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  • 1
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    Lamin a truncation in Hutchinson-Gilford progeria (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-04-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Sandre-Giovannoli, Annachiara -- Bernard, Rafaelle -- Cau, Pierre -- Navarro, Claire -- Amiel, Jeanne -- Boccaccio, Irene -- Lyonnet, Stanislas -- Stewart, Colin L -- Munnich, Arnold -- Le Merrer, Martine -- Levy, Nicolas -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Inserm U491: Genetique Medicale et Developpement, Faculte de Medecine Timone, Marseille, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12702809" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Cell Nucleus/ultrastructure ; Child ; Exons ; Female ; Humans ; Lamin Type A/analysis/*chemistry/*genetics ; Lymphocytes/chemistry/ultrastructure ; Mutation ; Polymorphism, Genetic ; Progeria/blood/*genetics ; RNA Splicing ; RNA, Messenger/genetics ; Sequence Deletion ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Positive selection of natural autoreactive B cells (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-03
    Description: Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayakawa, K -- Asano, M -- Shinton, S A -- Gui, M -- Allman, D -- Stewart, C L -- Silver, J -- Hardy, R R -- New York, N.Y. -- Science. 1999 Jul 2;285(5424):113-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. K_Hayakawa@fccc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10390361" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/immunology ; Animals ; Antigens, CD5/analysis ; Antigens, Thy-1/*immunology ; Autoantibodies/*biosynthesis/blood/immunology ; Autoantigens/*immunology ; B-Lymphocyte Subsets/*immunology ; Genes, Immunoglobulin ; Hybridomas ; Immunity, Innate ; Immunologic Surveillance ; Mice ; Mice, SCID ; Mice, Transgenic ; Receptors, Antigen, B-Cell/immunology ; Signal Transduction ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-06-13
    Description: Osteoclasts are multinucleated haematopoietic cells that resorb bone. Increased osteoclast activity causes osteoporosis, a disorder resulting in a low bone mass and a high risk of fractures. Increased osteoclast size and numbers are also a hallmark of other disorders, such as Paget's disease and multiple myeloma. The protein c-Fos, a component of the AP-1 transcription factor complex, is essential for osteoclast differentiation. Here we show that the Fos-related protein Fra-2 controls osteoclast survival and size. The bones of Fra-2-deficient newborn mice have giant osteoclasts, and signalling through leukaemia inhibitory factor (LIF) and its receptor is impaired. Similarly, newborn animals lacking LIF have giant osteoclasts, and we show that LIF is a direct transcriptional target of Fra-2 and c-Jun. Moreover, bones deficient in Fra-2 and LIF are hypoxic and express increased levels of hypoxia-induced factor 1alpha (HIF1alpha) and Bcl-2. Overexpression of Bcl-2 is sufficient to induce giant osteoclasts in vivo, whereas Fra-2 and LIF affect HIF1alpha through transcriptional modulation of the HIF prolyl hydroxylase PHD2. This pathway is operative in the placenta, because specific inactivation of Fra-2 in the embryo alone does not cause hypoxia or the giant osteoclast phenotype. Thus placenta-induced hypoxia during embryogenesis leads to the formation of giant osteoclasts in young pups. These findings offer potential targets for the treatment of syndromes associated with increased osteoclastogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bozec, Aline -- Bakiri, Latifa -- Hoebertz, Astrid -- Eferl, Robert -- Schilling, Arndt F -- Komnenovic, Vukoslav -- Scheuch, Harald -- Priemel, Matthias -- Stewart, Colin L -- Amling, Michael -- Wagner, Erwin F -- England -- Nature. 2008 Jul 10;454(7201):221-5. doi: 10.1038/nature07019. Epub 2008 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18548006" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Anoxia/*metabolism/pathology ; Bone and Bones/cytology/metabolism/pathology ; *Cell Size ; Cell Survival ; DNA-Binding Proteins/metabolism ; Female ; Fos-Related Antigen-2/deficiency/genetics/*metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Immediate-Early Proteins/metabolism ; Leukemia Inhibitory Factor/deficiency/genetics/*metabolism ; Leukemia Inhibitory Factor Receptor alpha Subunit/*metabolism ; Male ; Mice ; Osteoclasts/*cytology/metabolism/pathology ; Procollagen-Proline Dioxygenase ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-bcl-2 ; *Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Physical Conditions of Fast Glacier Flow: 3. Seasonally‐Evolving Ice Deformation on Store Glacier, West Greenland (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Temporal variations in ice sheet flow directly impact the internal structure within ice sheets through englacial deformation. Large‐scale changes in the vertical stratigraphy within ice sheets have been previously conducted on centennial to millennial timescales; however, intra‐annual changes in the morphology of internal layers have yet to be explored. Over a period of 2 years, we use autonomous phase‐sensitive radio‐echo sounding to track the daily displacement of internal layers on Store Glacier, West Greenland, to millimeter accuracy. At a site located ∼30 km from the calving terminus, where the ice is ∼600 m thick and flows at ∼700 m/a, we measure distinct seasonal variations in vertical velocities and vertical strain rates over a 2‐year period. Prior to the melt season (March–June), we observe increasingly nonlinear englacial deformation with negative vertical strain rates (i.e., strain thinning) in the upper half of the ice column of approximately −0.03 a−1, whereas the ice below thickens under vertical strain reaching up to +0.16 a−1. Early in the melt season (June–July), vertical thinning gradually ceases as the glacier increasingly thickens. During late summer to midwinter (August–February), vertical thickening occurs linearly throughout the entire ice column, with strain rates averaging 0.016 a−1. We show that these complex variations are unrelated to topographic setting and localized basal slip and hypothesize that this seasonality is driven by far‐field perturbations in the glacier's force balance, in this case generated by variations in basal hydrology near the glacier's terminus and propagated tens of kilometers upstream through transient basal lubrication longitudinal coupling.
    Print ISSN: 2169-9003
    Electronic ISSN: 2169-9011
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    Blurring the boundary: the nuclear envelope extends its reach (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-12-01
    Description: The past decade has seen a complete rethinking of the traditional view of the nuclear envelope as simply a passive enclosure for the chromosomes. The convergence of several lines of clinical and basic research has revealed additional roles in both signaling and mitotic progression. It is becoming apparent that the nuclear envelope defines not only nuclear organization but also that of the cytoskeleton and, in this way, integrates both nuclear and cytoplasmic architecture.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stewart, Colin L -- Roux, Kyle J -- Burke, Brian -- New York, N.Y. -- Science. 2007 Nov 30;318(5855):1408-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medical Biology, 61 Biopolis Drive, Proteos, Singapore 138668, Singapore.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18048680" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytoplasm/physiology/ultrastructure ; Cytoskeleton/parasitology/physiology/ultrastructure ; Genetic Diseases, Inborn/pathology/physiopathology ; Humans ; Lamins/genetics ; Mitosis ; Mutation ; Nuclear Envelope/*physiology/*ultrastructure ; Nuclear Lamina/physiology/ultrastructure ; Nuclear Pore/physiology/ultrastructure ; Signal Transduction ; Virus Diseases/metabolism/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    On theabc conjecture (1991)
    Springer
    Mathematische Annalen 291 (1991), S. 225-230 
    Details
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01445201
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  • 7
    Electronic Resource
    Electronic Resource
    On irregularities of distribution in shifts and dilations of integer sequences. I (1987)
    Springer
    Mathematische Annalen 276 (1987), S. 353-364 
    Details
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01450834
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  • 8
    Electronic Resource
    Electronic Resource
    Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1 (1996)
    [s.l.] : Nature Publishing Group
    Nature 379 (1996), S. 826-829 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Thy-1 gene was inactivated in 129/Sv embryonic stem cells by insertion of a neo cassette to disrupt the codon for the third amino acid of the mature protein (Fig. la). The inactivated gene was identified by Southern blotting (Fig. 16), and no Thy-1 protein could be detected in Thy-1' mice ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/379826a0
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  • 9
    Electronic Resource
    Electronic Resource
    OnS-unit equations in two unknowns (1988)
    Springer
    Inventiones mathematicae 92 (1988), S. 461-477 
    Details
    ISSN: 1432-1297
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01393743
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  • 10
    Electronic Resource
    Electronic Resource
    On the Oesterlé-Masser conjecture (1986)
    Springer
    Monatshefte für Mathematik 102 (1986), S. 251-257 
    Details
    ISSN: 1436-5081
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Letx, y andz be positive integers such thatx=y+z and ged (x,y,z)=1. We give upper and lower bounds forx in terms of the greatest squarefree divisor ofx y z.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294603
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