Publication Date:
1984-03-16
Description:
Fetal guinea pig cells were transformed by treatment with four different chemical carcinogens including nitroso compounds and polycyclic hydrocarbons. As a consequence of this treatment, oncogenes capable of transforming NIH/3T3 cells became activated in each of five independently established clonal guinea pig cell lines. Molecular characterization of representative NIH/3T3 transformants revealed that the same oncogene was present in each of the cell lines tested. Moreover, detection of this transforming gene paralleled the acquisition of tumorigenic properties by these neoplastic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sukumar, S -- Pulciani, S -- Doniger, J -- DiPaolo, J A -- Evans, C H -- Zbar, B -- Barbacid, M -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1197-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322298" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Benzo(a)pyrene
;
Benzopyrenes
;
*Carcinogens
;
Cell Division
;
Cell Line
;
*Cell Transformation, Neoplastic
;
DNA Restriction Enzymes
;
Diethylnitrosamine
;
*Gene Expression Regulation
;
Genes, Viral
;
Guinea Pigs
;
Methylcholanthrene
;
Methylnitronitrosoguanidine
;
Mice
;
*Oncogenes
;
Retroviridae/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink