Publication Date:
2009-07-25
Description:
A fundamental function of CD4+ helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH) cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced T(FH)-related gene expression and inhibited other T(H) lineage cell differentiation in a DNA binding-dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired T(FH) cell development and germinal center reactions, and altered production of other effector T cell subsets. Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857334/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857334/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nurieva, Roza I -- Chung, Yeonseok -- Martinez, Gustavo J -- Yang, Xuexian O -- Tanaka, Shinya -- Matskevitch, Tatyana D -- Wang, Yi-Hong -- Dong, Chen -- R01 AI050746/AI/NIAID NIH HHS/ -- R01 AI050746-05/AI/NIAID NIH HHS/ -- R01 AI050761/AI/NIAID NIH HHS/ -- R01 AI050761-05/AI/NIAID NIH HHS/ -- R01 AI050761-06/AI/NIAID NIH HHS/ -- R01 AI050761-07A1/AI/NIAID NIH HHS/ -- R01 AI083761/AI/NIAID NIH HHS/ -- R01 AR050772/AR/NIAMS NIH HHS/ -- R01 AR050772-07/AR/NIAMS NIH HHS/ -- R01 AR050772-08/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 21;325(5943):1001-5. doi: 10.1126/science.1176676. Epub 2009 Jul 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA. rnurieva@mdanderson.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19628815" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibody Formation
;
B-Lymphocytes/immunology
;
Cell Differentiation
;
Cell Lineage
;
Cytokines/immunology/metabolism
;
DNA-Binding Proteins/deficiency/genetics/*metabolism
;
Germinal Center/cytology/*immunology
;
Immunoglobulins/biosynthesis
;
Interleukin-6/immunology/metabolism
;
Interleukins/immunology/metabolism
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Mutation
;
RNA, Messenger/genetics/metabolism
;
T-Lymphocyte Subsets/cytology/*immunology
;
T-Lymphocytes, Helper-Inducer/cytology/*immunology
;
Transcription Factors/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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