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  • 1
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 2
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2014-08-15
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 3
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    Paris : Éditions de l Atelier | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: French
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  • 4
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 5
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: article , doc-type:article
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  • 6
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 7
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 8
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 9
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: report , doc-type:report
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  • 10
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    Bielefeld : Kleine | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 11
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 12
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: workingpaper , doc-type:workingPaper
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  • 13
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 14
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    Opladen : Leske + Budrich | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2014-08-15
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 15
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    Gelsenkirchen : Ed. Archaea | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2019-04-01
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 16
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    Berlin : VSA-Verl. | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 17
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    Milan : Edizioni Ambiente | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 18
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 19
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 20
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 21
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 22
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 23
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    München : Beck | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: bookpart , doc-type:bookPart
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  • 24
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    München : Beck | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 25
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 26
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2014-08-15
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 27
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 28
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 29
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 30
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 31
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 32
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 33
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 34
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 35
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 36
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 37
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 38
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 39
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 40
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 41
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    München : Beck | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 42
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 43
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 44
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    Stuttgart : Diakonisches Werk der EKD | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: bookpart , doc-type:bookPart
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  • 45
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    München : Beck | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 46
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 47
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 48
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 49
    Publication Date: 2019-04-01
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: report , doc-type:report
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  • 50
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 51
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2014-08-15
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: Italian
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  • 52
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    Berlin : Mensch- & Buch-Verl. | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2016-04-28
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 53
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: report , doc-type:report
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  • 54
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Description: Von einer zukunftsfähigen Globalisierung kann nur die Rede sein, wenn der grenzen-lose Wirtschaftsprozess weder die begrenzte Elastizität der Biosphäre überfordert noch das Verlangen nach mehr Gerechtigkeit in der Welt frustriert. Was aber kann ökologische Gerechtigkeit heissen? Im allgemeinen kann Gerechtigkeit drei unterschiedliche Bedeutungen annehmen: Gerechtigkeit-als-Fairness, Gerechtigkeit-als-Gleichverteilung und Gerechtigkeit-als-Menschenwürde. In der ersten Bedeutung geht es um ein für alle Beteiligten fair organisiertes Verfahren, um zur Allokation von Vorteilen und Nachteilen zu kommen; Gerechtigkeit ist hier prozedural gedacht. In der zweiten Bedeutung geht es um die proportional angemessene Verteilung von Gütern/Rechten zwischen Personen und Gruppen; Gerechtigkeit ist hier relational gedacht. In der dritten Bedeutung geht es indessen um ein Mindestmass an Gütern/Rechten für eine würdige Existenz; Gerechtigkeit ist hier absolut gedacht. Dieses Papier entwickelt im Sinne der dritten Bedeutung das Thema der internationalen Umweltgerechtigkeit als Frage der Menschenrechte. Es skizziert zunächst sechs typische Situationen, in denen Muster der Ressourcennutzung mit Subsistenzrechten in Widerstreit geraten: Konflikte entstehen aufgrund des Abbaus von Rohstoffen, des Umbaus von Ökosystemen, der Reprogrammierung von Organismen, der Destabilisierung durch Klimawandel, der Verschmutzung von Lebensraum in Städten sowie aufgrund der Entwicklung von Ressourcenpreisen. Sodann führt das Papier in die Menschenrechtsdebatte ein und verortet die Achtung von Subsistenzrechten als Teil der wirtschaftlichen, sozialen und kulturellen Menschenrechte. Schließlich werden Orientierungspunkte für eine menschenrechtsorientierte Umweltpolitik formuliert, die darauf abzielen, das Bürgerrecht für alle Weltbewohner auch angesichts der Endlichkeit der Biosphäre zu garantieren. Denn weder staatliche Machtspiele noch wirtschaftlicher Wettkampf, sondern die Verwirklichung der Menschenrechte sollte - neben der Achtsamkeit gegenüber der Biosphäre - der aufziehenden Weltgesellschaft ihr Gesicht geben.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 55
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Description: In diesem Papier wird der Frage nachgegangen, ob der Wertekontext der Nachhaltigkeit mit den Mitteln des Eventmarketing erlebnisreicher vermittelt werden kann. Um diese Frage zu reflektieren, werden zunächst einige Theorie geleitete Überlegungen angestellt, um Nachhaltigkeit und Eventmarketing in ihren jeweiligen kulturellen Kontexten besser zu verstehen. Die Entwicklung zu einer "Erlebnisgesellschaft" verändert auch die Kommunikationsformen der Unternehmen. Imagepflege, die Werbung für Produkte und die Präsentation von Personen finden zunehmend im Rahmen von Inszenierungen und Veranstaltungen mit Erlebnischarakter statt, die als Event bezeichnet werden. Hierbei ist zu erkennen, dass dieser kommunikative Erlebnisrahmen von Steigerungsspielen geprägt ist, die die Inhalte der Kommunikation in den Hintergrund treten lassen. Von daher wird abschließend auf die Risiken hingewiesen, die eine unreflektierte Adaption der Events für den Nachhaltigkeitsdiskurs mit sich bringen könnte.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Description: This study focuses on the economic, market-related context of consumption patterns and incorporates the regulatory settings and values. The aim is to systemise the influences on sustainable consumption patterns. Special attention is drawn to the question how existing niche markets could be extended to mass markets. This question is deepened by case studies on the green textile and the green power markets. The results emphasise the different key factors which influence the successful pathways for an extended green market volume. Looking at the case of the green power market it can be seen how important it is to create an economic and institutional context for adoption. Looking at the case of green textiles the importance of new lifestyles and cultural impacts are obvious. Looking at the interfaces between institutional settings, supply structure, societal values and consumers' decision-making, it can be seen that consumers' demands are not only a product of individual needs. Therefore sustainable consumption strategies will have to face not only the change of needs, but also the change of structures which influence individual choices.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Description: In diesem Wuppertal Paper unternehmen Claudia von Braunmühl und Uta von Winterfeld eine begriffliche Erkundung im Spannungsfeld von Nachhaltigkeit, Globalisierung und Demokratie. Sie beziehen sich vorrangig auf die Arbeiten der Enquete-Kommission des Deutschen Bundestages "Globalisierung der Weltwirtschaft" (2002) und stellen das dort verhandelte Konzept von Global Governance vor sowie seine demokratietheoretische Schwächen. Des weiteren geht es um zwei Denkrichtungen, die den Autorinnen geeignet erscheinen, der politischen Dimension und Problematik von Globalisierungsprozessen gerecht zu werden. In einem Abschnitt über "Nachhaltiges Regieren?" skizzieren sie, entlang welcher Rationalitätsmuster die Demokratiedefizite in Verbindung mit Globalisierung und Nachhaltigkeit verlaufen und verknüpfen diese Überlegungen mit der Debatte, die derzeit zum Themenkomplex "globale öffentliche Güter" geführt wird.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Description: Globalization has a credible future only if the borderless economy does not overstretch the resilience of the biosphere and frustrate demands for greater justice in the world. But what means environmental justice in a transnational context? In general, justice may have three different senses: justice as fairness, justice as equitable distribution, and justice as human dignity. In the first it is a question of organized procedures for the allocation of advantages and disadvantages that are fair to everyone involved; this is the procedural conception of justice. In the second it is a question of proportionate distribution of goods and rights among individuals or groups; this is the relational conception of justice. And in the third it is a question of the minimum goods or rights necessary for a dignified existence; this is the absolute or substantive conception of justice. This paper develops the theme of international environmental justice in the third sense, as a human rights issue. First, it outlines six typical situations in which patterns of resource use come into conflict with subsistence rights: namely, extraction of raw materials, alteration of ecosystems, reprogramming of organisms, destabilization as a result of climate change, pollution of urban living space, and effects of resource prices. It then introduces the debate on human rights and locates respect for subsistence rights as a component of economic, social and cultural human rights. Finally, it offers some markers for an environmental policy geared to human rights, the aim of which is to guarantee civil rights for all in a world with a finite biosphere. Neither power play between states nor economic competition, but the realization of human rights and respect for the biosphere, should be the defining feature of the emergent world society.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publication Date: 2022-02-18
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 61
    Publication Date: 2003-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brivanlou, Ali H -- Gage, Fred H -- Jaenisch, Rudolf -- Jessell, Thomas -- Melton, Douglas -- Rossant, Janet -- New York, N.Y. -- Science. 2003 May 9;300(5621):913-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rockefeller University, New York, NY 10021, USA. brvnlou@rockefeller.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12738841" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Specimen Banks ; Cell Culture Techniques/methods ; Cell Differentiation ; Cell Division ; *Cell Line ; Culture Media ; Culture Media, Conditioned ; Databases, Factual ; *Embryo Research ; Embryo, Mammalian/*cytology ; Humans ; Quality Control ; Registries ; Research/standards ; Signal Transduction ; Stem Cell Transplantation ; *Stem Cells/cytology/physiology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 62
    Publication Date: 2003-05-31
    Description: Patients with cerebellar damage are known to exhibit deficits in the temporal control of movements. We report that these deficits are restricted to discontinuous movements. Cerebellar patients exhibited no deficit in temporal variability when producing continuous, rhythmic movements. We hypothesize that the temporal properties of continuous movements are emergent and reflect the operation of other control parameters not associated with the cerebellum. In contrast, discontinuous movements require an explicit representation of the temporal goal, a function of the cerebellum. The requirement for explicit temporal representation provides a parsimonious account of cerebellar involvement in a range of tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spencer, Rebecca M C -- Zelaznik, Howard N -- Diedrichsen, Jorn -- Ivry, Richard B -- NS17778/NS/NINDS NIH HHS/ -- NS30256/NS/NINDS NIH HHS/ -- NS40813/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 May 30;300(5624):1437-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA 94720, USA. rspencer@socrates.berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12775842" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; Cerebellar Diseases/*physiopathology ; Cerebellum/physiology/*physiopathology ; Female ; Humans ; Male ; Middle Aged ; *Motor Activity ; Movement ; *Psychomotor Performance ; Spinocerebellar Degenerations/*physiopathology ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):849-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574616" target="_blank"〉PubMed〈/a〉
    Keywords: Agouti-Related Protein ; Animals ; Anti-Obesity Agents/adverse effects/pharmacology/*therapeutic use ; Appetite/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Ciliary Neurotrophic Factor/therapeutic use ; Clinical Trials as Topic ; Cyclobutanes/adverse effects/therapeutic use ; Energy Intake ; Ghrelin ; Humans ; Hunger/drug effects ; Intercellular Signaling Peptides and Proteins ; Lactones/adverse effects/therapeutic use ; Leptin/metabolism/therapeutic use ; Mice ; Nerve Tissue Proteins/adverse effects/therapeutic use ; Neurons/metabolism ; Neuropeptide Y/metabolism/pharmacology ; Obesity/*drug therapy/metabolism ; Peptide Fragments ; Peptide Hormones/metabolism/pharmacology ; Peptide YY/metabolism/pharmacology ; Phentermine/adverse effects/therapeutic use ; Proteins/metabolism ; Receptors, Corticotropin/metabolism ; Receptors, Melanocortin ; Weight Loss ; alpha-MSH/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 64
    Publication Date: 2003-10-04
    Description: Analysis of the human and mouse genomes identified an abundance of conserved non-genic sequences (CNGs). The significance and evolutionary depth of their conservation remain unanswered. We have quantified levels and patterns of conservation of 191 CNGs of human chromosome 21 in 14 mammalian species. We found that CNGs are significantly more conserved than protein-coding genes and noncoding RNAS (ncRNAs) within the mammalian class from primates to monotremes to marsupials. The pattern of substitutions in CNGs differed from that seen in protein-coding and ncRNA genes and resembled that of protein-binding regions. About 0.3% to 1% of the human genome corresponds to a previously unknown class of extremely constrained CNGs shared among mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dermitzakis, Emmanouil T -- Reymond, Alexandre -- Scamuffa, Nathalie -- Ucla, Catherine -- Kirkness, Ewen -- Rossier, Colette -- Antonarakis, Stylianos E -- New York, N.Y. -- Science. 2003 Nov 7;302(5647):1033-5. Epub 2003 Oct 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Medical Genetics and National Center of Competence in Research (NCCR) Frontiers in Genetics, University of Geneva Medical School and University Hospitals, 1211 Geneva, Switzerland. Emmanouil.Dermitzakis@medecine.unige.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14526086" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosomes, Human, Pair 21/*genetics ; Chromosomes, Mammalian/*genetics ; *Conserved Sequence ; DNA, Intergenic/*genetics ; Discriminant Analysis ; *Evolution, Molecular ; Female ; Genetic Code ; Genome ; Humans ; Male ; Mammals/*genetics ; Molecular Sequence Data ; Polymerase Chain Reaction ; Proteins/genetics ; RNA, Untranslated/genetics ; Selection, Genetic ; Sequence Alignment ; Species Specificity ; Time ; Transcription, Genetic
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-07-26
    Description: Despite recent genetic evidence and the promise of individualized medicine, there is a continuing interest in using self-identified categories of race and ethnicity as variables in scientific and medical research. The U.S. Food and Drug Administration recently proposed a standardized approach for the collection of race and ethnicity data in clinical trials. We believe that this move fails to acknowledge new scientific data and recommend that relevant data from individuals be collected and used rather than broad group statistics. We also encourage that increased funding be committed to this important issue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haga, Susanne B -- Venter, J Craig -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):466.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Advancement of Genomics, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12881555" target="_blank"〉PubMed〈/a〉
    Keywords: *Clinical Trials as Topic ; *Continental Population Groups/genetics ; *Ethnic Groups/genetics ; Gene Frequency ; Genetic Variation ; Guidelines as Topic ; Humans ; Pharmacogenetics ; United States ; *United States Food and Drug Administration
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  • 66
    Publication Date: 2003-04-19
    Description: Soluble oligomers are common to most amyloids and may represent the primary toxic species of amyloids, like the Abeta peptide in Alzheimer's disease (AD). Here we show that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomers regardless of sequence. The in vitro toxicity of soluble oligomers is inhibited by oligomer-specific antibody. Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kayed, Rakez -- Head, Elizabeth -- Thompson, Jennifer L -- McIntire, Theresa M -- Milton, Saskia C -- Cotman, Carl W -- Glabe, Charles G -- AG00538/AG/NIA NIH HHS/ -- AG16573/AG/NIA NIH HHS/ -- NS31230/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 18;300(5618):486-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12702875" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism/pathology ; Amyloid/chemistry/toxicity ; Amyloid beta-Peptides/analysis/*chemistry/immunology/toxicity ; Animals ; Antibodies/immunology ; Antibody Specificity ; Biopolymers/analysis/chemistry/toxicity ; Brain/pathology ; Brain Chemistry ; Cell Survival ; Humans ; Microscopy, Confocal ; Microscopy, Electron ; Molecular Mimicry ; Neurofibrillary Tangles/chemistry ; Peptide Fragments/chemistry/immunology ; Protein Conformation ; Rabbits ; Solubility ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 67
    Publication Date: 2003-08-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, Stephen S -- New York, N.Y. -- Science. 2003 Aug 29;301(5637):1165.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12947168" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Caloric Restriction ; *Flavonoids ; *Gene Expression Regulation ; Histone Deacetylases/*genetics/metabolism ; Humans ; *Longevity ; Phenols/metabolism ; Polymers/metabolism ; Polyphenols ; Saccharomyces cerevisiae/genetics/physiology ; Silent Information Regulator Proteins, Saccharomyces ; cerevisiae/*genetics/metabolism ; Sirtuin 1 ; Sirtuin 2 ; Sirtuins/*genetics/metabolism ; Stilbenes/*metabolism ; Vitis/chemistry ; *Wine
    Print ISSN: 0036-8075
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  • 68
    Publication Date: 2003-07-19
    Description: The principles underlying human hemispheric specialization are poorly understood. We used functional magnetic resonance imaging of letter and visuospatial decision tasks with identical word stimuli to address two unresolved problems. First, hemispheric specialization depended on the nature of the task rather than on the nature of the stimulus. Second, analysis of frontal candidate regions for cognitive control showed increased coupling between left anterior cingulate cortex (ACC) and left inferior frontal gyrus during letter decisions, whereas right ACC showed enhanced coupling with right parietal areas during visuospatial decisions. Cognitive control is thus localized in the same hemisphere as task execution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephan, Klaas E -- Marshall, John C -- Friston, Karl J -- Rowe, James B -- Ritzl, Afra -- Zilles, Karl -- Fink, Gereon R -- 077029/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2003 Jul 18;301(5631):384-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medicine (IME), Research Centre Julich, 52425 Julich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12869765" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/*physiology ; Brain Mapping ; *Cognition ; Functional Laterality ; Gyrus Cinguli/physiology ; Humans ; *Language ; Magnetic Resonance Imaging ; Male ; Parietal Lobe/physiology ; Prefrontal Cortex/physiology ; Space Perception ; Visual Perception
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, Ingrid -- New York, N.Y. -- Science. 2003 Jan 24;299(5606):497.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12543950" target="_blank"〉PubMed〈/a〉
    Keywords: Amyotrophic Lateral Sclerosis/physiopathology/*rehabilitation ; Brain/*physiology ; *Communication Aids for Disabled ; *Computer Systems ; Electroencephalography ; Humans ; Software ; *User-Computer Interface
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-11-01
    Description: Although neurodegenerative diseases such as Alzheimer's disease are not classically considered mediated by inflammation or the immune system, in some instances the immune system may play an important role in the degenerative process. Furthermore, it has become clear that the immune system itself may have beneficial effects in nervous system diseases considered neurodegenerative. Immunotherapeutic approaches designed to induce a humoral immune response have recently been developed for the treatment of Alzheimer's disease. These studies have led to human trials that resulted in both beneficial and adverse effects. In animal models, it has also been shown that immunotherapy designed to induce a cellular immune response may be of benefit in central nervous system injury, although T cells may have either a beneficial or detrimental effect depending on the type of T cell response induced. These areas provide a new avenue for exploring immune system-based therapy of neurodegenerative diseases and will be discussed here with a primary focus on Alzheimer's disease. We will also discuss how these approaches affect microglia activation, which plays a key role in therapy of such diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monsonego, Alon -- Weiner, Howard L -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):834-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. amonsonego@rics.bwh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593170" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*therapy ; Alzheimer Vaccines/adverse effects/*therapeutic use ; Amyloid beta-Peptides/*immunology/metabolism ; Animals ; Antibody Formation ; Antigen-Presenting Cells/immunology ; Central Nervous System/immunology ; Clinical Trials as Topic ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Immunization ; *Immunotherapy/adverse effects ; Lymphocyte Activation ; Microglia/immunology ; Nitric Oxide/metabolism ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
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  • 71
    Publication Date: 2003-03-01
    Description: Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hasty, Paul -- Campisi, Judith -- Hoeijmakers, Jan -- van Steeg, Harry -- Vijg, Jan -- AG17242/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1355-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78245, USA. hastye@uthscsa.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610296" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging/genetics ; Aging, Premature/*genetics ; Animals ; Apoptosis ; Cell Aging ; *DNA Damage ; DNA Helicases/genetics/metabolism ; *DNA Repair/genetics ; Exodeoxyribonucleases ; *Genome ; Genome, Human ; Humans ; Longevity/genetics ; Mice ; Mutation ; Reactive Oxygen Species/metabolism ; RecQ Helicases ; Syndrome ; Telomere/physiology ; Transcription, Genetic
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  • 72
    Publication Date: 2003-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butte, Nancy F -- Ellis, Kenneth J -- New York, N.Y. -- Science. 2003 Aug 1;301(5633):598; author reply 598.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA. nbutte@bcm.tmc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12893926" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Body Mass Index ; Child ; Diet ; *Energy Intake ; *Energy Metabolism ; *Exercise ; Feeding Behavior ; Humans ; Life Style ; *Obesity/epidemiology/prevention & control ; United States/epidemiology ; *Weight Gain
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-05-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2003 May 16;300(5622):1053.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12750481" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*economics/epidemiology/prevention & ; control/transmission ; Africa/epidemiology ; Disease Outbreaks/economics ; Financing, Government ; Health Care Costs ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; South Africa/epidemiology ; United States
    Print ISSN: 0036-8075
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  • 74
    Publication Date: 2003-07-12
    Description: Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIbalpha-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dumas, John J -- Kumar, Ravindra -- Seehra, Jasbir -- Somers, William S -- Mosyak, Lidia -- New York, N.Y. -- Science. 2003 Jul 11;301(5630):222-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical and Screening Sciences, Wyeth, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12855811" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Blood Platelets/chemistry/physiology ; Crystallization ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Platelet Adhesiveness ; *Platelet Aggregation ; Platelet Glycoprotein GPIb-IX Complex/*chemistry/*metabolism ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thrombin/*chemistry/*metabolism
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-11-01
    Description: Parkinson's disease (PD) is a complex disorder with many different causes, yet they may intersect in common pathways, raising the possibility that neuroprotective agents may have broad applicability in the treatment of PD. Current evidence suggests that mitochondrial complex I inhibition may be the central cause of sporadic PD and that derangements in complex I cause alpha-synuclein aggregation, which contributes to the demise of dopamine neurons. Accumulation and aggregation of alpha-synuclein may further contribute to the death of dopamine neurons through impairments in protein handling and detoxification. Dysfunction of parkin (a ubiquitin E3 ligase) and DJ-1 could contribute to these deficits. Strategies aimed at restoring complex I activity, reducing oxidative stress and alpha-synuclein aggregation, and enhancing protein degradation may hold particular promise as powerful neuroprotective agents in the treatment of PD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dawson, Ted M -- Dawson, Valina L -- NS38377/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):819-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. tdawson@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593166" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Brain/*metabolism/pathology ; Cysteine Endopeptidases/metabolism ; Dopamine/metabolism ; Electron Transport Complex I/antagonists & inhibitors/genetics/*metabolism ; Humans ; Mitochondria/enzymology ; Multienzyme Complexes/metabolism ; Mutation ; Nerve Degeneration ; Nerve Tissue Proteins/chemistry/genetics/metabolism ; Neurons/*metabolism/pathology ; Oxidative Stress ; Parkinson Disease/*etiology/genetics/metabolism/pathology ; Parkinsonian Disorders/genetics/metabolism/pathology ; Proteasome Endopeptidase Complex ; Synucleins ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics/metabolism ; alpha-Synuclein
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-08-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowers, Evelyn J -- New York, N.Y. -- Science. 2003 Aug 8;301(5634):764-5; author reply 764-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12907779" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosomes, Human/genetics ; Chromosomes, Human, Pair 2/genetics ; Chromosomes, Mammalian/*genetics ; Evolution, Molecular ; Genetics, Population ; Hominidae/*genetics ; Humans ; Pan troglodytes/*genetics ; *Recombination, Genetic ; *Selection, Genetic ; Translocation, Genetic
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  • 77
    Publication Date: 2003-04-12
    Description: Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin ligase, and both interact with p300-CREB-binding protein transcriptional coactivator proteins. p53 is stabilized by the binding of p300 to the oncoprotein E1A, suggesting that p300 regulates p53 degradation. Purified p300 exhibited intrinsic ubiquitin ligase activity that was inhibited by E1A. In vitro, p300 with MDM2 catalyzed p53 polyubiquitination, whereas MDM2 catalyzed p53 monoubiquitination. E1A expression caused a decrease in polyubiquitinated but not monoubiquitinated p53 in cells. Thus, generation of the polyubiquitinated forms of p53 that are targeted for proteasome degradation requires the intrinsic ubiquitin ligase activities of MDM2 and p300.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grossman, Steven R -- Deato, Maria E -- Brignone, Chrystelle -- Chan, Ho Man -- Kung, Andrew L -- Tagami, Hideaki -- Nakatani, Yoshihiro -- Livingston, David M -- CA15751/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):342-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690203" target="_blank"〉PubMed〈/a〉
    Keywords: Adenovirus E1A Proteins/metabolism ; Animals ; Catalysis ; Cells, Cultured ; E1A-Associated p300 Protein ; Embryo, Mammalian ; Fibroblasts/metabolism ; Humans ; Ligases/antagonists & inhibitors/metabolism ; Mice ; Nuclear Proteins/antagonists & inhibitors/*metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-mdm2 ; Recombinant Fusion Proteins/metabolism ; Recombinant Proteins/metabolism ; Trans-Activators/antagonists & inhibitors/*metabolism ; Transfection ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/*metabolism ; Ubiquitin-Protein Ligases ; Ubiquitins/*metabolism
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roelofs, Cora R -- Ellenbecker, Michael J -- New York, N.Y. -- Science. 2003 May 30;300(5624):1372.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12775824" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; Environmental Health ; *Government Regulation ; *Health ; Humans ; Safety ; United States ; *United States Occupational Safety and Health Administration ; *Value of Life
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  • 79
    Publication Date: 2003-03-29
    Description: Elaborate one-dimensional photonic crystals are constructed from a variety of organic and biopolymers, which can be dissolved or melted, by templating the solution-cast or injection-molded materials in porous silicon or porous silicon dioxide multilayer (rugate dielectric mirror) structures. After the removal of the template by chemical dissolution, the polymer castings replicate the photonic features and the nanostructure of the master. We demonstrate that these castings can be used as vapor sensors, as deformable and tunable optical filters, and as self-reporting, bioresorbable materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Yang Yang -- Cunin, Frederique -- Link, Jamie R -- Gao, Ting -- Betts, Ronald E -- Reiver, Sarah H -- Chin, Vicki -- Bhatia, Sangeeta N -- Sailor, Michael J -- New York, N.Y. -- Science. 2003 Mar 28;299(5615):2045-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Department 0358, La Jolla, CA 92093-0358, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12663921" target="_blank"〉PubMed〈/a〉
    Keywords: *Biocompatible Materials ; Caffeine ; *Drug Delivery Systems ; Ethanol ; Humans ; Hydrogen-Ion Concentration ; Hydrolysis ; Light ; *Nanotechnology ; Optics and Photonics ; Oxidation-Reduction ; Polyesters/chemistry ; Polyethylene/chemistry ; *Polymers ; Polystyrenes/chemistry ; Porosity ; *Silicon/chemistry ; Silicon Dioxide/chemistry ; Spectrum Analysis ; Volatilization
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  • 80
    Publication Date: 2003-04-26
    Description: The active-site cysteine of peroxiredoxins is selectively oxidized to cysteine sulfinic acid during catalysis, which leads to inactivation of peroxidase activity. This oxidation was thought to be irreversible. However, by metabolic labeling of mammalian cells with 35S, we show that the sulfinic form of peroxiredoxin I, produced during the exposure of cells to H2O2, is rapidly reduced to the catalytically active thiol form. The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woo, Hyun Ae -- Chae, Ho Zoon -- Hwang, Sung Chul -- Yang, Kap-Seok -- Kang, Sang Won -- Kim, Kanghwa -- Rhee, Sue Goo -- New York, N.Y. -- Science. 2003 Apr 25;300(5619):653-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12714748" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catalysis ; Cell Line ; Cycloheximide/pharmacology ; Cysteine/*analogs & derivatives/*metabolism ; Dimerization ; HeLa Cells ; Humans ; Hydrogen Peroxide/*metabolism ; Methionine/metabolism ; Mice ; Neurotransmitter Agents ; Oxidation-Reduction ; Peroxidases/chemistry/*metabolism ; Peroxiredoxins ; Protein Synthesis Inhibitors/pharmacology ; Spectrometry, Mass, Electrospray Ionization ; Sulfhydryl Compounds/metabolism ; Sulfinic Acids/metabolism ; Tumor Cells, Cultured
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  • 81
    Publication Date: 2003-04-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eden, Amir -- Gaudet, Francois -- Waghmare, Alpana -- Jaenisch, Rudolf -- CA87869/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 18;300(5618):455.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12702868" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosomes, Mammalian/*genetics/physiology ; DNA (Cytosine-5-)-Methyltransferase/genetics/metabolism ; *DNA Methylation ; Fibroblasts/metabolism ; Genes, Neurofibromatosis 1 ; Genes, p53 ; Humans ; *Loss of Heterozygosity ; Mice ; Mutation ; Neoplasms/genetics ; Recombination, Genetic ; Sarcoma/*genetics ; Soft Tissue Neoplasms/*genetics
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  • 82
    Publication Date: 2003-05-06
    Description: We have used adenosine diphosphate analogs containing electron paramagnetic resonance (EPR) spin moieties and EPR spectroscopy to show that the nucleotide-binding site of kinesin-family motors closes when the motor.diphosphate complex binds to microtubules. Structural analyses demonstrate that a domain movement in the switch 1 region at the nucleotide site, homologous to domain movements in the switch 1 region in the G proteins [heterotrimeric guanine nucleotide-binding proteins], explains the EPR data. The switch movement primes the motor both for the free energy-yielding nucleotide hydrolysis reaction and for subsequent conformational changes that are crucial for the generation of force and directed motion along the microtubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naber, Nariman -- Minehardt, Todd J -- Rice, Sarah -- Chen, Xiaoru -- Grammer, Jean -- Matuska, Marija -- Vale, Ronald D -- Kollman, Peter A -- Car, Roberto -- Yount, Ralph G -- Cooke, Roger -- Pate, Edward -- AR39643/AR/NIAMS NIH HHS/ -- AR42895/AR/NIAMS NIH HHS/ -- DK05915/DK/NIDDK NIH HHS/ -- GM29072/GM/NIGMS NIH HHS/ -- RR1081/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2003 May 2;300(5620):798-801.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of California, San Francisco, CA 94143, USA. naber@itsa.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12730601" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/*metabolism ; Adenosine Diphosphate/analogs & derivatives/metabolism ; Adenosine Triphosphate/analogs & derivatives/metabolism ; Animals ; Binding Sites ; Computer Simulation ; Crystallography, X-Ray ; *Drosophila Proteins ; Drosophila melanogaster ; Electron Spin Resonance Spectroscopy ; Humans ; Hydrogen Bonding ; Hydrolysis ; Kinesin/*chemistry/*metabolism ; Microtubules/*metabolism ; Models, Molecular ; Molecular Motor Proteins/*chemistry/*metabolism ; Molecular Probes/metabolism ; Protein Conformation ; Spin Labels
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Webster, Paul -- New York, N.Y. -- Science. 2003 Mar 14;299(5613):1642.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12637710" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arctic Regions ; Canada ; *Ecosystem ; Environmental Exposure/*adverse effects ; Environmental Pollutants/*analysis ; Female ; Humans ; Infant ; Infection/epidemiology/etiology ; *Inuits ; Memory ; Risk Factors
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-10-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hedrick, Philip W -- New York, N.Y. -- Science. 2003 Oct 3;302(5642):57.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14526061" target="_blank"〉PubMed〈/a〉
    Keywords: Ethnic Groups/*genetics ; Female ; Genetic Variation ; Genotype ; Haplotypes ; *Heterozygote ; Humans ; Kuru/*genetics ; Male ; Middle Aged ; Papua New Guinea ; PrPC Proteins/*genetics ; *Selection, Genetic
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-08-09
    Description: Large-scale genome sequencing is providing a comprehensive view of the complex evolutionary forces that have shaped the structure of eukaryotic chromosomes. Comparative sequence analyses reveal patterns of apparently random rearrangement interspersed with regions of extraordinarily rapid, localized genome evolution. Numerous subtle rearrangements near centromeres, telomeres, duplications, and interspersed repeats suggest hotspots for eukaryotic chromosome evolution. This localized chromosomal instability may play a role in rapidly evolving lineage-specific gene families and in fostering large-scale changes in gene order. Computational algorithms that take into account these dynamic forces along with traditional models of chromosomal rearrangement show promise for reconstructing the natural history of eukaryotic chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eichler, Evan E -- Sankoff, David -- GM58815/GM/NIGMS NIH HHS/ -- HD43569/HD/NICHD NIH HHS/ -- HG02385/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2003 Aug 8;301(5634):793-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Center for Human Genetics and Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA. eee@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12907789" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Centromere/physiology ; Chromosome Aberrations ; *Chromosomes/genetics/physiology/ultrastructure ; Computational Biology ; DNA Transposable Elements ; Eukaryotic Cells/physiology/*ultrastructure ; Gene Duplication ; Genome ; Humans ; Recombination, Genetic ; Synteny ; Telomere/physiology
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-03-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wuethrich, Bernice -- New York, N.Y. -- Science. 2003 Mar 7;299(5612):1504.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12624244" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Birds/virology ; Chickens/virology ; Child ; China/epidemiology ; Hong Kong/epidemiology ; Humans ; Influenza A virus/genetics/immunology/*pathogenicity ; Influenza Vaccines ; Influenza in Birds/epidemiology/*virology ; Influenza, Human/*virology ; Male ; Virulence ; World Health Organization
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  • 87
    Publication Date: 2003-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wozny, Christian -- Kivi, Anatol -- Lehmann, Thomas-Nicolas -- Dehnicke, Christoph -- Heinemann, Uwe -- Behr, Joachim -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):463; author reply 463.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuroscience Research Center, at the Charite, Humboldt University of Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12881553" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Electroencephalography ; Epilepsy, Temporal Lobe/pathology/*physiopathology ; Excitatory Amino Acid Antagonists ; Hippocampus/pathology/*physiopathology ; Humans ; In Vitro Techniques ; Neurons/physiology ; Neurons, Afferent/physiology ; Receptors, GABA-A/metabolism ; Receptors, Glutamate/metabolism ; Synaptic Transmission ; Temporal Lobe/physiopathology
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  • 88
    Publication Date: 2003-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Edwards, E Stephen -- Green, Nancy -- Henry, Carol J -- Landrigan, Philip J -- Swartz, Daniel -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):781.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593148" target="_blank"〉PubMed〈/a〉
    Keywords: *Child ; *Child Development ; Costs and Cost Analysis ; *Disease ; *Epidemiologic Studies ; *Health ; Humans ; Social Environment ; United States
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Branca, Malorye -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):238.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690165" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/*classification/*genetics/therapy ; Clinical Trials as Topic ; Female ; *Gene Expression Profiling ; Humans ; Netherlands ; *Oligonucleotide Array Sequence Analysis ; Prognosis
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, Laura -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):808-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593163" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; Brain/pathology/physiopathology ; Child ; Clinical Trials as Topic ; Humans ; *Manuals as Topic ; Mental Disorders/*classification/*diagnosis/epidemiology/genetics ; *Mental Health ; Personality Disorders/classification/diagnosis/genetics ; Psychotropic Drugs/pharmacology/therapeutic use ; Risk Factors ; Social Environment ; Terminology as Topic
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  • 91
    Publication Date: 2003-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajagopal, Jayaraj -- Anderson, William J -- Kume, Shoen -- Martinez, Olga I -- Melton, Douglas A -- New York, N.Y. -- Science. 2003 Jan 17;299(5605):363.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12532008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/immunology ; Apoptosis ; Cell Differentiation ; Cell Line ; Embryo, Mammalian/*cytology ; Humans ; Insulin/*analysis/genetics/immunology/*metabolism ; Islets of Langerhans/*cytology/metabolism ; Mice ; Microscopy, Confocal ; RNA, Messenger/genetics/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Stem Cells/*cytology/metabolism
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  • 92
    Publication Date: 2003-04-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Sandre-Giovannoli, Annachiara -- Bernard, Rafaelle -- Cau, Pierre -- Navarro, Claire -- Amiel, Jeanne -- Boccaccio, Irene -- Lyonnet, Stanislas -- Stewart, Colin L -- Munnich, Arnold -- Le Merrer, Martine -- Levy, Nicolas -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Inserm U491: Genetique Medicale et Developpement, Faculte de Medecine Timone, Marseille, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12702809" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Cell Nucleus/ultrastructure ; Child ; Exons ; Female ; Humans ; Lamin Type A/analysis/*chemistry/*genetics ; Lymphocytes/chemistry/ultrastructure ; Mutation ; Polymorphism, Genetic ; Progeria/blood/*genetics ; RNA Splicing ; RNA, Messenger/genetics ; Sequence Deletion ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-12-13
    Description: Global food security will remain a worldwide concern for the next 50 years and beyond. Recently, crop yield has fallen in many areas because of declining investments in research and infrastructure, as well as increasing water scarcity. Climate change and HIV/AIDS are also crucial factors affecting food security in many regions. Although agroecological approaches offer some promise for improving yields, food security in developing countries could be substantially improved by increased investment and policy reforms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosegrant, Mark W -- Cline, Sarah A -- New York, N.Y. -- Science. 2003 Dec 12;302(5652):1917-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉International Food Policy Research Institute, 2033 K Street, N.W., Washington, DC 20006, USA. m.rosegrant@cgiar.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14671289" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology ; *Agriculture ; Biotechnology ; Climate ; Conservation of Natural Resources ; Developing Countries ; Ecosystem ; Education ; *Food ; *Food Supply ; Global Health ; Humans ; Poverty ; *Public Policy ; Research ; Rural Population ; Water Supply
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-04-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, Laura -- New York, N.Y. -- Science. 2003 Apr 25;300(5619):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12714719" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/*physiology ; *Attention ; Cerebral Cortex/physiology ; Emotions ; *Facial Expression ; *Fear ; Frontal Lobe/physiology ; Humans ; Magnetic Resonance Imaging ; Parietal Lobe/physiology ; Visual Cortex/physiology ; Visual Pathways
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-06-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casassus, Barbara -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2019.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12829758" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Serodiagnosis ; Blood/*virology ; Blood Donors ; Blood Transfusion ; Blood-Borne Pathogens ; Creutzfeldt-Jakob Syndrome/transmission ; Drug Contamination ; France ; *Hiv ; HIV Infections/*transmission ; Human Growth Hormone ; Humans ; *Jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-01-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyman, Edwin S -- New York, N.Y. -- Science. 2003 Jan 10;299(5604):201-3; author reply 201-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12523360" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Neoplasms, Radiation-Induced/epidemiology/etiology ; Nuclear Energy ; Nuclear Reactors ; *Power Plants ; Radioactive Hazard Release ; *Safety ; Security Measures ; *Terrorism ; Thyroid Neoplasms/epidemiology/etiology ; Ukraine/epidemiology ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nestle, Marion -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):781.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574583" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; *Diet ; *Food Industry ; Humans ; Marketing ; *Nutrition Policy ; Nutritional Physiological Phenomena ; *Obesity/epidemiology/prevention & control ; Politics ; United States ; *United States Department of Agriculture
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-10-25
    Description: Noninvasive molecular-imaging technologies are providing researchers with exciting new opportunities to study small-animal models of human disease. With continued improvements in instrumentation, identification of better imaging targets by genome-based approaches, and design of better imaging probes by innovative chemistry, these technologies promise to play increasingly important roles in disease diagnosis and therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herschman, Harvey R -- P50 CA88306/CA/NCI NIH HHS/ -- R01 CA84572/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 24;302(5645):605-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, David Geffen School of Medicine at the University of California, Los Angeles, 341 Boyer Hall, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA. hherschman@mednet.ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14576425" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Diagnostic Imaging/instrumentation/methods/trends ; *Disease Models, Animal ; Gene Expression ; Gene Expression Profiling ; Genes, Reporter ; Genomics ; Humans ; *Molecular Probe Techniques/instrumentation/trends ; Tomography, Emission-Computed ; Tomography, Emission-Computed, Single-Photon
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 2003-06-14
    Description: In eukaryotes, the combinatorial association of sequence-specific DNA binding proteins is essential for transcription. We have used protein arrays to test 492 pairings of a nearly complete set of coiled-coil strands from human basic-region leucine zipper (bZIP) transcription factors. We find considerable partnering selectivity despite the bZIPs' homologous sequences. The interaction data are of high quality, as assessed by their reproducibility, reciprocity, and agreement with previous observations. Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newman, John R S -- Keating, Amy E -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2097-101. Epub 2003 Jun 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12805554" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Basic-Leucine Zipper Transcription Factors ; Chromatography, High Pressure Liquid ; Circadian Rhythm ; Circular Dichroism ; Cyclic AMP Response Element-Binding Protein/chemistry/metabolism ; DNA-Binding Proteins/chemistry/isolation & purification/*metabolism ; Dimerization ; G-Box Binding Factors ; Humans ; *Leucine Zippers ; Peptides/chemistry/isolation & purification/metabolism ; *Protein Array Analysis ; Protein Binding ; Protein Folding ; Protein Structure, Tertiary ; Signal Transduction ; Temperature ; Thermodynamics ; Transcription Factors/*chemistry/isolation & purification/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bray, Dennis -- New York, N.Y. -- Science. 2003 Feb 21;299(5610):1189-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK. d.bray@zoo.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12595679" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Antibody Diversity ; Escherichia coli Proteins/chemistry/genetics/metabolism ; Evolution, Molecular ; Genetic Variation ; Genomics ; Histones/chemistry/genetics/metabolism ; Humans ; Methylation ; Phenotype ; Potassium Channels/chemistry/genetics/metabolism ; Protein Conformation ; Protein Isoforms/chemistry/metabolism ; Protein Processing, Post-Translational ; Proteins/*chemistry/genetics/*metabolism ; Proteomics ; RNA Splicing ; Receptors, Cell Surface/chemistry/genetics/metabolism ; Selection, Genetic ; Troponin T/chemistry/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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