ALBERT

Description: Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above 6 x 10(19) electron volts and the positions of active galactic nuclei (AGN) lying within approximately 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest-energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pierre Auger Collaboration -- Abraham, J -- Abreu, P -- Aglietta, M -- Aguirre, C -- Allard, D -- Allekotte, I -- Allen, J -- Allison, P -- Alvarez, C -- Alvarez-Muniz, J -- Ambrosio, M -- Anchordoqui, L -- Andringa, S -- Anzalone, A -- Aramo, C -- Argiro, S -- Arisaka, K -- Armengaud, E -- Arneodo, F -- Arqueros, F -- Asch, T -- Asorey, H -- Assis, P -- Atulugama, B S -- Aublin, J -- Ave, M -- Avila, G -- Backer, T -- Badagnani, D -- Barbosa, A F -- Barnhill, D -- Barroso, S L C -- Bauleo, P -- Beatty, J -- Beau, T -- Becker, B R -- Becker, K H -- Bellido, J A -- Benzvi, S -- Berat, C -- Bergmann, T -- Bernardini, P -- Bertou, X -- Biermann, P L -- Billoir, P -- Blanch-Bigas, O -- Blanco, F -- Blasi, P -- Bleve, C -- Blumer, H -- Bohacova, M -- Bonifazi, C -- Bonino, R -- Boratav, M -- Brack, J -- Brogueira, P -- Brown, W C -- Buchholz, P -- Bueno, A -- Busca, N G -- Caballero-Mora, K S -- Cai, B -- Camin, D V -- Caruso, R -- Carvalho, W -- Castellina, A -- Catalano, O -- Cataldi, G -- Cazon-Boado, L -- Cester, R -- Chauvin, J -- Chiavassa, A -- Chinellato, J A -- Chou, A -- Chye, J -- Clark, P D J -- Clay, R W -- Colombo, E -- Conceicao, R -- Connolly, B -- Contreras, F -- Coppens, J -- Cordier, A -- Cotti, U -- Coutu, S -- Covault, C E -- Creusot, A -- Cronin, J -- Dagoret-Campagne, S -- Daumiller, K -- Dawson, B R -- de Almeida, R M -- De Donato, C -- de Jong, S J -- De La Vega, G -- de Mello Junior, W J M -- de Mello Neto, J R T -- De Mitri, I -- de Souza, V -- Del Peral, L -- Deligny, O -- Selva, A Della -- Fratte, C Delle -- Dembinski, H -- Di Giulio, C -- Diaz, J C -- Dobrigkeit, C -- D'Olivo, J C -- Dornic, D -- Dorofeev, A -- Dos Anjos, J C -- Dova, M T -- D'Urso, D -- Duvernois, M A -- Engel, R -- Epele, L -- Erdmann, M -- Escobar, C O -- Etchegoyen, A -- Facal San Luis, P -- Falcke, H -- Farrar, G -- Fauth, A C -- Fazzini, N -- Fernandez, A -- Ferrer, F -- Ferry, S -- Fick, B -- Filevich, A -- Filipcic, A -- Fleck, I -- Fonte, R -- Fracchiolla, C E -- Fulgione, W -- Garcia, B -- Garcia Gamez, D -- Garcia-Pinto, D -- Garrido, X -- Geenen, H -- Gelmini, G -- Gemmeke, H -- Ghia, P L -- Giller, M -- Glass, H -- Gold, M S -- Golup, G -- Albarracin, F Gomez -- Berisso, M Gomez -- Herrero, R Gomez -- Goncalves, P -- Goncalves do Amaral, M -- Gonzalez, D -- Gonzalez, J G -- Gonzalez, M -- Gora, D -- Gorgi, A -- Gouffon, P -- Grassi, V -- Grillo, A -- Grunfeld, C -- Guardincerri, Y -- Guarino, F -- Guedes, G P -- Gutierrez, J -- Hague, J D -- Hamilton, J C -- Hansen, P -- Harari, D -- Harmsma, S -- Harton, J L -- Haungs, A -- Hauschildt, T -- Healy, M D -- Hebbeker, T -- Heck, D -- Hojvat, C -- Holmes, V C -- Homola, P -- Horandel, J -- Horneffer, A -- Horvat, M -- Hrabovsky, M -- Huege, T -- Iarlori, M -- Insolia, A -- Ionita, F -- Italiano, A -- Kaducak, M -- Kampert, K H -- Keilhauer, B -- Kemp, E -- Kieckhafer, R M -- Klages, H O -- Kleifges, M -- Kleinfeller, J -- Knapik, R -- Knapp, J -- Koang, D-H -- Kopmann, A -- Krieger, A -- Kromer, O -- Kumpel, D -- Kunka, N -- Kusenko, A -- La Rosa, G -- Lachaud, C -- Lago, B L -- Lebrun, D -- Lebrun, P -- Lee, J -- Leigui de Oliveira, M A -- Letessier-Selvon, A -- Leuthold, M -- Lhenry-Yvon, I -- Lopez, R -- Lopez Aguera, A -- Lozano Bahilo, J -- Maccarone, M C -- Macolino, C -- Maldera, S -- Malek, M -- Mancarella, G -- Mancenido, M E -- Mandat, D -- Mantsch, P -- Mariazzi, A G -- Maris, I C -- Martello, D -- Martinez, J -- Martinez Bravo, O -- Mathes, H J -- Matthews, J -- Matthews, J A J -- Matthiae, G -- Maurizio, D -- Mazur, P O -- McCauley, T -- McEwen, M -- McNeil, R R -- Medina, M C -- Medina-Tanco, G -- Meli, A -- Melo, D -- Menichetti, E -- Menschikov, A -- Meurer, Chr -- Meyhandan, R -- Micheletti, M I -- Miele, G -- Miller, W -- Mollerach, S -- Monasor, M -- Monnier Ragaigne, D -- Montanet, F -- Morales, B -- Morello, C -- Moreno, E -- Moreno, J C -- Morris, C -- Mostafa, M -- Muller, M A -- Mussa, R -- Navarra, G -- Navarro, J L -- Navas, S -- Nellen, L -- Newman-Holmes, C -- Newton, D -- Thi, T Nguyen -- Nierstenhofer, N -- Nitz, D -- Nosek, D -- Nozka, L -- Oehlschlager, J -- Ohnuki, T -- Olinto, A -- Olmos-Gilbaja, V M -- Ortiz, M -- Ostapchenko, S -- Otero, L -- Pakk Selmi-Dei, D -- Palatka, M -- Pallotta, J -- Parente, G -- Parizot, E -- Parlati, S -- Pastor, S -- Patel, M -- Paul, T -- Pavlidou, V -- Payet, K -- Pech, M -- Pekala, J -- Pelayo, R -- Pepe, I M -- Perrone, L -- Petrera, S -- Petrinca, P -- Petrov, Y -- Ngoc, Dieppham -- Ngoc, Dongpham -- Pham Thi, T N -- Pichel, A -- Piegaia, R -- Pierog, T -- Pimenta, M -- Pinto, T -- Pirronello, V -- Pisanti, O -- Platino, M -- Pochon, J -- Porter, T A -- Privitera, P -- Prouza, M -- Quel, E J -- Rautenberg, J -- Reucroft, S -- Revenu, B -- Rezende, F A S -- Ridky, J -- Riggi, S -- Risse, M -- Riviere, C -- Rizi, V -- Roberts, M -- Robledo, C -- Rodriguez, G -- Rodriguez Frias, D -- Rodriguez Martino, J -- Rodriguez Rojo, J -- Rodriguez-Cabo, I -- Ros, G -- Rosado, J -- Roth, M -- Rouille-d'Orfeuil, B -- Roulet, E -- Rovero, A C -- Salamida, F -- Salazar, H -- Salina, G -- Sanchez, F -- Santander, M -- Santo, C E -- Santos, E M -- Sarazin, F -- Sarkar, S -- Sato, R -- Scherini, V -- Schieler, H -- Schmidt, F -- Schmidt, T -- Scholten, O -- Schovanek, P -- Schussler, F -- Sciutto, S J -- Scuderi, M -- Segreto, A -- Semikoz, D -- Settimo, M -- Shellard, R C -- Sidelnik, I -- Siffert, B B -- Sigl, G -- De Grande, N Smetniansky -- Smialkowski, A -- Smida, R -- Smith, A G K -- Smith, B E -- Snow, G R -- Sokolsky, P -- Sommers, P -- Sorokin, J -- Spinka, H -- Squartini, R -- Strazzeri, E -- Stutz, A -- Suarez, F -- Suomijarvi, T -- Supanitsky, A D -- Sutherland, M S -- Swain, J -- Szadkowski, Z -- Takahashi, J -- Tamashiro, A -- Tamburro, A -- Tascau, O -- Tcaciuc, R -- Thomas, D -- Ticona, R -- Tiffenberg, J -- Timmermans, C -- Tkaczyk, W -- Todero Peixoto, C J -- Tome, B -- Tonachini, A -- Torresi, D -- Travnicek, P -- Tripathi, A -- Tristram, G -- Tscherniakhovski, D -- Tueros, M -- Tunnicliffe, V -- Ulrich, R -- Unger, M -- Urban, M -- Valdes Galicia, J F -- Valino, I -- Valore, L -- van den Berg, A M -- van Elewyck, V -- Vazquez, R A -- Veberic, D -- Veiga, A -- Velarde, A -- Venters, T -- Verzi, V -- Videla, M -- Villasenor, L -- Vorobiov, S -- Voyvodic, L -- Wahlberg, H -- Wainberg, O -- Waldenmaier, T -- Walker, P -- Warner, D -- Watson, A A -- Westerhoff, S -- Wieczorek, G -- Wiencke, L -- Wilczynska, B -- Wilczynski, H -- Wileman, C -- Winnick, M G -- Wu, H -- Wundheiler, B -- Xu, J -- Yamamoto, T -- Younk, P -- Zas, E -- Zavrtanik, D -- Zavrtanik, M -- Zech, A -- Zepeda, A -- Ziolkowski, M -- Kegl, B -- New York, N.Y. -- Science. 2007 Nov 9;318(5852):938-43.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17991855" target="_blank"〉PubMed〈/a〉

Description: Ion imaging reveals distinct photodissociation dynamics for propanal cations initially prepared in either the cis or gauche conformation, even though these isomers differ only slightly in energy and face a small interconversion barrier. The product kinetic energy distributions for the hydrogen atom elimination channels are bimodal, and the two peaks are readily assigned to propanoyl cation or hydroxyallyl cation coproducts. Ab initio multiple spawning dynamical calculations suggest that distinct ultrafast dynamics in the excited state deposit each conformer in isolated regions of the ground-state potential energy surface, and, from these distinct regions, conformer interconversion does not effectively compete with dissociation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Myung Hwa -- Shen, Lei -- Tao, Hongli -- Martinez, Todd J -- Suits, Arthur G -- New York, N.Y. -- Science. 2007 Mar 16;315(5818):1561-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17363670" target="_blank"〉PubMed〈/a〉

Description: Splicing of mammalian precursor transfer RNA (tRNA) molecules involves two enzymatic steps. First, intron removal by the tRNA splicing endonuclease generates separate 5' and 3' exons. In animals, the second step predominantly entails direct exon ligation by an elusive RNA ligase. Using activity-guided purification of tRNA ligase from HeLa cell extracts, we identified HSPC117, a member of the UPF0027 (RtcB) family, as the essential subunit of a tRNA ligase complex. RNA interference-mediated depletion of HSPC117 inhibited maturation of intron-containing pre-tRNA both in vitro and in living cells. The high sequence conservation of HSPC117/RtcB proteins is suggestive of RNA ligase roles of this protein family in various organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popow, Johannes -- Englert, Markus -- Weitzer, Stefan -- Schleiffer, Alexander -- Mierzwa, Beata -- Mechtler, Karl -- Trowitzsch, Simon -- Will, Cindy L -- Luhrmann, Reinhard -- Soll, Dieter -- Martinez, Javier -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):760-4. doi: 10.1126/science.1197847.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), A-1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21311021" target="_blank"〉PubMed〈/a〉

Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621126/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621126/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez, Gustavo J -- Rao, Anjana -- R01 CA042471/CA/NCI NIH HHS/ -- R01 CA42471/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):891-2. doi: 10.1126/science.1231310.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23161983" target="_blank"〉PubMed〈/a〉

Description: Stable isotope ratios of H, C, and O are powerful indicators of a wide variety of planetary geophysical processes, and for Mars they reveal the record of loss of its atmosphere and subsequent interactions with its surface such as carbonate formation. We report in situ measurements of the isotopic ratios of D/H and (18)O/(16)O in water and (13)C/(12)C, (18)O/(16)O, (17)O/(16)O, and (13)C(18)O/(12)C(16)O in carbon dioxide, made in the martian atmosphere at Gale Crater from the Curiosity rover using the Sample Analysis at Mars (SAM)'s tunable laser spectrometer (TLS). Comparison between our measurements in the modern atmosphere and those of martian meteorites such as ALH 84001 implies that the martian reservoirs of CO2 and H2O were largely established ~4 billion years ago, but that atmospheric loss or surface interaction may be still ongoing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Webster, Chris R -- Mahaffy, Paul R -- Flesch, Gregory J -- Niles, Paul B -- Jones, John H -- Leshin, Laurie A -- Atreya, Sushil K -- Stern, Jennifer C -- Christensen, Lance E -- Owen, Tobias -- Franz, Heather -- Pepin, Robert O -- Steele, Andrew -- MSL Science Team -- Achilles, Cherie -- Agard, Christophe -- Alves Verdasca, Jose Alexandre -- Anderson, Robert -- Anderson, Ryan -- Archer, Doug -- Armiens-Aparicio, Carlos -- Arvidson, Ray -- Atlaskin, Evgeny -- Aubrey, Andrew -- Baker, Burt -- Baker, Michael -- Balic-Zunic, Tonci -- Baratoux, David -- Baroukh, Julien -- Barraclough, Bruce -- Bean, Keri -- Beegle, Luther -- Behar, Alberto -- Bell, James -- Bender, Steve -- Benna, Mehdi -- Bentz, Jennifer -- Berger, Gilles -- Berger, Jeff -- Berman, Daniel -- Bish, David -- Blake, David F -- Blanco Avalos, Juan J -- Blaney, Diana -- Blank, Jen -- Blau, Hannah -- Bleacher, Lora -- Boehm, Eckart -- Botta, Oliver -- Bottcher, Stephan -- Boucher, Thomas -- Bower, Hannah -- Boyd, Nick -- Boynton, Bill -- Breves, Elly -- Bridges, John -- Bridges, Nathan -- Brinckerhoff, William -- Brinza, David -- Bristow, Thomas -- Brunet, Claude -- Brunner, Anna -- Brunner, Will -- Buch, Arnaud -- Bullock, Mark -- Burmeister, Sonke -- Cabane, Michel -- Calef, Fred -- Cameron, James -- Campbell, John -- Cantor, Bruce -- Caplinger, Michael -- Caride Rodriguez, Javier -- Carmosino, Marco -- Carrasco Blazquez, Isaias -- Charpentier, Antoine -- Chipera, Steve -- Choi, David -- Clark, Benton -- Clegg, Sam -- Cleghorn, Timothy -- Cloutis, Ed -- Cody, George -- Coll, Patrice -- Conrad, Pamela -- Coscia, David -- Cousin, Agnes -- Cremers, David -- Crisp, Joy -- Cros, Alain -- Cucinotta, Frank -- d'Uston, Claude -- Davis, Scott -- Day, Mackenzie -- de la Torre Juarez, Manuel -- DeFlores, Lauren -- DeLapp, Dorothea -- DeMarines, Julia -- DesMarais, David -- Dietrich, William -- Dingler, Robert -- Donny, Christophe -- Downs, Bob -- Drake, Darrell -- Dromart, Gilles -- Dupont, Audrey -- Duston, Brian -- Dworkin, Jason -- Dyar, M Darby -- Edgar, Lauren -- Edgett, Kenneth -- Edwards, Christopher -- Edwards, Laurence -- Ehlmann, Bethany -- Ehresmann, Bent -- Eigenbrode, Jen -- Elliott, Beverley -- Elliott, Harvey -- Ewing, Ryan -- Fabre, Cecile -- Fairen, Alberto -- Farley, Ken -- Farmer, Jack -- Fassett, Caleb -- Favot, Laurent -- Fay, Donald -- Fedosov, Fedor -- Feldman, Jason -- Feldman, Sabrina -- Fisk, Marty -- Fitzgibbon, Mike -- Floyd, Melissa -- Fluckiger, Lorenzo -- Forni, Olivier -- Fraeman, Abby -- Francis, Raymond -- Francois, Pascaline -- Freissinet, Caroline -- French, Katherine Louise -- Frydenvang, Jens -- Gaboriaud, Alain -- Gailhanou, Marc -- Garvin, James -- Gasnault, Olivier -- Geffroy, Claude -- Gellert, Ralf -- Genzer, Maria -- Glavin, Daniel -- Godber, Austin -- Goesmann, Fred -- Goetz, Walter -- Golovin, Dmitry -- Gomez Gomez, Felipe -- Gomez-Elvira, Javier -- Gondet, Brigitte -- Gordon, Suzanne -- Gorevan, Stephen -- Grant, John -- Griffes, Jennifer -- Grinspoon, David -- Grotzinger, John -- Guillemot, Philippe -- Guo, Jingnan -- Gupta, Sanjeev -- Guzewich, Scott -- Haberle, Robert -- Halleaux, Douglas -- Hallet, Bernard -- Hamilton, Vicky -- Hardgrove, Craig -- Harker, David -- Harpold, Daniel -- Harri, Ari-Matti -- Harshman, Karl -- Hassler, Donald -- Haukka, Harri -- Hayes, Alex -- Herkenhoff, Ken -- Herrera, Paul -- Hettrich, Sebastian -- Heydari, Ezat -- Hipkin, Victoria -- Hoehler, Tori -- Hollingsworth, Jeff -- Hudgins, Judy -- Huntress, Wesley -- Hurowitz, Joel -- Hviid, Stubbe -- Iagnemma, Karl -- Indyk, Steve -- Israel, Guy -- Jackson, Ryan -- Jacob, Samantha -- Jakosky, Bruce -- Jensen, Elsa -- Jensen, Jaqueline Klovgaard -- Johnson, Jeffrey -- Johnson, Micah -- Johnstone, Steve -- Jones, Andrea -- Joseph, Jonathan -- Jun, Insoo -- Kah, Linda -- Kahanpaa, Henrik -- Kahre, Melinda -- Karpushkina, Natalya -- Kasprzak, Wayne -- Kauhanen, Janne -- Keely, Leslie -- Kemppinen, Osku -- Keymeulen, Didier -- Kim, Myung-Hee -- Kinch, Kjartan -- King, Penny -- Kirkland, Laurel -- Kocurek, Gary -- Koefoed, Asmus -- Kohler, Jan -- Kortmann, Onno -- Kozyrev, Alexander -- Krezoski, Jill -- Krysak, Daniel -- Kuzmin, Ruslan -- Lacour, Jean Luc -- Lafaille, Vivian -- Langevin, Yves -- Lanza, Nina -- Lasue, Jeremie -- Le Mouelic, Stephane -- Lee, Ella Mae -- Lee, Qiu-Mei -- Lees, David -- Lefavor, Matthew -- Lemmon, Mark -- Lepinette Malvitte, Alain -- Leveille, Richard -- Lewin-Carpintier, Eric -- Lewis, Kevin -- Li, Shuai -- Lipkaman, Leslie -- Little, Cynthia -- Litvak, Maxim -- Lorigny, Eric -- Lugmair, Guenter -- Lundberg, Angela -- Lyness, Eric -- Madsen, Morten -- Maki, Justin -- Malakhov, Alexey -- Malespin, Charles -- Malin, Michael -- Mangold, Nicolas -- Manhes, Gerard -- Manning, Heidi -- Marchand, Genevieve -- Marin Jimenez, Mercedes -- Martin Garcia, Cesar -- Martin, Dave -- Martin, Mildred -- Martinez-Frias, Jesus -- Martin-Soler, Javier -- Martin-Torres, F Javier -- Mauchien, Patrick -- Maurice, Sylvestre -- McAdam, Amy -- McCartney, Elaina -- McConnochie, Timothy -- McCullough, Emily -- McEwan, Ian -- McKay, Christopher -- McLennan, Scott -- McNair, Sean -- Melikechi, Noureddine -- Meslin, Pierre-Yves -- Meyer, Michael -- Mezzacappa, Alissa -- Miller, Hayden -- Miller, Kristen -- Milliken, Ralph -- Ming, Douglas -- Minitti, Michelle -- Mischna, Michael -- Mitrofanov, Igor -- Moersch, Jeff -- Mokrousov, Maxim -- Molina Jurado, Antonio -- Moores, John -- Mora-Sotomayor, Luis -- Morookian, John Michael -- Morris, Richard -- Morrison, Shaunna -- Mueller-Mellin, Reinhold -- Muller, Jan-Peter -- Munoz Caro, Guillermo -- Nachon, Marion -- Navarro Lopez, Sara -- Navarro-Gonzalez, Rafael -- Nealson, Kenneth -- Nefian, Ara -- Nelson, Tony -- Newcombe, Megan -- Newman, Claire -- Newsom, Horton -- Nikiforov, Sergey -- Nixon, Brian -- Noe Dobrea, Eldar -- Nolan, Thomas -- Oehler, Dorothy -- Ollila, Ann -- Olson, Timothy -- de Pablo Hernandez, Miguel Angel -- Paillet, Alexis -- Pallier, Etienne -- Palucis, Marisa -- Parker, Timothy -- Parot, Yann -- Patel, Kiran -- Paton, Mark -- Paulsen, Gale -- Pavlov, Alex -- Pavri, Betina -- Peinado-Gonzalez, Veronica -- Peret, Laurent -- Perez, Rene -- Perrett, Glynis -- Peterson, Joe -- Pilorget, Cedric -- Pinet, Patrick -- Pla-Garcia, Jorge -- Plante, Ianik -- Poitrasson, Franck -- Polkko, Jouni -- Popa, Radu -- Posiolova, Liliya -- Posner, Arik -- Pradler, Irina -- Prats, Benito -- Prokhorov, Vasily -- Purdy, Sharon Wilson -- Raaen, Eric -- Radziemski, Leon -- Rafkin, Scot -- Ramos, Miguel -- Rampe, Elizabeth -- Raulin, Francois -- Ravine, Michael -- Reitz, Gunther -- Renno, Nilton -- Rice, Melissa -- Richardson, Mark -- Robert, Francois -- Robertson, Kevin -- Rodriguez Manfredi, Jose Antonio -- Romeral-Planello, Julio J -- Rowland, Scott -- Rubin, David -- Saccoccio, Muriel -- Salamon, Andrew -- Sandoval, Jennifer -- Sanin, Anton -- Sans Fuentes, Sara Alejandra -- Saper, Lee -- Sarrazin, Philippe -- Sautter, Violaine -- Savijarvi, Hannu -- Schieber, Juergen -- Schmidt, Mariek -- Schmidt, Walter -- Scholes, Daniel -- Schoppers, Marcel -- Schroder, Susanne -- Schwenzer, Susanne -- Sebastian Martinez, Eduardo -- Sengstacken, Aaron -- Shterts, Ruslan -- Siebach, Kirsten -- Siili, Tero -- Simmonds, Jeff -- Sirven, Jean-Baptiste -- Slavney, Susie -- Sletten, Ronald -- Smith, Michael -- Sobron Sanchez, Pablo -- Spanovich, Nicole -- Spray, John -- Squyres, Steven -- Stack, Katie -- Stalport, Fabien -- Stein, Thomas -- Stewart, Noel -- Stipp, Susan Louise Svane -- Stoiber, Kevin -- Stolper, Ed -- Sucharski, Bob -- Sullivan, Rob -- Summons, Roger -- Sumner, Dawn -- Sun, Vivian -- Supulver, Kimberley -- Sutter, Brad -- Szopa, Cyril -- Tan, Florence -- Tate, Christopher -- Teinturier, Samuel -- ten Kate, Inge -- Thomas, Peter -- Thompson, Lucy -- Tokar, Robert -- Toplis, Mike -- Torres Redondo, Josefina -- Trainer, Melissa -- Treiman, Allan -- Tretyakov, Vladislav -- Urqui-O'Callaghan, Roser -- Van Beek, Jason -- Van Beek, Tessa -- VanBommel, Scott -- Vaniman, David -- Varenikov, Alexey -- Vasavada, Ashwin -- Vasconcelos, Paulo -- Vicenzi, Edward -- Vostrukhin, Andrey -- Voytek, Mary -- Wadhwa, Meenakshi -- Ward, Jennifer -- Weigle, Eddie -- Wellington, Danika -- Westall, Frances -- Wiens, Roger Craig -- Wilhelm, Mary Beth -- Williams, Amy -- Williams, Joshua -- Williams, Rebecca -- Williams, Richard B -- Wilson, Mike -- Wimmer-Schweingruber, Robert -- Wolff, Mike -- Wong, Mike -- Wray, James -- Wu, Megan -- Yana, Charles -- Yen, Albert -- Yingst, Aileen -- Zeitlin, Cary -- Zimdar, Robert -- Zorzano Mier, Maria-Paz -- New York, N.Y. -- Science. 2013 Jul 19;341(6143):260-3. doi: 10.1126/science.1237961.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. chris.r.webster@jpl.nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23869013" target="_blank"〉PubMed〈/a〉

Description: The regioselectivity of deprotonation reactions between arene substrates and basic metalating agents is usually governed by the electronic and/or coordinative characteristics of a directing group attached to the benzene ring. Generally, the reaction takes place in the ortho position, adjacent to the substituent. Here, we introduce a protocol by which the metalating agent, a disodium-monomagnesium alkyl-amide, forms a template that extends regioselectivity to more distant arene sites. Depending on the nature of the directing group, ortho-meta' or meta-meta' dimetalation is observed, in the latter case breaking the dogma of ortho metalation. This concept is elaborated through the characterization of both organometallic intermediates and electrophilically quenched products.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez-Martinez, Antonio J -- Kennedy, Alan R -- Mulvey, Robert E -- O'Hara, Charles T -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):834-7. doi: 10.1126/science.1259662.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. ; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. r.e.mulvey@strath.ac.uk charlie.ohara@strath.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395533" target="_blank"〉PubMed〈/a〉

Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alatalo, R V -- Aragon, S -- Aviles, J M -- Barbosa, A -- Gomes, C Bessa -- Cadee, N -- Christe, P -- Cuervo, J J -- Diaz, M -- Erritzoe, J -- Galeotti, P -- Garamszegi, L Z -- Gil, D -- Gontard-Danek, M -- Legendre, S -- Martin, T E -- Martinez, J -- Martin-Vivaldi, M -- Martinez, J G -- Merino, S -- Moreno, J -- Mousseau, Tim -- Ninni, P -- Petrie, M -- Pulido, F -- Rubolini, D -- Saino, N -- Soler, J J -- Soler, M -- Spottiswoode, C -- Szep, T -- Thornhill, R -- Zamora, C -- Sacchi, Roberto -- New York, N.Y. -- Science. 2004 Mar 12;303(5664):1612.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15016981" target="_blank"〉PubMed〈/a〉

Description: The large-scale distribution of galaxies and galaxy clusters in the universe can be described in the mathematical language of multifractal sets. A particularly significant aspect of this description is that it furnishes a natural explanation for the observed differences in clustering properties of objects of different density in terms of multiscaling, the generic consequence of the application of a local density threshold to a multifractal set. The multiscaling hypothesis suggests ways of improving upon the traditional statistical measures of clustering pattern (correlation functions) and exploring further the connection between clustering pattern and dynamics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez, V J -- Paredes, S -- Borgani, S -- Coles, P -- New York, N.Y. -- Science. 1995 Sep 1;269(5228):1245-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17732110" target="_blank"〉PubMed〈/a〉

Description: Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1991296/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1991296/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fellay, Jacques -- Shianna, Kevin V -- Ge, Dongliang -- Colombo, Sara -- Ledergerber, Bruno -- Weale, Mike -- Zhang, Kunlin -- Gumbs, Curtis -- Castagna, Antonella -- Cossarizza, Andrea -- Cozzi-Lepri, Alessandro -- De Luca, Andrea -- Easterbrook, Philippa -- Francioli, Patrick -- Mallal, Simon -- Martinez-Picado, Javier -- Miro, Jose M -- Obel, Niels -- Smith, Jason P -- Wyniger, Josiane -- Descombes, Patrick -- Antonarakis, Stylianos E -- Letvin, Norman L -- McMichael, Andrew J -- Haynes, Barton F -- Telenti, Amalio -- Goldstein, David B -- G0200585/Medical Research Council/United Kingdom -- MC_U137884177/Medical Research Council/United Kingdom -- U19 AI067854/AI/NIAID NIH HHS/ -- U19 AI067854-03/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2007 Aug 17;317(5840):944-7. Epub 2007 Jul 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17641165" target="_blank"〉PubMed〈/a〉

Description: A fundamental function of CD4+ helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH) cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced T(FH)-related gene expression and inhibited other T(H) lineage cell differentiation in a DNA binding-dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired T(FH) cell development and germinal center reactions, and altered production of other effector T cell subsets. Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857334/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857334/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nurieva, Roza I -- Chung, Yeonseok -- Martinez, Gustavo J -- Yang, Xuexian O -- Tanaka, Shinya -- Matskevitch, Tatyana D -- Wang, Yi-Hong -- Dong, Chen -- R01 AI050746/AI/NIAID NIH HHS/ -- R01 AI050746-05/AI/NIAID NIH HHS/ -- R01 AI050761/AI/NIAID NIH HHS/ -- R01 AI050761-05/AI/NIAID NIH HHS/ -- R01 AI050761-06/AI/NIAID NIH HHS/ -- R01 AI050761-07A1/AI/NIAID NIH HHS/ -- R01 AI083761/AI/NIAID NIH HHS/ -- R01 AR050772/AR/NIAMS NIH HHS/ -- R01 AR050772-07/AR/NIAMS NIH HHS/ -- R01 AR050772-08/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 21;325(5943):1001-5. doi: 10.1126/science.1176676. Epub 2009 Jul 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA. rnurieva@mdanderson.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19628815" target="_blank"〉PubMed〈/a〉