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  • Institute of Physics  (67)
  • Springer  (18)
  • American Association for the Advancement of Science (AAAS)  (17)
  • Nature Publishing Group (NPG)  (10)
  • 1
    Publication Date: 2007
    Description: Electrical microstimulation can establish causal links between the activity of groups of neurons and perceptual and cognitive functions. However, the number and identities of neurons microstimulated, as well as the number of action potentials evoked, are difficult to ascertain. To address these issues we introduced the light-gated algal channel channelrhodopsin-2 (ChR2) specifically into a small fraction of layer 2/3 neurons of the mouse primary somatosensory cortex. ChR2 photostimulation in vivo reliably generated stimulus-locked action potentials at frequencies up to 50 Hz. Here we show that naive mice readily learned to detect brief trains of action potentials (five light pulses, 1 ms, 20 Hz). After training, mice could detect a photostimulus firing a single action potential in approximately 300 neurons. Even fewer neurons (approximately 60) were required for longer stimuli (five action potentials, 250 ms). Our results show that perceptual decisions and learning can be driven by extremely brief epochs of cortical activity in a sparse subset of supragranular cortical pyramidal neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425380/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425380/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, Daniel -- Petreanu, Leopoldo -- Ghitani, Nima -- Ranade, Sachin -- Hromadka, Tomas -- Mainen, Zach -- Svoboda, Karel -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Jan 3;451(7174):61-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18094685" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/physiology/radiation effects ; Algal Proteins/genetics/metabolism ; Animals ; Behavior, Animal/*physiology/*radiation effects ; Cerebral Cortex/cytology/*physiology/*radiation effects ; Electric Stimulation ; Learning/*physiology/radiation effects ; Mice ; Movement/*physiology ; Optics and Photonics ; Photic Stimulation ; Pyramidal Cells/metabolism/radiation effects ; Rhodopsins, Microbial/genetics/metabolism
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  • 2
    Publication Date: 2009-10-16
    Description: Behaviour is governed by activity in highly structured neural circuits. Genetically targeted sensors and switches facilitate measurement and manipulation of activity in vivo, linking activity in defined nodes of neural circuits to behaviour. Because of access to specific cell types, these molecular tools will have the largest impact in genetic model systems such as the mouse. Emerging assays of mouse behaviour are beginning to rival those of behaving monkeys in terms of stimulus and behavioural control. We predict that the confluence of new behavioural and molecular tools in the mouse will reveal the logic of complex mammalian circuits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Connor, Daniel H -- Huber, Daniel -- Svoboda, Karel -- Howard Hughes Medical Institute/ -- England -- Nature. 2009 Oct 15;461(7266):923-9. doi: 10.1038/nature08539.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19829372" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Behavior, Animal/physiology ; Brain/*cytology/*metabolism/physiology ; Mice ; Neural Pathways/*physiology ; Somatosensory Cortex/cytology/metabolism/physiology
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  • 3
    Publication Date: 2011-04-09
    Description: Hierarchical triple systems comprise a close binary and a more distant component. They are important for testing theories of star formation and of stellar evolution in the presence of nearby companions. We obtained 218 days of Kepler photometry of HD 181068 (magnitude of 7.1), supplemented by ground-based spectroscopy and interferometry, which show it to be a hierarchical triple with two types of mutual eclipses. The primary is a red giant that is in a 45-day orbit with a pair of red dwarfs in a close 0.9-day orbit. The red giant shows evidence for tidally induced oscillations that are driven by the orbital motion of the close pair. HD 181068 is an ideal target for studies of dynamical evolution and testing tidal friction theories in hierarchical triple systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Derekas, A -- Kiss, L L -- Borkovits, T -- Huber, D -- Lehmann, H -- Southworth, J -- Bedding, T R -- Balam, D -- Hartmann, M -- Hrudkova, M -- Ireland, M J -- Kovacs, J -- Mezo, Gy -- Moor, A -- Niemczura, E -- Sarty, G E -- Szabo, Gy M -- Szabo, R -- Telting, J H -- Tkachenko, A -- Uytterhoeven, K -- Benko, J M -- Bryson, S T -- Maestro, V -- Simon, A E -- Stello, D -- Schaefer, G -- Aerts, C -- ten Brummelaar, T A -- De Cat, P -- McAlister, H A -- Maceroni, C -- Merand, A -- Still, M -- Sturmann, J -- Sturmann, L -- Turner, N -- Tuthill, P G -- Christensen-Dalsgaard, J -- Gilliland, R L -- Kjeldsen, H -- Quintana, E V -- Tenenbaum, P -- Twicken, J D -- New York, N.Y. -- Science. 2011 Apr 8;332(6026):216-8. doi: 10.1126/science.1201762.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, Eotvos University, Budapest, Hungary. derekas@konkoly.hu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21474755" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 4
    Publication Date: 2012-08-31
    Description: We report the detection of Kepler-47, a system consisting of two planets orbiting around an eclipsing pair of stars. The inner and outer planets have radii 3.0 and 4.6 times that of Earth, respectively. The binary star consists of a Sun-like star and a companion roughly one-third its size, orbiting each other every 7.45 days. With an orbital period of 49.5 days, 18 transits of the inner planet have been observed, allowing a detailed characterization of its orbit and those of the stars. The outer planet's orbital period is 303.2 days, and although the planet is not Earth-like, it resides within the classical "habitable zone," where liquid water could exist on an Earth-like planet. With its two known planets, Kepler-47 establishes that close binary stars can host complete planetary systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orosz, Jerome A -- Welsh, William F -- Carter, Joshua A -- Fabrycky, Daniel C -- Cochran, William D -- Endl, Michael -- Ford, Eric B -- Haghighipour, Nader -- MacQueen, Phillip J -- Mazeh, Tsevi -- Sanchis-Ojeda, Roberto -- Short, Donald R -- Torres, Guillermo -- Agol, Eric -- Buchhave, Lars A -- Doyle, Laurance R -- Isaacson, Howard -- Lissauer, Jack J -- Marcy, Geoffrey W -- Shporer, Avi -- Windmiller, Gur -- Barclay, Thomas -- Boss, Alan P -- Clarke, Bruce D -- Fortney, Jonathan -- Geary, John C -- Holman, Matthew J -- Huber, Daniel -- Jenkins, Jon M -- Kinemuchi, Karen -- Kruse, Ethan -- Ragozzine, Darin -- Sasselov, Dimitar -- Still, Martin -- Tenenbaum, Peter -- Uddin, Kamal -- Winn, Joshua N -- Koch, David G -- Borucki, William J -- New York, N.Y. -- Science. 2012 Sep 21;337(6101):1511-4. Epub 2012 Aug 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Astronomy Department, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA. orosz@sciences.sdsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22933522" target="_blank"〉PubMed〈/a〉
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  • 5
    Publication Date: 2013-10-19
    Description: Stars hosting hot Jupiters are often observed to have high obliquities, whereas stars with multiple coplanar planets have been seen to have low obliquities. This has been interpreted as evidence that hot-Jupiter formation is linked to dynamical disruption, as opposed to planet migration through a protoplanetary disk. We used asteroseismology to measure a large obliquity for Kepler-56, a red giant star hosting two transiting coplanar planets. These observations show that spin-orbit misalignments are not confined to hot-Jupiter systems. Misalignments in a broader class of systems had been predicted as a consequence of torques from wide-orbiting companions, and indeed radial velocity measurements revealed a third companion in a wide orbit in the Kepler-56 system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, Daniel -- Carter, Joshua A -- Barbieri, Mauro -- Miglio, Andrea -- Deck, Katherine M -- Fabrycky, Daniel C -- Montet, Benjamin T -- Buchhave, Lars A -- Chaplin, William J -- Hekker, Saskia -- Montalban, Josefina -- Sanchis-Ojeda, Roberto -- Basu, Sarbani -- Bedding, Timothy R -- Campante, Tiago L -- Christensen-Dalsgaard, Jorgen -- Elsworth, Yvonne P -- Stello, Dennis -- Arentoft, Torben -- Ford, Eric B -- Gilliland, Ronald L -- Handberg, Rasmus -- Howard, Andrew W -- Isaacson, Howard -- Johnson, John Asher -- Karoff, Christoffer -- Kawaler, Steven D -- Kjeldsen, Hans -- Latham, David W -- Lund, Mikkel N -- Lundkvist, Mia -- Marcy, Geoffrey W -- Metcalfe, Travis S -- Silva Aguirre, Victor -- Winn, Joshua N -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):331-4. doi: 10.1126/science.1242066.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Ames Research Center, MS 244-30, Moffett Field, CA 94035, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136961" target="_blank"〉PubMed〈/a〉
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  • 6
    Publication Date: 2013-04-20
    Description: We present the detection of five planets--Kepler-62b, c, d, e, and f--of size 1.31, 0.54, 1.95, 1.61 and 1.41 Earth radii (R plus sign in circle), orbiting a K2V star at periods of 5.7, 12.4, 18.2, 122.4, and 267.3 days, respectively. The outermost planets, Kepler-62e and -62f, are super-Earth-size (1.25 R plus sign in circle 〈 planet radius 〈/= 2.0 R plus sign in circle) planets in the habitable zone of their host star, respectively receiving 1.2 +/- 0.2 times and 0.41 +/- 0.05 times the solar flux at Earth's orbit. Theoretical models of Kepler-62e and -62f for a stellar age of ~7 billion years suggest that both planets could be solid, either with a rocky composition or composed of mostly solid water in their bulk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borucki, William J -- Agol, Eric -- Fressin, Francois -- Kaltenegger, Lisa -- Rowe, Jason -- Isaacson, Howard -- Fischer, Debra -- Batalha, Natalie -- Lissauer, Jack J -- Marcy, Geoffrey W -- Fabrycky, Daniel -- Desert, Jean-Michel -- Bryson, Stephen T -- Barclay, Thomas -- Bastien, Fabienne -- Boss, Alan -- Brugamyer, Erik -- Buchhave, Lars A -- Burke, Chris -- Caldwell, Douglas A -- Carter, Josh -- Charbonneau, David -- Crepp, Justin R -- Christensen-Dalsgaard, Jorgen -- Christiansen, Jessie L -- Ciardi, David -- Cochran, William D -- DeVore, Edna -- Doyle, Laurance -- Dupree, Andrea K -- Endl, Michael -- Everett, Mark E -- Ford, Eric B -- Fortney, Jonathan -- Gautier, Thomas N 3rd -- Geary, John C -- Gould, Alan -- Haas, Michael -- Henze, Christopher -- Howard, Andrew W -- Howell, Steve B -- Huber, Daniel -- Jenkins, Jon M -- Kjeldsen, Hans -- Kolbl, Rea -- Kolodziejczak, Jeffery -- Latham, David W -- Lee, Brian L -- Lopez, Eric -- Mullally, Fergal -- Orosz, Jerome A -- Prsa, Andrej -- Quintana, Elisa V -- Sanchis-Ojeda, Roberto -- Sasselov, Dimitar -- Seader, Shawn -- Shporer, Avi -- Steffen, Jason H -- Still, Martin -- Tenenbaum, Peter -- Thompson, Susan E -- Torres, Guillermo -- Twicken, Joseph D -- Welsh, William F -- Winn, Joshua N -- New York, N.Y. -- Science. 2013 May 3;340(6132):587-90. doi: 10.1126/science.1234702. Epub 2013 Apr 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Ames Research Center, Moffett Field, CA 94035, USA. william.j.borucki@nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599262" target="_blank"〉PubMed〈/a〉
    Keywords: Exobiology ; Extraterrestrial Environment ; Models, Theoretical ; *Planets ; Stars, Celestial ; *Water
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  • 7
    Publication Date: 2005-04-12
    Description: Vasopressin and oxytocin strongly modulate autonomic fear responses, through mechanisms that are still unclear. We describe how these neuropeptides excite distinct neuronal populations in the central amygdala, which provides the major output of the amygdaloid complex to the autonomic nervous system. We identified these two neuronal populations as part of an inhibitory network, through which vasopressin and oxytocin modulate the integration of excitatory information from the basolateral amygdala and cerebral cortex in opposite manners. Through this network, the expression and endogenous activation of vasopressin and oxytocin receptors may regulate the autonomic expression of fear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, Daniel -- Veinante, Pierre -- Stoop, Ron -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):245-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular Biology and Morphology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821089" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/cytology/drug effects/*physiology ; Animals ; Antidiuretic Hormone Receptor Antagonists ; Autoradiography ; Fear/physiology ; In Vitro Techniques ; Neurons/*physiology ; Oxytocin/*analogs & derivatives/pharmacology/*physiology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Receptors, Oxytocin/agonists/antagonists & inhibitors/metabolism ; Receptors, Vasopressin/agonists/metabolism ; Tetrodotoxin/pharmacology ; Vasopressins/*physiology ; gamma-Aminobutyric Acid/metabolism
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  • 8
    Publication Date: 2012-11-13
    Description: Active dendrites provide neurons with powerful processing capabilities. However, little is known about the role of neuronal dendrites in behaviourally related circuit computations. Here we report that a novel global dendritic nonlinearity is involved in the integration of sensory and motor information within layer 5 pyramidal neurons during an active sensing behaviour. Layer 5 pyramidal neurons possess elaborate dendritic arborizations that receive functionally distinct inputs, each targeted to spatially separate regions. At the cellular level, coincident input from these segregated pathways initiates regenerative dendritic electrical events that produce bursts of action potential output and circuits featuring this powerful dendritic nonlinearity can implement computations based on input correlation. To examine this in vivo we recorded dendritic activity in layer 5 pyramidal neurons in the barrel cortex using two-photon calcium imaging in mice performing an object-localization task. Large-amplitude, global calcium signals were observed throughout the apical tuft dendrites when active touch occurred at particular object locations or whisker angles. Such global calcium signals are produced by dendritic plateau potentials that require both vibrissal sensory input and primary motor cortex activity. These data provide direct evidence of nonlinear dendritic processing of correlated sensory and motor information in the mammalian neocortex during active sensation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Ning-long -- Harnett, Mark T -- Williams, Stephen R -- Huber, Daniel -- O'Connor, Daniel H -- Svoboda, Karel -- Magee, Jeffrey C -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Dec 13;492(7428):247-51. doi: 10.1038/nature11601. Epub 2012 Nov 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23143335" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Calcium/metabolism ; Dendrites/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity/*physiology ; Patch-Clamp Techniques ; Pyramidal Cells/physiology ; Sensation/*physiology ; Signal Transduction
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  • 9
    Publication Date: 2013-02-22
    Description: Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hitherto, no planets have been found that are smaller than those we see in the Solar System. Here we report a planet significantly smaller than Mercury. This tiny planet is the innermost of three that orbit the Sun-like host star, which we have designated Kepler-37. Owing to its extremely small size, similar to that of the Moon, and highly irradiated surface, the planet, Kepler-37b, is probably rocky with no atmosphere or water, similar to Mercury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barclay, Thomas -- Rowe, Jason F -- Lissauer, Jack J -- Huber, Daniel -- Fressin, Francois -- Howell, Steve B -- Bryson, Stephen T -- Chaplin, William J -- Desert, Jean-Michel -- Lopez, Eric D -- Marcy, Geoffrey W -- Mullally, Fergal -- Ragozzine, Darin -- Torres, Guillermo -- Adams, Elisabeth R -- Agol, Eric -- Barrado, David -- Basu, Sarbani -- Bedding, Timothy R -- Buchhave, Lars A -- Charbonneau, David -- Christiansen, Jessie L -- Christensen-Dalsgaard, Jorgen -- Ciardi, David -- Cochran, William D -- Dupree, Andrea K -- Elsworth, Yvonne -- Everett, Mark -- Fischer, Debra A -- Ford, Eric B -- Fortney, Jonathan J -- Geary, John C -- Haas, Michael R -- Handberg, Rasmus -- Hekker, Saskia -- Henze, Christopher E -- Horch, Elliott -- Howard, Andrew W -- Hunter, Roger C -- Isaacson, Howard -- Jenkins, Jon M -- Karoff, Christoffer -- Kawaler, Steven D -- Kjeldsen, Hans -- Klaus, Todd C -- Latham, David W -- Li, Jie -- Lillo-Box, Jorge -- Lund, Mikkel N -- Lundkvist, Mia -- Metcalfe, Travis S -- Miglio, Andrea -- Morris, Robert L -- Quintana, Elisa V -- Stello, Dennis -- Smith, Jeffrey C -- Still, Martin -- Thompson, Susan E -- England -- Nature. 2013 Feb 28;494(7438):452-4. doi: 10.1038/nature11914. Epub 2013 Feb 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Ames Research Center, Moffett Field, California 94035, USA. thomas.barclay@nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23426260" target="_blank"〉PubMed〈/a〉
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  • 10
    Publication Date: 2011-04-02
    Description: Red giants are evolved stars that have exhausted the supply of hydrogen in their cores and instead burn hydrogen in a surrounding shell. Once a red giant is sufficiently evolved, the helium in the core also undergoes fusion. Outstanding issues in our understanding of red giants include uncertainties in the amount of mass lost at the surface before helium ignition and the amount of internal mixing from rotation and other processes. Progress is hampered by our inability to distinguish between red giants burning helium in the core and those still only burning hydrogen in a shell. Asteroseismology offers a way forward, being a powerful tool for probing the internal structures of stars using their natural oscillation frequencies. Here we report observations of gravity-mode period spacings in red giants that permit a distinction between evolutionary stages to be made. We use high-precision photometry obtained by the Kepler spacecraft over more than a year to measure oscillations in several hundred red giants. We find many stars whose dipole modes show sequences with approximately regular period spacings. These stars fall into two clear groups, allowing us to distinguish unambiguously between hydrogen-shell-burning stars (period spacing mostly approximately 50 seconds) and those that are also burning helium (period spacing approximately 100 to 300 seconds).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bedding, Timothy R -- Mosser, Benoit -- Huber, Daniel -- Montalban, Josefina -- Beck, Paul -- Christensen-Dalsgaard, Jorgen -- Elsworth, Yvonne P -- Garcia, Rafael A -- Miglio, Andrea -- Stello, Dennis -- White, Timothy R -- De Ridder, Joris -- Hekker, Saskia -- Aerts, Conny -- Barban, Caroline -- Belkacem, Kevin -- Broomhall, Anne-Marie -- Brown, Timothy M -- Buzasi, Derek L -- Carrier, Fabien -- Chaplin, William J -- Di Mauro, Maria Pia -- Dupret, Marc-Antoine -- Frandsen, Soren -- Gilliland, Ronald L -- Goupil, Marie-Jo -- Jenkins, Jon M -- Kallinger, Thomas -- Kawaler, Steven -- Kjeldsen, Hans -- Mathur, Savita -- Noels, Arlette -- Aguirre, Victor Silva -- Ventura, Paolo -- England -- Nature. 2011 Mar 31;471(7340):608-11. doi: 10.1038/nature09935.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sydney Institute for Astronomy, School of Physics, University of Sydney, New South Wales 2006, Australia. t.bedding@physics.usyd.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21455175" target="_blank"〉PubMed〈/a〉
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