Publication Date:
2012-10-09
Description:
Although synaptic transmission may be unidirectional, the establishment of synaptic connections with specific properties can involve bidirectional signaling. Pyramidal neurons in the hippocampus form functionally distinct synapses onto two types of interneurons. Excitatory synapses onto oriens-lacunosum moleculare (O-LM) interneurons are facilitating and have a low release probability, whereas synapses onto parvalbumin interneurons are depressing and have a high release probability. Here, we show that the extracellular leucine-rich repeat fibronectin containing 1 (Elfn1) protein is selectively expressed by O-LM interneurons and regulates presynaptic release probability to direct the formation of highly facilitating pyramidal-O-LM synapses. Thus, postsynaptic expression of Elfn1 in O-LM interneurons regulates presynaptic release probability, which confers target-specific synaptic properties to pyramidal cell axons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sylwestrak, Emily L -- Ghosh, Anirvan -- R01 NS067216/NS/NINDS NIH HHS/ -- R01NS067216/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Oct 26;338(6106):536-40. doi: 10.1126/science.1222482. Epub 2012 Oct 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0366, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042292" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/metabolism
;
CA1 Region, Hippocampal/*metabolism
;
Cells, Cultured
;
Gene Knockdown Techniques
;
Green Fluorescent Proteins/genetics/metabolism
;
HEK293 Cells
;
Humans
;
Interneurons/*metabolism
;
Mice
;
Nerve Tissue Proteins/genetics/*metabolism
;
RNA, Small Interfering/metabolism
;
Rats
;
Rats, Inbred LEC
;
Synapses/genetics/*metabolism
;
Synaptic Transmission
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
