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  • 1
    Publication Date: 2016-08-10
    Description: Article Combination therapy with α-CTLA-4 and α-PD-1 is showing improved therapeutic effects in clinical trials. Here, the authors report that mechanistically in bladder cancer such effect depends upon an upregulation of T cell activity mediated by the IL-7/IL-7R and IFN-γ/IFN-γR signalling pathways. Nature Communications doi: 10.1038/ncomms12335 Authors: Lewis Zhichang Shi, Tihui Fu, Baoxiang Guan, Jianfeng Chen, Jorge M. Blando, James P. Allison, Liangwen Xiong, Sumit K. Subudhi, Jianjun Gao, Padmanee Sharma
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
    Publication Date: 2012-11-08
    Description: Author(s): P. W. Gorham, A. Connolly, P. Allison, J. J. Beatty, K. Belov, D. Z. Besson, W. R. Binns, P. Chen, J. M. Clem, S. Hoover, M. H. Israel, J. Nam, D. Saltzberg, G. S. Varner, and A. G. Vieregg We consider the implications of Lorentz-invariance violation (LIV) on cosmogenic neutrino observations, with particular focus on the constraints imposed on several well-developed models for ultrahigh energy cosmogenic neutrino production by recent results from the ANITA long-duration balloon payload... [Phys. Rev. D 86, 103006] Published Wed Nov 07, 2012
    Keywords: Astrophysics & Cosmology
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 3
    Publication Date: 2013-02-08
    Description: Langmuir DOI: 10.1021/la3042204
    Print ISSN: 0743-7463
    Electronic ISSN: 1520-5827
    Topics: Chemistry and Pharmacology
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  • 4
    Publication Date: 2014-10-08
    Description: We describe herein a measurement of the Antarctic surface “roughness” performed by the balloon-borne ANITA (ANtarctic Impulsive Transient Antenna) experiment. Originally purposed for cosmic-ray astrophysics, the radio-frequency (RF) receiver ANITA gondola, from its 38 km altitude vantage point, can scan a disk of snow surface 600 km in radius. The primary purpose of ANITA is to detect RF emissions from cosmic rays incident on Antarctica, such as neutrinos which penetrate through the atmosphere and interact within the ice, resulting in signal directed upwards which then refracts at the ice-air interface and up and out to ANITA, or high-energy nuclei (most likely irons or protons), which interact in the upper atmosphere (at altitudes below ANITA) and produce a spray of down-coming RF which reflects off the snow surface and back up to the gondola. The energy of such high-energy nuclei can be inferred from the observed reflectedsignal only if the surface reflectivity is known. We describe herein an attempt to quantify the Antarctic surface reflectivity, using the Sun as a constant, unpolarized RF source. We find that the reflectivity of the surface generally follows the expectations from the Fresnel equations, lending support to the use of those equations to give an overall correction factor to calculate cosmic ray energies for all locations in Antarctica. The analysis described below is based on ANITA-II data. After launching from McMurdo Station in December, 2008, ANITA-II was aloft for a period of 31 days with a typical instantaneous duty cycle exceeding 95%.
    Print ISSN: 0048-6604
    Electronic ISSN: 1944-799X
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
    Publication Date: 2014-11-26
    Description: Although major research efforts have focused on how specific components of foodstuffs affect health, relatively little is known about a more fundamental aspect of diet, the frequency and circadian timing of meals, and potential benefits of intermittent periods with no or very low energy intakes. The most common eating pattern...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 6
    Publication Date: 2014-11-12
    Description: Successful progression through the cell cycle requires spatial and temporal regulation of gene transcript levels and the number, positions and condensation levels of chromosomes. Here we present a high resolution survey of genome interactions in Schizosaccharomyces pombe using synchronized cells to investigate cell cycle dependent changes in genome organization and transcription. Cell cycle dependent interactions were captured between and within S. pombe chromosomes. Known features of genome organization (e.g. the clustering of telomeres and retrotransposon long terminal repeats (LTRs)) were observed throughout the cell cycle. There were clear correlations between transcript levels and chromosomal interactions between genes, consistent with a role for interactions in transcriptional regulation at specific stages of the cell cycle. In silico reconstructions of the chromosome organization within the S. pombe nuclei were made by polymer modeling. These models suggest that groups of genes with high and low, or differentially regulated transcript levels have preferred positions within the S. pombe nucleus. We conclude that the S. pombe nucleus is spatially divided into functional sub-nuclear domains that correlate with gene activity. The observation that chromosomal interactions are maintained even when chromosomes are fully condensed in M phase implicates genome organization in epigenetic inheritance and bookmarking.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 7
    Publication Date: 1991-06-07
    Description: Thy-1+ dendritic epidermal T cells (dECs) express invariant gamma delta antigen receptors and are found in intimate contact with keratinocytes in murine epidermis--thus raising the possibility that keratinocytes express a ligand for the antigen receptor of these T cells. Thy-1+ dECs were stimulated to produce lymphokines by interaction with keratinocytes in vitro. This stimulation was mediated through the dEC antigen receptor and did not appear to be restricted by the major histocompatibility complex. Thus, dECs can recognize self antigens and may participate in immune surveillance for cellular damage rather than for foreign antigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Havran, W L -- Chien, Y H -- Allison, J P -- AI26942/AI/NIAID NIH HHS/ -- CA40041/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Jun 7;252(5011):1430-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1828619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantigens/*immunology ; Cell Line ; Dendrites/immunology ; Epidermis ; *Immunity, Cellular ; In Vitro Techniques ; Interleukin-2/secretion ; Keratinocytes/physiology ; Mice ; Mice, Inbred BALB C ; Receptors, Antigen, T-Cell/*physiology ; Receptors, Antigen, T-Cell, gamma-delta ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2007-11-10
    Description: Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above 6 x 10(19) electron volts and the positions of active galactic nuclei (AGN) lying within approximately 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest-energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar spatial distribution are possible sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pierre Auger Collaboration -- Abraham, J -- Abreu, P -- Aglietta, M -- Aguirre, C -- Allard, D -- Allekotte, I -- Allen, J -- Allison, P -- Alvarez, C -- Alvarez-Muniz, J -- Ambrosio, M -- Anchordoqui, L -- Andringa, S -- Anzalone, A -- Aramo, C -- Argiro, S -- Arisaka, K -- Armengaud, E -- Arneodo, F -- Arqueros, F -- Asch, T -- Asorey, H -- Assis, P -- Atulugama, B S -- Aublin, J -- Ave, M -- Avila, G -- Backer, T -- Badagnani, D -- Barbosa, A F -- Barnhill, D -- Barroso, S L C -- Bauleo, P -- Beatty, J -- Beau, T -- Becker, B R -- Becker, K H -- Bellido, J A -- Benzvi, S -- Berat, C -- Bergmann, T -- Bernardini, P -- Bertou, X -- Biermann, P L -- Billoir, P -- Blanch-Bigas, O -- Blanco, F -- Blasi, P -- Bleve, C -- Blumer, H -- Bohacova, M -- Bonifazi, C -- Bonino, R -- Boratav, M -- Brack, J -- Brogueira, P -- Brown, W C -- Buchholz, P -- Bueno, A -- Busca, N G -- Caballero-Mora, K S -- Cai, B -- Camin, D V -- Caruso, R -- Carvalho, W -- Castellina, A -- Catalano, O -- Cataldi, G -- Cazon-Boado, L -- Cester, R -- Chauvin, J -- Chiavassa, A -- Chinellato, J A -- Chou, A -- Chye, J -- Clark, P D J -- Clay, R W -- Colombo, E -- Conceicao, R -- Connolly, B -- Contreras, F -- Coppens, J -- Cordier, A -- Cotti, U -- Coutu, S -- Covault, C E -- Creusot, A -- Cronin, J -- Dagoret-Campagne, S -- Daumiller, K -- Dawson, B R -- de Almeida, R M -- De Donato, C -- de Jong, S J -- De La Vega, G -- de Mello Junior, W J M -- de Mello Neto, J R T -- De Mitri, I -- de Souza, V -- Del Peral, L -- Deligny, O -- Selva, A Della -- Fratte, C Delle -- Dembinski, H -- Di Giulio, C -- Diaz, J C -- Dobrigkeit, C -- D'Olivo, J C -- Dornic, D -- Dorofeev, A -- Dos Anjos, J C -- Dova, M T -- D'Urso, D -- Duvernois, M A -- Engel, R -- Epele, L -- Erdmann, M -- Escobar, C O -- Etchegoyen, A -- Facal San Luis, P -- Falcke, H -- Farrar, G -- Fauth, A C -- Fazzini, N -- Fernandez, A -- Ferrer, F -- Ferry, S -- Fick, B -- Filevich, A -- Filipcic, A -- Fleck, I -- Fonte, R -- Fracchiolla, C E -- Fulgione, W -- Garcia, B -- Garcia Gamez, D -- Garcia-Pinto, D -- Garrido, X -- Geenen, H -- Gelmini, G -- Gemmeke, H -- Ghia, P L -- Giller, M -- Glass, H -- Gold, M S -- Golup, G -- Albarracin, F Gomez -- Berisso, M Gomez -- Herrero, R Gomez -- Goncalves, P -- Goncalves do Amaral, M -- Gonzalez, D -- Gonzalez, J G -- Gonzalez, M -- Gora, D -- Gorgi, A -- Gouffon, P -- Grassi, V -- Grillo, A -- Grunfeld, C -- Guardincerri, Y -- Guarino, F -- Guedes, G P -- Gutierrez, J -- Hague, J D -- Hamilton, J C -- Hansen, P -- Harari, D -- Harmsma, S -- Harton, J L -- Haungs, A -- Hauschildt, T -- Healy, M D -- Hebbeker, T -- Heck, D -- Hojvat, C -- Holmes, V C -- Homola, P -- Horandel, J -- Horneffer, A -- Horvat, M -- Hrabovsky, M -- Huege, T -- Iarlori, M -- Insolia, A -- Ionita, F -- Italiano, A -- Kaducak, M -- Kampert, K H -- Keilhauer, B -- Kemp, E -- Kieckhafer, R M -- Klages, H O -- Kleifges, M -- Kleinfeller, J -- Knapik, R -- Knapp, J -- Koang, D-H -- Kopmann, A -- Krieger, A -- Kromer, O -- Kumpel, D -- Kunka, N -- Kusenko, A -- La Rosa, G -- Lachaud, C -- Lago, B L -- Lebrun, D -- Lebrun, P -- Lee, J -- Leigui de Oliveira, M A -- Letessier-Selvon, A -- Leuthold, M -- Lhenry-Yvon, I -- Lopez, R -- Lopez Aguera, A -- Lozano Bahilo, J -- Maccarone, M C -- Macolino, C -- Maldera, S -- Malek, M -- Mancarella, G -- Mancenido, M E -- Mandat, D -- Mantsch, P -- Mariazzi, A G -- Maris, I C -- Martello, D -- Martinez, J -- Martinez Bravo, O -- Mathes, H J -- Matthews, J -- Matthews, J A J -- Matthiae, G -- Maurizio, D -- Mazur, P O -- McCauley, T -- McEwen, M -- McNeil, R R -- Medina, M C -- Medina-Tanco, G -- Meli, A -- Melo, D -- Menichetti, E -- Menschikov, A -- Meurer, Chr -- Meyhandan, R -- Micheletti, M I -- Miele, G -- Miller, W -- Mollerach, S -- Monasor, M -- Monnier Ragaigne, D -- Montanet, F -- Morales, B -- Morello, C -- Moreno, E -- Moreno, J C -- Morris, C -- Mostafa, M -- Muller, M A -- Mussa, R -- Navarra, G -- Navarro, J L -- Navas, S -- Nellen, L -- Newman-Holmes, C -- Newton, D -- Thi, T Nguyen -- Nierstenhofer, N -- Nitz, D -- Nosek, D -- Nozka, L -- Oehlschlager, J -- Ohnuki, T -- Olinto, A -- Olmos-Gilbaja, V M -- Ortiz, M -- Ostapchenko, S -- Otero, L -- Pakk Selmi-Dei, D -- Palatka, M -- Pallotta, J -- Parente, G -- Parizot, E -- Parlati, S -- Pastor, S -- Patel, M -- Paul, T -- Pavlidou, V -- Payet, K -- Pech, M -- Pekala, J -- Pelayo, R -- Pepe, I M -- Perrone, L -- Petrera, S -- Petrinca, P -- Petrov, Y -- Ngoc, Dieppham -- Ngoc, Dongpham -- Pham Thi, T N -- Pichel, A -- Piegaia, R -- Pierog, T -- Pimenta, M -- Pinto, T -- Pirronello, V -- Pisanti, O -- Platino, M -- Pochon, J -- Porter, T A -- Privitera, P -- Prouza, M -- Quel, E J -- Rautenberg, J -- Reucroft, S -- Revenu, B -- Rezende, F A S -- Ridky, J -- Riggi, S -- Risse, M -- Riviere, C -- Rizi, V -- Roberts, M -- Robledo, C -- Rodriguez, G -- Rodriguez Frias, D -- Rodriguez Martino, J -- Rodriguez Rojo, J -- Rodriguez-Cabo, I -- Ros, G -- Rosado, J -- Roth, M -- Rouille-d'Orfeuil, B -- Roulet, E -- Rovero, A C -- Salamida, F -- Salazar, H -- Salina, G -- Sanchez, F -- Santander, M -- Santo, C E -- Santos, E M -- Sarazin, F -- Sarkar, S -- Sato, R -- Scherini, V -- Schieler, H -- Schmidt, F -- Schmidt, T -- Scholten, O -- Schovanek, P -- Schussler, F -- Sciutto, S J -- Scuderi, M -- Segreto, A -- Semikoz, D -- Settimo, M -- Shellard, R C -- Sidelnik, I -- Siffert, B B -- Sigl, G -- De Grande, N Smetniansky -- Smialkowski, A -- Smida, R -- Smith, A G K -- Smith, B E -- Snow, G R -- Sokolsky, P -- Sommers, P -- Sorokin, J -- Spinka, H -- Squartini, R -- Strazzeri, E -- Stutz, A -- Suarez, F -- Suomijarvi, T -- Supanitsky, A D -- Sutherland, M S -- Swain, J -- Szadkowski, Z -- Takahashi, J -- Tamashiro, A -- Tamburro, A -- Tascau, O -- Tcaciuc, R -- Thomas, D -- Ticona, R -- Tiffenberg, J -- Timmermans, C -- Tkaczyk, W -- Todero Peixoto, C J -- Tome, B -- Tonachini, A -- Torresi, D -- Travnicek, P -- Tripathi, A -- Tristram, G -- Tscherniakhovski, D -- Tueros, M -- Tunnicliffe, V -- Ulrich, R -- Unger, M -- Urban, M -- Valdes Galicia, J F -- Valino, I -- Valore, L -- van den Berg, A M -- van Elewyck, V -- Vazquez, R A -- Veberic, D -- Veiga, A -- Velarde, A -- Venters, T -- Verzi, V -- Videla, M -- Villasenor, L -- Vorobiov, S -- Voyvodic, L -- Wahlberg, H -- Wainberg, O -- Waldenmaier, T -- Walker, P -- Warner, D -- Watson, A A -- Westerhoff, S -- Wieczorek, G -- Wiencke, L -- Wilczynska, B -- Wilczynski, H -- Wileman, C -- Winnick, M G -- Wu, H -- Wundheiler, B -- Xu, J -- Yamamoto, T -- Younk, P -- Zas, E -- Zavrtanik, D -- Zavrtanik, M -- Zech, A -- Zepeda, A -- Ziolkowski, M -- Kegl, B -- New York, N.Y. -- Science. 2007 Nov 9;318(5852):938-43.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17991855" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2016-04-27
    Description: Author(s): P. Allison et al. (The ARA collaboration) Ultrahigh energy neutrinos are interesting messenger particles since, if detected, they can transmit exclusive information about ultrahigh energy processes in the Universe. These particles, with energies above 10 16     eV , interact very rarely. Therefore, detectors that instrument several gigatons of m… [Phys. Rev. D 93, 082003] Published Mon Apr 25, 2016
    Keywords: Gravitational Experiment
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 10
    Publication Date: 2011-11-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allison, James P -- Benoist, Christophe -- Chervonsky, Alexander V -- England -- Nature. 2011 Nov 9;479(7372):178. doi: 10.1038/479178a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22071753" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptive Immunity/immunology ; History, 20th Century ; Immunity, Innate/immunology ; Models, Immunological ; *Nobel Prize ; Toll-Like Receptors/*history/immunology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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