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  • Articles  (1,389)
  • American Association for the Advancement of Science (AAAS)  (595)
  • Springer  (460)
  • International Union of Crystallography  (327)
  • Annual Reviews  (5)
  • Oxford University Press
  • 2000-2004  (1,389)
  • 1980-1984
  • 1975-1979
  • 1970-1974
  • 2004  (1,389)
  • Chemistry and Pharmacology  (1,389)
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  • Articles  (1,389)
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  • 2000-2004  (1,389)
  • 1980-1984
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  • 11
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    Toward Heisenberg-limited spectroscopy with multiparticle entangled states (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-05
    Description: The precision in spectroscopy of any quantum system is fundamentally limited by the Heisenberg uncertainty relation for energy and time. For N systems, this limit requires that they be in a quantum-mechanically entangled state. We describe a scalable method of spectroscopy that can potentially take full advantage of entanglement to reach the Heisenberg limit and has the practical advantage that the spectroscopic information is transferred to states with optimal protection against readout noise. We demonstrate our method experimentally with three beryllium ions. The spectroscopic sensitivity attained is 1.45(2) times as high as that of a perfect experiment with three non-entangled particles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leibfried, D -- Barrett, M D -- Schaetz, T -- Britton, J -- Chiaverini, J -- Itano, W M -- Jost, J D -- Langer, C -- Wineland, D J -- New York, N.Y. -- Science. 2004 Jun 4;304(5676):1476-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Standards and Technology, 325 Broadway, Boulder, CO 80305, USA. dil@boulder.nist.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15178794" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Regions of strong coupling between soil moisture and precipitation (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-25
    Description: Previous estimates of land-atmosphere interaction (the impact of soil moisture on precipitation) have been limited by a lack of observational data and by the model dependence of computational estimates. To counter the second limitation, a dozen climate-modeling groups have recently performed the same highly controlled numerical experiment as part of a coordinated comparison project. This allows a multimodel estimation of the regions on Earth where precipitation is affected by soil moisture anomalies during Northern Hemisphere summer. Potential benefits of this estimation may include improved seasonal rainfall forecasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koster, Randal D -- Dirmeyer, Paul A -- Guo, Zhichang -- Bonan, Gordon -- Chan, Edmond -- Cox, Peter -- Gordon, C T -- Kanae, Shinjiro -- Kowalczyk, Eva -- Lawrence, David -- Liu, Ping -- Lu, Cheng-Hsuan -- Malyshev, Sergey -- McAvaney, Bryant -- Mitchell, Ken -- Mocko, David -- Oki, Taikan -- Oleson, Keith -- Pitman, Andrew -- Sud, Y C -- Taylor, Christopher M -- Verseghy, Diana -- Vasic, Ratko -- Xue, Yongkang -- Yamada, Tomohito -- GLACE Team -- New York, N.Y. -- Science. 2004 Aug 20;305(5687):1138-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA. randal.d.koster@nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15326351" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Setting priorities for genomic research (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berrettini, Wade -- Bierut, Laura -- Crowley, Thomas J -- Cubells, Joseph F -- Frascella, Joseph -- Gelernter, Joel -- Hewitt, John K -- Kreek, Mary Jeanne -- Lachman, Herb -- Leppert, Mark -- Li, Ming D -- Madden, Pamela -- Miner, Cindy -- Pollock, Jonathan D -- Pomerleau, Ovide -- Rice, John P -- Rutter, Joni L -- Shurtleff, David -- Swan, Gary E -- Tischfield, Jay A -- Tsuang, Ming -- Uhl, George R -- Vanyukov, Michael -- Volkow, Nora D -- Wanke, Kay -- New York, N.Y. -- Science. 2004 Jun 4;304(5676):1445-7; author reply 1445-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15178784" target="_blank"〉PubMed〈/a〉
    Keywords: Environment ; Genetic Predisposition to Disease ; *Genetic Research ; Genetics, Medical ; *Genomics ; Humans ; Life Style ; *Public Health ; Risk Factors ; Substance-Related Disorders/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    A map of the interactome network of the metazoan C. elegans (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-06
    Description: To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains approximately 5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698949/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698949/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Siming -- Armstrong, Christopher M -- Bertin, Nicolas -- Ge, Hui -- Milstein, Stuart -- Boxem, Mike -- Vidalain, Pierre-Olivier -- Han, Jing-Dong J -- Chesneau, Alban -- Hao, Tong -- Goldberg, Debra S -- Li, Ning -- Martinez, Monica -- Rual, Jean-Francois -- Lamesch, Philippe -- Xu, Lai -- Tewari, Muneesh -- Wong, Sharyl L -- Zhang, Lan V -- Berriz, Gabriel F -- Jacotot, Laurent -- Vaglio, Philippe -- Reboul, Jerome -- Hirozane-Kishikawa, Tomoko -- Li, Qianru -- Gabel, Harrison W -- Elewa, Ahmed -- Baumgartner, Bridget -- Rose, Debra J -- Yu, Haiyuan -- Bosak, Stephanie -- Sequerra, Reynaldo -- Fraser, Andrew -- Mango, Susan E -- Saxton, William M -- Strome, Susan -- Van Den Heuvel, Sander -- Piano, Fabio -- Vandenhaute, Jean -- Sardet, Claude -- Gerstein, Mark -- Doucette-Stamm, Lynn -- Gunsalus, Kristin C -- Harper, J Wade -- Cusick, Michael E -- Roth, Frederick P -- Hill, David E -- Vidal, Marc -- R01 AG011085/AG/NIA NIH HHS/ -- R01 GM034059/GM/NIGMS NIH HHS/ -- R01 GM034059-18/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):540-3. Epub 2004 Jan 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14704431" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/genetics/*metabolism ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Computational Biology ; Evolution, Molecular ; Genes, Helminth ; Genomics ; Open Reading Frames ; Phenotype ; Protein Binding ; Proteome/*metabolism ; Transcription, Genetic ; Two-Hybrid System Techniques
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 15
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    Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-13
    Description: We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazuda, Daria J -- Young, Steven D -- Guare, James P -- Anthony, Neville J -- Gomez, Robert P -- Wai, John S -- Vacca, Joseph P -- Handt, Larry -- Motzel, Sherri L -- Klein, Hilton J -- Dornadula, Geethanjali -- Danovich, Robert M -- Witmer, Marc V -- Wilson, Keith A A -- Tussey, Lynda -- Schleif, William A -- Gabryelski, Lori S -- Jin, Lixia -- Miller, Michael D -- Casimiro, Danilo R -- Emini, Emilio A -- Shiver, John W -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):528-32. Epub 2004 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, Merck Research Laboratories, Post Office Box 4, West Point, PA 19486, USA. daria_hazuda@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247437" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy/*immunology/virology ; Animals ; Anti-HIV Agents/administration & dosage/blood/pharmacology/therapeutic use ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Drug Resistance, Viral ; HIV Integrase/genetics/metabolism ; HIV Integrase Inhibitors/administration & dosage/blood/pharmacology/therapeutic ; use ; HIV-1/drug effects/enzymology/genetics/*physiology ; Immunity, Cellular ; Integrase Inhibitors/administration & dosage/blood/pharmacology/*therapeutic use ; Integrases/genetics/metabolism ; Leukocytes, Mononuclear/virology ; Macaca mulatta ; Mutation ; Naphthyridines/administration & dosage/blood/pharmacology/*therapeutic use ; Simian Acquired Immunodeficiency Syndrome/*drug therapy/*immunology/virology ; Simian Immunodeficiency Virus/drug effects/enzymology/genetics/*physiology ; Viral Load ; Viremia/drug therapy ; Virus Replication/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Mineralogy at Meridiani Planum from the Mini-TES Experiment on the Opportunity Rover (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-04
    Description: The Miniature Thermal Emission Spectrometer (Mini-TES) on Opportunity investigated the mineral abundances and compositions of outcrops, rocks, and soils at Meridiani Planum. Coarse crystalline hematite and olivine-rich basaltic sands were observed as predicted from orbital TES spectroscopy. Outcrops of aqueous origin are composed of 15 to 35% by volume magnesium and calcium sulfates [a high-silica component modeled as a combination of glass, feldspar, and sheet silicates (approximately 20 to 30%)], and hematite; only minor jarosite is identified in Mini-TES spectra. Mini-TES spectra show only a hematite signature in the millimeter-sized spherules. Basaltic materials have more plagioclase than pyroxene, contain olivine, and are similar in inferred mineral composition to basalt mapped from orbit. Bounce rock is dominated by clinopyroxene and is close in inferred mineral composition to the basaltic martian meteorites. Bright wind streak material matches global dust. Waterlain rocks covered by unaltered basaltic sands suggest a change from an aqueous environment to one dominated by physical weathering.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Christensen, P R -- Wyatt, M B -- Glotch, T D -- Rogers, A D -- Anwar, S -- Arvidson, R E -- Bandfield, J L -- Blaney, D L -- Budney, C -- Calvin, W M -- Fallacaro, A -- Fergason, R L -- Gorelick, N -- Graff, T G -- Hamilton, V E -- Hayes, A G -- Johnson, J R -- Knudson, A T -- McSween, H Y Jr -- Mehall, G L -- Mehall, L K -- Moersch, J E -- Morris, R V -- Smith, M D -- Squyres, S W -- Ruff, S W -- Wolff, M J -- New York, N.Y. -- Science. 2004 Dec 3;306(5702):1733-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geological Sciences, Arizona State University, Tempe, AZ 85287, USA. phil.christensen@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15576609" target="_blank"〉PubMed〈/a〉
    Keywords: Calcium Sulfate ; Extraterrestrial Environment ; Ferric Compounds ; Geologic Sediments ; Iron Compounds ; Magnesium Compounds ; Magnesium Sulfate ; *Mars ; *Minerals ; Silicates ; Spacecraft ; Sulfates ; Water
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  • 17
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    Temperatures, winds, and composition in the saturnian system (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: Stratospheric temperatures on Saturn imply a strong decay of the equatorial winds with altitude. If the decrease in winds reported from recent Hubble Space Telescope images is not a temporal change, then the features tracked must have been at least 130 kilometers higher than in earlier studies. Saturn's south polar stratosphere is warmer than predicted from simple radiative models. The C/H ratio on Saturn is seven times solar, twice Jupiter's. Saturn's ring temperatures have radial variations down to the smallest scale resolved (100 kilometers). Diurnal surface temperature variations on Phoebe suggest a more porous regolith than on the jovian satellites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flasar, F M -- Achterberg, R K -- Conrath, B J -- Pearl, J C -- Bjoraker, G L -- Jennings, D E -- Romani, P N -- Simon-Miller, A A -- Kunde, V G -- Nixon, C A -- Bezard, B -- Orton, G S -- Spilker, L J -- Spencer, J R -- Irwin, P G J -- Teanby, N A -- Owen, T C -- Brasunas, J -- Segura, M E -- Carlson, R C -- Mamoutkine, A -- Gierasch, P J -- Schinder, P J -- Showalter, M R -- Ferrari, C -- Barucci, A -- Courtin, R -- Coustenis, A -- Fouchet, T -- Gautier, D -- Lellouch, E -- Marten, A -- Prange, R -- Strobel, D F -- Calcutt, S B -- Read, P L -- Taylor, F W -- Bowles, N -- Samuelson, R E -- Abbas, M M -- Raulin, F -- Ade, P -- Edgington, S -- Pilorz, S -- Wallis, B -- Wishnow, E H -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1247-51. Epub 2004 Dec 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Aeronautics and Space Administration (NASA)/Goddard Space Flight Center, Code 693, Greenbelt, MD 20771, USA. f.m.flasar@nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618486" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Carbon ; Extraterrestrial Environment ; Hydrogen ; Methane ; *Saturn ; Spacecraft ; Spectrum Analysis ; Temperature ; Wind
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Environmental genome shotgun sequencing of the Sargasso Sea (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-07
    Description: We have applied "whole-genome shotgun sequencing" to microbial populations collected en masse on tangential flow and impact filters from seawater samples collected from the Sargasso Sea near Bermuda. A total of 1.045 billion base pairs of nonredundant sequence was generated, annotated, and analyzed to elucidate the gene content, diversity, and relative abundance of the organisms within these environmental samples. These data are estimated to derive from at least 1800 genomic species based on sequence relatedness, including 148 previously unknown bacterial phylotypes. We have identified over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors. Variation in species present and stoichiometry suggests substantial oceanic microbial diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Venter, J Craig -- Remington, Karin -- Heidelberg, John F -- Halpern, Aaron L -- Rusch, Doug -- Eisen, Jonathan A -- Wu, Dongying -- Paulsen, Ian -- Nelson, Karen E -- Nelson, William -- Fouts, Derrick E -- Levy, Samuel -- Knap, Anthony H -- Lomas, Michael W -- Nealson, Ken -- White, Owen -- Peterson, Jeremy -- Hoffman, Jeff -- Parsons, Rachel -- Baden-Tillson, Holly -- Pfannkoch, Cynthia -- Rogers, Yu-Hui -- Smith, Hamilton O -- New York, N.Y. -- Science. 2004 Apr 2;304(5667):66-74. Epub 2004 Mar 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biological Energy Alternatives, 1901 Research Boulevard, Rockville, MD 20850, USA. jcventer@tcag.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001713" target="_blank"〉PubMed〈/a〉
    Keywords: Archaea/*genetics ; Atlantic Ocean ; Bacteria/*genetics ; Bacteriophages/genetics ; Biodiversity ; Computational Biology ; Cyanobacteria/genetics/growth & development/metabolism ; *Ecosystem ; Eukaryotic Cells ; Genes, Archaeal ; Genes, Bacterial ; Genes, rRNA ; Genome, Archaeal ; *Genome, Bacterial ; *Genomics ; Molecular Sequence Data ; Photosynthesis ; Phylogeny ; Plasmids ; Rhodopsin/genetics ; Rhodopsins, Microbial ; Seawater/*microbiology ; *Sequence Analysis, DNA ; Water Microbiology
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  • 19
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    The structure and receptor binding properties of the 1918 influenza hemagglutinin (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-07
    Description: The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gamblin, S J -- Haire, L F -- Russell, R J -- Stevens, D J -- Xiao, B -- Ha, Y -- Vasisht, N -- Steinhauer, D A -- Daniels, R S -- Elliot, A -- Wiley, D C -- Skehel, J J -- AI-13654/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council (MRC) National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14764886" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Birds ; Crystallography, X-Ray ; Hemagglutinin Glycoproteins, Influenza Virus/*chemistry/*metabolism ; History, 20th Century ; Humans ; Hydrogen Bonding ; Influenza A virus/*immunology/metabolism/pathogenicity ; Influenza, Human/epidemiology/history/*virology ; Membrane Glycoproteins/chemistry/metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Structure, Tertiary ; Receptors, Virus/*metabolism ; Sequence Alignment ; Sialic Acids/metabolism ; Species Specificity ; Swine
    Print ISSN: 0036-8075
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  • 20
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    Laser guide star adaptive optics imaging polarimetry of Herbig Ae/Be stars (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-28
    Description: We have used laser guide star adaptive optics and a near-infrared dual-channel imaging polarimeter to observe light scattered in the circumstellar environment of Herbig Ae/Be stars on scales of 100 to 300 astronomical units. We revealed a strongly polarized, biconical nebula 10 arc seconds (6000 astronomical units) in diameter around the star LkHalpha 198 and also observed a polarized jet-like feature associated with the deeply embedded source LkHalpha 198-IR. The star LkHalpha 233 presents a narrow, unpolarized dark lane consistent with an optically thick circumstellar disk blocking our direct view of the star. These data show that the lower-mass T Tauri and intermediate mass Herbig Ae/Be stars share a common evolutionary sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perrin, Marshall D -- Graham, James R -- Kalas, Paul -- Lloyd, James P -- Max, Claire E -- Gavel, Donald T -- Pennington, Deanna M -- Gates, Elinor L -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1345-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Astronomy Department, University of California Berkeley, Berkeley, CA 94720, USA. mperrin@astro.berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988558" target="_blank"〉PubMed〈/a〉
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