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  • 1
    Keywords: Medical genetics. ; Pediatrics. ; Medical Genetics. ; Pediatrics.
    Description / Table of Contents: Current debate about definitions and the incidence of DSD (Disorders of Sex Development) -- The Molecular Basis of Gonadal Development and DSD .-Embryology of the Human Genital Tract -- Hormones Regulating Sex Development -- Questions About Gender: Children with Atypical.-Abnormal Embryology in DSD -- 46,XX DSD -- 46,XY DSD -- Mixed Sex Chromosome and Ovo-Testicular DSD -- Non-hormonal DSD -- Multiple Malformation Syndromes in DSD -- The Neonate with Ambiguous Genitalia -- DSD Later in Childhood -- The Adolescent or Young Adult with DSD -- Imaging in DSD -- Ethical Principles for the Management of Children with Disorders of Sex Development: A Systematic Approach for Individual Cases -- The Medical Management of DSD -- Surgical Treatment in Infancy -- Laparoscopy for DSD -- The Family -- Genetic Counselling -- Cultural Differences and Controversies about Timing of Management -- A Long-Term Outcome Study of DSD in Melbourne -- Medical Management of Adolescents and Young Adults -- Gynaecological Management -- Psychological Management in Adolescence and Beyond -- Short-, Medium- and Long-Term Outcomes Following Surgery for DSD at Royal Children’s Hospital -- Long-Term Outcome of DSD: A World View -- Psychosocial issues and mental health in DSD patients -- Complete Androgen Insensitivity Syndrome: A Guide for Parents and Patients -- Perspectives of patients, families and support groups -- Additional Material .-Video .-Index.
    Abstract: The new, fully updated edition of this successful book, brings together the combined experience of a leading dedicated unit over 25 years in delivering expert medical and surgical care to children with DSD (Disorders/Differences of Sex Development) in a holistic environment. It documents the most recent advances in the molecular biology and embryology of sex development, and describes each variation in detail. The main focus of the book is on patients with variations with their anatomy and hormone function. New chapters describe the developments in the field in terms of definitions and incidence, the mental health of DSD patients and discuss the perspectives of patients families and support groups. The clinical presentation and approach to diagnosis are described both for babies and for children presenting later in childhood or at adolescence. The chapters on management highlight all the latest knowledge and include the shared wisdom of the authors on current controversies, such as the timing of surgical treatment. Finally, the authors describe their short-, medium-, and long-term outcomes, which demonstrate the strengths of holistic team management.
    Type of Medium: Online Resource
    Pages: XII, 362 p. 154 illus., 80 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9789811378645
    DDC: 616.042
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Biomaterials. ; Nucleic acids. ; Biotechnology. ; Medical Genetics. ; Nucleic Acid. ; Biotechnology.
    Description / Table of Contents: 1. RNA-Composition and Base Pairing -- 2. Architecture of RNA -- 3. Small Catalytic RNA -- 4. The Spliceosome: A Large Catalytic RNA -- 5. A Genomic Perspective on RNA -- 6. The mRNA and the New Vaccines -- 7. Riboswitches: Sensors and Regulators -- 8. Small Non-Coding RNA, miRNA in Gene Regulation -- 9. CRISPR-Cas Systems, The science and ethics of gene manipulation -- 10. Transcription.
    Abstract: This highly illustrated textbook provides an essential overview on RNA architecture and function, it offers insights into the RNA basics and also explains novel RNA technologies, such as CRISPR-Cas and their applications. In addition, the mRNA based vaccine technology, which has long been tested, also before the COVID-19 pandemic, is discussed and students receive a basic understanding of this important medical application. The textbook is written by Prof. Grover in collaboration with her students and has an easily accessible style. The book provides a great tool for young researchers and students in biology, biomedical engineering or biochemistry, looking for a compact introduction or refresher work on RNA, including the newest findings and technologies. It is an ideal starter to learn about several RNA specific topics and to research them further.
    Type of Medium: Online Resource
    Pages: XVI, 246 p. 108 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030902148
    Series Statement: Learning Materials in Biosciences,
    DDC: 616.042
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pollution. ; Environmental geography. ; Water. ; Hydrology. ; Sociology, Urban. ; Economic development. ; Pollution. ; Integrated Geography. ; Water. ; Urban Sociology. ; Development Studies.
    Description / Table of Contents: Introducing Urban Health and Wellbeing -- Urban environment of Delhi and Mumbai -- Changing Urban Environment in Megacities: Delhi and Mumbai -- Urban micro climates: Delhi and Mumbai -- Urban Health Risk Analysis: Delhi and Mumbai -- Policy initiatives and other mechanisms.
    Abstract: This book focuses on interdisciplinary issues of human health in the changing urban environments of India’s largest megacities—Delhi and Mumbai. The authors explore human health concerns related to increased temperatures and air pollution in these cities in a study based on primary data collected through interviews, as well as secondary data on causes of mortality from 2001 to 2012. During this period, the surface temperatures for both megacities were mapped using Landsat Images. The rapidly increasing populations of cities and urban centers alter ecosystem services such as water, air and land cover, with disastrous impacts on health and wellbeing, particularly in megacities. In 2015, polluted air was estimated to have been responsible for 6.4 million deaths worldwide, and it is projected that it will cause between 6 and 9 million deaths per year by 2060. In 2017, outdoor air pollution resulted in 1.2 million deaths in India and brought about a 3% loss in GDP. The increase in population, vehicles, and industries has led to changes in land use and land cover and a rise in city temperatures and air pollution, creating urban heat islands (UHIs). Together, UHIs and air pollution have damaging impacts on human health that range from stress and headache to asthma, bronchitis, and chronic diseases, and even to death. Delhi has been experiencing emergency conditions in terms of environmental health over the past two years. At the same time, both the Delhi and Mumbai urban agglomerations are growing at a rapid pace, and the United Nations has projected that they will be the second and third most populous cities in the world by 2025. In this context, the book offers significant insights into the past patterns and responses to the present global urban health emergencies, and explores sustainable means of combating the problem to enable college and university researchers to develop innovative solutions. Further. It presents trans-disciplinary research that cuts across the WHO Action Plan, the Sustainable Development Goals, the Sendai Framework for Disaster Risk Reduction, and Habitat III to help policymakers gain a better understanding of the global challenges of urban health and wellbeing. The book is especially useful for students and researchers in geography, urban demography, urban studies, environmental studies, health sciences, and policy studies.
    Type of Medium: Online Resource
    Pages: XXXIV, 273 p. 131 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811366710
    Series Statement: Advances in Geographical and Environmental Sciences,
    DDC: 363.73
    Language: English
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  • 4
    Keywords: Sustainability. ; Medical sciences. ; Food security. ; Nutrition   . ; Well-being. ; Sustainability. ; Health Sciences. ; Food Security. ; Nutrition. ; Well-Being.
    Description / Table of Contents: Appraising Visioning Sustainability for a Healthy and Happy Future -- Sustainable Health in Territorial Planning -- Food Consumption Patterns and Associated Health Risks in Douala Metropolis – Cameroon -- Geostatistical Study on Waterborne Disease Outbreak in India [2011-2020] -- Peri-urban Agriculture and Food Supply -- Gender Dimension of Child Malnutrition among Tribal Children in India -- Food Processing and Nutrition Delivery -- Undernutrition Among the Adult Tribal Populations of India: Review and Meta-analysis -- The Food and Nutrition Status in India: A Systematic Review -- Spirituality in Sustainable Mental Health Protection: Evidence from Vocational Training of Information Technology Professionals -- Physical Activity as a Vital Element of the Development of the Concept of Healthy Cities (SDG 3 and 11) with a Role of Local Governments (SDG 17) -- Body Mass Index and Healthy Lifestyle among Adolescent Girls: A Case Study on Delhi -- Can Doctor's Resource Allocation Improve Residents' Health?: Price, Quality, Patient Mobility -- The Role of Urban Gardening in Global Cities: Three Case Studies in Berlin, Rome and Tokyo -- Distributional Analysis and Access to Fresh Fruits and Vegetable Shops in Residential Neighborhoods of Birnin-Kebbi Metropolis, Nigeria: Implications for Informal Landuse Planning -- Nutrition, Lifestyle and Health Status among Tribal Communities: A Case Study of Particularly Vulnerable Tribal Group of Kerala -- Living with Reduced HIV/AIDS Stigma & Discrimination: A Grounded Theory Analysis of Infected Migrants -- Towards Sustainable Understanding of Health: Perception and Worldview on Erectile Dysfunction Nigeria -- An Integrated Enviro-Psychological Approach to Health. .
    Abstract: This book uncovers the multiple layers of challenges posed to achieve sustainable human health and improves the understanding of interactive areas set by the UN Sustainable Development Goals (1) no poverty, (2) zero hunger, (3) good health and wellbeing, (6) clean water and sanitation, and (11) sustainable cities and communities. The book focuses on conceptual understanding, food, nutrition, lifestyle, and their integration to reinforce the ideas of holistic health principles.' The most important drivers of sustainable health are food, nutrition, and lifestyle. Healthy food is a basic need of human beings. In under-developed regions, people are underweight and facing malnutrition, with a prevalence of deficiency diseases due to low intake of micro-nutrients such as vitamin A, iodine, and protein among others. A good diet as well as lifestyle has a tremendous bearing on a person’s health, emotional stability, and enthusiasm for life. The global coronavirus pandemic has brought unimaginable devastation and hardship in all corners of the globe, questioning the existing healthcare services, health policies, and health planning across the developed and developing countries. It has also exposed the lacunae in understanding health, the base of human happiness. The global community needs to gravely ponder the health issues we are facing and explore sustainable solutions for health recovery and the wellbeing of humanity.
    Type of Medium: Online Resource
    Pages: XVI, 333 p. 65 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811972300
    Series Statement: Advances in Geographical and Environmental Sciences,
    DDC: 304.2
    Language: English
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  • 5
    Call number: SR 90.1035(403)
    In: Circular
    Type of Medium: Series available for loan
    Pages: 55 S.
    Series Statement: Circular / Illinois State Geological Survey 403
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 6
    Monograph available for loan
    Monograph available for loan
    New York : Harper
    Call number: G 5393
    Type of Medium: Monograph available for loan
    Pages: XVII, 692 S. : Ill., graph. Darst., Kt. + 1 Kt.-Beil
    Series Statement: Harper's geoscience series
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 7
    Publication Date: 2017-10-06
    Description: Mycobacterium tuberculosis (Mtb) resistance towards anti-tuberculosis drugs is a widespread problem. Pyrazinamide (PZA) is a first line antitubercular drug that kills semi-dormant bacilli when converted into its activated form i.e. pyrazinoic acid (POA) by Pyrazinamidase (PZase) enzyme coded by pnc A gene. In this study, we conducted several analyses on native and mutant structures (W68R, W68G) of PZase before and after docking with the PZA drug to explore the molecular mechanism behind PZA resistance caused due to pnc A mutations. Structural changes caused by mutations were studied with respect to their effects on functionality of protein. Docking was performed to analyze the protein-drug binding and comparative analysis was done to observe how the mutations affect drug binding affinity and binding site on protein. Native PZase protein was observed to have the maximum binding affinity in terms of docking score as well as shape complementarity in comparison to the mutant forms. Molecular dynamics simulation analyses showed that mutation in the 68 th residue of protein results in a structural change at its active site which further affects the biological function of protein i.e. conversion of PZA to POA. Mutations in the protein thereby led to PZA resistance in the bacterium due to the inefficient binding. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 8
    Publication Date: 2017-05-10
    Description: Evolution of drug resistant Mycobacterium strains threatens the TB treatment and control programs globally. Rifampicin (RIF) is an important first line antitubercular drug. Resistance to Rifampicin is caused mainly by mutations in its target RNA polymerase beta subunit protein (RpoB). RpoB contains a Rifampicin resistance determining region (RRDR) and has several potent sites for mutations. In this study, we have investigated mutations of a single site (H451) to eight different amino acids, involved in RIF resistance. Long term molecular dynamics simulations were performed on wild type (WT) and mutant protein structures and various structural analysis were carried out to elucidate the dynamic behaviour of WT and mutant forms. Essential dynamics uncovered the difference in conformational flexibility and collective modes of motions between WT and mutants. MMPBSA calculations and interaction pattern analysis revealed the binding site relocation in some mutants. This study presents an exhaustive analysis of RIF binding to the WT and mutant RpoB and clearly highlights structural mechanism for differences in stable binding of Rifampicin with WT than the mutant targets. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 9
    Publication Date: 2017-03-02
    Description: Fluoroquinolones are among the most important classes of highly effective antibacterial drugs, exhibiting wide range of activity to cure infectious diseases. Ofloxacin is second generation fluoroquinolone approved by FDA for the treatment of tuberculosis by selectively inhibiting DNA gyrase. However, the emergence of drug resistance owing to mutations in DNA gyrase poses intimidating challenge for the effective therapy of this drug. The double mutants GyrA A90V GyrB D500N and GyrA A90V GyrB T539N arereported to be implicated in conferring higher levels of OFX resistance. The present study was designed to unravel the molecular principles behind development of resistance by the bug against fluoroquinolones. Our results highlighted that polar interactions play critical role in the development of drug resistance and highlight the significant correlation between the free energy calculations predicted by MM-PBSA and stability of the ligand-bound complexes. Modifications at the OFX binding pocket due to amino acid substitution leads to fewer hydrogen bonds in mutants DNA gyrase-OFX complex, which determined the low susceptibility of the ligand in inhibiting the mutant protein. Thisstudy provides a structural rationale to the mutation-based resistance to ofloxacin and will pave way for development potent fluoroquinolone-based resistant-defiant drugs. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 10
    Publication Date: 2014-02-25
    Print ISSN: 1610-2940
    Electronic ISSN: 0948-5023
    Topics: Chemistry and Pharmacology
    Published by Springer
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