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  • Chemistry  (14.370)
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  • 1
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-07-20
    Beschreibung: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-06
    Beschreibung: Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonner, T -- O'Brien, S J -- Nash, W G -- Rapp, U R -- Morton, C C -- Leder, P -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):71-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691137" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/genetics ; Animals ; Chromosome Aberrations ; Chromosome Mapping ; *Chromosomes, Human, 1-3 ; *Chromosomes, Human, 4-5 ; Cricetinae ; Humans ; Hybrid Cells ; Kidney Neoplasms/genetics ; Lung Neoplasms/genetics ; Male ; Mice ; Nucleic Acid Hybridization ; *Oncogenes
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-07-06
    Beschreibung: Expression of the cellular abl (c- abl ) oncogene was studied in K-562 and other chronic myelogenous leukemia (CML) cells and cell lines by means of Northern blot hybridization. In contrast to non-CML cells, which contained 7.4- and 6.8-kilobase abl -related transcripts, the CML cells contained a predominant and novel 8.2-kilobase abl -related RNA. In addition, the levels of abl -related message were up to eight times higher in CML cell lines from patients at the blast crisis stage of the disease compared with CML cells obtained during the chronic phase and with non-CML cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, S J -- Kubonishi, I -- Miyoshi, I -- Groudine, M T -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):72-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587568" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; DNA, Neoplasm/genetics ; Humans ; Leukemia, Myeloid/*genetics ; Mice ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/genetics ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Nucleotide sequence of a human Blym transforming gene activated in a Burkitt's lymphoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-03
    Beschreibung: The nucleotide sequence of a human Blym-1 transforming gene activated in a Burkitt's lymphoma cell line was determined. This sequence predicts a small protein of 58 amino acids that is 33 percent identical to the predicted product of chicken Blym-1, the activated transforming gene of chicken B cell lymphomas. Both the human and chicken Blym-1 genes exhibit significant identity to an amino-terminal region of transferrins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, A -- Devine, J M -- Cooper, G M -- CA 07250/CA/NCI NIH HHS/ -- CA 28946/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):516-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330897" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Base Sequence ; Burkitt Lymphoma/*genetics ; Cell Line ; *Cell Transformation, Neoplastic ; DNA Restriction Enzymes ; Humans ; *Oncogenes ; Structure-Activity Relationship ; Transcription, Genetic ; Transferrin/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Human-proto-oncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-03
    Beschreibung: The nucleotide sequences of the six regions within the normal human cellular locus (c-sis) that correspond to the entire transforming region of the simian sarcoma virus (SSV) genome (v-sis) were determined. The regions are bounded by acceptor and donor splice sites and, except for region 6, resemble exons. Region 6 lacks a 3' donor splice site and terminates -5 base pairs from the 3' v-sis-helper-viral junction. This is consistent with a model proposing that SSV was generated by recombination between proviral DNA of a simian sarcoma associated virus and proto-sis and that introns were spliced out subsequently from a fused viral-sis messenger RNA. This also suggests that the 3' recombination occurred within an exon of the woolly monkey (Lagothrix) genome. The open reading frames predicting the v-sis and c-sis gene products coincide with the stop codon of c-sis located 123 nucleotides into the fifth region of homology. The overall nucleotide homology was 91 percent with substitutions mainly in the third codon positions within the open reading frame and with greatest divergence within the untranslated 3' portion of the sequences. The predicted protein products for v-sis and c-sis are 93 percent homologous. The predicted c-sis gene product is identical in 31 of 31 amino acids to one of the published sequences of platelet-derived growth factor. Thus, c-sis encodes one chain of human platelet-derived growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Josephs, S F -- Guo, C -- Ratner, L -- Wong-Staal, F -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):487-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318322" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Base Sequence ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Codon ; *Genes, Viral ; Humans ; *Oncogenes ; Platelet-Derived Growth Factor/*genetics ; RNA Splicing ; RNA, Messenger/genetics ; Recombination, Genetic ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/*genetics ; Viral Proteins/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-20
    Beschreibung: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-23
    Beschreibung: Platelet-derived growth factor (PDGF) has been previously shown to be homologous to the transforming gene of simian sarcoma virus (v-sis), and inappropriate expression of the cellular counterpart of the v-sis gene (c-sis) has been implicated in the generation of mesenchymal tumors. The U-2 OS human osteosarcoma line was shown to contain multiple c-sis transcripts. Immunoprecipitation experiments with antiserum to PDGF identified a variety of polypeptides ranging in size from 18,000 to 165,000 daltons that were immunoprecipitated specifically from U-2 OS cell extracts. The osteosarcoma also was shown to secrete a 29,000-dalton protein having the serological and structural characteristics of PDGF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graves, D T -- Owen, A J -- Barth, R K -- Tempst, P -- Winoto, A -- Fors, L -- Hood, L E -- Antoniades, H N -- CA30101/CA/NCI NIH HHS/ -- HL27607/HL/NHLBI NIH HHS/ -- HL29583/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):972-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6209798" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; DNA Replication ; Humans ; Molecular Weight ; Neoplasm Proteins/*genetics ; *Oncogenes ; Osteosarcoma/*genetics ; *Platelet-Derived Growth Factor ; Poly A/genetics/isolation & purification ; RNA/genetics/isolation & purification ; RNA, Messenger ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-10-19
    Beschreibung: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Activated expression of the N-myc gene in human neuroblastomas and related tumors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-14
    Beschreibung: In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N-myc genes is the result of (i) an increase in the absolute amount of expression of each N-myc gene and (ii) an increase in the copy number of the N-myc gene. A second gene--which is amplified in many of the same lines as N-myc--is expressed to about the same degree in most human cell lines and primary tumors regardless of origin (when normalized to gene copy number). Thus, a change in the regulation of N-myc expression in neuroblastomas and certain other tumors results in greatly increased expression of each N-myc gene copy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kohl, N E -- Gee, C E -- Alt, F W -- 2-P01 CA 23767-06/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 14;226(4680):1335-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505694" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; *Gene Amplification ; Gene Expression Regulation ; Humans ; Neuroblastoma/*genetics ; *Oncogenes ; RNA, Messenger/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-31
    Beschreibung: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    Oncogene linked to growth factor receptor (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):806.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320370" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Cell Cycle ; Humans ; *Oncogenes ; Receptor, Epidermal Growth Factor ; *Receptors, Cell Surface
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    What do oncogenes do? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):673-4, 676.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695176" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Genes, Viral ; Humans ; Neoplasms/*genetics ; *Oncogenes ; Repetitive Sequences, Nucleic Acid
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-10-19
    Beschreibung: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Autoimmunity and increased c-myb transcription (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-30
    Beschreibung: A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mountz, J D -- Steinberg, A D -- Klinman, D M -- Smith, H R -- Mushinski, J F -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494925" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Autoantibodies/*genetics ; Autoimmune Diseases/*genetics ; Female ; *Genes, Recessive ; Lymphocytes/immunology ; Lymphoproliferative Disorders/*genetics ; Mice ; Mice, Inbred Strains ; Nucleic Acid Hybridization ; *Oncogenes ; Species Specificity ; Spleen/immunology ; *Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-06
    Beschreibung: The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70gag-fgr is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naharro, G -- Robbins, K C -- Reddy, E P -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):63-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318314" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actins/analysis ; Amino Acid Sequence ; Base Sequence ; Computers ; Gene Products, gag ; *Genes, Viral ; *Oncogenes ; Protein Kinases/analysis ; Protein-Tyrosine Kinases ; Recombination, Genetic ; Retroviridae/*genetics ; Sarcoma Viruses, Feline/*genetics ; Viral Proteins/analysis/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Repression of rearranged mu gene and translocated c-myc in mouse 3T3 cells X Burkitt lymphoma cell hybrids (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-04-27
    Beschreibung: The productively rearranged immunoglobulin mu chain gene and the translocated cellular oncogene c-myc are transcribed at high levels both in human Burkitt lymphoma cells carrying the t(8;14) chromosome translocation and in mouse plasmacytoma X Burkitt lymphoma cell hybrids. In the experiments reported here these genes were found to be repressed in mouse 3T3 fibroblast X Burkitt lymphoma cell hybrids. Such repression probably occurs at the transcriptional level since no human mu- and c-myc messenger RNA's are detectable in hybrid clones carrying the corresponding genes. It is therefore concluded that the ability to express these genes requires a differential B cell environment. The results suggest that the 3T3 cell assay may not be suitable to detect oncogenes directly involved in human B cell oncogenesis, since 3T3 cells apparently are incapable of transcribing an oncogene that is highly active in malignant B cells with specific chromosomal translocations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nishikura, K -- ar-Rushdi, A -- Erikson, J -- DeJesus, E -- Dugan, D -- Croce, C M -- CA 09171/CA/NCI NIH HHS/ -- CA 10815/CA/NCI NIH HHS/ -- GM 31060/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):399-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6424234" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Burkitt Lymphoma/*genetics ; Fibroblasts ; *Gene Expression Regulation ; Genes ; Humans ; Hybrid Cells/*metabolism ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Mice ; *Oncogenes ; RNA, Messenger/genetics ; Transcription, Genetic ; *Translocation, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 18
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-31
    Beschreibung: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-17
    Beschreibung: Antisera to a synthetic c-myc peptide and to c-myc antigens synthesized from various portions of the human gene expressed in Escherichia coli were used in order to characterize the protein product of the human c-myc oncogene. Although the deduced molecular weight of the human c-myc protein is 49,000, these antisera precipitate a protein from human cells that migrates in sodium dodecyl sulfate-polyacrylamide gel as if its molecular weight were 65,000. In addition, the mouse c-myc protein, whether synthesized in cells or in a cell-free system directed by pure, synthetic messenger RNA, has analogous properties and is immunoprecipitated by the antiserum to the human c-myc protein. Similar proteins are immunoprecipitated from monkey, rat, hamster, and frog cells, suggesting evolutionary conservation of antigenic structure of the c-myc protein among vertebrates. In addition, and in a manner consistent with the behavior of its messenger RNA, the immunoprecipitable c-myc protein is sharply induced by the action of mitogens on resting human T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Persson, H -- Hennighausen, L -- Taub, R -- DeGrado, W -- Leder, P -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):687-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6431612" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antibodies, Neoplasm/*immunology ; Base Sequence ; *Cell Division ; Chickens ; Cricetinae ; DNA, Neoplasm/genetics ; DNA, Recombinant/metabolism ; Electrophoresis, Polyacrylamide Gel ; Haplorhini ; Humans ; Mice ; Mitogens/pharmacology ; Molecular Weight ; Neoplasm Proteins/genetics/*immunology ; *Oncogenes ; RNA, Messenger/genetics ; Rabbits ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-08
    Beschreibung: A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma cell lines but not in cell lines from other tumor types. N-myc has now been found to be amplified in neuroblastoma tissue from 24 of 63 untreated patients (38 percent). The extent of amplification appears to be bimodal, with amplification of 100- to 300-fold in 12 cases and 3- to 10-fold in 10 others. Amplification was found in 0 of 15 patients with stage 1 or 2 disease, whereas 24 of 48 cases (50 percent) with stage 3 or 4 had evidence of N-myc amplification. These data indicate that N-myc amplification is a common event in untreated human neuroblastomas. Furthermore, N-myc amplification is highly correlated with advanced stages of disease (P less than 0.001) and with the ability to grow in vitro as an established cell line, both of which are associated with a poor prognosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brodeur, G M -- Seeger, R C -- Schwab, M -- Varmus, H E -- Bishop, J M -- CA02971/CA/NCI NIH HHS/ -- CA13539/CA/NCI NIH HHS/ -- CA17829/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1121-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719137" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Aged ; Cell Line ; Child ; Child, Preschool ; DNA, Neoplasm/genetics ; Eye Neoplasms/genetics ; *Gene Amplification ; Humans ; Infant ; Lymphatic Metastasis ; Middle Aged ; Neuroblastoma/*genetics/physiopathology ; Nucleic Acid Hybridization ; *Oncogenes ; Prognosis ; Retinoblastoma/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-05-11
    Beschreibung: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-29
    Beschreibung: Avian erythroblastosis virus (AEV) contains two distinct oncogenes, erbA and erbB . The erbB oncogene, which is homologous to a portion of the epidermal growth factor receptor, is related to the src family of oncogenes and efficiently transforms erythroblasts, whereas erbA potentiates the effects of erbB by blocking the differentiation of erythroblasts at an immature stage. This "potentiator" was sequenced; the amino acid sequence deduced from it was clearly different from the sequences of other known oncogene products and was related to carbonic anhydrases. These enzymes participate in the transport of carbon dioxide by erythrocytes, the precursors of which are main targets of avian erythroblastosis virus. A src-related oncogene such as erbB in synergy with an activated specific cell-derived gene such as erbA can profoundly affect early erythroid differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Debuire, B -- Henry, C -- Bernissa, M -- Biserte, G -- Claverie, J M -- Saule, S -- Martin, P -- Stehelin, D -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1456-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328658" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alpharetrovirus/*genetics ; Avian Leukosis Virus/*genetics ; Avian Sarcoma Viruses/genetics ; Base Sequence ; Carbonic Anhydrases/genetics ; DNA, Viral/genetics ; Erythropoiesis ; Humans ; *Oncogenes
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 23
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    Somatic activation of rasK gene in a human ovarian carcinoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-17
    Beschreibung: A tumor isolate from a patient with serous cystadenocarcinoma of the ovary contained an activated rasK gene detected hy transfection of NIH/3T3 cells. In contrast, DNA from normal cells of the same patient lacked transforming activity, indicating that activation of this transforming gene was the consequence of somatic mutation in the neoplastic cells. The transforming gene product displayed an electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gels that differed from the mobilities of rasK transforming proteins in other tumors, indicating that a previously undescribed mutation was responsible for activation of rasK in this ovarian carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feig, L A -- Bast, R C Jr -- Knapp, R C -- Cooper, G M -- CA07101/CA/NCI NIH HHS/ -- CA18689/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):698-701.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695178" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cell Line ; Cell Transformation, Neoplastic ; Cystadenocarcinoma/*genetics ; DNA, Neoplasm/genetics/isolation & purification ; Female ; Humans ; Lung Neoplasms/genetics ; Mice ; *Oncogenes ; Ovarian Neoplasms/*genetics ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 24
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    Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-09-07
    Beschreibung: Treatment of mice with the carcinogen N-methylnitrosourea results in the development of thymic lymphomas with frequent involvement of the N-ras oncogene. The activated mouse N-ras gene was isolated from one of these lymphomas and, by transformation in concert with restriction digestion, a map of the gene was prepared and its approximate boundaries were determined. By means of somatic cell hybrids the normal N-ras gene was found to be unlinked to other members of the ras gene family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero, I -- Villasante, A -- D'Eustachio, P -- Pellicer, A -- CA-16239/CA/NCI NIH HHS/ -- GM-32105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1041-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089339" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Transformation, Neoplastic ; Chromosome Mapping ; Cloning, Molecular ; Cricetinae ; DNA Restriction Enzymes ; Deoxyribonuclease EcoRI ; Genetic Linkage ; Hybrid Cells ; Lymphoma/chemically induced/*genetics ; Methylnitrosourea ; Mice ; Mice, Inbred Strains ; *Oncogenes ; Thymus Neoplasms/chemically induced/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-09-14
    Beschreibung: Mouse tumors induced by gamma radiation are a useful model system for oncogenesis. DNA from such tumors contains an activated K-ras oncogene that can transform NIH 3T3 cells. This report describes the cloning of a fragment of the mouse K-ras oncogene containing the first exon from both a transformant in rat-2 cells and the brain of the same mouse that developed the tumor. Hybrid constructs containing one of the two pieces were made and only the plasmid including the first exon from the transformant gave rise to foci in NIH 3T3 cells. There was only a single base difference (G----A) in the exonic sequence, which changed glycine to aspartic acid in the transformant. By use of a synthetic oligonucleotide the presence of the mutation was demonstrated in the original tumor, ruling out modifications during DNA-mediated gene transfer and indicating that the alteration was present in the thymic lymphoma but absent from other nonmalignant tissue. The results are compatible with gamma radiation being a source of point mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero, I -- Villasante, A -- Corces, V -- Pellicer, A -- CA-36327/CA/NCI NIH HHS/ -- GM-32036/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 14;225(4667):1159-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474169" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cell Transformation, Neoplastic ; Cells, Cultured ; Cloning, Molecular ; Gamma Rays ; Lymphoma/*genetics ; Mice ; Mutation ; Neoplasms, Radiation-Induced/*genetics ; Nucleic Acid Hybridization ; *Oncogenes ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 26
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    Requirement for a signal sequence in biological expression of the v-sis oncogene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-12-07
    Beschreibung: The protein encoded by the simian sarcoma virus oncogene (v-sis) contains a signal sequence, derived from the envelope gene of the parental retrovirus, which is required for transformation. Removal of the proposed signal sequence was correlated with loss of biological activity. This activity was restored to inactive deletion mutants by fusion with the coding region for a heterologous signal sequence. Biological activity of v-sis was also abolished by either a small deletion within the coding region of the signal sequence or by a point mutation introduced by site-directed mutagenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hannink, M -- Donoghue, D J -- CA34456/CA/NCI NIH HHS/ -- GM07313/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1197-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6095451" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Transformation, Viral ; *Gene Expression Regulation ; Mutation ; *Oncogenes ; *Protein Biosynthesis ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/*genetics ; Viral Proteins/biosynthesis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-16
    Beschreibung: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-16
    Beschreibung: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 29
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    Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-10
    Beschreibung: The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Josephs, S F -- Ratner, L -- Clarke, M F -- Westin, E H -- Reitz, M S -- Wong-Staal, F -- New York, N.Y. -- Science. 1984 Aug 10;225(4662):636-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740330" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cebidae ; Cell Transformation, Neoplastic/*metabolism ; Codon ; DNA, Neoplasm/genetics ; Humans ; Nucleic Acid Hybridization ; *Oncogenes ; Platelet-Derived Growth Factor/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 30
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    A common onc gene sequence transduced by avian carcinoma virus MH2 and by murine sarcoma virus 3611 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-24
    Beschreibung: A common cellular sequence was independently transduced by avian carcinoma virus MH2 (v-mht) and murine sarcoma virus (MSV) 3611 (v-raf). Comparison of the nucleotide sequences of v-mht and v-raf revealed a region of homology that extends over 969 nucleotides. The homology between the corresponding amino acids was about 95 percent with only 19 of 323 amino acids being different. With this example, 5 of the 19 known different viral onc genes have been observed in viruses of different taxonomic groups. These data indicate that (i) the number of cellular proto-onc genes is limited because, like other viruses of different taxonomic groups, MH2 and MSV 3611 have transduced the same onc gene-specific sequences from different cell species and (ii) that specific deletion and linkage of the same proto-onc sequences to different viral vector elements affect the oncogenic potential of the resulting viruses. The difference in transformation capabilities of MH2 and MSV 3611 serves as an example.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kan, N C -- Flordellis, C S -- Mark, G E -- Duesberg, P H -- Papas, T S -- CA11426/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 24;223(4638):813-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320371" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alpharetrovirus/*genetics ; Animals ; Base Sequence ; Chickens/genetics ; Genes, Viral ; Mice ; *Oncogenes ; Sarcoma Viruses, Murine/*genetics ; Species Specificity ; Transduction, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 31
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    Primary structure of v-raf: relatedness to the src family of oncogenes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-04-20
    Beschreibung: A replication-defective, acute transforming retrovirus (murine sarcoma virus 3611) was isolated from mouse and molecularly cloned. The nucleotide sequence of 1.5 kilobases encompassing the transforming gene (v-raf) was determined. This sequence, which predicts the amino acid sequence of a gag-raf fusion protein, terminates 180 nucleotides from the 3' end of the acquired cellular sequence. Comparison of the predicted amino acid sequence of v-raf with the predicted amino acid sequences of other oncogenes reveals significant homologies to the src family of oncogenes. There is a lack of homology within the sequence of the tyrosine acceptor domain described for the phosphotyrosine kinase members of the src family of transforming proteins. Phylogenetic arrangement of this family of oncogenes suggests that tyrosine-specific phosphorylation may be a recently acquired activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mark, G E -- Rapp, U R -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):285-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6324342" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Base Sequence ; Binding Sites ; Biological Evolution ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; DNA Restriction Enzymes ; Gene Products, gag ; *Genes, Viral ; Mice ; *Oncogenes ; Protein Biosynthesis ; Protein Kinases/metabolism ; Protein-Tyrosine Kinases ; Sarcoma Viruses, Murine/*genetics ; Transcription, Genetic ; Tyrosine/metabolism ; Viral Proteins/analysis/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 32
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    Oncogene linked to cell regulatory system (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):527-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6093250" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenylyl Cyclases/*physiology ; Animals ; Cell Transformation, Neoplastic/metabolism ; Cyclic AMP/physiology ; Drosophila ; Guanosine Triphosphate/physiology ; Humans ; *Oncogenes ; Rodentia ; Yeasts
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 33
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    Tumor-prone mice--and myc (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):823.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494912" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; Mice ; Mice, Mutant Strains/*genetics ; Neoplasms, Experimental/*genetics ; *Oncogenes ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    The N-myc oncogene in neural tumors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1088.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719134" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Child, Preschool ; Eye Neoplasms/*genetics ; Humans ; Infant ; Neuroblastoma/*genetics ; *Oncogenes ; Retinoblastoma/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    New oncogene targets? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-04-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):272.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6324341" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 1-Phosphatidylinositol 4-Kinase ; Avian Sarcoma Viruses/*genetics ; *Cell Transformation, Neoplastic ; Diglycerides/metabolism ; Genes, Viral ; Inositol 1,4,5-Trisphosphate ; Inositol Phosphates/metabolism ; *Oncogenes ; Phosphatidylinositol Phosphates ; Phosphatidylinositols/*metabolism ; Phosphorylation ; Phosphotransferases/*genetics/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 36
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    Oncogenes amplified in cancer cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):40-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691135" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Transformation, Neoplastic ; Chromosome Aberrations ; *Gene Amplification ; Humans ; Leukemia/genetics ; Lung Neoplasms/genetics ; Neoplasms/*genetics/metabolism ; Neuroblastoma/genetics ; *Oncogenes ; RNA, Messenger/biosynthesis ; RNA, Neoplasm/biosynthesis ; Translocation, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 37
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    Perusing the myc gene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):675.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695177" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Burkitt Lymphoma/*genetics ; Chromosome Aberrations ; Chromosome Disorders ; Chromosomes, Human, 16-18 ; Chromosomes, Human, 6-12 and X ; Humans ; *Oncogenes
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 38
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    Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-13
    Beschreibung: Blym-1, a transforming gene detected by transfection of NIH 3T3 cells with DNA from Burkitt lymphomas, was mapped to the short arm of chromosome 1 (1p32) by chromosomal in situ hybridization. The Blym-1 gene was not physically linked to the cellular myc oncogene or to any of the immunoglobulin gene loci implicated in the characteristic chromosomal translocations in Burkitt lymphoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morton, C C -- Taub, R -- Diamond, A -- Lane, M A -- Cooper, G M -- Leder, P -- CA-21082/CA/NCI NIH HHS/ -- CA-33108/CA/NCI NIH HHS/ -- GM-17088/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 13;223(4632):173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691143" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Burkitt Lymphoma/*genetics ; Chromosome Aberrations ; Chromosome Mapping ; *Chromosomes, Human, 1-3 ; Genetic Linkage ; Humans ; Immunoglobulins/genetics ; Male ; Nucleic Acid Hybridization ; *Oncogenes ; Translocation, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 39
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    Retinoblastoma: clues to human oncogenesis (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-09
    Beschreibung: The retinoblastoma gene can be considered a model for a class of recessive human cancer genes that have a "suppressor" or "regulatory" function. The loss or inactivation of both alleles of this gene appears to be a primary mechanism in the development of retinoblastoma. Such a mechanism is in direct contrast to that of putative human oncogenes which are thought to induce tumorigenesis following activation or alteration. The high incidence of second primary tumors among patients who inherit one inactive retinoblastoma allele also suggests that this cancer gene plays a key role in the etiology of several other primary malignancies. Finally, the observation that extra nonrandom copies of specific chromosomal regions occur in some of these tumors provides circumstantial evidence that an "expressor" gene (possibly an oncogene) may be involved in retinoblastoma development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphree, A L -- Benedict, W F -- EY-02715/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1028-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320372" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/genetics ; Alleles ; Child ; Chromosome Deletion ; Chromosome Mapping ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 6-12 and X ; Eye Neoplasms/*genetics ; Genes, Recessive ; Genotype ; Humans ; Kidney Neoplasms/genetics ; Mutation ; Neuroblastoma/genetics ; *Oncogenes ; Polymorphism, Genetic ; Retinoblastoma/*genetics ; *Suppression, Genetic ; Translocation, Genetic ; Wilms Tumor/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 40
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    Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-08
    Beschreibung: Amplification is one of the mechanisms by which cellular oncogenes may be altered in their function, possibly leading to neoplastic transformation. The oncogenes c-myc, c- abl , and c-Ki-ras are amplified in several different human neoplasias. The oncogene c-myb, which is specifically expressed and regulated in hematopoietic cells, was found to be amplified in cell lines ML-1, ML-2, and ML-3, which were separately cultured from cells of a patient with acute myelogenous leukemia (AML). A five- to tenfold amplification was correlated with high levels of expression of normal size c-myb messenger RNA and with chromosomal abnormalities in the region 6q22 -24, where the c-myb locus is normally located. Amplification and cytogenetic abnormalities were detected in DNA's from primary and secondary cultures of ML cells, suggesting that they may have contributed to leukemogenesis. The similar AML cell lines HL-60 and ML's contain different amplified oncogenes: c-myc and c-myb, respectively. Alternative activation of structurally and possibly functionally similar oncogenes may distinguish--at the pathogenetic level--phenotypically similar tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pelicci, P G -- Lanfrancone, L -- Brathwaite, M D -- Wolman, S R -- Dalla-Favera, R -- P30 CA-16087/CA/NCI NIH HHS/ -- RR 05399/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1117-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585957" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; DNA, Neoplasm/genetics ; *Gene Amplification ; Humans ; Karyotyping ; Leukemia, Myeloid, Acute/*genetics ; Nucleic Acid Hybridization ; *Oncogenes
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 41
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-15
    Beschreibung: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 42
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    Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-17
    Beschreibung: Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65Kc-myc protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Persson, H -- Leder, P -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):718-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6463648" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Cell Nucleus/*metabolism ; Cell Transformation, Neoplastic/metabolism ; Chromatography, Affinity ; DNA, Neoplasm/*metabolism ; Humans ; Neoplasm Proteins/*metabolism ; *Oncogenes ; RNA, Messenger/metabolism ; Subcellular Fractions/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 43
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-02
    Beschreibung: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 44
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-08
    Beschreibung: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 45
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    Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-30
    Beschreibung: Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5' end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen-Ong, G L -- Potter, M -- Mushinski, J F -- Lavu, S -- Reddy, E P -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1077-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6093260" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Chromosome Deletion ; Cloning, Molecular ; DNA Restriction Enzymes ; DNA Transposable Elements ; *Genes, Viral ; Lymphoma, Non-Hodgkin/genetics/*microbiology ; Mice ; Mice, Inbred BALB C ; Moloney murine leukemia virus/*genetics ; *Mutation ; Nucleic Acid Hybridization ; *Oncogenes
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 46
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    Expression of cellular oncogenes in human malignancies (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-04-20
    Beschreibung: Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellular fes (feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slamon, D J -- deKernion, J B -- Verma, I M -- Cline, M J -- AM 18058/AM/NIADDK NIH HHS/ -- CA 15619/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):256-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6538699" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/genetics ; Breast Neoplasms/genetics ; Carcinogens/pharmacology ; Cell Differentiation ; Cell Division ; Cell Transformation, Neoplastic ; Female ; Gastrointestinal Neoplasms/genetics ; Gene Amplification ; Genes, Viral ; Genital Neoplasms, Female/genetics ; Humans ; Kidney Neoplasms/genetics ; Leukemia/genetics ; Lymphoma/genetics ; Methylation ; Mutation ; Neoplasms/*genetics ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/genetics ; RNA, Neoplasm/genetics ; Sarcoma/genetics ; *Transcription, Genetic ; Translocation, Genetic
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 47
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    Transcription and promoter usage of the myc gene in normal somatic and spermatogenic cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-11-09
    Beschreibung: In somatic cells the level of myc transcription is not restricted to particular cell types but correlates closely with the rate of cell division. Such transcription involves the use of two active myc promoters and produces two messenger RNA species that are differentially represented among the transcripts of different tissues. In apparent contrast to somatic cells, mitotically and meiotically dividing germ cells have very few myc transcripts and appear to proliferate, at least for a few divisions, in the absence of myc transcription. These results raise interesting questions regarding the role of the myc gene product in terminally differentiating cells, particularly of the germ line series.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stewart, T A -- Bellve, A R -- Leder, P -- HD06645/HD/NICHD NIH HHS/ -- HD08270/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 9;226(4675):707-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494906" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; Cell Division ; Male ; Meiosis ; Mice ; *Oncogenes ; *Operon ; RNA, Messenger/metabolism ; Sertoli Cells/physiology ; Spermatocytes/physiology ; *Spermatogenesis ; *Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 48
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    A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-03-16
    Beschreibung: Fetal guinea pig cells were transformed by treatment with four different chemical carcinogens including nitroso compounds and polycyclic hydrocarbons. As a consequence of this treatment, oncogenes capable of transforming NIH/3T3 cells became activated in each of five independently established clonal guinea pig cell lines. Molecular characterization of representative NIH/3T3 transformants revealed that the same oncogene was present in each of the cell lines tested. Moreover, detection of this transforming gene paralleled the acquisition of tumorigenic properties by these neoplastic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sukumar, S -- Pulciani, S -- Doniger, J -- DiPaolo, J A -- Evans, C H -- Zbar, B -- Barbacid, M -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1197-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322298" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Benzo(a)pyrene ; Benzopyrenes ; *Carcinogens ; Cell Division ; Cell Line ; *Cell Transformation, Neoplastic ; DNA Restriction Enzymes ; Diethylnitrosamine ; *Gene Expression Regulation ; Genes, Viral ; Guinea Pigs ; Methylcholanthrene ; Methylnitronitrosoguanidine ; Mice ; *Oncogenes ; Retroviridae/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-08-10
    Beschreibung: Early passages of the human teratocarcinoma cell line PA1 are not tumorigenic in nude mice, while late passages are. A transforming gene present in late passages of PA1 cells was isolated as a biologically active molecular clone and is a new isolate of the human rasN locus. Its transforming activity is due to a single G---A (G, guanine; A, adenine) point mutation at the codon for amino acid 12 which changes the codon for glycine so that an aspartic acid residue is expressed. In contrast to late passage PA1 cells (passages 106, 330, and 338), DNA from the PA1 cell line at early passages (passage 36) does not yield rasN foci in DNA transfection assays. Thus, the presence of an activated rasN in PA1 cells correlates with enhanced tumorigenicity of the cell line and, more importantly, may have arisen during cell culture in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tainsky, M A -- Cooper, C S -- Giovanella, B C -- Vande Woude, G F -- New York, N.Y. -- Science. 1984 Aug 10;225(4662):643-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740333" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; DNA, Neoplasm/genetics ; Humans ; Mice ; Mice, Nude ; *Oncogenes ; Teratoma/*genetics ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 50
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    Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-02-17
    Beschreibung: A single genetic alteration, a guanine-to-cytosine transversion, is responsible for the acquisition of malignant properties by K-ras genes of two human tumor cell lines established from carcinomas of the bladder (A1698) and lung (A2182). As a consequence, arginine instead of the normal glycine is incorporated into the K-ras-coded p21 proteins at amino acid position 12. This mutation creates a restriction enzyme polymorphism that can be used to screen human cells for transforming K-ras genes. This approach was used to identify the mutational event responsible for the malignant activation of a K-ras oncogene in a squamous cell lung carcinoma of a 66-year-old man; this point mutation was not present in either the normal bronchial or parenchymal tissue or in the blood lymphocytes. Hence, malignant activation of a ras oncogene appears to be specifically associated with the development of a human neoplasm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santos, E -- Martin-Zanca, D -- Reddy, E P -- Pierotti, M A -- Della Porta, G -- Barbacid, M -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):661-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695174" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; *Cell Transformation, Neoplastic ; DNA, Neoplasm/genetics ; Genes, Dominant ; Humans ; Lung Neoplasms/*genetics ; Mutation ; *Oncogenes ; Organ Specificity ; Polymorphism, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 51
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-05-25
    Beschreibung: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 52
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    Ode to gravity: Depth/diameter for fresh craters on Mercury (1984)
    In:  CASI
    Details
    Publikationsdatum: 2009-11-23
    Beschreibung: Opinions conflict over the role of surface gravity in shaping impact craters on Mercury. One view holds that the effects of g are evident in measurable aspects of crater form; other investigators find little or no evidence for g's geomorphic importance. Ambiguity in the role of g and other variables in cratering on Mercury stems largely from uncertainty in identifying major geomorphic contrasts and the crater sizes at which they occur. One of these, depth/diameter (d/D), undergoes a major change at the transition from simple (bowl shaped) to complex (peaks and terraces) crater interiors. Four least-squares d/D fits for fresh craters on Mercury were attemped. The results are inconsistent. The d/D data that should resolve previous shortcomings is presented. The revised d/D distributions for simple and complex craters, which intersect at a diameter of about 5 km, support the initial thesis that g substantially influences the form of Mercury's craters.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 104-106
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  • 53
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    Relationships and tectonics of the Jg-7 quadrangle of Ganymede (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Craters within the Ganymede Jg-7 quadrangle were divided into seven mappable units. The units represent: (1) irregular or elongate craters, (2) craters with dark ejecta, (3) palimpsests, (4) secondary craters, (5) and craters of young, mature, and old age. Symbols used for crater floors include: (1) flat floors, (2) floors with pits, (3) floora with a central dome or peak, (4) and floors with a central dome and pit. Grooved terrains were divided into five mappable units. Three units of light grooved material represent small, medium, and large grooves, which are arbitrarily divided. The other two units of grooved terrain represent dark grooved materials, and reticulate grooves. Two units of ungrooved dark terrain and two units of ungrooved light terrain were defined. In Galileo Regio, two units were defined repesenting large furrowed grooves, and smaller grooves which are orthogonal to the furrowed grooves.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 314-316
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  • 54
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    Mars paleostratigraphy (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: The relative time of emplacement of some major rock units on Mars was recognized to some degree from geologic mapping using Mariner Images. Correlation charts showing the map units and their position in sequence, however, displayed little discrimination in their vertical range of occurrence. A more detailed time-stratigraphy is currently being developed as Viking geologic mapping of the planet progresses.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 296-297
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  • 55
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    Mapping and geological analysis of Mercury radar data (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Although many radar profiles and images of the area within 20 deg of Mercury's equator had been obtained from 1971 to 1981, at both Goldstone and Arecibo radar facilities, surprisingly little geological analysis had been done with these data until recently. Topographic profiles and radar roughness reflectivity images which can be derived from these data will be crucial in completing the geological mapping of Mercury now underway at the U.S. Geological Survey. Processing of available radar data must be completed to establish any systematic relationship between radar reflectivities and roughness, density, dielectric constant, and other related geological parameters. Specific tasks accomplished for these purposes include the following. Documentation was located and searched to establish the type and quantity of Goldstone 12.5 cm radar observations which were available for Mercury. Data has been collected during approximately 50 observation periods from 1971 to 1981. About half of the data, collected during 1972 and 1973, have been processed, but without adequate documentation. A standardized, well-documented procedure for processing and analysis for all Goldstone Earth-based observations of Mercury was established.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 284-286
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  • 56
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    The case for aeolian control of meter-scale surface texture on Mars (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: The origin of Mars surface units and the extent of subsequent cratering play key roles in determining surface texture. At scale sizes of 0.1-10 meters, however, there is a growing body of evidence that wind is the dominant force. The direct and indirect evidence which implies that meter-scale surface texture on Mars is controlled by the wind is presented. Since radar is uniquely sensitive to structure on these scales, radio wave scattering data can provide insight on aeolian activity available from no other source.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 273-275
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  • 57
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    Ancient volcano-tectonic structures of the Olympus Mons Region, Mars (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Two old volcano-tectonic collapse structures are exposed north and northeast of the huge shield volcano, Olympus Mons. They are semicircular and were probably low shield volcanoes similar to Alba Patera, but whose central portions have subsided or collapsed. They form the basement upon which younger volcanic materials of Alba Patera Olympus Mons have been emplaced. The oldest structure, Acheron Fossae is over 700 km across and is north of Olympus Mons. It has a surface of considerable relief broken by graben and extensive en echelon and parallel fractures and faults with varied displacements. Acheron Fossae is the most densely cratered in the Olympus Mons region. The structure must have formed very early in martian time. The second is Halex Fossae, northeast of Olympus Mons. Where exposed, it is cut by a series of arcuate grabens that become closer spaced toward its center. The radii of the fractures indicate that the structure may be at least 250 km across and centered beneath the Olympus Plains. Lava flows appear to have issued from some of the arcuate fractures and to have flowed radially away from the center of Halex Fossae. North of Halex Fossae, material of the same age as Halex Fossae overlaps Acheron Fossae.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 293-295
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  • 58
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    Thermal infrared analysis of volcanic surfaces: Mars and Hawaii (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: High spatial resolution data from the Viking infrared thermal mapper (IRTM) are used to examine the Tharsis volcanoes which are situated within a vast area of low thermal inertia material very fine particle size or very high porosity, with the volcanoes having the lowest thermal inertias. Thermal infrared images of the 1823 flow on Kilauea's southwest rift zone show lower thermal inertias near the vent area where shelly pahoehoe is common while individual channelized aa flows with abundant broken pahoehoe slabs are higher thermal inertia. The increase in aa flows to the southeast leads to a general trend of increasing thermal inertias from near vent to distal areas. Martian shield volcanoes have thermal inertias equal to or higher than their surrounding plans when atmospheric effects are removed from the data. The general increase in thermal inertias away from the summit calderas is consistent with the trend of the Hawaiian 1823 flow and may be related to changing lava properties away from the summit.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 266-267
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  • 59
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    Galilean satellite multispectral data base production (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: A photometrically and geometrically reduced data base is being produced for the Galilean Satellites using Voyager Imaging data. The basic data set used is essentially all the useful satellite images returned by Voyager. Each frame was radiometrically calibrated and many are projected into cartographic formats. Mosaics of low, medium and high resolution frames being made for each satellite consist of registered digital images with intensity values scaled through a traceable calibration procedure to normal albedo values. Many of the mosaics are being made in two versions. One version is an albedo version and the second is a maximum discrimination version in which large variations in brightness across the picture are suppressed.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 259-260
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  • 60
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    Inversion of topography in Martian highlands terrains (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: One unique feature on Mars is the presence of ring furrows which are apparently produced by inversion of topography at the rims of partially buried craters. Ring furrows are flat-floored trenches, circular in plan view, forming rings 7 to 50 km in diameter. The moat is on the order of 0.5 km deep and 2 to 10 km wide, and it surrounds a flat topped circular mesa or plateau that is 5 to 40 km across. The central plateau is at the same elevation or lower than the surrounding plain outside the ring. The circular nature and size range of ring furrows tend to suggest that these features are related to craters partially buried by younger lava flows. The rings have been formed by preferential removal of the exposed crater rims. Ground ice decay, sapping, or fluvial erosion removed the less resistant, porous material of crater rims while leaving the more resistant volcanic flow material. Differential erosion has thus led to a reversal of topography in which the original positive relief of the rim is reduced to a negative relief feature.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 228-229
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  • 61
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    Permafrost on Mars: distribution, formation, and geological role (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: The morphology of channels, valleys, chaotic and fretted terrains and many smaller features on Mars is consistent with the hypothesis that localized deterioration of thick layers of ice-rich permafrost was a dominant geologic process on the Martian surface. Such ground ice deterioration gave rise to large-scale mass movement, including sliding, slumping and sediment gravity flowage, perhaps also catastropic floods. In contrast to Earth, such mass movement processes on Mars lack effective competition from erosion by surface runoff. Therefore, Martian features due to mass movement grew to reach immense size without being greatly modified by secondary erosional processes. The Viking Mission to Mars in 1976 provided adequate measurements of the relevant physical parameters to constrain models for Martian permafrost.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Programs; p 209-211
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  • 62
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    Dark streaks on talus slopes, Mars (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: High-resolution pictures of talus slopes on Mars show small, dark streaks that characteristically widen downward. These streaks are different from the thin and even streaks of various albedos that stream from cliffs on talus slopes, but gradations between the two streak types occur and not all streaks can be classified with confidence. In order to study the nature and origin of the small, widening, dark streaks, all Viking pictures with a resolution of less than 100 m/pixel were surveyed. To date several hundred streaks were located, but only few are of high enough resolution to be confidently identified as widening downwards. The approximate dimensions of the streaks were measured and their shapes, numbers, position, and spacing on slopes were noted. They were plotted on a topographic map, and their relation to topography, geologic units, and regions of distinct thermal inertia and albedo were studied. Also noted was the season at which images containing streaks were acquired and the direction of illumination. Albedo measurements are in progress. Several streaks can be seen stereoscopically, but none are observed on color images. The observation of small dark streaks on talus slopes on Mars is compatible with an interpretation of their origin as eruptions of small masses of wet debris in places where steep walls intersect aquifers or where seasonal equatorial warming permits the local melting of ground ice.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Programs; p 188-190
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    Freezing of Martian streams under climatic conditions (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: The valley networks of Mars are widely believed to have formed at a time when climatic conditions on the planet were significantly different from those that currently prevail. This view arises from the following observations: (1) the valleys form integrated branching networks which suggests fluid drainage, and water is the most plausible fluid, (2) the present atmosphere contains only minute amounts of water, (3) the networks appear to be more akin to terrestrial valleys that are eroded by streams of modest discharges than features that form by catastrophic floods, and (4) small streams of water will rapidly freeze under present climatic conditions. Climatic conditions at the time of formation of the valleys are studied based on the assumption that they were cut by running water.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Programs; p 185-187
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    Venus: The nature of the surface from Venera panoramas (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: Images of the surface of Venus obtained by the Soviet Venera 9, 10, 13 and 14 landers are analyzed to provide a basis for understanding the nature of geologic processes operating there. Bedrock is exposed at the Venera 10, 13 and 14 sites and is characterized by semi-continuous, flat polygonal to subrounded patches up to several meters in width. The bedrock surface is often dominated by sub horizontal to horizontal layered plates with thicknesses of several cm and abundant linear and polygonal vertical fractures. Soils (particles 1 cm) are abundant at the Venera 9, 10 and 13 sites, but are uncommon at Venera 14. Features indicative of a strong aeolian influence (moats, dunes, wind tails) are not observed. Several hypotheses are considered for the origin of the bedrock surfaces, and it is concluded that bedrock originated from surface lava flows. The relative freshness of features observed by the Veneras suggests that erosion rates are very low or that some bedrock surfaces are geologically young.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 76-78
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    Venus banded terrain: Evaluation of tectonic models for the origin of banding (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: A tectonic orgin for Venus banded terrain is consistent with band spacing. Both compressional (folding) and extensional models for band formation can fit present observations. Band spacing cannot distinguish among scenarios for global heat loss and for the origin of highland terrain. Tectonic models for band formation indicate that the surface brittle layer in the venus highlands is no more than a few kilometers thick.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 74-75
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    Wind abrasion on Venus: A means for experimental investigations (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: A study to determine the feasibility of conducting experiments to simulate the aeolian environment on Venus as related to wind abrasion was completed. Ideally, such experiments should involve complete investigation of weathering, in which mechanical, thermal, and chemical parameters are taken into account. This is particularly important for Venus, where atmospheric temperatures and pressures at the surface produce an environment which is equivalent to low or medium grade metamorphic conditions on Earth. Details that describe the Venus Aeolian Abrasion Device (VAAD) are included. The VAAD device would enable experiments to be conducted with the same chemistry, temperature, pressure, and other physical properties of the Venus atmosphere near the surface. The proposed device enables the important aeolian parameters to be controlled and monitored, including particle size, velocity, impact-angle and flux, atmospheric pressure, temperature, and gas composition.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 67-68
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    The Borealis Basin of Mars (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Why the lowlands of Mars are concentrated in the Northern Hemisphere and the highlands in the Southern Hemisphere is probably the most fundamental unsolved problem in martian geology. No explanation that accounts both for this asymmetric distribution and for the isostatic equilibrium across the scarp or sloping transition zone dividing the two provinces has been generally accepted; thinning of the lithosphere in the northern hemisphere by internal processes has been suggested. Because other lowland-highland distributions on Mars, Moon, and Mercury are controlled by impact basins, it is proposed that a giant basin formed early in Mars' history has caused the martian hemispheric dichotomy as well.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 110-112
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    Does saturation cratering exist in the solar system? (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: A number of researchers have concluded that saturation equilibrium cratering exists nowhere in the solar system, and therefore that diameter distributions in even the most heavily cratered provinces reveal initial production functions related to impacting bodies. Based on this premise, different populations of impactors are identified in different epochs and regions of the solar system. These hypotheses are clearly crucial to interpreting planetary history and need further independent examination. The production function in the outer solar system may differ from that in the inner solar system, but it is also possible that viscous relaxation of ice craters or immediate flooding of craters that penetrate through an ice lithosphere into watery substrate may explain the greater deficiency of large craters on icy moons. This problem is controversial and needs more study.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of the Planetary Geol. Program, 1983; p 97-99
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    Morphology of fresh craters on Ganymede and the origin of pedestal craters (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Properties of the planetary surface and subsurface can affect the morphology of impact craters. A mechanism was proposed to explain pedestal craters and domed floors within fresh craters on Ganymede. Voyager 1 and 2 images with resolutions = to or 3.2 km/lp were examined and 523 fresh craters were identified. For each crater, the rim and ejecta diameters were measured, and the crater was characterized by ejecta class(es), interior features, floor morphology and target terrain. Of the craters examined, 97 show moderate to prominent doming of the crater floor; 340 craters have continuous ejecta which terminates in a scarp pedestal craters, of which 86 (25%) have a high albedo diffuse deposit beyond the pedestal.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 94-96
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  • 70
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    Mercury: New identification of ancient multi-ring basins and implications for geologic evolution (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: A systematic survey of the entire Mariner 10 coverage of Mercury was performed to determine the number, distribution and dimensions of additional ancient basins on the planet. Ancient multi-ringed basins on Mercury can be recognized by the following criteria: (1) arcs of massif chains and isolated massifs that protrude through younger units, (2) arcuate segments of lobate ridges (rupes) that align with massifs in circular patterns, (3) arcuate scarps that are aligned with ridges and massif, and (4) isolated regions of anomalously high topography within the intercrater regions of heavily cratered terrain. All of the newly identified basins predate the mercurian intercrater plains, previously held to be the oldest geologic unit on the planet. Subsequent structural evolution of various regions was influenced by the presence of these basins. Smooth plains units appear to be more extensive than mapped by Mariner 10 and more than 90 percent of them appear to be basin contained or basin related. The concentration of extensive smooth plains material within and associated with basin structural and depositional environments suggests a volcanic origin for most of this unit, analogous to the lunar maria. Basins appear to provide the basic structural pattern of early terrestrial planetary crusts.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 87-89
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    Venus: Global distribution of Pioneer-Venus radar roughness and reflectivity and global correlation of altimetry, roughness and reflectivity observations (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: An improved version of the Pionner-Venus orbital data was used for a statistical analysis of global radar roughness and (alpha(0)) (rho) reflectivity. Classification maps of the venusian surface are produced in a supervised manner on the basis of statistical and empirical studies of the individual data sets. The primary objective is to assess the degree of homogeneity of surface radar properties within topographic provinces in order to map possible geologic boundaries. Maps were produced by correlating two data sets at a time. Classification of specific regions, such as Ishtar, has demonstrated that distinct geological units can be identified.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 81-82
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    New maps of Lakshmi Planum and eastern Aphrodite, Venus (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Interest on Venus has centered on three regions; (1) Aphrodite Terra, especially east of the main uplant portion, (2) Ishtar Terra, especially Lakshmi Planum and its bounding scarp and massifs, and (3) Beta Regio-Phoebe Regio. The last region is topographically similar to the East African rift system, and has been inferred to have a similar tectonic origin. The Aphrodite region is part of a 21,000 km long tectonic zone that seems best explained as due to extension, and that may represent hot spots clustered along an incipient divergent plate boundary. The most interesting and complex portion of this tectonic zone is that part of eastern Aphrodite between Thetis Regio and Atla Regio. In contrast, the Lakshmi Planum region has many topographic characteristics suggesting that it is a true continent, and thus indicative of convergence and a thick crust. Detailed topographic contour maps of eastern Aphrodite Terra and of Lakshmi Planum are included.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 71-73
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    Recent comet impacts on the moon: The evidence from spectral reflectance studies (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: The results of analyses of near infrared reflectance spectra are inconsistent with numerous previous interpretations of the Reiner Gamma Formation. These include: (1) nue ardente or volcanic ash deposits, (2) volcanically derived sublimates, (3) high albedo volcanic deposits, and (4) highlands debris emplaced as impact ejecta. These results, strongly suggest that the selective preservation of high albedo features (formed by secondaries) by a local magnetic field enhancement is not a viable hypothesis. The results are generally consistent with, but place constraints on, the cometary impact hypothesis of Schultz and co-workers. While the presence of a magnetized component was not detected in either the bright or dark portions of the Reiner Gamma Formation, this material may be present in amounts under the current detection limits.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 59-61
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    Cometary nucleus and active regions (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: On the basis of the icy conglomerate model of cometary nuclei, various observations demonstrate the spotted nature of many or most nuclei, i.e., regions of unusual activity, either high or low. Rotation periods, spin axes and even precession of the axes are determined. The observational evidence for variations in activity over the surfaces of cometary nuclei are listed and discussed. On June 11 the comet IRAS-ARAKI-ALCOCK approached the Earth to a distance of 0.031 AU, the nearest since C/Lexell, 1770 I, providing a unique opportunity for near-nucleus observations. Preliminary analysis of these images establishes the spin axis of the nucleus, with an oblioquity to the orbit plane of approximately 50 deg, and a lag angle of sublimation approximately 35 deg from the solar meridian on the nucleus. Asymmetries of the inner coma suggests a crazy-quilt distribution of ices with differing volatility over the surface of the nucleus. The observations of Comet P/Homes 1892 III, exhibiting two 8-10 magnitude bursts, are carefully analyzed. The grazing encounter produced, besides the first great burst, an active area on the nucleus, which was rotating retrograde with a period of 16.3hr and inclination nearly 180 deg. After the first burst the total magnitude fell less than two magnitudes from November 7 to November 30 (barely naked eye) while the nuclear region remained diffuse or complex, rarely if ever showing a stellar appearance. The fading was much more rapid after the second burst. The grazing encounter distributed a volume of large chunks in the neighborhood of the nucleus, maintaining activity for weeks.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 51-53
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    Geology of Dione (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: Dione is one of the most geologically complex of the Saturnian satellites. Crater counts and surface morphology indicates the geologic units observed are of variable age and origin. In an attempt to understand the processes which have affected Dione, a geologic map was prepared. Several geologic units were identified; ancient heavily cratered terrain, two plains units: cratered plains and lightly cratered plains, lobate deposits, crater rim deposits and bright wispy materials.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 34-36
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    Theoretical aspects of photoclinometric terrain profiling on the Galilean satellites (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: For large parts of the surfaces of the Galilean satellites there is no stereoscopic high resolution imagery, and so for shadow-free regions far from the terminator, the only method of obtaining topograpic information is photoclinometry, the technique of converting brightness variations into local surface tilts and hence into topographic profiles and contour maps. The conversion from brightness changes to slopes require knowledge of the angular photometric function for the type of planetary surface terrain being analyzed, i.e., the relationship describing the brightness of the surface as a function of the angles of incidence (I) and emergence (E) of light at a surface element. In order to investigate the effects of these changes on the shapes of topographic profiles deduced from the functions, an area of grooved terrain (lines 500-505, samples 550-650 on frame 20640.27 0060J2) using wide ranges of values of all the adjustable parameters in Hapke's new photometric function were analyzed.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 27-28
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    The structure of the Ionian lithosphere (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: Exploratory work on the structure of the Ionian lithosphere is reported. The approach is to examine temperature profiles within the lithosphere that result from different distributions of sulfur and silicates and different conductive heat fluxes, then compare such profiles with observations in the expectation that only a limited set of the profiles are possible. In this preliminary work some rather simplistic assumptions were taken and the report should be viewed more as a demonstration of a method rather than a presentation of results.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 11-13
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    Viking orbiter and its Mariner inheritance (1984)
    In:  CASI
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    Publikationsdatum: 2006-02-14
    Beschreibung: Improvements to the design of the Mariner spacecraft resulted in the Viking spacecraft. The Viking spacecraft would consist of two major systems - an orbiter and a lander, while the lander would provide the means for safely delivering the scientific instruments to the surface, house, and provide the necessary power source and communication links for those experiments, the orbiter would transport the lander to Mars, rovide a platform for the Viking imaging system so that proposed landing sites could be surveyed and certified, relay lander science information back to Earth, and conduct scientific observations in its own right.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: On Mars: Exploration of the Red Planet, 1958 - 1978; p 155-202
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    Compressional features in the Tharsis Region of Mars: Orientations and Timing of Deformation (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: The Tharsis ridge system appears to form a great circle around the major volcanoes. The roughly circumferential orientation of these ridges could be interpreted as the formation of a ridge system in response to a single stress field with a center near Pavonis Mons. Wise, et al. (1979) plotted the perpendiculars to strikes of ridges on the eastern flanks of Tharsis as great circles on the upper hemisphere of an equal area net. In order to further test for circular symmetry and possible other influences on ridge orientations, normals to vector means of ridge orientations were calculated using over 1850 digitized ridge segments sampled in 10 degree boxes. Orientations of individual ridge segments were weighted by their lengths, and the magnitudes of normals to vectors means were weighted by cummulative length of the ridge segments. Normals to vector means with magnitudes less than 100 km are not shown. Assuming a single fold origin for ridges, the resulting plot shows compressive stress trajectories for the ridges in the Tharsis region. The averaged compressive stress orientation around Tharsis confirm the suggestion by Wise, et al. that the ridge system is not concentric to any single point.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 304-306
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    Elysium Region, Mars: Characterization of tectonic features (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: In this paper the tectonic features of the Elysium region are identified and characterized. Identification of features was made using USGS controlled photomosaics (Elysium quadrangle, and portions of Amenthes and Cebrenia quadrangles); Viking Orbiter photographic data were used in individual cases to assist in identification. The positions and orientations of tectonic features can then be used, in conjunction with estimates of the mass of the volcanic load obtained from gravity modelling, to constrain the thickness of the elastic lithosphere in the region.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 291-292
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    Correction and geological analysis of lunar 3.8 CM radar data (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: Several 3.8 cm radar frames were calibrated empirically by histogram fitting, because no instrument background data is available. Then data were corrected for geometric distortion by: (1) redetermining position of individual frames using most accurate recent lunar ephemerides; (2) reprojecting frames into simple cylindrical map projection; (3) using most recent catalog of lunar craters to determine the exact positions of features identifiable on radar frames; and (4) correcting for apparent distortion (misplacement of features in frames) by resampling using a different bilinear interpolation derived for each of the parallelopideds of the set defined for each frame. A hardcopy set of corrected frames was produced. Attempts to produce a mosaic of such corrected frames continue. The resulting mosaic can be used to show the systematic relationship between photographic thermal IR and radar data at different wavelengths in a region dominated by both mare and highland terrain.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 282-283
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    Compressional features in the Tharsis Region of Mars: Geographic (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: Studies of the stratigraphy of southwest Coprates have led to further constraints on both the geographic extent and the relative age of the major compressional ridge forming events in the Tharsis region of Mars. Southwestern Coprates is characterized by curvilinear ridges that are regularly spaced, suggestive of harmonic folding. The western edge of the ridged plains unit of Coprates is marked by volcanic flow fronts. In an enhanced Viking-Orbiter image, a ridge can be seen completely surrounded by a flow with only a small portion of the ridge crest still exposed. Comparison of partially buried ridges on the western edge of the ridged plains to those in central Coprates suggests that flooding of the inter-ridge plains does not exceed a few hundred meters. The morphological relationship between the flow units to the west and the ridged plains indicates that the deformational events in this region predates the emplacement of the younger units.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 301-303
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    Valles Marineris layered deposits: Implications of origin (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: Layered deposits within Valles Marineris and its associated system of canyons have been considered to consist of two different rock types: (1) thick, competent, cliff-forming, light and dark bedded material in canyon walls, and (2) relatively thin, alternating series of light and dark layered material, both horizontal and inclined, that form rounded hills and large flat-topped mesas rising above the canyon floors. The dissimilarity in appearance between canyon wall and floor materials, as well as their contrasting patterns of erosion, have been considered strong evidence that their modes of origin were different.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 298-300
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    Scarp development in the Valles Marineris (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: The scarps along the margins of the Vales Marineris display a complex assemblage of forms that have been related to a variety of mass wasting and sapping processes. These scarp segments display variations in the degree of development of spur and gully topography, the number and density of apparent sapping features and the frequency of large scale landslides which reflect the age, geology and processes of slope development throughout the Valles Marineris. This regional analysis should provide more information on the geologic evolution of the Valles Marineris as well as new insight into the relative importance of different processes in the development of the scarp forms. In order to evaluate the regional variation in scarp form and the influence of time and structure on scarp development geomorphic mapping and morphometric analysis of geologically distinct regions of Valles Marineris is being undertaken.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 234-236
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    Weathered stony meteorites from Victoria Land, Antarctica, as possible guides to rock weathering on Mars (1984)
    In:  CASI
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    Publikationsdatum: 2006-04-06
    Beschreibung: Parallel studies of Martian geomorphic features and their analogs on Earth continue to be fruitful in deciphering the geologic history of Mars. In the context of rock weathering, the Earth-analog approach is admirably served by the study of meteorites recovered from ice sheets in Antarctica. The weathering environment of Victoria Land possesses several Mars-like attributes. Four of the five Antarctic meteorites being studied contain rust and EETA79005 further possesses a conspicuous, dark, weathering rind on one side. Secondary minerals (rust and salts) occur both on the surfaces and interiors of some of the samples and textural evidence indicates that such secondary mineralization contributed to physical weathering (by salt riving) of the rocks. Several different rust morphologies occur and emphasis is being placed on identifying the phase compositions of the various rust occurrances. A thorough understanding of terrestrial weathering features of the meteorites is a prerequisite for identifying possible Martian weathering features (if such features exist) that might be postulated to occur in some meteorites.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 216-218
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  • 86
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    Dust streaks on Mars: Colors and photometry (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Photometric studies of crater related bright and dark streaks have strongly supported the hypothesis that the bright streaks are excess dust deposits and dark streaks are erosional windows in a partial dust cover. Red-blue (and red-violet) plots show that bright streaks are consistent with mosaics of bright red dust and background material. Here the plains are also consistent with a partial dust cover; the dark streak is the least covered area. Bright and dark streaks both reverse contrast relative to surrounding plains at phase angles over 100 deg in violet filter images. The similar phase behavior of both bright and dark streaks supports the idea that they are both changes in the amount of dust cover. Red-violet plots of bright streaks are most easily explained by mosaics of optically thick dust and plains material. Lengths of bright streaks are independent of their contrasts. This suggests the streak deposition, if in the mosaic patterns indicated above, is a function of available sites of deposition, rather than atmospheric dust loading. Contrasts of dark streaks with plains indicate the plains have fractional dust covers nealy as great as the maximum additional cover in bright streaks. The bright streaks thus store little of the global supply of dust.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 161-162
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  • 87
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    Martian dust storms witnessed by Viking Lander 1 (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Viking Lander 1 observations on Mars were punctuated by a strong local dust storm after two martian years of mild wind conditions. Tens of micrometers of dust settled to the surface during global dust storms of the first two falls and winters; some of this dust was locally removed during the second year. A late winter local dust storm of the first year caused little or no erosion of the surface materials despite wind speeds of 25 to 30 m/s. The strong local dust storm occurred during late winter of the third martian year. Winds of this storm altered and demolished small conical piles of surface materials constructed at the onset the first winter, removed 4 to 5 mm size fragments, displaced centimeter size fragments, destroyed clouds in areas disrupted by the sampler and footpad, eroded impact pits, and darkened the sky. Movement of erosional products and tiny wind tails indicate easterly to northeasterly winds. If the 4 to 5 mm size fragments were entrained and removd by the wind, threshold friction speeds near 3 to 5 m/s would have been required for the atmospheric temperatures and pressures that prevailed during the late winter of the third year.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 158-159
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  • 88
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    Geomorphic clues to the Martian volatile inventory. 1: Flow ejecta blankets (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: There are classes of landforms whose presence on Mars is strongly suggestive, if not confirmatory, of the participation of volatiles, presumably water, in its geomorphic development: (1) valley networks, (2) outflow channels, (3) landslides, and (4) flow-ejecta blankets. The first two may represent landforms generated by the movement of volatiles from sources, while the latter two probably represent the dissipation of energy generated by forcing inputs (e.g., kinetic energy and gravity) modulated by volatiles. In many areas on Mars, all four processes have acted on the same lithologic materials and were influenced by the composition of those units, and possibility by the climatic regime at the time of their formation. One of the approaches discussed to this specific problem of landform genesis, and to the general problem of the present and past states of martian volatiles, is to attempt to constrain the distribution, amount, and history of available volatiles by using possible evidence of volatile participation expressed in the morphology of other related landforms (e.g., flow-ejecta blankets and landslides) coupled with physical models for landform genesis.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 116-118
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  • 89
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    Progressive impact cratering (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Most cratering experiments are designed to study the effects of a single hypervelocity impact into a target of uniform properties. Experiments involving multiple impacts are usually limited to low velocity projectiles and unconsolidated target materials. Gault described saturation cratering in an unconsolidated target. Quaide and Oberbeck studied crater forms produced by hypervelocity impact into layered targets. Several investigators have modeled the generation of either a regolith or megaregolith by repeated impact on planetary surfaces. Studies now in progress examine changes in crater morphology and target properties by repeated impact into an initially consolidated target. Current studies employ low velocity projectiles (2 g at 0.5 km/sec) and consolidated salt targets. Records of crater size, morphology, and accumulated ejecta thickness are maintained as impacts collect on the surface.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 102-103
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  • 90
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    Martian crater size distributions and terrain age (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: The crater size/frequency distributions of large ( 8 km) craters on the Moon and terrestrial planets display two very different curves representing two crater populations. The heavily cratered regions of the Moon, Mercury, and Mars show the same highly structured curve which cannot be represented by a single slope distribution function. In contrast, the lunar post mare crater population has a size/frequency distribution which differs significantly from that in the highlands over the same diameter range, and can be represented by a single-slope distribution function of -2.8 differential. On areas of martian lightly cratered northern plains, the crater population is essentially identical to that of the post mare population. This indicates that the same two families of impacting objects were responsible for the cratering records on both Moon and Mars. The thickness of mantling material varies among the various plains units, and can be calculated from the depth/diameter scaling relations for martian craters.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 85-86
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  • 91
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    A generalized behavioral model for rotating short period comets with spectral orbital elements and axial orientation (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: A generalized model for short period comets is developed which integrates in a fairly rigorous manner the isolation history of regions on rotating comets with specified axial orientation and the complex feedback processes involving heat, gas and dust transport, dust mantle development and coma opacity. Attention is focused on development, reconfiguration and partial or complete launching of dust mantles and the reciprocal effects of these three processes on ice surface temperature and gas and dust production. The dust mantle controls the H2O flux not only by its effect on the temperature at the ice interface but (dominantly) by its dynamic stability which strongly influences vapor diffusivity. The model includes the effects of latitude, rotation and spin axis orientation are included and applied to an initially homogeneous sphere of H2O ice and silicate using the orbital parameters of comet Encke. Numerous variations of the model, using combinations of grain size distribution, dust-to-ice ratio, latitude and spin axis orientation, are presented and discussed. Resulted for a similar nonrotating, constant Sun orientation models are also included.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 54-55
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  • 92
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    Short time-scale surface changes on Io (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Imaging data from the Voyager 1 and 2 encounters with the Jupiter system provide a data set for the examination of short time-scale variations of surface features on Io. Clear evidence exists for variations near the known eruption sites and for other areas which appeared to have erupted between the encounters. Regions outside the known active eruption sites were examined in order to look for variations in the surface scattering properties which is due to undetected small-scale volcanic activity. The phase functions of many areas are intercompared in order to look for regions with phase functions outside the normal range for satellite surface properties. Areas with unusual scattering properties are related to small-scale eruptions of gas or particles. Determination of the distribution of these areas has strong implications for the resurfacing rates for Io.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 39-40
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  • 93
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    Topography on Ganymede derived from photoclinometry (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: A fundamental limitation in the quantitative analysis of planetary geomorphology and structural geology results from the absense of topographic data. Among the studies that might be addressed, were such data available, are volumetric and slope relationships of Ionian volcanics, fracture and annealing processes in icy crusts on Europa and Ganymede, and evaluation of viscous relaxation as a means of degrading landforms on Europea, Ganymede, and Callisto. A technique for acquiring topographic data on the Galilean satellites using photoclinometry was developed and applied.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 29-31
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  • 94
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    The Laplacian resonance and tidal dissipation (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: The Laplacian resonance amongst Io, Europa, and Ganymede was examined, taking into account tidal dissipation in Jupiter, Io and Europa. In equilibrium, it is not possible to neglect dissipation in Europa nor the torques of Jupiter on Europa and Ganymede. A formal calculation was made on the assumption that the tidal torques and the torques in orbit-orbit resonance reached an equilibrium such that the rates of decrease of the mean motions of the satellites are in the ratios 4:2:1. Q(j)/k(j)=167 Q(1)/k(1), Q(2)/k(2) = 0.44 Q(1)/K(1), where Q denotes the quality at the body's frequency of rotation, k its second degree Love number and the subscripts J, 1 and 2 denote Jupiter, Io, and Europa. The Q(J) found is at Jupiter's frequency of rotation. The rate of tidal dissipation in Europa comes to 1/5 that of Io. Such a low value of Q(2)/K(2) is plausible if dissipation in both Io and Europa is due to tidal friction in fluid against underlying and overlying solid layers.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 8-10
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  • 95
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    High-resolution color images of Io (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Color versions of the highest resolution Voyager images of Io were produced by combining the low resolution color images with the high resolution, clear filter images. High resolution versions of the orange, blue, and violet filter images are produced by: orange = high-res clear * low-res orange / low-res clear blue = high-res clear * low-res blue / low-res clear violet = high-res clear * low-res violet / low-res clear. The spectral responses of the high and low resolution clear filter images cancel, leaving the color, while the spatial frequencies of the two low resolution images cancel, leaving the high resolution.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 38
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  • 96
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    Modeling Io volcanism: Maximum volcanic temperatures, depths of melting and magma composition (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Interim results of thermal and structural modeling of volcanism on Io were presented. The final results of the modeling are summarized. The basic analysis is an evaluation of the magma trigger mechanism for initiating and maintaining eruptions. Secondary aspects include models of the mechanical mode of magma emplacement, interactions with a sulphur-rich upper crust, and more speculative implications for Io's volcanism.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 14-16
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  • 97
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    Origin and evolution of the Saturn system (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: As was the case for Jupiter, Saturn formed either as a result of a gas instability within the solar nebula or the accretion of a solid core that induced an instability within the surrounding solar nebula. In either case, the proto-planet's history is divided into three major stages: early, quasi-hydrostatic evolution (stage 1); hydrodynamical collapse (stage 2); and late, quasi-hydrostatic contraction (stage 3). During stage 1, Saturn had a radius of several hundred times that of its present radius, R(s), while stage 3 began when Saturn had a radius of 3.5 R(s). Stages 1 and 2 lasted 10(6) to 10(7) years and 1 year, respectively, while stage 3 is continuing through the present epoch. During the early history of the Saturn system, giant impact events may have catastrophically disrupted most of the original satellites of Saturn. Such disruption, followed by reaccretion, may be responsible, in part for the occurrence of Trojans and co-orbital moons in the Saturn system, the apparent presence of a stochastic component in the trend of satellite density with radial distance, and the present population of ring particles.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Repts. of Planetary Geol. Program; p 6-7
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  • 98
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    Hypsometric studies of Mars. (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Altitude data derived from the 12.6 cm radar measurements obtained at JPL's Goldstone Facility were used to explore the utility of this type of regional analysis and to develop criteria for the interpretation of hypsometric data for planets where no visual images are available. Examination of the radar-derived hypsogram for Mars shows that the unimodal distribution of elevations contains several second order peaks and is skewed toward a modal elevation of about 3.5 km above the 6.1 mb datum. Individual topographic features can be recognized from this hypsogram, but such interpretations are based on the known surface morphology that has been determined from spacecraft images. It is not yet known how, for example, cratered terrain, regional slopes or other morphological features could be identified using the hypsogram if no images were available for ground-truth. The role that large impact craters play in influencing the shape of a hypsogram is being studied.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 279-281
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  • 99
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    Multi-image photometric solutions for the Galilean satellites (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: A method for determining the limb darkening planet, acquired in the same wavelength range (lambda), within a few degrees of the same phase angle (alpha), but acquired at different illumination and viewing conditions. The two images are first geometrically registered in simple cylindrical format. A limb darkening factor is computed for each pixel pair and output as a digital image. Systematic trends with photometric coordinates across this image indicate either a calibration error or inappropriateness of the particular photometric function. This method can be used for any photometric function with a single limb darkening factor, such as the Minnaert function or the function which combines the Lommel-Seeliger and Lambert functions. By solving for many pairs of images, the limb darkening factor as a function of alpha and lambda may be determined. The two image limb darkening solutions determined for 1 Voyager image pair on Ganymede, 16 image pairs on Callisto, 44 pairs on Europa, and 19 pairs on Io are discussed.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 261-262
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  • 100
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    Surface compositions in the Aristarchus Region: Implications for regional stratigraphy (1984)
    In:  CASI
    Details
    Publikationsdatum: 2006-04-06
    Beschreibung: Near infrared reflectance spectra for the Aristachus region, obtained using the 2.2m UH telescope at the Mauna Kea Observatory, were reduced and analyzed. The spectra obtained for the central peak, southern floor, southwestern wall, eastern wall, and northwestern wall of Aristachus crater exhibit shallow continuum slopes, relatively strong feldspar bands, pyroxene bands stronger than those typically seen in the spectra of fresh higland features, and pyroxene band centers near l micrometer suggesting the dominance of Ca rich clinopyroxene. The spectrum of the south rim of Aristachus is quite distinct from those of other crater units. The position of Aristrchus on the plateau/mare boundary raises questions concerning compositional variations in crater ejects deposits.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA. Washington Rept. of Planetary Geology Program, 1983; p 250-252
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