of metal-organic complexes. Protozoan grazing may generate colloidal material that can scavenge trace metals and, via aggregation, lead to an increase in the metal/organic carbon ratio of aggregated particles. Model system experiments were also conducted in order to determine the effect of grazers on mineral phases, specifically colloidal iron oxide (ferrihydrite). Several independent techniques were employed, including size fractionation ors9Fe-labeled colloids, competitive ligand exchange, and iron-limited diatoms as "probes" for bioavailable Fe. Experimental evidence strongly suggests that protozoan grazing can affect the surface chemistry and increase the dissolution rate of iron oxide phases through phagotrophic ingestion. In further work on protozoan-mediated dissolution of colloidal Fe oxides, a novel tracer technique was developed based on the synthesis of colloidal ferrihydrite impregnated with 133Ba as an inert tracer. This technique was shown to be a sensitive, quantitative indicator for the extent of ferrihydrite dissolution/alteration by a variety of mechanisms, including photochemical reduction and ligand-mediated dissolution. In field experiments using this technique, grazing by naturally occuring protistan assemblages was shown to significantly enhance the dissolution rate of colloidal ferrihydrite over that in non-grazing controls. Laboratory and field results indicate that, when integrated temporally over the entire euphotic zone, protozoan grazing may equal or exceed photoreduction as a pathway for the dissolution of iron oxides.
    Description: This work was financially supported by a Department of Defense ONR-NDSEG Graduate Fellowship, Office ofNaval Research AASERT Award (N00014-94-1-0711), and the National Science Foundation EGB Program (OCE-9523910).
    Keywords: Protozoa ; Water chemistry ; Trace elements in water ; Marine zooplankton ; Chemistry
    Repository Name: Woods Hole Open Access Server
    Type: Thesis
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  • 2
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    U.S. budget. Science spared brunt of ax in budget request (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2012 Feb 17;335(6070):783-4. doi: 10.1126/science.335.6070.783.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22344417" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; National Institutes of Health (U.S.)/economics ; *Research Support as Topic/economics ; United States ; United States Government Agencies/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Conservation. Citizen involvement in the U.S. Endangered Species Act (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brosi, Berry J -- Biber, Eric G N -- New York, N.Y. -- Science. 2012 Aug 17;337(6096):802-3. doi: 10.1126/science.1220660.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Studies, Emory University, Atlanta, GA 30322, USA. bbrosi@emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22903999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Databases, Factual ; Endangered Species/*legislation & jurisprudence/*statistics & numerical data ; Population ; Regression Analysis ; Turtles ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Invasive species. Researchers set course to blockade ballast invaders (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strain, Daniel -- New York, N.Y. -- Science. 2012 May 11;336(6082):664-5. doi: 10.1126/science.336.6082.664.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22582239" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecosystem ; *Introduced Species ; *Lakes ; *Seawater ; *Ships ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Science and society. Social media and the elections (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Metaxas, Panagiotis T -- Mustafaraj, Eni -- New York, N.Y. -- Science. 2012 Oct 26;338(6106):472-3. doi: 10.1126/science.1230456.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Science, Wellesley College, 106 Central Street, Wellesley, MA 02481, USA. pmetaxas@wellesley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23112315" target="_blank"〉PubMed〈/a〉
    Keywords: *Decision Making ; *Politics ; *Social Media ; *Social Perception ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Retrospective. Paul Mead Doty (1920-2011) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meselson, Matthew -- New York, N.Y. -- Science. 2012 Jan 13;335(6065):181. doi: 10.1126/science.1218031.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. msm@wjh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22246766" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry/history ; DNA/chemistry ; History, 20th Century ; History, 21st Century ; Internationality ; Molecular Biology/history ; Nucleic Acid Conformation ; Nucleic Acid Renaturation ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Elfn1 regulates target-specific release probability at CA1-interneuron synapses (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: Although synaptic transmission may be unidirectional, the establishment of synaptic connections with specific properties can involve bidirectional signaling. Pyramidal neurons in the hippocampus form functionally distinct synapses onto two types of interneurons. Excitatory synapses onto oriens-lacunosum moleculare (O-LM) interneurons are facilitating and have a low release probability, whereas synapses onto parvalbumin interneurons are depressing and have a high release probability. Here, we show that the extracellular leucine-rich repeat fibronectin containing 1 (Elfn1) protein is selectively expressed by O-LM interneurons and regulates presynaptic release probability to direct the formation of highly facilitating pyramidal-O-LM synapses. Thus, postsynaptic expression of Elfn1 in O-LM interneurons regulates presynaptic release probability, which confers target-specific synaptic properties to pyramidal cell axons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sylwestrak, Emily L -- Ghosh, Anirvan -- R01 NS067216/NS/NINDS NIH HHS/ -- R01NS067216/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Oct 26;338(6106):536-40. doi: 10.1126/science.1222482. Epub 2012 Oct 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0366, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042292" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/metabolism ; CA1 Region, Hippocampal/*metabolism ; Cells, Cultured ; Gene Knockdown Techniques ; Green Fluorescent Proteins/genetics/metabolism ; HEK293 Cells ; Humans ; Interneurons/*metabolism ; Mice ; Nerve Tissue Proteins/genetics/*metabolism ; RNA, Small Interfering/metabolism ; Rats ; Rats, Inbred LEC ; Synapses/genetics/*metabolism ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    An end to waste? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hering, Janet G -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):623. doi: 10.1126/science.1227092.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879468" target="_blank"〉PubMed〈/a〉
    Keywords: Environment ; European Union ; Politics ; Recycling ; United States ; *Waste Management/legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    U.S. elections. Scientists urge Obama, Romney to address key S&T issues (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, Earl -- Ham, Becky -- New York, N.Y. -- Science. 2012 Aug 31;337(6098):1059.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22946130" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; Science/*trends ; Societies ; Technology/*trends ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Science policy. The payoff of federal R&D: iPod, Google, and Human Genome Project (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, Earl -- Ham, Becky -- New York, N.Y. -- Science. 2012 Apr 27;336(6080):433.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22548216" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Financing, Government ; Human Genome Project ; MP3-Player ; *Research Support as Topic ; Search Engine ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    A single progenitor population switches behavior to maintain and repair esophageal epithelium (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-24
    Description: Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, but the rate of cell division increases. However, after wounding, cells reversibly switch to producing an excess of proliferating daughters until the wound has closed. Such fate-switching enables a single progenitor population to both maintain and repair tissue without the need for a "reserve" slow-cycling stem cell pool.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527005/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527005/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doupe, David P -- Alcolea, Maria P -- Roshan, Amit -- Zhang, Gen -- Klein, Allon M -- Simons, Benjamin D -- Jones, Philip H -- 079249/Wellcome Trust/United Kingdom -- 092096/Wellcome Trust/United Kingdom -- G0601740/Medical Research Council/United Kingdom -- G0700600/1/National Centre for the Replacement, Refinement and Reduction of Animals in Research/United Kingdom -- G0800784/Medical Research Council/United Kingdom -- MC_U105370181/Medical Research Council/United Kingdom -- U.1053.00.010(70181)/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Aug 31;337(6098):1091-3. doi: 10.1126/science.1218835. Epub 2012 Jul 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council (MRC) Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22821983" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomarkers/analysis ; Cell Differentiation/drug effects ; Cell Division/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Doxycycline/pharmacology ; Epithelial Cells/*physiology ; Epithelium/drug effects/metabolism/*physiology ; Esophagus/*cytology/*physiology ; Green Fluorescent Proteins/biosynthesis ; Histones/biosynthesis ; Mice ; Mice, Inbred C57BL ; Recombinant Fusion Proteins/biosynthesis ; *Regeneration ; Stem Cells/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Retrospective. James F. Crow (1916-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dove, William -- Susman, Millard -- New York, N.Y. -- Science. 2012 Feb 17;335(6070):812. doi: 10.1126/science.1219557.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA. dove@oncology.wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22344436" target="_blank"〉PubMed〈/a〉
    Keywords: Genetics, Medical/*history ; Genetics, Population/*history ; History, 20th Century ; History, 21st Century ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-28
    Description: Mucus clearance is the primary defense mechanism that protects airways from inhaled infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel is propelled on top of a "watery" periciliary layer surrounding the cilia. However, this model fails to explain the formation of a distinct mucus layer in health or why mucus clearance fails in disease. We propose a gel-on-brush model in which the periciliary layer is occupied by membrane-spanning mucins and mucopolysaccharides densely tethered to the airway surface. This brush prevents mucus penetration into the periciliary space and causes mucus to form a distinct layer. The relative osmotic moduli of the mucus and periciliary brush layers explain both the stability of mucus clearance in health and its failure in airway disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633213/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633213/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Button, Brian -- Cai, Li-Heng -- Ehre, Camille -- Kesimer, Mehmet -- Hill, David B -- Sheehan, John K -- Boucher, Richard C -- Rubinstein, Michael -- HHSN268200900020/PHS HHS/ -- K01DK080847/DK/NIDDK NIH HHS/ -- P01HL108808/HL/NHLBI NIH HHS/ -- P01HL110873-01/HL/NHLBI NIH HHS/ -- P01HL34322/HL/NHLBI NIH HHS/ -- P30DK065988/DK/NIDDK NIH HHS/ -- P50HL107168/HL/NHLBI NIH HHS/ -- P50HL107168-01/HL/NHLBI NIH HHS/ -- R01 HL103940/HL/NHLBI NIH HHS/ -- R01HL077546/HL/NHLBI NIH HHS/ -- R01HL103940/HL/NHLBI NIH HHS/ -- UL1-RR025747/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 24;337(6097):937-41. doi: 10.1126/science.1223012.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cystic Fibrosis Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599-7248, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22923574" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Cilia/*physiology/ultrastructure ; Gels ; Glycosaminoglycans/*physiology ; Humans ; Lung/*physiology ; Lung Diseases/physiopathology ; *Models, Biological ; Mucins/*physiology ; *Mucociliary Clearance ; Mucus/*physiology ; Osmotic Pressure ; Respiratory Mucosa/*physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Nuclear safety. A safer nuclear enterprise (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drell, Sidney D -- Shultz, George P -- Andreasen, Steven P -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1236. doi: 10.1126/science.1221842.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford University, Stanford, CA 94305, USA. drell@slac.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22679084" target="_blank"〉PubMed〈/a〉
    Keywords: *Nuclear Energy ; *Nuclear Reactors ; *Nuclear Weapons ; Peer Review ; Radioactive Hazard Release/*prevention & control ; *Safety ; *Safety Management ; Security Measures ; Terrorism ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Research ethics. Aligning regulations and ethics in human research (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-04
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612933/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612933/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dresser, Rebecca -- UL1 RR024992/RR/NCRR NIH HHS/ -- UL1 TR000448/TR/NCATS NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 3;337(6094):527-8. doi: 10.1126/science.1218323.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Law, Washington University, St. Louis, MO 63130, USA. dresser@wulaw.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22859472" target="_blank"〉PubMed〈/a〉
    Keywords: Consent Forms/*standards ; *Guidelines as Topic ; Human Experimentation/*ethics/*statistics & numerical data ; Humans ; Informed Consent/*ethics/*standards ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Enabling scientific innovation (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Langer, James S -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):171. doi: 10.1126/science.1230947.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066044" target="_blank"〉PubMed〈/a〉
    Keywords: Developmental Biology/*economics ; Foundations ; *Peer Review, Research ; Physics/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Atmospheric science. From acid rain to climate change (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reis, S -- Grennfelt, P -- Klimont, Z -- Amann, M -- ApSimon, H -- Hettelingh, J-P -- Holland, M -- LeGall, A-C -- Maas, R -- Posch, M -- Spranger, T -- Sutton, M A -- Williams, M -- New York, N.Y. -- Science. 2012 Nov 30;338(6111):1153-4. doi: 10.1126/science.1226514.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Ecology & Hydrology, Penicuik EH26 0QB, UK. srei@ceh.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23197517" target="_blank"〉PubMed〈/a〉
    Keywords: Acid Rain/*prevention & control ; *Air Pollutants ; Air Pollution/*prevention & control ; Canada ; *Climate Change ; Environmental Policy/*trends ; Europe ; *Guidelines as Topic ; *United Nations ; United States ; Vehicle Emissions/prevention & control
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Education. Can a new vision bring new life to biology class? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2012 Aug 31;337(6098):1058-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22946129" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/*education ; Biomedical Research/*education/*trends ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Science and law. When scientific research and legal practice collide (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Camilli, R -- Bowen, A -- Reddy, C M -- Seewald, J S -- Yoerger, D R -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1608-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Applied Ocean Physics and Engineering Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. rcamilli@whoi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019634" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects ; 2,4-Dichlorophenoxyacetic Acid/adverse effects ; Chemical Industry/*legislation & jurisprudence ; Disasters/prevention & control ; Drug Industry/*legislation & jurisprudence ; Expert Testimony/legislation & jurisprudence ; Research/*legislation & jurisprudence ; Tetrachlorodibenzodioxin/adverse effects ; United States ; United States Environmental Protection Agency/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Profile: Kit Parker. Engineering a new line of attack on a signature war injury (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2012 Jan 6;335(6064):33-5. doi: 10.1126/science.335.6064.33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22223790" target="_blank"〉PubMed〈/a〉
    Keywords: Afghan Campaign 2001- ; Animals ; Axons/pathology ; Blast Injuries/pathology/*physiopathology ; Brain Injuries/epidemiology/pathology/*physiopathology ; Cells, Cultured ; History, 21st Century ; Humans ; Integrins/metabolism ; Iraq War, 2003-2011 ; Neurons/physiology ; Tissue Engineering ; Vasospasm, Intracranial/pathology/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: Mammalian imprinted genes often cluster with long noncoding (lnc) RNAs. Three lncRNAs that induce parental-specific silencing show hallmarks indicating that their transcription is more important than their product. To test whether Airn transcription or product silences the Igf2r gene, we shortened the endogenous lncRNA to different lengths. The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin. Such a repressor function for lncRNA transcriptional overlap reveals a gene silencing mechanism that may be widespread in the mammalian genome, given the abundance of lncRNA transcripts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Latos, Paulina A -- Pauler, Florian M -- Koerner, Martha V -- Senergin, H Basak -- Hudson, Quanah J -- Stocsits, Roman R -- Allhoff, Wolfgang -- Stricker, Stefan H -- Klement, Ruth M -- Warczok, Katarzyna E -- Aumayr, Karin -- Pasierbek, Pawel -- Barlow, Denise P -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1469-72. doi: 10.1126/science.1228110.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239737" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Cells, Cultured ; *Gene Silencing ; *Genomic Imprinting ; Mice ; Multigene Family ; Promoter Regions, Genetic ; RNA Polymerase II/metabolism ; RNA, Long Noncoding/genetics/*metabolism ; Receptor, IGF Type 2/*genetics ; *Transcription, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Climate change. The greening of insurance (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mills, Evan -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1424-5. doi: 10.1126/science.1229351.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. emills@lbl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239720" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Climate Change/*economics ; Humans ; Insurance/*trends ; Risk ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    IBI series winner. Solving complex problems (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hodges, K V -- New York, N.Y. -- Science. 2012 Nov 30;338(6111):1164-5. doi: 10.1126/science.1215228.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287, USA. kvhodges@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23197525" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; Education, Professional/*methods ; Engineering/*education ; Humans ; *Problem Solving ; Science/*education ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Asymmetric segregation of polarized antigen on B cell division shapes presentation capacity (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-28
    Description: During the activation of humoral immune responses, B cells acquire antigen for subsequent presentation to cognate T cells. Here we show that after mouse B cells accumulate antigen, it is maintained in a polarized distribution for extended periods in vivo. Using high-throughput imaging flow cytometry, we observed that this polarization is preserved during B cell division, promoting asymmetric antigen segregation among progeny. Antigen inheritance correlates with the ability of progeny to activate T cells: Daughter cells receiving larger antigen stores exhibit a prolonged capacity to present antigen, which renders them more effective in competing for T cell help. The generation of progeny with differential capacities for antigen presentation may have implications for somatic hypermutation and class switching during affinity maturation and as B cells commit to effector cell fates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thaunat, Olivier -- Granja, Aitor G -- Barral, Patricia -- Filby, Andrew -- Montaner, Beatriz -- Collinson, Lucy -- Martinez-Martin, Nuria -- Harwood, Naomi E -- Bruckbauer, Andreas -- Batista, Facundo D -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):475-9. doi: 10.1126/science.1214100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22282815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antigen Presentation ; Antigens/*analysis/*immunology ; B-Lymphocytes/cytology/*immunology ; Cell Division ; Cell Proliferation ; Cells, Cultured ; Coculture Techniques ; Computer Simulation ; Flow Cytometry ; *Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Immunological ; Muramidase/analysis/immunology ; T-Lymphocytes/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Universities, key to prosperity (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holliday, Charles O -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1482. doi: 10.1126/science.1225457. Epub 2012 Jun 14.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22700659" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics/organization & administration ; Financing, Government ; Research Support as Topic ; United States ; *Universities/economics/organization & administration
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  • 26
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    Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-08
    Description: Reestablishing homeostasis after tissue damage depends on the proper organization of stem cells and their progeny, though the repair mechanisms are unclear. The mammalian intestinal epithelium is well suited to approach this problem, as it is composed of well-delineated units called crypts of Lieberkuhn. We found that Wnt5a, a noncanonical Wnt ligand, was required for crypt regeneration after injury in mice. Unlike controls, Wnt5a-deficient mice maintained an expanded population of proliferative epithelial cells in the wound. We used an in vitro system to enrich for intestinal epithelial stem cells to discover that Wnt5a inhibited proliferation of these cells. Surprisingly, the effects of Wnt5a were mediated by activation of transforming growth factor-beta (TGF-beta) signaling. These findings suggest a Wnt5a-dependent mechanism for forming new crypt units to reestablish homeostasis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706630/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706630/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miyoshi, Hiroyuki -- Ajima, Rieko -- Luo, Christine T -- Yamaguchi, Terry P -- Stappenbeck, Thaddeus S -- 5T35DK074375/DK/NIDDK NIH HHS/ -- DK90251/DK/NIDDK NIH HHS/ -- P30-DK52574/DK/NIDDK NIH HHS/ -- R01 DK071619/DK/NIDDK NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2012 Oct 5;338(6103):108-13. doi: 10.1126/science.1223821. Epub 2012 Sep 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22956684" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Movement/drug effects/physiology ; Cell Proliferation/drug effects ; Cells, Cultured ; Colon/embryology/*injuries/*physiology ; Culture Media, Conditioned/pharmacology ; Homeostasis/drug effects/physiology ; Intestinal Mucosa/embryology/injuries/physiology ; Ligands ; Mesoderm/cytology/embryology ; Mice ; Mice, Knockout ; Receptor Tyrosine Kinase-like Orphan Receptors/metabolism ; Recombinant Proteins/pharmacology ; Signal Transduction ; Stem Cells/cytology/drug effects/physiology ; Tamoxifen/pharmacology ; Transforming Growth Factor beta/*metabolism ; Wnt Proteins/genetics/pharmacology/*physiology ; Wound Healing/drug effects/*physiology
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    Pigment pattern formation by contact-dependent depolarization (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-11
    Description: Although recent experimental studies have suggested that the interactions among the pigment cells play a key role in the skin pattern formation, details of the mechanism remain largely unknown. By using an in vitro cell culture system, we have detected interactions between the two pigment cell types, melanophores and xanthophores, in the zebrafish skin. During primary culture, the melanophore membrane transiently depolarizes when contacted with the dendrites of a xanthophore. This depolarization triggers melanophore migration to avoid further contact with the xanthophores. Cell depolarization and repulsive movement were not observed in pigment cells with the jaguar mutant, which shows defective segregation of melanophores and xanthophores. The depolarization-repulsion of wild-type pigment cells may explain the pigment cell behaviors generating the stripe pattern of zebrafish.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Inaba, Masafumi -- Yamanaka, Hiroaki -- Kondo, Shigeru -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):677. doi: 10.1126/science.1212821.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323812" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cell Movement ; Cells, Cultured ; Chromatophores/*physiology ; Melanophores/*physiology ; Membrane Potentials ; Mutation ; Skin/cytology ; *Skin Pigmentation ; Zebrafish/*anatomy & histology/physiology
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    Public health and biosecurity. The obligation to prevent the next dual-use controversy (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faden, Ruth R -- Karron, Ruth A -- New York, N.Y. -- Science. 2012 Feb 17;335(6070):802-4. doi: 10.1126/science.1219668. Epub 2012 Feb 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Johns Hopkins Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD 21205, USA. rfaden@jhu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323739" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information/ethics/legislation & jurisprudence ; Advisory Committees ; Animals ; *Biomedical Research/ethics/legislation & jurisprudence ; Bioterrorism/*prevention & control ; Birds ; Humans ; *Influenza A Virus, H5N1 Subtype ; Influenza in Birds/transmission/virology ; Influenza, Human/transmission/*virology ; Information Dissemination/*ethics/legislation & jurisprudence ; Internationality ; National Institutes of Health (U.S.) ; Pandemics/prevention & control ; Public Health/*ethics/legislation & jurisprudence ; Publishing/ethics ; Security Measures ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 29
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    Barry Commoner's place in history (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Egan, Michael -- New York, N.Y. -- Science. 2012 Nov 23;338(6110):1028. doi: 10.1126/science.338.6110.1028-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23180843" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information/*history ; Ecology/*history ; History, 20th Century ; History, 21st Century ; Humans ; Public Health/*history ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Retrospective. Lynn Margulis (1938-2011) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaechter, Moselio -- New York, N.Y. -- Science. 2012 Jan 20;335(6066):302. doi: 10.1126/science.1218027.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, San Diego State University, San Diego, CA 92182, USA. mschaech@sunstroke.sdsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22267805" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; *Eukaryotic Cells ; History, 20th Century ; History, 21st Century ; *Symbiosis ; United States
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    AAAS S&T policy fellows. Four decades on, fellows make global impact on science policy (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaffer, Carla -- Lempinen, Edward W -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1622.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23025002" target="_blank"〉PubMed〈/a〉
    Keywords: Fellowships and Scholarships/*trends ; History, 20th Century ; History, 21st Century ; *Internationality ; Research/*economics ; Societies, Scientific/history/*trends ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-02
    Description: The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes approximately 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain protein subunits, CLOCK and BMAL1. Here, we report the crystal structure of a complex containing the mouse CLOCK:BMAL1 bHLH-PAS domains at 2.3 A resolution. The structure reveals an unusual asymmetric heterodimer with the three domains in each of the two subunits--bHLH, PAS-A, and PAS-B--tightly intertwined and involved in dimerization interactions, resulting in three distinct protein interfaces. Mutations that perturb the observed heterodimer interfaces affect the stability and activity of the CLOCK:BMAL1 complex as well as the periodicity of the circadian oscillator. The structure of the CLOCK:BMAL1 complex is a starting point for understanding at an atomic level the mechanism driving the mammalian circadian clock.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694778/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694778/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Nian -- Chelliah, Yogarany -- Shan, Yongli -- Taylor, Clinton A -- Yoo, Seung-Hee -- Partch, Carrie -- Green, Carla B -- Zhang, Hong -- Takahashi, Joseph S -- R01 GM081875/GM/NIGMS NIH HHS/ -- R01 GM090247/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Jul 13;337(6091):189-94. doi: 10.1126/science.1222804. Epub 2012 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22653727" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors/*chemistry/genetics/metabolism ; Amino Acid Sequence ; Animals ; CLOCK Proteins/*chemistry/genetics/metabolism ; Cells, Cultured ; *Circadian Rhythm ; Crystallography, X-Ray ; DNA/metabolism ; HEK293 Cells ; Helix-Loop-Helix Motifs ; Humans ; Mice ; Models, Molecular ; Molecular Sequence Data ; Mutant Proteins/chemistry/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; Static Electricity ; *Transcriptional Activation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The final end of the final frontier? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lisse, Carey Michael -- McNutt, Ralph L Jr -- New York, N.Y. -- Science. 2012 Nov 30;338(6111):1149-50. doi: 10.1126/science.338.6111.1149-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23197514" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Capital Financing ; Government Programs/*economics ; *Planets ; Robotics/economics/methods ; Space Flight/*economics/methods ; United States ; United States National Aeronautics and Space Administration/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Benefits and risks of influenza research: lessons learned (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: Given the yearly challenge of seasonal influenza and the potential catastrophic consequences of future pandemics, the need for intensive basic and clinical influenza research is unquestionable. Although the fruits of decades of research have enabled dramatic improvements in our ability to prevent and treat influenza, many fundamental questions remain, including those related to the complex factors associated with host switching and transmission of influenza viruses. Recent public concern over two H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered intense discussion on dual-use research and the way forward.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Collins, Francis S -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1522-3. doi: 10.1126/science.1224305.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. afauci@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723407" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Biomedical Research ; Bioterrorism ; Disease Models, Animal ; Evolution, Molecular ; Ferrets ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/mortality/transmission/*virology ; Mutation ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; Public Health ; Public Policy ; *Publishing ; Reassortant Viruses/genetics/pathogenicity ; Risk Assessment ; Security Measures ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Mobilizing scientific societies (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2012 Dec 14;338(6113):1396. doi: 10.1126/science.1233700.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239700" target="_blank"〉PubMed〈/a〉
    Keywords: Attitude ; Schools/*economics/*standards ; Science/*education ; Societies, Scientific/*utilization ; Students/psychology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    Failure of skin-deep learning (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1263. doi: 10.1126/science.1233422.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224524" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Humans ; *Learning ; Science/*education ; Textbooks as Topic/*standards ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Thriving on common ground (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2012 Oct 26;338(6106):443. doi: 10.1126/science.1231652.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23112298" target="_blank"〉PubMed〈/a〉
    Keywords: Education/*economics/*trends ; Humans ; *Politics ; Science/*economics/*trends ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Task force's prevention advice proves hard to swallow. Interview by Eliot Marshall (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moyer, Virginia -- New York, N.Y. -- Science. 2012 Sep 21;337(6101):1468-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22997318" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Breast Neoplasms/diagnosis/*prevention & control ; *Early Detection of Cancer/statistics & numerical data ; Evidence-Based Medicine ; Female ; Health Policy ; Humans ; Male ; *Mammography/statistics & numerical data ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/diagnosis/*prevention & control ; Public Opinion ; United States ; United States Dept. of Health and Human Services/*organization & administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Marine conservation. Oh, baby: fight brews over U.S. import of beluga whales (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):180. doi: 10.1126/science.338.6104.180.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066051" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Beluga Whale ; *Endangered Species ; Russia ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Speak up for science funding (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leshner, Alan I -- Woolley, Mary -- New York, N.Y. -- Science. 2012 Nov 9;338(6108):722. doi: 10.1126/science.1232218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23139298" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Financing, Government ; National Institutes of Health (U.S.)/economics ; *Research Support as Topic ; *Science ; United States ; United States Government Agencies/*economics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2 (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: The endoplasmic reticulum (ER) is the primary organelle for folding and maturation of secretory and transmembrane proteins. Inability to meet protein-folding demand leads to "ER stress," and activates IRE1alpha, an ER transmembrane kinase-endoribonuclease (RNase). IRE1alpha promotes adaptation through splicing Xbp1 mRNA or apoptosis through incompletely understood mechanisms. Here, we found that sustained IRE1alpha RNase activation caused rapid decay of select microRNAs (miRs -17, -34a, -96, and -125b) that normally repress translation of Caspase-2 mRNA, and thus sharply elevates protein levels of this initiator protease of the mitochondrial apoptotic pathway. In cell-free systems, recombinant IRE1alpha endonucleolytically cleaved microRNA precursors at sites distinct from DICER. Thus, IRE1alpha regulates translation of a proapoptotic protein through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742121/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742121/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Upton, John-Paul -- Wang, Likun -- Han, Dan -- Wang, Eric S -- Huskey, Noelle E -- Lim, Lionel -- Truitt, Morgan -- McManus, Michael T -- Ruggero, Davide -- Goga, Andrei -- Papa, Feroz R -- Oakes, Scott A -- DK063720/DK/NIDDK NIH HHS/ -- DP2 OD001925/OD/NIH HHS/ -- DP2OD001925/OD/NIH HHS/ -- GM080783/GM/NIGMS NIH HHS/ -- P30 DK063720/DK/NIDDK NIH HHS/ -- R01 CA136577/CA/NCI NIH HHS/ -- R01 CA136717/CA/NCI NIH HHS/ -- R01 CA140456/CA/NCI NIH HHS/ -- R01 CA154916/CA/NCI NIH HHS/ -- R01 DK080955/DK/NIDDK NIH HHS/ -- R01 GM080783/GM/NIGMS NIH HHS/ -- R01CA136577/CA/NCI NIH HHS/ -- R01CA136717/CA/NCI NIH HHS/ -- R01CA140456/CA/NCI NIH HHS/ -- R01CA154916/CA/NCI NIH HHS/ -- R01DK080955/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042294" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; Animals ; Apoptosis ; Brefeldin A/pharmacology ; Caspase 2/*genetics/*metabolism ; Cell-Free System ; Cells, Cultured ; Cysteine Endopeptidases/*genetics/*metabolism ; Down-Regulation ; Endoplasmic Reticulum/metabolism ; *Endoplasmic Reticulum Stress ; Endoribonucleases/chemistry/genetics/*metabolism ; Enzyme Activation ; HEK293 Cells ; Humans ; Mice ; Mice, Knockout ; MicroRNAs/*metabolism ; Mutant Proteins ; Protein Biosynthesis ; Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism ; RNA Stability ; RNA, Messenger/genetics/metabolism ; Up-Regulation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Geophysics. India barred entry to U.S. author of seismic review (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bagla, Pallava -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1275. doi: 10.1126/science.338.6112.1275.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224534" target="_blank"〉PubMed〈/a〉
    Keywords: *Earthquakes ; India ; Risk ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Retrospective. Norman L. Letvin (1949-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabel, Gary J -- Wolinsky, Steven M -- Haynes, Barton F -- New York, N.Y. -- Science. 2012 Jun 29;336(6089):1653. doi: 10.1126/science.1225947.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. gnabel@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22745414" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*history ; Acquired Immunodeficiency Syndrome/*history ; Animals ; History, 20th Century ; History, 21st Century ; Humans ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Retrospective. Norton Zinder (1928-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lodish, Harvey -- Fedoroff, Nina -- New York, N.Y. -- Science. 2012 Mar 16;335(6074):1316. doi: 10.1126/science.1220682.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research and the Massachusetts Institute of Technology, Cambridge, MA 02142, USA. lodish@wi.mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22422973" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteriophages ; DNA, Recombinant ; History, 20th Century ; History, 21st Century ; Human Genome Project ; Molecular Biology/*history ; Transduction, Genetic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Biosecurity. Will flu papers lead to new research oversight? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- Malakoff, David -- New York, N.Y. -- Science. 2012 Jan 6;335(6064):20, 22. doi: 10.1126/science.335.6064.20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22223781" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Advisory Committees ; Animals ; Biomedical Research ; Bioterrorism/*prevention & control ; Humans ; Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity ; Influenza, Human/transmission ; International Cooperation ; Orthomyxoviridae Infections/*transmission/virology ; *Publishing ; *Security Measures ; United States ; World Health Organization
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    GM research. Charges fly, confusion reigns over golden rice study in Chinese children (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- Enserink, Martin -- New York, N.Y. -- Science. 2012 Sep 14;337(6100):1281. doi: 10.1126/science.337.6100.1281.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22984040" target="_blank"〉PubMed〈/a〉
    Keywords: Asian Continental Ancestry Group ; Child ; China ; Clinical Trials as Topic/economics/*ethics ; Humans ; National Institute of Diabetes and Digestive and Kidney Diseases ; (U.S.)/economics/ethics ; Oryza/*genetics ; *Plants, Genetically Modified ; Therapeutic Human Experimentation/economics/*ethics ; United States ; Vitamin A Deficiency/*diet therapy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 47
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    HIV/AIDS. Dreams meet realities at AIDS conference (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2012 Aug 3;337(6094):509-10. doi: 10.1126/science.337.6094.509.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22859460" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy/*epidemiology/immunology ; Anti-Retroviral Agents/*therapeutic use ; *Hiv ; Humans ; Immune System/immunology ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Profile: Stephen Friend. The visionary (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):651-3. doi: 10.1126/science.335.6069.651.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323794" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Animals ; *Computational Biology ; Computer Simulation ; Databases, Factual ; *Drug Discovery ; History, 20th Century ; History, 21st Century ; Humans ; *Information Dissemination ; Software ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Personalized medicine. New cystic fibrosis drug offers hope, at a price (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):645. doi: 10.1126/science.335.6069.645.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323790" target="_blank"〉PubMed〈/a〉
    Keywords: Aminophenols/economics/*therapeutic use ; Cystic Fibrosis/*drug therapy/*genetics ; Cystic Fibrosis Transmembrane Conductance ; Regulator/chemistry/*genetics/metabolism ; Drug Approval ; Drug Costs ; Humans ; Molecular Targeted Therapy ; Mutation ; Precision Medicine ; Quinolones/economics/*therapeutic use ; Small Molecule Libraries ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Out of the tropics: the Pacific, Great Basin lakes, and late Pleistocene water cycle in the western United States (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-29
    Description: The water cycle in the western United States changed dramatically over glacial cycles. In the past 20,000 years, higher precipitation caused desert lakes to form which have since dried out. Higher glacial precipitation has been hypothesized to result from a southward shift of Pacific winter storm tracks. We compared Pacific Ocean data to lake levels from the interior west and found that Great Basin lake high stands are older than coastal wet periods at the same latitude. Westerly storms were not the source of high precipitation. Instead, air masses from the tropical Pacific were transported northward, bringing more precipitation into the Great Basin when coastal California was still dry. The changing climate during the deglaciation altered precipitation source regions and strongly affected the regional water cycle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyle, Mitchell -- Heusser, Linda -- Ravelo, Christina -- Yamamoto, Masanobu -- Barron, John -- Diffenbaugh, Noah S -- Herbert, Timothy -- Andreasen, Dyke -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1629-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oceanography, Texas A&M University, College Station, TX 77843, USA. mlyle@ocean.tamu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019644" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Climate Change ; *Ice Cover ; *Lakes ; Rain ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Retrospective. Robert R. Sokal (1926-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Futuyma, Douglas J -- New York, N.Y. -- Science. 2012 May 18;336(6083):816. doi: 10.1126/science.1224101.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, Life Sciences Laboratories, Stony Brook University, Stony Brook, NY 11794-5245, USA. futuyma@life.bio.sunysb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22605743" target="_blank"〉PubMed〈/a〉
    Keywords: Austria ; Biological Evolution ; Biology/*history ; Biostatistics/*history ; Classification ; Ecology/history ; History, 20th Century ; History, 21st Century ; United States
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    IBI series winner. Student-directed discovery of the plant microbiome and its products (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bascom-Slack, Carol A -- Arnold, A Elizabeth -- Strobel, Scott A -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Oct 26;338(6106):485-6. doi: 10.1126/science.1215227.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23112324" target="_blank"〉PubMed〈/a〉
    Keywords: Biodiversity ; Endophytes/*isolation & purification ; Fungi/isolation & purification ; *Metagenome ; Microbiology/*education ; Plants/*microbiology ; *Program Development ; Research/*education ; United States ; Universities
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Removal of shelterin reveals the telomere end-protection problem (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-05
    Description: The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the end-protection problem, we removed the whole shelterin complex from mouse telomeres through conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells. The data reveal two DNA damage response pathways not previously observed upon deletion of individual shelterin proteins. The shelterin-free telomeres are processed by microhomology-mediated alternative-NHEJ when Ku70/80 is absent and are attacked by nucleolytic degradation in the absence of 53BP1. The data establish that the end-protection problem is specified by six pathways [ATM (ataxia telangiectasia mutated) and ATR (ataxia telangiectasia and Rad3 related) signaling, classical-NHEJ, alt-NHEJ, homologous recombination, and resection] and show how shelterin acts with general DNA damage response factors to solve this problem.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477646/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477646/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sfeir, Agnel -- de Lange, Titia -- AG016642/AG/NIA NIH HHS/ -- GM49046/GM/NIGMS NIH HHS/ -- R01 AG016642/AG/NIA NIH HHS/ -- R01 CA076027/CA/NCI NIH HHS/ -- R37 GM049046/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 May 4;336(6081):593-7. doi: 10.1126/science.1218498.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22556254" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Nuclear/genetics/metabolism ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cells, Cultured ; Chromosomal Proteins, Non-Histone/metabolism ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; DNA Ligases/metabolism ; DNA Repair ; DNA-Binding Proteins/genetics/metabolism ; Homologous Recombination ; Mice ; Mice, Knockout ; Poly(ADP-ribose) Polymerases/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Telomere/*metabolism/ultrastructure ; *Telomere Homeostasis ; Telomere-Binding Proteins/genetics/*metabolism ; Telomeric Repeat Binding Protein 1/genetics/metabolism ; Telomeric Repeat Binding Protein 2/genetics/metabolism ; Tumor Suppressor Proteins/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Regulating the boundaries of dual-use research (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: A new U.S. policy for dual-use life science research defines what is permissible by scientists and the government. However, further negotiations will be needed as governments realize the consequences of such boundaries for research and society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, Mark S -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1523-5. doi: 10.1126/science.1221285.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program on Scientific Responsibility, Human Rights and Law, American Association for the Advancement of Science, Washington, DC 20005, USA. mfrankel@aaas.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723408" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Animals ; Biomedical Research/*legislation & jurisprudence ; Financing, Government ; *Government Regulation ; Humans ; Influenza A Virus, H5N1 Subtype ; Information Dissemination ; International Cooperation ; *Public Policy ; *Publishing ; Research Support as Topic ; Security Measures ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Biomedical research policy. NIH funding shifts with disease lobbying, study suggests (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):181. doi: 10.1126/science.338.6104.181.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066052" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Disease/*economics ; *Financing, Organized ; Humans ; *Lobbying ; National Institutes of Health (U.S.)/*economics ; Policy ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Global research universities. How to go global (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1602-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019626" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*trends ; Humans ; *International Cooperation ; *Laboratories ; *Neoplasms ; United States ; Vietnam
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Environmental health. Cancers join list of illnesses linked to 9/11 attacks (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Sep 21;337(6101):1447.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22997301" target="_blank"〉PubMed〈/a〉
    Keywords: Delivery of Health Care/*legislation & jurisprudence ; Eligibility Determination ; Environmental Exposure/*adverse effects ; Government Programs/*legislation & jurisprudence ; Humans ; National Institute for Occupational Safety and Health (U.S.)/*legislation & ; jurisprudence ; Neoplasms/*etiology ; New York City ; Occupational Diseases/*etiology ; *September 11 Terrorist Attacks ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Breakthrough of the year. A year on, the H5N1 debate remains infectious, with no end in sight (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2012 Dec 21;338(6114):1533. doi: 10.1126/science.338.6114.1533.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23258869" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biomedical Research/economics ; Financing, Government ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/transmission/*virology ; Mammals ; Orthomyxoviridae Infections/transmission/*virology ; Publishing ; Research Support as Topic ; Security Measures ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. conflict regulations. Scientists sue to halt financial disclosure rule (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):632. doi: 10.1126/science.337.6095.632.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879474" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Conflict of Interest ; Databases, Factual ; Disclosure/*legislation & jurisprudence ; Jurisprudence ; National Institutes of Health (U.S.)/economics/*legislation & ; jurisprudence/organization & administration ; *Research Personnel/economics/legislation & jurisprudence ; United States ; United States Government Agencies/economics/*legislation & ; jurisprudence/organization & administration ; United States National Aeronautics and Space ; Administration/economics/*legislation & jurisprudence/organization & ; administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. election. Change versus experience? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):875. doi: 10.1126/science.338.6109.875.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23161967" target="_blank"〉PubMed〈/a〉
    Keywords: Research Support as Topic ; Science/*economics/education/*legislation & jurisprudence ; United States
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    Retrospective. Renato Dulbecco (1914-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baltimore, David -- New York, N.Y. -- Science. 2012 Mar 30;335(6076):1587. doi: 10.1126/science.1221692.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, California Institute of Technology, Pasadena, CA 91125, USA. baltimo@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22461601" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; History, 21st Century ; Italy ; Molecular Biology/*history ; Nobel Prize ; United States ; Virology/*history
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    dSarm/Sarm1 is required for activation of an injury-induced axon death pathway (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-09
    Description: Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently blocking axon self-destruction have not been described. Here, we show that loss of the Drosophila Toll receptor adaptor dSarm (sterile alpha/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wallerian degeneration for weeks after axotomy. Severed mouse Sarm1 null axons exhibit remarkable long-term survival both in vivo and in vitro, indicating that Sarm1 prodegenerative signaling is conserved in mammals. Our results provide direct evidence that axons actively promote their own destruction after injury and identify dSarm/Sarm1 as a member of an ancient axon death signaling pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osterloh, Jeannette M -- Yang, Jing -- Rooney, Timothy M -- Fox, A Nicole -- Adalbert, Robert -- Powell, Eric H -- Sheehan, Amy E -- Avery, Michelle A -- Hackett, Rachel -- Logan, Mary A -- MacDonald, Jennifer M -- Ziegenfuss, Jennifer S -- Milde, Stefan -- Hou, Ying-Ju -- Nathan, Carl -- Ding, Aihao -- Brown, Robert H Jr -- Conforti, Laura -- Coleman, Michael -- Tessier-Lavigne, Marc -- Zuchner, Stephan -- Freeman, Marc R -- 5R01-NS050557-05/NS/NINDS NIH HHS/ -- AI030165/AI/NIAID NIH HHS/ -- R01NS059991/NS/NINDS NIH HHS/ -- R01NS072248/NS/NINDS NIH HHS/ -- RC2-NS070-342/NS/NINDS NIH HHS/ -- U54NS065712/NS/NINDS NIH HHS/ -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Jul 27;337(6093):481-4. doi: 10.1126/science.1223899. Epub 2012 Jun 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22678360" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Apoptosis ; Armadillo Domain Proteins/analysis/*genetics/*physiology ; Axons/*physiology/ultrastructure ; Axotomy ; Cell Survival ; Cells, Cultured ; Cytoskeletal Proteins/analysis/*genetics/*physiology ; Denervation ; Drosophila/embryology/genetics/physiology ; Drosophila Proteins/analysis/*genetics/*physiology ; Mice ; Mutation ; Neurons/*physiology ; Sciatic Nerve/injuries/physiology ; Signal Transduction ; Superior Cervical Ganglion/cytology ; Tissue Culture Techniques ; *Wallerian Degeneration
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    Clinical medicine. Biomarker tests need closer scrutiny, IOM concludes (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2012 Mar 30;335(6076):1554. doi: 10.1126/science.335.6076.1554.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22461579" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/therapeutic use ; Biomedical Research/*standards ; Clinical Trials as Topic ; Conflict of Interest ; *Gene Expression Profiling ; Humans ; *Institute of Medicine (U.S.) ; *Molecular Diagnostic Techniques ; Neoplasms/*drug therapy/genetics ; Precision Medicine ; Reproducibility of Results ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. elections. In a torrent of campaign rhetoric, hints of science policy (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2012 Sep 14;337(6100):1284-5. doi: 10.1126/science.337.6100.1284.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22984042" target="_blank"〉PubMed〈/a〉
    Keywords: Climate Change/*economics ; *Emigration and Immigration ; *Policy ; Science/*economics/*trends ; United States
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    Gulf oil spill. Researchers hail new restoration program funds (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2012 Jul 6;337(6090):22. doi: 10.1126/science.337.6090.22.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22767905" target="_blank"〉PubMed〈/a〉
    Keywords: *Ecosystem ; Gulf of Mexico ; Industry/*economics/legislation & jurisprudence ; *Petroleum ; *Petroleum Pollution/economics/legislation & jurisprudence ; United States ; *Water Pollution, Chemical/economics/legislation & jurisprudence ; *Wetlands
    Print ISSN: 0036-8075
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    Cell Biology. Using cell-to-cell variability--a new era in molecular biology (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pelkmans, Lucas -- New York, N.Y. -- Science. 2012 Apr 27;336(6080):425-6. doi: 10.1126/science.1222161.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. lucas.pelkmans@imls.uzh.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22539709" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Biology ; Cell Communication ; *Cell Physiological Processes ; Cells, Cultured ; *Cellular Microenvironment ; *Cytological Techniques ; Humans ; Molecular Biology/methods ; Phenotype ; *Single-Cell Analysis
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    Developmental biology. Physical biology returns to morphogenesis (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keller, Ray -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):201-3. doi: 10.1126/science.1230718.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Virginia, Charlottesville, VA 22903, USA. rek3k@virginia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066066" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura/anatomy & histology/embryology ; *Biophysical Phenomena ; Cell Adhesion/genetics ; Cell Culture Techniques ; *Cell Movement ; Cells, Cultured ; Cytoskeleton/physiology/ultrastructure ; Embryo, Nonmammalian/cytology/drug effects/physiology ; Gastrulation ; Green Fluorescent Proteins/analysis ; *Morphogenesis ; Recombinant Fusion Proteins/analysis ; Sodium Chloride/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Science and security. U.S. agencies to start screening biomedical proposals for dual use (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2012 Apr 6;336(6077):21. doi: 10.1126/science.336.6077.21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22491834" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/economics/*legislation & jurisprudence ; Financing, Government ; *Government Regulation ; National Institutes of Health (U.S.) ; *Public Policy ; Publishing ; *Research Support as Topic ; *Security Measures ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    NIH basics (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Francis S -- New York, N.Y. -- Science. 2012 Aug 3;337(6094):503. doi: 10.1126/science.1227820.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22859455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*economics ; Drug Discovery/economics ; Humans ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Hypoxia triggers meiotic fate acquisition in maize (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-24
    Description: Evidence from confocal microscopic reconstruction of maize anther development in fertile, mac1 (excess germ cells), and msca1 (no germ cells) flowers indicates that the male germ line is multiclonal and uses the MAC1 protein to organize the somatic niche. Furthermore, we identified redox status as a determinant of germ cell fate, defining a mechanism distinct from the animal germ cell lineage. Decreasing oxygen or H(2)O(2) increases germ cell numbers, stimulates superficial germ cell formation, and rescues germinal differentiation in msca1 flowers. Conversely, oxidizing environments inhibit germ cell specification and cause ectopic differentiation in deeper tissues. We propose that hypoxia, arising naturally within growing anther tissue, acts as a positional cue to set germ cell fate.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101383/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101383/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelliher, Timothy -- Walbot, Virginia -- 5-T32-GM008412-17/GM/NIGMS NIH HHS/ -- T32 GM008412/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Jul 20;337(6092):345-8. doi: 10.1126/science.1220080.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Stanford University, Stanford, CA 94305, USA. tkellih1@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22822150" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis ; Cell Hypoxia ; Cells, Cultured ; Germ Cells/metabolism ; *Meiosis ; Oxygen/*metabolism/pharmacology ; Plant Epidermis/cytology/drug effects/metabolism ; Water/metabolism/pharmacology ; Zea mays/*cytology/drug effects/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. science budget. Kansas veterinary biosecurity lab trampled in spending plan (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2012 Feb 24;335(6071):903. doi: 10.1126/science.335.6071.903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22362981" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Diseases ; Animals ; *Biomedical Research/economics ; Budgets ; *Containment of Biohazards/economics ; Financing, Government ; Kansas ; Laboratories/*economics ; United States ; United States Department of Homeland Security/economics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Bioinformatics. New way to look at life (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2012 Oct 19;338(6105):317. doi: 10.1126/science.338.6105.317.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23087224" target="_blank"〉PubMed〈/a〉
    Keywords: Computational Biology/*methods ; England ; *Internet ; *Phylogeny ; *Software ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Retrospective. Elinor Ostrom (1933-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, Rick K -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):661. doi: 10.1126/science.1227725.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Political Science, Rice University, Houston, TX 77251-1892, USA. rkw@rice.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879496" target="_blank"〉PubMed〈/a〉
    Keywords: Economics/history ; History, 20th Century ; History, 21st Century ; Nobel Prize ; Politics ; Sociology/history ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The dual-use conundrum (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berg, Paul -- New York, N.Y. -- Science. 2012 Sep 14;337(6100):1273. doi: 10.1126/science.1229789.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22984033" target="_blank"〉PubMed〈/a〉
    Keywords: *Accident Prevention ; Animals ; Biohazard Release/*prevention & control ; Biomedical Research/*ethics ; Birds ; *Containment of Biohazards ; DNA, Recombinant/*genetics ; Guidelines as Topic ; Humans ; Influenza A Virus, H5N1 Subtype/genetics/pathogenicity ; Influenza in Birds/prevention & control/transmission ; Influenza, Human/prevention & control/transmission ; Information Dissemination ; Organisms, Genetically Modified/*genetics ; Policy ; Publications ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Patent law. Law and science collide over human gene patents (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook-Deegan, Robert -- P50 HG003391/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 9;338(6108):745-7. doi: 10.1126/science.1229854.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA. bob.cd@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23139317" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; *Dna ; *Genes ; Genes, BRCA1 ; Genes, BRCA2 ; Humans ; Inventions ; Patents as Topic/*legislation & jurisprudence ; *Supreme Court Decisions ; United States
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    Implementing the new U.S. dual-use policy (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: After a decade of intensive policy discussions on the topic of dual-use research of concern (DURC) in the life sciences, there has been a lack of consensus on how to practically define DURC; whether it is feasible to identify and regulate DURC experiments; how to address the risks associated with DURC; and how to balance this risk with the necessity of fostering life sciences research for public health and biodefense. The publication of two avian influenza studies has brought the DURC issue back into sharp focus and has resulted in a new set of federal guidelines. However, the new DURC policy raises questions regarding whether this is the best policy solution to a complicated biosecurity concern.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolinetz, Carrie D -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1525-7. doi: 10.1126/science.1223995.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Association of American Universities, Washington, DC 20005, USA. carrie_wolinetz@aau.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723409" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Biological Science Disciplines ; *Biomedical Research/classification/legislation & jurisprudence ; Bioterrorism/prevention & control ; *Government Regulation ; Humans ; Influenza A Virus, H5N1 Subtype ; International Cooperation ; National Institutes of Health (U.S.) ; Public Health ; *Public Policy ; *Research/classification/legislation & jurisprudence ; Risk Assessment ; *Security Measures ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Planetary science. Peering inside the moon to read its earliest history (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1272. doi: 10.1126/science.338.6112.1272.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224531" target="_blank"〉PubMed〈/a〉
    Keywords: *Gravitation ; *Moon ; *Space Flight ; United States ; United States National Aeronautics and Space Administration
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    Public health and biosecurity. Adaptations of avian flu virus are a cause for concern (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berns, Kenneth I -- Casadevall, Arturo -- Cohen, Murray L -- Ehrlich, Susan A -- Enquist, Lynn W -- Fitch, J Patrick -- Franz, David R -- Fraser-Liggett, Claire M -- Grant, Christine M -- Imperiale, Michael J -- Kanabrocki, Joseph -- Keim, Paul S -- Lemon, Stanley M -- Levy, Stuart B -- Lumpkin, John R -- Miller, Jeffery F -- Murch, Randall -- Nance, Mark E -- Osterholm, Michael T -- Relman, David A -- Roth, James A -- Vidaver, Anne K -- New York, N.Y. -- Science. 2012 Feb 10;335(6069):660-1. doi: 10.1126/science.1217994. Epub 2012 Jan 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics Institute, University of Florida, Gainesville, FL 32611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22294736" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Advisory Committees ; Animals ; Biological Warfare Agents ; Containment of Biohazards ; Humans ; Influenza A Virus, H5N1 Subtype/*pathogenicity ; Influenza, Human/epidemiology/transmission/*virology ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; *Public Health ; *Publishing ; Risk Assessment ; Security Measures ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Profile: Jim Toomey. LOL and a touch of science, too (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2012 Jul 6;337(6090):28-9. doi: 10.1126/science.337.6090.28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22767909" target="_blank"〉PubMed〈/a〉
    Keywords: *Aquatic Organisms ; *Cartoons as Topic/history ; *Conservation of Natural Resources ; History, 20th Century ; History, 21st Century ; United States ; *Wit and Humor as Topic/history
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    Stem cells. U.S. regulation of stem cells as medical products (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sipp, Douglas -- Turner, Leigh -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1296-7. doi: 10.1126/science.1229918.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉RIKEN Center for Developmental Biology, Kobe 12345, Japan. sipp@cdb.riken.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224541" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Products ; Commerce ; Consumer Product Safety/*legislation & jurisprudence ; *Federal Government ; *Guidelines as Topic ; Humans ; Mesenchymal Stromal Cells ; Safety ; Stem Cell Transplantation/*legislation & jurisprudence ; *Stem Cells ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Patents. U.S. appeals court hears gene patent arguments (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2012 Jul 20;337(6092):277-8. doi: 10.1126/science.337.6092.277.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22822118" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/legislation & jurisprudence ; Breast Neoplasms/*diagnosis/genetics ; DNA/genetics ; Female ; *Genes, BRCA1 ; *Genes, BRCA2 ; Genetics, Medical/*legislation & jurisprudence ; Humans ; Patents as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Astrobiology. In the hunt for the red planet's dirtiest secret (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2012 Aug 31;337(6098):1032-3. doi: 10.1126/science.337.6098.1032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22936751" target="_blank"〉PubMed〈/a〉
    Keywords: *Mars ; United States ; United States National Aeronautics and Space Administration
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    Making science education relevant (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wulf, William A -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):193. doi: 10.1126/science.338.6104.193-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066059" target="_blank"〉PubMed〈/a〉
    Keywords: Engineering/*education ; *Public Policy ; Science/*education ; United States ; *Universities
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    Nobel Memorial Prize in economic sciences. Economics Nobel honors matchmaking finesse (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2012 Oct 19;338(6105):314. doi: 10.1126/science.338.6105.314.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23087221" target="_blank"〉PubMed〈/a〉
    Keywords: *Economics ; *Game Theory ; *Nobel Prize ; United States
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    Research philanthropy. Billionaire restores funding for novel biomedical network (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):873-4. doi: 10.1126/science.338.6109.873.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23161965" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Fund Raising ; Neoplasms/economics ; United States
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    Are we winning the war against posttraumatic stress disorder? (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-19
    Description: The most methodologically rigorous epidemiological study on American military personnel deployed to Iraq and Afghanistan found that 4.3% of troops developed posttraumatic stress disorder (PTSD). Among deployed combatants, 7.6% developed PTSD, whereas 1.4% of deployed noncombatants did so. The U.S. Department of Veterans Affairs has launched a program ensuring that all veterans with PTSD will receive evidence-based cognitive-behavioral therapy, and the Army has developed Battlemind postdeployment early interventions that reduce risk for the disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNally, Richard J -- New York, N.Y. -- Science. 2012 May 18;336(6083):872-4. doi: 10.1126/science.1222069.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Harvard University, Cambridge, MA 02138, USA. rjm@wjh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22605766" target="_blank"〉PubMed〈/a〉
    Keywords: *Afghan Campaign 2001- ; Cognitive Therapy ; Humans ; *Iraq War, 2003-2011 ; *Military Personnel/psychology/statistics & numerical data ; Randomized Controlled Trials as Topic ; Risk Factors ; *Stress Disorders, Post-Traumatic/epidemiology/prevention & control/therapy ; United States ; United States Department of Veterans Affairs ; Veterans/psychology/statistics & numerical data
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (PF4 or CXCL4) and the erythrocyte Duffy-antigen receptor (Fy) are necessary for platelet-mediated killing of Plasmodium falciparum parasites. PF4 is released by platelets on contact with parasitized red cells, and the protein directly kills intraerythrocytic parasites. This function for PF4 is critically dependent on Fy, which binds PF4. Genetic disruption of Fy expression inhibits binding of PF4 to parasitized cells and concomitantly prevents parasite killing by both human platelets and recombinant human PF4. The protective function afforded by platelets during a malarial infection may therefore be compromised in Duffy-negative individuals, who do not express Fy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMorran, Brendan J -- Wieczorski, Laura -- Drysdale, Karen E -- Chan, Jo-Anne -- Huang, Hong Ming -- Smith, Clare -- Mitiku, Chalachew -- Beeson, James G -- Burgio, Gaetan -- Foote, Simon J -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1348-51. doi: 10.1126/science.1228892.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia. brendan.mcmorran@mq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224555" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Platelets/*immunology ; Cells, Cultured ; Duffy Blood-Group System/genetics/*immunology ; Erythrocytes/*parasitology ; Humans ; *Malaria, Falciparum/blood/immunology/parasitology ; Plasmodium falciparum/drug effects/growth & development/*immunology ; Platelet Factor 4/genetics/*immunology/pharmacology ; Receptors, Cell Surface/genetics/*immunology ; Recombinant Proteins/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    History of science. A golden era of Nobel laureates (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, Joseph L -- Brown, Michael S -- New York, N.Y. -- Science. 2012 Nov 23;338(6110):1033-4. doi: 10.1126/science.1231699.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA. joe.goldstein@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23180848" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*history/trends ; Education, Medical/history/trends ; History, 20th Century ; History, 21st Century ; National Institutes of Health (U.S.)/*history ; *Nobel Prize ; Translational Medical Research/history/trends ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-01
    Description: Notch signaling affects many developmental and cellular processes and has been implicated in congenital disorders, stroke, and numerous cancers. The Notch receptor binds its ligands Delta and Serrate and is able to discriminate between them in different contexts. However, the specific domains in Notch responsible for this selectivity are poorly defined. Through genetic screens in Drosophila, we isolated a mutation, Notch(jigsaw), that affects Serrate- but not Delta-dependent signaling. Notch(jigsaw) carries a missense mutation in epidermal growth factor repeat-8 (EGFr-8) and is defective in Serrate binding. A homologous point mutation in mammalian Notch2 also exhibits defects in signaling of a mammalian Serrate homolog, Jagged1. Hence, an evolutionarily conserved valine in EGFr-8 is essential for ligand selectivity and provides a molecular handle to study numerous Notch-dependent signaling events.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663443/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663443/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamamoto, Shinya -- Charng, Wu-Lin -- Rana, Nadia A -- Kakuda, Shinako -- Jaiswal, Manish -- Bayat, Vafa -- Xiong, Bo -- Zhang, Ke -- Sandoval, Hector -- David, Gabriela -- Wang, Hao -- Haltiwanger, Robert S -- Bellen, Hugo J -- 1RC4GM096355-01/GM/NIGMS NIH HHS/ -- 5K12GM084897/GM/NIGMS NIH HHS/ -- 5P30HD024064/HD/NICHD NIH HHS/ -- 5R01GM061126-12/GM/NIGMS NIH HHS/ -- 5R01GM067858/GM/NIGMS NIH HHS/ -- 5T32-HD055200/HD/NICHD NIH HHS/ -- K12 GM084897/GM/NIGMS NIH HHS/ -- P30 HD024064/HD/NICHD NIH HHS/ -- R01 GM061126/GM/NIGMS NIH HHS/ -- R01 GM067858/GM/NIGMS NIH HHS/ -- RC4 GM096355/GM/NIGMS NIH HHS/ -- T32 HD055200/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Nov 30;338(6111):1229-32. doi: 10.1126/science.1228745.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23197537" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Calcium-Binding Proteins/*metabolism ; Cells, Cultured ; DNA Mutational Analysis ; Drosophila Proteins/*genetics/*metabolism ; Drosophila melanogaster/genetics/*metabolism ; Epidermal Growth Factor/genetics ; Evolution, Molecular ; Humans ; Intercellular Signaling Peptides and Proteins/*metabolism ; Intracellular Signaling Peptides and Proteins/*metabolism ; Ligands ; Male ; Membrane Proteins/*metabolism ; Methionine/genetics ; Molecular Sequence Data ; Mutation ; Receptor, Notch2/genetics/metabolism ; Receptors, Notch/*genetics/*metabolism ; Tandem Repeat Sequences/genetics ; Valine/genetics ; X Chromosome/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Science funding. NSF's 'Big Pitch' tests anonymized grant reviews (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2012 May 25;336(6084):969-70. doi: 10.1126/science.336.6084.969.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22628627" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; *Peer Review, Research ; United States ; *United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Newsmaker interview: John Grunsfeld. NASA's spacefaring science chief sets a new course for Mars. Interview by Yudhijit Bhattacharjee (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grunsfeld, John -- New York, N.Y. -- Science. 2012 Aug 3;337(6094):511-2. doi: 10.1126/science.337.6094.511.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22859462" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Mars ; Space Flight/*economics/*trends ; United States ; United States National Aeronautics and Space Administration/*economics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Retrospective. Aaron Shatkin (1934-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sonenberg, Nahum -- Filipowicz, Witold -- New York, N.Y. -- Science. 2012 Jul 20;337(6092):309. doi: 10.1126/science.1226820.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, McGill University, Goodman Cancer Research Center, Montreal, Quebec H3A 1A3, Canada. nahum.sonenberg@mcgill.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22822142" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Gene Expression Regulation ; History, 20th Century ; History, 21st Century ; Humans ; RNA Caps/*history/physiology ; RNA Stability ; RNA, Messenger/chemistry/history/metabolism ; United States ; Virology/*history
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Retrospective. Roy J. Britten (1919-2012) (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, Eric H -- New York, N.Y. -- Science. 2012 Mar 9;335(6073):1183. doi: 10.1126/science.1220828.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22403381" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/chemistry ; Evolution, Molecular ; Gene Expression Regulation ; Genomics/history ; History, 20th Century ; History, 21st Century ; Molecular Biology/*history ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Equal opportunity. Action urged to curb racial bias in NIH grants (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Price, Michael -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1490. doi: 10.1126/science.336.6088.1490.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723383" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *African Continental Ancestry Group ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    U.S. science policy. White House panel urges agencies to take more risks (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2012 Dec 7;338(6112):1274. doi: 10.1126/science.338.6112.1274.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23224533" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; National Institutes of Health (U.S.)/*economics ; *Policy ; Science/*economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Biomedical careers. Young researchers deserve more support, reviews say (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Price, Michael -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1489-90. doi: 10.1126/science.336.6088.1489.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723382" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Education, Graduate ; *Fellowships and Scholarships ; *Mentors ; National Institutes of Health (U.S.) ; *Research Personnel/economics/education ; *Training Support ; United States
    Print ISSN: 0036-8075
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    Science and regulation. FDA's approach to regulation of products of nanotechnology (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamburg, Margaret A -- New York, N.Y. -- Science. 2012 Apr 20;336(6079):299-300. doi: 10.1126/science.1205441.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U.S. Food and Drug Administration, Silver Spring, MD 20993, USA. margaret.hamburg@fda.hhs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22517845" target="_blank"〉PubMed〈/a〉
    Keywords: *Consumer Product Safety ; Cosmetics ; Drug Approval/legislation & jurisprudence ; Government Regulation ; *Nanostructures ; Nanotechnology/*legislation & jurisprudence ; Product Surveillance, Postmarketing ; Public Policy ; United States ; United States Food and Drug Administration/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-15
    Description: Actin and spectrin play important roles in neurons, but their organization in axons and dendrites remains unclear. We used stochastic optical reconstruction microscopy to study the organization of actin, spectrin, and associated proteins in neurons. Actin formed ringlike structures that wrapped around the circumference of axons and were evenly spaced along axonal shafts with a periodicity of ~180 to 190 nanometers. This periodic structure was not observed in dendrites, which instead contained long actin filaments running along dendritic shafts. Adducin, an actin-capping protein, colocalized with the actin rings. Spectrin exhibited periodic structures alternating with those of actin and adducin, and the distance between adjacent actin-adducin rings was comparable to the length of a spectrin tetramer. Sodium channels in axons were distributed in a periodic pattern coordinated with the underlying actin-spectrin-based cytoskeleton.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815867/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815867/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Ke -- Zhong, Guisheng -- Zhuang, Xiaowei -- R01 GM096450/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Jan 25;339(6118):452-6. doi: 10.1126/science.1232251. Epub 2012 Dec 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23239625" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Capping Proteins/chemistry/ultrastructure ; Actin Cytoskeleton/chemistry/ultrastructure ; Actins/chemistry/*ultrastructure ; Animals ; Axons/*chemistry/*ultrastructure ; Calmodulin-Binding Proteins/chemistry/*ultrastructure ; Cells, Cultured ; Cytoskeleton/*chemistry/*ultrastructure ; Dendrites/chemistry/ultrastructure ; Hippocampus/ultrastructure ; Image Processing, Computer-Assisted ; Microscopy, Fluorescence/methods ; Neurons/chemistry/ultrastructure ; Protein Multimerization ; Rats ; Rats, Wistar ; Sodium Channels/chemistry/ultrastructure ; Spectrin/chemistry/*ultrastructure
    Print ISSN: 0036-8075
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    Turing centenary: The dawn of computing (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dyson, George -- England -- Nature. 2012 Feb 22;482(7386):459-60. doi: 10.1038/482459a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gdyson@ias.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22358810" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines/history ; Computers/*history ; History, 17th Century ; History, 20th Century ; Logic ; London ; Mathematics/history ; Research Design ; United States ; World War II
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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    David Sayre (1924-2012) (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-04-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirz, Janos -- Miao, Jianwei -- England -- Nature. 2012 Apr 4;484(7392):38. doi: 10.1038/484038a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stony Brook University, New York, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22481349" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/history ; Crystallography, X-Ray/*history ; Great Britain ; History, 20th Century ; Physics/history ; Spouses ; United States ; X-Rays
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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