Publication Date:
2001-09-29
Description:
Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus laevis embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic vascularization in the posterior foregut leads to ectopic insulin expression and islet hyperplasia. These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lammert, E -- Cleaver, O -- Melton, D -- New York, N.Y. -- Science. 2001 Oct 19;294(5542):564-7. Epub 2001 Sep 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11577200" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aorta/cytology/*embryology/physiology
;
Basic Helix-Loop-Helix Transcription Factors
;
Cell Differentiation
;
Culture Techniques
;
*Embryonic Induction
;
Endoderm/*physiology
;
Endothelial Growth Factors/biosynthesis/genetics
;
Endothelium, Vascular/cytology/embryology/*physiology
;
Eye Proteins
;
Gene Expression Regulation, Developmental
;
Homeodomain Proteins/biosynthesis/genetics
;
Insulin/biosynthesis/genetics
;
Islets of Langerhans/blood supply/cytology/*embryology/metabolism
;
Lymphokines/biosynthesis/genetics
;
Mesoderm/physiology
;
Mice
;
Mice, Inbred ICR
;
Mice, Transgenic
;
Morphogenesis
;
Nerve Tissue Proteins/biosynthesis/genetics
;
Paired Box Transcription Factors
;
Pancreas/blood supply/cytology/*embryology
;
Repressor Proteins
;
Signal Transduction
;
Stomach/blood supply/cytology/embryology/metabolism
;
Trans-Activators/biosynthesis/genetics
;
Vascular Endothelial Growth Factor A
;
Vascular Endothelial Growth Factors
;
Xenopus laevis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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