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  • 1
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    Multiple-time-scale framework for understanding the progression of Parkinson's disease (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-12-16
    Description: Author(s): D. S. Andres, F. Gomez, F. A. S. Ferrari, D. Cerquetti, M. Merello, R. Viana, and R. Stoop Parkinson's disease is marked by neurodegenerative processes that affect the pattern of discharge of basal ganglia neurons. The main features observed in the parkinsonian globus pallidus pars interna (GPi), a subdomain of the basal ganglia that is involved in the regulation of voluntary movement, ar... [Phys. Rev. E 90, 062709] Published Mon Dec 15, 2014
    Keywords: Biological Physics
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Oxytocin selectively gates fear responses through distinct outputs from the central amygdala (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-02
    Description: Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Viviani, Daniele -- Charlet, Alexandre -- van den Burg, Erwin -- Robinet, Camille -- Hurni, Nicolas -- Abatis, Marios -- Magara, Fulvio -- Stoop, Ron -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):104-7. doi: 10.1126/science.1201043.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital Center, University of Lausanne, CH-1015 Lausanne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719680" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/*physiology ; Animals ; Bombesin/pharmacology ; Brain Stem/*physiology ; Conditioning (Psychology) ; Fear/*physiology ; Female ; GABA-A Receptor Agonists/pharmacology ; Heart Rate/drug effects ; Hypothalamus/*physiology ; Male ; Muscimol/pharmacology ; Neural Inhibition ; Neural Pathways/physiology ; Neurons/*physiology ; Oxytocin/agonists/analogs & derivatives/pharmacology/*physiology ; Patch-Clamp Techniques ; Periaqueductal Gray/*physiology ; Rats ; Rats, Sprague-Dawley
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-12
    Description: Vasopressin and oxytocin strongly modulate autonomic fear responses, through mechanisms that are still unclear. We describe how these neuropeptides excite distinct neuronal populations in the central amygdala, which provides the major output of the amygdaloid complex to the autonomic nervous system. We identified these two neuronal populations as part of an inhibitory network, through which vasopressin and oxytocin modulate the integration of excitatory information from the basolateral amygdala and cerebral cortex in opposite manners. Through this network, the expression and endogenous activation of vasopressin and oxytocin receptors may regulate the autonomic expression of fear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, Daniel -- Veinante, Pierre -- Stoop, Ron -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):245-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular Biology and Morphology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821089" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/cytology/drug effects/*physiology ; Animals ; Antidiuretic Hormone Receptor Antagonists ; Autoradiography ; Fear/physiology ; In Vitro Techniques ; Neurons/*physiology ; Oxytocin/*analogs & derivatives/pharmacology/*physiology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Receptors, Oxytocin/agonists/antagonists & inhibitors/metabolism ; Receptors, Vasopressin/agonists/metabolism ; Tetrodotoxin/pharmacology ; Vasopressins/*physiology ; gamma-Aminobutyric Acid/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-02-03
    Description: Neurotrophic factors participate in the development and maintenance of the nervous system. Application of ciliary neurotrophic factor (CNTF), a protein that promotes survival of motor neurons, resulted in an immediate potentiation of spontaneous and impulse-evoked transmitter release at developing neuromuscular synapses in Xenopus cell cultures. When CNTF was applied at the synapse, the onset of the potentiation was slower than that produced by application at the cell body of the presynaptic neuron. The potentiation effect was abolished when the neurite shaft was severed from the cell body. Thus, transmitter secretion from the nerve terminals is under immediate somatic control and can be regulated by CNTF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stoop, R -- Poo, M M -- New York, N.Y. -- Science. 1995 Feb 3;267(5198):695-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Columbia University, New York, NY 10027.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7839148" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*metabolism ; Action Potentials/drug effects ; Animals ; Brain-Derived Neurotrophic Factor ; Calcium/metabolism ; Cells, Cultured ; Ciliary Neurotrophic Factor ; Cycloheximide/pharmacology ; Dactinomycin/pharmacology ; Nerve Tissue Proteins/metabolism/*pharmacology ; Neurites/physiology ; Neuromuscular Junction/drug effects/*metabolism ; Patch-Clamp Techniques ; Receptor, Ciliary Neurotrophic Factor ; Receptors, Nerve Growth Factor/metabolism ; *Signal Transduction ; Synapses/drug effects/*metabolism ; Synaptic Transmission ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Universal dynamical properties preclude standard clustering in a large class of biochemical data (2014)
    Oxford University Press
    Details
    Publication Date: 2014-08-27
    Description: Motivation: Clustering of chemical and biochemical data based on observed features is a central cognitive step in the analysis of chemical substances, in particular in combinatorial chemistry, or of complex biochemical reaction networks. Often, for reasons unknown to the researcher, this step produces disappointing results. Once the sources of the problem are known, improved clustering methods might revitalize the statistical approach of compound and reaction search and analysis. Here, we present a generic mechanism that may be at the origin of many clustering difficulties. Results: The variety of dynamical behaviors that can be exhibited by complex biochemical reactions on variation of the system parameters are fundamental system fingerprints. In parameter space, shrimp-like or swallow-tail structures separate parameter sets that lead to stable periodic dynamical behavior from those leading to irregular behavior. We work out the genericity of this phenomenon and demonstrate novel examples for their occurrence in realistic models of biophysics. Although we elucidate the phenomenon by considering the emergence of periodicity in dependence on system parameters in a low-dimensional parameter space, the conclusions from our simple setting are shown to continue to be valid for features in a higher-dimensional feature space, as long as the feature-generating mechanism is not too extreme and the dimension of this space is not too high compared with the amount of available data. Availability and implementation: For online versions of super-paramagnetic clustering see http://stoop.ini.uzh.ch/research/clustering . Contact: ruedi@ini.phys.ethz.ch Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 6
    Electronic Resource
    Electronic Resource
    Anomalous diffusion in iterated maps as escape from a strange repeller
    Amsterdam : Elsevier
    Chaos, Solitons and Fractals 4 (1994), S. 2043-2056 
    Details
    ISSN: 0960-0779
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0960-0779(94)90119-8
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    On the convergence of the thermodynamic averages in dissipative dynamical systems
    Amsterdam : Elsevier
    Physics Letters A 161 (1991), S. 67-70 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(91)90546-K
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  • 8
    Electronic Resource
    Electronic Resource
    On partial free energies and entropies
    Amsterdam : Elsevier
    Physics Letters A 167 (1992), S. 215-219 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(92)90231-A
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  • 9
    Electronic Resource
    Electronic Resource
    Lyapunov exponents and dimensions determined from experimental time series
    Amsterdam : Elsevier
    Nuclear Physics B (Proceedings Supplements) 2 (1987), S. 582 
    Details
    ISSN: 0920-5632
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0920-5632(87)90058-2
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  • 10
    Electronic Resource
    Electronic Resource
    On hyberbolic elements hiding phase transitions
    Amsterdam : Elsevier
    Physics Letters A 173 (1993), S. 369-372 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(93)90252-U
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