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  • *Ecosystem  (34)
  • Time Factors  (22)
  • American Association for the Advancement of Science (AAAS)  (55)
  • Springer Nature
  • 2000-2004  (45)
  • 1995-1999
  • 1980-1984  (10)
  • 1940-1944
  • 2002  (45)
  • 1981  (10)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (55)
  • Springer Nature
Years
  • 2000-2004  (45)
  • 1995-1999
  • 1980-1984  (10)
  • 1940-1944
Year
  • 1
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    Ascent of dinosaurs linked to an iridium anomaly at the Triassic-Jurassic boundary (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-23
    Description: Analysis of tetrapod footprints and skeletal material from more than 70 localities in eastern North America shows that large theropod dinosaurs appeared less than 10,000 years after the Triassic-Jurassic boundary and less than 30,000 years after the last Triassic taxa, synchronous with a terrestrial mass extinction. This extraordinary turnover is associated with an iridium anomaly (up to 285 parts per trillion, with an average maximum of 141 parts per trillion) and a fern spore spike, suggesting that a bolide impact was the cause. Eastern North American dinosaurian diversity reached a stable maximum less than 100,000 years after the boundary, marking the establishment of dinosaur-dominated communities that prevailed for the next 135 million years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olsen, P E -- Kent, D V -- Sues, H-D -- Koeberl, C -- Huber, H -- Montanari, A -- Rainforth, E C -- Fowell, S J -- Szajna, M J -- Hartline, B W -- New York, N.Y. -- Science. 2002 May 17;296(5571):1305-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lamont-Doherty Earth Observatory of Columbia University, Palisades, NY 10964, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016313" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; *Dinosaurs ; *Ecosystem ; Ferns ; *Fossils ; Geologic Sediments/chemistry ; Iridium/*analysis ; Meteoroids ; Minor Planets ; North America ; Spores ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-01-19
    Description: To explore neuronal mechanisms underlying long-term consequences of stress, we studied stress-induced changes in the neuritic translocation of acetylcholinesterase (AChE) splice variants. Under normal conditions, we found the synaptic AChE-S mRNA and protein in neurites. Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion. Weeks after stress, electrophysiological measurements in hippocampus slices displayed apparently normal evoked synaptic responses but extreme hypersensitivity to both anticholinesterases and atropine. Our findings suggest that neuronal hypersensitivity under stress involves neuritic replacement of AChE-S with AChE-R.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meshorer, Eran -- Erb, Christina -- Gazit, Roi -- Pavlovsky, Lev -- Kaufer, Daniela -- Friedman, Alon -- Glick, David -- Ben-Arie, Nissim -- Soreq, Hermona -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):508-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799248" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Acetylcholinesterase/*genetics/*metabolism ; Action Potentials ; *Alternative Splicing ; Animals ; Atropine/pharmacology ; Cells, Cultured ; Cerebellum/cytology ; Cholinesterase Inhibitors/pharmacology ; Corticosterone/pharmacology ; Hippocampus/cytology/metabolism/physiology ; In Situ Hybridization, Fluorescence ; In Vitro Techniques ; Mice ; Mice, Transgenic ; Neurites/*metabolism ; Neurons/*metabolism ; Oligonucleotides, Antisense/pharmacology ; PC12 Cells ; Physostigmine/pharmacology ; RNA, Messenger/genetics/*metabolism ; Rats ; Stress, Physiological/genetics/*physiopathology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-12
    Description: We have identified the xenobiotic receptor CAR (constitutive androstane receptor) as a key regulator of acetaminophen metabolism and hepatotoxicity. Known CAR activators as well as high doses of acetaminophen induced expression of three acetaminophen-metabolizing enzymes in wild-type but not in CAR null mice, and the CAR null mice were resistant to acetaminophen toxicity. Inhibition of CAR activity by administration of the inverse agonist ligand androstanol 1 hour after acetaminophen treatment blocked hepatotoxicity in wild type but not in CAR null mice. These results suggest an innovative therapeutic approach for treating the adverse effects of acetaminophen and potentially other hepatotoxic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Jun -- Huang, Wendong -- Chua, Steven S -- Wei, Ping -- Moore, David D -- R01 DK46546/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 11;298(5592):422-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12376703" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaminophen/metabolism/*toxicity ; Acetylcysteine/pharmacology ; Alanine Transaminase/blood ; Analgesics, Non-Narcotic/metabolism/toxicity ; Androstanols/pharmacology ; Animals ; Aryl Hydrocarbon Hydroxylases/genetics/metabolism ; Benzoquinones/metabolism ; Cytochrome P-450 CYP1A2/genetics/metabolism ; Cytochrome P-450 CYP2E1/genetics/metabolism ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/genetics/metabolism ; Glutathione/metabolism ; Glutathione S-Transferase pi ; Glutathione Transferase/genetics/metabolism ; Humans ; Imines/metabolism ; Isoenzymes/genetics/metabolism ; Liver/*drug effects/*metabolism/pathology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Oxidoreductases, N-Demethylating/genetics/metabolism ; Phenobarbital/pharmacology ; Pyridines/pharmacology ; RNA, Messenger/genetics/metabolism ; Receptors, Cytoplasmic and Nuclear/agonists/antagonists & ; inhibitors/genetics/*metabolism ; Time Factors ; Transcription Factors/agonists/antagonists & inhibitors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Antarctic krill under sea ice: elevated abundance in a narrow band just south of ice edge (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-09
    Description: We surveyed Antarctic krill (Euphausia superba) under sea ice using the autonomous underwater vehicle Autosub-2. Krill were concentrated within a band under ice between 1 and 13 kilometers south of the ice edge. Within this band, krill densities were fivefold greater than that of open water. The under-ice environment has long been considered an important habitat for krill, but sampling difficulties have previously prevented direct observations under ice over the scale necessary for robust krill density estimation. Autosub-2 enabled us to make continuous high-resolution measurements of krill density under ice reaching 27 kilometers beyond the ice edge.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brierley, Andrew S -- Fernandes, Paul G -- Brandon, Mark A -- Armstrong, Frederick -- Millard, Nicholas W -- McPhail, Steven D -- Stevenson, Peter -- Pebody, Miles -- Perrett, James -- Squires, Mark -- Bone, Douglas G -- Griffiths, Gwyn -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1890-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉British Antarctic Survey, High Cross, Madingley Road, Cambridge CB3 0ET, UK. andrew.brierley@st-andrews.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884754" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; Crustacea/*physiology ; *Ecosystem ; *Environment ; *Ice ; Oceans and Seas ; Population Density ; Regression Analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-23
    Description: The deposition of amyloid-beta (Abeta) peptides into amyloid plaques precedes the cognitive dysfunction of Alzheimer's disease (AD) by years. Biomarkers indicative of brain amyloid burden could be useful for identifying individuals at high risk for developing AD. As in AD in humans, baseline plasma Abeta levels in a transgenic mouse model of AD did not correlate with brain amyloid burden. However, after peripheral administration of a monoclonal antibody to Abeta (m266), we observed a rapid increase in plasma Abeta and the magnitude of this increase was highly correlated with amyloid burden in the hippocampus and cortex. This method may be useful for quantifying brain amyloid burden in patients at risk for or those who have been diagnosed with AD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeMattos, Ronald B -- Bales, Kelly R -- Cummins, David J -- Paul, Steven M -- Holtzman, David M -- AG20222/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 22;295(5563):2264-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Study of Nervous System Injury, Alzheimer's Disease Research Center, Department of Neurology, Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11910111" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*blood/genetics/*metabolism/pathology ; Amino Acid Substitution ; Amyloid beta-Peptides/*blood/chemistry/genetics/*metabolism ; Amyloidosis/blood/genetics/metabolism/pathology ; Animals ; Antibodies, Monoclonal/immunology ; Brain/*metabolism/pathology ; Cerebral Cortex/metabolism/pathology ; *Disease Models, Animal ; Hippocampus/metabolism/pathology ; Humans ; Mice ; Protein Transport ; Solubility ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Climate warming and disease risks for terrestrial and marine biota (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-22
    Description: Infectious diseases can cause rapid population declines or species extinctions. Many pathogens of terrestrial and marine taxa are sensitive to temperature, rainfall, and humidity, creating synergisms that could affect biodiversity. Climate warming can increase pathogen development and survival rates, disease transmission, and host susceptibility. Although most host-parasite systems are predicted to experience more frequent or severe disease impacts with warming, a subset of pathogens might decline with warming, releasing hosts from disease. Recently, changes in El Nino-Southern Oscillation events have had a detectable influence on marine and terrestrial pathogens, including coral diseases, oyster pathogens, crop pathogens, Rift Valley fever, and human cholera. To improve our ability to predict epidemics in wild populations, it will be necessary to separate the independent and interactive effects of multiple climate drivers on disease impact.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvell, C Drew -- Mitchell, Charles E -- Ward, Jessica R -- Altizer, Sonia -- Dobson, Andrew P -- Ostfeld, Richard S -- Samuel, Michael D -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2158-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA. cdh5@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic ; *Animals, Wild ; Bacterial Physiological Phenomena ; *Climate ; Communicable Diseases, Emerging/epidemiology/etiology/transmission/veterinary ; Disease Outbreaks ; Disease Vectors ; *Ecosystem ; Fungi/physiology ; Humans ; *Infection/epidemiology/etiology/transmission/veterinary ; Parasites/physiology ; *Plant Diseases/etiology ; Risk Factors ; Seasons ; Seawater ; Temperature ; Virus Physiological Phenomena
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Rates of evolution in ancient DNA from Adelie penguins (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-23
    Description: Well-preserved subfossil bones of Adelie penguins, Pygoscelis adeliae, underlie existing and abandoned nesting colonies in Antarctica. These bones, dating back to more than 7000 years before the present, harbor some of the best-preserved ancient DNA yet discovered. From 96 radiocarbon-aged bones, we report large numbers of mitochondrial haplotypes, some of which appear to be extinct, given the 380 living birds sampled. We demonstrate DNA sequence evolution through time and estimate the rate of evolution of the hypervariable region I using a Markov chain Monte Carlo integration and a least-squares regression analysis. Our calculated rates of evolution are approximately two to seven times higher than previous indirect phylogenetic estimates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lambert, D M -- Ritchie, P A -- Millar, C D -- Holland, B -- Drummond, A J -- Baroni, C -- New York, N.Y. -- Science. 2002 Mar 22;295(5563):2270-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular BioSciences, Massey University, Private Bag 11-222, Palmerston North, New Zealand. D.M.Lambert@massey.ac.nz〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11910113" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; Birds/*genetics ; Bone and Bones/metabolism ; Calibration ; Carbon Radioisotopes ; DNA, Mitochondrial/*genetics/isolation & purification ; Ecosystem ; *Evolution, Molecular ; Fossils ; Haplotypes/genetics ; Least-Squares Analysis ; Markov Chains ; Monte Carlo Method ; Phylogeny ; Polymerase Chain Reaction ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Impacts of soil faunal community composition on model grassland ecosystems (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-19
    Description: Human impacts, including global change, may alter the composition of soil faunal communities, but consequences for ecosystem functioning are poorly understood. We constructed model grassland systems in the Ecotron controlled environment facility and manipulated soil community composition through assemblages of different animal body sizes. Plant community composition, microbial and root biomass, decomposition rate, and mycorrhizal colonization were all markedly affected. However, two key ecosystem processes, aboveground net primary productivity and net ecosystem productivity, were surprisingly resistant to these changes. We hypothesize that positive and negative faunal-mediated effects in soil communities cancel each other out, causing no net ecosystem effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradford, M A -- Jones, T H -- Bardgett, R D -- Black, H I J -- Boag, B -- Bonkowski, M -- Cook, R -- Eggers, T -- Gange, A C -- Grayston, S J -- Kandeler, E -- McCaig, A E -- Newington, J E -- Prosser, J I -- Setala, H -- Staddon, P L -- Tordoff, G M -- Tscherko, D -- Lawton, J H -- New York, N.Y. -- Science. 2002 Oct 18;298(5593):615-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Environment Research Council Centre for Population Biology, Department of Biological Sciences, Imperial College at Silwood Park, Ascot, SL5 7PY, UK. m.a.bradford@ic.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12386334" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/growth & development ; Biomass ; Body Constitution ; Carbon/metabolism ; Ecological Systems, Closed ; *Ecosystem ; Environment ; Fungi/growth & development ; Oxygen Consumption ; Photosynthesis ; Plant Development ; Plant Roots/metabolism ; Poaceae/growth & development ; Population Density ; *Soil ; Soil Microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Environment. Frontier governance in Amazonia (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-01-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nepstad, D -- McGrath, D -- Alencar, A -- Barros, A C -- Carvalho, G -- Santilli, M -- Vera Diaz, M del C -- New York, N.Y. -- Science. 2002 Jan 25;295(5555):629-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Woods Hole Research Center (WHRC), Woods Hole, MA 02543-0296, USA. dnepstad@whrc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11809955" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Brazil ; *Conservation of Natural Resources/legislation & jurisprudence ; Economics ; *Ecosystem ; Fires ; Forestry ; Government ; Public Policy ; *Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Rainfall variability, carbon cycling, and plant species diversity in a mesic grassland (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-14
    Description: Ecosystem responses to increased variability in rainfall, a prediction of general circulation models, were assessed in native grassland by reducing storm frequency and increasing rainfall quantity per storm during a 4-year experiment. More extreme rainfall patterns, without concurrent changes in total rainfall quantity, increased temporal variability in soil moisture and plant species diversity. However, carbon cycling processes such as soil CO2 flux, CO2 uptake by the dominant grasses, and aboveground net primary productivity (ANPP) were reduced, and ANPP was more responsive to soil moisture variability than to mean soil water content. Our results show that projected increases in rainfall variability can rapidly alter key carbon cycling processes and plant community composition, independent of changes in total precipitation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knapp, Alan K -- Fay, Philip A -- Blair, John M -- Collins, Scott L -- Smith, Melinda D -- Carlisle, Jonathan D -- Harper, Christopher W -- Danner, Brett T -- Lett, Michelle S -- McCarron, James K -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2202-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, Kansas State University, Manhattan, KS 66506, USA. aknapp@ksu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481139" target="_blank"〉PubMed〈/a〉
    Keywords: Biomass ; Carbon/*metabolism ; Carbon Dioxide/metabolism ; *Ecosystem ; Kansas ; Photosynthesis ; *Plant Development ; Plants/metabolism ; Poaceae/*growth & development/metabolism ; *Rain ; Seasons ; Soil ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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